I-BIO Frontier Fellowship 모집 연구 분야

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1. 국가과학자 연구주제 1. 국가과학자 연구주제

I-BIO Frontier Fellowship 모집 연구 분야

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Aging mechanism

Biochemical nature, endocytosis mechanism of superoxide vesicle in Arabidospis

Systems genetics approaches to understand aging and senescence in plants

Systems genetic approaches to understand aging in C. elegans including mapping of death

참여교수 : 남홍길

RNA systems biology and chemistry

RNA imaging in vivo and spatial regulation of RNA in plants and others

RNA-based network in plants and C. elegans

RNA structure mapping: AFM-based experiment  

RNA modification and its role

Modulation of RNA species in development

참여교수 : 남홍길

Photoresponses

Systems approaches and imaging approaches for plant photoresponses and circadian rhythms

참여교수 : 남홍길

Aging mechanism

Biochemical nature, endocytosis mechanism of superoxide vesicle in Arabidospis

Systems genetics approaches to understand aging and senescence in plants

Systems genetic approaches to understand aging in C. elegans including mapping of death

참여교수 : 남홍길

RNA systems biology and chemistry

RNA imaging in vivo and spatial regulation of RNA in plants and others

RNA-based network in plants and C. elegans

RNA structure mapping: AFM-based experiment  

RNA modification and its role

Modulation of RNA species in development

참여교수 : 남홍길

Photoresponses

Systems approaches and imaging approaches for plant photoresponses and circadian rhythms

참여교수 : 남홍길

2. I-BIO 공동연구 분야2. I-BIO 공동연구 분야

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Photosynthesis

Assembly and dynamics of photosynthetic complex with superresolution imaging

Photochemical reaction/dynamic modeling and spectroscopic, and imaging experiment.

Imaging photochemistry and physics with AFM and fast spectroscopy

참여교수 : 남홍길

Imaging technology

For superresolution imaging

For dynamic imaging

For high throughput imaging

참여교수 : 남홍길

Chemical Genetics

For photosynthetic components

For controlling plant development such as flowering

For controlling lignin using reverse chemical genetics

참여교수 : 남홍길

Photosynthesis

Assembly and dynamics of photosynthetic complex with superresolution imaging

Photochemical reaction/dynamic modeling and spectroscopic, and imaging experiment.

Imaging photochemistry and physics with AFM and fast spectroscopy

참여교수 : 남홍길

Imaging technology

For superresolution imaging

For dynamic imaging

For high throughput imaging

참여교수 : 남홍길

Chemical Genetics

For photosynthetic components

For controlling plant development such as flowering

For controlling lignin using reverse chemical genetics

참여교수 : 남홍길

I-BIO Frontier Fellowship 모집 연구 분야

I-BIO Frontier Fellowship 모집 연구 분야

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Title: Mathematical modeling and analysis of biological systems

Summary: We aim to apply mathematical modeling, and numerical and analytical analysis to discover

underlying principles of systems and to develop systematic theories for biological phenomena.

참여교수 : 남홍길 , 황형주 

 

Title: Non-Labeling Single Biomolecule Imaging Technology: Force-Based Atomic Force Microscopy (Joon Won

Park)

Summary: Dynamic force microscopy has been used widely to reveal behaviors of single biomolecules during

the last 20 years. Precise control of surface architecture of the AFM probe revealed that the capacity of the

force-based tool was beyond what people have seen. In particular, guaranteeing truly the single molecular

interaction during the measurement enables to "see" biomolcules such as proteins and DNA/RNA one by one

with high accuracy. Therefore, it now is possible to map the biomolecules on a solid substrate as well as tissue

at the single molecule level. Numerous applications can be envisaged with the non-labeling and non-

amplification approach showing the ultimate resolution.

참여교수 : 남홍길 , 박준원

Title: RNA bases biologycal network: technology development and application

Summary: multiplexed single cell mRNA counting

참여교수 : 남홍길 , 이남기

Title: Mathematical modeling and analysis of biological systems

Summary: We aim to apply mathematical modeling, and numerical and analytical analysis to discover

underlying principles of systems and to develop systematic theories for biological phenomena.

참여교수 : 남홍길 , 황형주 

 

Title: Non-Labeling Single Biomolecule Imaging Technology: Force-Based Atomic Force Microscopy (Joon Won

Park)

Summary: Dynamic force microscopy has been used widely to reveal behaviors of single biomolecules during

the last 20 years. Precise control of surface architecture of the AFM probe revealed that the capacity of the

force-based tool was beyond what people have seen. In particular, guaranteeing truly the single molecular

interaction during the measurement enables to "see" biomolcules such as proteins and DNA/RNA one by one

with high accuracy. Therefore, it now is possible to map the biomolecules on a solid substrate as well as tissue

at the single molecule level. Numerous applications can be envisaged with the non-labeling and non-

amplification approach showing the ultimate resolution.

