0031-6997/79/2914-0617$02.00/OPHARMACOLOGICAL REVIEWS

Copyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics

Index

Pharmacological Reviews

Volume 30

1978

Vol. 30, No.4Printed in U.SA

Aaronson, P. See van Breemen et a!., 167

Absorption, drug. See Drug absorptionAcetaminophen

-induced hepatotoxicity by phenacetin in the mouse,

inhibition of (table), 466

metabolism, pathways of (fig.), 464

metabolites, and liver necrosis, relationship between

glutathione levels in liver and cobinding of

(table), 465

Acetylcholine

as local hormone, 117

cell-cell communication and, 117

determination of, 71

environmental messenger, 116formation of

by coupled synthesis, 74

from coenzyme A and choline, 74

growth and, 118

in erythrocytes, 96

in spermatozoa, 99

maturation, development, and, 118

other choline esters and, 68

permeability and, 117

placental, effect of drug abuse on intrauterine

growth, 113

roles of, in non-nervous tissues, 116

trophic factors and, 118

Acetyicholine noise, surface of an uninnervated my-

otube (fig.), 421

Acetylcholine power spectra, and synaptic currents,at neonatal and adult rat endplates (fig.),422

Acetylcholine receptor, 71

acetylcholinesterase and, accumulation at newlyformed nerve-muscle synapses, 411

brain extract-induced increase in, in cultured my-

otubes (fig.), 420clusters of, 412

on uninnervated myotubes, 413; (fig.), 415distribution of, on an innervated muscle fiber (fig.),

414modification of, 420

synapse formation in vitro, 412Acetylcholine sensitivity, mean channel open time as

function of (fig.), 421Acetylcholinesterase

accumulation of, 423acetylcholine receptors and, accumulation of, at

newly formed nerve-muscle synapses, 411

activities of, in sperm from various segments ofepididymis, 99

curare-treated myotubee stained for (fig.), 425

in erythrocytes, substances that inactivate and their

effects on properties of erythrocyte8 (table),96

in platelets, 96

in sperm fractions, 100

release from platelets, 97

Acetylcholinesterase stain and synaptic current decay,correlation between (fig.), 424

Acetyltransferase, choline. See Choline acetyltranafer-

ase

Adaptation and homeostasis, 352Adenine nucleotides, release from platelets, 97

Adenylate cyclase, hormonal modulation of, 405

Adipocytes, alpha-adrenoceptors and ion permeability

regulation, 235Adrenergic inhibition and excitation and cardiac mem-

brane currents, 42a-Adrenoceptors and cardiac currents, 44/3-Adrenoceptors and cardiac membrane current sys-

tems, 45Adrenocorticotrophin, estimates of in vivo half-lives

in the rat, dog, sheep, pig, and man (table),260

Age-dependent changesin drug distribution, 447

hepatic drug metabolism, 448

hepatic microsomal drug-metabolizing system, 452

in hepatobiliary function, 454

noninicrosomal hepatic drug metabolism, 453

renal clearance of drugs, 448Age-related changeS

in drug disposition, 445

intestinal drug absorption, 446

Amino acids of glycophorin A (fig.), 375Anaphylaxis with thromboxane A2, prostacyclin, and

prostaglandin endoperoxides, 317

Angiotensins I and II, vasoactive peptides, 253Anodonta cygnea cellensis, components of cholinergic

system in gills of, 79Antiarrhythmic drugs. See under Drugs

Antioxidants, antimutagenic effects of, 549

Antipyrine, genetic factors and variations in elimina-tion rates of (fig.), 559

Arachidonic acidmetabolic pathways of (fig.), 294

metabolism, 295

617

618 INDEX

Arrhythmias, cardiac. See Cardiac arrhythmias

Arrhythmogenesis

altered excitability and, 31

membrane factors in, 24

Ascorbic acid-induced sensitization of human fibroblasts to 4-

nitroquinoline 1-oxide (fig.), 495

mutagemc action and DNA-damaging capacity of

oxidation products of (table), 496

Ataxia telangiectasia, sister chromatid exchange for-

mation in, 526

Bacteria, components of cholinergic systems in, 75

Batzinger, Robert P. See Bueding et al., 547

Becker, Bernard. See Newbeme et al., 335

Bennett, Hugh P. J., and Cohn McMartin. Peptide

hormones and their analogues: Distribution,

clearance from the circulation, and inactiva-

tion in vivo, 247

Bioassay of acetylcholine, 71

Bishydroxycoumarin, genetic factors and variations inelimination rates of (fig.), 559

Blohm, Thomas R. Drug-induced lysosomal lipidosis:Biochemical interpretations, 593

Blood cells, cholinergic systems in, 93

Bloom’s syndrome, sister chromatid exchange forma-

tion in, 526

Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to

drugs, 429

Bousquet, William F. See Newberne et al., 335

Bradykinin, vasoactive peptide, 253

Bromobenzene metabolism, pathways of (fig.), 463

5-Bromo-2’-deoxyuridinemethodology for sister chromatid exchange, 501

staining protocols for detecting incorporation of,

into metaphase chromosomes (table), 502

techniques, sister chromatid differentiation (fig.),502

Bueding, Ernest, Robert P. Batzinger, Young-Nam

Cha, Paul Talalay, and Christopher J. Moli-neaux. Protection from mutagemc effects of

antischistosomal and other drugs, 547

Calcitonin, 266

arteriovenous differences in radioimmunoassayableconcentrations of, across organs in the dog

(table), 268

decay of blood peptide concentrations in vitro and

in vivo, 266

estimates of in viva half-lives in preparations in the

rat, dog, pig, and man (table), 267Calcium

role, in receptor regulation of membrane permeabil-ity, 209

sodium-, interactions. See Sodium-calcium interac-

tionsCalcium current, agents which modify, 50

Calcium transport and sequestering systems, interre-

lation of, with respect to control of cytoplas-mic ionic calcium (fig.), 201

Calliphora salivary gland, 226Cancer impact of compound, total (table), 353

Carcinogen action

complex patterns of, 496

modulating effect of noncarcinogenic chemical

agents on, 494

CarcinogensDNA and, interactions, 493-DNA interactions, modulating factors, 494

hepatic activation of (table), 483risk assessment and acceptable risk, 364

Carcinogenic/mutagenic impact, by chemicals (table),353

Carcinogenesis bioassays, maximum tolerated dose

(MTD), lessons learned from, 362

Cardiac arrhythmias

ionic mechanisms in heart muscle in relation togenesis and pharmacological control of, 5

reentry and depressed conduction, 29; (fig.), 30

Cardiac membrane currents

a-adrenoceptors and, 44f1-adrenoceptors and, 45adrenergic inhibition and excitation and, 42; (fig.),

44

Cardiac muscle, acetylcholine action on, 84

Cardiovascular disease, serum dopamine fl-hydroxyl-

888 activity in, 157Cell-cell communication and acetylcholine, 117

Cell membranehormone receptor interactions at, 393

organization of, development of a model, 394

Cell nucleus in toxicological investigations (workshop

summary), 342

Cell surface, implications for toxicology (workshopsummary), 336

Cha, Young-Nam. See Bueding et al., 547

Chediak-Higashi syndrome, 589

Chemical agents

noncarcinogenic

inhibitory action of, on DNA repair, 495

modulating effect of, on carcinogen action, 494

Chemical interference with mitochondrial function,

606

Chiorthion effect on metabolism of testosterone byliver microsomes (table), 460

Cholecystokinin, 265

Choline acetyltransferases, 70

activities of, in sperm from various segments of

epididymis, 99

biosynthesis of acethycholine, 73

in spermatozoa, 99in sperm fractions, 100

Cholinergic system

components of

in cultured cells and developing cell systems, 90in tissues with nervous and non-nervous compo-

nents, 83

in organisms and tissues without nerves, 75

INDEX

469

in tissues with remote involvement with nervoussystem, 80

in blood cells, 93in developing nerve structures, properties of first

and second phase (table), 92in non-nervous tissues, 65in placenta, 102

in plants, 115in spermatozoa, 98

Cholinesterase, 70

assay of, 73

in spermatozoa, 99

Chromatin fiber, 470

folding of, in metaphase chromosomes, evidence forradial loops, 470

organization of, in radial loop model (fig.), 474

Chromosomal assays, mammalian cell models, 542

Chromosome

-damaging metabolites, catalytic activity of Cu�

ions on thiol compounds in generating (ta-

ble), 496

metaphase

folding of chromatin fiber in, evidence for radialloops, 470

histone-depleted (fig.), 471

surface topology of, electron micrograph (fig.), 473swollen with EDTA, cross section of chromatid of

(fig.), 472

Cilia, acetyicholine role in diary movement, 81

Circadian rhythm, serum dopamine /3-hydroxylase,

150

Clastogens, sister chromatid exchange induction by,

505

Cocaine, relationship between membrane “clamp” po-tential and rise of action potential (fig.), 38

Codeine and morphine, plasma concentrations afteroral aspirin-codeine phosphate combination

(fig.), 462

Copper, catalytic activity of, on thiol compounds ingenerating DNA- and chromosome-damag-ing metabolites (table), 496

Core battery

selection criteria, 544short-term tests (table), 545

Cornea

acetyicholine as sensory mediator, 86

acetyicholine in regulation of water and ion traits-port, 87

Cotten, Marion deV., tribute to, 3Coumarin anticoagulant drugs, pedigree of family in-

dicating incidence of resistance to (fig.), 558

C-peptide, 272Cyclophosphamide, sister chromatid exchanges in

mouse liver cells by (fig.), 522

Cysteine

effect on covalent binding of acetaminophen to

mouse liver protein (table), 465effect on mutagemc action and DNA-damaging ca-

pacity of MNNG (table), 495Cytochrome P-450

619

catalytic activity of (table), 461physical properties of (table), 461

Cytoplasm, membrane systems of, implications for

toxicology (workshop summary), 339

DBH. See Dopamine $-hydroxylase

Deoxyribonucleic acid

-carcinogen interactions, modulating factors of, 494

damage, assays for, 541

damage, repair, and synthesis, relationship of sisterchromatid exchange to, 524

-damaging metabolites, catalytic activity of Cu��ions on thiol compounds in generating (ta-

ble), 496

effectiveness of covalent binding of various standard

substances to (table), 611elution during 5-bromo-2’-deoxyuridine dye-Giemsa

procedure (fig.), 503

fragmentation and repair assays, applications of (ta-ble), 498

fragmentation and repair of mammalian cells, mdi-cater for complex interactions between car-

cinogens and modulating factors, 493

organization levels of, in eucaryotic chromosomes,

repair

inhibitory action of noncarcinogemc chemical

agents on, 495

modulating effect of hyperthermia on, 497; (fig.),497

mechanisms, 493systems responding to alkylation (table), 353

sister chromatid interchange, evidence for, at DNA

level, 528; (fig.), 529

synthesis, unscheduled, 543

Diabetes, serum dopamine 16-hydroxylase activity in,159

Diener, Robert M. See Newberne et al., 335Diethyl maleate, effect on covalent binding of acet-

aminophen to mouse liver protein (table), 465Diphenylhydantoin action on cardiac membrane, 40

Dopamine $-hydroxylasebiochemical characteristics, 134

adrenal, 134

serum, 135

circadian rhythm effects, 150

enzymatic activity, assay of, 136release of, from an adrenergic varicosity (fig.), 143

serum, 133

activity of, in man and experimental animals (ta-ble), 140

assay procedures for, 136; (fig.), 137, 139

drug and hormone effects on activity of, 150

effects of

growth and development on, 146inheritance on, 147; (fig.), 148

stress on, 151immunoassay of, 141in cardiovascular disease, 157in endocrine disease, 158

Dopamine $-hydroxylase-continued

in familial dysautonomia, 157

in human disease, 154

in hypertension, 154

in manic depression, 158

in neuroblastoma, 158

in neurological disease, 157

in renal disease, 156

in schizophrenia, 158

in torsion dystonia, 157normal values, 140

regulation of, 145

source and fate of, 143Doxorubicin, ventricular tissue of rat treated with

injections of (fig.) 608Droperidol, cardiac electrophysiological properties of,

38

Drug absorption, intestinal, age-related changes in,

446

Drug abuse, interference with placental acetylcholine,effect on intrauterine growth, 113

Drug and steroid hydroxylation, requirements for (ta-

ble), 460

Drug distribution, age-dependent changes in, 447

Drug dispositionage-related changes in, 445

in experimental animals, variables affecting (table),

560

Drug-induced changes in phospholipid composition of

tissues (table), 599

Drug-induced lysosomal lipidosia, biochemical inter-

pretations, 593Drug metabolism. See under Metabolism

Drug-metabolizing enzyme system, hepatic micro-somal, age-dependent changes in, 452

Drug-phospholipid complex formation, 596

Drug response

gene-environment interactions, role of, as determi-

nants of drug response, 560

individual factor in, 555

antiarrhythmic

action mechanisms, 33

chemical structures (fig.), 35

classification of (table), 34

antischistosomal and other, protection from muta-

genie effects of, 547

commonly used, pharmacogenetics field expandedto include, 558

coumarin anticoagulant, pedigree of family mdicat-

ing incidence of resistance to (fig.), 558

effect on

ciliary movement of Mytilus edulis (table), 78serum dopamine fl-hydroxylase activity, 150

Hodgkin-Huxley theory, application to heart musclein relation to action of, 51

liver response to

model for assessment of, 430; (fig.), 431, 432, 433morphometric analysis in assessment of, 429

mutagemc activation of, by enteric microorganisms,

548

620 INDEX

production of abnormal response in pharmacoge-

netic conditions (table), 556

renal clearance of, age-dependent changes, 448toxicology of, workshop on, 335

Electrophysiology, myocardial, 5Endocrine disease, serum dopa.mine f3-hydroxylase ac-

tivity in, 159Endoperoxide analogues, structure of (fig.), 303

Endoperoxides, metabolism of, 319

Endorphins, opiate receptor agonists, 251

Enkephalins, opiate receptor agonists, 251

Enteric microorganisms, mutagemc activation of drugs

by, 548Environmental messenger, acetylcholine as, 116

Environment

mutagens and antiniutagens in, 359

mutagens from, source (table), 361Enzymatic catalytic site, distinction from ligand roe-

ognition site, 405

Enzyme, effect of infusion of, on glycogen concentra-

tion and recovery of infused enzyme in liverand muscle in glycogen storage disease Ha

(table), 578Enzyme deficiency diseases, relationship to lysosomal

lipidosis, 593Enzyme system, hepatic microsomal drug-metaboliz-

ing, age-dependent changes in, 452

Enzyme treatment, in five lysosomal disorders, 565Enzymes, inhibition of, in the biosynthetic pathway,

295

Epinephrine, effect of infusion of on glycogen concen-

tration in muscle and liver in glycogen storagedisease II (table), 577

Erythrocytes

acetylcholine in, 96acetylcholinesterase activity in, 93choline acetyltransferase in, 96musearinic receptors in, 96

Estrogen-receptor complexes, 479; (fig.), 480

RNA synthesis and, 485Estrogen-receptor interaction in target cells, 479

Eukaryotic chromosomes, DNA organization levels in,469

Eukaryotic microorganisms, point mutation assays,

540

Exocrine glands

calcium and stimulus-permeability coupling mech-

anisms, 214ion movements, role in, 214

mammalian, receptor control ofpermeability in, 225Exocrine pancreas. See under Pancreas

Familial dysautonomia, serum dopamine $-hydroxyl-

ase activity in, 157

Fanconi’s anemia, sister chromatid exchange forma-tion in, 526

Fatty acidsunstable derivatives of, 315

in platelets, 316Fibroblasts, acetylcholine action in, 90Fischbach, Gerald D., Eric Frank, Thomas M. Jessell,

INDEX

Lee L. Rubin, and Stephen M. Schuetze.

Accumulation of acetylcholine receptors and

acetylcholinesterase at newly formed nerve-

muscle synapses, 411

Food, mutagens in (table), 361

Food coloring, conversion of, by microflora (fig.), 360

Frank, Eric. See Fischbach et al., 411

Frog esophagus, acetylcholine and ciliary movement

in, 81, 82Frog skin, cholinesterases in, 81

Gap junctionshigh resistance, 383

information passed through, 389

in mouse liver (fig.), 384, 385electron micrograph (fig.), 386isolated, high-resistance (fig.), 387

low resistance, 388Gap junction dynamics and intercellular commurnca-

tion, 383

Gas chromatography, acetylcholine, 71Gastrin, 263

estimates of in vivo half-lives in the cat, dog, andman (table), 264

Gastrointestinal epithelia, calcium and stimulus-permeability coupling, 234

Gastrointestinal hormones, 263

Gastrointestinal tract, prostacyclin in, 317Gene conversion, mitotic, assays for mitotic recombi-

nation and, 541

Gene-environment interactions, role, as determinants

of drug response, 560

Gene mutation assays

mammalian cell models, 542

point or, bacterial, 540

Genes directly affecting drug disposition, intraspecies

differences in frequency of, 555

Gestation period, placental acetyicholine and trans-

port across placenta as function of, 112, 113

Glucagon, 271

Glucose 6-phosphatase, relative specific activity of,with endoplasmic reticulum (fig.), 434

a-Glucosidase activity in mouse liver after injection of

perfiuorinated particles (fig.), 582

Glutathione levels in liver, relationship with covalent

binding of acetaminophen metabolites andliver necrosis (table), 465

Glutathione depression and hepatic molecular binding,

related to exposure to vinyl chloride (fig.),357

Glycogeneffect of

enzyme infusion on concentration and recoveryof, infused enzyme in liver and muscle of agirl with glycogen storage disease Ha (table),

578

epinephrine infusion on concentration of, in mus-cle and liver in glycogen storage disease II

(table), 577Glycogen degradation, cytoplasmic phosphorylase

pathway of, activated by epinephrine infusion

621

(fig.), 568

Glycogenesis type H, prototype of lysosomal disease,

566

Glycogen storage disease

classification of (table), 567II

treatment, 575

haamniotic fluid cell of an 18-week-old fetus with

(fig.), 583

effect of enzyme infusion on glycogen concentra-

tion and recovery of infused enzyme in liver

and muscle of a girl with (table), 578liver biopsy specimen (fig.), 576

after enzyme infusion (fig.), 579

after epinephrine infusion (fig.), 577

after 3 weeks of enzyme infusion (fig.), 578

before infusion of enzymes (fig.), 568, 569

liver specimen of 18-week-old fetus (fig.), 571

muscle biopsy specimen (fig.), 570

skin fibroblasts of, that have ingested gold parti-

des (fig.), 580

hlbheart autopsy specimen (fig.), 573, 574

muscle biopsy specimen (fig.), 572muscle biopsy specimen in 11-year-old boy with

no clinical signs of the disease (fig.), 575

Glycophorin A

amino acids of (fig.), 375

lipid layer of intact red cell membrane, 376

multimeric forms, 377

phosphorylated molecules of, 378

Glycophorins, 374

Glycoprotein hormones, 278

anterior pituitary, 276

Golberg, Leon. Toxicology: Has a new era dawned?

351

Goodenough, Daniel A. Gap junction dynamics and

intercellular communication, 383

Granuloma pouch assay, 613

Gray, Jack E. See Newberne et al., 335Growth

acetylcholine and, 118

development and, effects on serum dopamine ,8-hy-droxylase, 146

intrauterine, retardation of, relationship to placental

acetylcholine and drugs of abuse, 113Growth control, receptor regulation and, 400

Growth hormone, 276

release inhibiting hormone or somatostatin, 258

Haemostasis, prostacyclin, and thromboxane A1-thrombosis, 313

Halothane metabolism, oxidative and reductive path-ways of, schematic representation (fig.), 358

Hauswirth, Otto, and Bramah N. Singh. Ionic mech-anisms in heart muscle in relation to thegenesis and the pharmacological control of

cardiac arrhythmias, 5Heart. See aLso entries under Cardiac, Myocardial

Heart muscle

622 INDEX

Immunochemical approaches to receptor studies, 487Inflammation, thromboxane A2, prostacyclin, and

Heart muscle-continued

Hodgkin-Huxley theory application to, in relationto drug action, 51

ionic mechanisms in, in relation to genesis and phar-macological control of cardiac arrhythmiaa,

5

Hemopoietic stem cell, component of cholinergic sys-tem in, 92

Hepatic activation of carcinogens (table), 463

Hepatic drug metabolism. See under Metabolism

Hepatic microsomal drug-metabolizing enzyme sys-tem, age-dependent changes in, 452

Hepatic molecular binding and glutathione depression,

related to exposure to vinyl chloride (fig.),

357Hepatobiliary function, age-dependent changes in, 454Hepatocytes

hypothetical, containing a single spherical nucleus,

changes occurring within (fig.), 435

stereological sorting of subpopulations of (fig.), 441

Hepatotoxicity, acetaminophen-induced, inhibition by

phenacetin in the mouse (table), 466Hexachiorophen and two stereoisomers, chemical

structures showing neurotoxicity (fig.), 607Hodgkin-Huxley concept, mechanisms of excitation,

10; (fig.), 11, 12, 14, 15, 17Hodgkin-Huxley model. modification of, 17; (fig.), 18,

19Hodgkin-Huxley theory, application to heart muscle

in relation to drug action, 51Hollenberg, Morley D. Hormone receptor interactions

at the cell membrane, 393

Homeostasisadaptation and, 352; (fig.), 354

vascular, prostacyclin release and role in, 310

Hormone

adenylate cyclase modulation by, 405

bound, intracellular localization of, 479effects on serum dopamine �8-hydroxy1ase activity,

150

hypothalamic, 256

local, acetylcholine as, 117

neurohypophyseal

analogues of, 255oxytocin and vasopressin, 254

pancreas, 271

parathyroid, 269

circulating forms of, 270

half-life in blood in vitro and in vivo, 269role of tissues in clearance and conversion of, 270

peptide

analogues and, distribution, clearance from cu-

culation, and inactivation in viva, 247anterior pituitary, 259assay, characterization and identification of, 249

bioassay of, 249

biological experimental methods, 250

chromatography, 249

comparison of metabolism of, 279concentrations in blood, role of tissues in decay

of, 264

identification of, 249

isotopically labelled, 249levels

blood, decay of, in vitro and in vivo, 255

role of tissues in decay of, 255

low molecular weight, primary structures of (fig.),

252

mechanisms of clearance and distribution, 280

metabolism. See under Metabolism

pyrolysis products isolated from (fig.), 361radioimmunoassay of, 249vasoactive, 253

protein, of anterior pituitary, 276

receptor modulation by, 400

receptor regulation and tachyphylaxis, 401

steroid, interaction of, with the nucleus, 477

Hormone acceptors versus receptors, 398

Hormone action

ligand internalization and, 402

membrane fluidity and mobile receptor paradigm of,395

mobile receptor model of (fig.), 394

predictions based on mathematical analysis of,

395receptor aggregation and, 396

receptor cooperativity and, 404

Hormone binding in target tissues, 478; (fig.), 478Hormone receptors

acceptors and, the problem of nonspecific binding,397

interactions at cell membrane, 393

regulation, 398

versus acceptors, 398

Hot spots, nerve-induced, 418; (fig.), 416Hottendorf, F. H. See Newberne et al., 335

