IMMUNOTOXICOLOGY Specialty Section · Collinge ([email protected]) and Jamie ([email protected])], Education Chair Florence Burlenson ([email protected]) or Emanuela Corsini

IMMUNOTOXICOLOGY

Specialty Section

1 Immunotoxicology Specialty Section

2019-2020

Executive Committee

President

Emanuela Corsini

Vice President

Mark Collinge

Vice President-Elect

Florence G. Burleson

Secretary/Treasurer

Randle M. Gallucci

Past President

Jamie DeWitt

Senior Councilor

Jennifer Wheeler

Junior Councilor

Allison Ehrlich

Postdoc Representative

Alessandro Venosa

Student Representative

Alexa Murray

The Immunotoxicology Specialty Section

(ITSS) Newsletter is published twice a year

(Summer and Winter). If you would like to

share an item of interest with members of

the ITSS, please send it to the

Communications Committee Chair. All

comments and suggestions are welcome.

Alessandro Venosa

[email protected]

Alexa Murray

[email protected]

Allison Ehrlich

[email protected]

Summer Edition

Incoming President’s Message 1

Outgoing President’s Message 4

ITSS Program at SOT 5

ITSS Committees 6

Student Post-doctoral Report 7

2019 Award Winners 8

Member Spotlight 12

Endowment Fund Update 14

Recent Immunotoxicology Publications 15

Immunotoxicology Membership Achievements and Awards 17

Save the date 18

Job Postings (from SOT Job Bank) 19

February 2019

Incoming President’s Message

Greetings fellow Immunotoxicologists! Time flies, already two years

passed since I was elected, and I am now the incoming ITSS

president for the 2019-2020 term, what an honor to serve. It seems

not long ago that I joined SOT and ITSS…it was 1992 so technically a

long time ago, since then I think I missed only 2-3 SOT annual

meetings. For those members that are less familiar with me, my

career in Immunotoxicology began under the mentorship of Drs. Mike

I. Luster and Gary Rosenthal at the NIEHS, where I spent two and half

wonderful years. Since then, I have been working in the Laboratory of

Toxicology, directed by Prof. Corrado Galli, in charge of the

Immunotoxicology and Immunopharmacology Unit, at the School of

Pharmacy of the University of Milan, Italy. As full professor in

toxicology, I am active in training undergraduate and graduate

students and in research. Currently, my research focuses on the

refinement of alternative in vitro tests for immunotoxicity, and on the

understanding at the molecular level the mechanism of action of

immunotoxic/immunomodulatory compounds. I am active in several

scientific and professional organizations, and I serve on several

editorial boards of toxicology journals. Regarding my experiences in

scientific societies, from 1999-2005 I served as Treasure for the Italian

Association for in vitro Toxicology; from 2009-2013 I was Member of

EUROTOX Education Sub Committee, from 2005-2011 I was the

Chair of the Immunotoxicology and Chemical Specialty Section at

EUROTOX; from 2010-2016 I was member of the IUTOX Executive

Committee; from 2017-2019 member of the Award Committee at SOT;

and from 2013 I am member of the EUROTOX Executive Committee.

President’s Message (Continued)

I think this is enough about me. I must sincerely thank the last year’s ITSS Executive Committee

and the leadership provided by Dr. Jamie Dewitt, outgoing ITSS President, and I am sure you all

remember her energy and organizational skills at the last SOT in Baltimore. A real great group to

work with, and Jamie, you know, you are not getting away that easy, we still have monthly

teleconferences and continue in our purposes.

I would also like to welcome the new members to the Executive Committee, Dr. Florence

Burleson (Vice President-Elect), Burleson Research Tehnologies, Inc.; Dr. Randy Gallucci

(Secretary/Treasurer), University of Oklahoma Health Sciences Center; and Dr. Allison Ehrlich

(Junior Councilor), Oregon State University.

The ITSS Executive Committee also sends thanks to the subcommittees and their volunteers,

including Education, Membership, Awards, and Program. Thanks for all the hard work!

The 2019-2020 year will be busy for the ITSS Executive Committee as usual. We want to build off

the successes from last year and continue to improve the visibility of our specialty section and its

impact within toxicology and within the SOT annual meeting.

In line with previous years, I would like to take an opportunity to highlight the main goals for ITSS

for the coming year.

Goal 1: Identify and/or create educational opportunities for ITSS membership. We will

continue to advertise all training opportunities for graduate students and postdocs as well as

continuing education, and mentoring event at SOT annual meeting. The ITSS Education

Committee will work hard to identify educational opportunities and translate them to the

membership. All ITSS members are welcome to contribute: if you find a course or webinar or other

training tool, please bring this to the attention of the ITSS Executive Committee [email to Mark

Collinge ([email protected]) and Jamie ([email protected])], Education Chair Florence

Burlenson ([email protected]) or Emanuela Corsini ([email protected]) so that we

can help spread the word.

