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Hoying, James B January, 2016
1
VITAE
JAMES B. HOYING, Ph.D.
Current Positions: Chief, Division of Cardiovascular Therapeutics
Cardiovascular Innovation Institute
University of Louisville, Jewish Hospital/St. Mary’s Healthcare
302 E Muhammad Ali Blvd
Louisville, KY 40202
502-852-2170
Professor
Department of Physiology and Biophysics
University of Louisville
President and CEO
Angiomics, Inc.
Tucson, AZ
502-377-0112
EDUCATION
Post-Doctoral Fellow: Program of Excellence in Molecular Biology of the Heart and Lung,
NHLBI, NIH, 1998
University of Cincinnati, Cincinnati, OH
Department of Molecular Genetics
Major Field: Molecular Genetics, Genetic Mouse Models
Research: Molecular Mechanisms of Cardiovascular Disease and Cancer
Advisor: Tom Doetschman, PhD
Doctor of Philosophy: University of Arizona, Tucson, AZ, 05/1994
Physiological Sciences Graduate Program
Major area: Cardiovascular Physiology
Minor area: Cancer Biology
Dissertation: Cell-Matrix Interactions of Microvessel Endothelial Cells in
Response to Basic Fibroblast Growth Factor
Advisor: Stuart K. Williams, PhD
Master of Science Case Western Reserve University, Cleveland, OH, 1987
Department of Biology
Major area: Molecular and Cellular Biology
Minor area: Biotechnology
Hoying, James B January, 2016
2
Thesis: Cloning and Characterization of Rhizobium Meliloti Loci Required
for Symbiotic Root Nodule Invasion.
Advisor: Naomi Lang-Unnasch, PhD
Bachelor of Arts: Case Western Reserve University, Cleveland, OH, 1985
Department of Biology
Major area: Biology
Minor area: Biochemistry
Senior Project: Tobacco Meristem Culture Methods
PROFFESIONAL EXPERIENCE
20014-present Professor* Department of Physiology and Biophysics,
University of Louisville
Louisville, KY
*primary appointment switched to
Physiology from Surgery.
2008-2014 Professor* Dept. of Surgery
University of Louisville
Louisville, KY
2007-present Chief Division of Cardiovascular Therapeutics,
Cardiovascular Innovation Institute
University of Louisville
Jewish Hospital/St. Mary’s Healthcare,
Louisville, KY
2007-2008 Associate Professor Department of Surgery, University of
Louisville, KY
2003-2008 Associate Professor Division of Biomedical Engineering
Arizona Research Laboratories
University of Arizona, Tucson, AZ.
2003-2008 Associate Professor Department of Physiology
University of Arizona, Tucson, AZ
2000-2003 Assistant Professor Department of Physiology
University of Arizona, Tucson, AZ
1998-2003 Assistant Professor Division of Biomedical Engineering
Arizona Research Laboratories
Hoying, James B January, 2016
3
University of Arizona, Tucson, AZ
1994-1998 New Investigator Program of Excellence in Molecular
Biology of the Heart and Lung, NHLBI,
NIH
Department of Molecular Genetics
University of Cincinnati, Cincinnati, OH
ENTREPRENEURIAL EXPERIENCE
2010-present Co-founder Riviera Medical Technologies LLC
Louisville, KY
Technologies for cell-based therapies.
2004-present Co-founder and President-CEO Angiomics, Inc.
Tucson, AZ
Solutions for improving vascular health.
PROFESSIONAL MEMBERSHIP
North American Vascular Biology Organization (NAVBO), 2007-present
American Physiological Society, 1992-present
The Microcirculatory Society, 1992-present
American Heart Association, ATVB Council, 1998-present
International Society for Applied Cardiovascular Biology, 1998-present
Member, Sarver Heart Center, University of Arizona, 2001-08
Member, Physiological Sciences Graduate Program, University of Arizona, 1999-07
Hoying, James B January, 2016
4
PROFESSIONAL ACTIVITIES/SERVICE
Visiting Scientist and B Project Leader, Payload Team CCM-STS-118, Space Shuttle Flight STS-116.
NASA, Kennedy Space Center, FL, 2007
External Review
NIH/NIBIB Special Emphasis Panel/Scientific Review Group ZEB1 OSR-D (M2) P41 meeting,
October 2016
NIH/NIBIB Special Emphasis Panel NIBIB QUANTUM: Technological Innovation to Solve a Major
Medical or Public Health Challenge (U01) June 2016
NIH/NIBIB Special Emphasis Panel/Scientific Review Group ZEB1 OSR-D (M2) P41 meeting,
February 2016
NIH/NIBIB, Site Visit Review Panel, P41 National Resource Center for Biomaterials and Biofabricated
Platforms, March 2015
NIH, Lung Injury, Repair, and Remodeling Study Section, Ad Hoc reviewer, 2012
NIH, Special Emphasis Panel/Scientific Review Group ZHL1 CSR-V M1, 2011, 2012
NIH, Special Emphasis Panel/Scientific Review Group ZRG1 F10A-S 20, 2010
NIH, Special Emphasis Panel/Scientific Review Group ZRG1 CVRS-F 52, 2009, 2010
NIH, Special Emphasis Panel/Scientific Review Group ZRG1 CVRS-B 58, 2009
NIH, Special Emphasis Panel/Scientific Review Group ZRG1 CVS-P-02, 2008
NIH, CDD Study Section, Ad Hoc reviewer, 2007
NIH, Special Emphasis Panel/Scientific Review Group ZAG1 ZIJ, P01 review, 2005, 06
NIH, Special Emphasis Panel, Advances in Tissue Engineering Reparative Medicine Study Section,
2003
NIH, Mentored Scientist Development Award Study Section, 2003
NIH, NCI, U54/Interdisciplinary Teams in Molecular Targets, Special Emphasis Panel, Angiogenesis,
2000Invited external reviewer, Faculty Promotion and Tenure Review, Department of
Biomedical Engineering, Tulane University, Charlottesville, 2014
VA-ORD, Special Emphasis Panel/Scientific Review Group 2011/05 RRDO 1, 2011
American Heart Association, Vascular Biology & Blood Pressure/Regulation Basic Science 3, 2011-
present, Co-chair.
American Heart Association, Vascular Wall Biology I study section, Great American Affiliate,
American Heart Association, 2008, 2009, Chair.
American Heart Association, Combined GRA & National Peer Review Group, Vascular Wall Biology
I, 2001-2009
Hoying, James B January, 2016
5
American Heart Association, Affiliate 2B (Vascular Wall Biology) Research Peer Review Group,
1999-2001
Israel Science Foundation, Individual Research Grant, Invited Reviewer. 2013
ZonMw, Netherlands Organisation for Health Research and Development, TOP Grant Program, Invited
Reviewer. Netherlands, 2011, 2012, 2016
Invited external reviewer, Faculty Promotion and Tenure Review, Department of Molecular & Cellular
Medicine, Texas A&M, 2011
Invited external reviewer, Faculty Promotion and Tenure Review, Department of Bioengineering,
University of Virginia, Charlottesville, 2014
Conference Organization/Leadership
Invited Member, Scientific Advisory Committee; International Conference on Biofabrication 2016,
Winston-Salem, NC October 2016.
Invited Member, International Scientific Program Committee, World Congress for Microcirculation,
Kyoto, Japan, (WCMic2015) 25-27 September, 2015.
Organizer and Chair, Microvascular Plasticity Symposium, World Congress for Microcirculation,
Kyoto, Japan, (WCMic2015) 25-27 September, 2015
Organizer and Chair, Regenerative Medicine Track, Global Biotechnology Conference, Boston, MA,
July 2015.
Organizing Committee, International Academy of Cardiovascular Sciences - America Section,
Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators in
Louisville, Kentucky on August 15-17, 2013, 2012
Invited Session Moderator, SESSION 6 Translational Sciences, IFATS International Conference, 2011.
Organizer and Chair, American Physiological Society-Sponsored Symposium entitled Genomics of
Angiogenesis and the Microcirculation, Experimental Biology Meeting, San Diego, CA, 2003
Organizing Committee, Weinstein Cardiovascular Development Conference held in Tucson, AZ, 1999
Session Chair, Selected Featured Topics Session, American Physiology Society, FGF Physiology,
Experimental Biology meeting, San Francisco, CA, 2006
Session Chair, Selected Vasculogenesis/Angiogenesis Feature Topics Platform. Experimental Biology
meeting, Washington, DC, 2004
Outreach
Program Director and Mentor, Junior Achievement of Kentucky Scholars Program, Jefferson County
Public High Schools. 2012, 2013, 2016.
Hoying, James B January, 2016
6
Invited guest instructor, Westport Middle School, Dana Hoben AP Biology Classes. Louisville KY,
2013.
Invited guest panelist, The Heart Facts, Kentucky Health 360 television series, Kentucky Educational
Television (KET) Network, 2012
Mentor, Speed Mentoring Sessions, 2011 Youth Science Summit, Louisville Science Center,
Louisville, KY, 2011
Invited Speaker, AP Biology classes, BASIS School, 2004
Faculty Mentor for Summer Institute Medical Ignorance, High School and Science Teacher Research
Fellows, Marlys Witte, Director, 2002
Invited Speaker, Medical Studies group, Catalina High School, Tucson AZ, 2001-02
Participant, Southwest BioPartnering Expo, 2001-02
Participant, Med Camp, 2000-06
Invited speaker, Medical Issues class, Catalina High School, Tucson AZ, 2001
Invited speaker, AP Biology class, Sabino High School, Tucson AZ, 2001
Participant, Phoenix HS Career Day, Public Affairs/College of Medicine, 2001
Judge, Life Sciences/Social Behavior, Science Fair Competition K-12, Southern Arizona Regional
Science and Engineering Fair (SARSEF), Tucson AZ, 1999-06
Faculty Mentor, NSF Summer Intern Program for High School Science Teachers, Dr. Supapan
Seraphin, Director, Tucson AZ, 1999-00
Invited speaker, Cactus Civitan, Tucson AZ, 1999
Invited speaker, Saguaro Rotary Club, Tucson AZ, 1999
Correspondent, American Society of Cell Biologists (ASCB) Letter to Young People Program, 1995-97
HONORS, AWARDS, AND RECOGNITION
Honors Recognition, An exclusive license with Tissue Genesis, Inc. for Adipose Stromal Vascular
Fraction Cell Epicardial Patch, Celebration of Faculty Excellence, University of Louisville,
2012
University Scholar re-appointment, University of Louisville, Louisville, KY, 2012
Honors Recognition, An exclusive license with Tissue Genesis, Inc. for a Adipose Stromal Cells to
Support Transplanted Tissue Integration and Inosculation, Celebration of Faculty Excellence,
University of Louisville, 2011
Fellow of the American Heart Association, Basic Cardiovascular Sciences (BCVS) Council, 2011
University Scholar, University of Louisville, Louisville, KY, 2008
Hoying, James B January, 2016
7
Keynote Address Speaker, Workshop in: Blood Flow in the Microcirculation: Function, Regulation
and Adaptation, Mathematical Biosciences Institute, Ohio State University, 2007
Taylor & Francis prize for Outstanding Innovation in Computer Methods in Biomechanics &
Biomedical Engineering, 6th International Symposium on Computer Methods in Biomechanics
and Biomedical Engineering, Team Member, 2004
Harry Rudney Post-Doctoral Merit Award, Department of Molecular Genetics, University of
Cincinnati, 1998
Research Merit Award, Post-Doctoral Research Poster Competition, University of Cincinnati/Ohio
Physiological Society, 1997
Travel Fellowship and Section Co-chair, Young Scientists Pre-meeting at Asilomar, 17th International
Congress of Biochemistry and Molecular Biology, 1997
Travel Award, Vascular Biology Meeting, 1997
Innovative Instrumentation Award, Microcirculatory Society, 1995
Proctor and Gamble Professional Opportunity Award for Meritorious Research, American
Physiological Society, Cardiovascular Section, 1994
National Heart, Lung, and Blood Predoctoral Trainee, University of Arizona. 1992-94
Physiological Sciences Scholarship Award, University of Arizona, 1993-94
Sigma Xi Research Award, 1992
1st place winner in Staff Division, Physiological Society of Philadelphia Poster Competition, 1991
Hoying, James B January, 2016
8
UNIVERSITY COMMITTEE ASIGNMENTS
Chair, Institutional Biosafety Committee, University of Louisville, 2015-present
Member, Faculty Search Committee, Director of the Center for Preventative Medicine, 2015.