참여교수 : 남홍길 , 박준원

Title: RNA bases biologycal network: technology development and application

Summary: multiplexed single cell mRNA counting

참여교수 : 남홍길 , 이남기

3. I-BIO 공동 연구 과제3. I-BIO 공동 연구 과제

I-BIO Frontier Fellowship 모집 연구 분야

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Title: Dynamics of membrane protein complex: Single molecule biophysics

Summary: dynamic biology with super-resolution imaging technique

참여교수 : 남홍길 , 이남기

Title: Decoding RNA networks governing aging dependent senescence.

Summary:

-  Objective: Decoding of functional RNA networks governing aging-dependent senescence

-  Contents: 1) generation of RNA & small RNA deep sequencing data of young and aged plants,

2) identification of functional RNA associated with aging-dependent senescence, 3) measurement of RNA-RNA

and RNA-protein interactions involving the identified functional RNAs, 4) refinement of measured RNA-RNA and

RNA-protein interactions based on in-silico RNA interaction prediction methods, 5) reconstruction of aging

associated RNA networks using refined RNA interaction, 6) identification of key functional RNA network

modules, and 7) experimental validation of the functional contexts of operations of RNA network modules

using imaging, genetics, molecular and cellular biological technologies.

-  Benefits: Expansion of current limited knowledge of miRNA and few RNA-protein interactions based small

RNA networks into general functional RNA networks including interactions of functional RNAs with key

elements in the systems. Platform technologies for decoding functional RNA networks can be established,

which can be used to study RNA related key cellular networks in living organisms.

참여교수 : 남홍길 , 황대희

Title: Dynamics of membrane protein complex: Single molecule biophysics

Summary: dynamic biology with super-resolution imaging technique

참여교수 : 남홍길 , 이남기

Title: Decoding RNA networks governing aging dependent senescence.

Summary:

-  Objective: Decoding of functional RNA networks governing aging-dependent senescence

-  Contents: 1) generation of RNA & small RNA deep sequencing data of young and aged plants,

2) identification of functional RNA associated with aging-dependent senescence, 3) measurement of RNA-RNA

and RNA-protein interactions involving the identified functional RNAs, 4) refinement of measured RNA-RNA and

RNA-protein interactions based on in-silico RNA interaction prediction methods, 5) reconstruction of aging

associated RNA networks using refined RNA interaction, 6) identification of key functional RNA network

modules, and 7) experimental validation of the functional contexts of operations of RNA network modules

using imaging, genetics, molecular and cellular biological technologies.

-  Benefits: Expansion of current limited knowledge of miRNA and few RNA-protein interactions based small

RNA networks into general functional RNA networks including interactions of functional RNAs with key

elements in the systems. Platform technologies for decoding functional RNA networks can be established,

which can be used to study RNA related key cellular networks in living organisms.

참여교수 : 남홍길 , 황대희

I-BIO Frontier Fellowship 모집 연구 분야

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Title: Quantum chemical phenomenon in biology

Summary: In this project, quantum chemical behaviors in biological systems (e.g. photoproteins and

photosynthetic systems) will be studied on a theoretical basis.

참여교수 : 남홍길 , 이영민

Title: Study of ultrafast dynamical phenomena in photosynthesis

Summary: In this project, we are interested in various dynamical processes occurring in photosynthesis and

related subjects such as

Photon capture, electron transfer, oxygen reduction and quantum coherence, using femtosecond / attosecond

optics. This study will also have close collaboration with Prof. Nam, Hong Gil for sample preparation and with

Prof Lee, Young Min and Prof. Park, Ki Soo for theoretical support.

참여교수 : 남홍길 , 김동언

 

Title: tRNA population dynamics in aging process

Summary: 1) development of precise and efficient tRNA population analysis method 2) analysis of correlation

between tRNA population and aging

참여교수 : 남홍길 , 정규열

Title: Quantum chemical phenomenon in biology

Summary: In this project, quantum chemical behaviors in biological systems (e.g. photoproteins and

photosynthetic systems) will be studied on a theoretical basis.

참여교수 : 남홍길 , 이영민

Title: Study of ultrafast dynamical phenomena in photosynthesis

Summary: In this project, we are interested in various dynamical processes occurring in photosynthesis and

related subjects such as

Photon capture, electron transfer, oxygen reduction and quantum coherence, using femtosecond / attosecond

optics. This study will also have close collaboration with Prof. Nam, Hong Gil for sample preparation and with

Prof Lee, Young Min and Prof. Park, Ki Soo for theoretical support.

참여교수 : 남홍길 , 김동언

 

Title: tRNA population dynamics in aging process

Summary: 1) development of precise and efficient tRNA population analysis method 2) analysis of correlation

between tRNA population and aging

참여교수 : 남홍길 , 정규열