Upload
arfiearfie
View
171
Download
5
Tags:
Embed Size (px)
Citation preview
HypersensitivityArfiani Dwi Ika Endra Kusumawati
Kusumaningtyas
Definition (MSH)
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Definition (CSP)
state of previously immunized body in which tissue damage results from the immune response to a further dose of antigen.
Definition (HL7V3.0)Hypersensitivity to an agent caused by an immunologic response to an initial exposure
Definition (NCI)
Hypersensitivity; a local or general reaction of an organism following contact with a specific allergen to which it has been previously exposed and to which it has become sensitized.
Definition (NCI)An exaggerated response by the immune system to a drug or other substance.
Definition (GO)
An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
Hipersensitivitas ????
Gambar : Sistem imunitas yang non spesifik dan yang spesifik
Type I Type II
Type III Type IV
Classification
Type I anaphylactic hypersensitivity
HYPERSENSITIVITY TYPE I
Type II ADCC/CDC
Type II ADCC/CDC
Antibody-dependent cell-mediated cytotoxicity ADCC
Natural killer cell Macrophage
Cell
surface
antigen
Monoclonal
antibodyFc
receptor
Complement
pathway
Lymphoma cell
Type II ADCC/CDC
Type III immunecomplex
Tipe Ig/Ly Patogenesis Penyakit Hipersensitivitas
I Ig E IgE terikat pada sel Mast berikatan dengan Ag, menstimuli degranulasi Histamin. Relaksasi otot polos kapiler dan kontriksi otot polos saluran nafas
Urtikaria, Asma, Syok
Anafilaktik
II IgG, IgM
Antibodi bereaksi dengan Ag yang berada pada membran. Aktivasi Komplemen, dan menarik sel lekosit, lisis membran
Ketidak cocokan gol darah (transfusi)
Sitotoksik bergantung pada
Ab (ADCC)
III IgG, IgM
Antibodi berikatan dengan Ag partikel larut, membentuk kompleks yang beredar ikut sirkulasi, terperangkap, aktivasi komplemen, lisis membrane dan menarik lekosit
Penyakit serum,Glomerulonefritis akut. , SLE
Kompleks imun
IV Ly T Ag menstimuli Ly T-CD4, dihasilkan sitokin, mengaktifkan Ly T-CD8, makrofag. Timbul nekrosis, sebukan Ly dan Histiosit (epiteloid), sel Datia
Test Mantoux,Tuberkel (TBC)
Tipe lambat
HIPERSENSITIVITAS SISTEM IMUN HUMORAL DAN SELULER