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Honors Biology Chapter 7 Beyond Mendelian Genetics Slide 2 Many Human Phenotypes Follow Mendelian Pattern One gene / two alleles = 1 trait Slide 3 Genetic Disorders Rare heritable illnesses Most lethal disorders are recessive Slide 4 Cystic Fibrosis Slide 5 Huntingtons Disease Dominant Slide 6 Some Deleterious Genes Are Sex-Linked X-linked Recessive Hemophilia (Bleeders Disease) Slide 7 Hemophilia Slide 8 Slide 9 X-linked Dominant Retinitis Pigmentosa Slide 10 Non-Mendelian Genetics Complex Patterns of Inheritence Traits do not segregate according to Mendels Laws X inactivation Incomplete Dominance Codominance Polygenic Traits Epistasis Multiple Alleles Environmental Influences Others Slide 11 X-Inactivation Slide 12 Slide 13 Epistasis Slide 14 Incomplete Dominance Slide 15 Codominance Slide 16 Slide 17 Multiple Alelles Slide 18 Sex-linked Traits Slide 19 Slide 20 Slide 21 Polygenic Traits Slide 22 Slide 23 Slide 24 Slide 25 Gene Linkage Slide 26 Karyotypes Prepared from blood, bone marrow, amniotic fluid, placenta Slide 27 Karyotypes Slide 28 Karyotypes Detect Abnormal # Slide 29 Karyotypes Detect Structural Defects Slide 30 Pedigrees