February 2019 2 Immunotoxicology Specialty Section

Goal 2: Foster International Scientific Exchange and

Collaboration. The ITSS has a long- standing relationship

with the Japanese Society of Immunotoxicology (JSIT). This

partnership was established in 2005 to provide a vehicle for

exchange of science and education on an international level.

This program has been extremely successful and has led to

cutting-edge scientific presentations given by ITSS members

at the JSIT meeting and reciprocal presentation of cutting-

edge science by JSIT members

at the SOT meeting. We are proud to continue this relationship and to expand the

communication between ITSS and JSIT. This year Jamie Bonner from NC State University will

be our representative at the annual meeting of the JSIT. Reciprocal publications in respective

newsletters is now an ongoing strategy to share ideas and accomplishments throughout the

year. Building on the success of the ITSS-JSIT collaboration, the ITSS Executive Committee is

also expanding outreach to the Immunotoxicology and Chemical Allergy Specialty Section at

EUROTOX. A joint symposium has been proposed for SOT2020. Fingers crossed!

President’s Message (Continued)

Goal 4: Continue to involve the ITSS Past Presidents in the ITSS activities. The Science Advisory

subcommittee has been formalized under ITSS and will be tasked with reaching out to the Past

Presidents and engaging them in scientific discussions that will benefit the membership. One

excellent opportunity that comes to mind is a discussion about future hot topics and creating seeds

for program proposals. This will help foster the science that ITSS wants to represent at future

meeting. Past Presidents, be ready, keep an open mind, and let’s see where this can take us in our

pursuit of everything that is Immunotoxicology.

On behalf of the 2019-2020 ITSS Executive Committee, we look forward to working for the

membership for the coming year. We welcome and encourage any and all interactions with ITSS

members with the goal of making the specialty section inviting, productive, and visible.

We look forward to seeing you next year in Anaheim, CA!

As usual, if you have any questions, concerns, or suggestions, please feel free to reach out

to any member of the ITSS Executive Committee.

Best regards,

Emanuela Corsini, PhD

Universita’ degli Studi di Milano

President ITSS

February 2019 3 Immunotoxicology Specialty Section

Goal 3: Solidification of Endowment Fund. I will speak for the entire ITSS membership in

thanking Drs. Prakesh and Mitzi Nagarkatti for their gracious donation that established a new ITSS

Endowment Fund, now known as the “Mitzi and Prakash Nagarkatti Research Excellence in

Immunotoxicology Award Fund”. This fund is designed to encourage and recognize graduate

students and postdoctoral scholars for their excellence in research involving mechanisms of

immunomodulation in health and disease. The fund will provide travel awards for graduate

students and postdoctoral scholars to attend the SOT meeting providing them the opportunity to

present their research, gain valuable feedback from peers, learn cutting-edge science, and build a

network. In order to make this endowment fund permanent and receive matching funds from SOT

(this year will be the last year for SOT matching as SOT decided to shut down the program), ITSS

needs to raise only $1,150 to bring the fund to $25,000 and make it permanent.

SOT has made it easy for members to contribute to

the endowment. Please follow this link

(https://www.toxicology.org/endowment/ifc/fundC

ontributors.asp) and scroll to find the “Mitzi and

Prakash Nagarkatti Research Excellence in

Immunotoxicology Award Fund”.

Any and all contributions are welcome and greatly appreciated. We are almost there to

make it permanent!!!

Outgoing President’s Message

July 2019 4 Immunotoxicology Specialty Section

When we are in the midst of activities for a year, it seems like the year will never end. When that year is over, we stare in amazement at the calendar and how rapidly all of those days flew by. However, it’s usually a good idea to take stock of whether or not those activities resulted in meaningful outcomes. What did the ITSS accomplish in 2018-2019? It was my honor to serve as the ITSS President during this year and to work with a truly outstanding Executive Committee. The work of an organization is almost never done by one individual, but by a team of individuals concentrating on shared vision, goals, and objectives. As I look back through the Executive Committee teleconference agendas and subsequent minutes from the year, I see ambitious plans for ITSS that were carried out with enthusiasm and dedication. We updated mission statements for several of the committees, went live with a redesigned ITSS web site (largely due to the efforts of the 2017-2018 Executive Committee), supported international collaboration with the JSIT, and watched your donations help to grow the two endowment funds that support student and postdoc travel to the annual SOT meeting. We also endorsed nearly a dozen proposals for the annual SOT meeting, selected recipients for ITSS awards, and organized the reception that you all enjoyed at the annual SOT meeting. Of course, other tasks involved with the functioning of the specialty section were undertaken over the year as well. I encourage you all to stay active within the ITSS. Join a committee if you haven’t already done so (the awards committee will need members as the nominations start to roll in at the end of the year/early part of 2020). Run for an Executive Committee position! Elections take place at the end of the calendar year but it’s never too early to let our current president (Dr. Emanuela Corsini) know that you want your name on the slate for a particular position. At the very least, attend sessions endorsed by the ITSS, visit posters that focus on immunotoxicology, and enjoy catching up with colleagues at the annual meeting reception. The ITSS is a great specialty section because of the comradery of its members! I look forward to serving the 2019-2020 Executive Committee as Past-President and know that the current officers will guide the ITSS through this next year with typical enthusiasm and dedication! Dr. Jamie DeWitt President, ITSS 2018-2019 Past-President, ITSS 2019-2020

