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HOST OFFERS FROM THE JAGIELLONIAN UNIVERSITY IN KRAKÓW FOR MARIE SKŁODOWSKA - CURIE INDIVIDUAL FELLOWSHIPS
IN HORIZON 2020
Marie Skłodowska – Curie Action
Individual Fellowships 2019
MSCA INDIVIDUAL FELLOWSHIP
The goal of the MSCA Individual Fellowships is to enhance the creative and innovative potential of experienced researchers, wishing to diversify their individual competence in terms of skill acquisition through advanced training, international and intersectoral mobility.
Individual Fellowships provide opportunities to researchers of any nationality to acquire and transfer new knowledge and to work on research and innovation in Europe (EU Member States and Horizon 2020 Associated Countries) and beyond. The scheme particularly supports the return and (re)integration of European researchers from outside Europe and those who have previously worked here, as well as researchers displaced by conflict outside the EU and Horizon 2020 Associated Countries. It also promotes the career restart of individual researchers who show great potential.
The MSCA Individual Fellowships are available for experienced researchers of any nationality, who must have, at the date of the call deadline, a doctoral degree or at least four years of full time equivalent research experience.
Eligible candidates must comply with MSCA mobility rules:
For European Fellowships (including Career Restart, Reintegration, Society and Enterprise, and Standard European Fellowships): the researcher cannot have resided or carried out his/her main activity (work, studies, etc.) in the country of the beneficiary for more than 12 months in the three years immediately before the call deadline.
For Global Fellowships (include a research period in a Third Country, followed by a reintegration period at the Host Institution): the researcher cannot have resided or carried out his/her main activity (work, studies, etc.) in the Third Country where the outgoing phase takes place for more than 12 months in the three years immediately before the call deadline.
The grant provides an allowance to cover your living, mobility and family costs. The grant is awarded to your host organisation. The research costs and overheads of the host organisation are also supported.
Opening: 11 April 2019 r.
Deadline: 11 September 2019 r. (17.00 Brussels local time)
HOW TO APPLY:
In response to this invitation, please:
check the list of priority fields and supervisors in the attached call for proposals
contact the selected scientist to determine the principles and possibilities of cooperation
prepare your CV and research proposal together with your supervisor
enjoy the grant and implement the project at the Jagiellonian University in Krakow.
More information about the rules of project implementation at the Jagiellonian University in Krakow can be found on the website of the Centre for Project Administrative Support at the Jagiellonian University in Krakow: https://cawp.uj.edu.pl/en_GB/projekty/dla-wnioskujacych
In case of doubt, please write to: [email protected]
FOR MORE DETAILS, PLEASE VISIT:
MSCA Website
Funding & Tender Opportunities
MSCA Work Programme
Guide for applicants IF-2019
Standard proposal template
JAGIELLONIAN UNIVERSITY IN KRAKÓW
The Jagiellonian University is the oldest higher education institution in Poland and one of the oldest in Europe. It was founded on 12 May 1364 by the Polish king Casimir the Great.
Since its very beginning, the Jagiellonian University has been an international institution. Poles, Ruthenians, Lithuanians, Hungarians, Germans, Czechs, the Swiss, the English, the Dutch, the French the Spanish, Italians, and even Tatars studied here in the old days.
Some of the Jagiellonian University students and academics have been major historical figures, including world famous scholars, such as Nicolaus Copernicus, Karol Olszewski, Bronisław Malinowski, Wisława Szymborska – Nobel Prize winner in literature in 1996, as well as Karol Wojtyła, the future Pope John Paul II.
Today, the Jagiellonian University comprises 16 Faculties, where nearly 4 thousand academic staff conduct research and provide education to over 40 thousand students, within the framework of more than 80 different fields of study. The eminent researchers and state-of-the-art infrastructure make the Jagiellonian University one of the leading Polish scientific institutions, collaborating with major academic centres from all over the world. The Jagiellonian University is also home to about 150 student societies, where young researchers pursue their academic interests and develop friendships with people who share their passion.
The University was recognized by the international databases Web of Science and Elsevier Scopus as possessing the most prolific researchers in Poland, publishing the most academic papers. In 2018, it was the only Polish and Eastern European higher education institution in Reuter’s Top 100: Europe’s Most Innovative Universities ranking.
The most unique large-scale projects run by the Jagiellonian University include the Jagiellonian Centre for Experimental Therapeutics, Małopolska Centre for Biotechnology, Centre for Medical Genomics OMICRON, and National Synchrotron Radiation Centre SOLARIS.
Yet another advantage of the Jagiellonian University is its location in the historic city of Kraków, the former capital of Poland and a great cultural centre, visited by millions of tourists. Some of the University buildings are major historical sites themselves.
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PROPOSALS FOR FOREIGN RESEARCHERS
FACULTY OF BIOLOGY
Study programmes at the Faculty of Biology are very flexible in nature. Students can learn about cells, organisms, and environments. The academic offer includes Biology and Neurobiology. The faculty is composed of 3 institutes: the Institute of Botany, the Institute of Environmental Sciences, and the Institute of Zoology and Biomedical Research as well as the Botanical Garden.
