Grants & Contracts Awards Processed by Grants & Contracts

Join us as we congratulate the investigators listed below who have recently received a new or competitive renewal award:

*Total award amount reflects Direct Costs only for the duration of the project

January 2011

Principal Investigator: Kwangwook Ahn, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: T32 Training Grant with Cornell Total Award* Amount: $48,975 Award Date: 01/25/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institutes of Health

Principal Investigator: Boris C. Bastian, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: THE GNAQ Pathway as a Therapeutic Target in Uveal Melanoma Total Award* Amount: $1,143,965 Award Date: 01/06/11 Project Duration: 4 Years Awarding Agency: National Cancer Institute/ National Institutes of Health

Principal Investigator: Milan Chheda, MD Department/Program: Neurology Service Project Title: Characterization of GEFT as a Novel Glioblastoma Oncogene Total Award* Amount: $739,826 Award Date: 01/26/11 Project Duration: 5 Years Awarding Agency: National Institute of Neurological Disorders and Stroke/ National Institute on Drug Abuse

Principal Investigator: Gabriela Chiosis, PhD Department/Program: Medicine/Breast Cancer Medicine/Molecular Pharmacology & Chemistry Project Title: PU-H71 Cistrome to Identify New Cobminatorial Targets in SLBCL Total Award* Amount: $1,000 Award Date: 01/07/11 Project Duration: 1 Year Awarding Agency: Clinical and Translational Science Center/ Weill Medical College of Cornell University

Principal Investigator: Joseph Deasy, PhD Department/Program: Medical Physics Project Title: Normal Tissue Complication Modeling for Radiotherapy

Total Award* Amount: $39,430 Award Date: 01/26/11 Project Duration: 10 Months Awarding Agency: National Cancer Institute/ National Institutes of Health

Principal Investigator: James J. Hsieh, MD, PhD Department/Program: Medicine/Genitourinary Oncology Service Project Title: Molecular Mechanism of Checkpoint Control in Leukemia Total Award* Amount: $200,000 Award Date: 01/28/11 Project Duration: 1 Year Awarding Agency: American Cancer Society

Principal Investigator: Danwei Huangfu, PhD Department/Program: Developmental Biology Project Title: 2011 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 01/19/11 Project Duration: 3 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Mary Goll, PhD Department/Program: Developmental Biology Project Title: 2011 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 01/19/11 Project Duration: 3 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Jan Grimm, MD, PhD Department/Program: Radiology/Nuclear Medicine Service Project Title: 2011 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 01/19/11 Project Duration: 3 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Richard N. Kolesnick, MD Department/Program: Medicine/Endocrinology/Molecular Pharmacology & Chemistry Project Title: An Anti-Ceramide Antibody Mitigates the Radiation GI Syndrome Total Award* Amount: $74,994 Award Date: 01/14/11 Project Duration: 1 Year Awarding Agency: Duke University/ Radiation Countermeasures Center of Research Excellence

Principal Investigator: Katharina Kreymborg, PhD Department/Program: Immunology

Project Title: Functional Characterization of the New B7 Family Members B7-H3 and B7x and Determining Their Role in Tumor-Immunology Total Award* Amount: $141,000 Award Date: 01/13/11 Project Duration: 3 Years Awarding Agency: Cancer Research Institute

Principal Investigator: Alexander M. Lesokhin, MD Department/Program: Medicine/Lymphoma Service Project Title: Targeting Myeloid Derived Suppressor Cells in Immunotherapy for Melanoma Total Award* Amount: $675,000 Award Date: 01/01/11 Project Duration: 4 Years Awarding Agency: American Cancer Society

Principal Investigator: Minkui Luo, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Profile Substrates and Inhibitors of Protein Lysine Methyltransferase Total Award* Amount: $751,485 Award Date: 01/21/11 Project Duration: 4 Years Awarding Agency: National Cancer Institute/ National Institutes of Health

Principal Investigator: Michael H. Overholtzer, PhD Department/Program: Cell Biology Project Title: 2011 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 01/19/11 Project Duration: 3 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Marilyn D. Resh, PhD Department/Program: Cell Biology Project Title: Identification of Hedgehog Palmitoylation Inhibitors to Block Pancreatic Cancer Cell Growth Total Award* Amount: $160,000 Award Date: 01/11/11 Project Duration: 3 Year Awarding Agency: Cycle for Survival

Principal Investigator: Dirk Remus, PhD Department/Program: Molecular Biology Project Title: 2011 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 01/19/11 Project Duration: 3 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: David Scheinberg, MD, PhD Department/Program: Medicine/Leukemia/Molecular Pharmacology & Chemistry Project Title: Biology of Alpha Particle Immunotherapy Total Award* Amount: $728,279 Award Date: 01/06/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/ National Institutes of Health

Principal Investigator: Barbara Tanos-Lora, PhD Department/Program: Cell Biology Project Title: Mechanism Controlling Centrosome Duplication Total Award* Amount: $133,859 Award Date: 01/07/11 Project Duration: 3 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Megan van Overbeek, PhD Department/Program: Molecular Biology Project Title: The Role of Chromatin Architecture in Programmed Double-Strand Breaks Total Award* Amount: $105,964 Award Date: 01/13/11 Project Duration: 3 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Jedd D. Wolchok, MD, PhD Department/Program: Medicine/Melanoma and Sarcoma Service Project Title: Modulating Anti-Tumor Immunity with Dendritic Cells Total Award* Amount: $34,698 Award Date: 01/06/11 Project Duration: 1 Year Awarding Agency: New York University School of Medicine/ Melanoma Research Alliance Foundation

February 2011

Principal Investigator: Arnab Ghosh, MD, PhD Department/Program: Immunology Project Title: Neovascularuization in GVHD and Growth of Tumors in Recipients of allo-BMT Total Award* Amount: $90,000 Award Date: 10/25/10 Project Duration: 2 Years Awarding Agency: American Association for Cancer Research

Principal Investigator: Amy Lowery, PhD Department/Program: Psychiatry & Behavioral Sciences Project Title: A Survey of Older Pain Patients - Are They a Source of Diversion?

Total Award* Amount: $15,000 Award Date: 02/18/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institute on Aging

Principal Investigator: Li-Fan Lu, PhD Department/Program: Immunology Project Title: Function of microRNAs in Controlling Regulatory T Cell Biology Total Award* Amount: $87,266 Award Date: 02/17/11 Project Duration: 1 Year Awarding Agency: National Institute of Allergy and Infectious Diseases/ National Institutes of Health

Principal Investigator: Ariela Noy, MD Department/Program: Medicine/Lymphoma Service Project Title: AIDS Malignancy Clinical Trials Consortium Total Award* Amount: $114,117 Award Date: 02/02/11 Project Duration: 2 Years Awarding Agency: Emmes Corporation/National Institutes of Health

Principal Investigator: Li-Xuan Qin, PhD Department/Program: Epidemiology & Biostatistics Project Title: Statistical Methods for Normalizing Microarrays in Cancer Biomarker Studies Total Award* Amount: $989,790 Award Date: 02/18/11 Project Duration: 4 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Marilyn D. Resh, PhD Department/Program: Cell Biology Project Title: Hedgehog Palmitoylation as a Novel Target for Inhibiting Pancreatic Cancer Total Award* Amount: $239,250 Award Date: 02/14/11 Project Duration: 2 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Chris Sander, PhD Department/Program: Epidemiology & Biostatistics/Biostatistics/Computational Biology Project Title: Resource for Visualization and Analysis of Networks (RAVIN) Total Award* Amount: $100,000 Award Date: 02/18/11 Project Duration: 1 Year Awarding Agency: University of California, San Diego/National Institutes of Health

Principal Investigator: Todd Wenderski, PhD Department/Program: Molecular Pharmacology & Chemistry

Project Title: T32 Training Grant with Cornell Total Award* Amount: $45,185 Award Date: 02/01/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institutes of Health

Principal Investigator: Ann Zauber, PhD Department/Program: Epidemiology & Biostatistics Project Title: Phase II Clinical Trial of Celecoxib for Prevention of Sporadic Colorectal Adenomas Total Award* Amount: $165,985 Award Date: 02/01/11 Project Duration: 2 Years Awarding Agency: Brigham And Women's Hospital/National Cancer Institute

March 2011

Principal Investigator: Peter J. Allen, MD, FACS Department/Program: Surgery/Hepatopancreatobiliary Service Project Title: Detection of Pre-Invasive Pancreatic Cysts Using Protein and Glycan Biomarkers Total Award* Amount: $40,500 Award Date: 03/08/11 Project Duration: 1 Year Awarding Agency: Van Andel Institute/ National Cancer Institute

Principal Investigator: Vivek Arora, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Mechanisms of Prostate Cancer Resistance to Second Generation Anti-Androgens Total Award* Amount: $551,223 Award Date: 03/16/11 Project Duration: 5 Years Awarding Agency: Congressionally Directed Medical Research Programs/ DOE - Department of Energy

Principal Investigator: Robert Benezra, PhD Department/Program: Cancer Biology & Genetics Project Title: The Role of Endothelial Progenitor Cells in Tumor Growth and Metastasis Total Award* Amount: $1,733,746 Award Date: 03/18/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/ National Institutes of Health

Principal Investigator: Jay O. Boyle, MD Department/Program: Surgery/Head and Neck Service Project Title: Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer

Total Award* Amount: $5,000 Award Date: 03/09/11 Project Duration: 2 Years Awarding Agency: University of Minnesota/American Academy of Otolaryngology-Head and Neck Surgery Fdn

Principal Investigator: John Buglino, PhD Department/Program: Immunology Project Title: T32 Training Grant Total Award* Amount: $50,718 Award Date: 03/16/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institute of Allergy and Infectious Diseases

Principal Investigator: Emily H. Cheng, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Genetic Programs of Non-apoptotic Cell Death Total Award* Amount: $531,374.67 Award Date: 03/08/11 Project Duration: 3 Years Awarding Agency: American Cancer Society

Principal Investigator: Gabriela Chiosis, PhD Department/Program: Medicine/Breast Cancer Medicine/Molecular Pharmacology & Chemistry Project Title: Targeting the Heat Shock Response for the Therapy of DLBCL Total Award* Amount: $156,303 Award Date: 03/17/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institutes of Health

Principal Investigator: David J. Chung, MD, PhD Department/Program: Medicine/Bone Marrow Transplant Service Project Title: Evaluation of Immune Responses Mediated by Listeria-Stimulated Human Dendritic Cells: Implications for Cancer Vaccine Therapy Total Award* Amount: $300,000 Award Date: 03/17/11 Project Duration: 1 Year Awarding Agency: Congressionally Directed Medical Research Programs/ DOD - Department of Defense

Principal Investigator: David Cobrinik, MD, PhD Department/Program: Pediatrics/Cheung Research Project Title: Cellular Predisposition to Retinoblastoma Tumorigenesis Total Award* Amount: $1,037,500 Award Date: 03/01/11

Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Anna-Katerina Hadjantonakis, PhD Department/Program: Developmental Biology Project Title: Morphogenesis of the Paraxial Mesoderm in Mice Total Award* Amount: $1,303,913 Award Date: 03/29/11 Project Duration: 5 Years Awarding Agency: National Institute of Child Health and Human Development/National Institutes of Health

Principal Investigator: Anna-Katerina Hadjantonakis, PhD Department/Program: Developmental Biology Project Title: Pdgfra Signaling and the Stem Cells of the Early Mammalian Embryo Total Award* Amount: $274,864 Award Date: 03/15/11 Project Duration: 2 Years Awarding Agency: NYSTEM Program of New York State Department of Health

Principal Investigator: Yoon-Chi Han, PhD Department/Program: Cancer Biology & Genetics Project Title: OncmiR-1 in Lymphomagenesis and Hematopoiesis Total Award* Amount: $157,143 Award Date: 03/31/11 Project Duration: 3 Years Awarding Agency: Leukemia and Lymphoma Society

Principal Investigator: Jason T. Huse, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Personalizing PI3K/AKT Pathway Inhibitor Therapy in Malignant Glioma Total Award* Amount: $100,000 Award Date: 03/14/11 Project Duration: 2 Years Awarding Agency: American Association for Cancer Research/American Association for Cancer Research

Principal Investigator: Gabsang Lee, PhD Department/Program: Developmental Biology Project Title: Disease Modeling of Congenital Insensitivity to Pain and Anhidrosis (CIPA) disease using human iPSC and rescue of its phenotypes Total Award* Amount: $209,360 Award Date: 03/15/11 Project Duration: 2 Years Awarding Agency: NYSTEM Program of New York State Department of Health

Principal Investigator: Christopher D. Lima, PhD Department/Program: Structural Biology

Project Title: Targets in M. Tuberculosis: Stress Resistance and Repair Total Award* Amount: $70,000 Award Date: 03/10/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institute of Allergy and Infectious Diseases

Principal Investigator: Sara Olson, PhD Department/Program: Epidemiology & Biostatistics Project Title: Serum IgE and Risk of Pancreatic Cancer Total Award* Amount: $119,599 Award Date: 03/11/11 Project Duration: 2 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Ouathek Ouerfelli, PhD Department/Program: Organic Synthesis Core Facility (OSCF) Project Title: Biology of Lipoamide Dehydrogenase and 2-Hydroxy-3-Oxoadipate Synthase in Mtb Total Award* Amount: $70,000 Award Date: 03/16/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Institute of Allergy and Infectious Diseases

Principal Investigator: Michael H. Overholtzer, PhD Department/Program: Cell Biology Project Title: The Role of Entosis in Human Cancers Total Award* Amount: $1,037,500 Award Date: 03/25/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Mark E. Robson, MD Department/Program: Medicine/Breast Cancer Medicine Service/Clinical Genetics Service Project Title: Preclinical and Brief Exposure Early Clinical Evaluation of an Oral PARP inhibitor for Breast Cancer Prevention in BCRA Mutation Carriers Total Award* Amount: $5,938 Award Date: 03/28/11 Project Duration: 1 Year Awarding Agency: Dana Farber Cancer Institute/Susan G. Komen Breast Cancer Foundation

Principal Investigator: Jennifer Stockdill, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and Peptides Total Award* Amount: $166,666

Award Date: 03/14/11 Project Duration: 2 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Chambers Stuart, PhD Department/Program: Developmental Biology Project Title: Translational Control of Human Pluripotent Cell Maintenance and Neural Differentiation Total Award* Amount: $230,121 Award Date: 03/15/11 Project Duration: 2 Years Awarding Agency: NYSTEM Program of New York State Department of Health

Principal Investigator: Lorenz Studer, MD Department/Program: Neurosurgery/Departmental/Developmental Biology Project Title: Modeling Pathogenesis and Treatment of Familial Dysautonomia in Patient Specific Human Induced Pluripotent Stem Cells Total Award* Amount: $900,000 Award Date: 03/15/11 Project Duration: 3 Years Awarding Agency: NYSTEM Program of New York State Department of Health

Principal Investigator: Lorenz Studer, MD Department/Program: Neurosurgery/Departmental/Developmental Biology Project Title: Patient-specific human ESCs and IPSCs for Modeling Schwann Cell Differentiation and Charcot-Marie-Tooth Disease Total Award* Amount: $900,000 Award Date: 03/15/11 Project Duration: 3 Years Awarding Agency: NYSTEM Program of New York State Department of Health

Principal Investigator: Richard J. Wong, MD, FACS Department/Program: Surgery/Head and Neck Service Project Title: Mechanisms of Cancer Cell Chemotaxis in Perineural Invasion Total Award* Amount: $1,037,500 Award Date: 03/01/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

April 2011

Principal Investigator: Paula Bos, PhD Department/Program: Immunology Project Title: T Regulatory Cell Function in Breast Cancer Progression and Metastasis Total Award* Amount: $150,000 Award Date: 04/01/11

Project Duration: 3 Years Awarding Agency: American Cancer Society

Principal Investigator: Jamie Chaft, MD Department/Program: Thoracic Oncology Service Project Title: Molecular Determinants of Acquired Clinical Resistance to Criztinib in Non-Small Cell Lung Cancer Harboring a Translocation or Inversion Event of the ALK Gene Locus Total Award* Amount: $47,619 Award Date: 04/04/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Elizabeth Comen, MD Department/Program: Medicine Project Title: The Evaluation of the Cytotoxicity of Select Neutrophils in Inhibiting Metastatic Breast Total Award* Amount: $47,500 Award Date: 04/01/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Sandra D'Angelo, MD Department/Program: Medicine Project Title: Enhancing the Activity of Temozolomide for the Treatment of Stage Small Cell Lung Cancer by Addition of the PARP-1 Inhibitor Veliparib (ABT-888) Total Award* Amount: $47,620 Award Date: 04/01/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Hakim Djaballah, PhD Department/Program: High-Throughput Drug Screening Facility Project Title: Regulation of HD-ZIPIII Activity by the START Lipid-binding Domain Total Award* Amount: $26,316 Award Date: 04/27/11 Project Duration: 1 Year Awarding Agency: Cold Spring Harbor Laboratory/National Science Foundation

Principal Investigator: Ayca Gucalp, MD Department/Program: Breast Service Project Title: Targeting the Androgen Signaling Pathway for the Treatment of Advanced Breast Cancer Total Award* Amount: $47,612 Award Date: 04/05/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Alexia Iasonos, PhD Department/Program: Epidemiology & Biostatistics Project Title: Designs for Phase I Trials of Combinations of Agents Total Award* Amount: $10,619 Award Date: 04/27/11 Project Duration: 1 Year Awarding Agency: University of Virginia/National Cancer Institute

Principal Investigator: Irene Jarchum, PhD Department/Program: Immunology Project Title: Innate Immune Defense During Clostridium Difficile Colitis Total Award* Amount: $50,000 Award Date: 04/11/11 Project Duration: 1 Year Awarding Agency: Columbia University/Northeast Biodefense Center

Principal Investigator: Komal Jhaveri, MD Department/Program: Medicine Project Title: Increasing Efficiency of Drug Development with a Targeted Imaging Strategy: First-in-Human Phase I Trial of PU-H71, a Novel HSP90 Inhibitor with 124I-PU-H71 for the Treatment of Advanced Malignancies Total Award* Amount: $47,500 Award Date: 04/01/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Eric Lai, PhD Department/Program: Developmental Biology Project Title: Annotation of the Small RNA/microRNA Component Drosophila Genome Total Award* Amount: $1,431,645 Award Date: 04/01/11 Project Duration: 5 Years Awarding Agency: National Human Genome Research Institute/National Institutes of Health