Chair, Faculty Search Committee, Cardiovascular Innovation Institute, 2008
Member, Cardiovascular Innovation Institute, Building Design/Programming Committee,
Cardiovascular Innovation Institute, 2008
Member, Institutional Biosafety Committee, University of Louisville, 2008-present
Member, Cardiovascular Sciences Steering Committee, College of Medicine, University of Arizona,
2005-06
Member, Bio5/COM Search Committee for Mouse Transgenesis Faculty Director, University of
Arizona, 2005
Member, MSE Biomaterials Faculty Search Committee, University of Arizona, 2005
Member, AHSC Continuing Medical Education committee, University of Arizona, 2004
Member of the Medical Research Building Design Committee, AHSC, University of Arizona, 2003
Member, Selection Committee for BIO5 Predoctoral Fellowships, University of Arizona, 2003-04
Member of the Mouse Users Group Steering Committee headed by Dr. Parker Antin (CBA), University
of Arizona, 2003-06
Search Committee, Bioinformatics Faculty Positions in the IBSB, University of Arizona, 2002
Chairman, Recruiting/Admissions Committee for the Biomedical Engineering IDP, University of
Arizona, 2001-07
GATC Steering Committee, Arizona Research Labs, University of Arizona, 2000-07
Chairman, Activities Committee, Physiological Sciences Graduate Program, University of Arizona,
2000-02
Chairman, Resources Committee for the Biomedical Engineering IDP, University of Arizona, 1999-01
Executive Committee Member, Biomedical Engineering Graduate Program, University of Arizona,
1999-07
Executive Committee Member, Physiological Sciences Graduate Program, University of Arizona,
1999-07
UNIVERSITY SERVICE
Director, Multi-photon Confocal Microscopy Core, Cardiovascular Innovation Institute/Kentucky
Spinal Cord Injury Research Center, University of Louisville, 2010-present
Grant Pre-Submission Review Panel, Department of Surgery. University of Louisville, 2011-2014
Hoying, James B January, 2016
9
Assessments of faculty activities, 5-year Periodic Career Review, University of Louisville School of
Medicine, 2012
Mentor, Faculty Mentoring Program, School of Medicine, University of Louisville, 2011-present
Director/Management, Good Laboratory Practice (GLP) and Good Tissue Practice (GTP) Facilities,
Cardiovascular Innovation Institute, 2010-present
Faculty Search for Rodent Veterinary Staff Member, RRC, University of Louisville, 2009
Co-organizer for the Quantitative Approaches to Cell Signaling Workshop sponsored by the Applied
Mathematics IGERT, University of Arizona, 2003
Co-organizer and Co-chair for the Bi-annual Angiogenesis Workshop sponsored by Biomedical
Engineering Program, University of Arizona, 2002
Presentation on BioNanotechnology, College of Engineering and Mines Faculty Meeting, Promotion of
Interdisciplinary Research, University of Arizona, 2001
Founder/Co-Director, Genomics Research Laboratory, University of Arizona, 2000-2007.
Grant Reviewer, Clinical Faculty Research Fellowship Program, Robert S. Flinn Foundation, Arizona,
2000
Grant Reviewer, Pilot Projects Program in the SWEHSC, University of Arizona, 2000-06
Grant Reviewer, Pilot Projects Program, Dept. of Ophthalmology, University of Arizona, 2000-present
Grant Reviewer, Clinical Faculty Research Fellowship Program, Robert S. Flinn Foundation,
University of Arizona, 2000-06
Organizer and Chair for the Bi-annual Angiogenesis Workshop sponsored by Biomedical Engineering
Program, University of Arizona, 2000
Essay grader for the University’s Upper-Division Writing-Proficiency Examination (UDWPE),
University of Arizona, 1999, 01
Member of the Transgenic Mouse Users group headed by Dr. Bob Erickson (Pediatrics), University of
Arizona, 1998-05
Organizer/Coordinator, Vascular Research Group, University of Arizona, 1998-07
Co-organizer and Co-chair for the Bi-annual Angiogenesis Workshop sponsored by Biomedical
Engineering in cooperation with the Cancer Center, U. of Arizona, 1998
PROFFESSIONAL COUNCILS/BOARDS
Member, Membership Committee, the Microcirculation Society, 2012-2015
Associate Editor, Frontiers in Vascular Physiology, 2010-present
Member, Editorial Board, the Microcirculation journal, 2010-present.
Member, Executive Research Steering Committee, Pacific Mountain/West Region, American Heart
Hoying, James B January, 2016
10
Association, 2005-07
Member, Desert Mountain Affiliate Research Committee, American Heart Association, 2002-05
MANUSCRIPT PEER REVIEW
─ Acta Biomaterialia
─ American Journal of Pathology
─ American Journal of Physiology
─ Applied Optics
─ Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
─ Biotechniques
─ Biotechnology Progress
─ Cell Transplantation
─ Circulation Research
─ Developmental Dynamics
─ Frontiers in Vascular Physiology
─ Journal of the American Medical Association
─ Journal of Applied Physiology
─ Journal of Vascular Research
─ Journal of Visualized Experiments (JOVE).
─ Microcirculation
─ Microvascular Research
─ Nature Medicine
─ Nature Protocols
─ Physiological Genomics
─ PLoS One
─ Proceedings of the National Academy of Sciences (PNAS)
─ Stem Cell Translational Medicine
─ Tissue Engineering
Hoying, James B January, 2016
11
TEACHING
Courses/Lecturing
Spring 2016
Lecturer, PHZB 611: Advanced Human Cardiovascular Physiology, 4 credits, 7 graduate
students
Lecturer, NSCI 600: Translational Neurosciences, 3 credits, 8 graduate students
Fall 2016
Discussion leader, PHZB 609: Integrated Systemic Physiology, 3 credits, 4 graduate students
Spring 2009
Course Coordinator/Instructor, BE 400: Special Topics: Anatomy and Physiology 3 credits, 25
undergraduate students
Spring 2007
Course Organizer, BME 597G: Laboratory Rotations, 1-3 credits, 2 graduate students
Course Coordinator and lecturer, BME 511: Physiology for Biomedical Engineers, 3 credits,
13 graduate students
Instructor, BME 599: Independent Study in Biomedical Engineering, 1 credit, 2 graduate
students
Section Organizer and Lecturer, PSIO 603: Systems Physiology, Cardiovascular Physiology
section, 6 credit, 15 graduate students
Instructor, PSIO 610: Research Methods in Physiology, 1 credit, 1 graduate student
Fall 2006
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 4 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
20 graduate students
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 20 graduate
students
Course Organizer and lecturer, BME 576, Microvascular Biology, 3 credits, 8 graduate
students.
Spring 2006
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Hoying, James B January, 2016
12
Course Coordinator and lecturer, BME 511: Physiology for Biomedical Engineers, 3 credits,
17 graduate students
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 20 graduate students
Fall 2005
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
14 graduate students, 13 undergraduates
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 19 graduate
students
Spring 2005
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Course Coordinator and lecturer, BME 411/511: Physiology for Biomedical Engineers, 3
credits, 16 graduate students, 23 undergraduate students
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 21 graduate students
Fall 2004
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
15 graduate students, 13 undergraduates
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 27 graduate
students
Spring 2004
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Course Coordinator and lecturer, BME 411/511: Physiology for Biomedical Engineers, 3
credits, 15 graduate students, 17 undergraduate students
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 15 graduate students
Fall 2003
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
13 graduate students, 10 undergraduates
Hoying, James B January, 2016
13
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 17 graduate
students
Spring 2003
Facilitator, iPBL Biochemistry, 9 medical students (see attached letter from Dr. Louise
Canfield)
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 1 graduate students
Course Coordinator and lecturer, BME 411/511: Physiology for Biomedical Engineers, 3
credits, 8 graduate students, 16 undergraduate students
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 13 graduate students
Fall 2002
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 4 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
13 graduate students, 14 undergraduates
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 15 graduate
students
Spring 2002
Facilitator, iPBL Biochemistry, 9 medical students.
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 6 graduate students
Course Coordinator and lecturer, BME 411/511: Physiology for Engineers, 3 credits, 8
graduate students, 11 undergraduate students
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 12 graduate students
Fall 2001
Lecturer, MATH 596a: IGERT Forum, 2 credits, 15 graduate students
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 4 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
9 graduate students, 5 undergraduates
Lecturer, SURG 596I: Molecular Cardiovascular Biology, Genetic Models and Angiogenesis
lectures, 3 credits, 10 graduate students
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 20 graduate
students
Hoying, James B January, 2016
14
Spring 2001
Facilitator, iPBL Biochemistry, 9 medical students
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 6 graduate students
Course Coordinator and lecturer, BME 411/511: Physiology for Engineers, 3 credits, 9
graduate students, 13 undergraduate students
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 12 graduate students
Fall 2000
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 8 graduate students
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
14 graduate students, 10 undergraduate
Lecturer, SURG 596I: Molecular Cardiovascular Biology, Genetic Models and Angiogenesis
lectures, 3 credits, 8 graduate students
Lecturer, PSIO 503: Cell Physiology, Physiological Genomics lectures, 5 credit, 18 graduate
students
BME 597x: Research methods, 2 credit, 2 graduate students
BME 900: Research, 8 credits, 2 graduate students
Spring 2000
Facilitator, iPBL Biochemistry, 8 medical students
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 10 graduate students
Course Coordinator and lecturer, BME 411/511: Physiology for Engineers, 3 credits, 10
graduate students, 11 undergraduate
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 8 graduate students
Fall 1999
Course Organizer, BME 597: Laboratory Rotations, 1-3 credits, 12 graduate students
Course Coordinator, BME 595a: Topics in Tissue Engineering, 1 credit, new permanent course
Course Coordinator and lecturer, BME 410/510: Biology for Biomedical Engineers, 3 credits,
14 graduate students
Spring 1999
Course Co-Coordinator and lecturer, BME 411/511: Physiology for Engineers, 3 credits, 13
graduate students, 5 undergraduate students
Hoying, James B January, 2016
15
Session Facilitator, PSIO 602: Readings in Systems Physiology, Cardiovascular Physiology
section, 1 credit, 8 graduate students
Fall 1998
Co-Coordinator and lecturer, BME 510: Biology for Biomedical Engineers, 3 credits, 12
graduate students
Fall 1997
Co-Originator, EHS 848: Introduction to Bioinformatics and Biocomputing, 3 credits, 8
graduate students, University of Cincinnati
Spring 96, 97
Lecturer, DB 852: Developmental Biology I, Molecular Basis of Gastrulation Lecture, 5 credits,
15 graduate students, University of Cincinnati
Course Development
BE 400 Special Topics: Anatomy and Physiology for Bioengineering: Developed course syllabus and
content.
BME 576, Microvascular Biology, Course Founder, Co-developed syllabus and materials.
PSIO 603, Systems Physiology, Initiated restructuring of the course and participated in the redesign of
course content.
BME 410/510, Biology for Biomedical Engineering, Assisted in the development of course syllabus
and reading materials
BME 411/511, Physiology for Biomedical Engineering, Assisted in the development of course syllabus
and reading materials
BME 595A, Developed course syllabus and reading lists
BME 597, Research Methods in Biomedical Engineering, Re-designed lab rotation format and
reporting
iPBL (integrated Problem-Based Learning) Biochemistry, Assisted in the redesign of the iPBL Program
for 1st year med students
Journal Clubs and Discussion Groups
Coordinator, CII Regenerative Medicine Journal Club, 2009-present
Faculty Advisor, Cardiovascular Engineering Journal Club, 2004-2007
Hoying, James B January, 2016
16
Coordinator, Vascular Research Group, Faculty, Fellows, Post-Docs, Graduate Students,
Undergraduate Students, 1998-2007
Transgenics Users Group, Faculty, Fellows, Post-Docs, Graduate Students, Undergraduate Students,
1998-2007
TRAINING/MENTORING
Faculty
Paula Chilton, PhD Research Asst. Professor, Department of Surgery, Christina M. Kleinert Research
Institute, University of Louisville, 2015-present
Marvin Morris, MD, Assistant Professor, Division of Vascular Surgery, Department of Surgery,
University of Louisville, 2010-2013
Chad Stiening, PhD, Research Translation and Advancement. Chief Science Officer, KyPha, Inc.,
Louisville, KY, 2009
Sabbatical Host for Dr. Srini Raghavan, PhD, Material Science and Engineering Dept., University of
Arizona, 2006
Post-Doctoral Fellows (degree institution, research area, current position)
Amanda LeBlanc, PhD, (West Virginia University), Coronary microcirculatory repair. Assistant
Professor, OB/GYN University of Louisville, Cardiovascular Innovation Institute, 2009-2012
Carlos Chang, PhD, (University of Arizona), Microvascular network formation and engineering. Staff
Scientist, St. Joseph Translational Research Institute, Atlanta GA, 2008-2011
Laxminaryanan Krishnan, PhD, (University of Utah), Prevascularized islet transplantation device.
Senior Research Fellow, Georgia Institute of Technology, Atlanta, GA, 2008-2012
Sara Vasconcelos, PhD, (University of Alabama Birmingham), Angiogenesis guidance and
inosculation. Assistant Scientist, University Health Network, University of Toronto, Toronto,
Cananda, 2008-2010
Chad Stiening, PhD, (University of Arizona), Post-angiogenesis genetics. Chief Science Officer,
KyPha, Inc., Louisville, KY 2007-2009
Gabriel Gruionu, PhD, (University of Arizona), Microvessel-polymer interactions. Research Fellow,
Steele Laboratory of Tumor Biology at the Massachusetts General Hospital/ Harvard Medical
School, 2005-2007
Kameha Kidd, PhD, (University of Arizona), Tissue revascularization. Health Science Policy Analyst,
NIH/NCRR, Bethesda, MD, 2003
Chris Sullivan, PhD, (University of Arizona), Microvascular Remodling. Associate Professor, A.T. Still
Hoying, James B January, 2016
17
University, Phoenix, AZ, 2002-2003
Residents/Fellows
John Maijub, MD, Research Fellow, Department of Surgery, Regenerative Cell Dosing for Vascular
Repair, 2011-2013
Tolga Turker, MD, Research Fellow, Christine M. Kleinert Institute for Hand and Microsurgery; the
University of Louisville School of Medicine; the Kleinert Kutz Hand Surgery Group, 2011-
2012
Babak Salimi, MD Chief Resident, Pediatric Intensive Care, Capillary leak syndrome in post-cardiac
surgery pediatric patients. Assistant Professor, Indiana University Pediatric Intensive Care,
2011-2012
Sitara Kommareddi, MD, Microvascular gene expression. Surgical Resident Research Fellow, General
Surgeon, Saguaro Surgical. Tucson, AZ, 2001
Graduate students
Mentored students (date degree awarded, degree program, research area, current position)
Katlin Stivers, current PhD, Microbiology & Immunology, University of Louisville, Louisville KY
Logan Curtis-Whitchurch, current PhD, Physiology, University of Louisville, Louisville KY
Venkat Ramakrishnan, PhD 2015, MD/PhD Program, University of Louisville, currently completing
MD degree at the UofL.
Carlos Chang, PhD 2008, Biomedical Engineering, Microvascular Fabrication, Staff Scientist, St.
