Grand Challenge IV

Understanding how genomes produce organisms

David RaibleBoard Member, Society for

Developmental BiologyProfessor, University of Washington

Sea urchin larvae

Grand Challenge IV

Understanding how genomes produce organismsGeneration of organismal diversity

Heliconius

Grand Challenge IV

Understanding how genomes produce organismsGeneration of organismal diversity

Geospiza

Grand Challenge IV

Understanding how genomes produce organismsEnvironmental influences on growth

Arabidopsis

The challenges in developmental biology

• Generation of cellular diversity• Generation of shape: morphogenesis• Growth, repair, regeneration

Drosophila

The challenges in developmental biology

• Generation of cellular diversity• Generation of shape: morphogenesis• Growth, repair, regeneration

Carollia

The challenges in developmental biology

• Generation of cellular diversity• Generation of shape: morphogenesis• Growth, repair, regeneration

Cnemidophorus

Progress at the interface

• Convergence of genetics and development – Defining components

• Integration of Cell Biology– Cell shape to tissue architecture

• Systems biology – the future?– Moving beyond the descriptive

Systematic analysis of development

• Gene regulatory networks

Systematic analysis of development

• In toto imaging

Kane and Karlstrom, 1995

Systematic analysis of development

• In toto imaging– xyzgt

http://www.embl.de/digitalembryo/

Moving forward• Instrumentation – ways to measure• Centralized databases (GCOB #11)

– Access, analyze, manipulate large data sets– Standardization

• New model organisms– Genomes– Genetics– Lab culture– Transgenics

• Quantitative training

Moving forward • Distribution of effort• Centralized resources• Distribution of data• Recognition