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Dr H K Makker MBBS MD MRCP MSc MBA DM FRCP Consultant Respiratory Physician

North Middlesex University and University College London Hospitals London, UK

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Index Page number Personal details 3 Qualifications 3 Awards and Grants 3 Membership 3 Clinical 4-5 Appointments Training Experience Sleep Medicine Lung cancer Respiratory Medicine General and Acute Medicine Clinical audit &Guidelines Medico-legal Teaching 5-9 Appointments Experience Invited speaker, faculty member & course organiser Public and media engagement Research 10-16 Appointments Experience Management Editorial board member, Grant/Programme and Peer reviewer Conference chair Collaboration Supervision Presentation at Scientific meetings Publication 17-19 Books Book chapter Review Original papers and case reports

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Date of Birth: 30 November, 1959 Nationality: British GMC No: 3411230 MDU No: 199376J Address Work: University College London Hospital Department of Thoracic Medicine 4th Floor, East Wing, 250 Euston Road, London NW1 2PG, United Kingdom

Tel-0203 4567890 e-mail- himender.makker@nhs.net Secretary: Donna Basire Tel: 020 3447 9473 Fax: 020 3447 9476 e-mail-donna.basire@nhs.net

North Middlesex University Hospital NHS Trust Department of Respiratory Medicine, Clinic 1 Sterling way, Edmonton, London N18 1QX Tel 02088872000 e-mail- himender.makker1@.nhs.net

Secretary: Suzanne Dacosta Tel 02088873581 e-mail-suzanne.dacosta@nhs.net The London Clinic 5, Devonshire Place, London W1G 6HL Tel 02079354444 Secretary: Robyn Smith Tel 07730145512 e-mail: drmakkersecretary@hotmail.com Correspondence: The Glebelands 117 Barnet Road, Arkley, Barnet, London EN5 3JF Tel: 07702372182 e-mail himendermakker@gmail.com

2006 Postgraduate Diploma LSHTM, London, UK 2005 MSc (Epidemiology) University of London, UK 2005 MBA (Health Services) Greenwich School of Management, University of Hull, UK 2001 FRCP Royal College of Physicians, London, UK 1996 CCST (Gen &Res Med), General Medical Council 1994 DM University of Southampton, UK 1987 MRCP Royal College of Physicians, London, UK 1986 MD (General Medicine) University of Delhi, India. 1982 MBBS University of Delhi, India

1998 North Middlesex University Hospital (NMUH) Trust Chairman’s 2001 NMUH-High Intensity Work Supplementation award 2010- NMUH-Clinical Excellence award (Level 5) 1999 Project grant £5,000 by R&D committee of North Middlesex hospital 2001 Research Grant £ 70,000, CRDC, UCLH Special Trustees 1999 Lung Cancer Service Annual Funding £ 44,000, NHS Executive

2008 Sleep Service Annual funding £170,000, Enfield &Haringey PCT American Thoracic Society, Anglo-French Medical Society British Society of Thoracic Oncology, British Thoracic Society, British Sleep Society, British Medical Association, Expert Witness Society, European Respiratory Society International Association for Study of Lung Cancer, Royal Society of Medicine

QUALIFICATIONS

AWARDS AND GRANTS

MEMBERSHIP

PERSONAL DETAILS

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CLINICAL APPOINTMENTS 1997- Consultant Respiratory Physician

North Middlesex University and University College London Hospitals, London 1998-2017 Clinical Lead for Lung cancer Service

North Middlesex University Hospital 2008- Clinical Lead for Sleep Medicine Service

North Middlesex University Hospital 1997-99 Consultant Respiratory Physician (Honorary)

Royal National Throat Nose and Ear Hospital, Gary’s Inn Road, UCL, London CLINICAL TRAINING 1994-96 Senior Registrar in Respiratory Medicine

Birmingham Heartlands &City Hospitals, Birmingham & Hope Hospital, Manchester 1991-93 Post-Doctoral Clinical Research Fellow

Southampton General Hospital, Southampton 1990 Registrar in Respiratory Medicine

Salford Royal and Hope Hospitals, Manchester 1989 Registrar in Respiratory Medicine

Llandough Hospital, Cardiff 1987 Registrar in Respiratory Medicine

St. Anne's and North Middlesex Hospitals, London 1986 Senior House Officer

Respiratory & General Medicine, Hertford County Hospital, Hertford Derriford General Hospital, Plymouth

1985 Senior Resident Cardiology Dr. R.M.L. Hospital, New Delhi, India

1983-84 Post-Graduate/ Junior Resident in General Medicine Dr. R.M.L. Hospital, New Delhi, India

1982 Junior Resident Cardiology &Orthopaedics G.B. Pant & L.N.J.P. Hospitals, New Delhi, India

1981 Internship L.N.J.P. Hospital, New Delhi, India

CLINICAL EXPERIENCE Sleep Medicine Clinical Lead for Sleep Medicine Service Established sleep services at UCLH and NMUH Developed pathways and prepared guidelines for sleep service Raised awareness of sleep disorder among public, primary care physician and non–sleep specialist Collaborated with multidisciplinary UCLH Sleep Group Coordinated with Bariatric and ENT surgeons at UCL Lung cancer Lead clinician for lung cancer service Provide multi-professional, and integrated lung service for Enfield and Haringey population Produced framework for the service and local guidelines to Implemented National Lung Cancer Guidelines Carried out Patient’s satisfaction survey Introduced bronchoscopy reporting program and EBUS service Performed clinical audit of service to identify the gaps in the service Represent at Cancer Services Committee, North London Tumour board network and London Lung Cancer Group.