Joseph Translational Research Institute, Atlanta GA
Trevor Cardinal PhD, 2007, Physiological Sciences, Post-ischemia vasoreactivity, Asst. Professor,
Dept. of Bioengineering, Cal Poly San Luis Ibispo
Kevin Greer, PhD 2006, Biomedical Engineering, Computational genomics, Computational Genomic
Scientist, BIO5 Institute, University of Arizona
Mark Schwartz, PhD 2005, Biomedical Engineering, Genetics of biomaterials compatibility, Staff
Scientist, High-Throughput Genomics Inc.
Gabriel Gruionu, PhD 2004, Biomedical Engineering, Vascular remodeling, Research Fellow, Steele
Laboratory of Tumor Biology at the Massachusetts General Hospital/ Harvard Medical School
Chris Sullivan, PhD 2002, Physiological Sciences, FGF2 in vascular repair, Associate Professor, Dept.
of Biological Sciences, A.T. Still University, Phoenix AZ
Hoying, James B January, 2016
18
Ebonie Armstrong, current MS, Physiology, University of Louisville, Louisville KY
Maurice Jabbour, MS 2007, Biomedical Engineering, Antibody array-based detector, Post-doc,
Microbiology & Immunology, University of Arizona
Greg Dion, MS 2005 Biomedical Engineering, Biological-based sensing, Medical Student
Adam Budoff, MS 2000, Biomedical Engineering, Vascular microarray, Manager - Microarray
Services at AltheaDx
Service on Dissertation/Thesis Committee
Kathryn Deveau, (Anat. Sci and Neurology, University of Louisville), PhD current
Kathryn Harman, (Anat. Sci and Neurology, University of Louisville), PhD current
Adeola Adeyemo, (Pharmacology, University of Cincinnati), PhD current
Sauyma Vanderwyst, (Biomedical Engineering, University of Arizona), PhD 2011
Carlo Bartoli, (MD/PhD Program, University of Louisville), PhD 2011
Renata Ramos (Biomedical Engineering, University of Arizona), PhD 2008
Sharon Rodriquez (Physiological Sciences, University of Arizona), PhD 2008
Laxminarayan Krishnan (Bioengineering, University of Utah), PhD 2008
Alton Hiscox (Physiological Sciences, University of Arizona), PhD 2007
Kristen O'Hallorhan (Biomedical Engineering), University of Arizona, PhD 2007
Heather Salazaar (Physiological Sciences, University of Arizona), PhD 2006
Sam Powis (Biomedical Engineering, University of Arizona), PhD 2005
Jingyu Guo (Physiological Sciences, University of Arizona), PhD 2005
Cindy Smith (Biomedical Engineering, University of Arizona), PhD 2005
Yi Yang, (Material Science and Engineering, University of Arizona), PhD 2004
Jon Alberding (Biomedical Engineering, University of Arizona), PhD 2004
Ben Shepherd (Physiological Sciences, University of Arizona), PhD 2004
Brooke McGuire (Biomedical Engineering, University of Arizona), PhD 2003
Kameha Kidd (Physiological Sciences, University of Arizona), PhD 2002
Rob Kellar (Physiological Sciences, University of Arizona), PhD 2001
Don DalPonte (Physiological Sciences, University of Arizona), PhD 2001
William Brands (Biomedical Engineering, University of Arizona), MS2007
Hoying, James B January, 2016
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Matt McReynolds (Physiological Sciences, University of Arizona), MS 2006
Richard Cangelosi (Applied Mathematics, University of Arizona), MS 2005
Jamie Dibble (Biomedical Engineering, University of Arizona), MS 2005
Sarah Swaim, (Biomedical Engineering, University of Arizona), MS 2004
Undergraduate Research
Erik Schuschke, Summer Undergraduate Research Program in Cardiovascular Research for Under-
represented Minorities and Disadvantaged Students, University of Louisville, 2015
Ebonie Armstrong, Summer Undergraduate Research Program in Cardiovascular Research for
Under-represented Minorities and Disadvantaged Students, University of Louisville,
2014
Kadi Simmons, HHMI Summer Research Program, Georgetown College, 2014
Andrea Howard, HHMI Summer Research Program, Georgetown College, 2013
Kaitlin Shumate, Summer Research, University of Georgia, 2011
Evan Davidson, Summer Intern, St. Louis University 2008
Lindsay Oliva Stepp, Summer Intern, Indiana University 2008
Sarah Leung, Summer Intern, Arizona State University 2006, 2007
Greg Powell, Summer Intern, Catholic University 2006, 2007
Marwan Mustafa, Research Assistant, Molecular & Cell Biology, U of Arizona 2007
Alicia Newkirk, Research Assistant, Med Tech Program, University of Arizona 2002, 2004
Janelle Kennedy, Research Assistant, Molecular & Cell Biology, U of Arizona 2004
Keri Vartanian, Senior Honors Project, University of Arizona 2003
Niral Patel, Senior Honors Project Mentor, University of Arizona 2003
Jennifer Thompson, Research Assistant, Ecol & Evol Biology, U of Arizona 2002
Brian Constance, Research Project Advisor, Materials Sci and Eng, U of Arizona 2002
Joann Chang, Research Project Advisor, Mechanical Engineering, U of Arizona 2000-2001
Community School Teacher Mentoring
Jessica Minnich, Summer Institute Medical Ignorance, High School and Science Teacher Research
Fellow. 2002
Kris Yarter, Sabino High School AP Biology, High School Biology Teacher Summer Research
Hoying, James B January, 2016
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Program (NSF). 1999, 2000
PRESENTATIONS
Invited Talks
Invited Webinar speaker, Engineering a Functional Microcirculation, International Society of Applied
Cardiovascular Biology, ISACB Webinar Series, 2016.
Invited speaker, Tissue prevascularization, Department of BioEngineering, University of Pittsburgh,
Pittsburgh, PA, January 2016.
Invited speaker, The microvasculature as a therapeutic target, Department of Physiology, University of
Arizona, Tucson, AZ Sept. 2015
Invited speaker, Immune cell dynamics in white adipose tissue, Department of Microbiology &
Immunology, University of Louisville, Louisville KY April 2015.
Invited speaker, Manipulating the microvasculature and its environment, Experimental Biology,
Boston MA April 2015.
Invited speaker, Regulation of Angiogenesis/Collateral Artery Remodeling, Joint Meeting of the
Microcirculatory Society (MCS) and the North American Vascular Biology Organization
(NAVBO). Cape Cod, MA, Oct. 2013.
Invited speaker, Regenerative Angiogenesis Strategies, Cardiovascular Forum for Promoting Centers of
Excellence and Young Investigators, Louisville, KY, August 15-17, 2013.
Invited speaker, Formation of microvascular networks’ (role of stromal interactions directing
endothelial growth), The International Union of Physiological Sciences (IUPS) Congress,
Birmingham, UK, July 2013
Invited speaker, Microvascular Repair, Department of Biology, Bellarmine University, Louisville, KY,
April 2012
Invited speaker, Tissue perfusion during injury: quality not quantity, Kentucky Spinal Cord Injury
Research Center (KSCIRC), Louisville, KY, Feb. 2012
Selected speaker, Quantification of interactions of adipose derived stromal cells and the
microvasculature, IFATS Annual Conference. Miami FL, Nov. 2011
Invited speaker, Post-angiogenesis events in tissue neovascularization. Department of Physiology and
Biophysics, University of Louisville, KY, Sept. 2011
Keynote speaker, Engineering the microcirculation, Microvascularization for Tissue Engineering
Applications Symposium. TERMIS EU-2011 Annual Meeting, June 2011
Invited speaker, Engineering the coronary circulation. European Society of Cardiology conference.
Stockholm Sweden, Aug. 2010
Invited speaker, Reconstructing the microcirculation. Biomedical Engineering Program, University of
Hoying, James B January, 2016
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Arizona, Tucson AZ, Oct. 2009
Invited speaker, Reconstructing the microcirculation. Kentucky Spinal Cord Injury Research Center,
University of Louisville, KY, Mar. 2009
Invited speaker, Reconstructing the microcirculation. Texas A&M University, College Station, TX,
Feb. 2009.
Invited speaker, Microvascular Reconstruction: Discovery and Application. American Medical Writers
Association. 68th Annual National Conference. Louisville, KY, Oct. 2008
Invited speaker, Defining and reconstructing the microvasculature in revascularization. ANGIONET-
British Microcirculation Society Meeting, London, UK Feb. 2008
Invited speaker, Dynamics of Cell Interfaces BioInterface 2007, Surfaces in Biomaterials Conference.
San Mateo, CA, Oct. 2007
Invited speaker, Microvascular Remodeling. Meeting on Blood Flow in the Microcirculation: Function,
Regulation and Adaptation. Mathematical Bioscience Institute. Columbus, OH, Jan. 2007
Keynote speaker (open to the public), Tissue Engineering: A Vascular Perspective, Meeting on Blood
Flow in the Microcirculation: Function, Regulation and Adaptation. Mathematical Bioscience
Institute. Columbus, OH, Jan. 2007
Invited speaker, Biologically-based molecular detection devices, Bioengineering Platform Session,
Sixth Arizona Biosciences Leadership Symposium, Phoenix AZ, June 2006
Invited speaker: Genomic tools. Frontiers in Medicine Series, College of Medicine, University of
Arizona, Feb. 2006
Invited speaker, Microvessel maturation in the post-angiogenic microcirculation. International
Microcirculation Meeting, British Microcirculatory Society/The Microcirculatory Society, New
Hampshire, USA, Sep. 2005
Invited speaker: Endothelium. Frontiers in Medicine Series, College of Medicine, University of
Arizona, Apr. 2005
Invited speaker: Vessel Differentiation and Angiogenesis. Bi-annual Grover Conference on the
Pulmonary Circulation, Sep. 2004
Selected speaker: Genetic Programs in Angiogenesis. Symposium on Genomics of Angiogenesis and
Microcirculation, Experimental Biology meeting, San Diego, CA: Apr. 2003
Selected Poster presentation: Identification of Putative Vascular Genetic Circuits in Angiogenesis and
Vascularization. Program in Genomics Applications, National Heart, Lung, and Blood Institute
(NHLBI), National Institutes of Health, Bethesda, MD, July 2003
Invited speaker: Prevascularizing Tissue Constructs. Biomedical Engineering, University of Arizona,
Tucson, AZ, Apr. 2003
Invited speaker: Genetic Programs in Mammalian Vascularization. Vertebrate Development
Laboratory, National Institute of Childhood Health and Development (NICHD), National
Institutes of Health, Bethesda, MD, May 2003
Hoying, James B January, 2016
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Invited speaker: Understanding Biological Systems through Large-scale Gene Expression
Measurements, Sarver Heart Center, University of Arizona, Tucson, AZ, Nov. 2003
Invited speaker, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh,
PA, Nov. 2002
Invited speaker, Department of Physiology, University of Arizona, Tucson, AZ, Nov. 2002
Invited speaker, Department of Chemical and Environmental Engineering, University of Arizona,
Tucson, AZ, Nov. 2002
Invited speaker, “Mathematics and the Genome”, Mathematics Awareness Week, University of
Arizona, Tucson, AZ, April 2002
Invited speaker, Bioinformatics Symposium for Drug Development. University of Toledo, Toledo, OH,
Nov. 2001
Invited speaker, ASME Summer Bioengineering Conf. Snowbird, Utah, June 2001
Invited speaker, Department of Bioengineering, University of Utah, Salt Lake City UT, Feb. 2001
Invited speaker, Department of Pathology, Emory University, Atlanta, GA, March 2001
Invited speaker. Arizona Cancer Center, University of Arizona, Tucson, AZ, Nov. 1999
Selected poster presentation Gordon Research Conference on “Angiogenesis and Microcirculation”.,
August 1999
Invited speaker. Department of Pediatrics, University of Arizona, Tucson AZ, June 1999
Invited speaker. Annual AALAS meeting. Tucson AZ, June 1998
One of 4 New Investigators selected to represent the Cincinnati Program of Excellence at the annual
POE meeting held at NIH. Cardiovascular functions of FGF2, May 1998
Invited seminar speaker. Department of Physiology. Eastern Virginia Medical School. Norfolk, VA,
Jan. 1998
One of 2 New Investigators selected to represent the Cincinnati Program of Excellence at the annual
POE meeting held at MIT. Uncoupled stimulus-response in platelets lacking transforming
growth factor-β1, Nov. 1996
Selected speaker. Thrombosis section, American Heart Association Annual Meeting, Oct. 1996
Selected speaker. Bioengineering section, Annual FASEB meeting, April 1990
Public Media Presentations/Articles
Featured scientist, “Researchers to Watch”, Dawn Yankeelov, The Lane Report, 2015.
Invited Expert Panel Member, “Stem cell treatment: Revolutionizing medicine and society”, public
discussion event, National Stem Cell Foundation, 2015
Featured Segment, Fareed Zakaria’s GPS Moonshot series, 2014
Hoying, James B January, 2016
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Featured scientist, “3D bioprinter to reproduce human organs, change the face of healthcare: The inside
story”, Lindsey Gilpin and Jason Hiner, cover story, TechRepublic, 2014;
http://www.techrepublic.com/article/new-3d-bioprinter-to-reproduce-human-organs/
Invited guest panelist, The Heart Facts, Kentucky Health 360 television series, Kentucky Educational
Television (KET) Network, 2012
Feature article, Innovation in Cardiovascular Health. Courier-Journal Newspaper, Louisville, KY,
2009
Feature article, Positive Flow, Business First of Louisville, Louisville, KY, 2009
Abstracts (presented as either a poster or a talk)
Golway M and JB HOYING. Vascularized In vitro Perfusion Module (VIPM™) 3D Bio-printed with
the BioAssemblyBot™. Int. Soc. Applied Cardiovascular Biology (ISACB). 15th Biennial
meeting. Banff. 2016.
Candiello JE, Grandhi TSP, Dale J, Beare J, Rege K, Hoying JB HOYING, Kumta P, and Banerjee I.