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Supervisor: dr hab. Ulf Bauchinger
Contact:
Main research field:
Integrative and organismal biology: animal energetics, aerobic performance, oxidative stress, senescence.
Significant achievements:
Scientific contributions on maintenance physiology and its effects on whole animal performance. Formulated the tissue turnover hypothesis to explain organ mass changes in the context of fasting and migration. Publications on diverse animal models and also research topics in various fields from animal behaviour, morphology, physiology, to molecular biology, ecology and evolutionary biology.
Preferred main research goals for candidate:
Dependent on candidate: either
1. Significantly contribute to ongoing research with the goal to justify co-authorship of a research publication.
2. Run a scientific experiment and take lead in manuscript writing as lead author.
Research environment: e.g. Physiological Ecology Team linked to national and international research partners, strong expertise on metabolic rate measurements in arthropods, snakes, birds, and mammals. Field and/or laboratory studies.
Supervisor: dr Piotr Łukasik
Contact: [email protected]
Main research field: Biology: Evolution, Biodiversity, Entomology, Microbiology, Bioinformatics.
Significant achievements:
The Symbiosis Evolution research group starts in July 2019, supported by about 1.7M EUR across three competitive research grants secured within the last year. The Principal Investigator has recently published in journals such as PNAS, Nature Communications, and Current Biology.
Preferred main research goals for candidate:
The characterization of the diversity, biology and evolution of insect microbiomes using high-throughput next-generation sequencing and bioinformatics.
Research environment:
We are building a dynamic, international, collaborative team within one of the top institutes in the fields of ecology and evolution in Central Europe. Our research, aiming to characterize the diversity and dynamics of insect microbial symbioses, will be conducted in close collaboration with other teams from Poland, Sweden and the U.S.
Supervisor: dr hab. Joanna Rutkowska
Contact: [email protected]
Main research field: Behavioral ecology and evolutionary physiology. I mostly work on a captive colony of zebra finches (Taeniopygia guttata), but can also readily work on other species.
Significant achievements:
1. Demonstration that offspring sex in birds might be adjusted from day to day, in response to the immediate changes in the external environment and hormonal status of the female.
2. Revision of well-established views on gradual shortening of the W chromosome over evolutionary time and egg sexual size dimorphism across avian species using meta-analytical approach.
3. Conceptual and methodological input into the field of maternal effects in birds.
For more information visit: http://iron2.eko.uj.edu.pl/rutkowska/index_e.htm
Preferred main research goals for candidate:
Developing and expanding empirical research on:
1. The effects of environmental variability on physiology, cognitive abilities and fitness in animals.
2. Maternal and paternal effect in animals. Research synthesis of trade-offs in animal performance using systematic review tools and meta-analytical approach.
Research environment:
At the Institute of Environmental Sciences, the laboratories are not assigned to individual research groups. Each research group can obtain access to the laboratory space as needed. This allows efficient use of laboratory space and allows better integration of researchers within the Institute.
My current foreign collaborators include:
Professor Shinichi Nakagawa (University of New South Wales)
Dr. Wolfgang Forstmeier (Max Planck Institute for Ornithology)
Dr. Carlos Botero (Washington University in St. Louis)
Supervisor: dr Izabela Wierzbowska
Contact: [email protected]
Main research field: Population ecology, urban ecology, zoology.
Significant achievements:
Projects on urban carnivore mammals in Europe and participation in similar projects in the USA. Currently, projects on the use of camera traps studies on large mammals in the Gorce Mts, published papers on mammals in natural and urban ecosystems, collaboration with internationals scientists (USA, Kenya, Europe).
Preferred main research goals for candidate:
To learn methods and techniques used in ecology – field and laboratory work including camera traps, tracking, trophic analysis, genetic analysis.
Research environment:
Laboratory for evaluation of trophic analysis together with a collection of reference material, field work equipment including camera traps, GPS receivers, trapping equipment for small and medium sized mammals. Collaboration with business partners, national parks and forest services, national and international scientist and specialists including GIS, statistical modelling.
FACULTY OF BIOCHEMISTY, BIOPHYSICS AND BIOTECHNOLOGY
The faculty offers study programmes in the fields of Biochemistry, Biophysics and Biotechnology. Researchers are concentrated mainly on microbiology, cell biology, immunology, virology, and plant physiology. Although the faculty was established in 2002, it already boasts impressive research results. The academic staff of the faculty actively cooperates with over 80 Polish and foreign research centres.
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Supervisor: dr hab. Dariusz Dziga
Contact: [email protected]
Main research field:
Main specializations: biochemistry and environmental biotechnology.
PhD thesis in the area of biochemistry (enzymology and cell membrane composition).
Plant physiology and biochemistry: enzymatic activity of plant enzymes, composition of xylem sap, photosynthetic activity of aquatic plants, algae and cyanobacteria.
