DNA-personalised

WHAT WORKS FOR ONE PERSON,DOES NOT NECESSARILY WORK FOR ANOTHER PERSON.GENETICS CREATES A NEW CLASS OF SKINCARE TECHNOLOGY.

We know that not every skincare product is going to suit everyone,

no matter how much the cosmetic industry tells you.

And this is why there are so many brands out there and literally

thousands of different products.

LIFE IS COMPLICATED, BUT BEAUTY DOESN’T HAVE TO BE.

idna.works

PERSONALISEDREALLY PERSONALISED

3

No more guesswork, no more buying products that feel like they might help.

THERE IS NO ONE-SIZE FITS ALL FOR OUR CUSTOMERS.

We replaced skincare guesswork with genetically-designed cosmeceuticals OTC (over the counter)

and nutricosmetics supplements.

THE RIGHT INGREDIENTS, IN THE RIGHT FORMULATIONS, IN THE RIGHT ORDER.

Science of [DNA] f(x)™ proprietory statistical algorithms grows in accuracy day by day with [iD]DNA® growing

sample set. 2014 population for Science of [DNA] f(x)™ is about more than 20.000 DNA population wide

samples stored entirely in-house, making [iD]DNA® ultra-custom biologically active treatment leading

the way in wellness personal genetics predictions.

Science of [DNA] f(x)™ = GENES VS LIFESTYLE

GENETICS VS

LIFESTYLE

HOW MUCH OF YOUR SKIN AGING CAN YOU ACTUALLY CONTROL?

While genetics do play a large role in how quickly you will age, recent research has started

to show that the habits you develop and choices you make throughout life might be even more

telling, so with your genetically customised ANTI-AGING plan you have control over

how your skin ages.

[iD]DNA® ultra-custom IS SMART SCIENCE

INDIVIDUAL TREATMENT PLANS

THAT PERFORM AS THEY CLAIM

A SIMPLE, ADVANCED,

PERSONALISED TREATMENT PLAN

SUITED FOR TODAY BUSY LIVES

A PERSONALISEDTREATMENT PLAN

4 5[iD]DNA®

ultra-custom

WE FOCUS ON GENES VS LIFESTYLE: How much of your skin aging can you control?

IF YOU WANT TO STAY YOUNG WITH AGE,

YOU NEED TO KNOW YOUR GENE-EXPRESSION AGE.

LET’S DISCOVER YOUR SKIN IDENTITY!

FIGHT YOUR EXPIRATION DATE

6 7[iD]DNA®

ultra-custom

Aging is a gradual, irreversible process that occurs

as a number of changes in the appearance

and texture of the different skin structures.

Your DNA is the code containing all the information

necessary to our cells to develop over time

[iD]DNA® IS THE FIRST DNA-PERSONALISED

ANTI-AGING TREATMENT IN THE WORLD

THE SCIENTIFIC APPROACH

DNA CODE

IS THE KEY

8 9[iD]DNA®

ultra-custom

LET’S FOCUS ON GENES VS LIFESTYLE:How much of your aging can you really control?

STAY YOUNG WITH AGE!DO YOU REALLY KNOW IF YOU’RE YOUNGER

OR OLDER THAN YOUR BIRTH-CERTIFICATE AGE?

DNAge

The first DNA-personalised prescription

strength treatment to help you fight

your SKIN AGING concerns on your

GENE-EXPRESSION AGE.

DNADiet

The DNA-personalised weight loss

management plan to help you manage

successfully your weight on your

GENE-EXPRESSION EATING PROFILE.

DNACell

The first DNA-personalised CELLULITE

treatment to help you fight the severity

stage of your GENE-EXPRESSION

CELLULITE GRADE.

DNAHair

The DNA-personalised HAIR LOSS

treatment to help you fight your

GENE-EXPRESSION HAIR LOSS STAGE.

DNASport

The first DNA-personalised SPORT

PERFORMANCE optimisation plan to

help you choose the sport that best

suits you and improve your performances

to your maximum potential.

TURN BACKTHE CLOCK

10 11[iD]DNA®

ultra-custom

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3

4

1

IT’S TIME FOR YOUR TREATMENTTO GET PERSONAL

ONE-SIZE DOES FIT YOUULTRA-CUSTOM

YOUR DNA TESTDo you want real results?

[iD]DNA® ultra-custom, the first and only genetically-guided

skincare treatment in the world.

Specific deficits.

Individual benefits.

Precision skincare treatments.

[iD]DNA® CHALLENGE Your follow up for evidence-based performance.

[iD]DNA® technology measures your results and how much you could improve more...

Each [iD]DNA® treatment is engineered on scientific studies (in vivo) clinical efficacy

terms of application and parameterised to individual GENES vs LIFESTYLE guidance.

[iD]DNA® ASSESSMENT

As you’ve done your simple DNA assessment, you’re ready to discover research-grade lifelong

scientific remarks and suggestions.

[iD]DNA® GENETIC REPORT

This [iD] GUIDE comes with your [iD] GENETIC REPORT.

Ask your consultant to fully understand any insight and connect to idna.works to create your

[iD]DNA® 15 days-trial of your [iD]DNA® ultra-custom foundation treatment.

[iD]DNA® ULTRA-CUSTOM BIOLOGICALLY ACTIVE TREATMENTYour very individual treatment: the right ingredients, intensity, dose, dosage and the right order

depends on your [iD]DNA® score, a benchmark of individual GENES vs LIFESTYLE expression age.