Hug, George. Pre- and postnatal pathology, enzyme

treatment, and unresolved issues in five ly-sosomal disorders, 565

Human chromosome fragility diseases, sister chroma-

tid exchange formation in, 526Human respiratory epithelium, acetylcholine and cull-

sty activity in, 82Hurler’s disease, 583

cerebral cortex specimen of 19-week-old fetus with(fig.), 588

liver specimen of 19-week-old fetus with (fig.), 587

skin fibroblasts of, that pinocytosed colloidal gold

(fig.), 586

Hycanthone, radioactivity in sperm ejaculated after

injection of (table), 6135-Hydroxytryptamine, release from platelets, 97

Hypertension, serum dopamine fl-hydroxylase activityin, 154

Hyperthermia, modulating effect of, on DNA repair,497; (fig.), 497

Hypothalamic hormones, 256

INDEX 623

prostaglandin endoperoxides in, 317Inheritance, effects of, on serum dopamine $-hydrox-

ylase, 147Insulin, 272

estimates of in vivo half-lives of, in pig, baboon, and

man (table), 273Intercellular communication and gap junction dynam-

ics, 383

Intestine

acetylcholine in, 83

drug absorption in, age-related changes, 446

Intracellular interaction mechanism, 482

Ionic mechanisms, in heart muscle in relation to gen-

esis and pharmacological control of cardiac

arrhythmias, 5

Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 477

Jessell, Thomas M. See Fischbach et al., 411

Lacrimal glands, ion permeability control, 221Latt, Samuel A., Rhona R. Schreck, Kenneth S. Love-

day, and Charles F. Shuler. In vitro and invivo analysis of sister chromatid exchange,

501

Leucocytes, cholinergic system components in, 98Lidocaine action on cardiac membrane, 40

Ligand internalization and hormone action, 402

Ligand recognition site, distinction from enzymatic

catalytic site, 405

Lipid matrix, amphipathic, 371

Liver. See also Hepatic

adaptive changes that permit maintenance of lowconcentration of the toxic agent in (rat) (fig.),

355

autopsy specimen after injection with perfluorinatedparticles and colloidal gold (fig.), 581

correlation between content of polychlorinated bi-

phenyl and the mitochondrial #{246}-aminolevu-

linic acid synthetase activity (fig.), 356membrane permeability modulation by calcium and

cyclic AMP, 228morphological and biochemical data, relationship,

431response to drugs

model for assessment of, 430; (fig.), 431, 432, 433

morphometric analysis in assessment of, 429

Liver cellmouse

sister chromatid exchange in (fig.), 521

sister chromatid exchange induction in, by cyclo-phosphamide (fig.), 522

Liver microsomal drug metabolism (table), 458Liver necrosis, glutathione levels in liver, covalent

binding and, relationships with (table), 465

Liver protein, effect of diethyl maleate or cysteine on

covalent binding of acetaminophen to

(mouse) (table), 465

Loutzenhiser, R. See van Breemen et al., 167

Loveday, Kenneth S. See Latt et al., 501

Luteinizing hormone/follicle-stimulating hormone-re-

leasing hormone or luliberin, 257

e8tlmates of in vivo half-lives in rat, dog, pig, and

man (table), 257Luteinizing hormone-releasing hormone

blood concentrations

decay of, in vitro and in viva, 257

role of tissues in decay of, 258

Lymphocytes, cholinergic system components in, 97Lysinoalanine toxicity (fig.), 360

Lysosomal disease

glycogenesis type II, the prototype of, 566

in toxicology (workshop summary), 347

Lysosomal disorders, pro- and postnatal pathology,enzyme treatment, and unresolved issues in,565

Lysosomal enzyme activities in “normal” cultured fi-broblasts (table), 579

Lysosomal lipidosis

drug-induced, biochemical interpretations, 593

relationship to enzyme deficiency diseases, 593Lysosomes

function and dysfunction of, 565function of, as intracellular disposal system (fig.),

566

in toxicology (workshop summary), 347membrane stabilization with, 597

Lysosomotropism, 598

Mammalian cells

DNA fragmentation and DNA repair of, indicator

for complex interactions between carcinogens

and modulating factors, 493microbial and, application to assessment of muta-

genicity, 537models, 542

Manic depression, serum dopamine /3-hydroxylase ac-

tivity in, 158

Marchesi, Vincent T. Functional components of sur-

face membranes: Potential targets for phar-

macological manipulation, 371

Maturation and development, acetylcholine and, 118Meiotic cells, sister chromatid differentiation in, 522

a-Melanocyte-stimulating hormone, (melanostatin)

256, 259

Membrane. See also Cardiac, Cell, and Surface mem-

braneMembrane permeability, role of calcium in receptor

regulation of, 209

Membrane response to uniform current, 9Membrane systems of cytoplasm, implications for tox-

icology (workshop summary), 339

Metabolic activation procedures, 541

Metabolic conjugation, time-scale in discovery of (ta-

ble), 352Metabolism

acetaminophen, pathways of (fig.), 464

arachidonic acid, 295; (fig.), 294

bromobenzene, pathways of (fig.), 463

drug

624 INDEX

Metabolism-continued

in liver, age-dependent changes in, 448liver microsomal (table), 458

toxicological implications, 457nonmicrosomal hepatic, age-dependent changes

in, 453

endoperoxides, 319

halothane, oxidative and reductive pathways of,

schematic representation (fig.), 358

peptide hormone

arteriovenous differences in vivo, 250

blood and plasma in vitro, 250

blood or plasma kinetics in viva, 250

clearance processes involved in (table), 283comparison of, 279distribution studies in vivo, 250

isolated perfused organs and tissues, 250

processes involved in, 248prostacydlin, 320

testosterone, by rat liver microsomes, chiorthioneffect on (table), 460

thromboxane A2, 320

Metabolites, DNA- and chromosome-damaging cata-

lytic activity ofCu� ions on thiol compounds

in generating (table), 496

Metachromatic leucodystrophy (MW), 588

3-Methylcholanthrene, effect on liver microsomal cy-

tochrome P-450 and benzo(a)pyrene hydrox-

ylase activity (rat) (fig.), 459

Methylguanidine, nitrosation prevention by sodium

ascorbate (fig.), 494

Microbial cellassays, 537

mammalian and, application to assessment of mu-

tagenicity, 537

Mitochondria, effects ofthickening agents on oxidative

phosphorylation in (rat) (table), 609

Mitochondrial function, chemical interference with,606

Mitomycin C, sister chromatid exchanges in humanperipheral lymphocyte by (fig.), 506

Moncada, S., and J. R. Vane. Pharmacology and en-dogenous roles of prostaglandin endoperox-

ides, thromboxane A2, and prostacyclin, 293

Morphine and codeine, plasma concentrations after

oral aspirin-codeine phosphate combination(fig.), 462

Morphometry and the future, 441

Mucocutaneous membranes, cholinesterases in, 81Mucopolysaccharidosis type I (MPS I), Hurler’s die-

ease, 583

Mucosulfatidosis

cerebral cortex biopsy specimen in (fig.), 585

liver biopsy specimen of (fig.), 584multiple sulfatase deficiency, 588

Multiple sulfatase deficiency. See Mucosulfatidosis

Muscle. See Cardiac, Heart, Skeletal, and Smoothmuscle.

Musculotendinous junctions, acetylcholinesterase

concentration at, 80

Mutagenesis, implications for toxicology (workshop

summary), 344

Mutagemc activity, reduction of, by pretreatment with2,(3)tert-butyl-4-hydroxyanisole or coadmin-

istration of erythromycin (table), 550Mutagemc effects, protection from, of antischistoso-

mal and other drugs, 547Mutagenicity

application of microbial and mammalian cells to

assessment of, 537

testing procedures (table), 538testing requirements (table), 544

Mutagensantimutagens and, environmental, 359

environmental, sources (table), 361infood(table),361

Mutations, preadaptive, affecting the disposition of

and response to foreign compounds, 555Myocardial electrophysiology, 5

Mytilus edulis

components of cholinergic systems in gill plates of,

77

drug effects on ciliary movement of (table), 78

Neoplastic disease, serum dopamine fl-hydroxylase ac-

tivity in, 158

Nerve-muscle synapses

acetylcholine receptors and acetylcholinesterase ac-

cumulation at, 411

functionally identified, electron micrograph (fig.),

419Nerve structures, developing, properties of first and

second phases of cholinergic system in (ta-ble), 92

Nerves

hot spot induction, 418; (fig.), 416motor, induction of new receptor clusters, 416organisms and tissues without, components of cho-

linergic systems in, 75Nervous tissues, non-

acetylcholine roles in, 116

cholinergic systems in, 65Neuroblastoma

cholinergic system component in, 92serum dopamine ,8-hydroxylase activity in, 158

Neuroblasts, development of cholinergic system in, 91Neurohypophysial hormone. See under Hormone

Neurological disease, serum dopamine /1-hydroxylase

activity in, 157Neuromuscular junctions, adult, acetylcholine recep-

tors and acetylcholinesterase at, 411Neurotoxic activation (fig.), 359

Neurotoxicity of hexachiorophene and two stereoiso-

mers, chemical structures of (fig.), 607

Neutrophils, leukocyte function and receptor activa-tion, dependence upon calcium, 236

Newberne James W., Bernard Becker, William F.

Bousquet, Robert M. Diener, Jack E. Gray,

G. H. Hottendorf, Emil A. Pfitzer, Gregory S.

Probst, Virgil B. Robinson, Richard L Steel-

INDEX

man, and Robert J. van Ryzin. Summary of

the workshop on cellular and molecular tox-icology, 335

Non-nervous tissues. See Nervous tissues, non-Nuclear interaction, nature of, 483

Nucleosome, 469

Nucleus, steroid hormone interaction with, 477

Opiate receptor agonists, enkephalins and endorphins,251

Oxidative phosphorylation, effects of thickening

agents on, in rat mitochondria (table), 609

Oxytocin, 254

Pacemaker potential, mechanism of, 20; (fig.), 21

Pancreas

exocrine cells of, changes in surface area (fig.), 437

exocrine, role for calcium in modulating ion perme-

abilities in, 223

hormones of, 271

Parathyroid hormone. See under Hormone

Peptide, C-, 272

Peptide hormone. See under Hormone

Peptide hormone metabolism. See under MetabolismPermeability and acetylcholine, 117Permeability coupling, stimulus-. See Stimulus-perme-

ability coupling

Permeability, membrane. See Membrane permeabilityPfitzer, Emil A. See Newberne et al., 335

Pharmacogenetics

expansion of field to include commonly used drugs

and more subjects, 558pedigree of family indicating incidence of resistance

to coumarin anticoagulant drugs (fig.), 558with putative aberrant enzyme, mode of inheritance,

frequency, and drugs that can elicit the signsand symptoms of the disorder (table), 556

Phenacetin, inhibition ofacetaminophen-induced hep-

atotoxicity by (mouse) (table), 466

Phenobarbitaleffect on

liver microsomal cytochrome P.450, ethylmor-phine N-demethylase activity, and antipyrine

(rat) (fig.), 459

surface area of the endoplasmic reticulum andoxidative demethylase (fig.), 439, 440

Phospholipid composition of tissues, drug-inducedchanges in (table), 599

Phospholipid-drug complex formation, 596

Physical and chemical agents, homeostatic mecha-

nisms of a multicellular organism and its

adaptive responses to (fig.), 354

Pituitary, anterior, protein and glycoprotein hormonesof, 276

Placenta

cholinergic system in, 80

cow, acetyicholine-like activity in, 114human

acetylcholine, 103

and transport of chemicals across placenta as

625

function of gestation, 112, 113

effects on blood vessels, 109

receptor in, 109

synthesis in, precursors for, 108uptake by fragments of, 108

biogenic amines and other endogenous sub-stances, effect on perfusion pressure of (ta-

ble), 110choline acetyltransferases in, 103

cholinesterases in, 103drug interference with placental acetylcholine, ef-

fect on intrauterine fetal growth, 113monkey, choline acetyltransferase activity, 113mouse, choline acetyltransferase activity, 115

rabbit, acetylcholine-like substances in, 114rat, choline acetyltransferase activity, 115

species variation in cholinergic systems of, 115Placental lactogen, 277

Plants, cholinergic system in, 115

Plasma metabolism, tissue homogenates or slices, 250

Platelet aggregation, prostaglandin endoperoxides andthromboxane A2 in, 302

Plateletsacetylcholine and acetylcholine receptor in, 97acetylcholinesterase in, 96choline acetyltransferase activity in, 975-hydroxytryptamine, adenine nucleotides and ace-

tylcholinesterase release from, 97unstable derivatives of fatty acids in, 316

Point mutation assayseukaryotic microorganisms, 540

gene or, bacterial, 540

mammalian cell models, 542

Polychiorinated biphenyl, liver content of, correlationwith 6-aminolevulinic acid synthetase activ-ity (fig.), 356

Postnatal pathology in five lysosomal disorders, 565

Potassium currents, compounds influencing, 47; (fig.),

48

Prenatal pathology in five lysosomal disorders, 565

Procainamide, antiarrhythmic and arrhythmogenic

properties of, 39, 40Probst, Gregory S. See Newberne et al., 335

Proinsulin, 272

estimates of half-lives of, in the pig, baboon, and

man (table), 273Prolactin, 277

Prostacyclin, 306

metabolism of, 320

prostaglandin endoperoxides, thromboxane A2 and,pharmacology and endogenous roles of, 293

therapeutic potential of, 315thromboxane A2-thrombosis, hemostasis and, 313release and role in vascular homeostasis, 310thromboxane A2, imbalance in other pathological

states, 320

synthetase, 296tissues described in (table), 298

Prostaglandin endoperoxides

rabbit aorta contracting substance and, 296

626 INDEX

Prostaglandin endoperoxides-continued

thromboxane A2 and, in platelet aggregation, 302

prostacyclin and, pharmacology and endogenous

roles of, 293

Protein hormones of the anterior pituitary, 276Protein

mouse liver, effect of diethyl maleate or cysteine on

covalent binding ofacetaminophen to (table),465

“functional,” isolation and characterization of, 379

membrane, properties of, 373

pyrolysis products isolated from (fig.), 361

Protozoa, components of cholinergic systems in, 76Psychiatric disease, serum dopamine /3-hydroxylase

activity in, 158

Purkinje fiber, action potential (fig.), 23

Putney, James W., Jr. Stimulus-permeability coupling:

Role of calcium in the receptor regulation ofmembrane permeability, 209

Pyridine nucleotide, reduced form of, electron traits-

port to drug substrate (fig.), 458

Pyrolysis products from proteins, peptides and their

amino acids (fig.), 361

Quinidine, cardiac electrophysiological effects of, 39

Ray, Verne A. Application of microbial and mamma-

lian cells to the assessment of mutagemcity,

537Receptor. See also Acetylcholine, Hormone, Estrogen,

and Salivary glandactivation, 481

adenylate cyclase coupling, 406

studies, immunochemical approaches to, 487translocation, 480

mechanism, evidence for (table), 481

Red blood cellcalcium and regulation of membrane permeability

to K, 211

components of cholinergic system in, 79membrane, lipid bilayer, glycophorin A and, 376

Renal clearance of drugs, age-dependent changes in,

448

Renal disease, serum dopamine fl-hydroxylase activity

in, 156

Repolarization, underlying mechanisms, 22; (fig.), 23Reproductive system, prostacyclin in, 317Ribonucleic acid synthesis, estrogen-receptor corn-

plexes and, 485

Robinson, Virgil B. See Newberne et al., 335Rubin, Lee L. See Fischbach et al., 411

Sadavongvivad, C. See Sastry and Sadavongvivad, 65

Salarnanders, acetylcholine and limb regeneration in,

88

Salivary glandscalcium channel, nature of, 218calliphora, ion transport and water movement, con-

trol by membrane receptors, 226other ionic fluxes, 220

receptors; Ca and K flux, 214; (fig.), 216

stimulus-permeability coupling mechanisms, modelfor study, 214

San, R. H. C. See Stich et al., 493

Sarcolemma, cholinesterases in, 80, 81Sarcoplasm, cholinesterases in, 80,81Sastry, B. V. Rama, and C. Sadavongvivad. Choliner-

gic systems in non-nervous tissues, 65

Schizophrenia, serum dopamine f3-hydroxylase activ-

ity in, 158

Schmucker, Douglas L. Age-related changes in drug

disposition, 445

Schreck, Rhona R. See Latt et al., 501

Secretin, 265Shuetze, Stephen M. See Fischbach et al., 411

Shuler, Charles F. See Latt et al., 501

Singh, Bramah N. See Hauswirth and Singh, 5

Sister chromatid differentiation5-bromo-2’-deoxyuridine-dye techniques (fig.), 502

induction of, in Chinese hamster ovary chromo-

somes (fig.), 504

in meiotic cells, 522Sister chromatid exchange

agents capable of inducing, strongly positive (table),507

agents exhibiting mixed or weak induction behavior

(table), 516agents found not to induce (table), 519

analysis of, 501

basic information, 505

biological significance of formation of, 525

5-bromo-2’-deoxyuridine dye methodology for, 501

extension of studies of, from in vitro to in vivosystems, 505

formation of, in human chromosome fragility dis-

eases, 526human lymphocytes (fig.), 504

induction ofby clastogens, 505

in human peripheral lymphocyte by mitomycin C(fig.), 506

in mouse liver cells by cyclophosphamide (fig.),522

induction tests, interpretation of, 523in mouse liver cell (fig.), 521

mechanism of formation of, 528

relationship ofinduction of, to DNA damage, repair,and synthesis, 524

Sister chromatid interchange, evidence for, at the

DNA level, 528; (fig.), 529

Skeletal muscle, components of cholinergic systems in,80

Smooth muscleacetylcholine action in, 83

alimentary tractouabain and zero potassium, inhibition of sodium,

potassium adenosine triphosphatase, 188

potassium elevation, effects of, 183

sodium substitution experiments, 175mammalian, sodium-calcium interactions in, 167

mechanisms and coupling factors in membranepermeability, 231

INDEX 627

ureter

Na,K pump blockade, effects of, 199

sodium substitution, effects, 197

uterine

Na,K ATPase inhibition, effects of, 196

sodium substitution, 194

vascular

effects of sodium substitution, 170

sodium, potassium, and adenosine triphosphatase

inhibition, 173

Sodium-calcium interactions

in mammalian smooth muscle, 167

molecular mechanisms, 167; (fig.), 168

specific cellular sites for, 170

Sodium current, fast, compounds influencing, 37Sodium gradient and muscle tension, theoretical rela-

tionship between (fig.), 202

Somatostatin, 258

Somatotrophin, 276

Sperm

from various segments of epididymis, choline ace-

tyltransferase and acetylcholinesterase activ-

ities in, 99

human, effect of cholinergic and cholinergic block-ing drugs on motility of, 101

sea urchin, effects of cholinergic and cholinergicblocking agents on motility of sperm from,

100; (table), 101Spermatozoa

cholinergic system in, 79,80,98

sterility and, 102Sperm fractions, choline acetyltransferase and acetyl-

cholinesterase in, 100

Sperm motility, effects of cholinergic and cholinergicblocking agents on, 100

Spider, acetylcholine in silk glands of, 87

Spleen, acetylcholine and propionylcholine in, 84

Steelman, Richard L. See Newberne et a!., 335Sterility, spermatozoal cholinergic system and, 102Steroid and drug hydroxylation, requirements for (ta-

ble), 460Stich, H. F., R F. Whiting, L Wei, and R H. C. San.

DNA fragmentation and DNA repair of

mammalian cells as an indicator for the corn-plex interactions between carcinogens and

modulating factors, 493Stimulus-permeability coupling, role of calcium in re-

ceptor regulation of membrane permeability,

209

Stress, effects on serum dopamine /3-hydroxylase ac-

tivity, 151Surface membranes, functional components of, targets

for pharmacological manipulation, 371

Symposium, workshop on cellular and molecular tox-

icology, 335

Synaptic current

acetylcholine power spectra and, at neonatal andadult rat endplates (fig.), 422

decay, variation in rate of (fig.), 424

Tachyphylaxis and receptor regulation, 401

Target cells, estrogen-receptor interaction in, 479

Target tissues, hormone binding in, 478; (fig.), 478

Testosterone, chlorthion effect on metabolism of, byrat liver microsomes (table), 460

Tetrodotoxin, influence on fast sodium current, 37Thickening agents, effects of, on oxidative phoapho-

rylation in rat mitochondria (table), 609Thiol compounds, catalytic activity of Cu� ions on,

in generating DNA- and chromosome-dam-aging metabolites (table), 496

Thromboxane synthetase, 296Thromboxane A2, 301

metabolism of, 320

prostacydlin and, imbalance in other pathological

states, 320

prostaglandin endoperoxides and, in platelet aggre-

gation, 302

prostaglandin endoperoxides, prostacydlin and,

pharmacology and endogenous roles of, 293

-thrombosis, prostacydlin, and hemostasis, 313

synthetase, tissues described in (table), 2973H-Thymidine, radioactivity in rabbit sperm after in-

jection of (fig.), 613

Thyroid and parathyroid, calcium regulating hor-

mones of, 266

Thyroid disease, serum doparnine$-hydroxylase activ-

ity in, 159

Thyroliberin, 256

Thyrotropin-releasing hormone or thyroliberin, 256

Tissues

nonexcitable, calcium and receptor-mediated con-

trol of ion permeability, 233non-nervous, cholinergic systems in, 65

remote involvement with nervous system, compo-

nents of cholinergic systems in, 80

Torsion dystonia, serum dopamine �8-hydrozylase ac-

tivity in, 157

Toxic agents

in rat liver, adaptive changes that permit mainte-

nance of low concentration of (fig.), 355time scale in discovery of metabolic conjugation

(table), 352

Toxicant, interrelationships between sequence of bio-

chemical changes caused by, and associated

pathological events (fig.), 357Toxicity effect on homeostasis, 352Toxicological investigations, cell nucleus and related

factors�in (workshop summary), 342

Toxicological testing, scientific approaches to, 606

Toxicologyapplication of basic concepts to research in, 605

summary of workshop on, 347basic science in, request for more, 605cellular and molecular

summary of workshop on, 335

workshop on, 335

implications for

membrane systems of cytoplasm (workshop sum-

mary), 339

mutagenesis (workshop summary), 344on the cell surface (workshop summary), 336

�‘�±(“�1 Library

.- � . : � � :OSPITAL

628 INDEX

Toxicology-continued

lysosornal diseases in (workshop summary), 347

lysosomes in (workshop summary), 347

new era, 351

summary of workshop on, 335

pharrnacokinetic and metabolic considerations, 611pharmacological approach to, 610

Trachea, acetylcholine and cilia movement in (rabbit),82

Trophic factors and acetylcholine, 118

van Breemen, C., P. Aaronson, and R. Loutzenhieer.

Sodium-calcium interactions in mammaliansmooth muscle, 167

Vane, J. R. See Moncada and Vane, 293

van Ryzin, Robert J. See Newberne et aL, 335

Vasopressin, 254

Vesell, Elliot S. Intraspecies differences in frequency

of genes directly affecting drug disposition:

The individual factor in drug response, 555

Vinyl chloride, hepatic macromolecular binding andglutathione depression related to exposure to

(fig.), 357Voltage clamp versus standard electrophysiological

techniques, 37; (fig.), 37,38Wei, L. See Stich et al., 493

Weinshilboum, Richard M. Serum dopamine �-hy-droxylase, 133

Welch, Richard M. Toxicological implications of drug

metabolism, 457Whiting, R. F. See Stich et al., 493Workshop on cellular and molecular toxicology, 335

Zbinden, Gerhard. Application of basic concepts toresearch in toxicology, 605

Zonula occludens in mouse liver (fig.), 384, 385

629

0031-6997/79/3004-0629$02.O0/OPHARMACOLOGICAL REVIEWSCopyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics

Author Index

Pharmacological Reviews

Volumes 1-30

1949-1978

Vol. 30, No.4Printed in USA.

