IIT Bombay R & D at IIT Bombay · Mobile microscopy platform to detect sickle cell disease • Early stage dignosis for faster management • Easy, quick and affordable Technologies

R &

D a

t IIT

Bom

bay

• Academic units: 27; Research centres: 21• Faculty: ~620• Students: ~10,000 (2941 PhD)• Postdoctoral fellows: ~130• Degrees awarded in 2016: 2515• R&D funding for (April-Dec 2016): ₨285 Cr.• Publications in 2016: 1785 (Journals: 1274; Conference: 511)

• Indian patents filed (2016): 81 • Technology transfers/deployment so far: ~150• Total companies incubated: 99

Knowhow

Knowledge generation

R &

D O

utpu

ts

Solution to society

Technology

development

Expe

rt ad

vise a

nd

cons

ultan

cy

Leadership and

policies

Outreach

Generous revenue sharing

Industry friendly

Simple processes

Inventor friendly policies

In-house incubator

Cost for protection of

IITB IP

Facilitating Innovation

Period 1.1.1997 to 1.1.2017• Indian patent applications: 659• Foreign patent applications: 123 • PCT applications: 102• Patents granted (Indian + Foreign): 124 + 54 - Others under process

Pate

nts

IITB wins the National Intellectual Property Award 2015

Indigenously developed ECR-1000 ethernet switch router

IIT B

omba

y at

a G

lanc

eDean (R&D)IIT Bombay Powai, Mumbai 400076 +91-22-2576 [email protected]

Industrial Research and Consultancy Centre (IRCC) Nodal unit for coordinating and managing activities related to R&D

Fuel additives

Soil Biotechnology based sewage treatment plant at Mumbai Corporation

IIT Bombay

Roadmap to rural connectivity

• Imported lifesaving haemodialysers are very expensive and unaffordable

• Economically viable Hollow Fibre Membrane (HFM) technology for haemodialysers developed

• Greater biocompatibility and superior separation performance

Status:Preparation of hollow fibre cartridges, Animal and clinical trials under initiation; patent pending

Tube tube heat exchanger• Low cost double vented wall heat exchanger• Compact and cost effective

Multi-utility heat pump• Integrated, low cost compact, easy to operate• On-demand supply of hot / cold water

Diabetic contacting device• Air humidifier• Indirect evaporative cooler• Evaporative condenser/de-superheater/sub-cooler

• Fresh air dehumidifier• Hybrid air conditioning system

Diabatic contacting device

Multi-utility heat pump

Exhaust heat recovery unit Tube tube heat exchanger

Ener

gy C

onse

rvat

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Syst

ems

Hollo

w F

ibre

Mem

bran

e Te

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for K

idne

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alys

is

Prof. J. BellareDept. of Chemical

[email protected]

Prof. M. V. Rane Dept. of Mechanical [email protected]

Users• Manufacturers of haemodialysers

• Patients, nephrologists, industry, dialysis centres and hospitals

Features &

Advantages

High performance compared to commercial

haemodialysers

Superior bio-compatibility for renal patients

Low cost indigenous technology

Shorter dialysis time

Status: Available for licensing

Heating / cooling - Air / water / process fluid

R

IIT Bombay

IIT Bombay

Dark

Col

ored

Coo

l Roo

f Co

atin

gs T

echn

olog

y

• Soil moisture / temperature sensor, ambient humidity / temperature sensor,

• Sensors and systems for agricultural and civil engineering applications

• Effective use of water in agriculture, sustainability

• Make it profitable to farmers

Lo

w C

ost S

oil M

onito

ring

Syst

em F

or Ir

rigat

ion

Cont

rol

Status:Patents pending, ‘SoilSenS’ under process of incubation

Prof. M. S. Baghini Dept. of Electrical [email protected]

• Designed to reflect Near Infra Red (NIR) waves of solar radiation, on roof

• Lowers roof / room temperature by 10-140C• More effective than conventional insulation coating• Available in wide range of colors• Highly affordable• Excellent surface finish • Good waterproofing / weatherability• Easy application

Status: Available for licensing

Prof.A.S.Khanna Dept. of Metallurgical

Engineering and Materials Science

[email protected]

Acknowledgments: Meity, IISc, Semi-Conductor Laboratory, Dept. of Space, Govt. of India

Field deployment: Hyderabad Field deployment: Nasik

Field deployment: Delhi

R• Agricultural and industrial buildings• Temporary / permanent roofing materials• Tiles, shingles, marble slabs, concrete walls etc.