THE TRUTH[iD]DNA® is the only concept to accept the challenge

of proving on you the effectiveness of your personalised

treatment. Change perspective, focus on GENES vs LIFESTYLE

to calculate your gene-expression age (younger or older

than your birth-certificate age?)

REAL SCIENCE. REAL RESULTS.

GET RESULTSForget trials and errors. Get results now!

Your [iD]DNA® ultra-custom treatment plan will provide you:

• THE RIGHT INGREDIENTS

• THE RIGHT FORMULATIONS

• THE RIGHT ORDER

Prescription strength. With no need of prescription.

DNA-PERSONALISATIONYou’re unique and your beauty is unique, only a personalised

treatment will work for you.

[iD]DNA® ultra-custom is the luxury of a customised

science-based skincare treatment made specifically for you.

Because your genes don’t lie.

[iD]DNA®

YOUR IDENTITY

[iD]DNA®

THE CONCEPT

TREATMENT-PACK

60 days 2 months

120 days 4 months

120 days 6 months

240 days 8 months

CONCERNS

Anti-Aging

Anti-Aging • Cellulite Treatment • Weight Loss Management • Body Contouring

Cellulite Treatment • Weight Loss Management • Hair Loss Treatment

Hair Loss Treatment

12 13[iD]DNA®

ultra-custom

YOUR [iD] GENETIC PROFILE

Gene Cromosome Genotype

FLG Filaggrin 1q21.3 II

MMP3 Stromelysin-1 also called matrix metalloproteinase 3 11q22.2 5A/5A

ELN Elastin 7q11.23 -/A

PPARG Cellular receptor PPARG 3p25.2 CC

SOD Superoxide dismutase 2 6q25.3 TC

GSTT Glutathione S-transferase T-1 22q11.23 INS

GSTM Glutathione S-transferase M-1 1p13.3 DEL

NOS3 Endothelial nitric oxide synthase 7q36.1 5/5

TNFα Endothelial nitric oxide synthase α 6p21.33 GG

EMILIN1 Emilin 1 2p23.3 CG

COL3a1 Collagen 2q32.2 GG

GPX Glutathione peroxidase 3p21.31 CT

HAS1 Hyaluronic acid synthetase 19q13.41 GG

GENETIC EVALUATION DECODING KEY

OPTIMAL genetic function

ALTERED genetic function

ADVERSE genetic function

GENETICAL GUIDANCE FOR YOUR TREATMENT PLAN

The genetic variant analyzed predispose to a reduced state of hydration. Your skin is less able to

retain water, appearing less tonic. Your genetics also expose skin to the risk of developing intense

dryness phenomena and loss of relaxing capacity.

To counter the adverse effects to which your genetics predispose you it is important to follow few

recommendations that may be useful to improve your state of hydration, delaying the onset of

aging phenomena and helping skin remain firmer for longer.

Given that intense exposure to UV rays coming from the sun may cause skin damage, it is

recommendable to use sunscreens and avoid the hours of maximum intensity. UV rays are also

emitted from sunlamps used in tanning treatments.

The best international scientific references recommend you a corrective treatment based on these

suggestions.

Pentavitin® is a 100%-natural ingredient, made in Switzerland, ECOCERT, to feel deep hydration

for 72 hours. Clinically tested to effectively stimulate genes that play a key role in skin barrier

improvement.*

Moreover, to improve the aspects analyzed in this area, the treatment should also include

hyaluronic acid, sodium hyaluronate crosspolymer, biosaccharide gum-1.

Strictly following the treatment plan that you can create with this genetical guidance, the [iD]

DNA index® for SKIN MOISTURISATION will improve up to 36%.

VISIBLE EFFECTS BIOLOGICAL EFFECTS

POSSIBLE SAGGING SKIN IN THE FORM OF UNSIGHTLY WRINKLES

OR EXPRESSION LINES

POSSIBLE PREDISPOSITION TO HYPERSENSITIVE AND REACTIVE

SKIN

INSUFFICIENT INTAKE OF NITRIC OXIDE

POSSIBLE MINOR DEFENSE AND REGENERATION CAPABILITIES

AGAINST EXOGENOUS STIMULI

POSSIBLE MINOR FIRMNESS OF THE DERMIS

AREA [2]

*all clinical data refers to in vitro ed in vivo clinical studies for claim substantiations by the manufacturers, from their product dossier. Data used for internal training on treatment

functionalities and outcomes presentation. Available evidence documentation on request.

GENE-EXPRESSION AGE

VISIBLE EFFECTS BIOLOGICAL EFFECTS

soft skin[1]

balanced tone and elasticity maintenance[1]

potential premature skin aging[2]

possible loss of subcutaneous fat on the face resulting in the

appearance of wrinkles and skin folds[2]

soft and shiny skin[3]

proper hydration[3]

possible sagging skin in the form of unsightly wrinkles or expression

lines[6]

possible predisposition to hypersensitive and reactive skin[6]

unaltered hydro-lipid film barrier protection[4]

good protection against free radicals damage and oxidative stress[5]

effective elimination of toxic substances[5]

correct cell regeneration[1]

protection against external agents[1]

maintenance of firmness[1]

possible alteration in the production of pro-inflammatory

cytokines[2]

risk of developing flogistic phenomena[2]

fair hydrating ability[3]

normal ability to retain water[3]

insufficient intake of nitric oxide[6]

possible minor defense and regeneration capabilities against

exogenous stimuli[6]

possible minor firmness of the dermis[6]

[ ] brackets indicates the number of the area in which the effect of which it refers.