Physiology, biochemistry and genetic of microorganisms: production of toxic secondary metabolites by cyanobacteria, mechanisms of cyanotoxin biodegradation, biochemistry and genetic level of biodegradation.
Interaction of plant with cyanobacteria and bacteria with cyanobacteria on the physiological, biochemical and genetic level.
Genetic engineering of microorganisms, including cloning and heterologous expression, production of recombinant proteins and their purification.
Toxicology of cyanotoxins toward human cells.
Biohydrogen production by microorganisms (nitrogenase activity of purple bacteria, enzymatic hydrolysis of cellulose, transformation of cellulose into biohydrogen).
Methodology: HPLC, LC-MS, ion exchange chromatography, affinity chromatography, gel electrophoresis of proteins and DNA, Western blot, Clark electrode, PAM fluorimeter, genetic engineering (isolation of DNA, restriction enzymes, ligation, transformation, conjugation, recombinant expression).
Significant achievements:
28 publications, including 1 review paper.
33 abstracts in national and international scientific conferences.
Co-author of 3 chapters (including being the first author of the chapter Biological treatment for the destruction of cyanotoxins) in book Water Treatment for Purification from Cyanobacteria and Cyanotoxins, Eds: M.
Antoniou, A. Hiskia, D. D. Dionysiou. John Wiley & Sons Inc; ISBN-10: 111892861X; in press.
Summed Impact Factor of all publications: ~ 66.
Total number of citations, ResearchGate (May 2018): 492.
Hirsch index according to the ResearchGate (February 2018): 11.
Research grants: principal investigator of 5 projects founded by KBN, NCN, CIMO; principal investigator of 3 projects founded by Faculty of Biochemistry, Biophysics and Biotechnology, participation in two other projects.
Reviewer of several manuscripts in 12 different scientific journals.
Preferred main research goals for candidate:
1. Biodegradation of cyanobacterial toxins.
2. Mechanisms of adaptation of toxic and/or invasive cyanobacterial strains to common environmental stress condition.
Research environment:
Team:
The “cyanobacterial team” is a part of Department of Microbiology. It is composed of expert on microbiology, biochemistry, molecular engineering, cell physiology, analytical chemistry. The members of the team are scientists as well as students and PhD students from the Faculty of Biochemistry, Biophysics and Biotechnology.
Infrastructure:
The Faculty occupies a modern "intelligent building" located on the Campus of the 600th Anniversary of the Restoration of the Jagiellonian University, shortly called the Third Campus. Research conducted at the Faculty includes contemporary biochemical, biophysical and biotechnological aspects of biological objects ranging from the molecular level through the cellular and up to the level of whole animal and plant organisms. Many modern experimental and computational methods are used by researchers of the Faculty in standard and specialized laboratories that are well equipped with modern scientific instruments.
International collaboration:
1. Long-term cooperation with Prof. Jussi Meriluoo, Åbo Akademi University, Department of Biochemistry and Pharmacy.
2. Cooperation with group of Prof. Zorica Svircev from University of Novi Sad (Serbia) - investigation of microcystin biodegradation processes in Serbian water bodies.
3. Collaboration with College of Life Science and Technology, Beijing University of Chemical Technology, group of Prof. Pengcheng Fu.
4. Involvement in Cyanocost project (COST ES1105 Action) – participation in official meeting: 3rd MC-WG meeting in Gdansk, Poland. April 2013 and 4th MC-WG meeting in Sofia, Bulgaria. November 2013. Coordination and co-authorship of Handbook „Water Treatment for Purification from Cyanobacteria and Cyanotoxins”. This book has been developed within the frame of the COST-funded CYANOCOST Action.
Supervisor: prof. dr hab. Martyna Elas
Contact: [email protected]
Main research field: Biophysics.
Significant achievements:
1. Elas et al., EPR oxygen images predict tumor control by a 50 percent tumor control radiation dose, Can Res, 2013; Sep 1;73(17):5328-35.
2. Kędracka-Krok et al., Proteomic analysis of proton beam irradiated human melanoma cells, PLOS ONE 2014 Jan 2;9(1):e84621.
3. Krzykawska et al., The role of strong hypoxia in tumors after treatment in the outcome of bacteriochlorin-based photodynamic therapy, Free Rad Biol Med. 2014, 73:239-51.
4. Krzykawska-Serda et a., Correlation Between Hypoxia Proteins and EPR-Detected Hypoxia in Tumors. Adv Exp Med Biol. 2017; 977:319-325.
5. Jasińska-Konior et al., Proton beam irradiation inhibits the migration of melanoma cells, PLOS One, Published: October 10, 2017, 12(10), e0186002.
6. Leszczyński et al., Visualization and Quantitative 3D Analysis of Intraocular Melanoma and Its Vascularization in a Hamster Eye, Int J Mol Sci, 2018, 19 (2), pii: E332.