CLINICAL

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Respiratory Medicine Respiratory emergencies, Non-invasive ventilation, Bronchoscopy, chronic severe and exercise-induced asthma Acute and General Medicine Provided acute medical take service CLINICAL AUDIT National National COPD Audit 2003 BTS & RCP National Lung Cancer Audit 1999-2017 BTS &RCP Local Delay in diagnosis of Lung cancer and local guidelines for management of lung cancer 1998 North Middlesex University Hospital Oxygen use at oxygen use on respiratory ward & published recommendations 1996 On behalf of Clinical Audit and Standards Committee Birmingham Heartlands Hospital Management of spontaneous pneumothorax 1995 Produced and published local guidelines Birmingham Heart Hospital Usefulness of Wang’s needle aspiration biopsy for diagnosis of lung cancer 1994 Hope Hospital, Salford Manchester 1994 Outcome of bronchoscopy for suspected lung cancer 1994 Hope Hospital, Salford Manchester 1994 Management of community acquired pneumonia 1990 Produced local guidelines, Salford Royal Hospital Home nebuliser use 1989 Produced local guidelines for prescription of home nebuliser at Salford Royal Hospital

MEDICO-LEGAL EXPERIENCE Respiratory Disability Assessment for Diseased Coal Miners 2001-2 Health Call, Department of Transport and Industry (DTI), London Asbestos pleural plaques 2004-5 Industrial Lung Disease Ltd, London Obstructive Sleep apnoea 2008- DVLA Respiratory medicine expert 1999- Windsor Medical Legal, Windsor Member, Action Against Medical Accidents (AVMA) 1998 Member, Society of Expert Witness 1999 Expert Witness Skills –How to avoid the pitfalls 2018 A Joint Royal Society of Medicine & BPP University School of Health Master Class

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TEACHING/EDUCATION APPOINTMENTS 1999-2010 Senior Lecturer in Medicine

Royal Free & UCL Medical School, London 2000- Associate Professor in Medicine

George’s University Medical School, West Indies 2006-7 Visiting Professor in Medicine St Georges Medical School University Hospital, West Indices 2000-11 Program Director- Undergraduate Medical students St George’s University Medical School and UCL Medical School, North Middlesex University Hospital, London 1998-2000 Vice-President (Education) British Medical Association Enfield & Haringey Division, London 2013 External Final Year Medical students Examiner Malta Medical School, Malta 2001-2012 Undergraduate OSCE Examiner Royal Free and UCL Medical, London 2001-2012 Undergraduate Clinical Skills Examiner St George’s University Medical School, West Indies 2003-2013 MRCP-PACES Examiner Royal College of Physicians, London 2003 RCP Representative for Consultant Advisory Appointment Committee Royal College of Physicians, London 2008 Chair and Sleep Medicine Course Organiser UCLH, London 1998-2017 Clinical and Education Supervisor Core Medical Trainees

North Middlesex University Hospital, London 2014-16 Respiratory Medicine Trainee (SpR) Supervisor NE Thames and European Visiting, North Middlesex University Hospital NHS Trust 2013 Visiting Consultant Respiratory Physician Supervisor North Middlesex University Hospital NHS Trust, London TEACHING AND EDUCATION EXPERIENCE 1998 Royal Free and University College London Medical School

Senior Lecturer in Medicine UCL Final Year medical students OSCE Examiner UCL Snoring and Sleep Apnoea Course-Faculty Member and Speaker UCL Advanced Neurology Sleep Medicine Course-Faculty Member and Speaker UCL Respiratory Medicine for Spanish Doctor-Speaker UCL MSc Life Sciences Respiratory Course-Speaker UCLH Annual Sleep Medicine Course –Organiser, Chair and Speaker

1997 North Middlesex University Hospital NHS Trust-Associate Teaching Hospital

Education Supervisor Final Year UCL students SHIFT visit organiser Educational Supervisor House Officer and SHO (Foundation and Core Medical Trainees) House Officer & MRCP Teaching (Foundation and Core Medical Trainees), Medical Grand Round

1998 Specialist Registrar Training Program –North East Thames

Study day Organiser and Speaker at London Chest, Royal Free North Middlesex University and University College London hospital

TEACHING /EDUCATION

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1998 Primary Care Education North London GP forums Essentially Medicine GP Education Program BMA GP Education Program (BMA House and St Anne Hospital) Primary Care Trust-Protected Learning Time Education (Enfield and Haringey PCT and Islington PCT) North Middlesex University Hospital NHS Trust GP meeting

2001 Royal College of Physicians, London

MRCP PACES Examiner College Representative on Advisory Appointment Committees Nomination for MRCP Examiner and FRCP

2007 General Medical Council

Validate to assess Fitness to Practice Test of Competence 2000 St Georges University Medical School, Grenada, West Indices

Program (Clerkship) Director, North Middlesex University Hospital NHS Trust Organisation of Medical School Inspection visit, North Middlesex University Hospital Associate Professor in Medicine, St George University, Grenada, West Indices Visiting Professor Kingstown Medical School, St Vincent, West Indices Clinical Skill Assessment Examiner Watford General Hospital, London SGUSOM UK Clinical Faculty Meeting, Winchester, UK SGUSON Senate Meeting, Grenada, West Indices

2010 Malta University, Medical School and Mater Dei Hospital

Visiting External Examiner for Final Year Medical Students Guest Speaker at Malta Association of Physicians Guest Speaker, and Chair at Malta Medical Conferences Guest Speaker and Chair Malta Respiratory Conference Malta Medical Student Elective Organiser- North Middlesex University Hospital NHS Trust Malta Higher Specialist Training- Clinical Fellow Supervision and clinical Elective

INVITED SPEAKER, FACULTY MEMBER AND CONFERNCE ORGANISER 2018 Holborn Medical Centre London

GP Group Practice Talk “Asthma and COPD Overlap Syndrome” 2018 UCLH Advanced Sleep Medicine Course, London

Course Organiser, Chair and Speaker 2018 Respiratory Symposium, Medical Association of Malta

Key note speaker on Lung Cancer and Sleep apnoea 2017 UCLH Advanced Sleep Medicine Course, London

Course Organiser, Chair and Speaker 2016 National Sleep Medicine Course, Dehradun, India Faculty member and Speaker 2016 National Sleep Technology Course, New Delhi, India Faculty member, Chair and Speaker 2016 South Thames Respiratory Specialist Registrar “Sleep Medicine” Study Day, Maidstone