Abraham, E. P. The cephalosporins, 14, 473Adler, T. K. See Way and Adler, 12, 383

Aggeler, Paul M. See O’Reilly and Aggeler, 22, 35Ahiquist, R. P. The receptors for epinephrine and

norepinephrine, a discussion, 11, 441

Akera, Tai, and Brody, Theodore M. The role of

Na�,K�-ATPase in the inotropic action of digitalis,

29, 187

Albert, Adrien, Ionization, pH, and biological activity,4, 136

Allen, David G. See Blinks et al., 28, 1Allen, Julius C. See Schwartz et al., 27, 3

Ambache, N. Choline esters as local hormones, 6, 113

, The use and limitations of atropine for phar-

macological studies on autonomic effectors, 7, 467Anderson, Hamilton R., and Hansen, Eder L. The

chemotherapy of amebiasis, 2, 399

Andersson, Bengt, and Larsson, Stig. Physiological

and pharmacological aspects of the control of hun-ger and thirst, 13, 1

Angeletti, Piero U. See Levi-Mont.alcini and Angeletti,

18, 619Archer, J. A. See Gorden et al., 25, 179Ari#{235}ns, E. J., van Rossum, J. M., and Simonis, A. M.

Affinity, intrinsic activity, and drug interactions, 9,218

Armentrout, Steven A. See Beard et al., 21, 213Armstrong, Marvin D., and McMillan, Armand. Stud-

ies on the formation of 3-methoxy-4-hydroxy-D-

mandelic acid, a urinary metabolite of norepineph-

line and epinephrine, 11, 394

Ashmore, James. See Mayhew et al., 21, 183

Atack, C. V. See Carlsson et al., 24, 371

Aviado, Domingo M. The pharmacology of the pul-monary circulation, 12, 159

Axelrod, Julius. The metabolism of catecholamines in

viva and in vitro, 11, 402-, Methylation reactions in the formation and me-

tabolism of catecholamines and other biogenic

amines, 18, 95

, Dopamine-$-hydroxylase: regulation of its syn-

thesis and release from nerve terminals, 24, 233, See Glowinski and Axelrod, 18, 775, See Lemberger et al., 23, 371

Bacq, Z. M. Metabolism of adrenaline, 1, 1-, Summary ofdiscussion and commentary, 18, 313Baer, John E. See Beyer and Baer, 13, 417Baird, Joyce D. See Duncan and Baird, 12,91

Baker, J. B. E. The effects of drugs on the foetus, 12,37

Baliga, B. S. See Wurtman et aL, 24, 411

Banks, P., and Blaschko, H. Chromaffin tissue, 18, 453Barnes, J. M., and Denz, F. A. Experimental methods

used in determining chronic toxicity, 6, 191

-, and Stoner, H. B. The toxicology of tin com-

pounds, 11, 211

Batzinger, Robert P. See Bueding et al, 30, 547

Beard, N. Shelley, Jr., Armentrout, Steven A., andWeisberger, Austin S. Inhibition ofmaminalian pro-tein synthesis by antibiotics, 21, 213

Becker, Bernard. See Newberne et al., 30, 335Beecher, Henry K. The measurement of pain, 9, 59Beets, M. G. J. The molecular parameters of olfactory

response, 22, 1

Bein, H. J. The pharmacology of Rauwolfia, 8, 435Bell, Christopher. Autonomic nervous control of re-

production: circulatory and other factors. 24, 657Belleau, B. Steric effects in catecholamine interactions

with enzymes and receptors, 18, 131Bennett, Ivan L., Jr., and Cluff, Leighton E. Bacterial

pyrogens, 9, 427Berger, F. M. Spinal cord depressant drugs, 1, 243Bergstrom, Suite, Carbon, Lars A., and Weeks, James

R. The prostaglandins: a family ofbiologically active

lipids, 20, 1Berkowitz, Barry. See Spector et al., 24, 191

, See Spector et al., 25, 281

Berliner, David L., and Dougherty, Thomas F. Hepatic

and extrahepatic regulation of corticosteroids, 13,

329Berliner, Robert W., and Orloff, Jack. Carbonic an-

hydrase inhibitors, 8, 137

Bertaccini, Giulio. Active polypeptides of nonmam-malian orgin, 28, 127

Bertler, A., Falck, B., Owman, Ch., and Rosengrenn,

E. The localization of monoaminergic blood-brainbarrier mechanisms, 18, 369

Bertler, Ake, and Rosengren, Evald. Possible role of

brain dopamine, 18, 769

Beutler, Ernest. Drug-induced hemolytic anemia, 21,73

Beyer, Karl H. Functional characteristics of renaltransport mechanisms, 2, 227

, and Baer, John E. Physiological basis for theaction of newer diuretic agents, 13, 517

Bickel, M. H. The pharmacology and biochemistry of

N-oxides, 21, 325

630 AUTHOR INDEX, VOLUMES 1-30

Bigelow, G., Griffiths, R., and Liebson, I. Experimental

human drug self-administration: methodology and

application to the study of sedative abuse, 27, 523

Bishop, Charles, and Talbott, John H. Uric acid: itsrole in biological processes and the influence upon

it of physiological, pathological, and pharmacologi-cal agents, 5, 231

Bizzi, A. See Garattini and Bizzi, 18,243Bjur, R. See Weiner et al., 24, 203Blaschko, H. Amine oxidase and amine metabolism,

4, 415

-, Metabolism of epinephrine and norepinephrine,

6, 23, The development of current concepts of cate-

cholamine formations, 11, 307

, Chairman. First Session, Section I: Enzymology,

18, 39-84; Introductory remarks, 39

-, See Banks and Blaschko, 18,453Blinks, John R., and Koch-Weser, J. Physical factors

in the analysis of the actions of drugs on myocardial

contractility, 15, 531

, Prendergast, Franklyn G., and Allen, David G.

Photoproteins as biological calcium indicators,

28, 1

, See Koch-Weser and Blinks, 15,601Blohm, Thomas R Drug-induced lysosomal lipidosis:

biochemical interpretations, 30, 593

Bloom, Floyd E., Wedner, H. James, and Parker,

Charles W. The use of antibodies to study cell

structure and metabolism, 25, 343

Bobbin, Richard P. See Guth et al., 28, 95Bodansky, Oscar. Methemoglobinemia and methe-

moglobin-producing compounds, 3, 144

Bohr, David F. Electrolytes and smooth muscle con-

traction, 16, 85

Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to drugs, 30,429

Borison, Herbert L., and Wang, S. C. Physiology andpharmacology of vomiting, 5, 193

Boullin, D. J. See Costa et al., 18, 577Bousquet, William F. See Newberne et al., 30, 335

Bowman, Robert L. Fluorescence and its measure-ment, 11, 256

Bowman, W. C., and Nott, M. W. Actions of sympa-

thomimetic amines and their antagonists on skeletalmuscle, 21, 27

Boyd, Eldon M. Expectorants and respiratory tractfluid, 6, 521

Boyland, E. Mutagens, 6,345Brady, J. V. See Griffith et aL, 27,357Brand, J. J., and Perry, W. L M. Drugs used in motion

sickness. A critical review of the methods available

for the study of drugs of potential value in its

treatment and of the information which has beenderived by these methods, 18, 895

Braun-Menendez, E. Pharmacology of ream and hy-pertensin, 8, 25

Braunwald, Eugene. See Chidsey and Braunwald, 18,685

, See Higgins et al., 25, 119

Brawley, Peter, and Duffield, James C. The pharma-cology of hallucinogens, 24, 31

Brendel, K. See Breeder et al., 21, 105Bresnick, Edward. Report on the discussion of the

Third Session, 25, 315Bressler, R., Corredor, C., and Brendel, K. Hypoglycin

and hypoglycin-like compounds, 21, 105Brestkin, A. P. See Kabachnik et aL, 22, 355

Brink, Frank. The role of calcium ions in neural pro-cesses, 6, 243

Brodie, Bernard B., Davies, J. I., Hynie, S., Krishna,G., and Weiss, B. Interrelationships of catechol-amines with other endocrine systems, 18, 273

-, Spector, Sydney, and Shore, Parkhurst A. Inter-action ofdrugs with norepinephrine in the brain, 11,548

-, See Costa et al., 18, 577

Brody, Theodore M. The uncoupling of oxidative

phosphorylation as a mechanism of drug action, 7,335

-, Summary ofdiscussion and commentary, 18, 253

, See Akera and Brody, 29, 187

Brownlee, George. The wider aspects of the chemo-therapy of tuberculosis, 5, 421

Br#{252}cke, F. Dicholinesters ofa,�,-dicarboxylic acids and

related substances, 8, 265Bucher, K. Pathophysiology and pharmacology of

cough, 10, 43

Buchthal, Fritz. The effect of acetylcholine-like sub-stances on sensory receptors, 6, 97

Bueding, Ernest. Summary ofdiscussion and commen-tary, 18, 211

-, Batzinger, Robert P., Cha, Young-Nam, Talalay,

Paul, and Molineaux, Christopher J. Protectionfrom mutagenic effects of antischistosomal and

other drugs, 30, 547

�, and Swartzwelder, Clyde. Anthelmintics, 9, 329-, See Saz and Bueding, 18, 871Buffoni, F. Histaminase and related amine oxidases,

18, 163

Bunker, John P., Chairman, and Vandam, Leroy D.,

Co-chairman. Effects of anesthesia on metabolismand cellular functions: a workshop held under theCommittee on Anesthesia of the National Academy

of Sciences-National Research Council, 17, 183

Burgen, A. S. V. Central and sensory transmission, 6,95

Burn, J. H. Acetylcholine as a local hormone for ciliary

movement and the heart. 6, 107-, Chairman. Section V: Adrenergic transmission,

18, 459-540; Introductory remarks, 459Burnstock, G. Evolution of the autonomic innervation

of visceral and cardiovascular systems in verte-

brates, 21, 248, Purinergic nerves, 24, 509

-, and Holinan, Mollie E. Junction potentials at

adrenergic synapses, 18, 481

Bush, I. E. Chemical and biological factors in theactivity of adrenocortical steroids, 14, 317

AUTHOR INDEX, VOLUMES 1-30 631

Bushby, S. H. M. The chemotherapy ofleprosy, 10, 1Butcher, R. W. Cyclic 3’,S’-AMP and the lipolytic

effects of hormones on adipose tissue, 18, 237Butler, Thomas C. Theories of general anesthesia, 2,

121Butler, Vincent P., Jr. The immunological assay of

drugs, 29, 103-, Watson, John F., Schmidt, Donald H., Gardner,

Jerry D., Mandel, William J., and Skelton, C. Lynn.

Reversal of the pharmacological and toxic effects of

cardiac glycosides by specific antibodies, 25, 239

Cafruny, Edward J. The site and mechanism of actionof mercurial diuretics, 20, 89

Calabresi, Paul. Report on the discussion ofthe Fourth

Session, 25, 359Campbell, T. Cohn, and Hayes, Johnnie R. Role of

nutrition in the drug-metabolizing enzyme system,26, 171

Canaan, Lars A. Blood and tissue changes induced bynorepinephrine-stimulated mobilization offree fatty

acid, 18, 241

-‘ See Bergstrom et al., 20, 1Carbon, Loren D. The role of catecholamines in cold

adaptation, 18, 291

Carlsson, Arvid. Detection and assay of dopamine, 11,300

-, The occurrence, distribution, and physiological

role of catecholamines in the nervous system, 11,

490

-, Pharmacological depletion of catecholamine

stores, 18, 541

-, Kehr, W., Lindqvist, M., Magnusson, T. and

Atack, C. V. Regulation of monoamine metabolism

in the central nervous system, 24, 371Can, Edward A. Drug allergy, 6, 365

Case, Rosemary. Obituary, 18,6Catania, A. C. Drug effects and concurrent perfor-

mances, 27, 385Cha, Young-Nam. See Bueding et al., 30, 547

Chenoweth, Maynard B. Monofluoroacetic acid andrelated compounds, 1, 383

-, Chelation as a mechanism of pharmacologicalaction, 8, 57

, and McCarty, L. P. On the mechanisms of thepharmacophoric effect of halogenation, 15, 673

Chidsey, Charles A., and Braunwald, Eugene. Sym-pathetic activity and neurotransmitter depletion in

congestive heart failure, 18, 685China, Herman I., and Smith, Paul K. Motion sick-

ness, 7, 33Christenson, James G. See Dairman et al., 24,266Clark, J. M., and Lambertsen, C. J. Pulmonary oxygen

toxicity: a review, 23, 39Clark, W. G. Studies on inhibition of L-dopa decarboz-

ylase in vitro and in vivo, 11, 330

Clarkson, T. W. See Passow et al., 13, 185

Cloutier, G. See Weiner et al., 24, 203

Cluff, Leighton E. See Bennett and Cluff, 9, 427Code, Charles F. The inhibition of gastric secretion: a

review, 3, 59Cohen, Gerald. Techniques to improve the specificity

of the trihydroxyindole procedure, 11, 269

Cole, Jonathan 0. See Kierman and Cole, 17, 101

Conney, A. H. Pharmacological implications of micro-somal enzyme induction, 19, 317

Cooper, Theodore. Surgical sympathectomy and ad-renergic function, 18, 611

Con, Carl, Chairman. Carbohydrate Metabolism, See-tion II: Metabolic Effects of Catecholamines, 18,

145-213

, See Helmreich and Cori, 18, 189Corredor, C. See Bressler et aL, 21, 105

Costa, E., Boullin, D. J., Hammer, W., Vogel, W., andBrodie, B. B. Interactions of drugs with adrenergicneurons, 18, 577

-, Green, A. R, Koslow, S. H., LeFevre, H. F.,

Revuelta, A. V., and Wang, C. Dopamine and nor-

epinephrmne in noradrenergic axons: a study in vivo

oftheir precursor product relationship by mass frag-

mentography and radiochemistry, 24, 167Crout, J. Richard. Some spectrophotofluorimetric ob-

servations on blood and urine catecholamine assays,

11, 296

, Pheochromocytoma, 18,651Curtis, D. R The pharmacology of central and periph-

eral inhibition, 15, 333, and Watkins, J. C. The pharmacology of amino

acids related to gamma-aminobutyric acid, 17, 347

Cuthbert, A. W. Membrane lipids and drug action, 19,

59

Dahlstr#{246}m, Annica. See Hillarp et al., 18, 727

Dairman, Wallace, Christenson, James G., and Uden-

friend, Sidney. Changes in tyrosine hydroxylase anddopa decarboxylase induced by pharmacological

agents, 24, 266

Dale, Sir Henry H. The beginnings and the prospects

of neurohumoral transmission, 6, 7Dalgaard-Mikkelsen, Sv., and Poulsen, Emil. Toxicol-

ogy of herbicides, 14, 225Daly, M. de Burgh. Acetylcholine and transmission at

chemoreceptors, 6, 79

Dam, Henrik. Influence of antioxidants and redox

substances on signs of vitamin E deficiency, 9, 1Daniels-Severs, Anne E. See Severs and Daniels-Sev-

era, 25, 415

Danowski, T. S., and Elkinton, J. R. Exchanges of

potassium related to organs and systems, 3, 42Darken, Marjorie A. Puromycin inhibition of protein

synthesis, 16, 223Davies, B. N., and Withrington, P. G. The actions of

drugs on the smooth muscle of the capsule andblood vessels of the spleen, 25, 373

Davies, J. I. See Brodie et al., 18, 273Davis, Jean P. See Toman and Davis, 1, 425Dawes, G. S. Experimental cardiac arrhythmias and

quinidine-like drugs, 4,43de Champlain, Jacques. Report on the discussion of

the Fourth Session, 24, 431

632 AUTHOR INDEX, VOLUMES 1-30

DeLange, Robert J. See Krebs et al., 18, 163

Delmonte, Lilian, and Jukes, Thomas H. Folic acidantagonists in cancer chemotherapy, 14, 91

De Matteis, F. Disturbances of liver porphyrin metab-

olism caused by drugs, 19, 523Dengler, Hans J. See Titus and Dengler, 18, 525

De Robertis, Eduardo. Adrenergic endings and vesi-des isolated from brain, 18, 413

de Wied, D. Chiorpromazine and endocrine function,19, 251

Dews, P. B. Introduction: Schedule-induced polydipsiaand oral intake of drugs, 27, 447

, Are the techniques and results of studies of self-administration of drugs useful in other areas of

psychobiology, 27, 545

Diener, Robert M. See Newberne et al., 30, 335

Doak, George 0. See Eagle and Doak, 3, 107Domino, Edward F., Hardman, Harold F., and Seevers,

Maurice H. Central nervous system actions of some

synthetic tetrahydrocannabinol derivatives, 23, 317

, See Hardman et al., 23, 295

Dontas, A. S. See Hoobler and Dontas, 5, 135Dorfman, Albert. Metabolism of the mucopolysaccha-

rides of connective tissue, 7, 1

Dornhorst, A. C. Adrenergic blockade in cardiovascu-lar disease, 18, 701

Dougherty, Thomas F. See Berliner and Dougherty,

13, 329

Douglas, W. W. Is there chemical transmission at

chemoreceptors?, 6, 81

, The mechanism of release of catecholamines

from the adrenal medulla, 18, 471

Downs, D. A., and Woods, J. H. Naloxone as a negative

reinforcer in rhesus monkeys: effects of dose, sched-

ule, and narcotic regimen, 27, 397Drill, Victor A. Hepatotoxic agents: mechanism of

action and dietary interrelationship, 4, 1Duncan, Leslie J. P., and Baird, Joyce D. Compounds

administered orally in the treatment of diabetesmellitus, 12, 91

Duffield, James C. See Brawley and Duffield 24, 31Dustin, P., Jr. New aspects of the pharmacology of

antimitotic agents, 15, 449

Dyrenfurth, I. See Vande Wiele and Dyrenfurth, 25,

189

Eagle, Harry, and Doak, George 0. The biologicalactivity of arsenosobenzenes in relation to their

structure, 3, 107Edvinsson, Lars, and MacKenzie, Eric T. Amine mech-

anisms in the cerebral circulation, 28, 275

Ehrenpreis, Seymour, Fleisch, Jerome H., and Mittag,

Thomas W. Approaches to the molecular nature ofpharmacological receptors, 21, 131

Eldjarn, Lorentz. See Pihi and Eldjarn, 10, 437Elion, G. B. See Hitchings and Elion, 15, 365

Elkinton, J. R. See Danowski and Elkinton, 3, 42Ellis, Sydney. The metabolic effects of epinephrine

and related amines, 8, 485

, Relation of biochemical effects of epinephrine to

its muscular effects, 11, 469Elmadjian, Fred. Excretion and metabolism of epi-

nephrmne, 11, 409

Emmelin, N. Supersensitivity following “pharmaco-

logical denervation,” 13, 17Engbaeck, Lisa. The pharmacological actions of mag-

nesium ions with particular reference to the neuro-

muscular and the cardiovascular system, 4, 396

Er#{228}nk#{246},Olavi. Demonstration of catecholamines andcholinesterases in the same section, 18, 353

Erlanger, Bernard F. Principles and methods for the

preparation of drug protein conjugates for immu-nological studies, 25, 271

Erspamer, V. Pharmacology of indoleakylamines, 6,

425

Exton, J. H., and Park, C. H. The stimulation of

gluconeogenesis from lactate by epinephrine, glu-

cagon, and cyclic 3’,5’-adenylate in the perfused ratliver, 18, 181

Fain, John N. Biochemical aspects of drug and hor-

mone action on adipose tissue, 25, 67Fairhurst, Alan S. See Jenden and Fairhurst, 21, 1Falck, B. See Bertler et al., 18, 369

Falk, J. L., and Samson, H. H. Schedule-induced phys-ical dependence on ethanol, 27, 449

F#{228}nge,H. Pharmacology ofpoikilothermic vertebratesand invertebrates, 14, 281

Fastier, F. N. Structure-activity relationships of aim-dine derivatives, 14, 37

Featherstone, H. M., and Muehlbaecher, C. A. The

current role of inert gases in the search for anesthe-

sia mechanisms, 15, 97

Feldberg, W. S. Central and sensory transmission, 6,

85Feldberg, W., Chairman. Section VIII: Adrenergic

Mechanisms in the Nervous System, 18, 713-803Introductory remarks, 713

Fischbach, Gerald D., Frank, Eric, Jessell, ThomasM., Rubin, Lee L., and Schuetze, Stephen M. Ac-cumulation of acetyicholine receptors and acetyl-

cholinesterase at newly formed nerve-muscle syn-

apses, 30, 411Fisher, James W. Erythropoietin: pharmacology, bio-

genesis, and control of production, 24, 459Fleisch, Jerome, H. See Ehrenpreis et al., 21, 131Flesch, P. Inhibition of keratinizing structures by sys-

temic drugs, 15, 653Flower, Roderick J. Drugs which inhibit prostaglandin

biosynthesis, 26, 33

Flynn, Edward J. See Spector et al., 25, 281Forney, Robert B. Toxicology of marihuana, 23, 279

Fox, B. N., and Fox, Margaret. Biochemical aspects ofthe actions of drugs on spermatogenesis, 19, 21

Fox, Margaret. See Fox, B. N., and Fox, Margaret, 19,21

Frank, Eric. See Fischbach et al., 30, 411Franklin, Edward C. Report on the discussion of the

Second Session, 25, 269

Fraser, H. F. See Isbell and Fraser, 2, 355

AUTHOR INDEX, VOLUMES 1-30 633

Freedman, Daniel X. See Giarman and Freedman, 17,

1

French, J. E. See Robinson and French, 12, 241

Freyburger, Walter A. See Moe and Freyburger, 2, 61Friedenwald, Jonas S. Histochemistry-a review, 7,83

Friedman, Stanley. See Kaufman and Friedman, 17,71

Furchgott, Robert F. The pharmacology of vascular

smooth muscle, 7, 183

-, The receptors for epinephrine and norepineph-

rime (adrenergic receptors), 11, 429

-, Summary ofdiscussion and commentary, 18,641Fuxe, Kjell. See Goldstein et a!., 24, 293

-, See Hillarp et al., 18, 727

Gaddum, Sir John H. Bioassays and mathematics, 5,87

-, Theories of drug antagonism, 9, 211-, Bioassay procedures, 11, 241

, Obituary, 18, 5Gale, E. F. Mechanisms of antibiotic action, 15, 481Garattini, S., and Bizzi, A. Effect of drugs on mobili-

zation of free fatty acid, 18, 243

Gardner, Jerry D. See Butler et al., 25, 239Gavin, J. R., III. See Gorden et al., 25, 179Gerard, R. W. Closing remarks to symposium on neu-

rohumoral transmission, 6, 123Germuth, Frederick G., Jr. The role of adrenocortical

steroids in infection, immunity, and hypersensitiv-ity, 8, 1

Giarman, Nicholas J., and Freedman, Daniel X. Bio-chemical aspects of the actions of psychotomimetic

drugs, 17, 1

Gibbins, R. J� See Kalant et al., 23, 135

Gill, C. A. See Holz and Gill, 27, 437

Gillespie, J. S. Summary of discussion and commen-

tary, 18, 537Gilman, Alfred, and Koelle, G. B. Anticholinesterase

drugs, 1, 166

Ginsborg, B. L. Ion movements in junctional traits-mission, 19, 289

Gitlow, S. E. Summary ofdiscussion and commentary,

18, 707

Glaval, E. See Nikodijevi#{233} et a!., 18, 705Glick, Seymour M. Report on the discussion of the

First Session, 25, 209

Glowmski, J., and Axelrod, J. Effects of drugs on the

disposition of H3-norepinephrmne in the rat brain,

18, 775

Glowinski, Jacques, and Baldessarini, Ross J. Metab-

olism of norepinephrine in the central nervous sys-

tern, 18, 1201

Glynn, I. M. The action of cardiac glycosides on ionmovements, 16, 381

Godovikov, N. N. See Kabachnik et al., 22, 355

Goffart, M. The action of l-noradrenaline and adre-

nochrome on unfatigued mammalian muscle, 6, 33Golberg, Leon. Keynote Address. Toxicology: Has a

new era dawned?, 30, 351

Goldberg, Leon I. Cardiovascular and renal actions of

dopamine: potential clinical applications, 24, 1

Goldberg, S. R. Stimuli associated with drug injections

as events that control behavior, 27, 325, and Kelleher, R. T. Introduction: schedules of

termination of drug injections, 27, 395

, See Kelleher and Goldberg, 27, 291, 341

Goldfien, Alan. Effects of glucose deprivation on the

sympathetic outflow to the adrenal medulla and

adipose tissue, 18, 303

Goldstein, Avram. Interactions of drugs and plasma

proteins, 1, 102

Goldstein, M. Inhibition of norepinephrine biosyn-thesis at the dopamine-$-hydroxylation stage, 18,

77, Fuxe, K., and H#{246}kfelt, T. Characterization and

tissue localization ofcatecholamine synthesizing en-

zymes, 24, 293

Goodall, McC. Metabolic products of adrenaline andnoradrenaline in human urine, 11, 416

Goodenough, Daniel A. Gap junction dynamics andintercellular communication, 30, 383

Gorden, P., Gavin, J. R., ifi, Kahn, C. R., Archer, J.A., Lesniak, M., Hendricks, C., Neville, D. M., Jr.,

and Roth, J. Application of radioreceptor assay to

circulating insulin, growth hormone, and to theirtissue receptors in animals and man, 25, 179

Gorkin, V. Z. Monoamine oxidases, 18, 115Goz, Barry. The effects of incorporation of 5-haloge-

nated deoxyuridines into the DNA of eukaryotic

cells, 29, 249

Graessle, Otto E. See Molitor and Graessle, 2, 1Grant, W. Morton. Physiological and pharmacological

influences upon intraocular pressure, 7, 143Gray, Jack E. See Newberne et al., 30, 335

Green, A. R. See Costa et al., 24, 167

Griffith, R. R., Wurster, R. M., and Brady, J. V.