Principal Investigator: Yueming Li, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Mechanism and Therapy of AB-42-Specific Gamma-Secretase Total Award* Amount: $2,245,037 Award Date: 04/22/11 Project Duration: 5 Years Awarding Agency: National Institute of Neurological Disorders and Stroke/National Institutes of Health

Principal Investigator: Elizabeth A. Morris, MD, FACR Department/Program: Radiology/Breast Imaging Service Project Title: Developing an Educational Program on Breast Imaging for the Chinese Radiology Society with International Cooperation

Total Award* Amount: $34,320 Award Date: 04/12/11 Project Duration: 2 Years Awarding Agency: Beijing Institute for Cancer Research/Radiological Society of North America

Principal Investigator: Patrick Morris, MBBS Department/Program: Breast Cancer Medicine Service Project Title: Association of Smoking, Lung Inflammation and Lung Metastases from Breast Cancer Total Award* Amount: $47,500 Award Date: 04/14/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Jamie Ostroff, PhD Department/Program: Psychiatry Project Title: Development of a Web-based, 3D Coping Skills Game to Increase Self-Efficacy for Maintaining Smoking Abstinence Total Award* Amount: $37,175 Award Date: 04/28/11 Project Duration: 1 Year Awarding Agency: Muzzy Lane Software/National Cancer Institute

Principal Investigator: Christopher Y. Park, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Functional Role of microRNAs in Hematopoietic Stem Cells in the Myelodysplastic Syndromes Total Award* Amount: $399,000 Award Date: 04/19/11 Project Duration: 3 Years Awarding Agency: Congressionally Directed Medical Research Programs

Principal Investigator: Paul Paik, MD Department/Program: Medicine Project Title: Characterization of the Molecular Heterogeneity of EGFR Mutant Lung Adenocarcinoma: Baseline and Post-Treatment Tumor Analysis Total Award* Amount: $47,620 Award Date: 04/01/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: William Polkinghorn, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Defining the Role of AR Signaling in Promoting Prostate Cancer Radioresistance Total Award* Amount: $47,500 Award Date: 04/27/11

Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: William P. Tew, MD Department/Program: Medicine/Gynecologic Medical Oncology Service Project Title: Geriatric Assessment and Intervention in Elderly Women with Ovarian Cancer Total Award* Amount: $138,888 Award Date: 04/29/11 Project Duration: 2 Years Awarding Agency: National Comprehensive Cancer Network Foundation

Principal Investigator: Emily S. Tonorezos, MD, MPH Department/Program: Medicine/General Internal Medicine Service Project Title: Diet and Insulin Resistance in Survivors of Childhood Leukemia Total Award* Amount: $300,000 Award Date: 04/01/11 Project Duration: 3 Years Awarding Agency: American Cancer Society

May 2011

Principal Investigator: Chong Chen, PhD Department/Program: Cancer Biology & Genetics Project Title: Identifying Druggable Targets in Acute Myeloid Leukemia Total Award* Amount: $165,000 Award Date: 05/11/11 Project Duration: 3 Years Awarding Agency: Leukemia and Lymphoma Society

Principal Investigator: Nai-Kong Cheung, MD, PhD Department/Program: Pediatrics Project Title: Engineering and Evaluation of Human L-Methionase for Cancer Therapy Total Award* Amount: $260,625 Award Date: 05/06/11 Project Duration: 3 Years Awarding Agency: University of Texas at Austin/ National Institutes of Health

Principal Investigator: Mark A. Dickson, MD Department/Program: Medicine/Melanoma and Sarcoma Service Project Title: A Phase II study of PD0332991 in Liposarcoma with CDK4 Amplification Total Award* Amount: $200,000 Award Date: 05/26/11 Project Duration: 3 Years Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Cherry L. Estilo, DMD Department/Program: Surgery/Dental Service Project Title: Intervention to Prevent Delayed Diagnosis of Oral Cancer

Total Award* Amount: $6,254.38 Award Date: 05/13/11 Project Duration: 4 Months Awarding Agency: Creighton University/National Institutes of Health

Principal Investigator: Alan L. Ho, MD, PhD Department/Program: Medicine/Head and Neck Oncology Service Project Title: A Randomized Phase II Study of Axitinib versus Placebo for Patients with Progressive, Recurrent and/or Metastatic Adenoid Cystic Carcinoma Total Award* Amount: $285,626 Award Date: 05/03/11 Project Duration: 2 Years Awarding Agency: National Comprehensive Cancer Network/ Pfizer, Inc.

Principal Investigator: Danwei Huangfu, PhD Department/Program: Developmental Biology Project Title: MSKCC Society Special Projects Committee Total Award* Amount: $125,000 Award Date: 05/12/11 Awarding Agency: MSKCC Society/ Memorial Sloan-Kettering Cancer Center

Principal Investigator: Isabel Lam Department/Program: Molecular Biology Project Title: Functional Characterization of Rec104 in Meiotic Recombination Total Award* Amount: $83,600 Award Date: 05/12/11 Project Duration: 2 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Philipp Niethammer, PhD Department/Program: Cell Biology Project Title: MSKCC Society Special Projects Committee Total Award* Amount: $125,000 Award Date: 05/12/11 Project Duration: 7 Months Awarding Agency: MSKCC Society/ Memorial Sloan-Kettering Cancer Center

Principal Investigator: Bhuvanesh Singh, MD, PhD, FACS Department/Program: Surgery/Head and Neck Service Project Title: Bacterial Colonization, Inflammation and its Role in Carcinogenesis Total Award* Amount: $10,169 Award Date: 05/25/11 Project Duration: 1 Year Awarding Agency: New York University/National Institute of Dental and Craniofacial Research

Principal Investigator: Robert J. Young, MD Department/Program: Radiology/Neuroradiology Service Project Title: Using Functional MRI and Diffusion Tensor Imaging of the Language Pathway to Optimize Brain Tumor Resection Total Award* Amount: $40,000 Award Date: 05/13/11 Project Duration: 1 Year Awarding Agency: Radiological Society of North America

Principal Investigator: Jamie Zampell, MD Department/Program: Surgery Project Title: Adaptive Immune Responses Regulate the Pathophysiology of Lymphedema Total Award* Amount: $99,698 Award Date: 05/27/11 Project Duration: 1 Year Awarding Agency: DOD - Department of Defense

June 2011

Principal Investigator: Claudia Ayash, MPH Department/Program: Psychiatry & Behavioral Sciences Project Title: AMBER- Arab American Breast Cancer Education and Referral Program Total Award* Amount: $63,557 Award Date: 06/14/11 Project Duration: 1 Year Awarding Agency: New York University School of Medicine/Susan G. Komen Breast Cancer Foundation

Principal Investigator: Robert Benezra, PhD Department/Program: Cancer Biology & Genetics Project Title: Novel Approaches to Target High Grade Ovarian Cancers Total Award* Amount: $698,000 Award Date: 07/22/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Patrick J. Boland, MD, FRCS(I), FRCS Department/Program: Surgery/Orthopaedic Service Project Title: Sacral Study Group and Sacrectomy Total Award* Amount: $20,000 Award Date: 06/23/11 Project Duration: 1 Year Awarding Agency: Orthopaedic Research and Education Foundation

Principal Investigator: Natalya Chernichenko, MD Department/Program: Surgery Project Title: The Role of Rho Family Proteins in Perineural Invasion by Cancer Cells Total Award* Amount: $36,500

Award Date: 07/28/11 Project Duration: 2 Years Awarding Agency: American Head and Neck Society

Principal Investigator: Nai-Kong Cheung, MD, PhD Department/Program: Pediatric Project Title: Phase I Study of Humanized 3F8 Monoclonal Antibody (Hu3F8) in Patients with High-Risk Neuroblastoma and GD2-Positive Tumors Total Award* Amount: $415,000 Award Date: 06/01/11 Project Duration: 2 Years Awarding Agency: National Institutes of Health

Principal Investigator: David J. Chung, MD, PhD Department/Program: Medicine/Bone Marrow Transplant Service Project Title: Evaluation of Immune Responses Mediated by Listeria-Stimulated Human Dendritic Cells: Implications for Cancer Vaccine Therapy Total Award* Amount: $300,000 Award Date: 06/06/11 Project Duration: 3 Years Awarding Agency: Congressionally Directed Medical Research Programs/DOD - Department of Defense

Principal Investigator: Joseph Deasy, PhD Department/Program: Medical Physics Project Title: Management of Breathing Effects in Radiotherapy Planning Total Award* Amount: $48,771 Award Date: 06/16/11 Project Duration: 1 Year Awarding Agency: Massachusetts General Hospital/National Cancer Institute

Principal Investigator: James A. Fagin, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Restoration of Radioiodine (RAI) Responsiveness in RAI-Refractory Thyroid Cancer. Total Award* Amount: $199,999 Award Date: 06/02/11 Project Duration: 2 Years Awarding Agency: MSKCC Society

Principal Investigator: Michael Glickman, MD Department/Program: Medicine/Infectious Disease/Immunology Project Title: An Integrated Host and Pathogen Genetic Strategy to Elucidate the Mechanism of Action of BCG in Therapy of Bladder Cancer Total Award* Amount: $393,806 Award Date: 07/27/11

Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Phillip Iaquinta, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Validation and Characterization of a Novel Prostate Cancer-Specific Genomic Deletion Associated with TMPRSS2-ERG Translocation Total Award* Amount: $105,646 Award Date: 06/17/11 Project Duration: 2 Years Awarding Agency: Congressionally Directed Medical Research Programs/DOD - Department of Defense