Course organiser and Speaker 2016 National Course of Molecular and Cellular Biology in Pneumology (BIOCEP) – Naples, Italy

Guest Speaker and Faculty Member 2016 Sleep and NIV Forum, London

Organiser and Chair 2016 UCLH Sleep Medicine Course, London

Course Organiser, Chair and Speaker 2015 National Sleep Medicine Course, Assam, India

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Faculty member and Speaker 2015 National Sleep Technology Course, New Delhi, India Faculty member, Chair and Speaker 2015 Sleep and NIV Forum, London Founder, Organiser and Chair 2015 British Academic Conference in Otolaryngology (BACO2015), Liverpool Speaker-Non Surgical Treatment of Obstructive sleep -apnoea 2015 UCLH Sleep Medicine Course, London

Course Organiser, Chair and Speaker 2014 Asia Pacific Society of Respirology (APSR) Conference, Bali, Indonesia

Speaker-Post graduate course &symposium, Faculty member & chair of scientific session 2014 Malta Medical Association Conference, Malta

Guest Speaker-Treatment Targets in Obstructive Sleep Apnoea 2014 Essential Medicine for Lawyers Course, AVMA, London

Invited Speaker 2014 UCLH Sleep Medicine Course, London

Course Organiser, Chair and Speaker 2014 NE Thames Respiratory Specialist Training Day North Middlesex University Hospital

Speaker 2013 UCL MSc Respiration in Life, Health and Disease module, London-

Speaker 2012 Malta Medical Association Conference, Malta

Guest Speaker, Faculty Member & Chaired scientific sessions 2012 NE Thames Respiratory Specialist “Sleep and Ventilation” Study Day, London Organizer and Speaker 2012 Advanced Neurology Short Course, Sleep UCL “Sleep Disordered Breathing”, London

Invited Speaker 2012 GP Protect Learning meeting “Obstructive Sleep Apnoea” NHS North London

Invited Speaker 2011 NAPCON-National Conference on Pulmonary Disease .New Delhi, India

Guest Speaker and Faculty Member 2011 UCLH Group Sleep Course, London, Course Organiser,

Course Organiser, Chair and Speaker 2011 UCL Ear Institute- “Snoring and Obstructive Sleep Apnoea Course”,

Faculty member &Invited speaker 2010 NE Thames Respiratory Specialist “Sleep” Study Day, UCLH, London

Organizer and speaker 2010 Medical Association of Malta “Respiratory Update Conference

Guest Speaker, Faculty Member and Chairman of scientific sessions 2009 The Medical Update Group, University of Mauritius, Mauritius

Invited Speaker 2009 Snoring and Sleep Apnoea Course, Royal National Throat Nose and Ear hospital, UCL.

Speaker and Faculty Member 2009 Sleep Education Meeting, St Thomas Hospital, London

Invited Speaker 2008 SEAR-NATCON (South East Asia Region & National Association of Tuberculosis and Chest

Diseases) Conference, New Delhi, Guest Speaker, Faculty Member & Chair 2006 Central European Lung Cancer Conference, Prague

Invited Speaker 2005 BROCON (National Annual Conference on Bronchology, Indian Association for Bronchology)

New Delhi, Invited speaker and Faculty Member 2003 English for Respiratory Medicine Course, UCL

Faculty Member and Invited Speaker 2001 Snoring and Sleep Apnoea –Recent advances RF &UCMS Speaker and Faculty Member

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2001 NE Thames Respiratory Specialist Registrar Study Day, The Middlesex Hospital. Organiser and Speaker

2000 Anaesthetist Association, Bombay, India Speaker- Perioperative Management of Asthma 1999 Mauritius Medical Council, Mauritius Speaker 1998 NE Thames Respiratory Specialist Registrar Study Day, The London Chest hospital. Speaker Bronchoscopy for lung cancer 1997 Introductory Medicine Course, Birmingham University Medical School

Speaker 1993 Respiratory and Cardiovascular system course Southampton University Medical School. Speaker 1989 Diploma Course in Tuberculosis and Chest Diseases, University of Wales College Medicine Speaker and Clinical Tutor PUBLIC AND MEDIA TALKS 2013 BMI Garden Hospital, Hendon, London- Press release “It time to wake up and tackle

Barnet’s night -time menace” Snoring and Sleep Apnoea-Awareness 2011 Oswald Health Awareness Day, Hertfordshire- Invited Speaker 2010 The Times Newspaper, Malta, Newspaper Interview 2001 Bugs –Good, Bad and Ugly –Talk- Year 6 students at the Brooklands School,

Hampstead Garden Suburb, London 2003 BBC Sports 94.9 Live interview with Danny Kelly organised on Sleep Disorders. 2000 North London Italian Community Event to raise money for lung cancer service at the

North Middlesex University Hospital raised £ 2400 1999 Lions Club Southgate Charity event by local MP to donate lung function equipment

to the North Middlesex University Hospital- Organised the visit 1999 Organised Public Lecture on Sarcoidosis for patients- to raise the awareness of

Sarcoidosis among local community 1994- Brittle Asthma Interview on Channel 4 TV Program on Management of Asthma-ert

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RESEARCH APPOINTMENTS 2015-17 Member Program Review Subcommittee-American Thoracic Society

Orlando & San Antonio, USA 2006-7 Smoking Cessation Project Advisor to NHS London Health Observatory

London, UK 2003-9 Vice-Chairman & Member Research Ethics Committee

Barnet, Enfield, Haringey Local Research Ethics Committee, London 2001-5 Director, Research & Development

North Middlesex University Hospital NHS Trust, London 2015-17 Founder and Chair-London Sleep and NIV Forum

London, UK 1998- Research Collaborator& Supervisor for MSc and MD

North Middlesex University and University College London Hospital 1992 Editorial board member & Peer Reviewer for Scientific Journals