Biomaterial Based Engineering of Vascularized Pancreatic Islet Organoids Derived from
Human Pluripotent Stem Cells (hPSCs). AICHe Conference 2016.
Stivers K, Dale J, Beare J, Chilton P, and JB HOYING. Tissue-resident myeloid-derived suppressor
cells in lean adipose. Research!Louisville 2015.
Edgar LT, JB HOYING, and Weiss JA. Predictions of Sprouting Angiogenesis within Heterogeneous
Extracellular Environments. BMES 2015.
Nevitt C, Grant, Katelyn, Jeff, Sarah, JB HOYING, and LeBlanc AJ. Physiological Levels of
Thrombospondin-1 Decrease NO-Dependent Vasodilation in Coronary Microvessels from Aged
Rats. Research!Louisville 2015.
Loganathan G, Ramakrishnan V, Boyd NL, Beare J, Tweed B, Kleinert L, Hughes MJ, JB HOYING,
Williams SK, Appakalai BN. Stimulation of intraislet endothelial cells to form peri-islet
capillaries (PIC’s) in human and rat islets: Role of adipose-derived stromal vascular fraction
(SVF) cells and ECGS solution. 2015 Joint Congress of the IPITA-IXA-CTS.
J.B. HOYING. Microvessel adaptation and plasticity in microvascular regeneration. GBC 2015.
Curtis-Whitchurch L, Dale J, Reed R, Doetschman T, and J.B. HOYING. Conditional deletion of the
planar cell polarity protein Vangl2 in vascular endothelial cells in mice. KY-APS 2015.
Ramakrishnan V.M., Yang JY, Tien KT, Maijub JG, Burchell PO, Bocard BR, Williams SK, Morris
ME, J.B. HOYING, Wade-Martins R, West FD, and Boyd NL. Generation of an Engineered,
Vascularized, iPSC-Derived Hepatic Module. TERMIS 2015.
Ramakrishnan V.M., Tien K.T., McKinley T.R., Bocard B.R., Williams S.K., J.B. HOYING, Boyd
N.L. Vascular Self-Assembly of Human Stromal Vascular Fraction Cells is Mediated by Wnt5a.
American Heart Association 2015.
Hoying, James B January, 2016
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Muradashvili N, Tyagi R, Dale JR, Benton RL, Tyagi SC, JB HOYING, and Lominadze D. Adipose
stromal vascular fraction cell treatment mitigates increased cerebrovascular permeability after
traumatic brain injury. National Neurotrama Society 2015.
Nevitt CD, Aird AL, JB HOYING, LeBlanc AJ. Age-related dysfunction in neovascularization
potential of adipose-derived stromal vascular fraction. AHA National Conference. 2014.
Muradashvili N, Tyagi R, Dale J, Benton RL, Tyagi SC, O’Toole TE, JB HOYING, Lominadze D.
Traumatic brain injury-induced increased pial venular permeability is ameliorated with
endothelial progenitor cells and the stromal vascular fraction cells in mice. AHA National
Conference. 2014.
Ramakrishnan VM, Burchell PO, Beier JI, Dale JR, Arteel GE, JB HOYING, Williams SK, and Boyd
NL. Adipose Stromal Vascular Fraction-Derived Vasculature Supports Implantation of
Parenchymal Hepatocytes. Research!Louisville 2013. Louisville, KY.
Touroo JS, JB HOYING, Williams SK. Macro and Micro Blood Vessel Mimics: In Vitro Models of
the Vascular System. Biointerface 2013. Minneapolis, MN.
Touroo JS, JB HOYING, Williams SK. Automated Encapsulation of Adipose Stromal Vascular
Fraction Cells in Alginate Hydrogel Spheroids Using a Direct-Write 3D Printing System.
IFATS 2013. New York, NY.
Hoying AM, Williams SK, and JB HOYING. Micro-physiological Assay for Angiogenesis. Kentucky
Innovation and Entrepeneurship Conference 2013. Lexington, KY.
JB HOYING. Post-Angiogenesis Network Architecture is not Pre-Determined in the Adult. Joint
Conference of the Microcirculatory Society and the British Microcirculatory Society. 2012.
Oxford, UK.
Ramakrishnan V.M., Maijub J.G., Morris M.E., J.B. HOYING, Williams S.K., and Boyd N.L.
Development of an engineered implantable vascularized cell-based LDL apheresis device.
Research!Louisville. 2012. Louisville, KY.
Krishnan L, JB HOYING, and Williams SK. Microvascular Angiogenesis and Maturation in the
Diabetic Microenvironment. Research!Louisville. 2011. Louisville, KY.
Kmetz D, Tinney JP, Dale J, Krishnan L, JB HOYING, and Keller BD. Characterization of Vascular
Maturation within Engineered Cardiovascular Tissues. Research!Louisville. 2011. Louisville,
KY.
Dale JR, Breite D, Clayton L, Dwulet F, McCarthy R, JB HOYING, and Williams SK. Impact of
Enzyme Composition on Adipose-derived Stromal Vascular Fraction Cell Isolation. IFATS
International Conference. 2011 Miami, Fl. (selected talk).
Krishnan L, Nunes SS, Chang CC, Williams SK, and JB HOYING. Stromal Vascular Fraction Cells
Potentiation Of Neovascularization Across Tissue Interfaces Is VEGF Dependent. IFATS
International Conference. 2011 Miami, Fl. (selected talk).
Krishnan L, Nunes SS, Williams SK, and JB HOYING. Quantification of Interactions of Adipose
Derived Stromal Cells and the Microvasculature. IFATS International Conference. 2011 Miami,
Fl. (selected talk).
Hoying, James B January, 2016
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LeBlanc AJ, JB HOYING, and Williams SK. Adipose Stromal Vascular Fraction Cells Preserve
Coronary Perfusion When Used Immediately After Ischemia. IFATS International Conference.
2011 Miami, Fl. (selected talk).
Boyd NL, Nunes SS, Krishnan L, Chang CC, Jokinen JD, and JB HOYING. Human embryonic stem
cell derived mesenchymal cells function as perivascular cells to stabilize endothelial networks
in three-dimensional collagen I constructs. Microcirculation Congress. 2010. Paris, France.
Nunes SS, Rekapally HR, Chang CC and JB HOYING. Vessel arterial/venous plasticity during adult
neovascularization. Microcirculation Congress. 2010. Paris, France.
Chang CC, Krishnan L, Reese S, Boland EB, Williams SK, and JB HOYING. In vitro patterned
microvessels lose alignment in vivo. Microcirculation Congress. 2010. Paris, France.
Leblanc AJ, HOYING JB, and SK Williams. Tissue-engineered cardiac patch stimulates angiogenesis
and improves coronary function after myocardial infarct. Microcirculation Congress. 2010.
Paris, France.
Boyd N, Nunes SS, Krishnan L, Chang CC, Jokinen JD, and JB HOYING. hESC derived
mesenchymal cells functionally stabilize HUVEC networks in 3D collagen I constructs.
Biomedical Engineering Society Annual Meeting. Austin TX. 2010.
Gruionu G, Galis Z, Secomb T, and JB HOYING. In Vivo Imaging of Microvascular Network
Development in a Tissue Engineered Construct. Biomedical Engineering Society Annual
Meeting. Austin TX. 2010.
Chang CC, Williams SK, Boland ED, and JB HOYING. Implanted Prepatterned Microvessel Patch
Develops Lumenized Networks within 1 week. Annual Hilton Head Workshop, "Regenerative
Medicine: Advancing to Next Generation Therapies" 2010. Hilton Head, SC. (selected talk).
Krishnan L, Chang CC, L Clayton, JB HOYING. Adipose derived stromal vascular fraction cells
potentiate neovascular sprout invasion of surrounding matrix. IFATS 2009. Daegu, S. Korea
(selected talk).
Krishnan L, U Utzinger, S Maas, S Reese, JA Weiss, S Williams, and JB HOYING. Extracellular
Matrix Stiffness Modulates Microvascular Morphology During Early Sprouting Angiogenesis
in Vitro. Proceedings of the ASME 2009 Summer Bioengineering Conference (SBC2009) June
17-21, Resort at Squaw Creek, Lake Tahoe, CA, USA. (selected talk).
Underwood C, L Krishnan, A Fung, S Reese, JB HOYING, and JA Weiss. Quantification of Temporal
Collagen and Microvessel Alignment Induced by Anchored Boundary Conditions During
Angiogenesis. Proceedings of the ASME 2009 Summer Bioengineering Conference (SBC2009)
June 17-21, Resort at Squaw Creek, Lake Tahoe, CA, USA. (selected talk).
Nunes SS, MA Maddie, RL Benton, JB HOYING. Angiogenic potential of isolated microvessel
fragments is independent of their tissue origin. FASEB J. 2009 23:592.9. (selected talk).
Krishnan L, CC Chang, SK Williams, and JB HOYING. Role of insulin and hyperglycemia in
angiogenic sprouting and microvessel survival. FASEB J. 2009 23:592.4.
Rekapally H, CM Stiening, and JB HOYING.Alignment-dependent regulation of vangl2, a planar cell
polarity core member, in adult endothelial cells. FASEB J. 2009 23:767.2.
Hoying, James B January, 2016
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Boyd NL, SS Nunes, JB HOYING, and SL Stice. α-Smooth Muscle Actin Differential Regulation in
Human Embryonic Stem Cell Derived Mesenchymal Cells. FASEB J. 2009 23:1030.2.
Chang CC and. In Vitro Perfused Microvessel Networks. Cardiovascular Pathology. 17(4):268.
September. 2008. Bordeaux, France. (selected talk).
Z Rivera, JB HOYING, and PB Hoyer. Residual ovarian tissue of follicle-depleted mice expresses
genes for androgen synthesis and metabolism of xenobiotic compounds. Society for the Study
of Reproduction. May. 2008. Kona, HI.
Z Rivera, JB HOYING, PB Hoyer. Enriched expression of lipid biosynthetic genes in follicle-depleted
mouse ovaries depleted mouse ovaries. FASEB J. March. 2008. 22:1188.10. San Francisco, CA.
CJ Underwood, L Krishnan, N Kirkpatrick, W Brands, U Utzinger, JE Guilkey, JA Weiss, JB HOYING.
Biomechanical Interactions of Angiogenic Microvessels with the Extracellular Matrix. Trans-
Institute Angiogenesis Research Program Bi-annual Meeting. November. 2007. Bethesda, MD.
L Krishnan, CJ Underwood, SA Maas, B Ellis, TC Kode, JB HOYING, JA Weiss. Microvascular
orientation during angiogenesis: effects of mechanical stretch and boundary conditions
Proceedings of the ASME 2007 Summer Bioengineering Conference. July. 2007. Orlando, FL.
TR Cardinal and JB HOYING. A modified fluorescent microsphere-based approach for determining
resting and hyperemic blood flows in individual murine skeletal muscles. Mathematical
Bioscience Institute Workshop. January. 2007. Columbus, OH.
TR Cardinal, CJ Sullivan, and JB HOYING. Targeted disruption of Fgf2 impairs blood flow control in
the posterior gracilis during revascularization. FASEB J. 20:LB9. 2006.
RP Rhoads, X Ling, TR Cardinal, S Sheehan, M Morales, R Chetham, JB HOYING, and R Allen.
Aging impairs the ability of satellite cells to induce angiogenesis in vitro. FASEB J. 20:LB34.
2006.
AM Hiscox, AL Stone, G Gruionu, EB Patula, JB HOYING, and SK Williams. Development of an
islet-stabilizing implant construct. FASEB J. 20:A299. 2006.
CM Stiening, MB Abdallah, JB HOYING, and RJ Collier. Effect of lactogenic stimuli and serotonin
on secretory activation of bovine mammary epithelial cells (BMEC). FASEB J. 20:A616. 2006.
G Gruionu, JB HOYING, and TW Secomb. Increased arterial wall volume following chronic
reduction of blood flow. FASEB J. 20:A710. 2006.
CC Chang and Hoying JB. Patterned 3-D growth of microvessels. FASEB J. 19:A158. 2005.
CA Smith, Warren WL, Hoying JB, and Williams SK. Utilizing a three-dimensional bioassembly tool
to fabricate spatially organized multicellular vascular constructs. FASEB J. 19:A160. 2005.
C Stiening, Hoying J, and Collier R. Profiling gene expression during mammary epithelial cell
differentiation. FASEB J. 19:A1004. 2005.
TR Cardinal, Sullivan CJ, and Hoying JB. A fluorescent microsphere-based method for assessing
regional blood flows in the mouse hindlimb. FASEB J. 19:A1270. 2005.
JE Guilkey JE, Hoying JB, and Weiss JA. Large-scale modeling of the mechanical behavior of
Hoying, James B January, 2016
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multicellular constructs. ASME Bioengineering Conference. 2005.
G Gruionu, Stone AL, Hiscox A, Williams SK, Hoying JB. The effects of pancreatic islets on a tissue
engineered microvascular network. BMES Conference. 2005.
S Powis, Hoying JB, Riley MR, and Williams SK. Acquired microbial resistance to chlorine dioxide.
Antimicrobial Resistance conference sponsored by the National Foundation for Infectious
Diseases. 2005. (selected talk).
SK Beck, Chen HYS, Greer KA, Schwartz MA, Hoying JB. Complex activities of Wnt/Frizzled
signaling in microvascular maturation. FASEB J. 19(4): A163, 2005.
TR Cardinal, Sullivan CJ, Hoying JB. A fluorescent microsphere-based method for assessing regional
blood flows in the mouse hindlimb. FASEB J. 19(5): A1270, 2005.
CM Stiening, Abdallah MB, Greer K, Hoying A, Hoying J, Collier R.J Profiling Gene Expression
During Mammary Epithelial Cell Differentiation. FASEB J. 19(5): A1005, 2005.
G Gruionu, JB HOYING, MH Laughlin, GM Constantinescu, LG Gruionu, and TW Secomb.