Enjoying a recent trip to Switzerland to talk about per- and polyfluoroalkyl substances (PFAS)!

ITSS Programs at SOT 2019

There are so many options to consider in addition to the above mentioned CE courses, symposia

and workshops. The latter is now available in two flavors: the canonical 165 minute session and

90 minute sessions. The latter would also allow for a 30-minute break before the following

session that can be used to promote interactions between attendees or follow ups with speakers.

Programming Committee is here to help!

Here is some useful advice to get you started: •The session presentations should be designed to provide a cohesive thread throughout the session.

•The session should address a topical issue of broad general relevance, rather than a narrow topic of

high interest to fewer scientists.

•The session presenters should reflect a diversity of opinions/backgrounds to reflect perspectives

from industry/regulators/academics.

•CE courses have a better chance of acceptance, as do roundtables – think about these formats as

a possibility.

Don't miss the opportunity to contribute to a program by submitting your scientific

proposal! Thank you in advance for your continuous support and contribution. We look

forward to receiving your proposal!


Program Committee

Chair 2019-2020: Mark Collinge

Chair 2020-2021: Florence Burleson

It’s never too early to start planning

Dear ITSS members,

Let me start by thanking you all for your attendance to the ITSS-sponsored 2019

symposia!

In Baltimore, ITSS sponsored two continuing education courses on “Mechanistic

Understanding and Quantitative Risk Assessment in Immunotoxicology.” and ‘Microbiome and

Environmental Toxicants: From Study Design and Analysis to Regulatory Guidance’, two

symposia on “Immune-Epithelial Cell Crosstalk in Lung Toxicology and Disease” and “The

Current Application, Limitations, and Recent Advances in Humanized Mouse Models for

Evaluations of Immune Function and Preclinical Immunotoxicology Studies “, and one

workshop on “Understanding the Impact on the Immune System of Occupationally Relevant

Exposures to Multiwalled Carbon Nanotubes”.

The submission period for SOT

2020 is past but it is never too early

to think about 2021!! Your active participation within the Specialty

Section is vital for the section itself.

We know that the process of putting together a proposal may feel daunting, especially for

trainees. However, the ITSS program committee is here to help you submit the most competitive

proposal possible.

July 2019

ITSS Committees

6 Immunotoxicology Specialty Section July 2019

Education Committee

Mark Collinge Cody Smith

Jiajun (Brian) Zhou Travis Gulledge

Programming and Scientific Advisory

Committee

Vic Johnson Berran Yucesoy

Amira Mohammed Peer Karmaus

Ankit Shah Joanna Matheson

Awards Committee

Jennifer Wheeler Tina Satterwhite Wendy Freebern

Amira Mohammed Berran Yucesoy

Jean Sathish Wurood Neamah David McMillan

Yining Jin Joanna Matheson Anthony Franchini Michael McCabe

Michael Whitekas

Communications and Membership Committee

Allison Ehrlich

Alessandro Venosa Alexa Murray

Hasan Alghetaa Jiajun (brian) Zhou

Volunteers are always welcome:

SOT membership is required. Must be willing to become a member of the ITSS and to

commit to service. Please see the Committees page of the ITSS website for details.

Dear graduate students and postdocs,

It is an exciting summer ahead of us! We’re already in July! We watched fireworks and

celebrated, spent some time with family, and soon enough (too soon if you ask me) we’ll

start worrying about the next academic year.

Here are some quick updates from the past SOT meeting in Baltimore:

1. First and foremost, Baltimore's weather was much more clement this year, and that

already felt like a win! It was a great meeting and we are happy to say that the ITSS

sponsored symposia/workshop/CE courses were a great success!

2. We hosted the 5th ITSS mentoring event. We had 15 trainees attending and a remarkable

attendance from mentors (10) from academia, industry and government. We received

positive feedback about the format, speed dating-like rotation of the trainees. For next

year, based on your comments, we will reduce the timed component and provide some

time at the end of the event to have informal conversation with mentors you want to follow

up with. We keep striving to improve and make each event the best it can be!