London, UK RESEARCH TRAINING 2002-5 Clinical and Cancer Epidemiology, Biostatistics and Clinical Trail Training Courses LSTMH, UCL Trial Unit, London, UK an IARC, Lyon France 2002-5 MSc in Epidemiology Dissertation Project “Effect of ethnicity on Outcome of lung cancer” LSHTM, London 1991-93 Post-Doctoral Clinical Research Fellow Thesis on Mechanism of Exercise-induced Asthma, Southampton 1983-85 Post-Graduate in General Medicine MD Thesis “Effect of selective and non-selective beta blocker on blood sugar in Diabetes mellitus” University of Delhi, India

RESEARCH MANAGEMENT 2001-5 Director of Research and Development North Middlesex University Hospital, London Chaired R&D committee meetings for approval of research projects

Formulated Local R&D strategy to meet National R&D Priorities Prepared R&D report quarterly for the trust board & annual report for regional NHS R&D Implemented Research Governance Established partnership with primary care research group and Clinical Research Network Supported by Trust for MBA in Health Sciences and MSc in Epidemiology and formal training on statistics MBA Dissertation-Impact of government’s reforms on outcome of lung cancer in the United Kingdom MBA (Health Services Management) University of Hull, UK -2004

2003-9 Co-Vice chairman & Member of Barnet, Enfield and Haringey Ethics Committee, London

Review and approve research projects Chair and co-ordinate meeting Contribute to discussion on research policy

2006-9 Expert Advisor, London Health Observatory

Prepared review on “Smoking Cessation interventions and Strategies: Does ethnicity matter? London: North Middlesex and University College Hospitals, 2006

RESEARCH

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Attended and contributed to task force meeting on Equity of access to London’s stop smoking services Contributed to paper on “Commissioning for equity Stop Gaps– Equity of access to London’s stop smoking services”- London Health Observatory; September, 2009

EDITORIAL BOARD MEMBER & GRANT/PROGRAMME APPLICATION AND PEER REVIEWER Editorial Board Member 2017 International Journal of Allergy and Asthma 2016- International Journal of Pulmonary and Clinical Research 2015- Sleep Science 2000-4 Capitol Doctor 2009 Foundation Trainee Journal Grant Application Reviewer 2017 National Institute of Health Research (NIHR) Randomised controlled trial of nasal decongestants versus placebo to prolong treatment free periods from continuous positive airway pressure therapy in mild to moderate obstructive sleep apnoea 2015 Medical Research Council (MRC) 2015 The cardiovascular consequences of obstructive sleep apnoea 2015-17 American Thoracic Society Member of Program Subcommittee member Primary reviewer of four programs and secondary reviewer of three programs Participated in Web meeting on guidelines and process of reviewing Discussed at Program Review Subcommittee meeting at Orlando and St Antonio Peer-reviewer American Journal of Critical Care and Respiratory Medicine British Medical Journal, Chest, Capitol Doctor, Clinical and Experimental Allergy European Respiratory Journal, European Journal of Clinical Nutrition Foundation Trainee Journal , Journal of Applied Physiology ,Sleep Science

RESEARCH CONFERENCE CHAIR 2018 European Respiratory Society Conference, Paris France Thematic Poster Sessions- Non-invasive ventilation for acute respiratory failure Treatments that can serve as an alternative to positive airway pressure (PAP) 2014 Asia Pacific Society of Respirology (APSR) Conference, Bali, Indonesia Respiratory Neurobiology and Sleep Assembly: Oral session 2012 Medical Association of Malta Conference, Malta

Scientific session- Oral presentation-Respiratory Medicine session 2011 NAPCON-National Conference on Pulmonary Disease, New Delhi, India

Faculty Member and chaired scientific session 2010 Medical Association of Malta “Respiratory Update Conference”

Chairman of scientific sessions 2008 SEAR-NATCON (South East Asia Region & National Association of Tuberculosis and Chest Diseases) Conference, New Delhi, India

Role of sleep in lung health and disease and Panel discussion on COPD

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RESEARCH COLLABORATION 1992-2000 Clinical Drug Trials-Principle Investigator and collaborator with Pharmaceutical

Companies Southampton General Hospital, Birmingham Heartlands Hospital and North Middlesex University Hospital

1999-2000 Big Lung TrialThe Big Lung Trial (BLT): A major randomised trial to determine the value of cisplatin-based chemotherapy for all patients with non-small cell lung cancer (NSCLC), CRC Trial London Co-Investigator/Collaborator-North Middlesex University Hospital 2000-2003 The molecular genetics of pulmonary fibrosis- Functional PTFG2 polymorphism

predicts the outcome of Sarcoidosis Centre for Respiratory Research Project UCL Collaborator-North Middlesex University Hospital.

2003-2005 Near Infra-Red spectroscopy in Sleep Apnoea- Biomedical Optical research

laboratory Principle Investigator at the UCLH 2009-2010 REMEDY-A Clinical Trial of Endobronchial Ultrasound for diagnosis of Mediastinal

Lymphadenopathy. Sam Janes, Neal Navani and Gerald Silvesteri UCL, Collaborator at the North Middlesex University Hospital

2010-2012 BOOST (Bronchoscopic or Oesophageal Staging of Lung Cancer) Trial- A New

diagnostic pathway for the rapid diagnosis and staging of lung cancer in a single test-a randomized controlled trial. Principle Investigator at the North Middlesex University Hospital

2010-2013 Improvement in Lung Cancer Outcome Project (ILCOP) Project, Royal College of

Physicians, London, Principle Investigator, North Middlesex University Hospital 2017 The SUMMIT study is part of a UK and US collaborative multicenter

prospective cohort study to aide early cancer detection in conjunction with LDCT by assessing the presence of cell-free tumour DNA and other types of early cancer detection assays. Professor Sam Janes UCL

Principle Investigator, North Middlesex University Hospital 2018 IDEAS (Identification of DEterminants of Altered circadian rhythm) study A multicentre study Chief Investigator Professor Frances Levi, University of Warwick. Evaluation of objective and patient-reported determinants of disruption of the Circadian Rest-Activity Rhythm (Low Dichotomy Index I<O): A multicentre observational study. Collaborator at UCLH,