7. Jasińska-Konior et al., Increased elasticity of melanoma cells after low-LET proton beam due to actin cytoskeleton rearrangements. Sci Rep. 2019 May 7;9(1):7008.
8. Gonet et al., Data processing of 3D and 4D in-vivo electron paramagnetic resonance imaging co-registered with ultrasound. 3D printing as a registration tool. Comput Electr Eng. 2019; 74:130-137.
Preferred main research goals for candidate:
Radiobiology, tumor hypoxia, small animal imaging.
Research environment:
Our Laboratory focuses on small animal imaging, utilizing several methods such as EPR, MRI, ultrasound and CT to non-invasively characterize tumor microenvironment in response to anti-tumor treatments. We work with several experimental models of tumors, both in orthotopic and ectopic locations of breast, melanoma, uveal melanoma, pancreas, lung cancer. We are also interested in radiobiology and mechanisms of tissue response to radiation or modifiers of this response.
Our team consists of 3 post-docs, usually 2-4 PhD students, and Master level students working together. Beside the imaging modalities, we have access to histology, cell culture, molecular biology labs.
We have multiple national and international collaborations, Ophthalmology and Ocular Oncology Clinic in Krakow, Department of Radiation and Cellular Oncology at University of Chicago, Department of Ophthalmology at Leiden University to name just a few.
Supervisor: prof. dr hab. Leszek Fiedor
Contact: [email protected]
Main research field: Primary reactions of photosynthesis, solar energy conversion, photodynamic therapy of cancer.
Significant achievements:
Synthesis of new derivatives of Chl for the use in PDT (patented worldwide).
New model of electronic structure of chlorophylls (Fiedor et al., BBA 1777, 1491–1500, 2008).
Discovery of intrinsic photoprotective mechanisms in chlorophylls (Kotkowiak et al., Angew. Chem. Int. Ed. 56, 10457-10461, 2017).
- discovery of the structural role of side methyl groups in carotenoids (Fiedor et al., J. Phys. Chem. Lett. 7, 1821-1829, 2016, Angew. Chem. Int. Ed. 57, 6501-6506 , 2018).
Preferred main research goals for candidate:
Modifications of photosynthetic pigments, synthesis of new photosensitizers for PDT.
Research environment:
Supervisor’s team consists now of a PhD student, several master students and a technical assistant. The laboratories of the supervisor are equipped in all the facilities required to prepare and carry out investigations on the photosynthetic pigments, from microorganism growing rooms (sterile conditions), to dimmed chemical/biochemical labs and darkrooms.
Major pieces of equipment:
Cary 5000, Cary 400 and Cary 60 spectrophotometers (Varian)
Fluoromax-P spectrofluorometer (Horiba Jobin-Yvon)
Chronos BH time-resolved (10 ps) pulsed spectrofluorometer (ISS)
J-815 spectropolarimeter (JASCO)
ISS High Pressure Cell System
HPLC and FPLC systems
Supervisor: prof. dr hab. Alicja Józkowicz
Contact: [email protected]
Main research field:
My earlier research was focused on angiogenesis and biology of endothelial cells, especially on the role of oxidative stress and heme metabolism in regulation of VEGF- and SDF1-dependent pathways. We found that both these pathways are positively regulated by activation of antioxidant enzyme, heme oxygenase-1 (HO-1), and overactivation (in tumors) or repression (in diabetes) of HO-1 leads to disturbed angiogenesis and interferes with differentiation of myoblasts. Our ongoing study indicates that the same pathway is important in endothelial cells in the bone marrow, and that HO-1 deficiency leads to improper function of hematopoietic niche and premature aging of hematopoietic stem cells (HSC). Consequently, my current research is focused on aging of endothelial cells, HSC and hematopoietic niche, interaction of endothelial cells with cancer initiating cells and role of heme metabolism in DNA damage and genome integrity. An important part of my interest is evaluation of animal models in cancer research.
Significant achievements:
1. Contribution in demonstrating the role of heme oxygenase-1 (HO-1) in hematopoietic niche, in protection of hematopoietic stem cells from premature aging.
2. Contribution in elucidating the mechanisms of antimyogenic effects of HO-1 in myoblasts and rhabdomyosarcoma.
3. Contribution in demonstrating the functional effects of HO-1 and HO-1 promoter polymorphism in human endothelial cells.
4. Contribution in construction of gutless adenoviral vectors containing apolipoprotein-E (apoE) for experimental gene therapy of dyslipidemia, and for a long-lasting gene expression in mice. One injection of theses vectors ensured lifetime (2.5 year) transgene expression, correction of cholesterol and apoE levels, and complete protection against atherosclerosis.
Up to five main publications:
1. Nowak WN, Taha H, Kachamakova-Trojanowska N, Stepniewski J, Markiewicz J, Kusienicka A, Szade K, Szade A, Bukowska-Strakova K, Hajduk K, Klóska D, Kopacz A, Grochot-Przeczek A, Barthenheier K, Cauvin C, Dulak J, Jozkowicz A. 2018. Murine bone marrow mesenchymal stromal cells respond efficiently to oxidative stress despite the low level of heme oxygenases 1 and 2. Antioxid Redox Signal 29: 111-127.