Simulation of blood flow and structural adaptation in arteriolar arcade network of miniature
swine triceps muscle: Maintenance of perfusion following partial removal of blood supply.
FASEB J. 18(5): A255, 2004.
MA Schwartz, AL Stone, KA Greer, SK Williams, and JB HOYING. Using gene expression profiles
to determine the role of laminin 5 modification in polymer associated healing. FASEB J. 18(5):
A759, 2004.
KR Kidd, KA Greer, JB HOYING, and BM Weinstein. Molecular analysis of arterial-venous
differentiation using oligonucleotide microarray technology in the zebrafish. FASEB J. 18(5):
A776, 2004.
MR Reynolds, KM Taylor-Barcia, KA Greer, JB HOYING, and HL Brooks. Analysis of inner
medullary collecting duct gene expression in AQP1KO mice. FASEB J. 18(5): A1021, 2004.
Y Zhang, JE.Guilkey, JB HOYING, and JA.Weiss. Mechanical simulation of multicellular structures
with the material point method. 6th International Symposium on Computer Methods in
Biomechanics and Biomedical Engineering.
CS Weber, JB HOYING and RM Lynch. Capacitative Ca2+ influx is enhanced in aortic endothelial
cells from sarco-(endo)plasmic reticulum Ca2+ATPase isoform 3 knockout mice. FASEB J.
17(4): A43, 2003.
HYS. Chen, CS Weber, RM Lynch, and JB HOYING Altered regulation of calcium handling proteins
in endothelial cells of the Sarco-(endo)plasmic Reticulum Ca2+ATPase Isoform 3 Knockout
Mouse. FASEB J. 17(4): A43, 2003.
AM Hoying, KA Greer, MA Schwartz, JB HOYING and SE Klewer. High Quality, High Density,
Low Cost Fabrication of cDNA and Oligo Glass Microarrays. FASEB J. 17(4): A77, 2003.
KA Greer and JB HOYING Implementation of a Statistical Linear Model for Microarray Data
Analysis. FASEB J. 17(4): A78, 2003.
CJ Sullivan, KA. Greer, JB HOYING differential gene expression in the ischemic hindlimb in the
Hoying, James B January, 2016
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absence of FGF2. FASEB J. 17(4): A78, 2003.
MA Schwartz, AL. Stone, KA. Greer, KR. Kidd, SK. Williams, JB. Hoying. Evidence for a Cyclical
Nature in Chronic Healing Response Associated with Artificial Device Implantation using Gene
Expression Analysis. FASEB J. 17(4): A81, 2003.
I. Jongewaard, KA Greer, A Person, K Pogreba-Brown, JB HOYING, P Antin, R Runyan, and S
Klewer. Genes profiling of the developing chicken cardiovascular system using DNA
microarray and novel computational algorithms. FASEB J. 17(4): A158, 2003.
MR. McReynolds, KA. Greer, AM. Hoying, MA. Schwartz, JB HOYING and HL Brooks. Effects of
Dehydration on Gene Expression: A cDNA Array Study in Mouse Renal Medulla. FASEB J.
17(4): A482, 2003.
KR. Kidd, HYS Chen, KA. Greer, MA Schwartz, JB HOYING. Tissue vascularization is associated
with distinct vascular gene expression patterns. FASEB J. 17(4): A500, 2003.
CM. Smith, HYS Chen, J Rodriquez, J Barton, and JB HOYING. Three dimensional analysis of mural
cell coverage in microvascular collagen gels. FASEB J. 17(4): A500, 2003.
BR Shepherd, JB HOYING, SK Williams. Implantation of a tissue engineered microvascular graft
reduces infarct size in a murine model of myocardial infarction. FASEB J. 17(4): A500, 2003.
KB. Vartanian, HY.S. Song, KR. Kidd, H Wang and JB HOYING. Acceleration of angiogenesis in
microvessel treated with thrombin TP508. FASEB J. 17(4): A501, 2003.
G Gruionu, TW Secomb, and JB HOYING. Spatial and temporal heterogeneity during structural
remodeling of the mouse gracilis artery. FASEB J. 17(4): A551, 2003.
JA Szivek, MM Fernandez, WA Grana, DS Margolis, F Blumenkron, PD Calvert, PP Bourque, R
Vaidyanathan, and JB HOYING. Preliminary tissue engineering studies of cartilage and bone
on PBT scaffolds. Annual meeting of the Surfaces in Biomaterials Foundation. BioInterfaces
1:20. 2002.
L Krishnan, JA Weiss, MD Wessman, JB HOYING, R Das. Viscoelastic characterization of collagen
gel constructs. 4th World Congress of Biomechanics, Calgary, CA, July 2002.
L Krishnan, H Song H, JB HOYING, R Das, JA Weiss. Angiogenesis alters the material properties of
the extracellular matrix. Submitted, 49th Annual meeting of the Orthopaedic Research Society,
July 2002.
R Das, L Krishnan, C Evensen, JB HOYING, JA Weiss. Alterations in angiogenesis- and ECM-related
gene expression following partial medial collateral ligament injury. Submitted, 49th Annual
meeting of the Orthopaedic Research Society, July 2002.
JB HOYING, Helen Y.S. Chen, Benjamin Shepherd, and Stuart K. Williams. Rapid perfusion of a
prevascularized tissue construct following implantation. Cardiovascular Pathology. 11(1):47.
2002.
Schwartz MA, A Stone, SK Williams, and JB HOYING. Angiogenesis-related gene expression during
healing associated with polymer implants. Cardiovascular Pathology. 11(1):59. 2002
CJ Sullivan and JB HOYING. FGF2 is not essential during flow-dependent arterial remodeling in the
Hoying, James B January, 2016
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mouse. Cardiovascular Pathology. 11(1):18. 2002.
G Gruionu, TW Secomb, and JB HOYING. Structural Remodeling of the Murine Gracilis Muscle
Vasculature Following Permanent Interruption of Blood Supply. Cardiovascular Pathology.
11(1):44. 2002.
Greer K and JB HOYING. A comparison of hierarchical clustering algorithms on simulated
microarray data. The Physiologist 45(1):67. 2002.
Schwartz MA and JB HOYING. Describing angiogenesis phenotypes at the gene expression level
using cDNA microarrays. The Physiologist 45(1):76. 2002.
CJ Temm-Grove, JB HOYING, and DJ Hartshorne. Pericyte protein expression when activated
through the Rho signaling pathway. Keystone in Angiogenesis. 2001.
H Wang, M Schwartz, J Convery, JB HOYING, and JT Ryaby. Tp508, a synthetic thrombin peptide,
activates angiogenesis-related genes during femoral fracture healing. Frontiers of Skeletal
Biology. 2001.
Weber, C.S., JB HOYING, and RM Lynch. Altered Ca+2 homeostasis in aortic endothelial cells from
Sarco(endo)plasmic reticulum Ca+2 ATPase isoform 3 (SERCA3) knockout mice. FASEBJ.
15(5):A1117. 2001.
Sullivan C.J. and JB HOYING. Flow-dependent outward and inward arterial remodeling in the mouse.
FASEB J. 15(5):A950. 2001.
Shepherd B.R., JB HOYING, and SK Williams. Blood perfusion through a prevascularized tissue
construct following transplantation. FASEB J. 15(4):A116. 2001.
Budoff A, Greer K, Constance B and JB HOYING. Transcription profiling of angiogenesis using
DNA microarrays. Cardiovasc. Pathol. 9(4):234. 2000.
Gunatilaka T and JB HOYING. Screening for genes uniquely expressed by angiogenic microvessels
using DNA microarrays. Cardiovasc. Pathol. 9(4):235. 2000.
Gruoinu G., Sullivan CJ and JB HOYING. Mapping revascularization of the murine ischemic
hindlimb. FASEB J. 14(4):A35. 2000.
Sullivan C.J. and JB HOYING. Endogenous fibroblast growth factor-2 (FGF2) is not required for
ischemia-induced angiogenesis. FASEB J. 14(4):A35. 2000.
Sutliff, R.L., JB HOYING, V.J. Kadambi, E.G. Kranias, and R.J. Paul. Functional and biochemical
evidence for modulation of endothelial cell function by phospholamban. FASEBJ.
12(5):A957.1998.
HOYING JB, M. Yin, and T. Doetschman. Faulty IIb/3 activation in platelets from transforming
growth factor1- deficient mice. FASEB J. 11(9):A1168. 1997.
HOYING JB, M. Zhou, T. Doetschman, and C. Haudenschild. Comparison of vascular injury/repair
between FGF2 wild type and knockout mice. Microcirculation. 4(1):186.1997.
HOYING JB, M. Yin, and T. Doetschman. Abnormal platelet function in TGF1-deficient mice.
Circulation 94(8):I-580.1996.
Hoying, James B January, 2016
30
HOYING JB and S.K. Williams. Measurement of endothelial cell migration using a linear migration
assay. FASEB J. 9(4):A645.1995.
HOYING JB and S.K. Williams. Reduced adhesion of human microvascular endothelial cells to
collagen I in response to basic fibroblast growth factor is mediated byβ1 integrin. FASEB J.
8(4):A45.1994.
HOYING JB and S.K. Williams. Differential effects of growth factors on in vitro angiogenesis in 3-
dimensional culture. FASEB J. 8(5):A1044.1994.
HOYING JB and S.K. Williams. Growth of freshly isolated microvessel fragments cultured within
collagen I gels. FASEB J. 7(3):A126.1993.
Chen, S-C., JB HOYING, and S.K. Williams. Diffusion rates of solutes in extracellular matrix
measured by fluorescence recovery after photobleaching. Mol. Biol. Cell 3:228a.1992.
HOYING JB and S.K. Williams. Differential responses of endothelial cells to tumor necrosis factor-
alpha. FASEB J. 3(4):A526.1991.
HOYING JB and S.K. Williams. Examination of endothelial cell monolayer permeability by total
internal reflection fluorescence microscopy. FASEB J 4(3):A415.1990.
HOYING JB, T.S. Schneider and S.K. Williams. Evaluation of gold labeled glucosylated albumin
transport across endothelial cell monolayers using rapid freeze fixation. J. Cell Biology.
109(4):203a.1989.
PATENTS AND DISCLOSURES
Issued Patents
US # 8,727,965, Methods and Compositions to Support Tissue Integration and Inosculation of
Transplanted Tissue and Transplanted Engineered Penile Tissue with Adipose Stromal Cells.
12/2015
US #12/562,832, Bioreactors, systems, and methods for vascularizing tissue constructs. 8/2015
US #7,862,652, Directional self-assembly of biological electrical interconnects. 1/2011
US #7,052,829, Prevascularized constructs for implantation to provide blood perfusion. 5/2006
US #7,029,838, Prevascularized constructs for implantation to provide blood perfusion. 4/2006
Pending/Provisional Patent Applications
US #61/818,294 Compositions and methods for treatment of vessel disease
US #14/426,618 Cell systems and methods for delivering disease-specific therapies
US #61/370,714 Prevascularized materials and methods of using the same
Hoying, James B January, 2016
31
US #61/449,390 Encapsulation and delivery systems for biological suspensions and methods of
making the same
US #20100196433 Prevascularized devices and related methods.
US #20100075293 Bioreactors, systems, and methods for vascularizing tissue constructs.
US #20090017553 Immunoassay-based microsensing using optical sensors
GRANTS AND CONTRACTS
Active
R01 HL131856-A1 (PI) 1/1/17 to 12/31/22
NIH/HLBI $1,250,000
Neovessel guidance in angiogenesis 20% effort
The major goal of this project is to define the interplay between biomechanical forces and angiogenic
factor signaling in guiding neovessel growth during angiogenesis. Recently scored 5%
R01 (Co-I; LeBlanc PI) 4/1/17 to 3/31/22
NIH/HLBI $1,886,659
Mechanisms of Cell Therapy to Improve Coronary Microvascular 10% effort
Dysfunction in Aging
The major goal of this project is to explore the dynamics of a cell-based therapy for myocardial
ischemia in the context of aging. Recently scored 4%
JHFE (Co-PI; LeBlanc, PI) 9/1/16 – 8/31/18
Microvascular Dysfunction in Women’s Hearts: A Novel Diagnosis $300,000
and Treatment Regime The major goal of this project is to develop a new diagnostic and cell-based therapy for microvascular
angina
MR120023P2 (Co-PI) 09/30/13 – 10/01/17
Department of Defense, Restorative Transplantation $1,777,421
Research Program 8% effort
Positioning Vascularized Composite Allotransplantation within the Spectrum of Transplantation
The goal of this project is to assess vasculopathies in vascularized tissue/organ transplants.
AFIRMII-CTA-09 (Co-PI) 07/01/2013 – 06/30/2018
US Army Medical Research and Materiel Command $824,354
Tolerization of Vascularized Composite Allografts 8% effort
The goal of this project is to assess adipose regenerative cell therapies in vascularized tissue/organ
transplant patients.
R21 (Co-I; Boyd PI) 4/1/16 to 3/31/18
NIH/HLBI $275,000
Hoying, James B January, 2016
32
Patient Specific Hepato-Vascular Unit for LDL Clearance 5% effort
The major goal of this project is to develop a biologically-based apheresis system to treat familial
hypercholesterolemia.
P30 GM103507 (Core Director) 4/1/11 - 7/31/16
NIH/NCRR $1,123,125
Mechanisms of plasticity and repair after SCI 10% effort
This support expands the Core facilities and pilot grants program to the existing COBRE
Helmsley Charitable Trust Foundation (Core Director & project Co-I; Harkema PI) 1/1/16 – 12/31/19
Kentucky Spinal Cord Research Center $15,000,000
The Helmsley Center for Restorative Medicine: An Interdisciplinary, 5% effort
Collaborative Program in Medical Research for Spinal Cord Injury
This supports the Microscopy and Functional Imaging Core of KSCIRC/CII and vascular assessment of
spinal cord injury in a rat model.