Principal Investigator: Teresa Kim, MD Department/Program: Surgery Project Title: Anti-CTLA-4 Enhances the Effects of Imatinib in Gastrointestinal Stromal Tumor Total Award* Amount: $107,776 Award Date: 07/26/11 Project Duration: 2 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Moritz F. Kircher, MD, PhD Department/Program: Radiology Project Title: Combined Preoperative MRI/Intraoperative Raman Imaging of Brain Total Award* Amount: $199,809 Award Date: 06/02/11 Project Duration: 2 Years Awarding Agency: MSKCC Society/Memorial Sloan-Kettering Cancer Center

Principal Investigator: David S. Klimstra, MD Department/Program: Pathology/Surgical Pathology Diagnostic Services, Gastrointestinal/Surgical Pathology Diagnostic Services, Thoracic Project Title: Dissecting Hedghog,TGF Beta and DMP Signaling During Pancreatic Tumorigenesis Total Award* Amount: $13,988 Award Date: 06/28/11 Project Duration: 1 Year Awarding Agency: University of Massachusetts/National Institutes of Health

Principal Investigator: Marc Ladanyi, MD Department/Program: Pathology/Diagnostic Molecular Pathology Project Title: Mutant EGF Receptor-Dependent Lung Cancer in Human Cell Lines and Transgenic Mice Total Award* Amount: $50,000 Award Date: 06/01/11

Project Duration: 1 Year Awarding Agency: Yale University/National Cancer Institute

Principal Investigator: Eirini Papapetrou, MD, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Genetic Correction of Human Beta-Thalassemic Induced Pluripotent Stem Cells Total Award* Amount: $166,666 Award Date: 06/24/11 Project Duration: 2 Years Awarding Agency: National Institute of Diabetes & Digestive & Kidney Diseases/National Institutes of Health

Principal Investigator: Christopher Y. Park, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: MSK Society Grant Application Total Award* Amount: $200,000 Award Date: 06/02/11 Project Duration: 2 Years Awarding Agency: MSKCC Society

Principal Investigator: Jae Park, MD Department/Program: Medicine Project Title: Consolidative Adoptive Immunotherapy of B-Cell Leukemia With Genetically Modified Autologous T Cells Total Award* Amount: $47,500 Award Date: 06/21/11 Project Duration: 1 Year Awarding Agency: Conquer Cancer Foundation of the American Society of Clinical Oncology

Principal Investigator: Vladimir Ponomarev, MD, PhD Department/Program: Radiology Project Title: Imaging T-cell Activation and Co-stimulation in Prostate Cancer Immunotherapy Total Award* Amount: $1,037,500 Award Date: 06/01/11 Project Duration: 5 Years Awarding Agency: National Institutes of Health

Principal Investigator: Chris Sander, PhD Department/Program: Epidemiology & Biostatistics/Biostatistics/Computational Biology Project Title: Transforming Genomics Data Visualization for Cancer Research Total Award* Amount: $144,000 Award Date: 06/01/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Joseph Sun, PhD Department/Program: Immunology

Project Title: Natural Killer Cell Responses Against Cancer and Infectious Disease Total Award* Amount: $200,000 Award Date: 06/23/11 Project Duration: 4 Years Awarding Agency: Cancer Research Institute

Principal Investigator: Craig B. Thompson, MD Department/Program: Cancer Biology & Genetics Project Title: Apoptosis Control by Bcl-2 Family Members Total Award* Amount: $379,404 Award Date: 06/08/11 Project Duration: 1 Year Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Craig B. Thompson, MD Department/Program: Cancer Biology & Genetics Project Title: Cancer Cell Survival During Factor Deprivation Total Award* Amount: $582,609 Award Date: 06/21/11 Project Duration: 3 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Marcel Van Den Brink, MD, PhD Department/Program: Medicine/Division of Hematologic Oncology/Immunology Project Title: Strategies to enhance immune reconstitution after bone marrow transplant Total Award* Amount: $1,680,937 Award Date: 06/10/11 Project Duration: 5 Years Awarding Agency: National Heart, Lung, and Blood Institute/National Institutes of Health

July 2011

Principal Investigator: Carol A. Aghajanian, MD Department/Program: Medicine/Gynecologic Medical Oncology Project Title: A Comprehensive Molecular Profiling and Novel Targeted Therapeutic Intervention for Low-Grade Serous and Serous Borderline Ovarian Cancer Total Award* Amount: $236,854 Award Date: 07/19/11 Project Duration: 3 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Hikmat A. Al-Ahmadie, MD Department/Program: Pathology/Surgical Pathology Diagnostic Services, Genitourinary Project Title: Genomic Characterization of Small Cell Carcinoma of the Bladder Using Whole Genome Sequencing and Molecular Inversion Probe (MIP) Arrays: a Biomarker Integrated Approach in a Rare but Aggressive Urothelial Neoplasm. Total Award* Amount: $97,902 Award Date: 07/19/11

Project Duration: 1 Year Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Zhirong Bao, PhD Department/Program: Developmental Biology Project Title: The Ubiquitin-Proteasome System in Metazoan Embryogenesis Total Award* Amount: $950,000 Award Date: 07/18/11 Project Duration: 5 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Michael F. Berger, PhD Department/Program: Pathology/Genetics Research Project Title: High-Throughput Profiling of Genomic Alterations in Clinical Tumor Specimens Total Award* Amount: $400,000 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Timothy Chan, MD, PhD Department/Program: Radiation Oncology Project Title: Elucidating the Function of the Widely Inactivated Phosphatase PTPRD in the Molecular Pathogenesis of Glioblastoma Total Award* Amount: $1,037,500 Award Date: 07/15/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Sarat Chandarlapaty, MD Department/Program: Medicine/Breast Cancer Medicine Service Project Title: Targeting AKT Inhibitor-Induced Feedback Signaling in Breast Cancer Total Award* Amount: $399,957 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Ping Chi, MD Department/Program: Medicine Project Title: Elucidating the Roles of ETV1 in the Pathogenesis of GIST Total Award* Amount: $785,135 Award Date: 07/01/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Liang Deng, MD, PhD Department/Program: Medicine/Dermatology Service Project Title: Host Defense Against Poxviruses and Viral Immune Evasion Total Award* Amount: $250,000 Award Date: 07/20/11 Project Duration: 1 Year Awarding Agency: National Institute of Allergy and Infectious Diseases/National Institutes of Health

Principal Investigator: Kinh Gian Do, MD, PhD Department/Program: Radiology Project Title: Development of Predictor and Prognostic Markers for Novel Therapies in Pancreatic Neuroendocrine Tumors Total Award* Amount: $148,848 Award Date: 07/19/11 Project Duration: 2 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Alan L. Ho, MD, PhD Department/Program: Medicine/Head and Neck Oncology Service Project Title: A Phase II Study of MK-2206 in Patients with Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma Total Award* Amount: $239,178 Award Date: 07/19/11 Project Duration: 3 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: Understanding Clonal Evolution and Heterogeneity of the Therapeutic Response by Lineage Tracing in Mouse Models of Glioma Total Award* Amount: $232,264 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: Utilizing Mouse Models of Residual and Recurrent Glioma to Uncover Mechanisms or Therapeutic Resistance Total Award* Amount: $240,000 Award Date: 07/19/11 Project Duration: 3 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Steven M. Horwitz, MD Department/Program: Medicine/Lymphoma Service Project Title: Novel Target Discovery Through Genomic and Functional Characterization of Mature T-cell Lymphomas Total Award* Amount: $240,000 Award Date: 07/19/11 Project Duration: 3 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Xuejun Jiang, PhD Department/Program: Cell Biology Project Title: Mechanism and Therapeutic Potential of PTEN Regulation upon Hypoxia Total Award* Amount: $400,000 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Johanna A. Joyce, PhD Department/Program: Cancer Biology & Genetics Project Title: Developing a Unique Mouse Model of Poorly Differentiated Pancreatic Neuroendocrine Tumors as a Preclinical Trial Platform Total Award* Amount: $240,000 Award Date: 07/19/11 Project Duration: 3 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Johanna A. Joyce, PhD Department/Program: Cancer Biology & Genetics Project Title: Evaluating CSF1R Inhibition as a Novel Target in Gliomagenesis Total Award* Amount: $240,000 Award Date: 07/19/11 Project Duration: 3 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Moritz F. Kircher, MD, PhD Department/Program: Radiology Project Title: Combined Pre- and Intraoperative Brain Tumor Imaging Using a Novel Dual-Modality Raman-MRI Nanoparticle Probe Total Award* Amount: $350,466 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Moritz F. Kircher, MD, PhD Department/Program: Radiology

Project Title: Raman Microscope for Label-free Tissue Characterization and High-Sensitivity Detection of Raman Contrast Agents Total Award* Amount: $150,000 Award Date: 07/18/11 Project Duration: 1 Year Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: David W. Kissane, MD Department/Program: Psychiatry and Behavioral Sciences Project Title: Communication Skills Intervention to Promote Transition into Survivorship Total Award* Amount: $2,187,134 Award Date: 07/05/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Robert Klein, PhD Department/Program: Cancer Biology & Genetics Project Title: Transcriptional Regulatory SNPs as a Mechanism for Prostate Cancer Risk Loci Total Award* Amount: $400,000 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Andrew C. Koff, PhD Department/Program: Molecular Biology Project Title: Exploring the Role of PD0332991 on the Treatment of Glioma Total Award* Amount: $150,480 Award Date: 07/19/11 Project Duration: 2 Years Awarding Agency: Cycle for Survival/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Steven M. Larson, MD Department/Program: Radiology/Nuclear Medicine/Molecular Pharmacology & Chemistry Project Title: The ICMIC Bridge Fund Total Award* Amount: $100,000 Award Date: 07/07/11 Awarding Agency: Philanthropic Funds