100 OPTIMAL + + Base level FOLLOW UP -- recommended

0 MAXIMUM RISK - - MAXIMUM SUPPORT recommended + +

Your [iD] DNA index*

54%Determined upon the basis of genetic testing combined with your lifestyle self-optimisation

[1] Wrinkling (firmness + elasticity) …………………………………………………………………………………………………………………… medium risk

[2] Moisturisation (hyaluronic acid potential) …………………………………………………………………………………………… increased risk

[3] Skin Hydration (hydro-lipid film) …………………………………………………………………………………………………………… increased risk

[4] Free radicals damage …………………………………………………………………………………………………………… medium risk

[5] Regeneration (vascolarisation + oxygenation) ………………………………………………………………… reduced risk

[6] Sensivity + Inflammation ………………………………………………………………………………………………………………………………………… reduced risk

*[iD] DNA® index is the benchmark of the Swiss patent pending concept [iD] DNA® ultra-

custom, showing your scoring in terms of GENES vs. LIFESTYLE. [iD] DNA® index is created on

your genetics, balanced by the interference of individual habits by anamnestic self-assessment.

Your area [iD] DNA® index will be processed by the Science of [DNA] f(x)™ to get your

recommended treatment plan.

The scale [iD] DNA® index ranges from 100 to 0.

SNP DETAIL

Gene

HAS1 Hyaluronic acid synthetase

Hyaluronic acid bestows skin the particular properties of plasticity, strength, and shape retention thanks to its moisturizing ability. In fact, it is able to bind a large number of molecules of water, ensuring greater skin hydration. The presence of a polymorphism at this gene level, may contribute to a lesser state of hydration of skin.

Your DNA test highlighted the presence of the disadvantageous GG variant which renders the HAS1 enzyme less functioning. The reduction of hyaluronic acid which follows causes skin to appear less hydrated, as it retains less water molecules.

Cromosome Genotype

18 GG

Locus Telomere localisation

18q13.41 13.41

AREA [2]

DNA-RECOMMENDED ACTIVE INGREDIENTS

CLINICAL PRESCRIPTION

TOPICAL INGREDIENTS NUTRITIONAL INGREDIENTS

ACETIL HEXAPEPTIDE-50

CAPRYLIC/CAPRIC TRIGLYCERIDE (AND) TEPRENONE

CERAMIDE 3 (AND) CERAMIDE 6 II (AND) CERAMIDE 1 (AND)

PHYTOSPHINGOSINE

CHRYSANTHUS BULB EXTRACT

COPPER TRIPEPTIDE-1

DIMETHILMETHOXY CHROMANOL

GLYCOPROTEINS, GLUTAMIC ACID, VALINE, THREONINE

SOY ISOFLAVONES

ISOTHIOCYANATES

L-ASCORBIC ACID 15%

OZONIZED OLEIC ACID

PHYTOCELLTEC MALUS DOMESTICA

PROANTHOCYANIDIN PHOSPOLIPID COMPLEX

TRIPEPTIDE-10 CITRULLINE

HYALURONIC ACID

SODIUM HYALURONATE CROSSPOLYMER

BIOSACCHARIDE GUM-1

SACCARINE ISOMERATE

DMAE-DIMETHYLAMINOETHANOL

HYDROLIZED RICE PROTEIN, GLYCINE SOJA PROTEIN,

SUPEROXIDE DISMUTASE

OLIGOPEPTIDE-68

PALMYTOL TRIPEPTIDE-5

SUPEROXIDE DISMUTASE

ACETYL TETRAPEPTIDE PLATINIUM

NIACINAMIDE

POLLEN EXTRACT (AND) GLYCINE SOJA

GLYCINE SOYA PROTEIN (AND) SUPEROXIDE DISMUTASE (AND)

SODIUM DEXTRAN SULFATE

OLIGOPEPTIDE-34

ACETYL DECAPEPTIDE-3

ALPHA-LIPOIC ACID

ELLAGIC ACID

NIACIN (VITAMIN B3)

SUPEROXIDE DISMUTASIS 560 UI

VITAMIN C

VITAMIN D

BIOTIN (VITAMIN H)

RECOMMENDED BIOACTIVE INGREDIENTS

ACETIL HEXAPEPTIDE-50

Juveleven® is the guardian of your genomic integrity, by protecting and repairing DNA damage and delays senescence: cell rejuvenation by over 10 years*. Key element in preserving the vital code. Reverts senescence in fibroblasts.

ACETYL DECAPEPTIDE-3

CG-Rejuline® is a bio-mimetic complex, which prevents the formation of expression lines and wrinkles, promoting active cell regeneration. It's a new technology that revitalise and regenerate your skin. CG-Rejuline® strengthens elasticity and improves skin quality, inducing the synthesis of collagen type I and elastin.

ACETYL GLUTAMYL HEPTAPEPTIDE-1

SNAP-8® is a bio-mimetic epta-peptide safe hi-tech alternative solution to Botox®. Bye, bye Botox®: SNAP-8® reduces wrinkles up to - 63%, after 28 days application*, without needles. Maximum efficacy for frown lines, crow's feet, expression wrinkles.

ACETYL HEXAPEPTIDE-8

Argireline® is a bio-mimetic hexapeptide, specific for the correction of eye contour concerns. It relieves congestion in the eye area; it is active against the formation of edema (swelling) caused by compromised hemodynamics, against faulty lymphatic circulation, or against high capillary permeability. This peptide regulates the loss of skin elasticity and the risk of formation of bags under the eyes. It also reduces dark circles. Clinical tests show that it reduces bags under the eyes in only 14 days*.