Pending
1T32HL134644-01A1 (Mentor) 7/1/2017 to 6/30/2022
NIH/NIGMS $1,486,242
Current Trends in Stem Cell Therapies
The intent of this program is to provide focused post-doctoral training in the biology and application of
cell-based therapies.
1T32HL134627-01 (Mentor) 09/01/2016 to 08/31/2021
Title: Cardiovascular Sciences $1,546,492
The intent of this program is to provide focused pre-doctoral training in cardiovascular health and
disease.
1R25GM123933-01 (Mentor) 07/01/17 to 06/30/22
NIH $1,486,242
Bridge to Undergraduate Success (BUS)
The intent of this program is to provide biomedical research exposure to under-served undergraduate
students.
1T32 (Mentor) 09/01/16 to 08/31/21
NIH $945,636
Inflammation and Pathogenesis
The intent of this program is to provide focused pre-doctoral training in tissue injury and inflammation.
AHA Pre-doctoral Fellowship Curtis-Whitchurch (Sponsor) 7/1/2016 to 6/30/2020
Vangl2 as an organizer of membrane lipid rafts in endothelial cell signaling
Hoying, James B January, 2016
33
R21 (Co-I; LeBlanc PI) 9/1/16 to 8/31/18
NIH/ASG $275,000
Reversing microvascular dysfunction in aging hearts 10% effort
The major goal of this project is to develop an intravenous, cell-based therapy to reverse coronary
microvascular dysfunction in aging, female hearts. in review.
R01 (Co-l; Boyd PI) 7/1/16 to 6/30/21
NIH/NIDDK $2,384,892
Patient Specific Hepato-Vascular Unit for LDL Clearance 5% effort
The major goal of this project is to develop a biologically-based apheresis system to treat familial
hypercholesterolemia. Revision in review
Research Accelerator Award (PI – sub; Banerjee U Pitt PI) 1/1/17 to 12/31/21
American Diabetes Association 3% effort
Engineering islet organoids with islet-specific vasculatures $200,000 (sub)
The major goal of this project is to incorporate a vasculature into iPSC-derived islet cell organoids that
support islet-like function.
Hoying, James B January, 2016
34
Completed
VV Cooke Foundation 12/01/15 – 11/30/16
Pilot Program $10,000
Studies in Women’s Heart Health 2% effort
The goal is to perform pilot studies in support of a pre-clinical investigation of cell therapy for
microvascular angina.
Kosair Charities (PI) 11/01/12 – 12/31/15
Christine Kleinert Institute $280,000
Basic Science Studies to increase safety of transplantation 5% effort
The goal of this project is to investigate the ability of adipose regenerative cells to modulate immune
responses to vascularized tissue/organ transplant.
R01 DK078175 (Co-PI) 12/1/2007 to 11/30/2012-NCE
NIH/NIDDK $1,000,500
A Prevascularized Islet Immune-isolation Device 10% Effort
The goal of this project is to develop a prevascularized implantable device to support islet viability and
function.
R01 HL077683 (PI subcontract) 7/1/08 to 6/30/12 - NCE
NIH/NIBIB $540,000
Angiogenesis and the Extracellular Matrix 8% effort
The major goal of this project is to define the microscale biomechanical interactions of angiogenic
microvessels with the extracellular matrix (ECM) in order to develop a computational model of
angiogenesis.
R01EB007556-01 (PI) 7/1/07 to 6/30/11
NIH/NIBIB $3,000,000
Fabrication of Microvascular Tissue Fabrics 15% Effort
The goal of this project is to generate pre-patterned, two and three dimensional microvascular networks
capable of functioning as a blood perfusion system.
R01 HL099014 (Collaborator) 2/1/10 – 1/31/14
NIH/NHLBI $372,000 annual
Role of Glutathione S-Transferase P in Heart Failure 5% effort
The primary goal of this project is to define the mechanisms of GSTP-mediated heart failure.
[This grant transferred with Dr. Prabhu when he relocated to another University]
R41HL115849-01A1 (PI, Angiomics Inc.) 4/01/13 – 12/31/14
NIH/NHLBI $100,000
human Microvessel Culture System (hMCS) 10% effort
This project entails the development of a 3-D human-based in vitro angiogenesis assay for therapeutics
screening.
Hoying, James B January, 2016
35
#COMMFUND-1400-RFP-014 (PI) 2/1/13 – 1/31/14
Kentucky Science and Engineering Foundation (KSEF) $75,000
Adipose Regenerative Cell Isolation System
This project is to develop an isolation kit of adipose regenerative cells for commercialization.
(PI subaward)
(PI) 10/1/11 – 9/30/13
Kosair Pilot Grant Program $50,000
Role of Vangl2 in Vascular Formation 5% effort
This is a pilot project developing exploratory data, including a conditional targeted knockout mouse of
Vangl2.
IRIG Pilot Grant Program (PI) 1/1/13 – 12/31/14
U of L VPR Office $5,000
Epigenetic Regulation of Adult Neovascularization and Vascular Stability
Generate pilot data in the investigation of epigenetic control of vascular maturation.
(PI subcontract) 7/1/10 - 10/30/14 (NCE)
James S. McDonnell Foundation $168,000
Architecture-dependent Signaling in Multicellular Networks 5% effort
The goal is to perform a combined experimental and theoretical study of calcium signaling in networks
of endothelial cells as prototypical models of complex architectures.
(Collaborator) 6/1/10 - 5/31/11 U. of Louisville Research Foundation $15,000
Role of estriol in placental vascularization during preeclampsia 2% effort
This project will evaluate effects of estriol on placental vascularization using both human tissue and a
mouse model of preeclampsia.
OICN081473 (Collaborator) 8/1/08 to 7/31/09
Abiomed, Inc. $561,060
Abiomed VAD Benchmark Trial 10% effort
The major goal of this project is to develop a panel of performance benchmarks and standards for the
clinical implementation of Abiomed ventricular assist devices.
0755710Z (PI) 7/1/07 to 6/30/10
AHA-Pacific Mountain Affiliate $66,000 annual
Wnt/Planar Cell Polarity Signaling in Post-angiogenesis
Microvascular Maturation
The major goal of this project is to define the role planar cell polarity plays in the maturation of new
vessels formed following angiogenesis.
06-027, (PI) 7/1/06 to 6/30/09
Arizona BioResearch Commission $50,000 annual
Hoying, James B January, 2016
36
Gene Markers of Angiogenesis and the Microcirculation
The major goal of this project is to determine gene expression programs in vascular cells associated
with specific events in vascularization in mouse and human.
R01 HL077683, (PI subcontract) 1/1/04 to 12/31/08
NIH/NIBIB $165,000 annual
Angiogenesis and the Extracellular Matrix
The major goal of this project was to develop advanced modeling and imaging methods to determine
the effects of biomechanical conditioning on the angiogenesis process.
ECS 0303863, (Co-PI) 8/1/03 to 7/31/07
NSF/NIRT $250,000 annual
Reversible and Directed Self-Assembly of Bio-Molecular Templates for Nanotechnology Interconnects
The major goal of this project was to fabricate nano-scale, multi-dimensional, conductive, interconnects
using microtubules.
Juvenile Diabetes Research Foundation, (PI) 10/1/05 to 9/30/06
Microvascular Maturation in Diabetes $100,000
The major goal of the project was to characterize microvascular maturation in the normal and
hyperglycemic environment in the absence and presence of pancreatic islets
K02 HL67067, (PI) 8/1/01 to 7/31/06
NIH/NHLBI $76,000 annual
SERCA3 in Vascular Physiology
The major goal of this award is to develop Dr. Hoying’s research career in vascular biology. Includes
support for expanded research activities beyond currently funded projects.
R01 HL63732, (PI) 2/1/00 to 1/31/05
NIH/NHLBI $159,000 annual
Specificity in endothelial cell calcium signaling
The major goal of this project was to determine the role of SERCA3-managed calcium in endothelial
cell biology.
R01 HL63873, (Co-I) 11/1/00 to 7/31/05
NIH/NHLBI $200,000 annual
Role of Laminin-5 in Implant Associated Angiogenesis
The major goal of this project was to examine the angiogenesis and neovascularization of polymers
modified with the major extracellular matrix proteins involved in microvascular homeostasis as
compared to laminin 5.
Role: Co-Investigator
R01 EB000660, (Collaborator) 9/30/02 to 9/29/06
NIH/NIBIB $182,000 annual
Sensate Scaffold for Orthopedic Tissue Repair
Hoying, James B January, 2016
37
The major goal of this project is to develop an implantable sensate scaffolds in vivo for monitoring of
bone loading.
Role: Co-Investigator
UofA Children Research Center (Co-PI) 7/1/04 to 6/30/05
Treatment of Type 1 Diabetes through Beta-Cell Replacement Therapy $100,000
The goal of this project is to test the hypothesis that the combination of a stable, pre-formed
microvasculature and vascular-compatible, immuno-isolation devices will lead to successful
implantation of ß-cell constructs.
Orthologic, Inc. (PI) 7/25/04 to 5/31/06
Angiogenic Potential of the Thrombin non-PAR analog, TP-508 $65,000 total
The goal of this project was to evaluate the angiogenic potential of the non-PAR agonist TP508 in vivo.
The Aircast Foundation, Inc., Collaborator: (Co-I) 12/00 to12/02
Effect of Anti-angiogenic Treatment on Ligament Healing $200,000
The goal of this project was to investigate the role angiogenesis plays in ligament healing emphasizing
the effects on ligament biomechanics. This project provided preliminary data for the currently active
R01 on angiogenesis and biomechanics.
HRSA, Equipment Grant, (Core Director) 9/02-8/03
Microarray Core Facility $984,488
An equipment grant to provide a proteomics-based discovery tool for the microarray core facility.
BES-9978820, (Consultant) 8/99 to 7/02
NSF $101,923
Vascular Characterization with OCT Techniques
The goal of this project was to examine a number of different vascular settings (microvascular and
macrovascular) with a new endoscopic optical coherence tomography system.
Role: Co-Investigator
NIH/HLBI, T32 HL07955 (Co-I) 7/1/05 to 6/30/10
Graduate Training in Cardiovascular Biomedical Engineering $292, 000 annual
Role: Mentor/Steering Committee
NIH/NIBIB, T32 EB000809, Mentor 5/1/03 to 4/30/08
Graduate Training in Biomedical Imaging and Spectroscopy $302,640 annual
Role: Mentor
NIH/HLBI, T32 HL07249, Mentor/Steering Committee 6/1/02 to 5/31/07
Training in Cardiovascular Systems Physiology $143,750 annual
Role: Mentor
NIH/NIGMS, T32 GM08400-15, Mentor 7/1/02 to 6/30/07
Hoying, James B January, 2016
38
Graduate Training in Systems and Integrative Physiology $187, 680 annual
Role: Mentor
PUBLICATIONS:
Published Articles- Peer Reviewed
1. Nevitt C, McKenzie G, Christian K, Austin J, Hencke S, Hoying J, and LeBlanc A. Physiological
levels of thrombospondin-1 decrease NO-dependent vasodilation in coronary microvessels from
aged rats. Am J Physiol Heart Circ Physiol 310: H1842-1850, 2016.
2. Sun J, Hoying JB, Deymier PA, Zhang DD, and Wong PK. Cellular Architecture Regulates
Collective Calcium Signaling and Cell Contractility. PLoS Comput Biol 12: e1004955, 2016.
3. Kaufman CL, Marvin MR, Chilton PM, Hoying JB, Williams SK, Tien H, Ozyurekoglu T, Ouseph
R. Immunobiology in VCA. Transplant international: official journal of the European Society for
Organ Transplantation. 2016
4. Ramakrishnan VM, Tien KT, McKinley TR, Bocard BR, McCurry TM, Williams SK, Hoying JB,
Boyd NL. Wnt5a regulates the assembly of human adipose derived stromal vascular fraction-
derived microvasculatures. PLoS One. 2016;11:e0151402
5. LeBlanc AJ, Hoying JB. Adaptation of the Coronary Microcirculation in Aging. Microcirculation
(New York, NY : 1994). 2016;23(2):157-67.
6. Xu J, Zheng S, Kralik PM, Krishnan L, Huang H, Hoying JB, Cai L, Carlson EC, Tan Y, Epstein
PN. Diabetes Induced Changes in Podocyte Morphology and Gene Expression Evaluated Using
GFP Transgenic Podocytes. International journal of biological sciences. 2016;12(2):210-8.
7. Deymier PA, Swinteck N, Runge K, Deymier-Black A, Hoying JB. Effect of sound on gap-
junction-based intercellular signaling: Calcium waves under acoustic irradiation. Phys Rev E Stat
Nonlin Soft Matter Phys. 2015;92:052711
8. Gabbur P, Hoying J and Barnard K. Multimodal probabilistic generative models for time-course
gene expression data and Gene Ontology (GO) tags. Math Biosci. 2015 268:80-91
9. Maijub JG, Boyd NL, Dale JR, Hoying JB, Morris ME, and Williams SK. Concentration Dependent
Vascularization of Adipose Stromal Vascular Fraction Cells. Cell Transplant. 2015 24:2029-39.
10. Ramakrishnan VM, Yang JY, Tien KT, McKinley TR, Bocard BR, Maijub JG, Burchell PO,
Williams SK, Morris ME, Hoying JB, Wade-Martins R, West FD and Boyd NL. Restoration of
Physiologically Responsive Low-Density Lipoprotein Receptor-Mediated Endocytosis in
Genetically Deficient Induced Pluripotent Stem Cells. Scientific Reports. 2015 5:13231.
11. Edgar LT, Hoying JB and Weiss JA. In Silico Investigation of Angiogenesis with Growth and
Stress Generation Coupled to Local Extracellular Matrix Density. Ann Biomed Eng. 2015 43:1531-
42.
12. Utzinger U, Baggett B, Weiss JA, Hoying JB. Gigavoxel Time-lapse Microscopy of Angiogenic
Hoying, James B January, 2016
39
Sprouting. Angiogenesis. 2015 18(3):219-32 (selected for cover image).