Principal Investigator: Ross Levine, MD Department/Program: Medicine/Human Oncology & Pathogenesis Program (HOPP) Project Title: Whole Genome Sequencing to Identify Germline and Somatic Disease Alleles Total Award* Amount: $69,444 Award Date: 07/07/11 Project Duration: 1 Year Awarding Agency: Brigham And Women's Hospital/ MPD Foundation

Principal Investigator: Jason S. Lewis, PhD Department/Program: Radiology/Radiochemistry Service Project Title: Development of 89Zr-5A10 for the Measurement of AR Signaling in Advanced Prostate Cancer Total Award* Amount: $400,000 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Paul Paik, MD Department/Program: Medicine Project Title: Squamous Cell Carcinoma of the Lung Mutation Analysis Program (SQ-MAP) Total Award* Amount: $181,630 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Christopher Y. Park, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: The Role of microRNAs in Stem Cells of the Aging Hematopoietic System Total Award* Amount: $91,094 Award Date: 07/06/11 Project Duration: 2 Years Awarding Agency: American Federation for Aging Research

Principal Investigator: John Petrini, PhD Department/Program: Molecular Biology Project Title: Rad50: Roles in Chromosome Stability and Prevention of Malignancy Total Award* Amount: $1,195,047 Award Date: 07/04/11 Project Duration: 4 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Simon N. Powell, MD, PhD, FRCP Department/Program: Radiation Oncology Project Title: Genomic Determinants of Radiosensitivity Total Award* Amount: $400,000 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Charles Sawyers, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP)

Project Title: Translational Research in Oncology Training Program Total Award* Amount: $944,892 Award Date: 07/11/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute

Principal Investigator: David Scheinberg, MD, PhD Department/Program: Medicine/Leukemia/Molecular Pharmacology & Chemistry Project Title: Smart Nano-Devices for Cancer therapy Total Award* Amount: $83,500 Award Date: 07/18/11 Awarding Agency: MSKCC Society

Principal Investigator: Ying Taur, MD, MPH Department/Program: Medicine/Infectious Diseases Service Project Title: Effects of the Intestinal Microbiota on Infections During Bone Marrow Transplant Total Award* Amount: $602,375 Award Date: 07/18/11 Project Duration: 5 Years Awarding Agency: National Institute of Allergy and Infectious Diseases/ National Institutes of Health

Principal Investigator: Marcel Van Den Brink, MD, PhD Department/Program: Medicine/Division of Hematologic Oncology/Immunology Project Title: Endothelial Precursor Cells in Allogeneic Bone Marrow Transplantation During Graft-Versus-Host Disease and Graft-Versus-Tumor Activity Total Award* Amount: $400,000 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Andrea Ventura, MD, PhD Department/Program: Cancer Biology & Genetics Project Title: Investigating the miR-34 Family of Tumor Suppressive miRNAs Total Award* Amount: $394,536 Award Date: 07/18/11 Project Duration: 2 Years Awarding Agency: Geoffrey Beene Cancer Research Center/Memorial Sloan-Kettering Cancer Center

Principal Investigator: Andrew J. Vickers, PhD Department/Program: Epidemiology & Biostatistics Project Title: Acupuncture Trialists' Collaboration: Meta-Analysis of Chronic Pain Trials Total Award* Amount: $917,500 Award Date: 07/18/11

Project Duration: 5 Years Awarding Agency: National Center for Complementary and Alternative Medicine

Principal Investigator: Jedd D. Wolchok, MD, PhD Department/Program: Medicine/Melanoma and Sarcoma Service Project Title: Summer Research Experiences for Medical Students Supervised by Faculty Mentors Total Award* Amount: $1,283,271 Award Date: 07/29/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Ji Zhang, PhD Department/Program: Cancer Biology & Genetics Project Title: Determining the Mechanism of p53 Resistance in a Mouse Model of B Cell Lymphoma Total Award* Amount: $52,381 Award Date: 07/01/11 Project Duration: 2 Years Awarding Agency: Leukemia and Lymphoma Society

August 2011

Principal Investigator: Luca Cartegni, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Activation of Natural RTK Inhibitors in Cancer Therapy Total Award* Amount: $360,000 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Sergio Giralt, MD Department/Program: Bone Marrow Transplant Service Project Title: MSKCC BMT CTN PROPOSAL Total Award* Amount: $616,500 Award Date: 08/08/11 Project Duration: 6 Years Awarding Agency: National Heart, Lung, and Blood Institute/National Institutes of Health

Principal Investigator: Alan Hall, PhD Department/Program: Cell Biology Project Title: Rho GTPases and Polarity Signaling Pathways in Morphogenesis and Migration Total Award* Amount: $1,524,997 Award Date: 08/15/11 Project Duration: 4 Years Awarding Agency: National Institute of General Medical Sciences/ National Institutes of Health

Principal Investigator: James J. Hsieh, MD, PhD Department/Program: Medicine/Genitourinary Oncology Service Project Title: Investigation of the ATRX-Daxx Chromatin-Remodeling Complex in Pancreatic Neuroendocrine Tumors Total Award* Amount: $264,772 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Eric Lai, PhD Department/Program: Developmental Biology Project Title: BEN Factors are Conserved CSL Co-Repressors in Notch-Mediated Neural Development Total Award* Amount: $1,207,639 Award Date: 08/26/11 Project Duration: 5 Years Awarding Agency: National Institute of Neurological Disorders and Stroke/ National Institutes of Health

Principal Investigator: Yueming Li, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Regulation and Function of Gamma-Secretase Total Award* Amount: $1,025,000 Award Date: 08/17/11 Project Duration: 11 Years Awarding Agency: National Institute on Aging/National Institutes of Health

Principal Investigator: Stephen D. Nimer, MD Department/Program: Medicine/Hematology Service/Molecular Pharmacology & Chemistry Project Title: Bromodomain Inhibition as Targeted Therapy in Acute Myeloid Leukemia Total Award* Amount: $333,333 Award Date: 08/15/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Kenneth Offit, MD Department/Program: Medicine/Clinical Genetics Service/Lymphoma Service Project Title: Genomewide Discovery of Novel Cancer Predisposing Mutations Total Award* Amount: $208,138 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Lorenz Studer, MD Department/Program: Neurosurgery/Departmental/Developmental Biology Project Title: Research Training Program in Stem Cell Biology Total Award* Amount: $1,725,000

Award Date: 08/05/11 Project Duration: 5 Years Awarding Agency: NYSTEM Program of New York State Department of Health

Principal Investigator: Craig B. Thompson, MD Project Leader: Ariela Noy, M.D. Department/Program: Cancer Biology & Genetics/Lymphoma Service Project Title: Cancer Center Support Grant: AIDS Malignancy Consortium Administrative Supplement Total Award* Amount: $140,294 Award Date: 08/30/11 Project Duration: 1 Year Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Michel Sadelain, MD, PhD Department/Program: Medicine/Hematology/Molecular Pharmacology & Chemistry Project Title: Regional Immune Interventions to Enhance Mesothelin Targeted Immunotherapy of Malignant Plueral Mesothelioma Total Award* Amount: $1,381,580 Award Date: 08/29/11 Project Duration: 3 Years Awarding Agency: Congressionally Directed Medical Research Programs

Principal Investigator: Charles Sawyers, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Genome Wide Profiling of Single Cells for Diagnosis and Monitoring in Prostate Cancer Total Award* Amount: $120,000 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Howard Scher, MD Department/Program: Medicine/Genitourinary Oncology Service Project Title: Genome Wide Profiling of Single Cells for Diagnosis and Monitoring in Prostate Cancer Total Award* Amount: $120,000 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Laura H. Tang, MD, PhD Department/Program: Pathology/Surgical Pathology Diagnostic Services, Gastrointestinal Project Title: Investigation of the ATRX-Daxx Chromatin-Remodeling Complex in Pancreatic Neuroendocrine Tumors Total Award* Amount: $89,990 Award Date: 08/02/11

Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Suzanne L. Wolden, MD, FACR Department/Program: Radiation Oncology/Brachytherapy Service/External Beam Radiotherapy Service, Manhattan Project Title: Cardiac Sparing Whole Lung IMRT in Children and Young Adults with Lung Metastases Total Award* Amount: $16,881 Award Date: 08/12/11 Project Duration: 2 Years Awarding Agency: Northwestern University/National Institutes of Health

Principal Investigator: Talia Zaider PhD Department/Program: Psychiatry Project Title: Theraputic Pathways to Improving End of Life Outcomes Among Families in Palliative Care Total Award* Amount: $24,250 Award Date: 08/01/11 Project Duration: 3 Years Awarding Agency: National Cancer Institute

Principal Investigator: Johannes Zakrzewski, MD Department/Program: Immunology Project Title: Strategies to Enhance Thymus-Independent T Cell Development in Cancer Patients Total Award* Amount: $605,045 Award Date: 08/10/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Pat Zanzonico, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: NanoSPECT/CT for Oncology Research Total Award* Amount: $907,340 Award Date: 08/09/11 Project Duration: 1 Year Awarding Agency: National Center for Research Resources/National Institutes of Health

