High-shear mixer granulator systems Mixing, Granulating, Drying

Packaging Technology

High-shear mixer granulator systemsMixing, Granulating, Drying

2 | High-shear mixer granulator systems

Shortening the time between product development

and market launch and raising efficiency in production

while maintaining maximum quality are decisive

factors for our customers. The development of the

Hüttlin high shear mixer granulator responds to

precisely these demands. Gentlewing, SmartFlow and

UltraClean have become synonyms for innovative

technology for the benefit of customers. Gentlewing is

at the core of all Hüttlin units – available in an identical

design with bottom-drive or top-drive technology.

SmartFlowZ-shape of Gentlewing

Bottom Drive Top Drive

Superior mixing and granulation

Thanks to the patented Gentlewing impeller,

wall caking and incomplete emptying are

things of the past. The impeller shape matches

the contour of the mixing container and its

angled impeller plate ensures a forced mixing

Use the technological lead

High-shear mixer granulator

technology

of the product. The precise manufacturing

of the Hüttlin high-shear mixer granulator

ensures a defined granulation gap along the

entire length of the impeller plate, so

that a considerably larger surface is used

for granulation.

High-shear mixer granulator systems | 3

Form follows function

With the HTG (Hüttlin Top-Drive Granulator)

and HBG (Hüttlin Bottom-Drive Granulator),

Hüttlin has a high-shear mixer granulator

to meet every requirement. Gentlewing with

all of its benefits is available for use in

either version. The Hüttlin high-shear mixer

granulator with bottom drive is the best

Principle of the Gentlewing impeller

Granulation gap

choice for simple granulation applications in

combination with a fluid bed dryer. The top-

drive version satisfies the highest of demands.

A SinglePot application using UltraClean,

SmartFlow, vaccuum drying with solvent

recovery system can be extended with a high

containment design module.


HBG 600▶ Bottom Drive ▶ Inline operation▶ UltraClean – optional

HBG Hüttlin bottom drive high-shear mixer granulator

The innovative classic

Hüttlin has set another milestone with

its shaft seal design. Thanks to the

intelligent design and continuous flushed

seal, it is no longer necessary to lift or

remove the impeller for cleaning.

The combination of double lip seal and

wiper, flush seal, is designed as a

cartridge and has the same mounting

dimensions as the optional mechanical

seal. Consequently it can be easily

replaced. All of the GMP requirements

and pharmaceutical environment

standards are met. For easy cleaning all

utility connections are located in the

base frame of the machine. The lifting

mechanism of the container lid was

also developed with this in mind. The

lid is raised vertically to improve house

keeping in the process area.

Lifting mechanism

High-shear mixer Fluid bed


HTG 600 opened ▶ Top Drive ▶ SinglePot▶ Inline operation▶ UltraClean

HTG 600 with wet mill

HTG Hüttlin top drive high-shear mixer granulator

Innovation and GMP requirements

combined

The flexibility of a stand-alone unit as

a SinglePot or in combination with the

proven fluid-bed technology ensures

granulation and drying processes with

maximum efficiency.

The HTG high-shear mixer granulators

with top-drive technology differ from

those with bottom-drive technology

in that the seals of the Gentlewing and

chopper do not come into contact with

the product. This significantly reduces

wear and tear on the seal and the danger

of contaminating the product. HTG is

characterized by features such as lifting

columns for the product container,

the extreme ease with which cleanliness

can be checked, ultra-fast emptying times

and minimum effort in changing products.

Mixing, Granulating, Drying

SinglePot

High-shear mixer Fluid bed


Heated product container

Heated impeller shaft Heated lid SmartFlow,

360° strip gas feeding Discharge valve Gentlewing Chopper Temperature

measurement Cleaning nozzles Filter Vacuum pump Condensation unit Video camera

SinglePot: Consistent implementation of the benefits of top-drive technology

The Gentlewing along with the SmartFlow

continuous strip gas feeding system

replaces expensive, high-maintenance

accessories such as tilting options or

microwave technology with comparable

drying times. The wall installation enables

true separation of the GMP and technical

areas. All drives and supply lines can

be accessed via the technical area.

The logical consequence is to upgrade

this unit with the UltraClean (pat. pend.)

concept, split valves and additional

options from the Hüttlin product range

to create a genuine high-end

containment unit.

The SinglePot version of the Hüttlin high-shear mixer granulator combines

all of the benefits of the top-drive concept with the specific features

SmartFlow, heating jacket, product temperature regulation and vacuum

drying with solvent recovery. This concept meets the highest requirements

with regard to process times, product quality and handling.


From left to right: SmartFlow, metal filter, discharge valve

GMP-compliant design

There are things that do not compromise.