Discrete-trial choice procedure: effects of naloxoneand methadone on choice between food and heroin,27, 357

Griffiths, R. See Bigelow et al., 27, 523Grub, Mary A. Electron microscopy of sympathetic

tissues, 18, 387

Guldberg, Hans C., and Marsden, Charles A. Catechol-0-methyl transferase. Pharmacological aspects and

physiological role, 27, 135

Gunnison, Janet B. See Jawetz and Gunnison, 5, 175Guth, Paul S., Norris, Charles H., and Bobbin, Richard

P. The pharmacology of transmission in the periph-

eral auditory system, 28, 95

Gyermek, Laszlo. 5-Hydroxytryptamine antagonists,

13, 399

Haag, H. B. See Silvette et al., 14, 137

Haber, Edgar, Chairman. Cardiovascular Applica-

tions, The role of antibodies and physiological re-

ceptors in cardiovascular diagnosis, therapy, andresearch, 25, 215

-, See Smith, T. W., and Haber, 25, 219Haddy, Francis J. See Visscher et aL, 8, 389

Hagen, P. The storage and release of catecholamines,

634 AUTHOR INDEX, VOLUMES 1-30

11, 361

Haggendal, Jan. Newer developments in catechol-

amine assay, 18, 325

Hahn, F. Analeptics, 12, 447

Hajdu, Stephen, and Leonard, Edward. The cellularbasis of cardiac glycoside action, 11, 173

Hammer, W. See Costa et al., 18, 577Hansen, Eder L. See Anderson and Hansen, 2, 399

Hardman, Harold F., Domino, Edward F., and Seevers,

Maurice H. General pharmacological actions of

some synthetic tetrahydrocannabinol derivatives,

23, 295

-, See Domino et al., 23, 317Hartman, Boyd K., and Udenfriend, Sidney. The ap-

plication of immunological techniques to the studyof enzymes regulating catecholamine synthesis and

degradation, 24, 311Harris, Louis S. General and behavioral pharmacol-

ogy, 23, 285

Hasselbach, Wilhelm, and Weber, Annemarie. Models

for the study of the contraction of muscle and of cell

protoplasm, 7, 97Haugaard, Niels, and Hess, Marilyn E. Actions of

autonomic drugs on phosphorylase activity and

function, 17, 27-, and Hess, Marilyn E. The influence of catechol-

amines on heart function and phosphorylase activ-

ity, 18, 197

-, Kukovetz, Walther R., and Hess, Marilyn E. The

effect ofsympathomimetic amines on phosphorylaseactivity of the isolated rat heart, 11, 466

Hawking, Frank. The chemotherapy of filarial infec-

tions, 7, 279Hawkins, Rosemary D. The metabolism of ethanol

and its metabolic effects, 24, 67Hayaishi, Osamu. Enzymic studies on the mechanism

of double hydroxylation, 18, 71Hayes, Johnnie R. See Campbell and Hayes, 26, 171

Hebb, Catherine 0. Acetylcholine metabolism of ner-

vous tissue, 6, 39Heinle, Robert W. See Welch and Heinle, 3, 345

Hellon, R. F. Monoamines, pyrogens, and cations:

their action on central control of body temperature,

26, 289

Helmreich, Ernst, and Cori, Carl F. The activation of

glycolysis in frog sartorius muscle by epinephrine,18, 189

Hendricks, C. See Gorden et al., 25, 179

Hertz, Leif. Drug-induced alterations of ion distribu-

tion at the cellular level of the central nervous

system, 29, 35Hess, Marilyn E. See Haug#{225}ard and Hess, 17,27

-‘ See Haugaard and Hess, 18, 197, See Haugaard et al., 11, 466

Heymans, C. Action of drugs on carotid body andsinus, 7, 119

Higgins, Charles B., Vatner, Stephen F., and Braun-wald, Eugene. Parasympathetic control ofthe heart,

25, 119

Hillarp, Nils-Ake. Obituary, 18, 5

-, Fuxe, Kjell, and Dahlstrdm, Annica. Demonstra-

tion and mapping of central neurons containing

dopamine, noradrenaline, and 5-hydroxytryptamineand their reactions to psychopharmaca, 18, 727

Himms-Hagen, Jean. Sympathetic regulation of me-

tabolism, 19, 367

Hitchings, G. H., and Elion, G. B. Chemical suppres-sion of the immune response, 15, 365

Hoff, E. C. See Silvette et al., 14, 137Hoffmeister, F., and Wuttke, W. Psychotropic drugs

as negative reinforcers, 27, 419

H#{246}kfelt, T. See Goldstein et al., 24, 293

Hollenberg, Morley D. Hormone receptor interactionsat the cell membrane, 30, 393

Hollister, Leo E. Actions of various marihuana deriv-atives in man, 23, 349

Holman, Mollie E. See Burnstock and Holman, 18,481

Holmstedt, Ba. The action of anticholinesterases on

spinal reflexes following intraarterial injection, 6,49

, Pharmacology of organophosphorus cholinester-

ass inhibitors, 11, 567Holtz, Peter. Role of L-dopa decarboxylase in the

biosynthesis of catecholamines in nervous tissue andthe adrenal medulla, 11, 317

, Chairman. Second Session, Section I: Enzymol-ogy, 18, 85-144; Introductory remarks, 85

-, and Palm, Dieter. Pharmacological aspects of

vitamin B�, 16, 113

Holz, W. C., and Gill, C. A. Drug injections as negative

reinforcers, 27, 437

Hoobler, S. W., and Dontas, A. S. Drug treatment of

hypertension, 5, 135Hornykiewicz, Oleh. Dopamine (3-hydroxytyramine)

and brain function, 18, 925Horowicz, Paul. The effects of anions on excitable

cells, 16, 193

Hottendorf, G. H. See Newberne et al., 30, 335

Hug, George. Pro- and postnatal pathology, enzyme

treatment, and unresolved issues in five lysosomaldisorders, 30, 565

Hull, R See Hurst and Hull, 8,199Hunt, Carlton C., and Kuffler, Stephen W. Pharma-

cology of the neuromuscular junction, 2, 96Hunter, F. Edmund, Jr., and Lowry, Oliver H. The

effects of drugs on enzyme systems, 8, 89Hurst, E. Weston, and Hull, R. The chemotherapy of

virus diseases, with brief consideration of the influ-

ence of dietary, hormonal, and other factors in virus

infection, 8, 199

Hynie, S. See Brodie et al., 18, 273

Iglauer, C., Liewellyn, M. E., and Woods, J. H. Currentschedules of cocaine injection in rhesus monkeys:

dose variation under independent and non-indepen-dent variable-interval procedures, 27, 367

Ingram, G. I. C. Anticoagulant therapy, 13, 279Isbell, Harris, Chairman. Marihuana and Its Surro-

gates, Session II, 23, 337-380

Clinical pharmacology of marihuana, 337

AUTHOR INDEX, VOLUMES 1-30 635

-, and Fraser, H. F. Addiction to analgesics andbarbiturates, 2, 355

Jackson, H. Antifertility substances, 11, 135

Jacobowitz, David W. See Kostrzewa and Jacobowitz,26, 199

Jacobsen, Erik. The metabolism of ethyl alcohol, 4,107

Jawetz, Ernest, and Gunnison, Janet B. Antibioticsynergism and antagonism: an assessment of theproblem, 5, 175

Jenden, Donald J., and Fairhurst, Alan S. The phar-macology of ryanodine, 21, 1

Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 30, 477

Jessell, Thomas M. See Fischbach et al., 30, 411Johanson, C. E. Pharmacological and environmental

variables affecting drug preference in rhesus mon-

keys, 27, 343

Johanseon, B#{246}rje.See Meliander and Johansson, 20,117

Johns, Anthony. See Paton et al., 29, 67Jones, Reese T. Marihuana-induced “high”: influence

of expectation, setting, and previous drug experi-

ence, 23, 359

Jukes, Thomas H., and Williams, William L. Nutri-tional effects of antibiotics, 5,381

-‘ See Delmonte and Jukes, 14, 91

Kabachnik, M. I., Brestkin, A. P., Godovikov, N. N.,Michelson, M. J., Rozengart, E. V., and Rozengart,

V. I. Hydrophobic areas on the active surface ofcholinesterases, 22, 355

Kahn, C. R. See Gorden et al., 25, 179Kalant, H., LeBlanc, A. E., and Gibbins, R J. Toler-

ance to, and dependence on some non-opiate psy-

chotropic drugs, 23, 135Kao, C. Y. Tetrodotoxin, saxitoxin, and their signifi-

cance in the study of excitation phenomena, 18,997Kappas, A., and Palmer, R. H. Selected aspects of

steroid pharmacology, 15, 123Karlson, Peter. See Sekeris and Karlson, 18, 89

K#{227}ser,Hans. Catecholamine-producing neural tumorsother than pheochromocytoma, 18, 659

Kaufman, Seymour. Coenzymes and hydroxylases:

ascorbate and dopamine-fl-hydroxylase; tetrahy-

dropteridines and phenylalanine and tyrosine hy-droxylases, 18, 61

-, and Friedman, Stanley. Dopamine-/1-hydroxyl-ass, 17, 71

Kehr, W. See Carlsson et al., 24, 371

Kelleher, R. T. Characteristics of behavior controlled

by scheduled injections of drugs, 27,307

-‘ and Goldberg, S. R. General introduction: controlof drug-taking behavior by schedules of reinforce-

ment, 27, 291

-‘ and Goldberg, S. R. Introduction: Complexschedules of drug injection, 27, 341

-, See Goldberg and Kelleher, 27, 395Kemp, Robert G. See Krebs et al., 18, 163

Kety, Seymour S. The theory and applications of the

exchange of inert gas at the lungs and tissues, 3, 1

-, Central actions of catecholamines, a discussion,

11, 565

-, Catecholamines in neuropsychiatric states, 18,787

-, Chairman. First Session, Increased Synthesis ofCatecholamines without Changes in Enzyme Levels,24, 167-224

Khromov-Borisov, N. V., and Michelson, M. J. Themutual disposition of cholinoreceptors of locomotor

muscles, and the changes in their disposition in the

course of evolution, 18, 1051

Kiese, Manfred. The biochemical production of fern-hemoglobin-forming derivatives from aromatic

amines, and mechanisms of ferrihemoglobin forms-

tion, 18, 1091

Killam, Eva King. Drug action on the brain-stemreticular formation, 14, 175

Kimura, Kazuo K. See Randall and Kimura, 7, 365Kiplinger, Glenn F., and Manno, Joseph E. Dose-re-

spouse relationships to cannabis in human subjects,23, 339

Kirshner, Norman. Biosynthesis of adrenaline andnoradrenaline, 11, 350

-, Summary of discussion and commentary, 18, 83-, and Viveros, 0. H. The secretory cycle in the

adrenal medulla, 24, 385Kizer, John S., Youngbbood, William W., and Nemer-

off, Charles B. Neurotoxic amino acids and struc-turally related analogs, 29, 301

Klaus, Wolfgang. See Lee and Klaus, 23, 193Klerman, Gerald L, and Cole, Jonathan 0. Clinical

pharmacology of imipramine and related antide-

pressant compounds, 17, 101Koch-Weser, J., and Blinks, J. R. The influence of the

interval between beats on myocardial contractility,

15, 601

, See Blinks and Koch-Weser, 15,531Koelle, George B. The localization of specific cholin-

esterase in the retina, 6, 47-, Possible mechanisms for the termination of the

physiological actions of cateeholamines, 11, 381

-, Summary of discussion and commentary, 18,359

-, See Gilman and Koelle, 1,166Kopin, Irwin J. Storage and metabolism of catechol-

amines: the role of monoamine oxidase, 16, 179-, Biochemical aspects ofrelease of norepinephrine

and other amines from sympathetic nerve endings,

18, 513

-, and Silberstein, Stephen D. Axons of sympa-thetic neurons: transport of enzymes in viva andproperties of axonal sprouts in vitro, 24, 245

-‘ See Lemberger et al., 23, 371Koslow, S. H. See Costa et al., 24, 167Kosterlitz, H. W., and Lees, G. M. Pharmacological

analysis of intrinsic intestinal reflexes, 16,301Kostrzewa, Richard M., and Jacobowitz, David W.

Pharmacological actions of6-hydroxydopamine, 26,199

636 AUTHOR INDEX, VOLUMES 1-30

Krasnegor, N. A. Introduction: behavioral factors in

human drug abuse, 27,499Krebs, Edwin G., DeLange, Robert L, Kemp, Robert

G., and Riley, W. Dixon. Activation ofskeletal mus-

cle phosphorylase, 18, 163

Krishna, G. See Brodie et al., 18, 273Krsti#{233},M. See Varagl#{233} and Krsti#{233},18,799Kuffler, Stephen W. See Hurtt and Kuffler, 2,96Kukovetz, Walther R. See Haugaard et al., 11,466

Laemmli, U. K. Levels of organization of the DNA in

eucaryotic chromosomes, 30, 469Lambertsen, C. J. See Clark and Lambertsen, 23,39

Lande, Saul, and Lerner, Aaron B. The biochemistryof melanotropic agents, 19, 1

Lands, A. M. The pharmacological activity of epineph-rune and related dihydroxyphenylalkylamines, 1, 279

Larson, P. 5. See Silvette et al., 14, 137

Larsson, Stig. See Andersson and Larsson, 13, 1Lasagna, Louis. The clinical evaluation of morphine

and its substitutes as analgesics, 16, 47Laties, Victor G. See Weiss and Laties, 14, 1

Latt, Samuel A., Schreck, Rhona R., Loveday, Ken-neth S., and Shuler, Charles F. In vitro and in vivo

analysis of sister chromatid exchange, 30, 501

Lurell, C.-B. Plasma iron and the transport of iron in

the organism, 4, 371

Leander, J. D., and McMillan, D. E. Schedule-induced

narcotic ingestion, 27, 475

LeBlanc, A. E. See Kalant et al., 23, 135

Lee, Kwang S., and Klaus, Wolfgang. The subcellularbasis for the mechanism of inotropic action of car-

disc glycosides, 23, 193Leeper, Lemuel C. Catecholamine formation in intact

tissues, 11, 358

Lees, G. M. See Kosterlitz and Lees, 16,301

LeFevre, H. F. See Costa et aL, 24, 167

LeFevre, Paul G. Sugar transport in the red blood cell:structure-activity relationships in substrates and an-

tagonists, 13, 39

Letkowitz, Robert J. Isolated beta-adrenergic binding

sites: a potential assay vehicle for catecholamines,

25, 259

Lemberger, Louis, Axelrod, Julius, and Kopin, Irwin

J. Metabolism and disposition of �9-tetrahydrocan-

nabinol in man, 23, 371Leonard, Edward. See Hajdu and Leonard, 11, 173Lerner, Aaron B. See Lande and Lerner, 19, 1Lesniak, M. See Gorden et al., 25, 179Levi-Montalcini, Rita, and Angeletti, Piero U. Immu-

nosympathectomy, 18, 619

Levine, Lawrence. Antibodies to pharmacologicallyactive molecules: specificities and some applications

of antiprostaglandins, 25,293Lieberman, Seymour, and Teich, Sylvia. Recent trends

in the biochemistry of the steroid hormones, 5, 285Liebson, I. See Bigelow et aL, 27, 523

Lilienthal, Joseph L., Jr. Carbon monoxide, 2, 324Liljestrand, G. Transmission at chemoreceptors, 6,73

Lindenbaum, John. Bioavailability of digoxin tablets,

25, 229

Lindenmayer, George E. See Schwartz et al., 27, 3Lindqvist, M. See Carlsson et al., 24, 371

Llewellyn, M. E. See Iglauer et aL, 27, 367Loewe, S. Antagonism and antagonists, 9, 237Loewi, Otto. Introduction to symposium on neurohu-

moral transmission, 6, 3Longo, V. G. Behavioral and electroencephalographic

effects of atropine and related compounds, 18, 965

Loveday, Kenneth S. See Latt et aL, 30, 501

Lowry, Oliver H. See Hunter and Lowry, 8,89Lundholm, Lennart, Chairman. Physiological Interre-

lationships, Section II: Metabolic Effects of Cate-cholamines, 18, 255-314; Introductory remarks, 255

MacKenzie, Eric T. See Edvinsson and MacKenzie,

28, 275

Magnusson, T. See Carlsson et al., 24, 371Makinodan, T., Santos, G. W., and Quinn, R. P. Irs-

munosuppressive drugs, 22, 189

Maloof, F., and Soodak, M. Intermediary metabolismof thyroid tissue and the action of drugs, 15, 43

Mandel, H. George. The physiological disposition of

some anticancer agents, 11, 743

Mandel, William J. See Butler et al., 25, 239

Manger, William Muir. Suitability of the ethylenedi-

amine method of Weil-Maiherbe and Bone andmodifications for quantitating plasma pressor

amines, 11, 289

Manno, Joseph E. See Kiplinger and Manno, 23, 339

Mansour, Tag E. Actions ofserotonin and epinephrine

on intact and broken cell preparations from the liver

fluke, Fasciola hepatica, 11,465-, Factors influencing activation of phosphofruc-

tokinase, 18, 173

Marchesi, Vincent T. Functional components of sur-face membranes: potential targets for pharmacolog-

ical manipulation, 30, 371Marley, E. Behavioural and electrophysiological ef-

fects of catecholamines, 18, 753Marrazzi, A. S. Ganglionic and central transmission, 6,

105

Marsden, Charles A. See Guldberg and Marsden, 27,135

Marshall, E. K., Jr. The dosage schedule of chemo-

therapeutic agents, 4,85Martin, W. R. Opioid antagonists, 19, 463

Matthews, R. E. F. Biosynthetic incorporation of me-

tabolite analogues, 10,359Mautner, Henry G. The molecular basis ofdrug action,

19, 107

Mayhew, Dale A., Wright, Peter H., and Ashmore,James. Regulation of insulin secretion, 21, 183

Maynert, E. W. Summary of discussion and commen-tary, 18, 457

, and van Dyke, H. B. The metabolism of barbi-turates, 1, 217

McCarty, L P. See Chenoweth and McCarty, 15, 673

Mcintyre, A. K. Central and sensory transmission, 6,103

AUTHOR INDEX, VOLUMES 1-30 637

McKearney, J. W. Drug effects and the environmental

control of behavior, 27, 429

McLean, Elizabeth K. The toxic actions of pyrrolizi-dine (Senecio) alkaloids, 22, 429

McMillan, Armand. See Armstrong and McMillan, 11,

394

McMillan, D. E. See Leander and McMillan, 27, 475

Meisch, R. A. The function of schedule-induced poly-

dipsia in establishing ethanol as a positive reinfor-

cer, 27, 465

Meldrum, B. S. The actions of snake venoms on nerve

and muscle. The pharmacology of phospholipase A

and of polypeptide toxins, 17, 393

Mellander, Stefan, and Johansson, B#{246}rje.Control ofresistance, exchange, and capacitance functions in

the peripheral circulation, 20, 117

Mello, N. K. Schedule-induced polydipsia and oral

intake of drugs, 27, 489

Michelson, M. J. See Khromov-Borisov and Michel-

son, 18, 1051

, See Kabachnik et al., 22, 355Miller, D. D. See Patil et al., 26, 323Miller, Elizabeth C., and Miller, James A�Mechanisms

of chemical carcinogenesis: nature of proximate car-

cinogens and interactions with macromolecules, 18,

805

Miller, James A. See Miller, E. C., and Miller, J. A.,

18, 805

Millican, R. Carl. See Rosenthal and Millican, 6,489

Mittag, Thomas W. See Ehrenpreis et al., 21, 131Miyamoto, Michael D. The actions of cholinergic

drugs on motor nerve terminals, 29, 221Moe, Gordon K., and Freyburger, Walter A. Gangli-

onic blocking agents, 2, 61

Mohme-Lundholm, Ella. See Lundholm et al., 18, 255Molineaux, Christopher J. See Bueding et al., 30, 547

Molitor, Hans, and Graessle, Otto E. Pharmacologyand toxicology of antibiotics, 2, 1

Moran, Neil C. Pharmacological characterization ofadrenergic receptors, 18, 503

Mordes, John P., and Wacker, Warren E. C. Excessmagnesium, 29, 273

Morse, W. H. Introduction: the control of behavior byconsequent drug injections, 27, 301

-, See Tang and Morse, 27, 407

Muehlbaecher, C. A. See Featherstone and Muehl-baecher, 15, 97

Musacchio, Jose M. Report on the discussion of the

Third Session, 24, 361Muscholl, E. Indirectly acting sympathomimetic

amines, 18, 551Mustard, J. F., and Packham, M. A. Factors influenc-

ing platelet function: adhesion, release, and aggre-

gation, 22, 97

Nahas, Gabriel G. The pharmacology of tris-

(hydroxymethyl)aminomethane (THAM), 14, 447Neff, Norton H. Report on the discussion of the First

Session, 24, 223Nemeroff, Charles B. See Kizer et al., 29, 301

Neville, D. M., Jr. See Gorden et al., 25, 179

Newberne, James W., Becker, Bernard, Bousquet,

William F., Diener, RObert M., Gray, Jack E., Hot-tendorf, G. H., Pfitzer, Emil A., Probst, Gregory S.,

Robinson, Virgil B., Steelman, Richard L., and van

Ryzin, Robert J. Summary of the workshop, 30, 335

Nickerson, Mark. Pharmacology of adrenergic block-ade, 1, 27

-, Nonequiibrium drug antagonism, 9, 246

, Blockade of the actions of adrenaline and nor-

adrenaline, 11, 443

, Summary of discussion and commentary, 18,801

Nikodijevi#{233}, B., Glava�, E., and Polenakovi#{233}, M. Car-

diovascular effects of monoamine oxidase inhibitors,

18, 705

Noble, R. L. Hormonal regulation of tumor growth, 9,

367

Norberg, Karl-Axe!, and Sjoqvist, Folke. New possi-bilities for adrenergic modulation of ganglionic

transmission, 18, 743Norris, Charles H. See Guth et aL, 28, 95Nott, M. W. See Bowman and Nott, 21, 27

O’Brien, C. P. Experimental analysis of conditioningfactors in human narcotic addiction, 27, 533

Olson, James Allen. The metabolism ofvitamin A, 19,

559

O’Reilly, Robert A., and Aggeler, Paul M. Determi-nants of the response to oral anticoagulant drugs in

man, 22, 35Orloff, Jack. See Berliner and Orloff, 8, 137Oswald, Ian. Drugs and sleep, 20, 273

Ottoson, D. Some aspects of the function of the olfac-

tory system, 15, 1

Owman, Ch. Methodology of fluorescense microscopyof catecholamines, 18, 351

, See Bertler et al., 18, 369

Packham, M. A. See Mustard and Packham, 22,97Paintal, A. S. Effects of drugs on vertebrate mecha-

noreceptors, 16, 341

Palm, Dieter. See Holtz and Palm, 16, 113Palmer, R. H. See Kappas and Palmer, 15, 123Pappano, Achilles J. Ontogenetic development of au-

tonomic neuroeffector transmission and transmitter

reactivity in embryonic and fetal hearts, 29, 3

Park, C. R. See Exton and Park, 18, 181

Park, W. K. See Regoli et ci., 26, 69

Parker, Charles W., Chairman. Fourth Session, 25,319-362

, The immunotherapy of cancer, 25, 325

, See Bloom et al., 25, 343

Parrot, Jean-Louis. The place of histamine in neuro-

humoral transmission, 6, 119Passow, H., Rothstein, A., and Clarkson, T. W. The

general pharmacology of the heavy metals, 13, 185

Patil, P. N., Miller, D. D., and Trendelenburg, U.

