How to summarize & effectively share the findings?

Ana Maria Henao-RestrepoInitiative for Vaccine Research

Optimizing Immunization SchedulesHOW to share the findings?

• It is key to effectively synthesize and share the findings

• A web-based repository will help to ensure open & transparent availability to all interested parties.

• It should be in a form which facilitates regular updates, as new studies are carried out and as experience accumulates.

Information provided must be:

equitable

locally

relevant

usableavailable

comparable

understanda

ble

credible

BETA VERSIONWORK IN PROGRESS…

Optimizing Immunization Schedules

web-based interface – next steps

• To examine websites and experiences from groups with long term experience with the development of such knowledge sharing platforms (e.g. PROVAC, BMJclinicalevidence, WHO-EVIPNET..).

• To finalize the structure and data requirements of the website and outline the system for data management.

• To design summaries, tables and figures that can be used to effectively communicate the outcomes of the systematic reviews.

• To establish a web-based data management facility.

Acknowledgements

• LSHTM, UK• Univ of Bern, Switzerland• Univ Bocconi, Italy• Agence Medicine Preventive, France• HPA, UK

• Research sites: MRC, The Gambia;WT- Kiliffi, Univ Ben Gurion, Israel

• Vaccine experts: PCV, Rota, Hib, Pertussis

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Slide courtesy of Yvan Hutin

How to summarize the FINDINGS ?

Schedule A

Schedule B

Schedule C

Schedule D

Overall summary of findings

Limitations of the evidence

Clinical endpoints

Randomized clinical trials

Observational studies

Immunogenicity/efficacy/effectiveness

Randomized clinical trials

Observational studies

Safety profile

Evidence gaps/research needs