ACETYL TETRAPEPTIDE PLATINIUM

Platinum peptide is a bioconjugated high-tech nanoparticle clinically tested for +280% collagen III synthesis increase, +250% collagen I synthesis increase, -61% wrinkles reduction, +47% skin elasticity, +33% skin hydration, after just 30 days application*.

ACETYL TETRAPEPTIDE-2

Uplevity® hi-tech peptide counteract the force of gravity, by increasing collagen and functional elastin synthesis, and cellular support. It provides a better structure to the dermis improving the quality of mature skin. Clinically tested for +47,3% collagen I synthesis, +21,7% elastin synthesis. Uplevity® peptide further contributes to skin firmness by overexpressing genes involved in cellular cohesion, that are the interface between the actin cytoskeleton and extracellular matrix (ECM)*.

The ultra-personalized treatment plan on your genetic identity

[iD] DNA index [iD] DNA index TARGET Your DNA reccommends

59% 69%

The genetic test highlighted a reduced susceptibility to chrono-aging.

This means that your skin properly protects against external agents and will

tend to remain more supple, firm and soft.

[iD] DNA index [iD] DNA index TARGET Your DNA reccommends

24% 36%

The genetic variant analyzed predispose to a reduced state of hydration. Your

skin is less able to retain water, appearing less tonic. Your genetics also expose

skin to the risk of developing intense dryness phenomena and loss of relaxing

capacity.

[iD] DNA index [iD] DNA index TARGET Your DNA reccommends

30% 35%

The genetic variant we detected predisposes to an increased accumulation of

adipose tissue.

Therefore you may experience alterations in the lipid film with typical

manifestations of oily skin and acne.

[1] Wrinkling (firmness + elasticity) …………………………………………………………………………………………………………………… medium risk

[2] Moisturisation (hyaluronic acid potential) …………………………………………………………………………………… increased risk

[3] Skin Hydration (hydro-lipid film) …………………………………………………………………………………………………………………… increased risk

SCIENTIFIC REFERENCES

1. The important role of stratum corneum lipids for the cutaneous barrier function. van Smeden J, Janssens M, Gooris GS, Bouwstra JA. Biochim

Biophys Acta. 2013 Nov 16. doi:pii: S1388-1981(13)00248-5. 10.1016/j.bbalip.2013.11.006. 2. Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin.Uitto J.Clin Geriatr Med. 1989 Feb;5(1):127-

47. Review. 3. Effect of the sun on visible clinical signs of aging in Caucasian skin. Flament F, Bazin R, Laquieze S, Rubert V, Simonpietri E, Piot B. Clin Cosmet

Investig Dermatol. 2013 Sep 27;6:221-32. doi: 10.2147/CCID.S44686. 4. 5,7-Dimethoxyflavone, an activator of PPARα/γ, inhibits UVB-induced MMP expression in human skin fibroblast cells.Kim JK, Mun S, Kim MS,

Kim MB, Sa BK, Hwang JK.Exp Dermatol. 2012 Mar;21(3):211-6. doi: 10.1111/j.1600-0625.2011.01435.x. 5. Peroxisomes in dermatology. Part I.Smith KJ, Dipreta E, Skelton H.J Cutan Med Surg. 2001 May-Jun;5(3):231-43. Epub 2001 May 17. Review. 6. The role of manganese superoxide dismutase in skin aging. Treiber N, Maity P, Singh K, Ferchiu F, Wlaschek M, Scharffetter-Kochanek

K.Dermatoendocrinol. 2012 Jul 1;4(3):232-5. doi: 10.4161/derm.21819. 7. Effects of cigarette smoke extracts on the growth and senescence of skin fibroblasts in vitro. Yang GY, Zhang CL, Liu XC, Qian G, Deng DQ.Int J

Biol Sci. 2013 Jun 28;9(6):613-23. doi: 10.7150/ijbs.6162. Print 2013. 8. Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin. Bruning RS,

Santhanam L, Stanhewicz AE, Smith CJ, Berkowitz DE, Kenney WL, Holowatz LA. J Appl Physiol (1985). 2012 Jun;112(12):2019-26. doi: 10.1152/japplphysiol.01354.2011. Epub 2012 Apr 12.

9. Nitric oxide function in the skin. Cals-Grierson MM, Ormerod AD.Nitric Oxide. 2004 Jun;10(4):179-93. Review. 10. Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male

population.Park JE, Lee WH, Hwang TH, Chu JA, Kim S, Choi YH, Kim JS, Kim DK, Lee SH, Hong KP, Seo JD, Lee WR.Korean J Intern Med. 2000 Jan;15(1):65-70.

11. IL-11, IL-1α, IL-6, and TNF-α are induced by solar radiation in vitro and may be involved in facial subcutaneous fat loss in vivo. Li WH, Pappas A, Zhang L, Ruvolo E, Cavender D. J Dermatol Sci. 2013 Jul;71(1):58-66. doi: 10.1016/j.jdermsci.2013.03.009. Epub 2013 Apr 10.

12. Factors of skin ageing share common mechanisms. Giacomoni PU, Rein G.Biogerontology. 2001;2(4):219-29. Review. 13. Effect of the sun on visible clinical signs of aging in Caucasian skin. Flament F, Bazin R, Laquieze S, Rubert V, Simonpietri E, Piot B. Clin Cosmet

Investig Dermatol. 2013 Sep 27;6:221-32. doi: 10.2147/CCID.S44686. 14. Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic 15. irritant contact dermatitis: a case–control study C.M. de Jongh,*_ L. Khrenova,_ M.M. Verberk,* F. Calkoen,* F.J.H. van Dijk,* H. Voss,_ S.M.