Molecular geometry and adrenergic drug activity,

26, 323

Paton, David M., Widdicombe, Jonathan H.,

638 AUTHOR INDEX, VOLUMES 1-30

Rheaume, Dorianne E., and Johns, Anthony. Therole of adrenergic innervation of the oviduct in the

regulation of mammalian ovum transport, 29, 67-, and Zaimis, Eleanor J. The methonium com-

pounds, 4, 219

Paton, W. D. Transmission and block in autonomic

ganglia, 6, 59, Histamine release by compounds of simple

chemical structure, 9, 269

Peart, W. S. The renin-angiotensin system, 17, 143

-, Catecholamines and hypertension, 18,667

Pekkarinen, Aimo. Adrenaline and noradrenaline inblood and urine, 6, 35

Perry, W. L. M. Transmission at the motor endplateand ganglionic synapse, 6, 71

-, See Brand and Perry, 18, 895Peskar, Bernard. See Spector et al., 25, 281

Peters, Lawrence. Renal tubular excretion of organic

bases, 12, 1Pfeffer, R. I. See Weiner et al., 24, 203

Pfitzer, Emil A. See Newberne et al., 30, 335

Philips, Frederick S. Recent contributions to the phar-

macology of bis(2-haloethyl) amines and sulphides,2, 281

Pickford, Mary. Antidiuretic substances, 4, 254

Pilil, Alexander, and Eldjarn, Lorentz. Pharmacologi-

cal aspects of ionizing radiation and of chemical

protection in mammals, 10, 437Pitts, Robert F., and Sartorius, Otto W. Mechanism of

action and therapeutic use of diuretics, 2, 161Plaa, Gabriel L., and Priestly, Brian G. Intrahepatic

cholestasis induced by drugs and chemicals, 28, 207

Pletscher, Alfred. Monoamine oxidase inhibitors, 18,121

, Regulation of catecholamine turnover by vans-tions of enzyme levels, 24, 225

-, Chairman. Second Session, Induction or Reduc-tion of Catecholamine Enzymes, 24, 225-292

Pohorecky, Larisaa A., and Wurtman, Richard J.Adrenocortical control of epinephrine synthesis,

23, 1

-, See Wurtman et al., 24, 411Polenakovi#{233}, M. See Nikodijevi#{233} et al., 18, 705

Porter, Curt C. See Stone and Porter, 18,569Potter, Lincoln T. Storage of norepinephrmne in sym-

pathetic nerves, 18, 439

Poulsen, Emil. See Dalgaard-Mikkelsen and Poulsen,14, 225

Pouslen, Knud. Measurements of renin-angiotensin-

aldosterone, 25, 249

Powell, C. E. See Slater and Powell, 11, 462

Prendergast, Franklyn G. See Blinks et al., 28, 1Price, Henry L. Estimation of epinephrine and nor-

epinephrine concentrations in human plasma by thetrihydroxyindole method, 11, 273

Priestly, Brian G. See Plan and Priestly, 28,207Probst, Gregory S. See Newberne et al., 30, 335

Prusoff, William H. Recent advances in chemotherapyof viral diseases, 19, 209

Quay, W. B. Indole derivative of pineal and relatedneural and retinal tissues, 17, 321

Quinn, R. P. See Makinodan et al., 22, 189

Hall, Theodore W. Role of adenosine 3’,5’-monophos-

phate (cyclic AMP) in actions of catecholamines,

24, 399

-, and Sutherland, E. W., Jr. Action of epinephrine

and norepinephrmne in broken cell preparations, 11,464

, See Sutherland and Rail, 12, 265

Randall, Walter C., and Kimura, Kazuo K. The phar-macology of sweating, 7, 365

Raikov#{225}, Helena, and Van#{232}�ek,Jill. Pharmacology of

bacterial toxins, 16, 1

Ray, Verne A. Application of microbial and mamma-lian cells to the assessment of mutagenicity, 30, 537

Recknagel, Richard 0. Carbon tetrachioride hepato-toxicity, 19, 145

Regoli, D., Park, W. K., and Rioux, F. Pharmacology

of angiotensin, 26, 69Rerup, Claus C. Drugs producing diabetes through

damage of the insulin secreting cells, 22, 485Revuelta, A. V. See Costa et al., 24, 167Rheaume, Dorianne E. See Paton et al., 29, 67Riggs, Douglas S. Quantitative aspects of iodine me-

tabolism in man, 4, 284

Hiker, Walter F., Jr. Excitatory and anti-curare prop-

erties of acetylcholine and related quaternary am-monium compounds at the neuromuscular junction,5, 1

Riley, James F. Pharmacology and functions of themast cells, 7, 267

Riley, W. Dixon. See Krebs et al., 18, 163Rioux, F. See Regoli et al., 26, 69

Robinson, D. S., and French, J. E. Heparin, the clear-ing factor lipase, and fat transport, 12, 241

Robinson, Virgil B. See Newberne et al., 30, 335Robison, G. Alan. See Sutherland and Robison, 18,

145

Robson, J. M., and Suffivan, F. M. Antituberculosis

drugs, 15, 169

Roche e Silva, M. Kinetics of recovery from inhibitionby antihistaminics, atropine, and antispasmodics, 9,

259

Roe, Aluf. The metabolism and toxicity of methanol,7, 399

Rosenberg, Thomas. See Wilbrandt and Rosenberg,

13, 109

Rosengren, Evald. See Bertler and Rosengren, 18, 769Rosengrenn, E. See Bertler et al., 18, 369Rosenthal, Sanford M., and Millican, R. Carl. The role

of fluids, electrolytes, and plasma proteins in exper-imental traumatic shock and hemorrhage, 6,489

Roth, J. See Gorden et al., 25, 179Rothballer, Alan B. The effects of catecholamines on

the central nervous system, 11,494Rothstein, A. See Passow et al., 13, 185

Rozengat, E. V. See Kabachnik et al., 22, 355

AUTHOR INDEX, VOLUMES 1-30 639

Rozengart, V. I. See Kabachnik et al., 22,355Rubin, Lee L. See Fischbach et al., 30, 411

Rubin, R. P. The role of calcium in the release ofneurotransmitter substances and hormones, 22,389

Ruthven, C. R. J. See Sandier and Ruthven, 18, 343

Sadler, P. W. Chemotherapy of viral diseases, 15,407Salmoiraghi, G. C. Central adrenergic synapses, 18,

717

Samson, H. H. See Falk and Samson, 27,449

San, R. H. C. See Stich et aL, 30, 493Sandier, Merton, Chairman. Third Session: Multiple

Forms and Localization of Enzymes, 24, 293-364-, and Ruthven, C. R. J. The measurement of 4-

hydroxy-3-methoxymandelic acid and homovanillicacid, 18, 343

-, and Youdim, M. B. H. Multiple forms of mono-

amine oxidase: functional significance, 24, 331Sandow, Alexander, Excitation-contraction coupling

in skeletal muscle, 17, 265

Santos, G. W. See MakinOdan et al., 22, 189Sartorius, Otto W. See Pitts and Sartorius, 2, 161

Sawyer, Wilbur H. Neurohypophysical hormones, 13,225

Saz, Howard J., and Bueding, Ernest. Relationshipsbetween anthelinintic effects and biochemical and

physiological mechanisms, 18, 871Schanker, Lewis S. Passage ofdrugs across body mem-

branes, 14, 501

Scheinberg, I. Herbert, and Sternlieb, Irmin. Copper

metabolism, 12, 355Scheline, Ronald R. Metabolism offoreign compounds

by gastrointestinal microorganisms, 25, 451

Schild, H. 0. Drug antagonism and pAx, 9, 242-, Calcium and the relaxant effect of isoproterenol

in the depolarized rat uterus, 18, 495Schmidt, Donald H. See Butler et al., 25, 239

Schmucker, Douglas L Age-related changes in drug

disposition, 30, 445Schou, Jens. Absorption of drugs from subcutaneous

connective tissue, 13, 441

Schou, Mogens. Biology and pharmacology of the

lithium ion, 9, 17

Schreck, Rhona R. See Latt et al., 30, 501

Schuetze, Stephen M. See Fischbach et al., 30, 411Schumann, Hans-Joachim. Medullary particles, 18,

433

Schuster, C. R. Drugs as reinforcers in monkey and

man, 27, 511Schwartz, Arnold, Lindenmayer, George E., and Allen,

Julius C. The sodium-potassium adenosine triphos-

phatase: pharmacological, physiological, and bio-

chemical aspects, 27, 3Seegers, Walter H. The influence of certain drugs on

blood coagulation and related phenomena, 3, 278Seaman, Philip. The membrane actions of anesthetics

and tranquilizers, 24, 583Seevers, Maurice H. See Domino et al., 23, 317

-, See Hardman et al., 23, 295

Sekeris, Constantin E., and Karlson, Peter. Biosyn-

thesis of catecholamines in insects, 18, 89

Severs, Walter B., and Daniels-Severs, Anne E. Effects

of angiotensin on the central nervous sytem, 25, 415Shanes, Abraham M. Electrochemical aspects of phys-

iological and pharmacological action in excitablecells, 10, 59

-, Electrochemical aspects of physiological and

pharmacological action in excitable cells. Part H.

The action potential and excitation, 10, 165

Shaw, F. H. Transmission and block in sympathetic

ganglia, 6, 69Shaw, James H. Caries-inhibiting agents, 11, 705Shideman, F. F., Chairman. Section VI: Modification

of Sympathetic Function, 18, 541-644

Shore, Parkhurst A. A simple technique involving

solvent extraction for the estimation of norepineph-

line and epinephrine in tissues, 11, 276, Release of serotonin and catecholamines by

drugs, 14, 531

-, The mechanism of norepinephrine depletion byreserpine, merataminol, and related agents. The role

of monoamine oxidase, 18,561, See Brodie et al., 11, 548

Shuler, Charles F. See Latt et al., 30, 501

Silberstein, Stephen D. See Kipin and Silberstein, 24,245

Silvette, H., Hoff, E. C., Larson, P. 5., and Haag, H. B.

The actions of nicotine on central nervous systemfunctions, 14, 137

Simonis, A. M. See Ari#{235}nset al, 9, 218

Siskind, Gregory W. Manipulation of the immune

response, 25, 319

Sjoerdsma, Albert. Catecholamine metabolism in pa-

tients with pheochromocytoma, 11, 374-, Chairman. Section VII: Catecholamines and the

Circulatory System, 18,645-712

, Catecholamine-drug interactions in man, 18, 673

Sj#{246}qvist, Folke. See Norberg and Sjoqvist, 18, 743Skelton, C. Lynn. See Butler et al., 25, 239Slater, I. H., and Powell, C. E. Some aspects of block-

ade of inhibitory adrenergic receptors or adrenocep-

tive sites, a discussion, 11, 462

Smith, A. D. Subcellular localization of noradrenaline

in sympathetic neurons, 24, 435

Smith, Elizabeth R. B. See Weil-Maiherbe and Smith,18, 331

Smith, Paul K. Certain aspects of the pharmacology

of the salicylates, 1, 353, See China and Smith, P. K., 7,33

Smith, Thomas W., and Haber, Edgar. Digitalis. Chit-

ical value of the radioimmunoassay of the digitalis

glycosides, 25, 219Snyder, Solomon H. Report on the discussion of the

Second Session, 24, 291

Sokoloff, Louis. The action of drugs on the cerebralcirculation, 11, 1

Somlyo, A. P., and Somlyo, A. V. Vascular smoothmuscles. I. Normal structure, pathology, biochem-

640 AUTHOR INDEX, VOLUMES 1-30

istry, and biophysics, 20, 197

, and Somlyo, A. V. Vascular smooth muscle. II.

Pharmacology of normal and hypertensive vessels,22, 249

Somlyo, A. V. See Somlyo, A. P., and Somlyo, A. V.,

20, 197

, See Somlyo, A. P., and Somlyo, A. V., 22, 249

Soodak, M. See Maloof and Soodak, 15,43

Sourkes, Theodore L. Dopa decarboxylase: substrates,

coenzyme, inhibitors, 18, 53-, Influence of specific nutrients on catecholamine

synthesis and metabolism, 24, 349

Spaziani, Eugene. Accesory reproductive organs in

mammals: control of cell and tissue transport by sex

hormones, 27, 207Spector, Sydney. Inhibitors of endogenous catechol-

amine biosynthesis, 18, 599

, Chairman. Third Session, 25, 271-318

-, Berkowitz, Barry, Flynn, Edward J., and Peskar,

Bernard. Antibodies to morphine, barbiturates, and

serotonin, 25, 281

-, Taver, James, and Berkowitz, Barry. Effects of

drugs and physiological factors in the disposition ofcatecholamines in blood vessels, 24, 191

, See Brodie et al., 11, 548

Spector, W. G. Substances which affect capillarypermeability, 10, 475

Sperber, Ivar. Secretion of organic anions in the for-

mation of urine and bile, 11, 109

Steelman, Richard L. See Newberne et al., 30, 335

Steinberg, Daniel. Catecholamine stimulation of fatmobilization and its metabolic consequences, 18, 217

Steiner, Alton. Radioimmunoassay for the cyclic nu-cleotides, 25, 309

Stephens, Gwen. See Visscher et al., 8, 389

Sternlieb, Irmin. See Scheinberg and Sternlieb, 12,355

Stich, H. F., Whiting, R. F., Wei, L, and San, R. H. C.

DNA fragmentation and DNA repair of mammaliancells as an indicator for the complex interactions

between carcinogens and modulating factors, 30, 493

Stitzel, Robert E. The biological fate of reserpine, 28,179

Stj#{228}rne, Lennart. Storage particles in noradrenergic

tissues, 18, 425Stone, Clement A., and Porter, Curt C. Methyldopa

and adrenergic nerve function, 18, 569

Stoner, H. B. See Barnes and Stoner, 11, 211Storrie, V. M. See Vanderlaan and Storrie, 7,301

Sullivan, F. M. See Robson and Sullivan, 15, 169Sutherland, Earl W., and Rail, T. W. The relation of

adenosine-3’,5’-phosphate and phosphorylase to the

actions of catecholamines and other hormones, 12,

265

, and Robison, G. Alan. The role of cyclic 3’,5’-

AMP in responses to catecholamines and other hor-mones, 18, 145

, See Rall and Sutherland, Jr., 11, 464

Svedmyr, Nils. See Lundholm et al., 18,255Swartzwelder, Clyde. See Bueding and Swartzwelder,

9, 329

Tabor, Celia W. See Tabor, H., and Tabor, C. W., 16,245

Tabor, Herbert. Metabolic studies on histidine, hista-

mine, and related imidazoles, 6, 299

-, and Tabor, Celia W. Spermidine, spermine, and

related amines, 16, 245

Talalay, Paul. See Bueding et al., 30, 547

Talbott, John H. See Bishop and Talbott, 5, 231

Tang, A. H., and Morse, W. H. Termination of a

schedule complex associated with intravenous injec-tions of nalorphine in morphine-dependent rhesus

monkeys, 27, 407

Tarver, James. See Spector et al., 24, 191Taylor, Dermot B. Some basic aspects of the phar-

macology of synthetic curariform drugs, 3, 412Teich, Sylvia. See Lieberman and Teich, 5, 285

Tepperman, Helen M. See Tepperman, J., and Tep-

perman, H. M., 12, 301

Tepperman, Jay, and Tepperman, Helen M. Someeffects of hormones on cells and cell constituents,12, 301

Thoenen, Hans. Comparison between the effect ofneuronal activity and nerve growth factor on the

enzymes involved in the synthesis of norepinephrine,24, 255

Thron, C. D. Linearity and superposition in pharma-

cokinetics, 26, 3Titus, Elwood, and Dengler, Hans J. The mechanism

of uptake of norepinephrine, 18, 525

Toman, James E. P. Neuropharmacology of peripheral

nerve, 4, 168

�, and Davis, Jean P. The effects of drugs upon the

electrical activity of the brain, 1, 425Trautwein, W. Generation and conduction of impulses

in the heart as affected by drugs, 15, 277

Trendelenburg, U. Supersensitivity and subsensitivity

to sympathomimetic amities, 15, 225-, Mechanisms of supersensitivity and subsensitiv-

ity to sympathomimetic amines, 18, 629

, See Patil et al., 26, 323Truitt, Edward B., Jr. Biological disposition of tetra-

hydrocannabinols, 23, 273

Udenfriend, Sidney. Survey of chemical and physicalmethods for measuring catecholamines, 11, 252

, Tyrosine hydroxylase, 18, 43

, Molecular biology of the sympathetic nervoussystem, 24, 165

, See Dairman et al., 24, 266

-, See Hartman and Udenfriend, 24, 311

Umbreit, W. W. Mechanisms of antibacterial action,5, 275

Uvn#{228}s,B#{246}rje.Antidromic vasodilatation in the paw of

the cat, 6, 99

Vandam, Leroy D. See Bunker and Vandam, 17,183

Vanderlaan, W. P., and Storrie, V. M. A survey of the

factors controlling thyroid function, with especial

reference to newer views on antithyroid substances,

7, 301

Vande Wiele, R. L., and Dyrenfurth, I. Gonadotropin-

AUTHOR INDEX, VOLUMES 1-30 641

steroid interrelationships, 25, 189

van Dyke, H. B. See Maynert and van Dyke, 1, 217

Vane, J. R. The estimation of catecholamines by bio-

logical assay, 18, 317

Van#{232}#{233}ek,Ji�’I. See Ra�kov#{225} and Ven#{233}#{232}ek,16, 1

van Rossum, J. M. See Ari#{246}nset al., 9, 218van Ryzin, Robert J. See Newberne et al., 30, 335

Vaagi#{233}, V., and Krsti#{233}, M. Adrenergic activation by

anticholinesterases, 18, 799

Vatner, Stephen F. See Higgins et al., 25, 119

Vaughan, M., Chairman. Lipid Metabolism, Section

II: Metabolic Effects ofCatecholamines, 18,215-254

Introductory remarks, 215

Vaughan Williams, E. M. The mode of action of drugs

upon intestinal motility, 6, 159Veldstra, H. Synergism and potentiation with special

reference to the combination ofstructural analogues,

8, 339

Vesell, Elliot S. Intraspecies differences in frequency

of genes directly affecting drug disposition: the in-

dividual factor in drug response, 30, 555

Visscher, Maurice B., Haddy, Francis J., and Stephens,

Gwen. The physiology and pharmacology of lungedema, 8, 389

Viveros, 0. H. See Kirshner and Viveros, 24, 385Vogel, W. See Costa et aL, 18, 577

Vogt, Marthe. Norepinephrine and epinephrine in the

central nervous system, 6, 31

-, Points to be considered in running chromato-grams of tissue extracts, 11, 249

-, Catecholamines in brain, 11,483

, Chairman. Section III: Measurement and Detec-

tion ofCatecholamines and Related Compounds, 18,315-364; Introductory remarks, 315

Vogt, Walther. Darmstoff, a gut-stimulating com-pound occurring in the intestinal wall, 6, 117

-, Naturally occurring lipid-soluble acids of phar-macological interest, 10,407

-, Activation, activities, and pharmacologically ac-tive products of complement, 26, 125

Volle, Robert L. Modification by drugs of synaptic

mechanisms in autonomic ganglia, 18,839

-, Guest Editor. Conversations in pharmacology,29, 185

von Euler, Curt. Physiology and pharmacology of tern-

perature regulation, 13, 361von Euler, Ulf S. The nature of adrenergic nerve

mediators, 3, 247-, Adrenaline and noradrenalin. Distribution and

action, 6, 15-, The development and applications of the trihy-

droxyindole method for catecholamines, 11, 262-, Twenty years of noradrenaline, 18, 29-, Chairman. Section IV: Properties of Adrenergic

Tissues, 18, 365-458; Introductory remarks, 365

-, Chairman. Fourth Session: Hormonal Interac-tions, 24, 365-430

-, Regulation of catecholamine metabolism in thesympathetic nervous system, 24, 365

von Studnitz, Wilfred. Chemistry and pharmacologyof catecholamine-secreting tumors, 18,645

Wacker, Warren E. C. See Mordes and Wacker, 29,

273

Wailer, Coy W. Chemistry of marihuana, 23,265

Walop, J. N. The metabolism of acetylcholine, 6, 45

Wang, C. See Costa et al., 24, 167

Wang, S. C. See Borison and Wang, 5, 193

Waser, Peter G. Chemistry and pharmacology of mus-

carine, muscarone, and some related compounds, 13,465

Watkins, J. C. See Curtis and Watkins, 17,347

Watson, John F. See Butler et al., 25, 239

Waud, D. R. Pharmacological receptors, 20, 49

Way, E. Leong, Chairman. Marihuana and It’� Surro-

gates, Session I., 23, 263-336; Cannabis Prelude, 2R.�l-, and Adler, T. K. The pharmacologic implications

of the fate of morphine and its surrogates, J “, 383

Weatherall, M. Drugs and porphyrin metabolism, 6,133

Weber, Annemarie. See Hasselbach and Weber, 7, 97Wedner, H. James. See Bloom et al., 25, 343

Weeks, James R. See Bergstrom et aL, 20, 1W#{233}gria, Ren#{233}.Pharmacology of the coronary circula-

tion, 3, 197Wei, L. See Stich et al., 30, 493

Weil-Malherbe, H. The fluorimetric estimation of cat-echol compounds by the ethylenediamine conden-

sation method, 11, 278-, and Smith, Elizabeth R. B. The estimation of

metanephrine, normetanephrine, and 3,4-dihydrox-ymandelic acid in urine, 18, 331

Weiner, N., Cloutier, G., Bjur, R., and Pfeffer, R. I.Modification of norepinephrine synthesis in intacttissue by drugs and during short-term adrenergic

nerve stimulation, 24, 203Weisberger, Austin S. See Beard, Jr. et at., 21, 213Weisburger, Elizabeth K. See Weisburger, J. H., and

Weisburger, E. K., 25, 1Weisburger, John H., and Weisburger, Elizabeth K.

