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908 H. G. FLOSS
CONCLUDING REMARKS
The foregoing review has hopefully shown that thebiosynthesis of the ergoline ring system, which at onetime looked like a simple sequence of mostly non-specificreactions, involves a substantial number of very specificand rather complicated transformations. It has also
Medicinal Chemistry and Pharmacognosy, particularly ProfessorsJ. M. Cassady, C.-j. Chang, P. F. Heinstein and J. E. Robbers, andwith a number of other research groups, particularly that ofProfessor D. Groger, Halle (Saale), to all of whom I am greatlyindebted. Finally I want to thank Mrs. Lorraine Smith for herskill and patience in typing this manuscript and drawing all thestructures.