John_ and S. Kezic**Coronel Institute of Occupational Health, Academic Medical Centre, University of Amsterdam, P.O. Box 22700, Amsterdam 1100 DE, the Netherlands_National Poisons Information Centre, National Institute for Public Health and the Environment, Bilthoven, the Netherlands_Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabru¨ck, Osnabru¨ck, Germany

16. Matrix metalloproteinase-3 genotype contributes to age-related aortic stiffening through modulation of gene and protein expression.Medley TL, Kingwell BA, Gatzka CD, Pillay P, Cole TJ.Circ Res. 2003 Jun 13;92(11):1254-61. Epub 2003 May 15.

17. Molecular pathology of the elastic fibers. Christiano AM, Uitto J. J Invest Dermatol. 1994 Nov;103(5 Suppl):53S-57S. Review. 18. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. Bastaki M, Huen K, Manzanillo P,

Chande N, Chen C, Balmes JR, Tager IB, Holland N Division of Environmental Health Sciences, School of Public Health, University of California-Berkeley, Berkeley, CA 94608, USA.

19. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. 20. Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, Balmes JR, Tager IB, Holland N. Division of Environmental Health Sciences, School of

Public Health, University of California-Berkeley, Berkeley, CA 94608, USA. Arch Dermatol Res. 2011 Aug;303(6):445-9. doi: 10.1007/s00403-011-1129-9. Epub 2011 Feb 4.

GENETICAL GUIDANCE FOR YOUR TREATMENT PLAN

The genetic variant analyzed predispose to a reduced state of hydration. Your skin is less able to

retain water, appearing less tonic. Your genetics also expose skin to the risk of developing intense

dryness phenomena and loss of relaxing capacity.

To counter the adverse effects to which your genetics predispose you it is important to follow few

recommendations that may be useful to improve your state of hydration, delaying the onset of

aging phenomena and helping skin remain firmer for longer.

Given that intense exposure to UV rays coming from the sun may cause skin damage, it is

recommendable to use sunscreens and avoid the hours of maximum intensity. UV rays are also

emitted from sunlamps used in tanning treatments.

The best international scientific references recommend you a corrective treatment based on these

suggestions.

Pentavitin® is a 100%-natural ingredient, made in Switzerland, ECOCERT, to feel deep hydration

for 72 hours. Clinically tested to effectively stimulate genes that play a key role in skin barrier

improvement.*

Moreover, to improve the aspects analyzed in this area, the treatment should also include

hyaluronic acid, sodium hyaluronate crosspolymer, biosaccharide gum-1.

Strictly following the treatment plan that you can create with this genetical guidance, the [iD]

DNA index® for SKIN MOISTURISATION will improve up to 36%.

VISIBLE EFFECTS BIOLOGICAL EFFECTS

POSSIBLE SAGGING SKIN IN THE FORM OF UNSIGHTLY WRINKLES

OR EXPRESSION LINES

POSSIBLE PREDISPOSITION TO HYPERSENSITIVE AND REACTIVE

SKIN

INSUFFICIENT INTAKE OF NITRIC OXIDE

POSSIBLE MINOR DEFENSE AND REGENERATION CAPABILITIES

AGAINST EXOGENOUS STIMULI

POSSIBLE MINOR FIRMNESS OF THE DERMIS

AREA [2]

*all clinical data refers to in vitro ed in vivo clinical studies for claim substantiations by the manufacturers, from their product dossier. Data used for internal training on treatment

functionalities and outcomes presentation. Available evidence documentation on request.

YOUR [iD] GENETIC REPORTHOW TO READ YOUR [iD]

[iD]DNA®

REPORT

1 5

3 7

2 6

4 8

Your [iD] starts with your [iD]DNA® score.

All the relevant areas in terms of biological

systems affecting the concerns are detailed

with visible and biological (internal) effects.

Rather than simply focus on an analysis

of your skin health, your [iD]DNA® provides

active ingredients recommendations, directly

related to your individual requirements.

In your [iD] GENETIC REPORT, you find:

• GENETIC remarks

• LIFESTYLE recommendations

• EXERCISE suggestions

• NUTRITION recommendation

• ACTIVE INGREDIENTS that suits most your skin.

[iD]DNA® reveals you the improvement you

can experience following your [iD]DNA®

ultra-custom biologically active treatment.

Follow the suggestions to get results!

This is your genetic profile. All the SNPs

involved are presented in detail with your

genotype and an easy-to-understand

positive/negative rating.

Our scientific references library is able

to define the relationship between

the active ingredients and the different

genes variations of your genetic profile.

The scientific foundation uncovers your

skin potential. Real science application

reveals your human genomic profile, for

more accurately predicting your treatment.

[iD]DNA® is scientifically backed

by third parties scientific references,

you can find and check at the end of your

[iD] GENETIC REPORT.

14 15[iD]DNA®

ultra-custom

IN&OUT BENEFITS: + CLINIAge NUTRICOSMETICA DNA-personalised and professional-optimized skin care system designed to work in sinergy

at the cellular level to help improve and preserve the youthful look and vitality of your skin.