Biochemical formation and pharmacological, taxi-cological, and pathological properties of hydroxyl-

amines and hydroxamic acids, 25, 1Weiss, Bernard, and Laties, Victor G. Enhancement of

human performance by caffeine and the amphet-amines, 14, 1

, See Brodie et al., 18, 273

Welch, Arnold D., and Heinle, Robert W. Hematopoi-etic agents in macrocytic anemias, 3, 345

Welch, Richard M. Toxicological implications of drug

metabolism, 30,457West, G. B. The distribution and metabolism of adre-

nergic mediators, 6, 29Whiting, R. F. See Stich et al., 30, 493Whittaker, V. P. Catecholamine storage particles in

the central nervous system, 18,401Widdicombe, Jonathan H. See Paton et aL, 29, 67

Wieland, Otto. See Wieland, T., and Wieland, 0., 11,87

Wieland, Theodor, and Wieland, Otto. Chemistry andtoxicology of the toxins of Amanita phalloides, 11,87

Wilder, Abraham. Sites and mechanisms of action of

642 AUTHOR INDEX, VOLUMES 1-30

morphine and related drugs in the central nervous

system, 2, 435

Wilhelm, D. L The mediation of increased vascular

permeability in inflammation, 14,251Willbrandt, Walther, and Rosenberg, Thomas. The

concept of carrier transport and its corollaries in

pharmacology, 13, 109

Williams, William L See Jukes and Williams, 5,381Williamson, John R. Kinetic studies of epinephrine

effects in the perfused rat heart, 18,205Winterstein, Hans. The actions of substances intro-

duced into the cerebrospinal fluid and the problem

of intracranial chemoreceptors, 13, 71

Withrington, P. G. See Davies and Withrington, 25,

373

Wolf, Stewart. The pharmacology ofplacebos, 11,689

Wollenberger, Albert. The energy metabolism of the

failing heart and the metabolic action of the cardiacglycosides, 1, 311

Woodbury, Dixon M. Relation between the adrenal

cortex and the central nervous system, 10, 275Woods, J. H. See Downs and Woods, 27, 397

-, See Iglauer et al., 27, 367Woods, L A. The pharmacology of nalorphine (N-

allylnormorphine), 8, 175Wright, G. Payling. The neurotoxins of Clostridium

botulinum and Clostridium tetani, 7, 413Wright, Peter H. See Mayhew et al., 21, 183

Wurster, R. M. See Griffith et aL, 27, 357

Wurtman, R. J., Pohorecky, L A., and Baliga, B. S.Adrenocortical control of the biosynthesis of epi-

nephrine and proteins in the adrenal medulla, 24,411

-, See Pohorecky and Wurtman, 23, 1

Wuttke, W. See Hoffmeister and Wuttke, 27, 419

Yalow, Rosalyn S. Radioimmunoassay methodology:

application to problems of heterogeneity of peptidehormones, 25, 161

-, Chairman. First Session: Background-Theoret-

ical and Practical, 25, 161-214Yanagita, T. Some methodological problems in assess-

ing dependence-producing properties of drugs in an-

imals, 27, 503

Youdim, M. B. H. See Sandier and Youdim, 24, 331Youngblood, William W. See Kizer et al., 29, 301

Zaimis, Eleanor J. The interruption of neuromusculartransmission and some of its problems, 6, 53

-, See Paton and Zaimis, 4, 219Zbinden, G. Application of basic concepts to research

in toxicology, 30, 605

Zeller, E. A. The role ofamine oxidases in the destruc-

tion of catecholamines, 11, 387-, Summary ofdiscussion and commentary, 18, 141

643

0031-6997/79/3004-0643$02.O0/0PHARMACOLOGICAL REVIEWS

Copyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics

Subject Index

Pharmacological Reviews

Volumes 1-30

1949-1978

Vol. 30, No. 4Printed in USA.

Absorption

of drugs, from subcutaneous connective tissue, 13,441

Acetylcholine

-like substances, effect of, on sensory receptors, 6,

97

local hormone for ciiary movement and the heart,

6, 107

metabolism, 6, 45of nervous tissue, 6, 39

receptors, acetylcholinesterase and, accumulation at

newly formed nerve-muscle synapses, 30, 411related quaternary ammonium compounds and, ex-

citatory and anti-curare properties of, at the

neuromuscular junction, 5, 1transmission and, at chemoreceptors, 6, 79

Acetylcholinesterase, acetylcholine receptors and, ac-cumulation at newly formed nerve-muscle

synapses, 30, 411Acid. See specific name or type of acid

Addiction

analgesics and barbiturates, 2, 355

narcotic (man), experimental analysis of condition-

ing factors in, 27, 533

Adenosine-3’,5’-cycic monophosphate (cyclic AMP)and lipolytic effects of hormones on adipose tissue,

18, 237phosphorylase and, relation to actions of catechol-

amines and other hormones, 12, 265

role in actions of catecholamines, 24, 399

role in responses to catecholamines and other hor-

mones, 18, 145

Adenosine triphosphatase, Na� ,K�

pharmacological, physiological, and biochemical as-pects, 27, 3

role of, in the inotropic action of digitalis, 29, 1873’,5’-Adenylate

gluconeogenesis stimulation from lactate by, in per-

fused rat liver, 18, 181

Adipose tissue. See under Tissue(s)

Adrenal cortex and central nervous system, relation

between, 10, 275Adrenal medulla

adrenocortical control of biosynthesis of epineph-

rime and proteins in, 24, 411

glucose deprivation effects on sympathetic outflowto, 18, 303

mechanism of release of catecholamines from, 18,

471

nervous tissue and, role of L-dopa decaboxylase inthe biosynthesis ofcatecholamines in, 11, 317

secretory cycle in, 24, 385Adrenaline (See also Epinephrine)

metabolism of, 1, 1‘noradrenaline and

biosynthesis of, 11, 350

blockade of the actions of, 11, 443

in blood and urine, 6, 35metabolic products of, in human urine, 11, 416

Adrenergic activation by anticholinesterases, 18, 799

$-Adrenergic binding sites, isolated, potential assay

vehicle for catecholamines, 25, 259

Adrenergic blockade

in cardiovascular disease, 18, 701

pharmacology of, 1, 27

Adrenergic drugs. See under Drug(s)

Adrenergic endings and vesicles, isolated from brain,18,413

Adrenergic function and surgical sympathectomy, 18,

611

Adrenergic innervation of the oviduct, role in the

regulation ofmammalian ovum transport, 29,67

Adrenergic mediators

distribution and metabolism of, 6, 29

nature of, 3, 247Adrenergic modulation of ganglionic transmission,

new possibilities, 18, 743

Adrenergic nerve

function, methyldopa and, 18, 569

stimulation, modification of norepinephrine synthe-

sis during, 24, 203

Adrenergic neuron(s), interactions of drugs with, 18,577

Adrenergic receptorsadrenoceptive sites or, aspects of blockade of inhib-

itory, 11, 462

for epinephrine and norepinephrine, 11, 429, 441

pharmacological characterization of, 18, 503

Adrenergic synapse. See under SynapseAdrenoceptive sites or adrenergic receptors, blockade

of inhibitory, 11, 462Adrenochrome and 1-noradrenaline, action of, on un-

fatigued mammalian muscle, 6, 33

644 SUBJECT INDEX, VOLUMES 1-30

Adrenocortical control

of biosynthesis of epinephrine and proteins in ad-

renal medulla, 24, 411

of epinephrmne synthesis, 23, 1

Adrenocortical steroidsactivity of, chemical and biological factors in, 14,

317

role in infection, immunity, and hypersensitivity,

8, 1

Age-related changes in drug disposition, 30, 445

Aldosterone-renin-angiotensin, measurements of, 25,249

Alkaloids, pyrrolizidine (Senecio), toxic actions of, 22,429

Allergy, drug, 6, 365N-Allylnormorphine (nalorphine), pharmacology of, 8,

175

Amanita phalloides, toxins of, chemistry and toxicol-

ogyof, 11,87Amebiasis, chemotherapy of, 2, 399

Amidine derivatives, structure-activity relationships,14, 37

Amines

biogenic, and catecholamines, methylation reactions

in formation and metabolism of, 18, 95epinephrine-related, metabolic effects of, 8, 485spermidine, spermine, and related amines, 16, 245

See also Aromatic, Hydroxyl-, Plasma pressor, andSympathomimetic amines

Amine mechanisms in cerebral circulation, 28, 275Amine oxidase

amine metabolism and, 4, 415histaminase and, 18, 1163

role of, in the destruction ofcatecholamines, 11, 387Amino acids

neurotoxic, structurally related analogs and, 29,301related to y-aminobutyric acid, pharmacology of, 17,

347-y-Aminobutyric acid, pharmacology of amino acids

related to, 17, 347Amphetamines and caffeine, enhancement of human

performance by, 14, 1

Analeptics, 12, 447

Analgesicsbarbiturates and, addiction to, 2, 355clinical evaluation of morphine and its substitutes

as, 16, 47

Analogues. See Metabolite and Structural analogues

Anemias

hemolytic, drug-induced, 21, 73macrocytic, hematopoietic agents in, 3, 345

Anesthesiaeffects of, on metabolism and cellular functions, 17,

183

general, theories of, 2, 121mechanisms, role of inert gases in, 15, 97

Anesthetics and tranquilizers, membrane actions of,

24, 583

Angiotensin-aldosterone-renin, measurements of, 25, 249

effects on central nervous system, 25, 415pharmacology of, 26, 69

remit-, system, 17, 143Anions

effects of, on excitable cells, 16, 193organic, secretion of, in formation of urine and bile,

11, 109

Antagonisms

antagonists and, 9, 237metabolite, in bacteria, 9, 264

Antagonists

antagonisms and, 9, 237folic acid, in cancer chemotherapy, 14, 915-hydroxytryptamine, 13, 399

opioid, 19, 463sympathomimetic arnines and, actions on skeletal

muscle, 21, 27Anthelmintics, 9,329

effects of, and biochemical and physiological mech-anisms, relationships between, 18, 871

Antibacterial action, mechanisms of, 5, 275

Antibiotic action, mechanisms of, 15, 481

Antibiotics

inhibition of mammalian protein synthesis by, 21,213

nutritional effects of, 5, 381

pharmacology and toxicology of, 2, 1

Antibodies

physiological receptors and, role in cardiovascular

diagnosis, therapy, and research, 25, 215specific, reversal of pharmacological and toxic ef-

fects of cardiac glycosides by, 25, 239use of, to study cell structure and metabolism, 25,

343

Anticancer agents, physiological disposition of, 11, 743

Anticholinesterase drugs. See under Drug(s)Anticholinesterases

action of, on spinal reflexes following intraarterialinjection, 6, 49

adrenergic activation by, 18, 799Anticoagulant drugs. See under Drug(s)

Anticoagulant therapy, 13, 279Antidepressant compounds, imipramine and related,

clinical pharmacology of, 17, 101Antidromic vasodilatation in the paw of the cat, 6, 99Antifertility substances, 11, 135Antihistaminics, atropine, and antispasmodics, kinet-

ins of recovery from inhibition by, 9, 259

Antimitotic agents, new aspects of pharmacology of,

15, 449

Antioxidants and redox substances, influence on signs

of vitamin E deficiency, 9, 1

Antiprostaglandins, specificities and some applicationsof, antibodies to pharmacologically active

molecules, 25, 293

Antispasmodics, antihistaminics, and atropine, kinet-ics of recovery from inhibition by, 9, 259

Antithyroid substances, survey of factors controlling

thyroid function with especial reference to, 7,301

SUBJECT INDEX, VOLUMES 1-30 645

Aromatic amines, biochemical production of ferrihe-

moglobin-forming derivatives from, and

mechanisms of ferrihemoglobin formation,

18, 1091

Arrhythmias, cardiac. See Cardiac arrhythmias

Arsenosobenzenes, biological activity of, in relation totheir structure, 3, 107

Ascorbate and dopamine-,6-hydroxylase, 18, 61Assay, immunological. See Immunological assay

Atropineantihistaminics, antispasmodics, and, kinetics of re-

covery from inhibition by, 9, 259related compounds and, behavioral and electroen-

cephalographic effects of, 18, 965

use and limitations of, for pharmacological studieson autonomic effectors, 7, 467

Auditory system, peripheral. See Peripheral auditory

system

Autonomic drugs. See under Drug(s)Autonomic effectors, use and limitations of atropine

for pharmacological studies on, 7, 467Autonomic ganglia

synaptic mechanisms in, modification by drugs, 18,

839

transmission and block in, 6, 59Autonomic innervation of visceral and cardiovascular

systems in vertebrates, evolution of, 21, 247Autonomic nervous control of reproduction, circula-

tory, and other factors, 24, 657Autonomic neuroeffector transmission and transmit-

ter reactivity in embryonic and fetal hearts,

ontogenetic development of, 29, 3

Bacteria

metabolite antagonisms in, 9, 264

toxins of, pharmacology of, 16, 1

Bacterial pyrogens, 9, 427Barbiturates

analgesics and, addiction to, 2, 355metabolism of, 1, 217morphine, serotonin, and, antibodies to, 25,281

Behavior

control of by consequent drug injections, 27, 301

controlled by scheduled injections of drugs, chaac-teristics of, 27, 307

drug-taking, control of by schedules of reinforce-

ment, 27, 291

electroencephalography and, effects of atropine andrelated compounds on, 18, 965

stimuli associated with drug injections as events

that control, 27, 325Bile and urine, secretion oforganic anions in formation

of, 11, 109

Bioassay procedures for catecholamines, 11, 241

Bioassays and mathematics, 5, 87Biological activity, ionization, and pH, 4, 136

Biosynthesis of prostaglandin, inhibition by drugs, 26,33

Bis(2-haloethyl) amines and suiphides, pharmacology

of, 2, 281

Blockade, adrenergic. See Adrenergic blockade

Blocking ag��nts, ganglionic. See Ganglionic blockingagents

Bloodand tissue changes, induced by norepinephrine-

stimulated mobilization of free fatty acid, 18,241

coagulation and related phenomena, influence of

certain drugs on, 3, 278

urine andadrenaline and noradrenaline in, 6, 35catecholamine assays, spectrophotofluorimetric

observatins on, 11, 296Blood-brain barrier, monoaminergic, localization of

mechanisms, 18, 369

Blood vessels

capsule and, of the spleen, drug action on smoothmuscle of, 25, 373

catecholamines in, effects ofdrugs and physiological

factors in disposition of, 24, 191

Body temperature, actions of monoamines, pyrogens,

and cations on central control of, 26, 289

Brain

adrenergic endings and vesicles isolated from, 18,413

catecholamines in, 11, 483

electrical activity of, effects of drugs upon, 1, 425interaction of drugs with norepinephrine in, 11, 548rat, effects ofdrugs on disposition of H3-norepineph-

rine in, 18, 775

Brain dopamine, possible role of, 18, 769Brain function and dopamine (3-hydroxytyramine),

18, 925Brain-stem reticular formation, drug action on, 14, 175

Caffeine and amphetamines, enhancement of humanperformance by, 14, 1

Calcium

and the relaxant effect of isoproterenol in depolar-

ized rat uterus, 18, 495role of

in the receptor regulation of membrane permea-

bility, 30, 209in release of neurotransmitter substances and hor-

mones, 22, 389-sodium interactions in mnmmRlian smooth muscle,

30, 167Calcium indicators, biological, photoproteins as, 28, 1

Calcium ions, role of, in neural processes, 6, 243

Canceranti-, agents, physiological disposition of, 11, 743chemotherapy, folic acid antagonists in, 14, 91immunotherapy, 25, 325

Cannabis, dose-response relationships to, in human

subjects, 23, 339Cannabis prelude, 23, 263

Capillary permeability, substances which affect, 10,475

Carbon monoxide, 2,324Carbon tetrachloride, hepatotoxicity, 19, 145

646 SUBJECT INDEX, VOLUMES 1-30

cholinesterases and, demonstration of, in the same

section, 18, 353stores, pharmacological depletion of, 18, 541

symposium on, 11, 233-566

Carbonic anhydrase inhibitors, 8, 137Carcinogenesis, chemical, mechanisms of, nature of

proximate carcinogens, and interactions withmacromolecules, 18, 805

Carcinogens

modulating factors and, DNA fragmentation andDNA repair of mammalian cells as indicators

for complex interactions between, 30, 493

proximate, nature of, and interactions with macro-molecules, 18, 805

Cardiac arrhythmias

experimental, and quinidine-like drugs, 4, 43ionic mechanism in heart muscle in relation to the

genesis and the pharmacological control of,30, 5

Cardiac glycosides

action ofcellular basis of, 11, 173on ion movements, 16, 381

metabolic action of, and energy metabolism of fail-

ing heart, 1, 311

reversal of pharmacological and toxic effects of, byspecific antibodies, 25,239

subcellular basis for mechanism of inotropic actionof, 23, 193

Cardiovascular and renal actions of dopamine, poten-tin! clinical applications, 24, 1

Cardiovascular diagnosis, therapy, and research, roleof antibodies and physiological receptors in,25, 215

Cardiovascular disease, adrenergic blockade in, 18, 701Cardiovascular effects of monoamine oxidase inhibi-

tore, 18, 705Cardiovascular and visceral system, evolution of au-

tonomic innervation of, in vertebrates, 21,247

Canes-inhibiting agents, 11, 705Carotid body and sinus, action of drugs on, 7, 119

Carrier transport and its corollaries in pharmacology,concept of, 13, 109

Cat, antidromic vasodilatation in paw of, 6, 99Catechol compounds, fluorimetric estimation of, by

ethylenedismine condensation method, 11,

278

Catechol-O-methyl transferase, pharmacological as-pacts and physiological role, 27, 135

Catecholamine

assays

blood and urine, spectrophotofluorimetric obser-vations on, 11, 296

newer developments, 18, 325

behavioural and electrophysiological effects of, 18,753

bioassay procedures, 11, 241

biosynthesis of, in insects, 18,89central actions of, 11, 565chemical and physical methods for measuring, 11,

252

development and applications of the trihydroxyin-dole method for, 11, 262

-drug interactions in man, 18, 673effects of, on the central nervous system, 11, 494

endogenous, inhibitors of biosynthesis, 18, 599

estimation of, by biological assay, 18, 317

fluorescence microscopy of, methodology, 18, 351formation

development of current concepts of, 11, 307in intact tissues, 11, 358

hypertension and, 18, 667in blood vessels, effects of drugs and physiological

factors in the disposition of, 24, 191

in brain, 11, 483in nervous tissue and the adrenal medulla, role of L-

dopa decarboxylase in biosynthesis of, 11,317

in neuropsychiatric states, 18, 787

in the nervous system, occurrence, distribution, and

physiological role of, 11, 490

influence on heart function and phosphorylase ac-tivity, 18, 197

interactions with enzymes and receptors, steric ef-

fects in, 18, 131

interrelationships with other endocrine systems, 18,

273

isolated $-adrenergic binding sites, a potential assay

vehicle for, 25, 259

mechanisms for termination of the physiologicalactions of, 11, 381

mechanism of release from adrenal medulla, 18, 471metabolism

in patients with pheochromocytoma, 11, 374in vivo and in vitro, 11, 402regulation of, in the sympathetic nervous system,

24, 365

other biogenic amines and, methylation reactions information and metabolism of, 18, 95

other hormones andrelation of adenosine-3’,5’-phosphate and phos-

phorylase to actions of, 12, 265

role of cyclic 3’,5’-AMP in responses to, 18, 145

-producing neural tumors other than pheochromo-cytoma, 18, 659

role, in cold adaptation, 18, 291

role ofadenosine 3’,5’-monophosphate in actions of,24, 399

role of amine oxidases in the destruction of, 11, 387role of monoamine oxidase in storage and metabo-

ham of, 16, 179

-secreting tumors, chemistry and pharmacology of,18, 645

serotonin and, release of, by drugs, 14, 531stimulation of fat mobilization and its metabolic

consequences, 18, 217storage and release of, 11, 361storage particles in the central nervous system, 18,

401

SUBJECT INDEX, VOLUMES 1-30 647

symposium on (second), 18, 1-804

synthesis and degradation, immunological tech-niques applied to study of enzymes regulat-ing, 24, 311

synthesis and metabolism, influence of specific nu-

trients on, 24,349-synthesizing enzymes, characterization and tissue

localization of, 24, 293

turnover, regulation by variation of enzyme levels,24, 225

Cations, monoamines, and pyrogens, actions on central

control of body temperature, 26, 289

Cell(s)action potential and excitation, 10, 165

cell constituents and, effects of hormones on, 12,301

excitable

effects of anions on, 16, 193electrochemical aspects ofphysiological and phar-

macological action in, 10, 59, 165insulin-secreting, drugs producing diabetes through

damage of, 22, 485

intercellular communication, gap junction dynamics

and, 30, 383mammalian, DNA fragmentation and DNA repair

of, indicators for the complex interactionsbetween carcinogens and modulating factors,

30, 493mast, pharmacology and functions of, 7, 267

microbial and mammalian, application to assess-

ment of mutagenicity, 30, 537resting, and its alteration by extrinsic factors, 10,59

Cell constituents and cells, effects of hormones on, 12,301

Cell membrane, hormone-receptor interactions at, 30,393

Cell nucleus, steroid hormone interaction with, 30, 477

Cell preparationsbroken, action of epinephrine and norepinephrine

in, 11, 464

broken and intact, from liver fluke Fasciola hepa-twa, actions of serotonin and epinephrmne on,11,465