3. We are working on CE courses and additional symposia for next year’s SOT meeting. We

will provide more information as we get closer to the meeting. If you missed out on the

opportunity to submit your proposals for 2020, do not worry! It is never too early to start

planning for 2021. If you need help getting started, the ITSS programming committee is

here to help! We’ll work together to tailor your ideas to their full potential.

4. Lastly, ITSS will be looking for a new postdoctoral representative, with the position

starting May 2020. If you are interested please contact me ([email protected])

or Alexa ([email protected]) ! In addition, we also encourage the ITSS trainee

members to participate in any other ITSS committee. This is a great way to get involved in

leadership activities with other ITSS members and to enhance your professional network.

There are 4 different committees within ITSS: Awards, Program, Education and

Communication/Membership.

Keep up with the great science and see you in 2020!

Student & Postdoctoral Report


Alessandro Venosa, Pharm.D., Ph.D. and Alexa Murray, Ph.D. Candidate

July 2019

mailto:[email protected]


Outstanding Senior Investigator Award

The Vos Award for Lifetime Career Achievement in Immunotoxicology is presented to an

individual in recognition of career achievements in advancing the field of immunotoxicology

through service, leadership, and scientific contributions.

The Outstanding Senior Investigator Award is presented to an individual whose work has made

significant contributions to the field of Immunotoxicology. This award is for scientists in

academia, industry, or those who have had an impact on regulatory issues, and has

distinguished themselves as leaders in their chosen area of immunotoxicology.

2019 ITSS Award Winners:

Vos Award for Lifetime Career Achievement in Immunotoxicology

Dr. Frank Gerberick Adjunct Appointment in Innovations in Food & Chemical Safety (IFCS) Programme at A*STAR

Dr. Raymond H.H. Pieters

Immunotoxicology, Institute for Risk

Assessment Sciences, Utrecht

University, The Netherlands


Outstanding Young Investigator Award

The Outstanding Young Investigator Award is presented to an individual whose work has made

significant contributions to the field of Immunotoxicology. This award is for scientists in

academia, industry, or those who have had an impact on regulatory issues, having 10 years or

less of experience since obtaining their highest degree.

Dr. Jonathan Shannahan

Assistant Professor of Health Sciences and

Toxicology

Purdue University

Mitzi and Prakash Nagarkatti

Research Excellence in

Immunotoxicology Student

Award

Brian Zhou

Michigan State University

Mitzi and Prakash Nagarkatti

Research Excellence in

Immunotoxicology Award

Dr. Hui Wang




Best Paper of the Year 2018

Heedoo Lee1, Duo Zhang1, Debra

Laskin2, and Yang Jin1 1Division of Pulmonary and Critical Care Medicine,

Boston University 2Department of Pharmacology and Toxicology,

Rutgers University

Functional evidence of pulmonary

extracellular vesicles in infectious and

noninfectious lung inflammation



Health and Environmental Sciences Institute (HESI)

Immunotoxicology Young Investigator Travel Award

Dr. Yining Jing


Best Presentation by a Student Award

Robert Freeborn



Best Presentation by a Postdoctoral Trainee Award

Dr. Lance K. Blevins


Identification and characterization of a

sensitive immunologic target of TCDD:

CD5+ innate-like B cells


Member Spotlight

Cheryl Rockwell, Ph.D.,

Associate Professor, Pharmacology & Toxicology


• When did you begin your career in immunotoxicology?

In 2000, when I started my dissertation research in

Dr. Norb Kaminski’s lab.

• When did you start participating in the ITSS?

I became a member of ITSS as a graduate student. At first,

I simply attended the ITSS reception, but gradually started

becoming active in committee work.

• What motivated you to be a part of ITSS?

Really there are a lot of benefits. It is a great way to network and meet people as a

trainee. I also felt like I wanted to give back to ITSS because it is very supportive of

trainees. Also, I enjoy working on ITSS committees 😊

• What was your most rewarding experience involving ITSS?

There have been many, but probably initiating the first couple of

Mentoring/Networking events with Ashwini Phadnis was the most rewarding. I have

also enjoyed serving on the Awards committee and as Councilor to ITSS.

• How did you make the transition to independence? Any advice for the

trainees out there?

It takes some patience and a plan. You have to be deliberate in how you will

eventually make that leap. You also need to be able to adjust your plan as you go

along. Hard work is critical. If I were to identify a crucial mistake that I made early

on, it would be that I did not initially get enough feedback from multiple perspectives

on those first couple of fellowship applications.

• What element of your training had the largest impact on your personal and

scientific growth?