2. Ciesla M, Marona P, Kozakowska M, Jez M, Seczynska M, Loboda A, Bukowska-Strakova K, Szade A, Walawender M, Kusior M, Stępniewski J, Szade K, Krist B, Yagensky O, Urbanik A, Kazanowska B, Dulak J, Jozkowicz A. 2016. Heme oxygenase-1 controls an HDAC4-miR-206 pathway of oxidative stress in rhabdomyosarcoma. Cancer Res, 76: 5707-5718.
3. Grochot-Przeczek A, Kotlinowski J, Kozakowska M, Starowicz K, Jagodzinska J, Stachurska A, Volger OL, Bukowska-Strakova K, Florczyk U, Tertil M, Jazwa A, Szade K, Stepniewski J, Loboda A,
Horrevoets AJG, Dulak J, Jozkowicz A. 2014. Heme oxygenase-1 is required for angiogenic function of the bone marrow-derived progenitor cells: role in therapeutic revascularization. Antioxid Redox Signal, 20: 1677-1992.
4. Kozakowska M, Ciesla M, Stefanska A, Skrzypek K, Was H, Jazwa A, Grochot-Przeczek A, Kotlinowski J, Szymula A, Sierpniowska A, Mazan M, Yagensky O, Florczyk U, Lemke K, Zebzda A, Dyduch G, Nowak W, Majka M, Derlacz R, Loboda A, Dulak J, Jozkowicz A. 2012. Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs. Antioxid Redox Signal. 16: 113-127.
5. Taha H, Skrzypek K, Guevara I, Nigisch A, Mustafa S, Grochot-Przeczek A, Ferdek P, Was H, Kotlinowski J, Kozakowska M, Balcerczyk A, Muchova L, Vitek L, Weigel G, Dulak J, Jozkowicz A. 2010. Role of heme oxygenase-1 in human endothelial cells – lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol 30: 1634-1641.
Preferred main research goals for candidate:
Reserch on:
1. Aging of endothelial cells, hematopoietic stem cells and hematopoietic niche.
2. Crosstalk between hematopoietic stem cells/leukemia stem cells and bone marrow niche.
3. Regulation of heme metabolism and its effect on DNA damage and genome integrity.
Specific requirements: Experience in: flow cytometry, next generation sequencing and transcriptome analysis, animal studies, imaging.
Research environment
1. We have well equipped cell culture rooms (biosafety level 2), prepared for isolation, characterization and culture of primary cells, as well as for viral vector production and application. We routinely construct and multiply both plasmid and viral vectors.
2. We have unlimited access to animal facility (SPF standard), with in vivo imaging systems (e.g. IVIS, Vevo2100, Periskan).
3. We have equipment needed for analyzis of gene expression at mRNA and protein levels, pulldown or coprecipitation assays, comet assays, colorimetric, fluorimetric or luminometric assays etc.
4. We have well equipped semi-automated histological lab (with tissue processor, embedding station, stainer, microtome and cryostat), and both histological and immunohistochemical analyzes are routinely performed.
5. We have very well equipped flow cytometry lab with LSR. 6. Fortessa flow cytometer, MoFlo XDP sorter, Image Stream System,
and AutoMACS. We routinely perform multicolor phenotyping and functional analyzes.
7. At the Faculty we also have an access to high-performance liquid chromatographs with spectrophotometric and fluorimetric detectors and access to confocal microscopes.
The most important academic cooperation:
Prof. Irving L. Weissman (Stanford University)
Prof. Qingbo Xu (King’s College, London, UK)
Non-academic cooperation:
Adamed Ltd.
Selvita SA
Supervisor: prof. dr hab. Jolanta Jura (Kwiatkowska – until September 2000)
Contact: [email protected]
Main research field: Molecular biology of the cell: transcript degradation, protein interactions, signalling pathways, transcriptome/proteome profiles in inflammation related processes such as: cancer, metabolic syndrome, skin disorders.
Significant achievements:
Jolanta Jura (maiden name: Kwiatkowska up to 2000) received her Ph.D degree from Medical Academy in Poznan, in 1994. Working in the Human Genetics Institute in Poznan, she was focusing on identification of genes and mutations responsible for selected human diseases. She was a postdoctoral fellow at the Brigham and Women's Hospital, Harvard Medical School in Boston. Working at the Brigham and Women’s Hospital she participated in identification and structural and mutational characteristic of few genes, including TSC1 responsible for tuberous sclerosis. Currently, Jolanta Jura works at the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University. She studies regulation of inflammatory processes, including the role of proteins involved in control of the stability of RNA molecules. Her team described the role of RNase, MCPIP1 in the regulation of degradation of transcripts coding for proinflammatory mediators playing a key role in cancer development, adipocytes differentiation and skin disorders. Jolanta Jura has already published approx. 70 research and review papers in the peer-reviewed journals including, Science, N. Eng. J. Med., FEBS J., Angiogenesis, Oncotarget, Cancer Res.