Cell protoplasm, contraction of muscle and, models

for study of, 7, 97

Cell structure and metabolism, use of antibodies tostudy, 25, 343

Cell transport, control in mammals by sex hormones,

27, 207Cellular functions and metabolism, effects of anesthe-

sin on, 17, 183

Central nervous system

actions of nicotine on functions of, 14, 137actions of some synthetic tetrahydrocannabinol de-

rivatives, 23, 317adrenal cortex and, relation between, 10, 275angiotensin effects on, 25, 415catecholamine storage particles in, 18, 401

drug-induced alterations of ion distribution at the

cellular level of, 29, 35

effects of catecholamines on, 11, 494

metabolism of epinephrine in, 18, 1201

norepinephrine and epinephrine in, 6, 31regulation of monoamine metabolism in, 24, 371

sites and mechanism of action of morphine and

related drugs in, 2,435

Central neurons containing dopamine, noradrenaline,

and 5-hydroxytryptamine, demonstration

and mapping of, and their reactions to psy-

chopharmaca, 18, 727Central transmission

ganglionic and, 6, 105

sensory and, 6, 85, 95, 103Cephalosporins, 14, 473

Cerebral circulationaction of drugs on, 11, 1

amine mechanisms in, 28, 275Cerebrospinal fluid, actions of substances introduced

into, and the problem of intracranial chemo-

receptors, 13, 71

Chelation as mechanism of pharmacological action, 8,

57

Chemical carcinogenesis. See under Carcinogenesis

Chemical protection and ionizing radiation, in mars-

mals, pharmacological aspects of, 10, 437Chemoreceptors

acetylcholine and transmission at, 6, 79chemical transmission at, 6, 81intracranial, problem of, and the actions of sub-

stances introduced into cerebrospinal fluid,

13, 71

transmission at, 6, 73

Chemotherapeutic agents, dosage schedule of, 4, 85

Chemotherapy

amebiasis, 2, 399

cancer, folic acid antagonists in, 14, 91ifianal infections, 7, 179

leprosy, 10, 1tuberculosis, wider aspects of, 5, 421viral diseases, 15, 407

advances in, 19, 209

influence of dietary, hormonal, and other factors,

8, 199

Chiorpromazine and endocrine function, 19, 251Cholestasis, intrahepatic, induced by drugs and chem-

icals, 28, 207Choline esters as local hormones, 6, 113Cholinergic drugs. See under Drug(s)

Cholinergic systems in non-nervous tissues, 30,65

Cholinesterases

catecholamines and, demonstration of, in the same

section, 18, 353drugs, anti-. See under Drug(s)

hydrophobic areas on active surface of, 22, 355inhibitors, organophosphorus, pharmacology of, 11,

567

localization of specific, in the retina, 6, 47Cholinoreceptors of locomotor muscles, mutual dis-

position of, and changes in their dispositionin the course of evolution, 18, 1051

648 SUBJECT INDEX, VOLUMES 1-30

Chromaffin tissue, 18, 453Chromatid exchange, sister, in vitro and in vivo anal-

ysis of, 30, 501

Chromatograms, running, of tissue extracts, points to

be considered, 11, 249

Chromosomes, eukaryotic. See Eukaryotic chromo-

somes

Ciliary movement and heart, acetylcholine as local

hormone for, 6, 107

Circulation. See Cerebral, Coronary, Peripheral, and

Pulmonary circulation

Clostridium botulinum, and Cl. tetani, neurotoxins of,

7,413

Clostridium tetani� Cl. botulinum and, neurotoxans of,

7,413

Coagulant, anti-, therapy, 13, 279Cocaine injection, concurrent schedules of, in rhesus

monkeys, dose variations under independent

and dependent variable-interval procedures,27, 367

Coenzymes

dopa decarboxylase, 18, 53hydroxylases and, ascorbate and dopamine-/3-

hydroxylase, tetrahydropteridines and phen-ylalanine and tyrosine hydroxylases, 18, 61

Cold adaptation, role of catecholamines in, 18, 291

Complement activation, activities and pharmacologi-cally active products of, 26, 125

COMT. See Catechol-O-methyl transferase

Connective tissue. See wider Tissue

Conversations in pharmacology, 29, 185-247

Copper metabolism, 12, 355Coronary circulation, pharmacology of, 3, 197Corticosteroids, hepatic and extrahepatic regulation

of, 13, 329

Cough, pathophysiology and pharmacology of, 9, 43Curariform drugs. See under Drug(s)

Cyclic nucleotides, radioimmunoassay for, 25, 309

Darmstoff, gut-stimulating compound occurring in the

inte8tinal wall, 6, 117Decarboxylase, dope. See Dope decarboxylase

Denervation, pharmacological, supersensitivity fol-lowing, 13, 17

Deoxyribonucleic acidfragmentation and repair of mammalian cells as

indicators for complex interactions between

carcinogens and modulating factors, 30, 493

in eukaryotic chromosomes, levels of organization

of, 30, 469of eukaryotic cells, effects of incorporation of 5-

halogenated deoxyuridines into, 29,249

Deoxyuridines. 5-Halogenated. See 5-Halogenateddeoxyuridines

Diabetes, drugs producing, through damage of insulinsecreting cells, 22, 485

Diabetes mellitus, oral treatment of, 12,91a,w-Dicarboxylic acids, related substances and, dicho-

linesters of, 8, 265

Dicholinesters of a,w-dicarboxylic acids and related

substances, 8, 265

Dietary interrelationship and mechanism of action ofhepatotoxic agents, 4, 1

Digitalis, role of Na�,K�-ATPase in the inotropic ac-

tion of, 29, 187Digitalis glycosides, radioimmunoassay of, clinical

value, 25, 219

Digoxin tablets, bioavailability of, 25, 229

3,4-Dihydroxymandelic acid in urine, estimation of,

18, 331Dihydroxyphenylalkylamines, epinephrine-related,

pharmacological activity of, 1, 279

Diuretics

mechanism of action and therapeutic use of, 2, 161

mercurial, site and mechanism of action of, 20, 89physiological basis for action of, 13, 517

DNA. See Deoxyribonucleic acidDope decaboxylase

substrates, coenzyme, inhibitors, 18, 53tyrosine hydroxylase and, changes induced by phar-

macological agents, 24, 269

L-Dopa decarboxylasein vitro and in vivo, studies on inhibition of, 11, 330role in biosynthesis of catecholamines in nervous

tissue and the adrenal medulla, 11, 317

Dopamine

brain, possible role of, 18, 769cardiovascular and renal actions of, potential clinical

applications, 24, 1

detection and assay of, 11, 3006-hydroxy-. See 6-Hydroxydopamine

noradrenaline, 5-hydroxytryptamine and, demon-stration and mapping of central neurons con-

taming, and their reactions to psychophar-maca, 18, 727

norepinephrine and, in noradrenergic axons, precur-

sor product relationship study by mass frag-

mentography and radiochemistry, 24, 167Dopamine-$-hydroxylase, 17, 71

ascorbate and, 18, 61regulation of its synthesis and release from nerve

terminals, 24, 233

serum, 30, 133

Dopamine-f3-hydroxylation stage, norepinephrmne bio-synthesis inhibition at, 18, 77

Dopamine (3-hydroxytyramine) and brain function,

18, 925

Drug(s)absorption of, from subcutaneous connective tissue,

13, 441

abuse, human, behavioral factors in, 27,499action

membrane lipids and, 19,59molecular basis of, 19, 107on brain-stem reticular formation, 14, 175on carotid body and sinus, 7, 119

on cerebral circulation, 11, 1on intestinal motility, 6, 159

on myocardial contractility, physical factors in

analysis of, 15, 531

SUBJECT INDEX, VOLUMES 1-30 649

-taking behavior, control by schedules of reinforce-

on smooth muscle of the capsule and blood vesselsof the spleen, 25, 373

on spermatogenesis, biochemical aspects of, 19,21

uncoupling of oxidative phosphorylation as a

mechanism of, 7, 335

addiction (human), experimental analysis of condi-

tioning factors in, 27, 533

adrenergic, activity of, molecular geometry and, 26,323

allergy, 6, 365antagonism

nonequiibrium, 9, 246

pA1 and, 9, 242theories of, 9, 211

anticholinesterase, 1, 166

anticoagulant, oral, determinants of the response to,

in man, 22, 35

antischistosomal and other, protection from muta-genic effects of, 30, 547

antituberculosis, 15, 169assessment of dependence producing properties in

annuals, methodological problems in, 27, 503

autonomic, actions of, on phosphorylase activity andfunction, 17, 27

catecholamine-, interactions in man, 18, 673chemicals and, intrahepatic cholestasis induced by,

28, 207cholinergic, actions on motor nerve terminals, 29,

221

consequent injections, control of behavior by, 27,

301

curariform, synthetic, basic aspects of pharmacology

of, 3, 412depressant, action on spinal cord, 1, 243

disposition, age-related changes in, 30, 445

disturbances of liver porphyrin metabolism caused

by, 19, 523effects, and concurrent performances, 27, 385effects of

and physiological factors in the disposition ofcatecholamines in blood vessels, 24, 191

on electrical activity of the brain, 1, 425

on enzyme systems, 8, 89on the disposition of H3-norepinephrine in rat

brain, 18, 775on the foetus, 12, 37on the mobilization of free fatty acid, 18, 243

on vertebrate mechanoreceptors, 16, 341

experimental self-administration (human), method-

ology and application to study of sedativeabuse, 27, 523

heart impulses affected by, 15, 277

hormone and, action on adipose tissue, biochemical

aspects of, 25, 67

hypertension treatment, 5, 135

immunological assay of, 29, 103

immunosuppressive, 22, 189

-induced alterations of ion distribution at the cellu-lar level of the central nervous system, 29,35

-induced hemolytic anemia, 21, 73-induced lysosomal lipidosis, biochemical interpre-

tations, 30, 593influence of, on blood coagulation and related phe-

nomena, 3, 278influence of previous experience, expectation, and

setting on maihuana-induced “high”, 23,359

injection

complex schedules of, 27, 341

negative reinforcers, 27, 437

schedules of termination of, 27, 395

stimuli associated with, as events that control

behavior, 27, 325interactions,

affmity, intrinsic activity, and, 9, 218with adrenergic neurons, 18, 577

with norepinephrine in the brain, 11, 548intermediary metabolism of thyroid tissue and ac-

tion of, 15, 43intraspecies differences in frequency of genes di-

rectly affecting disposition of, individual fac-tor in drug response, 30, 555

metabolism, toxicological implications of, 30, 457-metabolizing enzyme system, role of nutrition in,

26, 171

modification of norepinephrine synthesis in intacttissue by, 24, 203

motion sickness, use in, 18, 895non-opiate psychotropic, tolerance to and depen-

dence on, 23, 135oral intake of, schedule-induced polydipsia and, 27,

447, 489passage of, across body membranes, 14, 501

plasma proteins and, interactions of, 1, 102

porphyrin metabolism and, 6, 133

preference in rhesus monkeys, pharmacological andenvironmental variables affecting, 27, 343

producing diabetes through damage of insulin se-creting cells, 22, 485

prostaglandin biosynthesis inhibition by, 26,33protein conjugates, principles and methods for prep-

aration of, for immunological studies, 25, 271psychotomimetic, biochemical aspects ofthe actions

of, 17, 1

psychotropic, as negative reinforcers, 27, 419quinidine-like, experimental cardiac arrhythmias

and, 4, 43reinforcers in monkey and man, 27, 511

release of serotonin and catecholamines by, 14, 531response, individual factor in, 30, 555

response of liver to, morphometric analysis in as-sessment of, 30, 429

scheduled injections of, characteristics of behavior

controlled by, 27, 307

sleep and, 20, 273synaptic mechanisms in autonornic ganglia, modifi-

cation by, 18, 839systemic, inhibition ofkeratinizing structures by, 15,

653

SUBJECT INDEX, VOLUMES 1-30

electrolytes, plasma proteins and, role in experimen-

650

Drugs-continued

ment, 27, 291

techniques and results of studies of self-adininistra-

tion of, use in other areas of psychobiology,

27, 545

Edema, lung, physiology and pharmacology of, 8, 389Electrical activity of brain, effects of drugs upon, 1,

425

ncephalography and behavior, effects of atro-pine and related compounds on, 18, 965

Electrolytesfluids, plasma proteins and, role in experimental

traumatic shock and hemorrhage, 6, 489

smooth muscle contraction and, 16, 85

Electron microscopy of sympathetic tissues, 18, 387Endocrine function and chlorpromazine, 19,251Endocrine systems, interrelationships of catechol-

amines with other, 18, 273Endoperoxides, prostaglandin. See under Prostaglan-

din(s)

Enzyme(s)catecholamine-synthesizing, characterization and

tissue localization of, 24, 293

involved in synthesis of norepinephrine, effect ofneuronal activity and nerve growth factor on,24, 255

levels, regulation of catecholamine turnover by var-iations of, 24, 225

microsomal, pharmacological implications in induc-

tion of, 19, 317receptors and, steric effects in catecholamine inter-

actions with, 18, 131regulating catecholamine synthesis and degradation,

immunological techniques applied to study

of, 24, 311

transport of, in viva, by axons of sympathetic neu-rons, 24, 245

Enzyme systems

drug-metabolizing, role of nutrition in, 26, 171

effects of drugs on, 8,89Enzyme treatment, pre- and postnatal pathology, and

unresolved issues in five lysosomal disorders,

30, 593Enzymic studies on the mechanism of double hydrox-

ylation, 18, 71

Epinephrine

effects in perfused rat heart, kinetic studies, 18,205excretion and metabolism of, 11, 409gluconeogenesis stimulation from lactate by, in per-

fused rat liver, 18, 181glycolysis activation in frog sartorius muscle by, 18,

189

norepinephrine and

action of, in broken cell preparations, 11, 464

adrenergic receptors for, 11, 429,441

distribution and action, 6, 15estimation of concentrations of in human plasma,

by the trihydroxyindole method, 11, 273in the central nervous system, 6, 31

in tissues, technique involving solvent extractionfor estimation of, 11, 276

metabolism of, 6, 233-methoxy-4-hydroxy-D-mandelic acid, a urinary

metabolite, formation of, 11, 394

proteins and, in the adrenal medulla, adrenocorticalcontrol of the biosynthesis of, 24, 411

related amines and, metabolic effects of, 8, 485related dihydroxyphenylalkylamines and, pharma-

cological activity of, 1, 279relation of biochemical effects of, to its muscular

effects, 11, 469serotonin and, actions of, on intact and broken cell

preparations from the liver fluke, Fasciola

hepatica, 11,465synthesis, adrenocortical control of, 23, 1

Erythropoietin pharmacology, biogenesis, and controlof production, 24, 459

Ethanol

metabolism, 4, 107and its metabolic effects, 24,67

positive reinforcer, function of schedule-inducedpolydipsia in, 27, 465

schedule-induced physical dependence on, 27, 449

Ethylenediamine condensation method, fluorimetric

estimation ofcatechol compounds by, 11, 278

Ethylenediamine method ofWeil-Malherbe and Bone,

suitability of and modifications for quantitat-

ing plasma presser amines, 11, 289

Eukaryotic cells, effects of incorporation of 5-halo-genated deoxyuridines into the DNA of, 29,249

Eukar.yotic chromosomes, DNA in, levels of organi-zation of, 30, 469

Excitation-contraction coupling in skeletal muscle, 17,165

Excitation phenomena, tetrodotoxin and saxitoxin, sig-nificance in the study of excitation phenom-

ens, 18, 997Excretion

metabolism and, of epinephrine, 11, 409renal tubular, of organic bases, 12, 1

Expectorants and respiratory tract fluid, 6, 521

Fasciola hepatica, actions of serotonin and epineph-rime on intact and broken cell preparations

from 11, 465Fat mobilization, and its metabolic consequences,

catecholamine stimulation of, 18, 217Fat transport and heparin (clearing factor lipase), 12,

241

Fatty acid, free. See Free fatty acid

Ferrihemoglobin formation, mechanisms of, the bio-chemical production of ferrihemoglobin-

forming derivatives from aromatic amines,

18, 1091

Fertility, anti-, substances, 11, 135

Filanal infections, chemotherapy of, 7, 279

Fluid(s)

SUBJECT INDEX, VOLUMES 1-30 651

tel traumatic shock and hemorrhage, 6, 489

respiratory tract, and expectorants, 6, 521

Fluorescence and its measurement, 11, 256

Fluorescense microscopy of catecholamines, method-ology, 18, 351

Foetus, effects of drugs on, 12, 37

Folic acid antagonists in cancer chemotherapy, 14, 91

Food and heroin, effects of naloxone and methodone

on choice between, 27, 357

Free fatty acidblood and tissue changes induced by norepineph-

rime-stimulated mobilization of, 18, 241

effect of drugs on mobilization of, 18, 243

Frog sartorius muscle, glycolysis activation in, by epi-

nephrine, 18, 189

Ganglia. See Autoziomic and Sympathetic ganglia

Ganglionic blocking agents, 2, 61Ganglionic synapse. See under SynapseGanglionic transmission

adrenergic modulation of, new possibilities, 18, 743

central and, 6, 105

Gap junction dynamics and intercellular j�ommunica-tion, 30, 393

Gas, inert See Inert gas

Gastric secretion, inhibition of, 3, 59

Gastrointestinal microorganisms, metabolism of for-eign compounds by, 25, 451

Genes directly affecting drug disposition, intraspeciesdifferences in frequency of, 30, 555

Glucagon, gluconeogenesis stimulation from lactateby, in perfused rat liver, 18, 181

Gluconeogenesis stimulation from lactate by epineph-rime, glucagon, and cyclic 3’,5’-adenylate in

perfused rat liver, 18, 181Glucose deprivation, effects on sympathetic outflow to

adrenal medulla and adipose tissue, 18, 303

Glycolysis, activation of, in frog sartorius muscle byepinephrine, 18, 189

Glycoside(s). See Cardiac and Digitalis glycoside(s)Gonadotropin-steroid interrelationships, 25, 189

Growth hormone. See under Hormone(s)Gut-stimulating compound, Darmstoff, occurring in

intestinal wall, 6, 117

Hallucinogens, pharmacology of, 24, 315-Halogenated deoxyuridines, effects of incorporation

of, into the DNA of eukaryotic cells, 29, 249

Halogenation, pharmacophoric effect, mechanisms of,

15, 673

Heart

ciliary movement and, acetylcholine as local hor-mone for, 6, 107

drug action on myocardial contractility, physicalfactors in analysis of, 15, 531

drug effects on generation and conduction of im-pulses, 15, 277

embryonic and fetal, ontogenetic development of

autonomic neuroeffector transmission andtransmitter reactivity in, 29, 3

failing, energy metabolism of, and metabolic action

of cardiac glycosides, 1, 311

failure, congestive, sympathetic activity and neuro-transmitter depletion in, 18, 685

muscle. See under Muscle

myocardial contractility, influence of interval be-

tween beats on, 15,601parasympathetic control of, 25, 119phosphorylase activity and, catecholamine influence

on function of, 18, 197

ratisolated, effect of sympathomimetic amines on

phosphorylase activity of, 11, 466

perfused, kinetic studies of epinephrine effects,18, 205

Heavy metals. See Metals

Hematopoietic agents in macrocytic anemias, 3, 345

Hemorrhage and experimental traumatic shock, role

offluids, electrolytes, and plasma proteins in,6,489

Heparin and fat transport, 12, 241

Hepatic and extrahepatic regulation of corticosteroids,

13, 329

Hepatotoxic agents, mechanism of action and dietary

interrelationship, 4, 1Hepatotoxicity of carbon tetrachloride, 19, 145

Herbicides, toxicology of, 14, 225Heroin and food, naloxone and methadone effects on

choice between, 27, 357Histamine

histidine, and related imidazoles, metabolic studieson, 6, 299

place of, in neurohumoral transmission, 6, 119release by compounds of simple chemical structure,

9, 269Histaminase and related amine oxidases, 18,1163Histidine, histamine, and related imidazoles, metabolic

studies on, 6, 299Histochemistry, a review, 7,83

Homovanilhic acid, measurement of, 18, 343Hormone(s)

catecholamines and, relation of adenosine-3’,5’-phosphate and phosphorylase to actions of,

12, 265

cyclic 3’,5’-AMP and the lipolytic effects of, onadipose tissue, 18, 237

drug and, action on adipose tissue, biochemical as-pects of, 25, 67

effects of, on cells and cell constituents, 12, 301

growth, and tissue receptors, application of radiore-ceptor assay to, 25, 179

localacetylcholine for ciliary movement and the heart,

6, 107choline esters as, 6, 113

neurohypophysial, 13, 225neurotransmitter substances and, role of calcium in

the release of, 22, 389peptide

and their analogues, distribution, clearance from

652 SUBJECT INDEX, VOLUMES 1-30

Hormone(s)-continuedcirculation, and inactivation in vivo, 30, 247

radioimmunoassay methodology applied to het-

erogeneity of, 25, 161-receptor interactions at the cell membrane, 30, 393role of cyclic 3’,5’-AMP in responses to, 18, 145

sex, control of, cell and tissue transport in mammals,27, 207

steroid

biochemistry of, recent trends in, 5, 285

interaction of with the nucleus, 30, 477tumor growth regulation by, 9,367

Human performance, enhancement of, by caffeine andamphetamines, 14, 1

Human plasma. See under Plasma

Hunger and thirst, physiological and pharmacological

aspects of control of, 13, 1Hydrophobic areas on the active surface of cholines-

terases, 22, 355

Hydroxamic acids, and hydroxyl amines, biochemicalformation and pharmacological, toxicological,

and pathological properties of, 25, 16-Hydroxydopamine, pharmacological actions of, 26,

199

Hydroxylamines and hydroxamic acids, biochemicalformation and pharmacological, toxicological,

and pathological properties of, 25, 1Hydroxylases and coenzymes, ascorbate and dopa-

mine-f3-hydroxylase, tetrahydropteridinesand phenylaline and tyrosine hydroxylases,18, 61

dopamine-fl-. See Dopamine-fl-hydroxylase

tyrosine. See Tyrosine hydroxylase

Hydroxylation, double, enzymic studies on mechanism

of, 18, 71

4-Hydoxy-3-methoxymandelic acid, measurement of,

18, 343

3-Hydroxytyramine (dopamine) and brain function,18, 925

5-Hydroxytryptamine

antagonists, 13, 399dopamine, noradrenaline, and, demonstration and

mapping of central neurons containing, and

their reactions to psychopharmaca, 18, 727

Hypersensitivity, infection, and immunity, role of ad-renocortical steroids in, 8, 1

Hypertensioncatecholamines and, 18,667drug treatment of, 5, 135

Hypertensin and renin, pharmacology of, 8, 25Hypoglycin and hypoglycin-like compounds, 21, 105

Imidazoles, histadine- and histamine-related mets-bohc studies, 6, 299

Imipramine and related antidepressant compounds,clinical pharmacology of, 17, 101

Immune response

clinical suppression of, 15, 365

manipulation of, 25, 319Immunity, infection, and hypersensitivity, role of ad-

renocortical steroids in, 8, 1

Immunological assay of drugs, 29, 103Immunological techniques, application to study of en-

zymes regulating catecholamine synthesisand degradation, 24, 311

Immunopharmacology, symposium on, 25, 157-363

Immunosuppressive drugs. See under Drug(s)

Immunosympathectomy, 18, 619

Immunotherapy of cancer, 25, 325Impulses, heart, drug effect on, 15, 277

Indicators, biological calcium, photoproteins as, 28, 1Indolealkylamines, pharmacology of, 6, 425

Indole derivatives of pineal and related neural andretinal tissues, 17, 321

Inert gas

exchange of, at lungs and tissues, theory and appli-

cations of, 3, 1role in anesthesia mechanisms, 15, 97

Infection, immunity, and hypersensitivity, role of ad-renocortical steroids in, 8, 1