It is hard to identify a single element. However, in retrospect, I think learned more

and grew as a scientist during those times when I felt like I was failing rather than

when everything was going well. The times when nothing was working in the lab

forced me to improvise and grow new troubleshooting muscles. Even receiving

crushing rejections of grants and manuscripts pushed my development forward at

times I think.


Member Spotlight (Continued)

• What experiences best prepared you for your job?

There have been so many. Dr. Norb Kaminski taught me the fundamentals of

becoming an effective researcher and grant writer. I gained a lot of independence

and confidence during my first postdoc in Dr. Nilo Qureshi’s lab—I also learned a lot

more about grant-writing from Dr. David Morrison at that time. My current scientific

interests were ignited during my second post-doc in Dr. Curt Klaassen’s lab. All of

these experiences have shaped me into the scientist I am today.

• How does the future look in the immunotoxicology field?

The future is unquestionably bright from the perspective that there are more jobs and

opportunities in our area than ever before. There are new challenges for us to

tackle—I believe these challenges will keep us all very busy for many, many years to

come.

• What would you do (or currently do) to improve industry-academia

interactions?

I agree that we need to work together more. I am not sure how to accomplish this on

the industry side, however I have lots of ideas for the academic side. Many of our

academic institutions have a fair amount of bureaucracy—this can impact the speed

of research. We need to figure out a system that accomplishes the goals and needs

of the universities without sacrificing large amounts of time and resources on the side

of the scientists who wish to collaborate. I think the slow speed of universities is a

deterrent to collaboration.

• What has been the largest benefit, for you, of being an active participant in

an SOT SS like the ITSS?

SOT is a unique scientific society in that it solicits and relies heavily on volunteer

activities from its membership. I love this aspect of our society. It provides so many

opportunities to be engaged. SOT members have the opportunity to shape the

scientific programs and many other aspects of the society. SOT is also unique in that

its membership is split among academia, industry and regulatory institutions—this is

a strength. I think SOT could serve as a model for other scientific societies in these

ways.

• What is one fun fact about yourself that you would like to share with others?

Hmmm—that is a toughie. With a 6-year-old and a 2-year-old at home, I have

become somewhat no-nonsense these days. However, my 6-year-old and I have

recently become avid geocachers, which is a fairly addictive activity for people who

like exploring the outdoors.


Endowment Fund Update

We wanted to take this opportunity to thank everyone who has contributed to the

Mitzi and Prakash Nagarkatti Research Excellence in Immunotoxicology

Award Fund. This fund was established to encourage graduate students and

postdoctoral scholars to pursue cutting-edge mechanistic research on

immunomodulation seen in health and disease and share that widely with the

research community.

The current amount of the endowment is $48,850 and we need to raise

$1,150 before January 2020 to make it permanent.

Keep in mind that SOT donation matching started July 1st 2019!!!

We thank you in advance for your generosity and look forward to making the

Nagarkatti Endowment a permanent part of the Immunotoxicology Specialty

Section!

Randle M. Gallucci

Secretary/Treasurer


Use the online giving system or download the Donation form to make a

gift to the Mitzi and Prakash Nagarkatti Research Excellence in

Immunotoxicology Award Fund

July 2019

https://www.aim-hq.com/netFORUMSOT/eWeb/DynamicPage.aspx?WebCode=LoginRequired&expires=yes&Site=SOT






http://www.toxicology.org/endowment/docs/Endowment_Donor_form.pdf









Recent Publications Compiled by Alessandro Venosa and Alexa Murray. Anytime you have a new fully-

published or electronically available article to report, please send the citation to

Alessandro at [email protected].

Beamer CA, Kreitinger JM, Cole SL, Shepherd DM. Targeted deletion of the aryl hydrocarbon receptor

in dendritic cells prevents thymic atrophy in response to dioxin. Arch Toxicol. [Epub ahead of print]

Bechara R, Maillere B, Joseph D, Weaver RJ, Pallardy M. Identification and characterization of a naïve

CD8+ T-cell repertoire for benzylpenicillin. Clin Exp Allergy. 2019 Jan 18. doi: 10.1111/cea.13338. [Epub

ahead of print]

Buoso E, Ronfani M, Galasso M, Ventura D, Corsini E, Racchi M. Cortisol-induced SRSF3 expression

promotes GR splicing, RACK1 expression and breast cancer cells migration. Pharmacol Res. 2019

May;143:17-26. doi: 10.1016/j.phrs.2019.03.008. Epub 2019 Mar 9. PubMed PMID: 30862604.

Calhoun KN, Luckett-Chastain LR, Frempah B, Gallucci RM. Associations Between Immune Phenotype

and Inflammation in Murine Models of Irritant Contact Dermatitis. Toxicol Sci. 2019 Mar 1;168(1):179-

189. doi: 10.1093/toxsci/kfy289. PubMed PMID: 30517752.

