Lactobacillus acidophilus D2/CSL CECT 4529

HOW TO MAKE YOURPET HEALTHY?

One of the major functions of the gastrointestinal microbiota (or “gut flora”) is the ability to resist the invasion of exogenous organisms, working together with the other host’s non-specific defences and the gut-associated immune system. However, the balance among gastro intestinal (GI) microbial communities change over time, due to physiological and/or environmental causes, including ageing, dietary change, dietary restriction, stress, challenge of pathogens, and antimicrobial treatment.

Some alterations in the GI microbiota, or dysbiosis, can affect animal health, e.g. by lowering the body condition score, or increasing fecal humidity and fecal score. More severe GI dysbiosis can produce profound negative effects on gut physiology and health, including acute and chronic GI inflammation. In human medicine, probiotic lactobacilli have been used to manage a number of disorders related to GI dysbiosis, such as antibiotic-associated diarrhea, intestinal infection, and mucosal inflammation.

GUT FLORA AND GASTROINTESTINAL DYSBIOSIS

POSITIVE INTESTINAL COLONIZATION, without triggering inflammatory responses.

SAFETY for the animal.

BALANCE OF INTESTINAL FLORA restores normal bowel motion and allows the evacuation of well-formed feces.

IMPROVEMENT of the physical fitness and well-being of your pet.

SCIENTIFICALLY proven results, APPROVED by EFSA.

WHAT DOESLactobacillusacidophilus

D2/CSL CECT 4529GUARANTEE

RIGH

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EDIN

G

RIGHT MAN

AGEMEN

T

RIGHT INTESTINAL BACTERIA L. acidophilus D2/CSL CECT 4529

THEAREA

OF GUT HEALTH

1

2

3

4

5

L. acidophilus D2/CSL CECT 4529THE ONLY Lactobacillus STRAIN AUTHORIZED IN EUROPE

L. acidophilus D2/CSL CECT 4529 is a natural inhabitant of the gastrointestinal tract of dogs and cats.

Lactobacilli become established in the GI tract of dogs and cats soon after birth, inhibiting the proliferation of enterobacteria and other unwanted bacteria (e.g. Clostridium perfringens and Escherichia coli ).Unfortunately, the relative abundance of intestinal lactobacilli vary over time, so dysbiosis due to an imbalance between lactobacilli and unwanted bacteria are commonly observed in dogs and cats.

A series of scientific studies provide a clear evidence of L. acidophilus D2/CSL CECT 4529 as “gut flora stabiliser” for dogs and cats. The probiotic positively influences the wellbeing of the animals by increasing their gut health and in turn the quality of their stools, restoring the digestive functions to physiological levels.

In consequence of the improved digestive functions, dogs receiving L. acidophilus D2/CSL (CECT 4529) recover their ideal body condition and fitness.

THE NATURAL SOLUTION

CENTRO SPERIMENTALE DEL LATTE SRLStrada per Merlino, 3 - 26839Zelo Buon Persico (Lodi) - ItalyPhone: +39.02.90696.1 - Fax: +39.02.90696.99 saccosystem.com

CLINICAL TRIALSThree studies on dogs, and one study on cats have been carried out to evaluate the efficacy of L. acidophilus D2/CSL supplementation on the GUT HEALTH and BODY CONDITION SCORE of dogs and cats.Studies provide a clear evidence of efficacy of the probiotic Lactobacillus acidophilus D2/CSL (CECT 4529) as gut flora stabiliser for dogs and cats.

• 1. Lactobacillus acidophilus D2/CSL (CECT 4529) BALANCES THE INTESTINAL MICROBIOTA. • 2. This IMPROVES THE GUT HEALTH, pointed out by the parameters of faecal consistency. • 3. Both balanced intestinal microbiota and normalized digestive functions lead to ANIMAL WELL-BEING.

L. acidophilus D2/CSL CECT 4529Natural cells for the well-being of your pet!

4,9

5

5,1

5,2

5,3

4,8

4,7

4,6

4,5

4,4

CONTROL D2

4,67 5,17

ENGLISH COCKER SPANIEL DOGSBody condition score after - 35 days

3

3,1

3,2

3,3

3,4

2,9

2,8

2,7

2,6

2,5

CONTROL D2

3,12 2,75

ENGLISH COCKER SPANIEL DOGSImprovement of faecal score - 35 days

4,75

4,8

4,85

4,9

4,95

4,7

4,65

4,6

4,55

4,5

CONTROL D2

4,65 4,86

BOXER DOGSBody condition score after - 35 days

4

4,1

4,2

4,3

4,4

3,9

3,8

3,7

3,6

3,5

CONTROL D2

4,25 3,78

BOXER DOGSImprovement of faecal score - 35 days

4,75

4,8

4,85

4,9

4,95

4,7

4,65

4,6

4,55

4,5

CONTROL D2

4,63 4,94

LABRADOR DOGSBody condition score after - 35 days

3,4

3,5

3,6

3,7

3,8

3,3

3,2

3,1

3

2.9

CONTROL D2

3,58 3,19

LABRADOR DOGSImprovement of faecal score - 35 days

45,5

46

46,5

47

47,5

45

44,5

44

43,5

43

CONTROL D2

46 44

MAINE COON CATSLowering of faecal moisture % - 35 days

3,6

3,7

3,8

3,9

4

3,5

3,4

3,3

3,2

3,1

CONTROL D2

3,75 3,35

MAINE COON CATSImprovement of faecal score - 35 days

DOSAGE

5X109

CFU/kg food

USAGE

A good dailydietary practice

Lactobacillus acidophilus D2/CSL (CECT 4529) re-establishes the WELL-BEING OF YOUR DOGS AND CATS: - By restoring their NORMAL GUT HEALTH - By restoring the NORMALITY OF THEIR STOOLS- By restoring their NORMAL DIGESTIVE FUNCTIONS

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