• PROTECT SKIN STEM CELLS

• REPAIR DNA

• SMOOTH OUT WRINKLES FROM THE INSIDE OUT

• PROTECT THE YOUTHFUL LOOK AND VITALITY OF YOUR SKIN

FUNCTION

AGE-DEFYING

PRECISION

CORRECTIVE

INVERTAGE

AVERAGE DURATIONS

60 days 2 months treatment

60/120 days 2-4 months treatment

120 days 4 months treatment

240 days 6 months treatment

IN&OUT

SUGGESTED

OPTIONAL

SUGGESTED

MANDATORY

Just insert your [iD] code to find out you DNA-personalised treatment:

PREMIUM SWISS SKIN CARE TECHNOLOGY THE SCIENCE OF AGELESS SKIN: 3+5 REPAIRS, REJUVENATES AND TRANSFORMS SKIN.

AGE DEFYING

SKINCARE

CLEANSE

FOUNDATION TREATMENT: CLINILift+ PRESCRIPTION STRENGTH: booster

PRECISION TREATMENT: CLINIUV A-B

CLEANSE

FOUNDATION TREATMENT: CLINICo2A, CLINICo2B

FOUNDATION TREATMENT: CLINIGf DNA+ PRESCRIPTION STRENGTH: booster

PRECISION TREATMENT: CLINIEye_5

INTENSIVE CARE: CLINIFace (Eye) therapy

33

22

11

4

5

every 2 weeks

every 10 weeks

FORGET TRIALS AND ERRORSGET RESULTS NOW!

[iD]DNA® ultra-custom represents an unprecedented approach to skin care.

Your personalized skin care program started with your [iD]DNA® test.

• BY TAKING THIS SIMPLE TEST, you unlock the secrets to your skin’s genetic strengths

and weaknesses.

• BY TESTING YOUR DNA, now you can scientifically select the professional strength

treatment that will most benefit your skin’s beauty and health.

ENJOY YOUR 15 DAYS DNA-PERSONALIZED

FOUNDATION TREATMENT TODAY!

AFTER YOUR FIRST 15 DAYS TREATMENT, TO GET YOUR FULL DNA-PERSONALISED TREATMENT:

connect right now to idna.works

just enter your [iD]code

select the signs of aging you want to fight in YOU+online adjustement

It’s easier than you think and it takes only 5 minutes.

2

1

3

YOUR [iD]DNA®

idna.works

idna.works

16 17[iD]DNA®

ultra-custom

ALL THE ACTIVE INGREDIENTS ARE SELECTED TO ENSURE

AN UNPRECEDENTED COSMETOGENOMICS EFFICACY:

EXTENDS CELL VITALITY AND LONGEVITYReactivating cells regeneration and renewal in the basal layer of epidermis,

leading to a higher keratinocyte production. The epidermal tissue becomes

thicker, denser and more resistant to external aggressions.

STRENGTHENS THE EXTRACELLULAR MATRIXRestoring the dermo-epidermal junction and stimulates fibroblasts achieving

an increase in the quality and amount of collagen and elastin.

The skin recovers elasticity and firmness, facial oval has a new sustain

and expression lines decrease substantially.

CELL REGENERATION AND REPAIRProtecting and reactivating your own dermoepidermal stem cells, with

selected biomimetic peptides and plant stem cells extracts, strengthening

the connective tissue structure an improving skin quality and texture.

INTELLIGENT ANTIOXIDANT ACTIONNeutralising free radicals contributing to improve the skin’s defence capacity

and delays the skin aging process.

HIGH-TECH COSMETIC ENGINEERINGEncapsulating biomimetic peptides, functional ingredients, plant stem cells

in release biovectors to transport them and act in the innermost skin.

They mimics, in their composition and structure, the cell membrane,

increasing the penetration and diffusion levels.

CLINICare® cliniceuticals is our brand of unique formulations

for genetically-guided individual treatments, built just for the [iD]DNA®

ultra-custom concept.

+ PATENTED SCIENCE

+ PROPRIETARY FORMULATIONS

Proprietary formulations

Scientifically formulated from researchers for targeted efficacy

CLINICare®

CLINICEUTICALS

18 19[iD]DNA®

ultra-custom

COMBINATION THERAPY

DNA ASSESSMENT

ACTIVE TREATMENTScliniceuticals

FOLLOW UPcliniceuticals

To make you sure about getting the best results of your [iD]DNA® ultra-custom biologically active

treatment, we put your smartphone in charge as your personal assistant:

check your [iD]DNA® ultra-custom treatment plan:

THE RIGHT INGREDIENTS

THE RIGHT FORMULATIONS

THE RIGHT ORDER

[iD]DNA® ultra-custom app will remind you all your treatments with your personalized dose,

at the right moment.

COLLECTIONS

ANTI-WRINKLE

TIGHTEN & LIFT

REJUVENATION

PRECISIONprofessional strength

ACTIVE INGREDIENTS

TRYLAGEN® functional

SNAP-8® peptide

MATRIXYL-3000® peptide

JUVELEVEN® peptide

UPLEVITY® peptide

RELISTASE® peptide

DMAE

EGF

COPPER-peptide 1

PLATINUM-peptide

REJULINE® peptide

PREREGEN® functional

ARGIRELINE® peptide

BONT-peptide®

SYN-AKE® peptide

SENESTEM® functional

DERMCOM® functional

BENEFITS

• diminishes length and depth

of lines and wrinkles

• stimulates collagen regeneration

for healthy, younger looking skin

• tightens and firms skin

• restores elastin to create lift

and contour

• intelligent antioxidant action

• free radicals and sun damage

protection, DNA repair

• moisturisation and skin protection

• renew skin smoothness

• refine skin texture

• reveal skin radiance

• revitalize skin tone

• intelligent antioxidant action

• correct eye bags, puffy eyes

SUSTAINABLE SAFE HI-TECH

COSMECEUTICALS

PARABEN

PHTALATE

SLS

COMEDOGENIC

ANIMAL INGREDIENTS

ARTIFICIAL COLORSNOFREE

AGE-DEFYING

SKINCARE

SCIENCE OF [DNA]

WHAT NEXT?

