1. Hemophilia A Inherited blood disease where your blood doesnt
clot normally.
2. Cause
Lack of clotting factors
Hemophilia A (most common type)
Lack of clotting factor VIII
Passed on with X chromosome
1 3. Symptoms
Spontaneous bleeding
Large or deep bruises
Joint pain and swelling - internal bleeding
Random bleeding or bruising
Blood in urine
Nosebleeds
Tightness in joints
2 4. Symptoms
Emergency Signs
Sudden pain, swelling, and warmth of joints and muscles
Long and painful headaches
Constant vomiting
Fatigue
Neck Pain
Double Vision
3 5. Characteristics
Continuous bleeding after:
Injury
Surgery
Tooth extraction
4 6. Characteristics
More serious complications-
Bleeding into:
Joints
Muscles
Brain
Other internal organs
5 7. Characteristics
Lifelong Disease
8. Who Is Affected?
Women may be carriers
Passed down to children
Males have 50% chance of getting disease
Females have 50% chance of carrying disease
Hemophilia is mostly in men
Men only have one X-chromosome
All age groups
Mostly children
6 9. How It Normally Works Blood vessels are cut or damaged
Clotting factor recruits collagen
http://www.3dchem.com/molecules.asp?ID=195 8 7 Blood reacts to
clotting factors Platelets form plug at the injury site Bleeding
stops!! 11 10 9 How Disease Affects Homeostasis No clotting factor
to recruit collagen No clotting factor for blood to react to
Platelets dont form a plug Bleeding Does Not Stop! 12 10.
Diagnosis
Family history of hemophilia
Fetus testing
Blood testing from a child or adult
Diagnostic Testing
Carrier Testing
13 11. Treatment
Replacement of the missing clotting factor
Desmopressin
Injected into vein
Can be given as nasal medication
Helps body release factor VIII
14 12. Prevention
Cant be prevented
Genetic disorder
Genetic Counseling
Figures out the chance of your child getting hemophilia