September 2011

Principal Investigator: Omar Abdel-Wahab, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Role of ASXL1 Mutations in Myeloid Malignancies Total Award* Amount: $786,500 Award Date: 09/20/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Tim A. Ahles, PhD Department/Program: Psychiatry/Neuropsychiatry Project Title: The CCNY/MSKCC Partnership for Research Training and Outreach Total Award* Amount: $3,501,011 Award Date: 09/22/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Richard R. Barakat, MD, FACS Department/Program: Surgery/Gynecology Service Project Title: The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and Impact Total Award* Amount: $2,427,007 Award Date: 09/22/11 Project Duration: 5 Years Awarding Agency: National Institute of Nursing Research/National Institutes of Health

Principal Investigator: Ethan M. Basch, MD Department/Program: Medicine Project Title: Development of Pain Endpoint Models for Use in Prostate Cancer Clinical Trials and Drug Approval Total Award* Amount: $439,279 Award Date: 09/15/11 Project Duration: 3 Years Awarding Agency: Congressionally Directed Medical Research Programs/DOD - Department of Defense

Principal Investigator: Emily H. Cheng, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Apoptotic Network Integrated at the Mitochondrion Total Award* Amount: $184,300 Award Date: 09/08/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Ronald DeMatteo, MD, FACS Department/Program: Surgery/Colorectal Service/Hepatopancreatobiliary Service Project Title: Molecular Mechanisms in Gastrointestinal Stromal Tumor Total Award* Amount: $1,250,000 Award Date: 09/01/11 Project Duration: 13 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Katherine DuHamel, PhD Department/Program: Psychiatry & Behavioral Sciences Project Title: Improving CRC Screening for Diverse Hispanics in an Urban Primary Care Setting

Total Award* Amount: $2,329,498 Award Date: 09/16/11 Project Duration: 4 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Noor Gammoh, PhD Department/Program: Cell Biology Project Title: Molecular Basis of Autophagy and Its Role in Cancer Total Award* Amount: $164,526 Award Date: 09/13/11 Project Duration: 3 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Cole Haynes, MD Department/Program: Cell Biology Project Title: Maintenance of Mitochondrial Protein Folding as an Aging Effector Total Award* Amount: $1,025,000 Award Date: 09/13/11 Project Duration: 5 Years Awarding Agency: National Institute on Aging/National Institutes of Health

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: Tumor Microenvironment Network (TMEN) (U54) Total Award* Amount: $3,234,999 Award Date: 09/21/11 Project Duration: 5 Years Awarding Agency: National Institutes of Health

Principal Investigator: James J. Hsieh, MD, PhD Department/Program: Medicine/Genitourinary Oncology Service Project Title: Molecular Mechanisms of Impaired DAN Damage Response in Leukemia Pathogenesis Total Award* Amount: $1,033,904 Award Date: 09/12/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Joanne Kelvin, RN, MSN, AOCN Department/Program: Fertility Preservation and Parenthood After Cancer Treatment Project Title: Fertility Reproduction & Cancer Training Institute for Oncology Nursing (FRACTION) Total Award* Amount: $7,666 Award Date: 09/29/11 Project Duration: 4 Years Awarding Agency: H. Lee Moffitt Cancer Center & Research Institute/National Institutes of Health

Principal Investigator: Steven M. Larson, MD Department/Program: Radiology/Nuclear Medicine/Molecular Pharmacology & Chemistry Project Title: 124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer Total Award* Amount: $415,000 Award Date: 09/26/11 Project Duration: 2 Years Awarding Agency: National Institutes of Health

Principal Investigator: Steven M. Larson, MD Department/Program: Radiology/Nuclear Medicine/Molecular Pharmacology & Chemistry Project Title: MSKCC Center for Molecular Imaging in Cancer Total Award* Amount: $4,454,847 Award Date: 09/16/11 Project Duration: 16 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Scott Lowe, PhD Department/Program: Cancer Biology & Genetics Program Project Title: Ras Induced Senescence and Tumor Suppression Total Award* Amount: $585,228 Award Date: 09/09/11 Project Duration: 3 Years Awarding Agency: National Institute on Aging/National Institutes of Health

Principal Investigator: Kenneth Offit, MD Department/Program: Medicine/Clinical Genetics Service/Lymphoma Service Project Title: Genomewide Discovery of Novel Cancer Predisposing Mutations Total Award* Amount: $208,138 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Richard O’Reilly, MD Department/Program: Pediatrics/Departmental/Immunology Project Title: EBV Specific T-cells from 3rd Party Donors for Treatment of EBV-Associated Malignancies Total Award* Amount: $415,000 Award Date: 09/19/11 Project Duration: 2 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Chris Sander, PhD Department/Program: Epidemiology & Biostatistics/Biostatistics/Computational Biology Project Title: Pathway Commons: Research Resource for Biological Pathways Total Award* Amount: $2,422,831 Award Date: 09/23/11

Project Duration: 4 Years Awarding Agency: National Human Genome Research Institute/National Institutes of Health

Principal Investigator: Howard Scher, MD Department/Program: Medicine/Genitourinary Oncology Service Project Title: SPORE in Prostate Cancer Total Award* Amount: $5,427,347 Award Date: 09/01/11 Project Duration: 15 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Michel Sadelain, MD, PhD Department/Program: Medicine/Hematology/Molecular Pharmacology & Chemistry Project Title: Regional Immune Interventions to Enhance Mesothelin Targeted Immunotherapy of Malignant Plueral Mesothelioma Total Award* Amount: $1,381,580 Award Date: 08/29/11 Project Duration: 3 Years Awarding Agency: Congressionally Directed Medical Research Programs

Principal Investigator: Charles Sawyers, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Genome Wide Profiling of Single Cells for Diagnosis and Monitoring in Prostate Cancer Total Award* Amount: $120,000 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Howard Scher, MD Department/Program: Medicine/Genitourinary Oncology Service Project Title: Genome Wide Profiling of Single Cells for Diagnosis and Monitoring in Prostate Cancer Total Award* Amount: $120,000 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Laura H. Tang, MD, PhD Department/Program: Pathology/Surgical Pathology Diagnostic Services, Gastrointestinal Project Title: Investigation of the ATRX-Daxx Chromatin-Remodeling Complex in Pancreatic Neuroendocrine Tumors Total Award* Amount: $89,990 Award Date: 08/02/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Craig B. Thompson, MD Project Leader: Antonio Omuro, MD Department/Program: Neurology Project Title: Cancer Center Support Grant, Clinical Investigator Team Leadership Award Total Award* Amount: $50,000 Award Date: 09/01/11 Project Duration: 9 Months Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Craig B. Thompson, MD Project Leader: Colette Houston Department/Program: Office of Clinical Research Project Title: Cancer Center Support Grant, Clinical Trials Reporting Program Supplement Total Award* Amount: $75,000 Award Date: 09/08/11 Project Duration: 9 Months Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Elizabeth Wasmuth Department/Program: Structural Biology Project Title: Structural and Biochemical Characterization of the S. cerevisiae RNA Exosome Total Award* Amount: $167,200 Award Date: 08/11/11 Project Duration: 4 Years Awarding Agency: National Institute of General Medical Sciences/National Institutes of Health

Principal Investigator: Joao Xavier, PhD Department/Program: Computational Biology Project Title: Engineering Microbial Social Interactions: Towards New Anti-Biofilm Therapies Total Award* Amount: $1,500,000 Award Date: 09/23/11 Project Duration: 5 Years Awarding Agency: National Institutes of Health - Office of the Director/National Institutes of Health

Principal Investigator: Ann Zauber, PhD Department/Program: Epidemiology & Biostatistics Project Title: Comparative Effectiveness of Virtual and Optical Colonoscopy for CRC Surveillance Total Award* Amount: $9,284 Award Date: 09/16/11 Project Duration: 5 Years Awarding Agency: Fox Chase Cancer Center/National Institutes of Health

September 2011

Principal Investigator: Omar Abdel-Wahab, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Role of ASXL1 Mutations in Myeloid Malignancies Total Award* Amount: $786,500 Award Date: 09/20/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Tim A. Ahles, PhD Department/Program: Psychiatry/Neuropsychiatry Project Title: The CCNY/MSKCC Partnership for Research Training and Outreach Total Award* Amount: $3,501,011 Award Date: 09/22/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Richard R. Barakat, MD, FACS Department/Program: Surgery/Gynecology Service Project Title: The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and Impact Total Award* Amount: $2,427,007 Award Date: 09/22/11 Project Duration: 5 Years Awarding Agency: National Institute of Nursing Research/National Institutes of Health

Principal Investigator: Ethan M. Basch, MD Department/Program: Medicine Project Title: Development of Pain Endpoint Models for Use in Prostate Cancer Clinical Trials and Drug Approval Total Award* Amount: $439,279 Award Date: 09/15/11 Project Duration: 3 Years Awarding Agency: Congressionally Directed Medical Research Programs/DOD - Department of Defense

Principal Investigator: Emily H. Cheng, MD, PhD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Apoptotic Network Integrated at the Mitochondrion Total Award* Amount: $184,300 Award Date: 09/08/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Ronald DeMatteo, MD, FACS Department/Program: Surgery/Colorectal Service/Hepatopancreatobiliary Service Project Title: Molecular Mechanisms in Gastrointestinal Stromal Tumor Total Award* Amount: $1,250,000

