8/8/2019 HIV_AIDS, Allergies, Autoimmunity

1/6

&KDSWHU,QWHUYHQWLRQVIRU&OLHQWVZLWK+,9$,'6DQG2WKHU,PPXQRGHILFLHQFLHV

'LVHDVHRI7O\PSKRF\WHYLUXVDWWDFKHVWRWFHOOOLQLQJRIWO\PSKFHOODQGJHWLQWRWO\PSK

DQGJURZZLWKLQLWDWWDFKLQJLQQXFOHXVXVLQJPDWHULDODQGJURZVDQGUHSOLFDWHVPRYLQJRXW

RIWO\PSKDQGVSUHDG6SHFLILF&'O\PSK+HOSHU

+,9FODVVLILFDWLRQVLQFOXGH$SHUVRQLQFOLQLFDOFDWHJRU\$LV+,9SRVLWLYH

$SHUVRQLQFOLQLFDOFDWHJRU\%LVLQIHFWHGZLWK+,9

$SHUVRQLQFOLQLFDOFDWHJRU\&KDV$,'6PHDQLQJWKH\DUH+,9DVZHOO

1RUPDOKHDOWK\&'7O\PSKRF\WHVFDQILQGYLUXVHWFEXWLIWKH&'7

O\PSKLVLQQRUPDOUDQJH\RXUILQHVWLOOKDYH+,9EXWRNEXWLILWIDOOVWRRUOHVVSWKDV

PRYHGLQWRFDWHJRU\RI$,'6QRFXUHIRU+,9$,'6

0HDVXUHYLUDOORDG&'FRXQWVDVWKHYLUXVJURZVDQGUHSOLFDWHVWKH&'IDOOV

9LUXVVSUHDGVWKURXJKGLIIHUHQWURXWHVFROGGURSOHW+,9KLJKHULQFLGHQWLQVHPHQEORRG

HWFEUHDVWPLONVH[HWFFRQWDFWZLQIHFWHGERG\IOXLGV

+HDOWK3URPRWLRQDQG,OOQHVV3UHYHQWLRQ

(GXFDWLRQLVWKHEHVWKRSHIRUSUHYHQWLRQ+,9LVWUDQVPLWWHGPRVWRIWHQLQWKUHHZD\V6H[XDO

$%&V$EVWLQHQFH%(&$5()8/%(0RQRJDPRXV:HDU&RQGRPV 0RUHOLNHO\IRUPDOHWRLQIHFWIHPDOHWKDQYLFHYHUVD $QDOLQWHUFRXUVHKDVKLJKSUREDELOLW\RIVSUHDGQRPDWWHUZKRKDVLW /DWH[FRQGRPVKHOSVSUHYHQWVSUHDGRIGLVHDVHLIRQHLVHQJDJLQJRXWVLGH

PRQRJDPRXVUHODWLRQVKLS

0D\QHYHUFRQYHUWIURP+,9WR$,'63DUHQWHUDO

%ORRGQHHGOHVDQGV\ULQJHVQHHGOHH[FKDQJHSURJUDPWRGHFUHDVHVSUHDGRIGLVHDVH:$7(5+286(+2/'%/($&+WHDFKGUXJXVHUWRFOHDQHTXLSPHQW

,QGLYLGXDOFRXOGKDYHVH[ZLWKXQNQRZQ+,9SHUVRQDQGWKHQJHWVFKHFNEXWWKHUHLVQRHYLGHQFH/$*7,0(QRWHQRXJKWLPHVLQFHH[SRVXUHMXVWGRQWKDYHSRVLWLYH

DQWLERG\\HWVRRRZHPD\EHJLYLQJEORRGDQGZKHQWKH\FKHFNHGLWZDV

QHJDWLYHLQZNVLWPD\EHILQH

)DVWHU+,9SURJUHVVLQJWR$,'6FRPSDUHGWRVH[XDO3HULQDWDOFKDQFHWKDWLQIHFWHGPRPZLOOWUDQVPLWLWWRXQERUQIHWXV &DQORZHUFKDQFHE\JLYLQJPHGV 6KRXOGQWEUHDVWIHHGEDE\