IIT Bombay

IIT Bombay

• Uses combined additive and subtractive Hybrid Layered Manufacturing (HLM) process

• Near-net shape manufactured in layers by depositing metal through MIG welding

• Faster and cheaper than laser and electron beam based deposition systems

• Can be adopted as a retro-fitment to existing CNCs

• Complex features possibleRapi

d To

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g an

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actu

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of M

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ompo

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• Planar deposition in 3-axis HLM for small undercuts and after blinding them

• Non-planar and variable axis deposition

• Multiple welding torches based deposition

Prof. K. P. KarunakaranDept. of Mechanical [email protected]

SüChekA cost-effective glucometer

• High accuracy: compliant with ISO 15197 • Uses low cost colour changing reagent strips• Mobile connectivity: effective analysis • Small, portable and lightweight (<100 gms)

uChekA mobile based low-cost, efficient and error proof urine analysis system• ≥ 95% accuracy; registered with USFDA• Affordable, simple to use, results in <5 seconds• < 500 gms; bedside testing possible• Integrated data organiser

SüCh

ek &

uCh

ek:

Diag

nost

ic De

vices

Prof. R. SrivastavaDept. of Biosciences &

[email protected]

Status:Produced and marketed by Biosense Technologies Pvt Ltd.

Hermle 5-axis CNC machining centre Near-net shapeCAD model finished dies

Tilted position(Overhang in-line with)

Normal position (Greater overhang) Case study

R

IIT Bombay

IIT Bombay

Pulse Tube Cryocoolers• Vibration and maintenance free • Can attain & maintain temp. < 80K• Single Stage PTC–U-type: 50-60K in 30-40 mins

• Two-Stage PTC–U-type: 20-25K attainable in 1 hr

Cryo

cool

ers

Sust

aina

ble

Land

fills

for

Smal

l Tow

nshi

ps

• Economical method for disposing municipal solid waste (MSW)

• Decentralized sustainable engineered bioreactor landfills (SEBLF) developed

• Accelerates decomposition / energy recovery and value added products

• Aerobic and anaerobic field models developed• Moisture content and temperature of MSW monitored / controlled

• Recirculation of leachate to accelerate decomposition• Periodic analysis of recirculated leachate characteristics

• Good reduction in C, H and N content in the bioreactors

SEBLF-AETypical variation in the moisture and temperature with time in the SEBLF

• Accelerated decomposition

• Energy recovery and value added products

SEBLF-AN installation of the FDR probe and thermocouple in the SEBLF-AN

Status:• Customisation possible • Ready for commercialisation

Single stage PTC experimental setu lInline; U-type: coaxial single-stage PTCs

Prof. M. AtreyDept. of Mechanical [email protected]

Prof.D.N.Singh Dept. of Civil Engineering

[email protected]

• Imaging equipment for night vision and heat-seeking missile guidance

• Cooling electronic devices and sensors

R

• Cooling of infrared sensors• Gas cooling / liquefaction

• Cryo-preservation• Laboratory equipment

Mixed Refrigerant Joule-Thomson Cryocooler

• low cost, efficient, reliable• 70–120K in <1 hour

R

IIT Bombay

IIT Bombay

R

Low

Cos

t Vei

n Tr

acer

• Convenient, light weight and affordable• Ergonomic, user friendly• LED light deflected by deoxygenated blood giving a clear silhouette of veins

Beagle-Z: to empower homeland security• Amplifying Fluorescent Polymer based handheld device• Proprietary embedded software running on microcontroller• RS-232 Serial Interface based communication• 7.5V, 2200mAh (Li-ion battery pack), 12V DC adaptor • Real-time detection• No radioactive source

Beag

le-Z

: Han

dhel

d Ex

plos

ive D

etec

tor

StatusTechnology transferred to Bigtec Pvt. Ltd.Prof.Anil Kumar

Dept. of Chemistry [email protected]

Prof. B. K. Chakravarthy Industrial Design Centre

[email protected]

Final prototype rendering

Study of form for gripping and ease of use

Pilot production sample

Status:Usability testing underway

• In busy and frugally run blood camps• Blood banks• Small and medium sized hospitals

R

IIT Bombay

IIT Bombay

• People Screening: Check points, Post blast sites• Vehicle Screening• Building screening: terrorists hot-spots, places of importance, crowded establishments

R

• Low cost, accurate and reliable domestic water meter

• For both rural and urban water supply schemes

• Low maintenance• No moving parts• Long battery life >5yrs• Alarms: misuse-tamper; reverse flow• Tailor made billing software• Highly accurate & reliable• Automatic wireless data collection on centralized serverSm

art U

ltras

onic

Wat

er M

eter

Prof. P. S. V. Nataraj Systems and Control [email protected]

Nove

l Swi

tche

d Re

luct

ance

Mot

or D

rive

for C

eilin

g Fa

n

• Singly excited motor• No permanent magnets• No coils on rotor• High reliability• Lower PE requirement• DC grid compatibility• Smart control

