IN SEARCH OF AN IDEAL ANTICOAGULANT AGENTTej Shidhaye, Divya Joshi, The GTF Group

INTRODUCTION

1. GTF spreads awareness ofthrombosis in the community

2. There are so many drugs thatare available for the managementof thrombi

3. Objective of this research was tosee if we have reached our idealanticoagulant agent

THE CLOTTINGPROCESS

THE COAGULATIONCASCADE

POSSIBLECONSEQUENCES OF A

THROMBUS

HEPARIN: THE MASTER1. Heparin, the firstanticoagulant,discovered accidentallyin 1916 by Jay McLean,a second-year medicalstudent, Department ofPhysiology, JohnsHopkins Medical

HAVE WE REACHED ANIDEAL ANTICOAGULANT,

YET?

School, Baltimore, under thedirection of the eminent scientistWilliam Howell2. October 2016, HeparinCentennial was celebrated all overthe World and at Loyola University,in which a few of the GTFmembers had participated (TheLaddu's, Rohil Badkundri)

● Deep Vein Thrombosis(DVT)● Pulmonary Embolism (PE)● Heart Attack (myocardial

infarction)● Stroke● Kidney Failure● Problems during pregnancy

(miscarriage)

ANTICOAGULANTS1. Clotting is a good andprotective mechanism for thebody

2. Blood clots can produceharmful effects such as:

CONCLUSIONS

Jay McLean

DIRECT THROMBIN INHIBITORS(DTI)1. Hirudin2. Argatroban: A synthetic DTI3. Dabigatran (Pradaxa)DIRECT FACTOR XaINHIBITORS1. Rivaroxaban (Xarelto)2. Apixaban (Eliquis):3. Edoxaban (Savaysa)

TYPES OF ANTICOAGULANTS1. Oral tablets (Warfarin, Pradaxa)2. Injectables (Heparin, LowMolecular Weight Heparin)

HAVE WE REACHED THE TOPOF THE HIMALAYAS, YET?1. Our search for an idealanticoagulant agent is not yet over2. Our message: Keep on trying,until we succeed

* Novel (new) Oral Anticoagulants

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