4XHVWLRQ:KLFKJURXSKDVKLJKHVWSHUFHQWDJHRI$,'6FDVHVLQ1RUWK$PHULFD"

0HQRUZRPHQZKRXVHLQMHFWLRQGUXJV 1HZERUQRIPRWKHUVZKRDUH+,9SRVLWLYH

8/8/2019 HIV_AIDS, Allergies, Autoimmunity

2/6

0HQZLWKRWKHUPHQ :RPHQZLWKZRPHQ$QVZHU$

7UDQVPLVVLRQDQG+HDOWK&DUH:RUNHUV

6WDQGDUG3UHFDXWLRQVVXIILFLHQW*ORYHVLQWRFRQWDFWZLWKPXFRXVPHPEUDQHVEORRGYDJRUVHPHQVHFUHWLRQV

$OOFOLHQWVZLWKRUZRXW+,9ZHDVVXPHDOOSWDUH+,9EHFDXVHZHGRQRWNQRZWKHLUVWDWXV

3UHYHQWLRQRI1HHGOHVWLFNRUVKDUSVLQMXULHVQHHGOHVVV\VWHPHWF 3UHYHQWLRQRIH[SRVXUHWKURXJKQRQLQWDFWVNLQRUPXFRXVPHPEUDQHV ,IVWXFNZDVKZDVKZDVKUHSRUWWRVXSHUYLVRUDQGHPSOR\HHKHDOWKVXUYHLOODQFH

&ROODERUDWLYH0DQDJHPHQW

+LVWRU\ULVN\EHKDYLRUVNQRZQ+,9VWDWXV ,IWKH\KDYHYLUXVWKH\DUHLPPXQRVXSSUHVVHG 3K\VLFDODVVHVVPHQWDQGFOLQLFDOPDQLIHVWDWLRQV ,QIHFWLRQVRSSRUWXQLVWLFZRQWHIIHFWSHUVRQZLWKJRRGLPPXQH

IXQFWLRQVSHFLILFW\SHRISQHXPRQLDZLWK3QHXPRF\VWLVFDULQLL

7R[RSODVPDJRQGLLSURWR]RDOIXQJDOEDFWHULDOYLUDO6(9(5(

GLDUUKHDORVLQJOLWHUVGD\

7KHVHDUHZRUVHWKDQQRUPDOSQHXPRQLDRURWKHULQIHFWLRQV &DQGLGLWLVHWF 0DOLJQDQFLHV.DSRVLVVDUFRPDPDOLJQDQWO\PSKRPDVKLJKHU

ULVNIRUWKHVH

.DSRVLVDUFRPD1RGXOHVLQVNLQPRXWKORRNVOLNHEORRGEOLVWHUV

(QGRFULQHFRPSOLFDWLRQVJRQDGDODGUHQDOSDQFUHDWLF *RQDGDOVXSSUHVVLRQGHFUHDVHLQQRUPDO

KRUPRQHVGHFUHDVHVSHUPFRXQWLUUHJXODU

SHULRGHWF

$GUHQDOH[FHVV&XVKLQJRUGHI$GGLVRQV 3DQFUHDWLFGLDEHWHVSDQFUHDWLWLV4XHVWLRQ5HYLHZLQJFKDUWRISWZLWK$,'6QXUVHUHFDOOVPRVWRSSRUWXQLVWLFLQIHFWLRQZLWK

+,97%FDXVHGE\P\FREDFWHULXPWXEHUFXORVLV3-33QHXPRF\VWLVMLURYHQFLSQHXPRQLD&09&\WRPHJDORYLUXVFDXVLQJ&09UHWLQLWLV7R[RSODVPRVLVHQFHSKDOLWLVFDXVHGE\7R[RSODVPDJRQGLL$QVZHU%