Franchini, Anthony, Myers Jason, Jin Guang-Bi, Shepherd David, and Lawrence Paige. Genome-Wide

Transcriptional Analysis Reveals Novel AhR Targets That Regulate Dendritic Cell Function during

Influenza A Virus Infection. ImmunoHorizons June 1, 2019, 3 (6) 219-235; DOI:

https://doi.org/10.4049/immunohorizons.1900004

Frempah B, Luckett-Chastain LR, Gallucci RM. IL6Rα function in myeloid cells modulates the

inflammatory response during Irritant Contact Dermatitis. Exp Dermatol. 2019 Jun 5;. doi:

10.1111/exd.13984. [Epub ahead of print] PubMed PMID: 31165501.

Frempah B, Luckett-Chastain LR, Calhoun KN, Gallucci RM. Keratinocyte-specific deletion of the IL-

6RΑ exacerbates the inflammatory response during irritant contact dermatitis. Toxicology. 2019 May

31;423:123-131. doi: 10.1016/j.tox.2019.05.015. [Epub ahead of print] PubMed PMID: 31158415.

Holaskova, Ida, Meenal Elliott, Kathleen Brundage, Ewa Lukomska, Rosana Schafer and John B

Barnett. 2019. Long-term immunotoxic effects of oral prenatal and neonatal atrazine exposure. Toxicol

Sciences. (ahead of print) doi: 10.1093/toxsci/kfz005

Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM,

Mulugeta S, Deterding RR, and Beers MF. A SFTPC BRICHOS Mutant Links Epithelial ER Stress and

Spontaneous Lung Fibrosis. Journal of Clinical Investigation Insight. 2019;4(6):e126125.

Kavasi RM, Berdiaki A, Spyridaki I, Papoutsidakis A, Corsini E, Tsatsakis A, Tzanakakis G, Dragana N.

Contact allergen (PPD and DNCB)-induced keratinocyte sensitization is partly mediated through a low

molecular weight hyaluronan LMWHA)/TLR4/NF-κB signaling axis. Toxicol Appl Pharmacol. 2019 Jun

18:114632. doi: 10.1016/j.taap.2019.114632. [Epub ahead of print] PubMed PMID: 31226360.

Ishihara Y, Haarmann-Stemmann T, Kado NY, Vogel CFA. Interleukin 33 expression induced by aryl

hydrocarbon receptor in macrophages. Toxicol Sci. 2019 May 15.pii: kfz114. doi: 10.1093/toxsci/kfz114.

July 2019




Recent Publications (Continued)

Ishihara Y, Kado SY, Hoeper C, Harel S, Vogel CFA. Role of NF-kB RelB in Aryl Hydrocarbon Receptor-

Mediated Ligand Specific Effects. Int J Mol Sci. 2019 May 30;20(11). pii: E2652. doi:

10.3390/ijms20112652

Impinen A, Longnecker MP, Nygaard UC, London SJ, Ferguson KK, Haug LS, Granum B. Maternal

levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related

outcomes and infections in the Norwegian Mother and Child (MoBa) cohort. Environ Int. 2019 Jan

23;124:462-472.

Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains

and of the allergenicity of products containing rice bran. Food Chem. 2019 Mar 15;276:761-767.

Tsuji M, Koriyama C, Ishihara Y, Vogel CFA, Kawamoto T. Association between bisphenol A diglycidyl

ether-specific IgG in serum and food sensitization in young children. Eur J Med Res. 2018 Dec

26;23(1):61.

Venosa A, Katzen J, Tomer Y, Kopp M, Jamil S, Russo SJ, Mulugeta S, and Beers MF. Epithelial

Expression of an Interstitial Lung Disease Associated Mutation in Surfactant Protein-C Modulates

Recruitment and Activation of Key Myeloid Cell Populations in Mice. Journal of Immunology, 2019. 202

(9) 2760-2771

Vogel CFA, Ishihara Y, Campbell CE, Kado SY, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-

Stemmann T, Tuscano JM. A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation

and Tumor Growth. Cancers (Basel). 2019 Apr 27;11(5).

Yang Z, Zhao Y, Li Q, Shao Y, Yu X, Cong W, Jia X, Qu W, Cheng L, Xue P, Zhou Z, He M, Zhang Y.

Developmental exposure to mercury chloride impairs social behavior in male offspring dependent on

genetic background and maternal autoimmune environment. Toxicol Appl Pharmacol. 2019 May

1;370:1-13. doi: 10.1016/j.taap.2019.03.006. Epub 2019 Mar 9.