The Hüttlin high-shear mixer combines

a modular structure with implementation

of GMP requirements. The modular

structure offers maximum flexibility in

terms of adapting the unit to the specific

customer requirements. Consequent

implementation of the highest hygienic

requirements translates into a significant

increase in validation, cleaning and

production efficiency. When compared

with conventional high-shear mixer

granulators these are key benefits.

Gentlewing

▶ Maximum mixing quality with minimum mechanical stress on the product

▶ Minimum wall caking due to very close clearances between the product vessel and Gentlewing

▶ Excellent discharge due to Z-design of the Gentlewing impeller

▶ Effective drying without tilting or microwave technology

SmartFlow

▶ Highly efficient gas distribution over 360° for considerably higher drying homogeneity

▶ Shorter drying times due to continuous, effective strip gas feeding

Discharge valve

▶ The discharge valve design enables uninterrupted discharge, as the discharge velocity is not controlled by means of the valve opening, but by extremely low impeller speed

UltraClean

▶ The first CIP concept, which significantly reduces cleaning times and ensures highest cleaning quality


The variety in requirements on modern control systems means that it

must be possible to adjust them flexibly. Hüttlin’s control systems

were developed based on this premise. Their modular structure can be

adapted very easily, from control of an individual machine to entire

production lines and integration into ME-systems.

Based on a Siemens or Allan Bradley PLC,

the control system was consistently

developed according to GAMP guidelines

and is extended to include a PC above

a certain scope. Provicon fulfills all

requirements of the FDA 21 CFR part 11.

PAT Integration

Process monitoring is one of the most

important measures for meeting and

reproducing the required quality.

Device control and process monitoring

In addition to monitoring conventional

indicators such as temperature, torque,

pressure and flow rate for liquid binder

and strip gas, Hüttlin provides monitoring

of product humidity and particle size

distribution. A NIR (Near Infrared) sensor

can be integrated for inline monitoring

of the product quality, residual

humidity, mixing quality and particle

size distribution.


The cleaning requirements for high-shear mixer granulators from Hüttlin

can adapt to the customer’s process requirements. From WIP (Washing

in Place) to the CIP (Cleaning in Place) solution, the common denominator

for all of the cleaning concepts is efficiency.

Cleaning concept

Cleaning – WIP and CIP

Cleaning nozzle

M

Filter

Vacuum pump

High-shear mixer

Pneumatic filling

A 1

A 2E

B

C

DM

MA 1-2B CD EF

Cold water

Hot waterDI water

F

Detergent

To fluid bed


L

H

W

H

L

W

HTGHBG

Technical data subject to alterations *Depending on discharge container respectively discharge unit

Technical Data (Standard unit)

300 400 600 800 1 200 1 800

HBG

Total volume (litres) 300 400 600 800 1 200 1 800

Power (kW) 27 31 39 49 68 88

Length L (up to wall; mm) 1 800 1 845 1 925 2 120 2 600 2 650

Width W (mm) 1 400 1 460 1 560 1 560 2 160 2 200

Height H (mm)* 3 400 3 800 4 400 4 400 5 500 5 600

300 400 600 800 1 200 1 800

HTG

Total volume (litres) 300 400 600 800 1 200 1 800

Power (kW) 27 31 39 46 68 88

Length L (mm) 2 100 2 120 2 250 2 600 3 500 3 700

Width W (mm) 1 120 1 150 1 270 1 270 1 480 1 800

Height H (mm)* 3 100 3 200 3 500 3 600 4 050 4 200


Discharge valve HBG 600

Product overview / dimensions High-shear mixer granulator/dryer

HBG – Bottom Drive HTG – Top Drive

Standard systems HTG 300

HBG 400 HTG 400

HBG 600 HTG 600

HBG 800 HTG 800

HBG 1 200 HTG 1 200

HBG 1 800 HTG 1 800

UltraClean HTG 300UltraClean

HTG 400UltraClean

HTG 600UltraClean

HTG 800UltraClean

HTG 1 200UltraClean

HTG 1 800UltraClean

SinglePot HBG 300UltraClean SinglePot 300 SinglePot 300UltraClean

HBG 400UltraClean SinglePot 400 SinglePot 400UltraClean



HBG 1 200UltraClean SinglePot 1 200 SinglePot 1 200UltraClean

HBG 1 800UltraClean SinglePot 1 800 SinglePot 1 800UltraClean

Hüttlin GmbHA Bosch Packaging Technology Company

Hohe-Flum-Straße 42 79650 Schopfheim GermanyPhone +49 7622 6884-0Fax +49 7622 6884-111www.boschpackaging.com [email protected]

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High-shear mixer granulator systems Mixing, Granulating, Drying