YOUR TREATMENT AT YOUR FINGERTIPS!

SEE THE REAL RESULTS![iD]DNA® CHALLENGE

When you’re about to end your treatment, your [iD]DNA® follow up WILL CHECK YOUR REAL

IMPROVEMENT to show how your treatment has really worked.

20 21[iD]DNA®

ultra-custom

CHRONO-AGING depends on genetic factors

specific to each of us. It begins after the age

of 25, and it may be visibly manifested from

40 years onwards.

We observe at the level of the epidermis a lower

ability of cells to regenerate with consequent

thinning of the skin layer.

Even the skin glands are gradually reducing

their activity, resulting in reduced production

of sebum and increased skin dryness.

Aging is also induced by environmental factors

such as pollution, stress, unbalanced diets

or exposure to irritants and harmful substances

such as cigarette smoke.

in particular, a very important role is played

by PHOTO-AGING, which is a chronic and

premature aging of the skin due to prolonged

exposure to sunlight and to the formation

of free radicals.

Today, aging is worsen by TECHNOLOGICAL-

AGING, the aging process caused

by electromagnetic waves of iphones, mobile

phones, ipads,computers, constantly attacking

skin moisturisation and hydration barrier.

With the passage of time, the skin may experience skin aging, id est

a series of physiological changes that lead to an increased occurrence

of micro-wrinkles, loss of elasticity, and skin dryness.

These changes are mainly due to two parallel events: CHRONOLOGICAL AGING and ENVIRONMENTAL FACTORS.

WRINKLING Firmness + Elasticity

MOISTURISATION Hyaluronic Acid

Potential

HYDRATION BARRIERHydrolipid Film

REGENERATIONVascolarisation +

Oxigenation

SENSITIVITY + INFLAMMATION

BEFORE AFTER

FREE RADICALSDAMAGE

FLG1

1q21,3

MMP311

11q22,2

ELN7

7q11,23

EMILIN12

2p23,3

COL3a12q32,2

SOD6

6q25,3

GSTM1

1p13,3

GSTT22

22q11,23

GPX3

3p21.31

LET’S CALCULATE YOUR GENE-EXPRESSION AGEAre you younger or older than your birth-certificate age?

Everyone’s skin is unique, as are their fingerprints and genetic code.

Your biological and emotional life can be read on your skin.

Your skin talks your story.

HAS119

19q13,41

PPARG3

3p25,2

NOS37

7q36,1

TNFα6

6q21,33

YOUR DNAge [iD]

Science of [DNA] f(x)™ = [(1+1) x (8+324+1) x 3)] + 2 = 6.291.512 INDIVIDUAL TREATMENT COMBINATIONS22 23[iD]DNA®

ultra-custom

Nutrigenetics is a new discipline

that seeks to explain how

the substances we ingest

are metabolized and used,

based on our genes.

The study of DNA makes it possible

to determine the exact amount

of nutrients that each of us requires

and the reaction you’ve to different

dietary components.

DNADiet IS NOT A DIETARY PLAN

DNADiet PROVIDES SPECIFIC NUTRITIONAL RECOMMENDATIONS FROM YOUR DNA

No more dieting, but healthy eating: know yourself to take care of yourself

CAN YOU EAT WHAT YOU LIKE, MANAGING SUCCESS-FULLY YOUR WEIGHT?It is scientifically proven that good nutrition can improve the state

of your health, reducing the risk of many diseases, as well

as chronic ones. But there are no dietary rules that are the same

for everyone, just as there are no diets that work for everyone.

FTO16

16q12,2

ACE17

17q23.3

IL101

16q12,2

TNFα6

6q21,33

CYP1A216

15q24.1

VDR12

12q13.11

APOC311

11q23,3

LPL8

8p21,3

GSTM1

1p13.3

GSTT22

22q11.23

CYP1A216

15q24.1

SOD6

6q25,3

MTHFR1

1p36.22

LCT2

2q21.3

VDR12

12q13.11

DQ2/86

6p21,32

ACE17

17q23.3

BODY FAT LEVELS AND SUGGESTED EXERCISE

INFLAMMATORYRESPONSE

SENSITIVITYTO CAFFEINE

LIPIDSMETABOLISM

GLYCEMIC LEVELS +CABOHYDRATESMETABOLISM

B VITAMINSMETABOLISM

LACTOSEINTOLERANCE

D VITAMINS METABOLISMBone Health

PREDISPOSITION TO CELIAC DISEASEGluten Tolerance

SENSITIVITY TO SALTHypertension

DETOXIFICATIONABILITY

ACE17

17q23.3

PPARG3

3p25,2

TCF7L210

10q25.2-3

YOUR DNADiet [iD]

With this test we have analyzed some variations present in

16 GENES, which are involved in the metabolism of foods,

and play an important role in determining your body health:

• FATS ABSORBTION

• LIPIDS AND GLUCOSE METABOLISM

• FATS MOBILIZATION AND LIPIDS METABOLISM

• FATS REGULATION AND BREAKDOWN OF FAT STORES

• FATS METABOLISM AND BODY FAT LOSS

• BONES HEALTH

• SENSITIVITY TO CAFFEINE, ALCOHOL, SALT HYPERTENSION

Science of [DNA] f(x)™ = [(1+1) x (1+224+3) x 3] = 127.800 INDIVIDUAL TREATMENT COMBINATIONS24 25[iD]DNA®

ultra-custom

The macroscopic appearance of cellulite is a result of alterations of the connective tissue,

which bestow typically spongy and riddled features on the outer layer of skin,

commonly known as orange peel. But not all cellulite is created equal.