2WKHU&OLQLFDO0DQLIHVWDWLRQV

8/8/2019 HIV_AIDS, Allergies, Autoimmunity

3/6

$,'6GHPHQWLDFRPSOH[ 1HXURORJLFGLPLQLVKLQJ :DVWLQJV\QGURPH 6HYHUHPDOQXWULWLRQZLWK$,'6/RVVRIIDWDQGPXVFOHPDVV 1RHQHUJ\EHGULGGHQ 6NLQFKDQJHV 1R:%&WRKHDOEURNHQDUHD4XHVWLRQ3WIHDUIXOWKDWKHEHHQLQIHFWHGZLWK+,91XUVHUHFRJQL]HVWKDWVWPDQLIHVWDWLRQ

RI+,9LQIHFWLRQLV

2SSRUWXQLVWLFLQIHFWLRQ )HYHUQLJKWVZHDWDQGPXVFOHDFKH /\PSKRF\WRSHQLDGHFUHDVHO\PSKRF\WHFRXQW 5HGXFHGQXPEHUVRI&'7&HOOV$QVZHU%IOXOLNH

/DERUDWRU\$VVHVVPHQW /\PSKRF\WHFRXQWVORZ &'&'FRXQWVORZ /\PSKRF\WHFRXQWORZLVDFOXHWRORRNIXUWKHUDQGWKHQORRNDWWKH&'YDOXHV $QWLERG\WHVWV (Q]\PHOLQNHGLPPXQRVRUEHQWDVVD\(/,6$ 5$3,'EORRGWHVW1RWUHDODFFXUDWHFKHDS :HVWHUQEORWYLUDOFXOWXUHYLUDOORDG :HVWHUQEORWH[SHQVLYHWDNHVWLPHEXWPRUHDFFXUDWH 9LUDOORDGVRLWVQRWHYHQGHWHFWDEOH

'UXJ7KHUDS\

0HGVZLWKDQWLUHWURYLUDOHIIHFWVRQO\LQKLELWYLUDOUHSOLFDWLRQEXWGRQRWNLOOWKHYLUXV

1XFOHRVLGHDQDORJUHYHUVHWUDQVFULSWDVHLQKLELWRUVORRNOLNHWKHYLUXVEXWSUHYHQWLWIURPUHSOLFDWLQJLWVHOI5HWURYLUo9LGH[o

1RQQXFOHRVLGHDQDORJUHYHUVHWUDQVFULSWDVHLQKLELWRUV 3URWHDVHLQKLELWRUV1RUYLUo&UL[LYDQo,QYLUDVHo.DOHWUDo3HQWDPSJ )XVLRQLQKLELWRUV ,PPXQHHQKDQFHPHQW4XHVWLRQ:KHQWHDFKLQJSWDERXW$,'6GUXJWKHUDS\QXUVHHPSKDVL]HVWKDWGUXJPXVWEHWDNHQH[DFWO\DVSUHVFULEHVZRXWPLVVLQJGRVHV7KHUHDVRQIRULV

0LVVHGGRVHVFDQSURPRWHGUXJUHVLVWDQFHORZHULQJHIIHFWLYHQHVVRIGUXJV 0LVVHGGRVHVDOORZGHYRIRSS,QIHFWLRQ $QLQFUHDVHGFKDQFHRIDOOHUJLFU[WKHGUXJPD\RFFXU 9LUDOUHSOLFDWLRQGHFUHDVHVZKHQGRVHVDUHPLVVHG$QVZHU$

8/8/2019 HIV_AIDS, Allergies, Autoimmunity

4/6

1XWULWLRQ5HODWHG'HILFLHQFLHV

*RRGQXWULWLRQQHHGHGIRUSURSHULPPXQHIXQFWLRQ 0DOQXWULWLRQDPDMRUFDXVHRIJOREDOLPPXQRGHILFLHQF\ 3URWHLQFDORULHPDOQXWULWLRQ ,QFUHDVHGLQFLGHQFHDQGVHYHULW\RILQIHFWLRXVGLVHDVHLQREHVLW\1XWULWLRQVXSSRUWHPRWLRQDOVXSSRUWHWF