RESEARCH SUPERVISION 2018 Dr. Francesca Simioli Visiting Registrar in Respiratory Medicine, Naples, Italy 2016 Dr. Angelo Canora, Visiting Specialist Registrar in Respiratory Medicine, Naples, Italy 2015- Dr. Catherine Eweka Clinical Research Fellow Tracheal Dimensions in OSA 2014-15 Dr. Giovanni Fiorino, Clinical Research Fellow (Messina, Sicily, Italy) 2013-14 Dr. Raluca Macvei, Clinical Research Fellow (Bucharest, Romania) 2011-12 Dr. Vladimir Macvei- Clinical Research Fellow (Visiting Clinical Fellow from

Bucharest, Romania)-Predictors of OHS, Obstructive Sleep Apnoea& Polycythemia 2011-12 Dr. Kirit Panesar Sleep and Neuromuscular disorders 2009-10 Dr. Christopher Zammit, Clinical Research Fellow, (Higher Specialist Trainee Malta)

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Acute NIV in Obesity Hypoventilation, Hypoxic Challenge in OSA, 2007-8 Dr John Griffith “Clinical Fellow Inhaled corticosteroids in COPD” 2005-7 Dr Z Tariq Clinical Fellow “Tumour doubling time” 2004-5 Dr Dennis Chairman- Ethnicity and Outcome of Lung Cancer 2002-4 Dr Joanne Kosmin Clinical Fellow Ethnicity and Outcome of Lung Cancer 2003 Dr She Wang Visiting Research Fellow (China) Obstructive sleep apnoea 2003 Mr Kristopher Spurling, Lung Function Technician “Breathlessness in COPD 2000-3 Dr Ann McGowan, Clinical Research Fellow MD Project - Mechanism(s) of

neuropsychological impairment in sleep apnoea using near infrared spectroscopy 2000-1 Dr Zelma Hall, Clinical Research Fellow “Epidemiology studies in Pneumothorax and

Pulmonary Embolism 1999-2000 Dr Arachang Valipour Visiting Research Fellow (Vienna) GORD in OSA 1998-99 Dr Tudor Toma, European Respiratory Society Fellow.GORD in COPD 1998-89 Stephen Emegbo, Pulmonary function technician. MSc Project (Brunel University) -

Role of Nasal Dilator in exercise -induced asthma 2006 Thesis Co-Supervisor, Dr Anne McGown “Assessment of cerebral oxygenation using

near infrared spectroscopy in obstructive sleep apnoea & chronic obstructive pulmonary disease” MD Thesis, University College London

PRESENTATION AT SCIENTIFIC CONFERENCES

Ali N, Makker H, Cockwell P et al. Radial artery puncture - A comparison of three Haemostatic techniques British Thoracic Society Thorax 1989; 44: 879A. Makker HK, Carroll M, Gratziou C, Walls AF, Varley JG, Howarth P, Holgate ST- Local endobronchial hypertonic challenge in patients with exercise-induced asthma. American Thoracic Society Am Rev Respir Dis 1992;145(4):A729. Makker HK, Holgate ST- The effect of ipratropium bromide, atropine and lignocaine on bronchoconstriction induced by hypertonic saline in asthmatics. American Thoracic Society Am Rev Respir Dis 992;145(4):A57. Varley JG, Makker HK, Carroll M, Gratziou C, Walls AF, Howarth P, Holgate ST. Aerosol delivery through a fibre-optic bronchoscope and its use in endobronchial challenge in asthmatic subjects. American Thoracic Society, Am Rev Respir Dis 1992;145(4):A730. Rajakulasingham, Makker HK, Church MK, Holgate ST, Howarth P. Tachyphylaxis to inhaled bradykinin in asthma: its relationship to basal airway responsiveness. American Thoracic Society Am Rev Respir Dis 1992;145(4):A729. Makker HK, Crome R, He SH, Lau LCK, Holgate ST. Effect of potassium channel activator R0316930 on histamine reactivity in asthmatic subjects. European Respiratory Society Eur Respir J.1992:5;215s. Makker HK, Holgate ST. Hypertonic saline responsiveness relates to exercise-induced asthma symptom severity rather than to histamine or methacholine reactivity. American Thoracic Society Am Rev Respir Dis 1992;145(4):A730. Rajakulasingham, Makker HK, Church MK, Howarth PH, Holgate ST. Cross refractoriness between bradykinin and hypertonic saline challenges in asthma. British Thoracic Society Thorax 1992;47:873. Makker HK, Lau LC, Thomson HW, Binks SM, Holgate ST. The protective effect of inhaled