Cellulite is characterized by relief alterations of the skin surface, which give the skin

an orange peel, cottage cheese, or mattress appearance.

Flaccidity, laxity, or sagging of the skin further aggravates relief alterations.

Scientific studies have shown that this type of imperfection may arise in very thin people,

and that, on the contrary, some people who are overweight may not be affected by it.

These data suggested that cellulite is not only linked to incorrect diet and lifestyle, but that

genetic factors may also somehow be involved.

EACH ONE OF US IS DIFFERENT, AND THESE DIFFERENCES ARE DUE,AT LEAST IN PART, TO OUR DNA THAT WITH ITS MINOR VARIATIONSALLOWS US TO DIFFERENTIATE IN AT LEAST 3 RESPECTS:

LET’S CALCULATE YOUR GENE-EXPRESSION CELLULITE GRADEAlthough cellulite is often associated a lack of fitness,

ABOUT 90% OF WOMEN, including thin and athletic morphotypes,

experiment some kind of cellulite.

ACE17

17q23.3

HIF1α14

14q23.2

CYP1A27

7q36,1

ESR16

6p25.1

IL-1a2

2q13

HORMONAL FACTOR AND GENETIC PREDISPOSITION

CELLULAR AND TISSUE INFLAMMATION

OXYGENATION, VASODILATATION AND ALTERATION OF MICROCIRCULATION

YOUR DNACell [iD]

HORMONAL FACTORSHave a dominant role in the formation of cellulite.

INFLAMMATION Contributes to increased levels of fluid in tissues.

OXYGENATION-VASODILATION-ALTERATION

OF THE MICROCIRCULATION

Some genes may be associated with alterations of the venous system causing a slowing down of blood flow and stagnation of fluids in the spaces between cells.

2

1

3

Science of [DNA] f(x)™ = [2 x (144+3) x 3] = 230.514 INDIVIDUAL TREATMENT COMBINATIONS26 27[iD]DNA®

ultra-custom

Your genes play a key role in biological systems,

like muscle formation, oxygenation of blood and tissues,

and metabolism of lactic acid. Although you cannot

change your genetic profile, you can benefit from your

genetic advantages and maximise your potential.

YOU CAN OVERCOME THE PAIN

FROM INTENSE EXERCISE AND

PRESSURE UNDER COMPETITION.

YOU CAN BETTER AVOID INJURIES.

Since the diet of athletes is a significant

factor for their Performance, there will be

DNADiet POWER and DNADiet ENDURANCE

containing also genetic factors which

affect athletes’s power and endurance

performance nutritional needs.

YOUR DNASport PERFORMANCE

ANALYSES GENES FOR CERTAIN

MUTATIONS ASSOCIATED

WITH ATHLETIC PERFORMANCE,

ALL DOCUMENTED IN SCIENTIFIC

LITERATURE. ARE YOU BETTER SUITEDTO SPORTS REQUIRING ENDURANCE, STRENGTH OR SPEED?Choose a sports that suits you. Learn how you can

improve your sport performance, following you genetic advantages.

Identify your athletic strengths and weaknesses.

YOUR DNASport [iD]

GDF5

COL5a1

SPORT INJURIES

SPORT PERFORMANCE

ADRB2

AGT

ACE

BDRK2

MSTN

ACTN3

VEGF

PPARGα

TRAINING & RECOVERY

IL6R

IL6

CRP

SOD2

NOS

28 29[iD]DNA®

ultra-custom

ARE YOU GENETICALLY PREDISPOSED TO HAIR LOSS?Your DNA determines when you start showing hair loss, if this is androgenetic alopecia

or just stress, how quickly and at what rate your alopecia could worsen as becoming irreversible

baldness, which is unique to you.

Your DNAHair profile will detail your risk of irreversible androgenetic alopecia and the best

corrective professional treatment, so that you can take action straight away.

ARx

Xq12

EDA2Rx

Xq12

20p1120

20p11

GPX3

3p21.31

OXIDATIVE STRESS HAIR LOSS

GENETIC PREDISPOSITIONAndro-Genetic

Alopecia

YOUR DNAHair [iD]

[iD]DNA® test, genetic report and treatments are not intended, and should not be used, to diagnose or treat any diseases or medical conditions.

[iD]DNA® is a exclusive swiss patented pending concept, covered by international trademarks and intellectual property rights protection worldwide.

[iD]DNA® and all its brands, trademarks, products and materials belong exclusively to Suisse Life Science SA and are to be used for informational purposes only.

idna.works

Science of [DNA] f(x)™ = [(1+1+1+1) x (174+2) x 3] = 1.002.276 INDIVIDUAL TREATMENT COMBINATIONS

30 [iD]DNA®

ultra-custom

© 2014 all rights reserved - touts droits rèservès Suisse Life Science S.A. - SWITZERLAND

www.suisselifescience.com

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TREATMENT IN THE WORLD

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