Award Date: 09/01/11 Project Duration: 13 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Katherine DuHamel, PhD Department/Program: Psychiatry & Behavioral Sciences Project Title: Improving CRC Screening for Diverse Hispanics in an Urban Primary Care Setting Total Award* Amount: $2,329,498 Award Date: 09/16/11 Project Duration: 4 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Noor Gammoh, PhD Department/Program: Cell Biology Project Title: Molecular Basis of Autophagy and Its Role in Cancer Total Award* Amount: $164,526 Award Date: 09/13/11 Project Duration: 3 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Cole Haynes, MD Department/Program: Cell Biology Project Title: Maintenance of Mitochondrial Protein Folding as an Aging Effector Total Award* Amount: $1,025,000 Award Date: 09/13/11 Project Duration: 5 Years Awarding Agency: National Institute on Aging/National Institutes of Health

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: Tumor Microenvironment Network (TMEN) (U54) Total Award* Amount: $3,234,999 Award Date: 09/21/11 Project Duration: 5 Years Awarding Agency: National Institutes of Health

Principal Investigator: James J. Hsieh, MD, PhD Department/Program: Medicine/Genitourinary Oncology Service Project Title: Molecular Mechanisms of Impaired DAN Damage Response in Leukemia Pathogenesis Total Award* Amount: $1,033,904 Award Date: 09/12/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Joanne Kelvin, RN, MSN, AOCN Department/Program: Fertility Preservation and Parenthood After Cancer Treatment

Project Title: Fertility Reproduction & Cancer Training Institute for Oncology Nursing (FRACTION) Total Award* Amount: $7,666 Award Date: 09/29/11 Project Duration: 4 Years Awarding Agency: H. Lee Moffitt Cancer Center & Research Institute/National Institutes of Health

Principal Investigator: Steven M. Larson, MD Department/Program: Radiology/Nuclear Medicine/Molecular Pharmacology & Chemistry Project Title: 124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer Total Award* Amount: $415,000 Award Date: 09/26/11 Project Duration: 2 Years Awarding Agency: National Institutes of Health

Principal Investigator: Steven M. Larson, MD Department/Program: Radiology/Nuclear Medicine/Molecular Pharmacology & Chemistry Project Title: MSKCC Center for Molecular Imaging in Cancer Total Award* Amount: $4,454,847 Award Date: 09/16/11 Project Duration: 16 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Jason S. Lewis, PhD Department/Program: Radiology/Radiochemistry Service Project Title: Integrated Manhattan Project for Excellence in Radiochemistry (IMPER) Total Award* Amount: $568,371 Award Date: 09/22/11 Project Duration: 1 Year Awarding Agency: DOE - Department of Energy

Principal Investigator: Scott Lowe, PhD Department/Program: Cancer Biology & Genetics Program Project Title: Ras Induced Senescence and Tumor Suppression Total Award* Amount: $585,228 Award Date: 09/09/11 Project Duration: 3 Years Awarding Agency: National Institute on Aging/National Institutes of Health

Principal Investigator: Richard O’Reilly, MD Department/Program: Pediatrics/Departmental/Immunology Project Title: EBV Specific T-cells from 3rd Party Donors for Treatment of EBV-Associated Malignancies Total Award* Amount: $415,000 Award Date: 09/19/11

Project Duration: 2 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Chris Sander, PhD Department/Program: Epidemiology & Biostatistics/Biostatistics/Computational Biology Project Title: Pathway Commons: Research Resource for Biological Pathways Total Award* Amount: $2,422,831 Award Date: 09/23/11 Project Duration: 4 Years Awarding Agency: National Human Genome Research Institute/National Institutes of Health

Principal Investigator: Charles Sawyers, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Discovery of Prostate Cancer Tumor Suppressors and Treatment Biomarkers Through In Vivo RNA Interference Screens Total Award* Amount: $450,000 Award Date: 09/01/11 Project Duration: 2 Years Awarding Agency: Starr Cancer Consortium

Principal Investigator: Howard Scher, MD Department/Program: Medicine/Genitourinary Oncology Service Project Title: SPORE in Prostate Cancer Total Award* Amount: $5,427,347 Award Date: 09/01/11 Project Duration: 15 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Craig B. Thompson, MD Project Leader: Antonio Omuro, MD Department/Program: Neurology Project Title: Cancer Center Support Grant, Clinical Investigator Team Leadership Award Total Award* Amount: $50,000 Award Date: 09/01/11 Project Duration: 9 Months Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Craig B. Thompson, MD Project Leader: Colette Houston Department/Program: Office of Clinical Research Project Title: Cancer Center Support Grant, Clinical Trials Reporting Program Supplement Total Award* Amount: $75,000 Award Date: 09/08/11 Project Duration: 9 Months Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Joao Xavier, PhD Department/Program: Computational Biology

Project Title: Engineering Microbial Social Interactions: Towards New Anti-Biofilm Therapies Total Award* Amount: $1,500,000 Award Date: 09/23/11 Project Duration: 5 Years Awarding Agency: National Institutes of Health - Office of the Director/National Institutes of Health

Principal Investigator: Ann Zauber, PhD Department/Program: Epidemiology & Biostatistics Project Title: Comparative Effectiveness of Virtual and Optical Colonoscopy for CRC Surveillance Total Award* Amount: $9,284 Award Date: 09/16/11 Project Duration: 5 Years Awarding Agency: Fox Chase Cancer Center/National Institutes of Health

October 2011

Principal Investigator: Ming Li, PhD Department/Program: Immunology Project Title: Transforming Growth Factor-beta1 Control of Tumor Immune Evasion Total Award* Amount: $600,000 Award Date: 10/13/11 Project Duration: 3 Years Awarding Agency: American Cancer Society

Principal Investigator: Scott Lowe, PhD Department/Program: Cancer Biology & Genetics Program Project Title: Mechanisims of Treatment Responsiveness and Resistance in Myeloid Malignancies/LLS SCOR Total Award* Amount: $2,581,029 Award Date: 10/14/11 Project Duration: 2 Years Awarding Agency: Leukemia and Lymphoma Society

Principal Investigator: Mary S. McCabe, RN, MA Department/Program: Cancer Survivorship Initiative Project Title: Preparing Professional Nurses for Cancer Survivorship Care Total Award* Amount: $46,296 Award Date: 10/28/11 Project Duration: 1 Year Awarding Agency: City of Hope National Medical Center/National Cancer Institute

Principal Investigator: Xiaolan Zhao, PhD Department/Program: Molecular Biology Project Title: Studying the Roles of Sumoylation in the Maintenance of Genomic Stability Total Award* Amount: $600,000 Award Date: 10/13/11

Project Duration: 3 Years Awarding Agency: American Cancer Society

November 2011

Principal Investigator: Yu Chen, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: 2012 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 11/30/11 Project Duration: 4 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Peter Cook, PhD Department/Program: Cancer Biology & Genetics Project Title: Molecular Mechanisms Controlling Cell Senescence Within the Adult Brain Total Award* Amount: $102,000 Award Date: 11/11/11 Project Duration: 1 Year Awarding Agency: American Cancer Society

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: DFCI (U54-CA143798) COI Total Award* Amount: $39,092 Award Date: 11/15/11 Project Duration: 1 Year Awarding Agency: Dana Farber Cancer Institute/National Cancer Institute

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: DFCI (U54-CA143798) Core A Total Award* Amount: $97,799 Award Date: 11/15/11 Project Duration: 1 Year Awarding Agency: Dana Farber Cancer Institute/National Cancer Institute

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: DFCI (U54-CA143798) Project 2 "The Cell-of-Origin of Human Cancers" Total Award* Amount: $82,565 Award Date: 11/15/11 Project Duration: 1 Year Awarding Agency: Dana Farber Cancer Institute/National Cancer Institute:

Principal Investigator: Eric Holland, MD Department/Program: Neurosurgery/Departmental/Cancer Biology and Genetics Project Title: DFCI (U54-CA143798) Project 3 "Novel Tools to Predict & Prevent the

Emergence of Resistance to Targeted Drugs & Radiation Therapy" Total Award* Amount: $82,565 Award Date: 11/15/11 Project Duration: 1 Year Awarding Agency: Dana Farber Cancer Institute/National Cancer Institute

Principal Investigator: Michael Kharas, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: The Role of the Musashi Family in Hematopoiesis Total Award* Amount: $388,900 Award Date: 11/18/11 Project Duration: 5 Years Awarding Agency: National Institute of Diabetes & Digestive & Kidney Diseases/National Institutes of Health

Principal Investigator: Michael Kharas, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: 2012 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 11/30/11 Project Duration: 4 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Kitai Kim, PhD Department/Program: Cancer Biology & Genetics Project Title: 2012 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 11/30/11 Project Duration: 4 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Ross Levine, MD Department/Program: Medicine/Human Oncology & Pathogenesis Program (HOPP) Project Title: Clinical and Translational Science Center Total Award* Amount: $49,160 Award Date: 11/18/11 Project Duration: 1 Year Awarding Agency: Clinical and Translational Science Center/National Center for Research Resources

Principal Investigator: Philipp Niethammer, PhD Department/Program: Cell Biology Project Title: 2012 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 11/30/11 Project Duration: 4 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Sara Olson, PhD Department/Program: Epidemiology & Biostatistics Project Title: Validation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci Total Award* Amount: $42,623 Award Date: 11/04/11 Project Duration: 4 Years Awarding Agency: Johns Hopkins University/National Institutes of Health