Achievements and Awards

Danuta Herzyk, PhD (past ITSS President)

Sr Scientific Director at Merck Pharmaceuticals SOT Scientific Program Committee


Cheryl Rockwell, PhD

Associate Professor

Department of Pharmacology & Toxicology


2019 Early Career Award ASPET Toxicology Division

Alessandro Venosa, PharmD, PhD

Postdoctoral Researcher

University of Pennsylvania School of Medicine

2019 Usha Awards APS, Respiratory Section

A symposium to recognize the career of

Dr. Nancy Kerkvliet

member in the College of Veterinary Medicine at Oregon State University in 1976 and

joined the Department of Environmental and Molecular Toxicology in 1995.

During this time she has mentored many graduate students and postdoctoral fellows that

have gone on to successful scientific careers. For her excellence in mentoring she was

presented with the Women in Toxicology Mentoring Award in 2014. Dr. Kerkvliet has

served the scientific community as President of the Society of Toxicology

Immunotoxicology Specialty Section, the President of the Pacific Northwest Association of

Toxicology (PANWAT) and received the PANWAT Achievement Award in 2011. Dr.

Kerkvliet’s scientific career evolved in concert with the evolving field of immunotoxicology.

During most of this time, she has been focused on trying to understand the mechanisms

of aryl hydrocarbon receptor (AHR)-mediated immunomodulation. Until recently, most of

her work was focused on 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), the most potent

AHR ligand and notorious as a toxic environmental contaminant. Her laboratory was the

first to describe the potent suppression of T cell dependent immune responses by TCDD

and investigated the cellular basis for the suppression, describing AHR-driven changes in

T cells and dendritic cells. Dr. Kerkvliet was also first to identify the ability of AHR

activation to induce regulatory T cells. AHR regulation of T cell differentiation is now the

subject of research in laboratories around the world. This event organized by Kerkvliet’s

former trainees and colleagues represents a celebration and demonstration of their

appreciation for her efforts over the past half-century. Please join us in beautiful Corvallis!

Here is a link to the meeting web site:

https://emt.oregonstate.edu/kerkvlietsymposium/kerkvlietsymposium.

You can register even if you cannot attend – There is a portal for everyone to write a

personal message – sharing memoires, stories, and pictures for Nancy that we will collate

in a bound book.

Oregon State University, Corvallis, OR

Friday September 13, 2019 | 8:30-4:00 PM

This event organized by Dr. Kerkvliet’s former trainees and colleagues represents a celebration and demonstration of their

appreciation for her collective efforts over the past half-century.

Save the date


We are pleased to announce a Career Recognition

Symposium and Celebration honoring the career of Professor

Nancy Kerkvliet to take place on the Oregon State University

Campus on September 13th, 2019. Dr. Kerkvliet received her

BS degree (1970) from University of Wisconsin-Eau Claire and

her MS (1973) and PhD (1976) in Interdisciplinary Biological

Sciences at Oregon State University. She became a faculty

https://emt.oregonstate.edu/kerkvlietsymposium/kerkvlietsymposium

Job Postings (from SOT Job Bank)


