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Healthy Mind, Healthy Sight.
Dr. Guy Eakin, BrightFocus Foundation
Dr. Elia Duh, Johns Hopkins University Dr. Seth Margolis, Johns Hopkins University
Healthy Mind, Healthy Sight.
BrightFocus Foundation
A Non-Profit Organization
Based in Clarksburg, Maryland
Supporting Research and Education to Save Mind and
Sight
One in 16 Americans, age 40 and above, has Alzheimer’s disease, macular degeneration, or glaucoma.
The Need for Cures is Great
Support Innovative, Cutting-Edge Research
BrightFocus has awarded more than 1,000 grants totaling $130 million. More than $26 million awarded in last four years.
Our Research Mission
Providing the Public with Information: Risk Factors Early Detection /Diagnosis Current Treatments Coping Strategies for Patients and Caregivers
Public Education
Glaucoma and Age-Related Macular Degeneration
Elia Duh, M.D.Wilmer Eye Institute
Johns Hopkins School of MedicineOctober 30, 2013
Glaucoma and Age-related Macular Degeneration (AMD)
Two of the most common causes of blindness in the United States
Risk factors:– AGE: especially over the age of 60– Family history– Race
Glaucoma
Glaucoma: – Fluid builds up in the
eye, so that the eye pressure rises
– This higher eye pressure can damage the optic nerve over time
Symptoms
Treatment
Research to improve treatments
Glaucoma
Age-Related Macular Degeneration (AMD)
AMD: – Eye condition among
people age 50 or older
– It gradually damages (and even destroys) the macula
Dry form of AMD
Wet form of AMD
Age-Related Macular Degeneration (AMD)
Symptoms
Treatments
Research to improve treatments for AMD
Alzheimer’s Disease
Dr. Seth MargolisJohns Hopkins University
Department of Biological Chemistry Johns Hopkins School of Medicine
October 30, 2013
Neurons
Synapses
Molecules
Behavior
Circuits
0 40 60 80 10020 (Years)
Genetic mutation andRisk factors
Misfolding and aggregation of Ab and tau followed by plaques and tangles
InflammatoryCell damage
Preventative
Modifying
Symptomatic
Cell death
Clinical diagnosis
Abnormal
Normal
Amyloid
NeuronInjury
Memory
DementiaMild
Daniel Colon-RamosKarl Deisseroth
Spine Abnormalities are a Hallmark of Cognitive Disorders
Reviewed in Ramakers et al. 2002, TINS
Unaffected Affected
Non-syndromic MRDown’s SyndromeRett SyndromeFragile X syndromePhenylketonuriaAngelman SyndromeAlzheimer’s disease
Spi
ne d
ensi
ty
Age
Wenbiao Gan
Dendritic Spine Density Changes with Development
anti-N-E5
anti-EphB2
Braak3 3 4 5 5 6Em
bryo
nic
86 82 93 102 89 88
Genetic Cross Between Alzheimer Mice Models and Ephexin5 Knockout Mice
X
Female Male
Electrophysiological properties:Dendritic spine morphology: Learning and memory:
Alzheimer MiceEphexin5-/Ephexin5-
Ephexin5-/Ephexin5+
Alzheimer’s
If You Have Questions…
Visit our website:www.BrightFocus.org
Send us an email:[email protected]
Give us a call:
1-800-437-2423