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LTD4 receptor antagonist ICI 204,219 against exercise-induced asthma. American Thoracic Society, Am Rev Respir Dis 1993;147:A297. Makker HK, Walls AF, Goulding D, Montefort S, Carroll M, Howarth PH, Holgate ST. The effect of local airway challenge with hypertonic saline on mast cell mediator release and epithelium. Am Rev Respir Dis 1993;147:.A665. Makker HK, Montefort S, Ghatei M, Bloom SR, Springall DR, Polak JM, Howarth PH, Holgate ST.Local airway challenge with hypertonic saline: Effect on epithelial structure and endothelin release. Eur Respir J 1993;6:265s. Makker HK, Ghatei MR, Bloom SR, Springall DR, Polak JM, Holgate ST, Howarth PH. Bronchoconstriction following local endobronchial challenge with hypertonic saline is associated with reduced endothelin levels in lavage. Eur Respir J 1994;7:51s. Aldridge RE, Makker HK, O'Driscoll BR. Outcome of bronchoscopy for suspected lung cancer in a university general hospital. Thorax 1994;49:1060P. Walls AF, Djukanovic R, Walters R, Brander ML, Makker HK, Gratziou C, Carroll MP, Frew AJ, Pritsinas K, Lampe FC, Howarth PH, Holgate ST. Mast cell, eosinophil and neutrophil activation in the lungs of asthmatic patients. Am J Respir Crit Care Med 1995;151:A 38. Tunnicliffe WS, Duncanson RC, Fletcher TJ, Makker H, Welch J, Jones M, Ayres JG. Site Problems in type 1 brittle asthmatics using continous subcutaneous infusions of terbutaline (CSIT). Am J Respir Crit Care Med 1996;153: A 520. Makker HK, W.Tunicliffe, R.Duncanson, T.Fletcher, JG Ayres. Effect of single dose inhaled frusemide on airway size in severe asthma. Am J Respir Crit Care Med 1996;153: A 345. Wales D, McDowell P, Makker H, Kane J, O' Driscoll BR. Suppresion of serum cortisol by High dose inhaled corticosteroids: Effects of three drugs and delivery system. ERJ1996;9; 23(suppl):163s. Makker HK, Edenborough FP, Stableforth DE. Hypomagnesemia in cystic fibrosis patients with type II respiratory failure admitted with chest infection. Pediatric Pulmonology 1996;( Supplement 13): 402. Wales D, Mc Dowell P, Makker H, Kane J, O' Driscoll BR. Systemic effect of High dose budesonide (4 mg) taken by four inhaled system and orally. Thorax 1996;51(supplement 3 ): A 72. Wales D, Mc Dowell P, Makker H, Kane J, O' Driscoll BR. Systemic effect of high dose Inhaled steroids (Budesonide, Beclomethasone, and Fluticasone) taken via large volume spacer. Thorax 1996; 51(supplement 3): A 71. Makker H, Edenborough F, Jones A, Stableforth D. Symptomatic hypomagnesaemia in cystic fibrosis precipitated by treatment of infection. Thorax 1996;51(supplement 3): A 48. Toma TP, Emegbo S, Spiro SG, Makker HK. Gastroesophageal reflux disease (GORD) in Patients with sleep disordered breathing. European Respiratory Journal 1999,14(Supplement):87s. Royston R, Grant H, Spiro SG, Makker HK. Non-invasive measurement of intracranial pressure in patients with sleep-disordered breathing. European Respiratory Journal 1999;14(Supplement):87s.

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Makker HK, L’ Estrange PR, Grant H, Spiro SG. Sleep-Disordered breathing in Scheie’s Syndrome cephalometeric features.European Respiratory Journal 1999; 14(Supplement):87s. McGown A, Makker HK, L’ Estrange PR, Toma TP, Spiro SG. Questionnaire follow up of mandibular advancement splint (MAS) for more than one year. European Respiratory Journal 1999;14(Supplement):355s. Toma TP, Spiro SG, Makker HK. Gastroesophageal reflux disease (GORD) in patients with Asthma and COPD attending chest clinic. European Respiratory Journal.1999;14 (Supplement) : 387s. L’ Estrange PR, Smith C, Grant HR, Makker HK, Spiro SG. Pilot randomised trial of nasal Continuous positive pressure (CPAP) ventilation versus a mandibular advancement splint in severe obstructive sleep apnoea (OSA): Early difficulties. European Respiratory Journal 1999, 14(Supplement):408s. Makker HK, Toma TP, Emegbo S, Papesh M, Croft C, Spiro SG. Comparison of acoustic reflection technique with nasendosocpy for evaluation of upper airway size in awake patients with sleep disordered breathing (SDB). European Respiratory Journal 1999,14 (Supplement):495s. R Ng, Costantinovici, Makker HK. Relationship between spontaneous pneumothorax hospital admissions and atmospheric pressure changes. European Respiratory Journal;1999,14(Supplement):512s. Valipour A, Makker H, Emegbo S, McGown A, Smith C, Sprio SG. Cerebral oxygenation in patients with Obstructive sleep apnea. American Journal of Respiratory Medicine and Critical Care 2000, 161A483. Embego S, Valipour A, Spiro SG, Makker HK. Nasal dilator strips and exertional breathlessness in asthmatics. European Respiratory Journal 2000, 31(Supplement):84s. Valipour A, Wong KY, McGown A, Embego S, Sprio SG, Makker HK. Gastro-oesophageal reflux (GOR) and risk factors in subjects with sleep apnoea-hypnoea syndrome (SAHS). European Respiratory Journal 2000, 31(Supplement):167s. McGown AD, Valipour A, Makker HK, Emegbo, Delpy DT, Spiro SG. Measurement of changes in cytochrome oxidation state during obstructive sleep apnoea using near infrared spectroscopy (NIRS). European Respiratory Journal 2000, 31(Supplement):167s. Valipour A, McGown A, O, Sullivan, Makker H, Spiro SG. Non-invasive measurements of cerebral oxygenation during sleep in subjects with obstructive sleep apnoea (OSA). Thorax 2000;55(Supplement 3): A24. McGown A, Valipour A, Makker H, Spiro SG. Measurement of cerebral oxygenation during Oxygen challenge in chronic obstructive pulmonary disease (COPD) using near infra-red spectroscopy. Thorax 2000;55(Supplement 3):A41. Hall Z, Makker HK. Relationship between subjective and objective improvement in breathlessness with nebulised bronchodilators in COPD. ERJ 2001 Supplement Hall Z, Makker HK. Relationship of spontaneous pneumothorax hospital admissions and environmental Factors. American Journal of Respiratory Medicine and Critical Care 2002:(Supplement).