Preferred main research goals for candidate:
The monocyte chemoatractant protein-induced protein (MCPIP) family consists of four proteins (MCPIP1 - 4) encoded by four genes (Zc3h12a - d in mice and ZC3H12A - D in humans). These are multidomain proteins, however, two of the domains, the zinc finger domain, consisting of three cysteines and one histidine (CCCH), and the PIN domains (N-terminus of the PilT protein (PilT-N-terminus)) determine their function. The PIN domains are about 130 amino acids in length and proteins possessing these domains function as nuclease enzymes that cleave single-stranded RNA in a sequence independent manner. The aim of the work will be to determine the proteins that interact with MCPIP family members and analyze their role in a specific target recognition (mRNA, miRNA). Furthermore, we are interested to study the role of MCPIP1 and MCPIP3 in the regulation of skin homeostasis.
Research environment:
My team of the Department of General biochemistry consists of 4 experienced researchers (including me), 2 postdocs and 7 PhD students, and 1 technician. At our disposal we have 3 large laboratories in which we perform molecular studies and one laboratory in which cell cultures are carried out. Animal testing is carried out at the animal facility. Department is equipped with basic equipment necessary for performing analyzes such as: PCR / real-time PCR, western blot, genetic modifications (transfections / transductions), immunohistochemistry / immunofluorescence.
Structural studies are conducted in collaboration with Prof. Andrzej Joachimiak in the Structural Biology Center (SBC) in Argonne National Laboratory. Furthermore, we have collaboration with Prof. Wim Declercq from VIB/UGent Center for Inflammation and professor Giulia Fontemaggi from IRCCS Regina Elena National Cancer Institute in Rome.
Supervisor: dr Anna Pawlak
Contactl: [email protected]
Main research field:
Oxidative stress and aging of the human retina, lipid oxidation and photoreactivity of polyunsaturated lipids oxidation products, phototoxicity of the eye, plasmalogens in the retina, protective action of tauroursodeoxycholic acid (TUDCA) against photoreceptor photodamage.
Significant achievements:
1. Pawlak A, Olchawa M, Koscielniak A, Zadlo A, Broniec A, Oles T, Sarna TJ (2019) Oxidized Lipids Decrease Phagocytic Activity of ARPE-19 Cells In Vitro. Eur. J. Lipid Sci. Technol.
2. Koscielniak A, Serafin M, Duda M, Oles T, Zadlo A, Broniec A, Berdeaux O, Gregoire S, Bretillon L, Sarna T, Pawlak A (2017), Oxidation-Induced Increase In Photoreactivity of Bovine Retinal Lipid Extract. Cell Biochem. Biophys., 75(3-4): 443-454.
3. Broniec A, Żądło A, Pawlak A, Fuchs B, Kłosiński R, Thompson D, Sarna T. (2017) Interaction of plasmenylcholine with free radicals in selected model systems. Free Radic Biol Med., 106: 368-378.
4. Duda M, Kawula K, Pawlak A, Sarna T, Wisniewska-Becker A. (2017) EPR Studies on the Properties of Model Photoreceptor Membranes Made of Natural and Synthetic Lipids. Cell Biochem. Biophys., 75(3-4): 433-442.
5. Pawlak A, Ito R, Fujii H, Hirata H (2011) Simultaneous molecular imaging based on electron paramagnetic resonance of (14)N- and (15)N-labelled nitroxyl radicals, Chem. Comm., 47 (11): 3245-3247.
6. Broniec A, Klosinski R, Pawlak A, Wrona-Król M, Sarna T (2011), Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems, Free Radic Biol Med., 50(7): 892-898.
7. Beattie J. Renwick; Pawlak AM.; McGarvey John J. and Stitt AW (2011) Sclera as a Surrogate Marker for Determining AGE-Modifications in Bruch's Membrane Using a Raman Spectroscopy-Based Index of Aging. Invest. Ophthalmol. Vis. Sci. 52(3): 1593-1598.
Research grants:
1. “Role of oxidation products of polyunsaturated fatty acids in retinal cells photodamage and contribution of plasmalogens to protection of the retina against oxidative stress” 2013-2016 National Science Centre, Grant nb.: 2012/05/E/NZ3/00473.
2. Analysis of antioxidant action of tauroursodeoxycholic acid (TUDCA) in model systems and in ARPE-19 cells in vitro, 2017-2018, MNiSW, Grant nb.: 35p/11/2017.
Preferred main research goals for candidate:
To elucidate the role of TUDCA in protection of photoreceptors agains photodamage.
To study structural properties of TUDCA in lipid rafts formation in photoreceptor membranes.
To analyse possible cooperation of TUDCA with endogenous antioxidants in retinal cells.
