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Ian DeLaCruz
Kevin Chung
Dan Ipaktchi
Melinda Disharoon
Outline the difference between
micronutrients and macronutrients
Macronutrients vs. Micronutrients Found in relatively
large amounts (>0.005% of body weight)
Provides energy Ex. Na, Mg, K, Ca, P,
S and Cl
Found in small amounts (<0.005% of body weight)
Acts as a co-factor of enzymes
Ex. Fe,Cu, F, Zn, I, Se, Mn, Mo, Cr, Co and B
Compare the structures of
retinol (vitamin A), calciferol (vitamin D),
and ascorbic acid (vitamin C)
Retinol (Vitamin A)
Yellow, fat soluble subtanceMolecular Formula- C20H30O
Molar Mass- 286.4516 g mol−1 Chemical name
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraen-1-ol ○ Chemical doesn’t need to be learned
Retinol (Vitamin A) Only 1 hydroxyl group Long polyalkene chain Carbon ring and chain are non-polar
Influence solubulity more than OH group Overall non-polar
Doesn’t dissolve in waterFat soluble
Important for vision, particularly at low light intensity
Retinol (Vitamin A)
Calciferol (Vitamin D)
White powdery crystallineMolecular Formula- C27H44O
Molar Mass- 384.64 g/mol ○ Chemical name
(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
Calciferol (Vitamin D)
4 Hydrocarbon rings and alkane chain are non-polar
Only 1 hydroxyl group Overall non-polar
Stimulates uptake of calcium ions by cellsImportant in health of teeth and bones
Calciferol (Vitamin D)
Ascorbic acid (Vitamin C)
White/Yellow solidMolecular Formula- C6H8O6
Molar Mass- 176.12 g mol−1
○ Chemical name
5R)-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one
Ascorbic acid (Vitamin C) 4 hydroxyl groups Several OH groups enable oxygen bonds to form
with water Ester bond within the ring Polar due to hydroxyl groups
Easily dissolvable in water
Cofactor in some enzyme reactions Important in tissue regeneration after injury Helps give resistance to some diseases
Ascorbic acid (Vitamin C)
Deduce whether a vitamin is
water- or fat- soluble from its structure
Fat soluble
Relatively non-polar Consist mainly of hydrocarbons Remember:
All Dogs Eat Kibbles
Water soluble
Have a high proportion of electronegative atoms
Water-Soluble VitaminsB and C
Fat vs. water soluble
Water solubleExcess of the vitamin will come out in urine
Fat solubleCan cause sickness because it is stored in
the body and not easily released
Vitamin A
Overall non-polarnot water solubleFat soluble
Consists mostly of hydrocarbons
Vitamin D
Overall non-polarNot water solubleFat soluble
Consists mostly of hydrocarbons
Vitamin C
PolarWater soluble
Hydroxyl group makes it overall electronegative
Discuss the causes and effects of nutrient
deficiencies in different countries and
suggest solutions
Malnutrition What causes malnutrition?
Lack of distribution of global resources Depletion of nutrients in the soil and water cultures
through soil erosion Lack of education about, or understanding of the
importance of a balanced diet Over-processing food for transport and storage Chemically treating foods during production
Micronutrient deficiencies Anemia: iron deficiency
Necessary in binding oxygen to RBCs Leads to hypoxia across the organ systems Symptoms: skin and eyes begin to yellow, low blood pressure
and muscular weakness, shortness of breath and dizziness
Treatment: eat cereal flours and milk products fortified with iron Red meats, fish, poultry, lentils Some fruits contain iron: green beans, potatoes, spinach, etc.
Micronutrient deficiencies Goitre: iodine deficiency
Iodine is necessary in thyroxine, which regulate basal metabolic rates
Swelling of the thyroid gland Can lead to swelling of the neck
○ Large goitres will result in difficulty with breathing and swallowing
Can lead to mental retardation in children
Treatment: seafood and some vegetables contain iodine Iodized salt is specifically made to prevent having an
iodine deficiency
Micronutrient deficiencies Xerophthalmia: Vitamin A deficiency
The eye fails to produce tears Leads to a dry conjunctiva, and can lead to corneal
ulceration, night blindness, or blindness from corneal damage
Treatment: Vitamin A is fat-soluble, fatty staples such as margarine can be fortified Sweet potatoes, carrots, dark leafy greens, and some
squashes and melons are high in Vitamin A
Micronutrient deficiencies Pellagra: niacin (Vitamin B3) deficiency
Niacin is a precursor to NADH and NADPH, which are essential in cell metabolism
Four main indicators: diarrhea, dementia, dermatitis, and death○ Death occurs after 4-5 years if left untreated
Kashin-Beck disease: selenium deficiency Symptoms: atrophy and degeneration of cartilage Occurs in northern Russia and China where soil is
selenium-deficient
Micronutrient deficiencies Rickets: Vitamin D, magnesium, phosphorus, or
calcium deficiency All are necessary for bone formation/maintenance Leads to bone fractures/deformity
○ Bone pain/tenderness○ Skeletal deformities and dental problems○ Muscle weakness and growth disturbances
Scurvy: ascorbic acid deficiency Ascorbic acid is necessary to synthesize collagen Symptoms: dark-spotted skin, bleeding gums, lowered
resistance to infection Can result in neuropathy or death
Micronutrient deficiencies Beriberi: thiamine (Vitamin B1) deficiency
Thiamine is used in breaking down glucose Symptoms: severe lethargy, complications to
cardiovascular, nervous, muscular, and GI systems, weight loss, swollen limbs
Kwashiorkor: protein deficiency Disease afflicting malnourished children Symptoms: swollen feet, enlarged abdomen, thinning hair,
dermatitis Afflicted individuals cannot produce antibodies and can
have lasting impacts on physical and mental growth, and can lead to death
Macronutrient deficiencies Kwashiorkor: protein deficiency
Disease afflicting malnourished children Symptoms: swollen feet, enlarged abdomen, thinning hair,
dermatitis Afflicted individuals cannot produce antibodies and can
have lasting impacts on physical and mental growth, and can lead to death
Marasmus: protein deficiency Found in infants when weaning or when a mother’s milk is
reduced Symptoms: failure to gain weight followed by weight loss
and emaciation
Solutions Add nutrients to their diets
Can be done through genetic modification to foods Provide foods rich in vitamins and minerals Fortify staple foods with micronutrients Provide nutritional supplements in a variety of forms Educate about balanced diets and the importance of
personal responsibility in dietary choices
Genetically modified foods? Genetically modified foods is controversial. People
dislike that the food is being changed genetically, as it is “unnatural”, even though they are usually beneficial: Pros
○ Products can last longer and can be grown in harsher environments/conditions
○ Products contain more nutrients, or nutrients they do not naturally contain
Cons○ Possibility of people having allergic reactions (allergenicity)○ May have different effects on human health