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McGown AD, Al-Rawi PG, Makker HK, Spiro SG, Kirkpatrick PJ. Cerebral oxygenation Onitoring during obstructive sleep apnoea reflects changes in cerebral blood flow velocity as well as arterial oxygen saturation changes. European Respiratory Journal 2002:20 (Supplement 38): 295s. Luo YM, McGown A, Makker H, Spiro SG. Reproducibility of the OSLER Test. American Journal of Respiratory Medicine and Critical Care 2003; (Supplement) Hall Z, Makker HK. Seasonal variations in the incidence of pulmonary embolism and deep vein thrombosis. American Journal of Respiratory Medicine and Critical Care 2003; (Supplement) Harrington J, McGown A, Hirani, Makker H, Sprio SG, Harrison M, Newman S. The Association between O2 desaturation dip rate in obstructive sleep apnoea and neuropsychological function.European Sleep Society August, 2003. McGown AD, Makker HK, Stygall J, Harrington J, Smith C, Luo YM, Melehan K, Newman S, Sprio SG. Relationship between polysomnographic measures of sleep fragmentation and hypoxaemia and measures of daytime sleepiness in consecutive patients with obstructive sleep apnoea (OSA) referred to a sleep clinic. Thorax 2003:58:iii7. McGown AD, Harrington J, Stygall J, Makker HK, Hirani SP, Harrison M, Spiro SG, Newman S. Cerebral oxygenation during REM sleep in obstructive sleep apnoea is associated with daytime neuropsychological function. European Respiratory Society September, 2004. Tachtsidis I, Cooper CE, McGown,AD, Makker,H, Delpy DT, Elwell CE. Changes in cerebral total haemoglobin and cytochrome oxidase redox state during sleep apnoeas in patients with obstructive sleep apnoea. 2004 Proc. OSA Biomedical Topical Meeting Singer J, Franklin A, Conway C, Makker H, Waller J, Nikapota A, Warren JP. Sequential Chemotherapy and radiotherapy treatment in locally advanced Non Small Cell Lung Cancer (NSCLC). A phase II study using Carboplatin/ Vinrelbine chemotherapy and four week course of radical radiotherapy. 29th ESMO Congress October 2004. McGown AD, Harrington J, Makker HK, Stygall J, Hirani S, Harrison M, Spiro SG, Newman S. Relationship between REM events rates, REM cerebral oxygenation and CPAP compliance in consecutive subjects with obstructive sleep apnoea. Thorax 2004 Supplement. Makker H, Kosmin J, Chairman D. Does ethnicity affect survival of lung cancer patients in the United Kingdom? Lung Cancer 2006:52;Supplement 2;S25. Oral presentation at 10th Central European Lung Cancer Conference, Prague, Czech Republic, June 2006. Navani N, Makker H, Kocjan G, Pereira SP, Griffith J, Spiro SG, Janes SM. The sensitivity, negative predictive value and accuracy of a new endobronchial ultrasound service. Thorax 2008;63 (Suppl VII) A69;S159. Davda R, Griffith JSG, Smith D, Makker H, Read GA, Ward D, Sundaresan V, Falzon M, Singer JM. Sequential chemoradiation and radiation alone in the treatment of inoperable, locally advanced Non Small Cell Lung Cancer (NSCLC) and the effect of tumour ERCC1 expression on survival. Lung cancer 2009; Volume 64:Supplement1;S46. Presented at European Multidisciplinary Conference in Thoracic Oncology (ECMTO) 2009. Makker H, Ariyratne H. Breathlessness on bending down in COPD patients – prevalence and predictors. European Respiratory Journal 2009. European Respiratory Society 2009 Oct, Vienna.

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Books Case History in Lung Cancer; Himender Makker, Adam Ainley, Sanjay Popat, Julian Singer, Martin Hayward and Antke Hagena, Oxford University Press ( November, 2018) Perioperative Management of Obstructive Sleep Apnoea: Editor -Vladimir Macavei Himender Makker - Co-Author Lambert Academic Publishing June 2017

Case histories in Sleep Medicine Himender Makker, Matthew Walker, Hugh Selsick, Bhik Kotecha, and Ama Johal: Oxford University Press. Published March 2015 Book Chapters Makker HK. Epidemiology of Obstructive Sleep Apnoea In: Manual on TB, HIV and Lung Health” 2009; 516-533. Editor Professor VK Arora Makker HK. Light induced Fluorescence Endoscopy (LIFE)-System and constraints. In: Practical Approach to Critical Respiratory Medicine” 2006; 517-521 Editor Professor VK Arora Makker HK. Management of Obstructive Sleep Apnoea In: Practical Approach to Critical Respiratory Medicine. 2006; 614-620 Editor Professor VK Arora Makker HK, Holgate ST. Immune Response in Human Pathology: Hypersensitivity In; A Textbook of Immunopharmacology Editors: Professor Nijkamp & Dr Parnham 1997 Makker HK, Holgate ST. Pathophysiology: Role of Mediators in Exercise-induced asthma. Allergic and Respiratory disease in Sports Medicine, 1994 Editor Professor JM Weiler Beasley R, Makker HK, Holgate ST A critique of single mediator based interventions: Alternative approach to future therapy In; Lipid mediators in Allergic Disease of the Respiratory Tract. Editor C Robinson, 1993

Reviews Brown J, Makker H. Review Excessive daytime sleepiness Commissioned by British Medical Journal 2018 (in preparation) Faber s, Makker H An approach to management of hypercapnic respiratory failure Foundation Training Journal Nov 2018 McDermott R, Makker R Key Questions in sleep apnoea Pulse Learning Respiratory Medicine 2017

Jaydev A, Law S, Makker HK. Early Diagnosis of Obstructive Sleep Apnoea Foundation Year Journal 2015; Volume 9, Issue 4; 20-26. Ainley A, Makker HK. The impact of Obstructive Sleep Apnoea in Pregnancy Foundation Year Journal. 2015; Volume 9, Issue 4; 42-48. Mangera Z, Panesar G, Makker H. Practical approach to management of respiratory complications in neurological disorders. Int J Gen Med. 2012; 5:255-63. Panesar K, Pfeffer P, Makker H. Invasive and Non-Invasive Ventilation-Good Clinical Care.