Prof. B. G. Fernandes Dept. of Electrical

[email protected]

Status• Field tested on IIT Bombay campus

• Ready and available for licensing

• For individual houses, high rise residential complexes, and commercial complexes

R

The market: 40 million/year • Current market share of high efficiency fans: 0.2%

• 350 million existing Induction motor fans

• High efficiency• Low cost• High payback• Up to 50% less power consumption• Potential savings: - 19,162 GWhr/yr - 8,750 MW peak

IIT Bombay

IIT Bombay

Board Games• Short games for entertainment• Encourage spatial intelligence and mental imagery

• Allows foresight and planning capabilities

Prod

uct D

esig

ns

Industrial Design Centrewww.idc.iitb.ac.in

Diab

etic

Foot

Sc

reen

ing

Devic

e

• Handy and compact design • Sensitive sensor to measure force accurately• Reduces cost burden• 5 wire connection• 5 Volts DC, 100Hz• Operating force: 0-1.5lb• Operating temperature: 0 to 700C

• Transforming any stethoscope into a “Digital Stethoscope”

• Volume control• Recording and playback option• Bluetooth connectivity• Detachable chest-piece• Provision for simultaneous auscultation

Dry sanitation system

ByClip:Bicycle parking rack

Prof.B.Ravi Department of

Mechanical [email protected]

[email protected]

Prof. B. Ravi Dept. of Mechanical [email protected]

Digi

Stet

h - D

igita

l st

etho

scop

e

• Patent filed• Licensed to C Tech Pvt. Ltd.

p

User centric novel design for effective arrangement of large no. of bicycles

t

IIT Bombay

IIT Bombay

IIT Bombay

Status:• Primary trials being conducted

• Prototype to product underway

Status:• Patent filed • Available for licensing

Status: Design registrations filed; Manufactured and marketed by the Funskool (India) Ltd.; `Zero Sum’ in Japanese market by Gakken

Mobile microscopy platform to detect sickle cell disease• Early stage dignosis for faster management • Easy, quick and affordable

Technologies to monitor ECG, EMG, EOG and SpO2, for implantable and wearable applications

Compact prototypes with customised Application Specific Integrated Circuits (ASICs)

Status: Patents pending; prototypes successfully tested in home and hospital environment

Tech

nolo

gies

for W

eara

ble

Heal

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Tech

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for A

fford

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He

alth

care

Prof. Debjani Paul Dept. of Biosciences and

[email protected]

Prof. Maryam S Baghini Dept. of Electrical [email protected]

Debjani(Paul(Micro0luidics(and(Biological(Physics(Lab,(Department(of(Biosciences(and(Bioengineering(

Email:'[email protected];'Web:'http://www.bio.iitb.ac.in/~dpaul/(1.(Micro0luidics(and(mobile(microscopy(platform(to(detect(sickle(cell(disease(

•  Con0irmed,(pointAofAcare(diagnosis(in(<(1h(

•  Indian(patent(application(201621026630(on(shape(detection(of(red(blood(cells(

Rapid&smear&microscopy&

•  Indian&patent&application&165/Mum/2015.&•  One8step&lysis&and&ampli;ication&of&M.#tuberculosis#(;iled&for&Indian&patent)&

•  Shetty&et&al.,&RSC#Advances,&6,&56205&(2016).&

Towards&micro1luidic&point6of6care&diagnostic&devices&O.&Sharma,&P.&Shetty,&C.&D'Costa,&D.&Ghosh,&M.&Singh,&S.&Singh,&A.&Tripathi,&N.&Mehendale&and&D.&Paul&Micro1luidics&and&Biological&Physics&lab,&Dept.&of&Biosciences&and&Bioengineering&&

Mobile&microscope&&

Statistics& HbS&vs.&HbA& Disease&vs.&trait&Sensitivity& 100%& 81%&Speci1icity& 100%& 96%&

•  Con;irmed&detection&•  Rapid&(<&1&hour)&•  Inexpensive&

A&paper1luidics6based&rapid&molecular&diagnostic&test&for&tuberculosis&

9.6&million&new&TB&cases&in&2014&

Africa&(28%)&

India&(23%)&

Indonesia&(10%)&

China&(10%)&

Others&(29%)&

GeneXpert&(Cepheid&Inc.)&

•  98%&speci;icity&and&80%&sensitivity&

•  Expensive&(~USD&17,000&after&subsidies)&

•  50%&8&70%&sensitivity.&&•  Sensitivity&decreases&for&fewer&than&5,000810,000&cells/ml.&