Research environment:
Department of Biophysics at FBBB UJ; Laboratory and infrastructure: nanosecond laser flash photolysis, direct time-resolved detection of singlet oxygen, EPR spectroscopy, cell culture facility, HPLC, fluorescence microscopy, AFM; Academic collaboration: University of Burgundy, France; Aarhus University, Denmark.
FACULTY OF GEOGRAPHY AND GEOLOGY
The faculty, established in 2017, consists of the Institute of Geography and Spatial Management and the Institute of Geological Sciences. It offers first - and second - cycle study programmes in Geography, Spatial E-Management, and Geology as well as PhD programmes.
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Supervisor: prof. dr hab. Marek Michalik
Contact: [email protected]
Main research field: Environmental sciences, mineralogy, geochemistry, petrology, ore deposits.
Significant achievements:
Experience in a broad field: igneous rock petrology, clastic and clay rocks, ore deposits in sedimentary rocks, human-induced modifications of geological processes (e.g. weathering), wastes management and utilization in circular economy, analyses of wastes (e.g. from energy production in coal or biomass fired installations, waste incinerators, mining and mineral processing), anthropogenic components in sediments and soils (industrial technoparticles, microplastics), air pollution, analyses of aerosols particles, urban geochemistry.
(Hirsch index = 18 (WoS))
Preferred main research goals for candidate:
Environmental sciences.
Research environment:
Equipment for mineralogical analyses at the Institute of Geological Sciences (X-ray diffractometry, scanning electron microscopy with chemical microanalysis (EDS), FTIR, optical microscopes, numerous preparatory techniques, air pollution sampler), collaboration with other scientific institutions and external laboratories. Contacts with industrial units.
MALOPOLSKA CENTRE OF BIOTECHNOLOGY
A unique, interdisciplinary and international research institute focused on biomedical sciences, established in 2014. The Biotechnology Centre consists of 19 research groups and independent research laboratories.
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Supervisor: dr Sebastian Glatt
Contact: [email protected]
Main research field:
Structural Biology
https://mcb.uj.edu.pl/en/
http://structuralbiology.pl/
http://glatt-lab.pl/
Significant achievements:
1. Krutyhołowa R*, Zakrzewski K* and Glatt S; Structure and Function of tRNA modifiers; in press, Curr Opin Struct Biol. 2019.
2. Krutyhołowa R*, Hammermeister A*, Zabel R, Abdel-Fattah W, Mazur J, Helm M, Breunig K, Schaffrath R* and Glatt S*, Kti12 is a tRNA dependent ATPase; Nucleic Acids Res. 2019 Mar 27.
3. Lin TY, El Abbassi N, Krutyhołowa R, Zakrzewski K, Chramiec-Głąbik A, Jemioła-Rzemińska M, Różycki J and Glatt S; The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase; Nat Comm 2019 Feb;10(1).
4. Kojic M, Gaik M, Kiska B, Salerno-Kochan A, Hunt S, Tedoldi A, Mureev S, Jones A, Whittle B, Genovesi LA, Adolphe C, Brown DL, Stow JL, Alexandrov K, Sah P, Glatt S*, Wainwright BJ*; Elongator mutation in mice induces neurodegeneration and ataxia-like behavior; Nat Comm. 2018 Aug;9(1).
5. Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Seraphin B, Glatt S*, Müller CW*; Architecture of the yeast Elongator complex, EMBO Rep. 2017 Feb;18(2).
6. Glatt S, Zabel R, Kolaj-Robin O, Onuma OF, Baudin F, Graziadei A, Taverniti V, Lin TY, Baymann F, Séraphin B, Breunig KD, Müller CW; Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi. Nat Struct Mol Biol. 2016 Sep;23(9).
7. Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, He D, Small EM, Mileikovsky M, Holloway AK, Nagy A, Pollard KS, Müller CW & Bruneau BG; Cooperative interactions and locus tethering as the basis for regulation of cardiogenesis by heterotypic
transcription factors; Cell 2016 Feb 25; 164 (5).
8. Hoffmann NA, Jakobi AJ, Moreno-Morcillo M, Glatt S, Kosinski J, Hagen WJH, Sachse C, Müller CW; Molecular structures of unbound and transcribing RNA polymerase III; Nature 2015 Dec 10; 528 (7581).
9. Jeske M, Bordi M, Glatt S, Müller S, Rybin V, Müller CW and Ephrussi A; The crystal structure of the Drosophila germ line-inducer Oskar identifies two domains with distinct Vasa helicase- and RNA-binding activities; Cell Rep. 2015 Jul 28; 12(4).
10. Male G, von Appen A, Glatt S, Taylor NMI, Cristovao M, Groetsch H, Beck M and Müller CW; Architecture of TFIIIC and the role of τ131 in RNA polymerase III pre-initiation complex assembly; Nat Comm. 2015 June 10; 6
11. Glatt S*, Zabel R*, Vonkova I, Kumar A, Netz D, Pierik A, Lill R, Gavin AC, Balbach J, Breunig KD, Müller CW; Kti11/Kti13 structure reveals its dual its role in Elongator dependent tRNA modification and diphthamide biosynthesis; Structure 2015 Jan 6; 23(1).