,PPXQRGHILFLHQFLHV

3ULPDU\FRQJHQLWDO 7KHUDS\LQGXFHGVHFRQGDU\LPPXQRGHILFLHQFLHV 'UXJLQGXFHGLPPXQRGHILFLHQFLHV&\WRWR[LFGUXJV

&RUWLFRVWHURLGV

&\FORVSRULQH 5DGLDWLRQLQGXFHGLPPXQRGHILFLHQFLHV&KDSWHU,QWHUYHQWLRQVIRU&OLHQWVZLWK,PPXQH)XQFWLRQ([FHVV+\SHUVHQVLWLYLW\

$OOHUJ\DQG$XWRLPPXQLW\

+\SHUVHQVLWLYLWLHV$OOHUJLHV

,QFUHDVHGRUH[FHVVLYHUHVSRQVHWRWKHSUHVHQFHRIDQDQWLJHQWRZKLFKWKHFOLHQWKDVEHHQH[SRVHG

5HDFWLRQXQFRPIRUWDEOHOLIHWKUHDWHQLQJ +\SHUVHQVLWLYLW\DOOHUJ\7\SH,5DSLG+\SHUVHQVLWLYLW\5HDFWLRQV

$WRSLFDOOHUJ\PRVWFRPPRQ2FFXUVZLWKLQPLQXWHVWRKRXUVRIDQWLJHQH[SRVXUH'HYHORSPHQWRI,J(DQWLERGLHVLQUHVSRQVHWRWKHW\SLFDOKDUPOHVVHQYLURQPHQWDQWLJHQV5HOHDVHRIYDVRDFWLYHDPLQHVKLVWDPLQHVDQGRWKHULQIODPPDWRU\PHGLDWRUVWKLVFDXVHV

YDVRGLODWLRQDQGLQFUHDVHYDVFXODUSHUPHDELOLW\UHVXOWLQJLQHGHPDVPRRWKPXVFOH

FRQWUDFWLRQLQDUWHULDODQGDUWHULROHZDOOVYDVRFRQVWULFWLRQ

&RQWDFWHGE\

,QKDOHG

,QJHVWHG

/RFDOL]HGUHDFWLRQV(J$VWKPD

)RRGRULQJHVWHGDOOHUJHQVSULPDULO\DIIHFWWKHJDVWURLQWHVWLQDOWUDFW

6\VWHPLFUHDFWLRQV $QDSK\OD[LVZLWKVNLQWHVWLQJDOOHUJLHV

&ROODERUDWLYH0DQDJHPHQW

8/8/2019 HIV_AIDS, Allergies, Autoimmunity

5/6

+LVWRU\ 3K\VLFDODVVHVVPHQWFOLQLFDOPDQLIHVWDWLRQV /DERUDWRU\DVVHVVPHQW $OOHUJ\WHVWLQJLQWUDGHUPDOWHVWLQJRUDOIRRGFKDOOHQJH $YRLGDQFHWKHUDS\V\PSWRPDWLFWKHUDS\GUXJWKHUDS\ 'UXJWKHUDS\'HFRQJHVWDQW$QWLKLVWDPLQHV&RUWLFRVWHURLGV 'HVHQVLWL]DWLRQWKHUDS\

$QDSK\OD[LV

)LUVWXQHDVLQHVVDSSUHKHQVLRQZHDNQHVVDQGLPSHQGLQJGRRP 3UXULWXVDQGXUWLFDULD (U\WKHPDDQGVRPHWLPHVDQJLRHGHPDRIWKHH\HVOLSVRUWRQJXH +LVWDPLQHFDXVHVFDSLOODU\OHDNEURQFKRFRQVWULFWLRQPXFRVDOHGHPDDQGH[FHVVPXFXV

VHFUHWLRQ

6WULGRUZKHH]LQJ &RQJHVWLRQUKLQRUUKHDG\VSQHDDQGLQFUHDVLQJUHVSLUDWRU\GLVWUHVVZLWKDXGLEOHZKHH]LQJUHVXOW

$QDSK\OD[LVFDQEHIDWDO4XHVWLRQ&KHPUHVSRQVLEOHIRUFDSOHDN+,67$0,1(

,QWHUYHQWLRQV$%&

)LUVWDVVHVVUHVSLUDWRU\IXQFWLRQDQDLUZD\PXVWEHHVWDEOLVKHG &35PD\EHQHHGHG (SLQHSKULQHLVJLYHQDVVRRQDVV\PSWRPVDSSHDU(SL3HQLIKDVVHYHUHDOOHUJ\1HHG