13. Morris ME, Beare JE, Reed RM, Dale JR, LeBlanc AJ, Kaufman CL, Zheng H, Ng CK, Williams
SK, and Hoying JB. Systemically-delivered adipose stromal vascular fraction cells disseminate to
peripheral artery walls and reduce vasomotor tone through a CD11b+-cell-dependent mechanism.
Stem Cells Trans Med. 2015 Stem Cell Trans Med. 2014-0252.
14. Aird AL, Nevitt CD, Christian K, Williams SK, Hoying JB, and LeBlanc AJ. Adipose-derived
stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the
formation of microvascular networks. Exp Gerontol. 2015 Jan 21;63C:18-26
15. Hoying JB, Utzinger U, and Weiss JA. Formation of microvascular networks: role of stromal
interactions directing endothelial growth. Microcirculation. 2014 (4):278-89 invited review.
16. Underwood CJ, Edgar LT, Hoying JB, and Weiss JA. Cell-generated Traction Forces and the
Resulting Matrix Deformation modulate Microvascular Alignment and Growth during
Angiogenesis. Am J Physiol Heart Circ Physiol. 2014, 307(2):H152-64. Editor’s Pick.
17. Edgar LT, Hoying JB, Utzinger U, Underwood CJ, Krishnan L, Baggett BK, Maas SA, Guilkey JE,
and Weiss JA. Mechanical Interaction of Angiogenic Microvessels with the Extracellular Matrix. J
Biomech Eng. 2014 (2):021001. invited review.
18. Edgar LT, Underwood CJ, Guilkey JE, Hoying JB, and Weiss JA. Extracellular Matrix Density
Regulates the Rate of Neovessel Growth and Branching in Sprouting Angiogenesis. PLoS One
2014 9(1):e85178.
19. Krishnan L, Touroo J, Reed R, Boland E, Hoying JB, Williams SK. Vascularization and cellular
isolation potential of a novel electrospun cell delivery vehicle. J Biomed Mater Res A. 2014
102(7):2208-19
20. Long J, Deymier PA, Runge K, Hoying JB. Regulation of the frequency and wavelength of calcium
waves propagating in networks of interconnected cells: A simulation study. Trends in Cell &
Molecular Biology. 2014;9:19-33.
21. Krishnan L, Chang CC, Nunes SS, Williams SK, Weiss JA, and Hoying JB. Manipulating the
Microvasculature and its Microenvironment. Crit Rev Biomed Eng. 2013; 41(2):91-123. invited
review.
22. Williams SK, Touroo JS, Church KH, Hoying JB. Encapsulation of adipose stromal vascular
fraction cells in alginate hydrogel spheroids using a direct-write three-dimensional printing system.
Biores Open Access. 2013; 2(6):448-54.
23. Türker T, Murphy E, Kaufman CL, Kutz JE, Meister EA, Hoying JB. Response of dupuytren
fibroblasts to different oxygen environments. J Hand Surg Am. 2013; 38(12):2365-9.
24. LeBlanc A, Nguyen QT, Touroo JS, Aird AL, Chang RC, Ng CK, Hoying JB, and Williams SK.
Adipose-derived cell construct stabilizes heart function and increases microvascular perfusion in an
established infarct. Stem Cells Trans Med. 2013; 2(11):896-905.
25. Nunes SS, Maijub JG, Krishnan L, Ramakrishnan VM, Clayton LR, Williams SK, Boyd NL, and
Hoying JB. Generation of a functional liver tissue mimic using adipose stromal vascular fraction
cell-derived vasculatures. Nature: Scientific Reports. 2013; 3:2141. PMCID: PMC3701895.
Hoying, James B January, 2016
40
26. Junkin M, Lu Y, Long J, Deymier PA, Hoying JB, Wong PK. Mechanically induced intercellular
calcium communication in confined endothelial structures. Biomaterials. 2013;34(8):2049-56.
PMCID: 3542404.
27. Boyd NL, Nunes SS, Krishnan L, Jokinen JD, Ramakrishnan VM, Bugg AR, and Hoying JB.
Dissecting the Role of Human Embryonic Stem Cell-Derived Mesenchymal Cells in Human
Umbilical Vein Endothelial Cell Network Stabilization in Three-Dimensional Environments. Tissue
Eng Part A 2013. 19(1-2):211-23.
28. Long J, Junkin M, Wong PK, Hoying J, and Deymier P. Calcium wave propagation in networks of
endothelial cells: model-based theoretical and experimental study. PLoS Comput Biol.
2012;8(12):e1002847.
29. Leblanc AJ, Krishnan L, Sullivan CJ, Williams SK, and Hoying JB. Microvascular Repair: Post-
Angiogenesis Vascular Dynamics. Microcirculation. 2012. 19(8):676-95.
30. Gruionu G, Hoying JB, Pries AR, and Secomb TW. Structural Remodeling of the Mouse Gracilis
Artery: Coordinated Changes in Diameter and Medial Area Maintain Circumferential Stress.
Microcirculation. 2012. 19(7):610-8.
31. LeBlanc AJ, Touroo JS, Hoying JB, and Williams SK. Adipose stromal vascular fraction cell
construct sustains coronary microvascular function after acute myocardial infarction. Am J Physiol
Heart. 2012. 302(4):H973-82.
32. Chang CC, Krishnan L, Nunes SS, Church KH, Edgar LT, Boland ED, Weiss JA, Williams SK,
Hoying JB. Determinants of Microvascular Network Topologies in Implanted Neovasculatures.
2012. Arterioscler. Thromb. Vasc. Biol. 32(1):5-14.
33. Stabenfeldt SE, Gourley M, Krishnan L, Hoying JB, and Barker TH. Engineering fibrin polymers
through engagement of alternative polymerization mechanisms. Biomaterials. 2012 Jan,33(2):535-
44.
34. Cardinal TR, Struthers KR, Kesler TJ, Yocum MD, Kurjiaka DT, and Hoying JB. Chronic hindlimb
ischemia impairs functional vasodilation and vascular reactivity in mouse feed arteries. 2011. Front.
Physio. 2:91.
35. Nunes SS, Rekapally H, Chang CC, and Hoying JB. Vessel arterial-venous plasticity in adult
neovascularization. PLoS One. 2011. 6(11):e27332.
36. Krishnan L, Clayton LR, Boland ED, Reed RM, Hoying JB, and Williams SK. Cellular
immunoisolation for islet transplantation by a novel dual porosity electrospun membrane.
Transplant Proc. 43(9):3256-61. 2011.
37. Boyd NL, Nunes SS, Jokinen JD, Krishnan L, Chen Y, Smith KH, Stice SL, Hoying JB.
Microvascular Mural Cell Functionality of Human Embryonic Stem Cell-Derived Mesenchymal
Cells. Tissue Eng Part A. 2011. 17(11-12):1537-48.
38. Chang CC, Boland ED, Williams SK, and Hoying JB. Direct-write Bioprinting Three-Dimensional
Biohybrid Systems for Future Regenerative Therapies. J Biomed. Mat. Res. A. 2011. 98(1):160-70.
Hoying, James B January, 2016
41
39. Myers SA, Devries WH, Sorg KR, Gruenthal MJ, Benton RL, Hoying JB, Hagg T, Whittemore SR.
CD47 knockout mice exhibit improved recovery from spinal cord injury. Neurobiol Dis. 2011
42(1):21-34.
40. Diamond-Stanic MK, Romero-Aleshire MJ, Hoyer PB, Greer K, Hoying JB, Brooks HL. Midkine,
a heparin-binding protein, is increased in the diabetic mouse kidney postmenopause. Am J Physiol
Renal Physiol. 2011. 300(1):F139-46.
41. Gruionu, G, Stone AL, Schwartz MA, Hoying JB, and Williams SK. Gruionu, G, Stone AL,
Schwartz MA, Hoying JB, and Williams SK. Encapsulation of ePTFE in prevascularized collagen
leads to peri-implant vascularization with reduced inflammation. J. Biomedical Materials Research
A. 2010. 95(3):811-8.
42. Nunes SS, Krishnan L, Gerard CS, Dale JR, Maddie MA, Benton RL, and Hoying JB. Angiogenic
Potential of Microvessel Fragments is Independent of the Tissue of Origin and can be Influenced by
the Cellular Composition of the Implants. Microcirculation. 2010. 17(7): 557–567.
43. Bernas MJ, Cardoso FL, Daley SK, Weinand ME, Campos AR, Ferreira AJ, Hoying JB, Witte MH,
Brites D, Persidsky Y, Ramirez SH, Brito MA. Establishment of primary cultures of human brain
microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nat
Protocols. 2010 5(7):1265-72.
44. Deymier PA, Runge K, Deymier MJ, Hoying JB, Vasseur JO. Calcium wave propagation in chains
of endothelial cells with nonlinear reaction dynamics: Green's function approach. Phys Rev E Stat
Nonlin Soft Matter Phys. 2010. 82(4 Pt 1):041913.
45. Deymier PA, Eray M, Deymier MJ, Runge K, Hoying JB, Vasseur JO. Architecture-dependent
signal conduction in model networks of endothelial cells. Phys.Rev.E.Stat.Nonlin.Soft.Matter Phys.
2010 Apr,81(4 Pt 1):041915
46. Chang CC, Nunes SS, Sibole SC, Krishnan L, Williams SK, Weiss JA, Hoying JB. Angiogenesis in
a microvascular construct for transplantation depends on the method of chamber circulation. Tissue
Eng Part A 2010 Mar,16(3):795-805. PMCID:PMC2862615
47. Nunes SS, Greer KA, Stiening CM, Chen HY, Kidd KR, Schwartz MA, Sullivan CJ, Rekapally H,
Hoying JB. Implanted microvessels progress through distinct neovascularization phenotypes.
Microvasc.Res. 2010 Jan,79(1):10-20. PMCID:PMC2813398
48. Rhoads RP, Johnson RM, Rathbone CR, Liu X, Temm-Grove C, Sheehan SM, Hoying JB, Allen
RE. Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible
factor pathway. Am.J.Physiol Cell Physiol 2009 Jun,296(6):C1321-C1328. PMCID:PMC2692418
49. Valenzuela K, Raghavan S, Deymier PA, Hoying J. Formation of copper nanowires by electroless
deposition using microtubules as templates. J.Nanosci.Nanotechnol. 2008 Jul,8(7):3416-21
50. Fernandez SM, Keating AF, Christian PJ, Sen N, Hoying JB, Brooks HL, Hoyer PB. Involvement
of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss
in rats. Biol.Reprod. 2008 Aug,79(2):318-27. PMCID:PMC2714991
Hoying, James B January, 2016
42
51. Krishnan L, Underwood CJ, Maas S, Ellis BJ, Kode TC, Hoying JB, Weiss JA. Effect of
mechanical boundary conditions on orientation of angiogenic microvessels. Cardiovasc.Res. 2008
May 1,78(2):324-32
52. Stiening CM, Hoying JB, Abdallah MB, Hoying AM, Pandey R, Greer K, Collier RJ. The effects of
endocrine and mechanical stimulation on stage I lactogenesis in bovine mammary epithelial cells.
J.Dairy Sci. 2008 Mar,91(3):1053-66.
53. Eray M, Deymier P.A., Hoying JB, Runge K, and Vasseur JO. Resonant filtering of compositional
waves in multicellular networks. 2008. Physica D 237:2777- 2786.
54. Castro JS, Trzaskowski B, Deymier PA, Bucay J, Adamowicz L, and Hoying JB. Binding Affinity
of Fluorochromes and Fluorescent Proteins to Taxol Crystals. 2008. J. Mat. Sci. Engr. C. 29, 1609-
1615.
55. Castro JS, Deymier PA, Smith SD, and Hoying JB. Morphology of Microtubules Grown in Agarose
Gels. 2008. Advanced Materials 20:183-188.
56. Hiscox AM, Stone AL, Limesand S, Hoying JB, Williams SK. An Islet-Stabilizing Implant
Constructed Using a Preformed Vasculature. Tissue Eng 2007 Dec 21,
57. Maitra N, Adamson C, Greer K, Klewer S, Hoying J, Bahl JJ, Goldman S, Morkin E. Regulation of
gene expression in rats with heart failure treated with the thyroid hormone analog 3,5-
diiodothyropropionic acid (DITPA) and the combination of DITPA and captopril.
J.Cardiovasc.Pharmacol. 2007 Nov,50(5):526-34
58. Krishnan L, Hoying JB, Nguyen H, Song H, Weiss JA. Interaction of angiogenic microvessels with
the extracellular matrix. Am.J.Physiol Heart Circ.Physiol 2007 Dec,293(6):H3650-H3658
59. Cai Q, McReynolds MR, Keck M, Greer KA, Hoying JB, Brooks HL. Vasopressin receptor subtype
2 activation increases cell proliferation in the renal medulla of AQP1 null mice. Am.J.Physiol Renal
Physiol 2007 Dec,293(6):F1858-F1864
60. Shepherd BR, Hoying JB, Williams SK. Microvascular transplantation after acute myocardial
infarction. Tissue Eng 2007 Dec,13(12):2871-9
61. Pysher MD, Sollome JJ, Regan S, Cardinal TR, Hoying JB, Brooks HL, Vaillancourt RR. Increased
hexokinase II expression in the renal glomerulus of mice in response to arsenic.