Principal Investigator: Alexandros Pertsinidis, PhD Department/Program: Structural Biology Project Title: 2012 Louis V. Gerstner Young Investigators Fund Award Total Award* Amount: $225,000 Award Date: 11/30/11 Project Duration: 4 Years Awarding Agency: Louis V. Gerstner Young Investigators Fund

Principal Investigator: Chris Sander, PhD Department/Program: Epidemiology & Biostatistics/Biostatistics/Computational Biology Project Title: DFCI (U54-CA143798) Project 1 "Developing a Mathematical Framework to Uncover the Sequence of Genetic Events During Tumor Development" Total Award* Amount: $269,610 Award Date: 11/15/11 Project Duration: 1 Year Awarding Agency: Dana Farber Cancer Institute/National Cancer Institute

December 2011

Principal Investigator: Prasad S. Adusumilli, MD Department/Program: Surgery/Thoracic Service Project Title: A Phase I Trial of Malignant Pleural Mesothelioma Treated with Autologous T Cells Genetically Targeted to the Cancer-Cell Surface Antigen Mesothelin Total Award* Amount: $135,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Colin Begg, PhD Department/Program: Epidemiology & Biostatistics/Departmental/Molecular Pharmacology & Chemistry Project Title: Biostatistics Core Total Award* Amount: $125,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Michelle S. Bradbury, MD, PhD Department/Program: Radiology/Neuroradiology Service Project Title: Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in a PDGFB-Driven

Murine High Grade Glioma Model Total Award* Amount: $140,000. Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Luca Cartegni, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Induction of natural EGFR inhibitors Total Award* Amount: $170,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Richard D. Carvajal, MD Department/Program: Medicine/Melanoma & Sarcoma Service Project Title: Experimental Therapeutics Unit of the Laurence S. Rockefeller Outpatient Pavilion Total Award* Amount: $50,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Paul B. Chapman, MD Department/Program: Medicine/Melanoma and Sarcoma Service Project Title: Clinical Grade Production Facility Total Award* Amount: $50,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Anne Chauveau, PhD Department/Program: Immunology Project Title: Role of DGK Alpha in Cytoskeleton Remodeling and T Cell Effector Functions Total Award* Amount: $164,500 Award Date: 12/15/11 Project Duration: 2 Years Awarding Agency: Cancer Research Institute

Principal Investigator: Nai-Kong Cheung, MD, PhD Department/Program: Pediatrics Project Title: Multistep Targeting of GD2 Using DOTA Hook Total Award* Amount: $180,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Daniel C. Danila, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Dasatinib-Sensitive Signature in Circulating Tumor Cells from Patients with Metastatic Prostate Cancer: Development of Predictive Biomarkers for Targeted Treatment Total Award* Amount: $180,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Hakim Djaballah, PhD Department/Program: High-Throughput Drug Screening Facility Project Title: HTS Core Facility Total Award* Amount: $110,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: James A. Fagin, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Molecular Pathophysiology of Thyroid Cell Growth Total Award* Amount: $856,425 Award Date: 12/16/11 Project Duration: 5 Years Awarding Agency: National Cancer Institute/National Institutes of Health

Principal Investigator: Yuman Fong, MD Department/Program: Hepatic Oncology Project Title: Preclinical Assessment of a hNIS Expressing Oncolytic Vaccinia Virus for Treatment of Pancreatic Cancer Total Award* Amount: $140,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Jenna Goldberg, MD Department/Program: Bone Marrow Transplant Service Project Title: Improving Outcomes Assessment in Chronic GvHD Total Award* Amount: $26,787 Award Date: 12/12/11 Project Duration: 6 Years Awarding Agency: Fred Hutchinson Cancer Research Center/National Cancer Institute

Principal Investigator: Julien Henri, PhD Department/Program: Structural Biology Project Title: RNA Processing and Degradation: Structural and Functional Characterization of TRAMP Complexes Total Award* Amount: $39,300.20

Award Date: 12/06/11 Project Duration: 1 Year Awarding Agency: European Molecular Biology Organization

Principal Investigator: Xuejun Jiang, PhD Department/Program: Cell Biology Project Title: Identification of Chemical Inhibitors of the ULK1 Kinase Complex Total Award* Amount: $180,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Joseph G. Jurcic, MD Department/Program: Medicine/Hematology Service/Leukemia Service Project Title: Toward the Cure of Adult Acute Lymphocytic Leukemia: A Personalized Genetic and Epigenetic, Chemo-Immunotherapeutic Approach Total Award* Amount: $1,053,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Michael Kharas, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: The Role of Musashi-2 in Hematopoiesis and Leukemia Total Award* Amount: $137,776 Award Date: 12/06/11 Project Duration: 2 Years Awarding Agency: American Society of Hematology

Principal Investigator: David W. Kissane, MD Department/Program: Psychiatry and Behavioral Sciences Project Title: Intimacy Enhancing Couples' Intervention for Localized Prostate Cancer Total Award* Amount: $194,460 Award Date: 12/01/11 Project Duration: 1 Year Awarding Agency: University of Medicine & Dentistry of New Jersey/National Cancer Institute

Principal Investigator: Marc Ladanyi, MD Department/Program: Pathology/Diagnostic Molecular Pathology Project Title: Pre-clinical Development of a Novel Class of Proteasome Inhibitors Total Award* Amount: $140,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Eric Lai, PhD Department/Program: Developmental Biology

Project Title: A Data Analysis Center for Integration of Fly and Worm modENCODE datasets Total Award* Amount: $40,252 Award Date: 12/29/11 Project Duration: 1 Year Awarding Agency: Massachusetts Institute of Technology/National Human Genome Research Institute

Principal Investigator: Jason S. Lewis, PhD Department/Program: Radiology/Radiochemistry Service Project Title: Radioimmunotherapy Research and Radiopharmacy Laboratory Total Award* Amount: $80,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Christopher D. Lima, PhD Department/Program: Structural Biology Project Title: Structural and Functional Studies of Eukaryotic Exosomes Total Award* Amount: $975,000 Award Date: 12/01/11 Project Duration: 7 Years Awarding Agency: National Institute of General Medical Sciences/ National Institutes of Health

Principal Investigator: Yueming Li, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Preclinical Studies of Sulfonamide Y-Secretase Inhibitors for Cancer Therapy Total Award* Amount: $160,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Scott Lowe, PhD Department/Program: Cancer Biology & Genetics Program Project Title: Roles and Regulation of p53 - Core C Total Award* Amount: $44,516 Award Date: 12/15/11 Project Duration: 5 Years Awarding Agency: Columbia University/ National Cancer Institute

Principal Investigator: Scott Lowe, PhD Department/Program: Cancer Biology & Genetics Program Project Title: Roles and Regulation of p53 - Project 3 Total Award* Amount: $192,275 Award Date: 12/15/11 Project Duration: 5 Years Awarding Agency: Columbia University/ National Cancer Institute

Principal Investigator: Minkui Luo, PhD Department/Program: Molecular Pharmacology & Chemistry Project Title: Develop Protein Methyltransferase Inhibitors as Anti-Cancer Drugs Total Award* Amount: $180,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Ingo K. Mellinghoff, MD Department/Program: Neurology/Neurology Service Project Title: Optimizing EGFR Blockade in Human Glioblastoma Total Award* Amount: $160,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Malcolm Moore, DPhil Department/Program: Medicine/Division of Hematologic Oncology/Cell Biology Project Title: Overlapping Airway Basal Cell Transcriptome Reprogramming in COPD and Lung Cancer Total Award* Amount: $200,000 Award Date: 12/19/11 Project Duration: 1 Year Awarding Agency: Weill Medical College of Cornell University/National Heart, Lung, and Blood Institute

Principal Investigator: Marilyn D. Resh, PhD Department/Program: Cell Biology Project Title: Preclinical Testing of Hedgehog Inhibitors in Pancreatic Cancer Total Award* Amount: $180,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Naiyer A. Rizvi, MD Department/Program: Medicine/Thoracic Oncology Service Project Title: Iso-Fludelone, a Novel Epothilone: First in Human Phase I Trial Total Award* Amount: $175,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Neal Rosen, MD, PhD Department/Program: Medicine/Breast Cancer Medicine/Molecular Pharmacology & Chemistry Project Title: Changing the Natural History of Metastatic Melanoma with Multimodality Therapy

Total Award* Amount: $875,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Charles Sawyers, MD Department/Program: Human Oncology & Pathogenesis Program (HOPP) Project Title: Towards a Cure for Prostate Cancer Total Award* Amount: $680,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: David R. Spriggs, MD Department/Program: Medicine/Gynecologic Medical Oncology Service Project Title: Curing Ovarian Cancer Through Early Detection and Personalized Treatment Total Award* Amount: $665,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Jedd D. Wolchok, MD, PhD Department/Program: Medicine/Melanoma and Sarcoma Service Project Title: Radioimmunotherapy Research and Radiopharmacy Laboratory Total Award* Amount: $75,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center

Principal Investigator: Nian Wu, PhD Department/Program: Shared Core Facilities Project Title: Analytical Pharmacology Core Facility Total Award* Amount: $100,000 Award Date: 12/21/11 Project Duration: 1 Year Awarding Agency: Experimental Therapeutics Center