Hematopoiesis Simplified: Part 1 Erythropoiesis

Larry Johnson Texas A&M University

Hematopoiesis Simplified: Part 1 Erythropoiesis

Objectives are to:• Identify the developmental cells of

erythropoiesis•Characterize developmental changes in the cytoplasm and nucleus of these cells

Bone marrow

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Blood vessel

Bone marrow

19761

Bloodin vessel

Peripheral blood

ErythrocytesReticulocytes

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Erythrocytes

Reticulocytes

Orthochromatophilicerythroblasts

Polychromatophilic erythroblasts

Basophilic erythroblasts

Proerythroblasts

No nucleus and red cytoplasm

No nucleus and blue - grey cytoplasm

Dark, small, spherical nucleusblue – grey cytoplasm

Darkening, fractured ,spherical nucleus and mixed pools of grey and blue cytoplasm

Fractured, spherical nucleus andthin rim of dark blue cytoplasm

Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm

Erythropoiesis

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Orthochromatophilic erythroblasts

Erythrocytes

Polychromatophilic erythroblasts

Basophilic erythroblasts

Proerythroblasts

Reticulocytes

Erythropoiesis

Erythropoiesis

Erythrocytes

Orthochromatophilic erythroblasts

Orthochromatophilic erythroblast

Erythrocyte

Polychromatophilic erythroblast

Basophilic erythroblast

Proerythroblast

Reticulocytes

Erythropoiesis

Polychromatophilic erythroblasts

Orthochromatophilic erythroblast

Erythrocyte

Polychromatophilic erythroblast

Basophilic erythroblast

Proerythroblast

Reticulocytes

Erythropoiesis

Basophilic erythroblast

Orthochromatophilic erythroblast

Erythrocyte

Polychromatophilic erythroblast

Basophilic erythroblast

Proerythroblast

Reticulocytes

Erythropoiesis

Proerythroblasts

Reticulocytes

ErythrocytesOrthochromatophilic erythroblastsErythropoiesis

Early orthochromatophilic erythroblasts

Late polychromatophilic erythroblasts

Polychromatophilic erythroblasts Early polychromatophilic erythroblasts

Basophilic erythroblasts Proerythroblasts

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Polychromatophilic erythroblast

Orthochromatophilicerythroblasts

Basophilic erythroblast

Proerythroblast

Late polychromatophilic erythroblast

Eosinophil orbasophil

RBCs

platelets

Reticulocyte

Erythrocytes

Bone marrow

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Reticulocyteenteringblood vessel

Blood vessel

The End of Hematopoiesis Simplified: Part 1 Erythropoiesis

• Granulopoiesis is next

Hematopoiesis Simplified: Part 2 Granulopoiesis

Larry Johnson Texas A&M University

Hematopoiesis Simplified: Part 2 Granulopoiesis

Objectives are to:• Identify the developmental cells of granulopoiesis•Characterize developmental changes in the cytoplasm and nucleus of these cells

Bone marrow32583

Bone marrow19761

Blood

Blood

`Bone marrow

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Developing granulocytes

21

Peripheral blood

Neutrophilicmetamyelocytes

Neutrophils

Neutrophilic myelocytes

Promyelocytes

Neutrophilic band or stab cells

Lobulated, dark nucleus, mature grey cytoplasm with small granules

Horse-shoe shaped, darkening nucleus, grey mature cytoplasm

Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent

Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules

Large, oval, non-indented nucleus,large amount of sky blue cytoplasm with non-specific granules

Granulopoiesis

Neutrophilicband cells

Neutrophils

Neutrophilic myelocytes

Promyelocytes

Neutrophilic metamyelocytes

Granulopoiesis

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Neutrophilic myelocytes

Neutrophilic metamyelocyte

Neutrophil

Eosinophil orbasophil

Platelets

Neutrophilic metamyelocytes

Neutrophilicband cells

Neutrophils

Neutrophilic myelocytes

Promyelocytes

Neutrophilic metamyelocytes

Granulopoiesis

Neutrophilic metamyelocytes

Neutrophilicband cellsLymphocytes Neutrophilic

myelocytes

Lymphocytes

Neutrophilic band cell

Unknown nuclei Promyelocyte

Neutrophilic myelocytes

Neutrophilic metamyelocytes

Neutrophilicband cells

Neutrophilic band cells

Neutrophils

Granulopoiesis

Early neutrophilicmetamyelocytes

Neutrophilicmetamyelocytes

Neutrophilic myelocytes

Late promyelocytes Promyelocyte

Neutrophilic metamyelocytes

Proerythroblast

Neutrophilic myelocytes

Neutrophilic metamyelocytes

Orthochromatophilicerythroblasts

Orthochromatophilicerythroblasts

Unknown nuclei

Eosinophils or basophils

Neutrophilicband cells

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White blood cell entering a blood vessel

Bone marrow

Blood vessel

Blood vessel

The End of Hematopoiesis Simplified: Part 2 Granulopoiesis