PUBLICATIONS

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Foundation Year Journal. October 2011(5):39-43 Dharama R, Zammit C, Makker H. Prevalence and Predictors of Sleep Apnoea International Journal of Respiratory Care 2011:19-22 Zammit C, Liddicoat H, Moonsie I, Makker H. Obesity and respiratory diseases. Int J Gen Med. 2010; 3:335-43 Liddicoat H, Zammit C, Makker H. Driving and Sleep Apnoea International Journal of Respiratory Care 2010:23-26. Simcock D, Makker HK. Management of Obstructive sleep apnoea. Foundation Year Journal 2009; 3; 40-45. Astin R, Makker HK. Case based discussion Haemoptysis. Foundation Year Journal 2009; 17-21. Makker HK, Holgate ST. Mechanisms of Exercise-Induced Asthma. Eur J Clin Invest: 1994; 24:1402-1408. Makker HK, Montefort, Holgate ST. Investigative use of fibre-optic bronchoscopy in asthma for local airway challenge. Eur Respir J 1993; 6:1402-1408. Original Papers and Case Reports Spurling KJ, Perks JL, Makker HK. Misleading sleep-diagnostic results in a patient with variable nasal airflow obstruction. Sleep Science (2015), doi:10.1016/j.slsci.2015.05.001. Navani N, Nankivell M, Lawrence DR, Lock S, Makker H, Baldwin DR, Stephens RJ, Parmar MK, Spiro SG, Morris S, Janes SM; Lung-BOOST trial investigators. Lung cancer diagnosis and staging with endobronchial ultrasound-guided transbronchial needle aspiration compared with conventional approaches: an open-label, pragmatic, randomised controlled trial. Lancet Respir Med. 2015 Apr;3(4):282-9. Macavei VM, Spurling KJ, Loft J, Makker HK. Diagnostic predictors of obesity-hypoventilation syndrome in patients suspected of having sleep disordered breathing. J Clin Sleep Med. 2013 Sep;9(9):879-84. Spurling KJ, Makker HK. Reliability of patient self-assessment for Modified Mallampati Score. J Clin Sleep Med. 2010 15; 6(2):207. Makker HK, Brown JP, Borgstein R, Hayward M, Griffith JS. Under pressure. Lancet. 2008 Aug 30; 372:776. Tachtsidis I, Cooper CE, McGown AD, Makker H, Delpy D.T, Elwell C.E. Changes in cerebral total haemoglobin volume and cytochrome oxidase redox state during deep apnoeas in patients with obstructive sleep apnoea. Biomedical Optics 2006 Technical Digest McGown AD, Makker H, Elwell C, Al Rawi PG, Valipour A, Spiro SG. Measurement of changes in cytochrome oxidase redox state during obstructive sleep apnea using near-infrared spectroscopy. Sleep. 2003 Sep; 26(6):710-6. Valipour A, McGown AD, Makker H, O'Sullivan C, Spiro SG. Some factors affecting cerebral tissue saturation during obstructive sleep apnoea. Eur Respir J. 2002 Aug; 20(2):444-50.

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Valipour A, Makker HK, Hardy R, Emegbo S, Toma T, Spiro SG. Symptomatic gastroesophageal reflux in subjects with a breathing sleep disorder. Chest. 2002; 121(6):1748-53. Kothari P, Aly HS, Makker HK. A solitary pulmonary cystic mass resulting from hydatid disease mimicking a pericardial cyst. Hosp Med. 2001 Oct; 62(10):640-1 McGown AD, Makker HK, Battagel JM, L'Estrange PR, Grant HR, Spiro SG. Long-term use of mandibular advancement splints for snoring and obstructive sleep apnoea: a questionnaire survey. Eur Respir J. 2001 Mar; 17(3):462-6. Makker HK, Ayres JG. Work-related asthma in an aircraft engine mechanic. Respir Med. 1999 Jan; 93(1):69-70. Wales D, Makker H, Kane J, McDowell P, O'Driscoll BR. Systemic bioavailability and potency of high-dose inhaled corticosteroids: a comparison of four inhaler devices and three drugs in healthy adult volunteers. Chest. 1999 May; 115(5):1278-84. Makker HK, Springall DR, Redington AE, Ghatei MA, Bloom SR, Polak JM, Howarth PH, Holgate ST. Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge. Clin Exp Allergy. 1999 Feb;29(2):241-7. Rajakulasingam K, Makker HK, Howarth PH, Holgate ST. Cross refractoriness between bradykinin and hypertonic saline challenges in asthma. J Allergy Clin Immunol. 1995 Oct;96(4):502-9. Makker HK, Chisholm R, Rate AJ, Bancewicz J, Bernstein A. Dysphagia due to secondary achalasia as an early manifestation of squamous cell carcinoma. Postgrad Med J. 1995 Aug;71(838):502-4. Makker H, Kishen R, O'Driscoll R. Atropine as premedication for bronchoscopy. Lancet. 1995 Mar 18; 345(8951):724-5. Makker HK, Walls AF, Goulding D, Montefort S, Varley JJ, Carroll M, Howarth PH, Holgate ST. Airway effects of local challenge with hypertonic saline in exercise-induced asthma. Am J Respir Crit Care Med. 1994 Apr;149(4 Pt 1):1012-9. Makker HK, Holgate ST. The contribution of neurogenic reflexes to hypertonic saline-induced bronchoconstriction in asthma. J Allergy Clin Immunol. 1993Jul; 92(1 Pt 1):82-8. Makker HK, Lau LC, Thomson HW, Binks SM, Holgate ST. The protective effect of inhaled leukotriene D4 receptor antagonist ICI 204,219 against exercise-induced asthma. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1413-8. Makker HK, Holgate ST. Relation of the hypertonic saline responsiveness of the airways to exercise induced asthma symptom severity and to histamine or methacholine reactivity. Thorax. 1993 Feb; 48(2):142-7. Makker HK, Barnes PC. Fatal haemoptysis from the pulmonary artery as a late complication of pulmonary irradiation. Thorax. 1991 Aug;46(8):609-10. Capewell S, Ali NJ, Makker H, Cockwell P, Davies DP, Rogers S, Gray M,Gillies A. Radial artery puncture: a comparison of three haemostatic techniques. Respir Med. 1990 Nov; 84:495-7. Makker H, McConnochie K, Gibbs AR. Post irradiation pulmonary fibrosis complicated by aspergilloma and bronchocentric granulomatosis. Thorax. 1989Aug; 44(8):676-7.