Toxicol.Appl.Pharmacol. 2007 Oct 1,224(1):39-48. PMCID:PMC2042004
62. Cardinal TR, Hoying JB. A modified fluorescent microsphere-based approach for determining
resting and hyperemic blood flows in individual murine skeletal muscles. Vascul. Pharmacol. 2007
Jul,47(1):48-56. PMCID:PMC2041860
63. Smith CM, Cole SJ, Williams SK, Rodriguez JJ, Hoying JB. Automatic thresholding of three-
dimensional microvascular structures from confocal microscopy images. J.Microsc. 2007
Mar,225(Pt 3):244-57
64. Kirkpatrick ND, Andreou S, Hoying JB, Utzinger U. Live imaging of collagen remodeling during
angiogenesis. Am.J.Physiol Heart Circ.Physiol 2007 Jun,292(6):H3198-H3206
Hoying, James B January, 2016
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65. Chakraborty A, Brooks H, Zhang P, Smith W, McReynolds MR, Hoying JB, Bick R, Truong L,
Poindexter B, Lan H, et al. Stanniocalcin-1 regulates endothelial gene expression and modulates
transendothelial migration of leukocytes. Am.J.Physiol Renal Physiol 2007 Feb,292(2):F895-F904.
66. Ramos RF, JB Hoying, Witte MH, Daniel Stamer W. 2007. Schlemm's canal endothelia, lymphatic,
or blood vasculature? J Glaucoma. 16(4):391-405.
67. Kirkpatrick ND, Hoying JB, Botting SK, Weiss JA, Utzinger U. In vitro model for endogenous
optical signatures of collagen. J.Biomed.Opt. 2006 Sep,11(5):054021
68. Chang CC, Hoying JB. Directed three-dimensional growth of microvascular cells and isolated
microvessel fragments. Cell Transplant. 2006,15(6):533-40
69. Calaluce R, Beck SK, Bair EL, Pandey R, Greer KA, Hoying AM, Hoying JB, Mount DW, Nagle
RB. Human laminin-5 and laminin-10 mediated gene expression of prostate carcinoma cells.
Prostate 2006 Sep 15,66(13):1381-90
70. Greer KA, McReynolds MR, Brooks HL, Hoying JB. CARMA: A platform for analyzing
microarray datasets that incorporate replicate measures. BMC.Bioinformatics. 2006,7:149.
PMCID:PMC1450302
71. Cai Q, Keck M, McReynolds MR, Klein JD, Greer K, Sharma K, Hoying JB, Sands JM, Brooks
HL. Effects of water restriction on gene expression in mouse renal medulla: identification of
3betaHSD4 as a collecting duct protein. Am.J.Physiol Renal Physiol 2006 Jul,291(1):F218-F224
72. Yang Y, Deymier PA, Wang L, Guzman R, Hoying JB, McLaughlin HJ, Smith SD, Jongewaard IN.
Nucleation and growth of microtubules from gamma-tubulin-functionalized gold surfaces.
Biotechnol.Prog. 2006 Jan,22(1):303-12
73. Guilkey JE, Hoying JB, Weiss JA. Computational modeling of multicellular constructs with the
material point method. J.Biomech. 2006,39(11):2074-86
74. Vartanian KB, Chen HY, Kennedy J, Beck SK, Ryaby JT, Wang H, Hoying JB. The non-
proteolytically active thrombin peptide TP508 stimulates angiogenic sprouting. J.Cell Physiol 2006
Jan,206(1):175-80
75. Shiu YT, Weiss JA, JB Hoying, Iwamoto MN, Joung IS and Quam CT. The role of mechanical
stresses in angiogenesis. Crit Rev Biomed Eng 33: 431-510, 2005.
76. Yang Y, Guzman R, Deymier PA, Umnov M, Hoying J, Raghavan S, Palusinski O, Zelinski BJ.
Adsorption of a microtubule on a charged surface affects its disassembly dynamics.
J.Nanosci.Nanotechnol. 2005 Dec,5(12):2050-6
77. Kidd KR, Dal PD, Stone AL, Hoying JB, Nagle RB, Williams SK. Stimulated endothelial cell
adhesion and angiogenesis with laminin-5 modification of expanded polytetrafluoroethylene. Tissue
Eng 2005 Sep,11(9-10):1379-91
78. Deymier PA, Yang Y, Hoying J. Effect of tubulin diffusion on polymerization of microtubules.
Phys.Rev.E.Stat.Nonlin.Soft.Matter Phys. 2005 Aug,72(2 Pt 1):021906
79. Schwartz MA, Stone AL, Greer KA, Hoying JB, Williams SK. Gene expression in tissue associated
with extracellular matrix modified ePTFE. J.Biomed.Mater.Res.A 2005 Apr 1,73(1):30-8
Hoying, James B January, 2016
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80. Gruionu G, Hoying JB, Gruionu LG, Laughlin MH, Secomb TW. Structural adaptation increases
predicted perfusion capacity after vessel obstruction in arteriolar arcade network of pig skeletal
muscle. Am.J.Physiol Heart Circ.Physiol 2005 Jun,288(6):H2778-H2784
81. Gruionu G, Hoying JB, Pries AR, Secomb TW. Structural remodeling of mouse gracilis artery after
chronic alteration in blood supply. Am.J.Physiol Heart Circ.Physiol 2005 May,288(5):H2047-
H2054
82. McReynolds MR, Taylor-Garcia KM, Greer KA, Hoying JB, Brooks HL. Renal medullary gene
expression in aquaporin-1 null mice. Am.J.Physiol Renal Physiol 2005 Feb,288(2):F315-F321
83. Brewer MA, Utzinger U, Barton JK, Hoying JB, Kirkpatrick ND, Brands WR, Davis JR, Hunt K,
Stevens SJ, Gmitro AF. Imaging of the ovary. Technol.Cancer Res.Treat. 2004 Dec,3(6):617-27
84. Adamson C, Maitra N, Bahl J, Greer K, Klewer S, Hoying J, Morkin E. Regulation of gene
expression in cardiomyocytes by thyroid hormone and thyroid hormone analogs 3,5-
diiodothyropropionic acid and CGS 23425 [N-[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylphenoxy)-
phenyl]-oxamic acid]. J.Pharmacol.Exp.Ther. 2004 Oct,311(1):164-71
85. Krishnan L, Weiss JA, Wessman MD, Hoying JB. Design and application of a test system for
viscoelastic characterization of collagen gels. Tissue Eng 2004 Jan,10(1-2):241-52
86. Shepherd BR, Chen HY, Smith CM, Gruionu G, Williams SK, Hoying JB. Rapid perfusion and
network remodeling in a microvascular construct after implantation.
Arterioscler.Thromb.Vasc.Biol. 2004 May,24(5):898-904
87. Sullivan CJ, Doetschman T, Hoying JB. Targeted disruption of the Fgf2 gene does not affect
vascular growth in the mouse ischemic hindlimb. J.Appl.Physiol 2002 Dec,93(6):2009-17
88. Sullivan CJ, Hoying JB. Flow-dependent remodeling in the carotid artery of fibroblast growth
factor-2 knockout mice. Arterioscler.Thromb.Vasc.Biol. 2002 Jul 1,22(7):1100-5
89. Barton JK, Hoying JB, Sullivan CJ. Use of microbubbles as an optical coherence tomography
contrast agent. Acad.Radiol. 2002 May,9 Suppl 1:S52-S55
90. Schultz JJ, Hoying JB, Sullivan CJ, Doetschman T. FGF and the cardiovascular system. In: Cuevas
P, editor. Fibroblast growth factor in the cardiovascular system. I. Holzapfel, 2001.
91. Carter WB, Hoying JB, Boswell C, Williams SK. HER2/neu over-expression induces endothelial
cell retraction. Int.J.Cancer 2001 Feb 1,91(3):295-9
92. Carter WB, Uy K, Ward MD, Hoying JB. Parathyroid-induced angiogenesis is VEGF-dependent.
Surgery 2000 Sep,128(3):458-64
93. Hoying JB, Yin M, Diebold R, Ormsby I, Becker A, Doetschman T. Transforming growth factor
beta1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor.
J.Biol.Chem. 1999 Oct 22,274(43):31008-13
94. Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. Transforming growth
factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res.
1999 Jul 15,59(14):3379-86
Hoying, James B January, 2016
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95. Sutliff RL, Hoying JB, Kadambi VJ, Kranias EG, Paul RJ. Phospholamban is present in endothelial
cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-
ablated mice. Circ.Res. 1999 Feb 19,84(3):360-4
96. Zhou M, Sutliff RL, Paul RJ, Lorenz JN, Hoying JB, Haudenschild CC, Yin M, Coffin JD, Kong L,
Kranias EG, et al. Fibroblast growth factor 2 control of vascular tone. Nat.Med. 1998 Feb,4(2):201-
7
97. Liu LH, Paul RJ, Sutliff RL, Miller ML, Lorenz JN, Pun RY, Duffy JJ, Doetschman T, Kimura Y,
MacLennan DH, et al. Defective endothelium-dependent relaxation of vascular smooth muscle and
endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase
isoform 3. J.Biol.Chem. 1997 Nov 28,272(48):30538-45
98. Hoying JB, Williams SK. Effects of basic fibroblast growth factor on human microvessel
endothelial cell migration on collagen I correlates inversely with adhesion and is cell density
dependent. J.Cell Physiol 1996 Aug,168(2):294-304
99. Hoying JB, Boswell CA, Williams SK. Angiogenic potential of microvessel fragments established
in three-dimensional collagen gels. In Vitro Cell Dev.Biol.Anim 1996 Jul,32(7):409-19
100. Kleinert LB, Hoying JB, Williams SK. The neointima formed in endothelial cell sodded ePTFE
vascular grafts results from both cellular-hyperplasia and extracellular-hypertrophy. Cell
Transplant. 1996 Jul,5(4):475-82
101. Hoying JB, Williams SK. Measurement of endothelial cell migration using an improved linear
migration assay. Presented at the 1995 Microcirculatory Society Meeting. Microcirculation. 1996
Jun,3(2):167-74
102. Hoying JB, Chen SC, Williams SK. Interaction of colloidal gold-labelled glucosylated albumin
with endothelial cell monolayers: comparison between cryofixation and glutaraldehyde fixation.
Microsc.Res.Tech. 1995 Feb 15,30(3):252-7
103. Wu P, Hoying JB, Williams SK, Kozikowski BA, Lauffenburger DA. Integrin-binding peptide
in solution inhibits or enhances endothelial cell migration, predictably from cell adhesion.
Ann.Biomed.Eng 1994 Mar,22(2):144-52
104. Hoying JB, Williams SK. Endothelial cell monolayers viewed by TIRF microscopy. In Vitro
Cell Dev.Biol.Anim 1994 Jan,30A(1):1-3
105. Young C, Jarrell BE, Hoying JB, Williams SK. A porcine model for adipose tissue-derived
endothelial cell transplantation. Cell Transplant. 1992,1(4):293-8
106. Hoying JB, Behm SM, Lang-Unnasch N. Cloning and characterization of
Rhizobium meliloti loci required for symbiotic root nodule invasion. Mol.Plant Microbe Interact.
1990 Jan,3(1):18-27.
Manuscripts in Review/ Revision/Preparation.
Hoying, James B January, 2016
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Jacob R. Dale JR, Breite AG, Clayton L, Dwulet FE, McCarthy RC, McCurry T, Williams SK, and
Hoying JB. Impact of Enzyme Composition on Stromal Vascular Fraction Cell Isolation from Adipose
Tissue. Cell Transplantation. in review.
Adeyemo A, Zhang Y, Doetschman T, Hoying JB, and Schultz JEJ. High molecular weight isoforms of
fibroblast growth factor-2 are sufficient and necessary for post-ischemic revascularization and recovery
of the mouse hindlimb. ATVB. Revision in review
Krishnan L, Nunes SS, Chang CC, Clayton L, Williams SK, and Hoying JB. Invasion of tissue
interfaces by angiogenic neovessels requires stromal cells and is VEGF-dependent. PLoS One. in
preparation
Krishnan L, Chang CC, Rekapally H, Williams SK, and Hoying JB. Insulinemia and not hyperglycemia
impairs vascular sprouting in a model of adipose angiogenesis. Cardiovasc. Diabetol. in preparation
Books and Book Chapters
Hoying JB, Dale J, Touroo J, Howard A, Chang CC, and Williams SK. Direct-write Bioprinting of a
3D Vascularized Tissue Model. In Dudley A, Ed. Methods in Organogenesis; Methods in
Molecular Biology series. Humana Press. 2016. in press.
Williams SK and Hoying JB. Bioinks for Bioprinting. In: Bioprinting in Regenerative Medicine
Springer. 2015.
Hoying JB and Williams SK. Biofabrication of Vascular Networks. In Atala A and Yoo JJ, Eds. 3D
Biofabrication for Biomedical and Translational Research. Elsevier, 2015.
Williams SK and Hoying JB. Adipose Stromal Vascular Fraction Cells for Vascularization of
Engineered Tissues. In Brey EM, Ed. Vascularization: Regenerative Medicine and Tissue
Engineering. CRC Press, 2014.
Keller BB, Hoying JB, Markwald RR. Molecular Development of the Heart. In Furster V, Walsh RA
and Harrington RA, Eds. Hurst’s The Heart, Thirteenth Edition. The McGraw-Hill Companies, Inc.
2011.
Hoying JB and Williams SK. Building blood vessels. In Aird W.C, Ed. Endothelial Biomedicine.
Cambridge: Cambridge University Press, 2007.
Hoying JB, editor. Genetics of Angiogenesis. United Kingdom: BIOS Scientific Publishers Ltd. 2003.
Hoying JB, KR. Kidd and CJ Sullivan. Heterogeneity of Angiogenesis. Genetics of Angiogenesis.
Hoying (ed.), United Kingdom: BIOS Scientific Publishers Ltd. 2003, ppg. 191-203.
Williams SK and JB Hoying. Angiogenesis and Biomaterials. Encyclopedia of Biomaterials and
Biomedical Engineering. Wenk G and Bowlin G, eds, Marcel Dekker, Inc. Publishers. New York,
NY. 2002.
Hoying, James B January, 2016
47
Schultz, JJ, JB Hoying, CJ Sullivan, and T Doetschman. 2001. FGF and the cardiovascular system. In
Fibroblast growth factor in the cardiovascular system. P.Cuevas, editor. I. Holzapfel, Publisher.