Organization Location Job Title

AbbVie North Chicago, IL

United States Occupational Toxicologist

AbbVie North Chicago, IL

United States Senior Scientist II/III, Toxicology

ANGUS Chemical Company Buffalo Grove, IL

United States North & South America Product Steward

Apple Cupertino, CA

United States

Senior Toxicologist / Senior Biocompatibility

Engineer

Arylessence Marietta, GA

United States Regulatory Affairs Manager

Bill & Melinda Gates Research

Institute

Cambridge, MA

United States Discovery Project Leader- Toxicology

BioMarin Pharmaceutical San Rafael , CA

United States

Scientist 2: PreClinical Pharmacology /

Toxicology, Pharmacological Sciences

California Environmental

Protection Agency

Sacramento, CA

United States Deputy Director of Scientific Programs

ChemoCentryx Mountain View, California

United States Director of Toxicology

Cornell University Ithaca, NY

United States

Postdoctoral Associate_Molecular and

Neuroendocrine Toxicology

Covance Madison, WI

United States

Associate Director/ Scientific Lead – PK

Modeling & Simulation

Covance Madison, WI

United States Pharmacokineticist Associate

CropLife America Washington, DC

United States Director, Science Policy

Dechra Portland , Maine

United States

Product Development Manager, Global Drug

Safety

Department of Pesticide

Regulation, California EPA

Sacramento, California

United States Epidemiologist/Biostatistician

Department of Pesticide

Regulation, California EPA

Sacramento, California

United States Dermal Toxicologist

Eastman Chemical Company Kingpsort, TN

United States

Lead, Toxicology and Regulatory Assesment

Services

Environmental Protection

Agency

Washington, DC

United States

Biologist/Toxicologist/Physical

Scientist/Chemist

EPA Washington, DC

United States Biologist/Toxicologist

EPA Washington, DC


EPA Washington, DC


FDA Silver Spring, MD

United States Post-doctoral Fellow

July 2019




Florida International University Miami, Florida

United States

Tenure-Track Assistant Professor -

Department of Environmental Health Sciences

Food & Drug Administration Silver Spring, Maryland

United States

Post-doctoral fellow position: Assess the

applicability of alternatives to animal testing for

detection of potential allergens in medical

devices

Fresenius Medical Care Waltham, MA

United States Senior Toxicologist

Genentech

South San Francisco,

California

United States

Study Operations Manager

Givaudan Singapore Senior Manager Regulatory Affairs & Product

Safety (Toxicology) in Singapore

Givaudan France Manager, Toxicology – Regulatory and

Product Safety (RAPS)

Gossamer Bio San Diego, CA

United States Senior Scientist, Toxicology

Institute for In Vitro Sciences Gaithersburg, Maryland

United States Toxicologist - I


United States

Post-doctoral Scientist – Respiratory

Toxicology & Immunology


United States Toxicologist II - Respiratory

International Flavors &

Fragrances

Union Beach, New Jersey

United States Food and Flavoring Toxicologist

Mary Kay Inc. Lewisville, TX

United States Senior Scientist Product Safety

Medpace Cincinnati, Ohio

United States

Nonclinical Drug Development Strategist -

Pharmacology, Pharmacokinetics, Toxicology

Michigan State University United States Postdoctoral Position in Immunotoxicology

Michigan State University United States Postdoctoral Position in Immunopharmacology

Michigan State University East Lansing, MI

United States Post-Doctoral Research Associate

National Institute for

Occupational Safety and Health

Cincinnati, OH

United States Toxicologist/Risk Assessor

National Institute of

Environmental Health Sciences

RTP, NC

United States

Editor-in-Chief, Environmental Health

Perspectives

Nestlé Lausanne,

Switzerland Senior Food Safety and Toxicology Scientist

NJ Dept. of Env. Protection Trenton, NJ

United States Research Scientist 2 - Toxicologist

Novartis Cambridge, MD

United States

Safety Assessment Expert, Preclinical Safety

(PCS)

July 2019




Novartis Pharma AG Cambridge, MA

United States

Senior Investigator, Cell and Gene Therapy

Expert

Pacific Northwest National

Laboratory

Richland, WA

United States Exposure Science in Genetics


Laboratory

Richland, WA

United States Data Science and Bioinformatics


Laboratory

Richland, WA

United States

Human Exposure, Toxicology and Precision

Medicine

Regeneron Tarrytown, New York

United States Staff Scientist, Toxicology - 15571BR

Reynolds American Winston-Salem, NC

United States Systems Biologist - Biomarker Research

Rimkus United States Principal Toxicologist

Rimkus Consulting Group Houston, Texas

United States Toxicologist

Roche Innovation Center

Shanghai

Shanghai,

China Group Head PS-iSafe RICS,

SciLucent Herndon, VA

United States

Senior/Principal Regulatory Toxicology

Consultant

Silent Spring Institute Newton, MA

United States

Bioinformatics and Data Science for Public

Health

Stockholm University Stockholm, Sverige

Sweden

Postdoctoral Fellow in Molecular in vitro

Toxicology

The University of Arizona Tucson, AZ

United States

Full/Associate Professor in Environmental

Health Sciences

Toxics Use Reduction Institute,

UMass Lowell

Lowell, MA

United States TURI Science/EHS Support Specialist

University at Albany Rensselaer, New York

United States Assistant/Associate Professor

University of Alabama at

Birmingham

Birmingham, AL

United States

Assistant or Associate Professor -

Environmental Health Sciences

University of Minnesota Saint Paul, Minnesota

United States

Pharmacology/Toxicology in Food Animal

Production Assistant or Associate Professor

University of Rochester Rochester, NY

United States

Postdoctoral Positions in Inhalation

Toxicology

US Food and Drug

Administration

Silver Spring, MD

United States Research Toxicologist, Risk Assessor

US Food and Drug

Administration

Silver Spring, Maryland

United States

Post-doctoral Fellow Nanotechnology Organ-

on-a-Chip

WestChina-Frontier

PharmaTech

Chengdu, Sichuan

China

Veterinarian; Market Manager; Study Director

of Pharmacokinetics; Pathologist; Study

Director

Xerox Corporation Webster, New York

United States Regulatory Toxicologist

July 2019

Documents

IMMUNOTOXICOLOGY Specialty Section · Collinge ([email protected]) and Jamie ([email protected])], Education Chair Florence Burlenson ([email protected]) or Emanuela Corsini