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1
Immunology First Midterm Exam
1. If the patient is exposed to an antigen for the second time, then all the
following are true EXCEPT :
<c+> B cell receptor can’t bind to a free antigen.
2. Which of the following stages of B cell development receptor editing
takes place :
<c+> immature B cell.
3. Which of the following mainly supports an immune response against
intracellular viruses :
<c+> good expression of class I MHC genes.
4. All of the following are properties of adaptive cell mediated immune
response EXCEPT :
<c+> mediated by activated macrophages.
5. All of the following are proposed to lead to tolerance EXCEPT :
<c+> the use of an adjuvant.
6. Which of the following cells can induce very strong apoptotic signals in
their targets ?
<c+> T cytotoxic cell.
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7. All of the following molecules are involved in lymphocytes homing and
trafficking EXCEPT :
<c+> CD80.
8. All of the following are true of B1 cells EXCEPT :
<c+< they produce high specific antibodies compared to conventional cells.
9. IgE antibodies can be expressed on the surface of B cells only when :
<c+> epsilon chain gene is selected following isotype switching of the heavy
chain gene epsilon.
10. All of the following are true about IgG molecule treatment with
pepsin EXCEPT :
<c+> it can still bind J chain in IgA dimer.
11. All of the following are going to affect the diversity of antibody
EXCEPT :
<c+> constant light kappa chain.
12. Positive selection, what does it mean ?
<c+> the process by which developing T cells that express a specific alpha
beta T cell receptor able to interact appropriately with self MHC continue
differentiation.
13. Which of the following cells has receptors for the Fc part of the IgE
antibodies ?
<c+> mast cells.
14. All of the following are true concerning oral tolerance EXCEPT :
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<c+> performed by lymphocytes in the paracortical area of the lymph
nodes.
15. T cell development the double negative stage is most likely to be
seen in :
<c+> subcapsular area of the thymus gland.
16. All of the following can be present in B cell EXCEPT :
<c+> the zeta chain of the coreceptor molecule.
17. Which of the following binds initially to the Lck during T cell
signaling?
<c+> tail of the CD4.
18. Which of the following steps will not take place in the activation of
the phospholipase gamma C pathway when the drug tacrolimus is added?
<c+> no increase in influx of calcium inside the cell.
19. Which of the following cytokines play a major role in the activation
bone marrow in general to induce hematopoiesis ?
<c+> IL-3.
20. Which of the following organs is going to be affected in deficiency in
the autoimmune regulatory gene ?
<c+> suprarenalglands.
21. Which of the following lymphokines is going to be affected the most
when there is a mutation affecting the transcription factor Foxp 3 ?
<c+> IL-10.
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22. Your classmate recently had his MHC analyzed and he found out that
he is completely homozygous at class I and class II. How many different
allelic forms in locus A you expect to find in the surface of macrophage?
<c+> 1.
23. All of the following are true of NK cells EXCEPT :
<c+> they undergo positive selection in the cortical area of the thymus.
24. All of the following genes can be involved in switching in process of
isotype switching EXCEPT :
<c+> Delta.
25. The effect of homozygous mutation introduced into the germline
that eliminated expression of invariant chain will show :
<c+> lack of MHC class II expression.
26. Alternative splicing in IgM and IgD is done at the level of :
<c+> RNA splicing.
27. What is the main feature of malignant cells used in the monoclonal
antibody production by somatic hybridization ?
<c+> they die in specific selection medium.
28. Which of the following is true concerning lymph nodes ?
<c+> large number of macrophages are present in the medulla.
29. Which of the following Ig is the most important in lactating mother
breast feeding her baby ?
<c+> IgA.
5
30. Allotypic differences between antibody molecules refer to :
<c+> differences between antibodies of the same class or subclass between
different individuals.
31. Which of the following structures D genes play a major role in their
development ?
<c+> variable region of the beta chain of the TCR.
32. All of the following are true of receptor editing EXCEPT :
<c+> B cell variable light and variable heavy chains are involved is this
process.
33. Which fraction of the serum protein electrophoresis contains most of
the immunoglobulin ?
<c+> gamma wave.
34. All of the following molecules contain ITAMS EXCEPT :
<c+> the TCR beta chain.
35. All are true about T helper II cells EXCEPT :
<c+> involved in intracellular immunity against intracellular bacteria.
36. All of the following are true o superantigen EXCEPT :
<c+> induce immune response specific to the superantigen.
37. Which of the following can be detected using the technique of next
lymphocyte culture :
<c+> Allelic form in locus DR.
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38. All of the following combination can be made by a single antibody
secreting cell EXCEPT :
<c+> Kappa an Lambda.
39. Which of the following statements regarding epitopes is false ?
<c+> epitiope is never part of antibody.
40. Which of the following coreceptor marker is specific for B cells only ?
<c+> Ig alpha.
41. When we detect syphilis serologically by dark field microscopy we
use which libratory technique ?
<c+> immunofluoresce.
42. The fact that only 1 of 4 is active in any single B lymphocyte the test
will have either field combination of an unused this is due to mainly :
<c+> Allelic exclusion.
43. All of the following types of diversity generation are used in
antibodies EXCEPT :
<c+> Allelic exclusion.
44. All of the following lead to SCIDD EXCEPT :
<c+> defect in the Syk protein synthesis.
45. All of the following are true of gamma delta T cell types EXCEPT :
<c+> They are mainly present in the GI tract.
46. Which disease has a very high relative risk with HLA-27 :
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<c+> Ankylosing sponidlitis.
47. Which of the following is not a specific antigen recognizing molecule?
<c+> complement.
48. All of the following domains are parts of the Fab region of an
antibody EXCEPT :
<c+> the constant heavy 2.
49. When we count CD4 cells in a patient with AIDS we use which
laboratory technique ?
<c+> flow cytometry.
50. In which of the following TdT is used to add up more diversity of
specificity of antibodies :
<c+> junctional diversity.