Haplotype Diversity in Immune Related Genes Between Different Geographical Regions and

Populations

Haplotype frequencies, by color, for each of the 52 geographically distinct populations in the Human Diversity Panel N=1059 (Cann et al. 2002). Haplotype diversity is greater in Africa than other regions where only a few haplotypes are shared among all.

CMSC 734 Brian Staats 1/31/07

Cann, H et al; A Human Genome Diversity Cell Line Panel ; Science, Vol 296, Issue 5566, 261-262 , 12 April 2002

Haplotype Frequency Between Different Geographical Distinct Populations

Representative populations illustrating the haplotype frequency changes arguably occurring in a directional flow.

CMSC 734 Brian Staats 1/31/07

Haplotype Diversity Mapped to Geographical Origins

Geographically mapped haplotype distributions help provide further support for current theories of population migration “out of Africa” and the “ice bridge” into the Americas.

CMSC 734 Brian Staats 1/31/07

Nothing in biology makes sense…

Theodosius Dobzhansky

”“… except in the light of evolution.