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Pathway for the synthesis of hemoglobin molecule, simplified
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SYNTHETIC PATHWAY OF HAEMOGLOBIN
GLYCINE+PUIDOXAL PO4
AMINOLAEVULINIC ACID
COPROPORPHYRINOGEN III
GSH
ACETATE SUCCINATE SUCCINYL CoAKreb’s Cycle CoA Mg++ ATP
+
(ALA)PORPHOBILINOGEN
ALA-DH
GSH
UROPORPHYRINOGEN I
COPROPORPHYRINOGEN
UD
PDUS
UROPORRPHYRINOGEN III
PDUS
UD
PROTOPORPHYRIN IX Fe++ + GLOBIN HAEMOGLOBINF-CH HS+
ALA-S
UO
ALA-S : Synthetase ALA-DH : DehydratasePD : Deaminase US : SynthetaseUD : Decarboxylase UO : OxidaseF-CH : Ferrochelatase HS : Haemoglobin SynthetaseGSH : Reduced Glutathione
![Relazione mandrino.rete.ppt [modalità compatibilità]...2019/05/08 · + thal α othal Hb S β thal δβ thal Hb Lepore Hb E Hb O Arab Hb C Hb D Punjab HPFH Not a carrier α+ thal](https://img.pdfslide.net/doc/110x75/5e9a890fb98c3712227912ea/relazione-modalit-compatibilit-20190508-thal-othal-hb-s-thal.jpg)
![Hemoglobin Tetramer [Hb(O 2 )] [Hb]P O 2 K 2 = [Hb(O 2 )] [Hb]P O 2 K 3 = [Hb(O 2 )] [Hb]P O 2 K 4 = [Hb(O 2 )] [Hb]P O 2 K 1 = = 4.88 = 15.4 = 6.49 =](https://img.pdfslide.net/doc/110x75/56649d5f5503460f94a3fa6a/hemoglobin-tetramer-hbo-2-hbp-o-2-k-2-hbo-2-hbp-o-2-k-3-hbo.jpg)