Paper;luidic&chip&

PCR&tube&&

OR&

Our&strategy:&Detecting&TB&by&isothermal&ampli1ication&on&paper&

Some&existing&technologies&for&TB&detection&

Intellectual&property&

Worldwide&incidences&of&TB&

A&shape6based&classi1ication&system&to&diagnose&sickle&cell&disease&at&the&point&of&care&

Worldwide&prevalence& Mobile&microscope&and&micro1luidics& Existing&technologies&

•  Indian&patent&application&4743/Mum/2015&

•  A&shape8based&classi;ication&system&to&diagnose&sickle&cell&disease&at&the&point&of&care&(;iled&for&patent).&


Funding&sources:&Wadhwani&Research&Centre&for&Bioengineering,&IIT&Bombay,&Bill&and&Melinda&Gates&Foundation;&Innovative&Young&Biotechnologist&Award&(Department&of&Biotechnology);&&

Isothermal&ampli;ication&

Fluorescence&

Gel&electrophoresis&

Source:+WHO+tuberculosis+report+(2015)+ •  Novel&one8step&protocol&combining&lysis&and&isothermal&ampli;ication&

•  Rapid&•  Suitable&for&point8of8care&

use&

Image&processing&

2.(Paper0luidic(platform(for(rapid(ampli0ication(of(tuberculosis(DNA(

•  Indian(patent(applications(165/Mum/2015(and(201621026481(

3.(HomeAbased(monitoring(of(oral(health( 4.(CloggingAfree(micro0luidic(device(for(cell(sorting(based(on(physical(properties(

•  PaperAbased(test(for(susceptibility(to(dental(caries(

•  Indian(patent(applications(1652/Mum/2014(and(1653/Mum/2014(Paperfluidic platform for rapid amplification of tuberculosis

DNA• One-step disinfection, lysis and amplification technique • Less manual intervention









Mobile&microscope&&





Africa&(28%)&

India&(23%)&

Indonesia&(10%)&

China&(10%)&

Others&(29%)&





Paper;luidic&chip&

PCR&tube&&

OR&












Fluorescence&




use&

Image&processing&





•  Indian(patent(applications(1652/Mum/2014(and(1653/Mum/2014(

Home-based monitoring of oral health• Fully printable paper-fluidic device• Cheap, disposable, easy to manufacture• Suitable for oral health monitoring and screening









Mobile&microscope&&





Africa&(28%)&

India&(23%)&

Indonesia&(10%)&

China&(10%)&

Others&(29%)&





Paper;luidic&chip&

PCR&tube&&

OR&












Fluorescence&




use&

Image&processing&





•  Indian(patent(applications(1652/Mum/2014(and(1653/Mum/2014(

Life-Sense : Real-time monitoring of ECG/PPG data on any Android mobile or desktop

Oxi-Sense: Non-invasive, fast,

accurate measurement of blood oxygen

saturation level and heart rate using

custom designed ASIC

Heart-Sense: Light weight portable device for continuous

monitoring of ECG and heart rate

Bio-WiTel: Custom set of transmitter and receiver ASICs

pu

u

p

IIT Bombay

IIT Bombay

Tata

Cen

tre fo

r Te

chno

logy

and

Des

ign

• Low cost portable system for detecting E. coli bacteria• Based on evanescent wave absorbance • Able to perform real time, label-free detection of ~250 E. coli cells in 0.25 ml sample

• Modest detection limit obtained as trade-off between sensitivity and simplified design

µSEN

S - F

iber

Opt

ic Ba

sed

Dete

ctio

n Sy

stem

Prof. Soumyo Mukherji Dept. of Biosciences and Bioengineering [email protected]

Tata Centre for Technology and

[email protected]

• UV light emitting diode, spectrometer

• U-bent fiber optic probe of 200μm core diameter, 0.75mm bend radius

• Effective probe length of 1cm

Instrumentation:• UV source: T9H28C (280nm)• UV detector: SIC01M (280 – 400nm)• Multimode optical fiber, core diameter of 200 – 400µm

• Microcontroller: MSP430F1611• Display unit: 20 × 4 line Alphanumeric LCD display

The centre aims to develop solutions to challenges faced by resource constrained communities using an end to end innovation approach

Gynae Cam: Cervical cancer screening device

Removing drudgery in jaggery-making

Clay-based water purifier

Gasifier based cook-stoves for garden waste

Low-power transceivers for wireless communication

Functional nanohybrids to treat cancer

Biliscope: Jaundice detection in neonates

Bone graft for bone reconstruction

Low cost, rugged solar PV microinverter

IIT Bombay

IIT Bombay

Documents

IIT Bombay R & D at IIT Bombay · Mobile microscopy platform to detect sickle cell disease • Early stage dignosis for faster management • Easy, quick and affordable Technologies