12. Alfieri C, Gambetta MC, Matos R, Glatt S, Sehr P, Fraterman S, Wilm M, Müller J. & Müller CW; Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements; Genes Dev. 2013 Nov 1;27(21).
13. Glatt S, Müller CW; Structural insights into Elongator function; Curr Opin Struct Biol. 2013 Apr;23(2).
14. Glatt S, Létoquart J, Faux C, Taylor N, Séraphin B and Müller CW; The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase; Nat Struct Mol Biol. 2012 Feb 19;19(3).
Preferred main research goals for candidate:
Structural characterization of large macromolecular complexes using single particle Cryo-EM. Complexes will be either purified from native source using CRISP-based endogenous tagging strategies or via the latest generation insect cell based multi-cistronic expression systems.
Research environment:
The Max Planck research group is a very international research team that offers state-of-art research infrastructure for molecular biology, protein biochemistry, biophysics and structural biology (MX and EM). Foremost, the PI is also responsible for running the national cryo-EM facility at the neighbouring Solaris Synchrotron, which hosts the first Krios G3i cryo transmission electron microscope in Poland. Furthermore, it harbours a Gatan K3 and a Falcon3EC direct electron detectors that allow high resolution imaging of macromolecular complexes.
The MCB offers a fully English speaking research environment, flat hierarchies and a modern open-minded institute culture. In addition, the scientific groups are supported by five centralized core facilities, which facilitate routine processes in the respective research projects. We have several excellent seminar series that allow a vivid exchange of our scientists among each other and the whole world.
Supervisor: prof. dr hab. Grażyna Ptak
Contact: [email protected]
Main research field: Reproductive and developmental biology.
Significant achievements:
For more than 20 years Grażyna Ptak investigations are focused on pregnancy, particularly on implantation and placentation. She has a robust experience in coordinating projects, including the most prestigious ERC Programme IDEAS – Starting Grant, two British Council Grants as well as European 7th FP, Italian and Polish projects. Currently she coordinates H2020-TWINN project (amount of funding: 1 182 500 EUR). She has published 60 relevant papers in peer-reviewed journals, including excellence ones, like Nature Biotechnology and PNAS. She supervised 25 undergraduate students, 10 PhD students and 6 post-doctoral fellows.
Preferred main research goals for candidate:
Developmental Origin of Health and Disease, assisted reproductive technologies, embryo development, placenta, pregnancy.
Research environment:
Grażyna puts particular attention to develop continuously the network of collaborating international researchers, representing both public and private sector. Few years ago Grażyna Ptak was the partner in the big European 7FP intersectoral project (acronym: Fecund, budget 3 000 000 euros) with the involvement of partners (universities and SMEs) from 12 countries. This partnership (and subsequent H2020-Twinning- international project between Poland-Germany-Italy) allowed her to establish to extend networking to new colleagues from all over the Europe. She was actively involved in 3 EU Cost actions, aimed to develop European network of laboratories. Grażyna is very successful in international and intersectoral cooperation. She proved to be able to establish fast and effectively the new laboratories and to motivate and integrate the group of researchers working to reach precise scientific aims.
Supervisor: prof. dr hab. Krzysztof Pyrć
Contact: [email protected]
Main research field: Virology.
Significant achievements: 1. R&D work. Development of effective antivirals (12 patents, one
spin-off, two other companies in the organizational phase, several publications in this topis).
2. Basic science. Understanding the mechanism of infection for several coronaviruses. Publications in the best science journals (e.g., Nature Medicine, Science Translational Medicine, Journal of Virology, PLoS Pathogens, Journal of Medicinal Chemistry).
3. Organization. New & modern BSL3+ and ABSL3 fully equipped units. Dynamic, young team.
Preferred main research goals for candidate:
Topics:
novel antivirals • early stages of the infection • viral proteases • virus-host interactions
Diseases:
respiratory viruses • coronaviruses • flaviviruses • influenza
Models:
In vitro models • 3D tissue cultures • organoids • organ cultures • animal models
Research environment:
The Team: Excellent and vibrant Virogenetics team (http://virogenetics.info, https://www.facebook.com/virogenetics/) consisting of post-doctoral fellows, technicians, PhD students and undergraduate students. In total 20-30 members.
Infrastructure: BSL3+ laboratory allowing for work with highly pathogenic viruses, ABSL3 animal facility, standard BSL2/biochemistry lab. Great structural biology environment. Confocal microscopy. Core facilities.
Collaborations: National and international collaborations with chemistry and virology labs. An example: Horizon2020 Organovir project joining >10 European academic and commercial laboratories to bring the 3D organ cultures to the new level and emply it to understand the disease (https://organovir.com/).
International team.
Collaborations with the commercial sector.