PHGDOHUWEUDFHOHW

6ROXWLRQLVGRVHLVPOPOPJP/64 $QWLKLVWDPLQHVWUHDWDQJLRHGHPDDQGXUWLFDULD,9 2[\JHQUHGXFHVK\SR[HPLD7\SH,9'HOD\HG+\SHUVHQVLWLYLW\5HDFWLRQV

,QDW\SH,9UHDFWLRQWKHUHDFWLYHFHOOLVWKH7O\PSKRF\WH7FHOO $QWLERGLHVDQGFRPSOHPHQWDUHQRWLQYROYHG /RFDOFROOHFWLRQRIO\PSKRF\WHVDQGPDFURSKDJHVFDXVHVHGHPDLQGXUDWLRQLVFKHPLD

DQGWLVVXHGDPDJHDWWKHVLWH

([DPSOHVLQFOXGHSRVLWLYHSXULILHGSURWHLQGHULYDWLYHDQWLJHQ33'FRQWDFWGHUPDWLWLVSRLVRQLY\VNLQUDVKHVLQVHFWVWLQJVWLVVXHWUDQVSODQWUHMHFWLRQDQGVDUFRLGRVLV

6RPHRQHZKRLVLPPXQRVXSSUHVVLYHPD\QRWKDYHHQRXJKQHXWURSKLOVWRVWLPXODWH

UHDFWLRQHWF

6DUFRLGFDXVHVVFDUWLVVXH6FDUWLVVXHLQOXQJVSXOPRQDU\QRW[

4XHVWLRQ7\SHRIWUDQVIXVLRQU[ZRXOGSWZKRUHFHLYHGPXOWLSOHWUDQVIXVLRQGXULQJFDQFHUW[

PRVWOLNHO\H[SHULHQFH")HEULOHPRVWRIWHQLQSWZLWKDQWL:%&DQWLERG\VLWXDWLRQWKDWGHY

DIWHUPXOWLSOHWUDQVIXVLRQ%DFWHULDOU[RFFXUDVUHVXOWRILQIXVLQFRQWDPLQDWHGEORRG

8/8/2019 HIV_AIDS, Allergies, Autoimmunity

6/6

SURGXFWV$OOHUJLFU[DUHPRVWRIWHQVHHQLQSWZLWKK[RIDOOHUJ\+HPRO\WLFU[DUHFDXVH5K

LQFRPSDW

%DFWHULDO

$OOHUJLF

+HPRO\WLF

4XHVWLRQ:RPHQRIZKLFKHWKLFDOJURXSDUHPRVWIUHTDIIHFWHGE\DXWRLPPXQHGLVHDVH"

$$

$VLDQ

:KLWH

+LVSDQLFV

$XWRLPPXQLW\

$QLQDSSURSULDWHLPPXQHUHVSRQVHZLWKIDLOXUHWRUHFRJQL]HFHUWDLQERG\FHOOVRUWLVVXHVDVVHOIDQGWULJJHUVLPPXQHUHDFWLRQV

$QWLERGLHVDQGRUO\PSKRF\WHVDUHGLUHFWHGDJDLQVWKHDOWK\QRUPDOFHOOVDQGWLVVXHV 7UHDWPHQW ([DPSOHVRI$XWRLPPXQH'LVRUGHUV 6\VWHPLF/XSXV(U\WKHPDWRXV6/( 5KHXPDWRLG$UWKULWLV +DVKLPRWRVWK\URLGLWLVZRPHQLQZRPHQLQIODPHRIWK\URLGUHVXOWLQJLQK\SRWK\URLGLVP

6\QWKURLGWK\URLGKRUPRQH3WZRQWJDLQZWEORRGSUHVVXUHDQGKHDUWUDWHQRUPDO

ERG\WHPSILQH*UHDWHUULVNIRUO\PSKRPDVHWF5(&$//7+