Inflammation, mediation of increased vascular perme-

ability in, 14, 251

Inhibition

by antihistaminics, atropine, and antispasmodics,

kinetics of recovery from, 9, 259

central and peripheral, pharmacology of, 15, 333

L-dOpa decarboxylase in vitro and in vivo, studies

on, 11, 330keratinizing structures by systemic drugs, 15, 653

mammalian protein synthesis, by antibiotics, 21, 213norepinephrine biosynthesis at dopamine-$-hydrox-

ylation stage, 18, 77of protein synthesis by puromycin, 16, 223

Inhibitor(s)carbonic anhydrase, 8, 137

dopa decarboxylase, 18, 53monoamine oxidase, cardiovascular effects or, 18,

705

organophosphorus cholinesterase, pharmacology of,

11, 567

Innervationadrenergic. See Adrenergic innervation

autonomic. See Autonomic innervationInotropic action

of cardiac glycosides, subcellular basis for mecha-

nism of, 23, 193of digitalis, role of Na�,K�-ATPase in, 29, 187

Insects, catecholamine biosynthesis in, 18, 89Insulin

circulating, in animals and man, application of ra-

dioreceptor assay to, 25, 179-secreting cells, drugs producing diabetes through

damage of, 22, 485secretion, regulation of, 21, 183

Intestine

Darmstoff, a gut-stimulating compound occurring in

wall of, 6, 117intrinsic reflexes of, pharmacological analysis of, 16,

301

motility of, action of drugs upon, 6, 159

SUBJECT INDEX, VOLUMES 1-30 653

Intraocular pressure, physiological and pharmacolog-ical influences upon, 7, 143

Invertebrates, poikilothermic vertebrates and, phar-macology of, 14, 281

Iodine metabolism in man, quantitative aspects of, 4,

284

Ion distribution, drug-induced alterations of, at thecellular level of the central nervous system,

29, 35Ion movements

action of cardiac glycosides on, 16, 381

in junctional transmission, 19, 289

Ionic mechanisms in heart muscle in relation to the

genesis and pharmacological control of car-disc arrhythmias, 30,5

Ionization, pH, and biological activity, 4, 136Ionizing radiation. See under Radiation

Ironplasma, and transport ofiron in the organism, 4, 371transport of, in the organism, plasma iron and, 4,

371

Isoproterenol, calcium and the relaxant effect of, in

depolarized rat uterus, 18, 495

Junctional transmission, ion movements in, 19, 289

Keratinizing structures, inhibition of, by systemicdrugs, 15, 653

Lactate, gluconeogenesis stimulation from, by epi-

nephrine, glucagon, and cyclic 3’,S’-adenylate

in perfused rat liver, 18, 181

Leprosy, chemotherapy of, 10, 1Lipase clearing factor (heparin), and fat transport, 12,

241

Lipidsmembrane, drug action and, 19, 59prostaglandins, a family of biologically active, 20, 1

Lipidosis, lysosomal, drug-induced, biochemical inter-

pretations, 30, 593

Lipid-soluble acids, naturally occurring, of pharmaco-logical interest, 10, 407

Lithium ion, biology and pharmacology of, 9, 17Liver porphyrin metabolism, disturbances of, caused

by drugs, 19, 523Liver

rat, perfused, gluconeogenesis stimulation from lac-tate by epinephrmne, glucagon, and 3’,5’-ade-

nylate in, 18, 181

response to drugs, morphometric analysis in assess-

ment of, 30, 429

Liver fluke, actions of serotonin and epinephrine onintact and broken cell preparations from, 11,

465

Lungs and tissues, exchange of inert gas at, theory and

applications of, 3, 1Lung edema, physiology and pharmacology of, 8, 389

Lysosomal disorders, pre- and postnatal pathology,enzyme treatment and unresolved issues infive, 30, 565

Lysosomal lipidosis, drug-induced, biochemical inter-pretations, 30, 593

Macrocytic anemias. See under Anemia(s)Macromolecules, interactions with proximate carcin-

ogens, 18, 805

Magnesium, excess, 29, 273Mammals

accessory reproductive organs in, control of cell and

tissue transport by sex hormones, 27, 207

ionizing radiation and chemical protection in, phar-

macological aspects, 10,437

ovum transport in, role of s�renergic innervation ofoviduct in regulation of, 29, 67

protein synthesis inhibition in, by antibiotics, 21,

213Mammalian cells. See under Cell(s)

Mammalian muscle. See under Muscle

Mammalian origin, non-, active polypeptides of, 28,127

Manactions of various marihuana derivatives in, 23,349animals and, application of radioreceptor assay to

circulating insulin, growth hormone, andtheir tissue receptors in, 25, 179

catecholamine-drug interactions in, 18, 673

catecholamine metabolism in patients with pheo-chromocytoma, 11, 374

determinants of response to oral anticoagulants in,22, 35

dose-response relationships to cannabis in, 23, 349

drug abuse, behavior factors in, 27, 499

experimental drug self-administration, methodologyand application to study of sedative abuse,

27, 523iodine metabolism in, quantitative aspects of, 4, 284

metabolism and disposition of �-tetrahydrocanna-

binol in, 23, 371monkey and, drugs as reinforcers in, 27, 511narcotic addiction, experimental analysis of condi-

tioning factors in, 27, 533See also entries beginning “Human”

Marihuana

chemistry of, 23, 265

clinical pharmacology of, 23, 337derivatives, actions of, in man, 23, 349

general and behavioral pharmacology of, 23, 285-induced “high”, influence of expectation, setting,

and previous drug experience, 23,359its surrogates and (symposium), 23, 263-380

toxicology of, 23, 279Mast cells. See under Cell(s)Mathematics and bioassays, 5, 87Mechanoreceptors, vertebrate, effects of drugs on, 16,

341

Medullary particles, 18, 433

Melanotropic agents, biochemistry of, 19, 1Membrane(s)

actions of anesthetics and tranquilizers, 24, 583body, passage of drugs across, 14, 501

654 SUBJECT INDEX, VOLUMES 1-30

Membrane(s)-continued

lipids. See under Lipid(s)permeability, role of calcium in the receptor regu-

lation of, 30, 209

Metabolic products ofadrenaline and noradrenaline inhuman urine, 11, 416

Metabolismacetylcholine, 6,45

of nervous tissue, 6, 39adrenaline, 1, 1amine, amine oxidase and, 4, 415barbiturates, 1, 217

catecholamine

in patients with pheochromocytoma, 11, 374in vivo and in vitro, 11, 402

regulation of, in the sympathetic nervous system,24, 365

cell structure and, use ofantibodies to study, 25, 343cellular functions and, effects of anesthesia on, 17,

183

copper, 12, 355

disposition and, of �9-tetrahydrocannabinol in man,

23, 371distribution and, of adrenergic mediators, 6, 29

drug, toxicological implications of, 30, 457energy, of failing heart, and metabolic action of

cardiac glycosides, 1, 311

epinephrine and norepinephrmne, 6, 23

epinephrine and related amines, 8, 485ethanol and its metabolic effects, 24,67ethyl alcohol, 4, 107excretion and, of epinephrmne, 11, 409foreign compounds by gastrointestinal microorgan-

isms, 25, 451formation and, ofcatecholamines and other biogenic

amines, methylation reactons in, 18, 95histidine, histamine, and related imidazoles, 6, 299

intermediary, of thyroid tissue, and drug action, 15,43

iodine, quantitative aspects of, in man, 4, 284liver porphyrin, disturbances of, caused by drugs,

19, 523monoamine, regulation of, in the central nervous

system, 24, 371mucopolysaccharides of connective tissue, 7, 1

norepinephrine in the central nervous system, 18,1201

porphyrin, drugs and, 6, 133

storage and, of catecholamines, role of monoamine

oxidase in, 16, 179sympathetic regulation of, 19, 367synthesis and, of catecholamines, influence of spa-

cific nutrients on, 24, 349

toxicity and, of methanol, 7, 399

vitamin A, 19,559Metabolite analogues, biosynthetic incorporation of,

10,359Metabolite antagonisms in bacteria, 9,264Metals, heavy, general pharmacology of, 13, 185

Metanephrine in urine, estimation of, 18, 331

Metaraminol, norepinephrmne depletion by, 18, 561

Methadone and naloxone, effects on choice betweenfood and heroin, 27, 357

Methanol, metabolism and toxicity of, 7, 399

Methemoglobin-producing compounds, methemoglo-

binemia and, 3, 144

Methemoglobinemia, and methemoglobin-producing

compounds, 3, 144

Methonium compounds, 4, 2193-Methoxy-4-hydroxy-D-mandelic acid, a urinary me-

tabolite of norepinephrine and epinephrine,

formation of, 11, 394

Methylation reactions, formation and metabolism ofcatecholamines and other biogenic amines,

18, 95Methyldopa and adrenergic nerve function, 18, 569

Microbial cells. See under Cells(s)Molecular basis of drug action, 19, 107Molecular geometry and adrenergic drug activity, 26,

323

Molecular nature of pharmacological receptors, ap-proaches to, 21, 131

Molecular parameters of olfactory response, 22, 1Molecules, pharmacologically active, antibodies to,

specificities and some applications of anti-

prostaglandins, 25, 293

Monkey(s)and man, drugs as reinforcers in, 27, 511rhesus

concurrent schedules of cocaine injection in, dosevariations under independent and non-de-pendent variable-interval procedures, 27, 367

morphine-dependent, termination of a schedule

complex associated with intravenous injec-tions of nalorphine in, 27, 407

naloxone as negative reinforcer in, effects of dose,

schedule, and narcotic regimen, 27, 397pharmacological and environmental variables af-

fecting drug preference in, 27, 343

Monoamine metabolism, regulation of, in the centralnervous system, 24, 371

Monoamines, pyrogens, and cations, actions on centralcontrol of body temperature, 26, 289

Monoamine oxidase(s), 18, 115inhibitors, 18, 121

cardiovascular effects of, 18, 705

multiple forms of, functional significance, 24, 331

role in norepinephrine depletion by reserpine,metaraminol, and related agents, 18, 561

role, in storage and metabolism of catechola.mines,

16, 179Monofluoroacetic acid and related compounds, 1, 383Morphine

and its substitutes as analgesics, clinical evaluation

of, 16, 47and its surrogates, pharmacologic implications of

the fate of, 12, 383barbiturates, serotonin, and, antibodies to, 25, 281

-dependent rhesus monkeys, termination ofa sched-ule complex associated with intravenous in-

SUBJECT INDEX, VOLUMES 1-30 655

Na�,K�-ATPase, role of, in the inotropic action of

jections of nalorphine in, 27, 407

related drugs and, sites and mechanism of action in

the central nervous system 2,435Motion sickness, 7, 33

drugs used in, 18, 895

Motor endplate and ganglionic synapse, transmissionat, 6, 71

Motor nerve terminals. See under Nerve terminals

Mucopolysaccharides ofconnective tissue, metabolism

of, 7, 1Muscarine, muscarone, and related compounds, chem-

istry and pharmacology of, 13, 465

Muscarone, muscarmne, and related compounds, chem-istry and pharmacology of, 13, 465

Muscle

contraction of, and cell protoplasm, models for studyof, 7, 97

heart, ionic mechanisms in, in relation to the genesis

and the pharmacological control of cardiacarrhythmias, 30,5

locomotor, mutual disposition of cholinoreceptors

of, and changes in their disposition in thecourse of evolution, 18, 1051

mammalian

smooth, sodium-calcium interactions in, 30, 167unfatigued, action of l-noradrenaline and adre-

nochrome on, 6, 33

nerve and, actions of snake venoms on, pharmacol-

ogy of phospholipase A and polypeptide tox-ins, 17, 393

-nerve synapses, acetylcholine receptors and acetyl-

cholinesterase accumulation at newlyformed, 30, 411

sartorius, frog, glycolysis activation in, by epineph-rime, 18, 189

skeletalexcitation-contraction coupling in, 17, 265

phosphorylase activation, 18, 163

sympathomimetic amines and their antagonists,actions on, 21, 27

smoothcontraction, electrolytes and, 16, 85of capsule and blood vessels of the spleen, drug

action on, 26, 373vascular, pharmacology of, 7, 183

pharmacology of normal and hypertensive yes-

sels, 22,249structure, pathology, biochemistry, and bio-

physics, 20, 197

Mutagenic effects ofantischistosomal and other drugs,protection from, 30, 547

Mutagenicity, application of microbial and manuna-

han cells to assessment of, 30, 537

Mutagens, 6, 345Myocardial contractility

drug action on, physical factors in analysis of, 15,531

influence of interval between beats on, 15,601

digitalis, 29, 187Nalorphine

in morphine-dependent rhesus monkeys, termina-

tion of a schedule complex associated with

intravenous injections of, 27, 407pharmacology of, 8, 175

Naloxonemethadone and, effects on choice between food and

heroin, 27, 357

negative reinforcer in rhesus monkeys, effects ofdose, schedule, and narcotic regimen, 27, 397

Narcotic ingestion, schedule-induced, 27, 475Nerve(s)

muscle and, actions of snake venorns on, pharma-

cology of phospholipase A and polypeptidetoxins, 17, 393

-muscle synapses, acetylcholine receptors and ace-tylcholinesterase accumulation at newly

formed, 30, 411“pharmacological denervation,” supersensitivity fol-

lowing, 13, 17

See also Adrenergic, Peripheral, Purinergic, andSympathetic nerve

Nerve growth factor, neuronal activity and, effect on

enzymes involved in the synthesis of norepi-nephrine, 24, 255

Nerve mediators, adrenergic. See Adrenergic media-

torsNerve terminals

motor, actions of cholinergic drugs on, 29, 221regulation ofdopamine-fl-hydroxylase synthesis and

release from, 24, 233

Nervous, non-, tissues, cholinergic systems in, 30, 65

Nervous system

catecholamines in, occurrence, distribution, andphysiological role, 11,490

See also Autonomic, Central, or Sympathetic ner-vous system

Nervous tissue. See under TissueNeural processes, role of calcium ions in, 6, 243

Neural tissues. See under Tissue(s)Neurohumoral transmission

beginnings and prospects of, 6, 7place of histamine in, 6, 119

symposium on, 6, 3-132

Neurohypophysial hormones. See under Hormone(s)Neuromuscular junction

excitatory and anti-curare properties of acetylcho-line and related quaternary ammonium corn-pounds at, 5, 1

pharmacology of, 2, 96

Neuromuscular transmission, interruption of, andsome of its problems, 6, 53

Neuron(s). See Adrenergic, Central, and Sympatheticneurons

Neurons! activity and nerve growth factor, effectonenzymes involved in the synthesis of norepi-nephrine, 24, 255

Neuropharmacology of peripheral nerve, 4, 168

Neuropsychiatric states, catecholamines in, 18, 787

SUBJECT INDEX, VOLUMES 1-30

Neurotoxins of Clostridium botulinum and Cl. tetani,

7, 413

Neurotransmitter depletion and sympathetic activity,

in congestive heart failure, 18, 685

Neurotransmitter substances and hormones, role of

calcium in the release of, 22, 389

Nicotine, actions of, on central nervous system func-tions, 14, 137

Noradrenalineadrenaline and

biosynthesis of, 11, 350

blockade of the actions of, 11, 443

in blood and urine, 6, 35metabolic products of, in human urine, 11,-416

dopamine, 5-hydroxytryptamine and, demonstra-tion and mapping of central neurons contain-

ing, and their reactions to psychopharmaca,18, 727

subcellular localisation of, in sympathetic neurons,24, 435

. twenty years of, 18, 29l-Noradrenaline and adrenochrome, action of, on un-

fatigued mammalian muscle, 6,33Noradrenergic axons, dopamine and norepinephrmne

in, precursor product relationship study by

mass fragmentography and radiochemistry,

24, 167Norepinephrine

biosynthesis, inhibition at dopamine-$-hydroxyl-ation stage, 18, 77

comparison of the effect of neuronal activity and

nerve growth factor on enzymes in synthesis

of, 24, 255

depletion by reserpine, metaraminol, and relatedagents, role of monoamine oxidase, 18, 561

dopamine and, in noradrenergic axons, precursor

product relationship study by mass fragmen-

tography and radiochemistry, 24, 167epinephrmne and

action of, in broken cell preparations, 11, 464

adrenergic receptors for, 11, 429, 441

distribution and action, 8, 15estimation of concentrations of in human plasma,

by the trihydroxyindole method, 11, 273in the central nervous system, 6, 31

in tissues, technique involving solvent extractionfor estimation of, 11, 276

metabolism of, 6, 233-methoxy-4-hydroxy-D-mandelic acid, a urinary

metabolite of, formation of, 11, 394H3-, effects of drugs on disposition of, in rat brain,

18, 775interaction of drugs with, in the brain, 11, 548

mechanism of uptake of, 18, 525metabolism of, in the central nervous system, 18,

1201

other amines and, biochemical aspects of release of,from sympathetic nerve endings, 18, 513

-stimulated mobilization offree fatty acid, blood andtissue changes induced by, 18, 241

storage of, in sympathetic nerves, 18, 439synthesis in intact tissue, modification by drugs and

during short-term adrenergic nerve stimula-

tion, 24, 203

Normetanephrine in urine, estimation of, 18, 331

Nucleotides, cyclic. See Cyclic nucleotides

Nutrients, influence on catecholamine synthesis and

metabolism, 24, 349

Nutritioneffects of antibiotics on, 5, 381

role of, in drug-metabolizing enzyme system, 26, 171

Olfactory response, molecular parameters of, 22, 1Olfactory system, function of, 15, 1

Ontogenesis, innervation of the heart and, 29, 3Opioid antagonists, 19,463Organs and systems, exchanges of potassium related

to, 3, 42

Organic, anions. See under Anion(s)Organic bases, renal tubular excretion of, 12, 1

Organophosphorus cholinesterase inhibitors. See un-

der Inhibitor(s)

Oviduct, adrenergic innervation of, role in the regula-tion of mammalian ovum transport, 29, 67

Ovum transport, mammalian, role of adrenergic inner-vation of the oviduct in the regulation of, 29,

67

Oxidase

amine. See Amine oxidase(s)

monoamine. See Monoamine oxidaseOxidative phosphorylation, uncoupling of, as a mech-

anism of drug action, 7, 335

N-Oxides, pharmacology and biochemistry of, 21, 325Oxygen, pulmonary, toxicity, 23, 37

Pain, measurement of, prototype for quantitativestudy of subjective responses, 9, 59

Parasympathetic control of the heart, 25, 119Peptide hormones. See under Hormone(s)Peripheral auditory system, pharmacology of trans-

mission in, 28, 95Peripheral circulation, control of resistance, exchange,

and capacitance functions in, 20, 117Peripheral nerve, neuropharmacology of, 4, 168

Permeability. See Capillary, Membrane, and Vascular

permeability

Permeability coupling, stimulus-. See Stimulus-perme-

ability coupling

pH, ionization, biological activity, and, 4, 136

Pharmacokinetics, linearity and superposition in, 26,3

Phenylalanine and tetrahydropteridines, 18,61Pheochromocytoma, 18,651

catecholamine metabolism in patients with, 11, 374catecholamine-producing neural tumors other than,

18, 659

Phosphofructokinase, activation of, 18, 173Phospholipase A and polypeptide toxins, pharmacol-

ogy of, actions of snake venoms on nerve and

muscle, 17, 393

SUBJECT INDEX, VOLUMES 1-30 657

Phosphorylaseactivity

and function, actions of autonomic drugs on, 17,27

heart and, catecholamine influence on, 18, 197

of isolated rat heart, effect of sympathomimetic

amines on, 11, 466

adenosine-3’,5’-phosphate and, relation to the ac-tions of catecholamines and other hormones,

12, 265skeletal muscle, activation of, 18, 163

Photoproteins as biological calcium indicators, 28, 1

Pineal tissues. See under Tissue(s)

Placebos, pharmacology of, 11, 689

Plasmahuman, estimation of epinephrmne and norepineph-

rime in, by the trihydroxyindole method, 11,273

iron. See under Iron

pressor amines, suitability of the ethylenediamine

method of Weil-Malherbe and Bone andmodifications for quantitating, 11, 289

proteins. See under Protein(s)Platelet function, factors influencing adhesion, release,

and aggregation, 22, 97Poikilotherinic vertebrates. See under Vertebrates

Polydipsia

function ofschedule-induced, in establishing ethanolas positive reinforcer, 27, 465

schedule-induced, oral intake of drugs and, 27, 477,

489

Polypeptide(s)

active, of nonmammalian origin, 28, 127toxins. See under Toxin(s)

Porphyrinliver, disturbances of metabolism caused by drugs,

19, 523metabolism, drugs and, 6, 133

Potassium

exchanges of, related to organs and systems, 3, 42sodium-, adenosine triphosphatase, pharmacologi-

cal, physiological, and biochemical aspects,

27, 3

Potentiation and synergism, with reference to combi-

nation of structural analogues, 8, 339

Prostacyclin and thromboxane A2, prostaglandin en-doperoxides, pharmacology and endogenousroles of, 30, 293

Prostaglandin(s)

anti-. See Antiprostaglandins

biosynthesis inhibited by drugs, 26, 33

endoperoxides, thromboxane A2, and prostacydlin,pharmacology and endogenous roles, 30, 293

family of biologically active lipids, 20, 1

Protein(s)conjugates, drug, principles and methods for prep-

aration of, for immunological studies, 25, 271epinephrmne and, in the adrenal medulla, adrenocor-

tical control of the biosynthesis of, 24, 411photo-. See Photoproteins

plasma

and drugs, interactions of, 1, 102

fluids, electrolytes and, role in experimental trau-

matic shock and hemorrhage, 6, 489

synthesis

mammalian, inhibition by antibiotics, 21, 213puromycin inhibition of, 16, 223

Protoplasm, cell, and contraction of muscle, modelsfor study of, 7, 97

Psychobiology techniques and results ofstudies of self-administration of drugs, use in, 27, 545

Psychomimetic drugs. See under Drugs(s)Psychopharmaca, demonstration and mapping of cen-

tral neurons containing dopamine, noradren-aline, and 5-hydroxytryptamine and their re-

actions to, 18, 727Psychotropic drugs. See under Drug(s)

Pulmonary circulation, pharmacology of, 12, 159Pulmonary oxygen toxicity, 23, 37Purinergic nerves, 24, 509Puromycin, inhibition of protein synthesis by, 16, 223

Pyrogens

bacterial, 9, 427monoamines, cations, and, actions on central control

of body temperature, 26, 289

Pyrrolizidine (Senecio) alkaloids, toxic actions of, 22,

429

Quaternary ammonium compounds, acetylcholine-re-

lated, excitatory and anti-curare propertiesof, at the neuromuscular junction, 5, 1

Quinidine-like drugs. See under Drug(s)

Radiation, ionizing, and chemical protection in mam-mals, pharmacological aspects, 10, 437

Radioimmunoassay

of digitalis glycosides, clinical value of, 25, 219

methodology, application to problems of heteroge-neity of peptide hormones, 25, 161

Radioreceptor assay, application to circulating insulin,

growth hormone, and to their tissue receptorsin animals and man, 25, 179

Rat

heart, perfused, kinetic studies of epinephrine ef-

fects in, 18, 205

isolated heart of, effect of sympathomimetic amineson phosphorylase activity of, 11, 466

liver, perfused, gluconeogenesis stimulation from

lactate by epinephrine, glucagon, and cyclic

3’, 5’-adenylate in, 18, 181

uterus, depolarized, calcium and the relaxant effect

of isoproterenol in, 18, 495

Rauwolfia, pharmacology of, 8, 435Receptor(s)

enzymes and, steric effects in catecholamine inter-actions with, 18, 131

pharmacological, 20, 49approaches to the molecular nature of, 21, 131

physiological, antibodies and, role in cardiovascular

diagnosis, therapy, and research, 25, 215

SUBJECT INDEX, VOLUMES 1-30

Receptor(s)-continued

regulation of membrane permeability, role of cal-

cium in, 30, 209See also Adrenergic, Cholino-, Hormone, Mech-

ano-, Sensory, and Tissue receptors

Red blood cell, sugar transport in, structure-activityrelationships in substrates and antagonists,13,39

Redox substances and antioxidants influence on signs

of vitamin E deficiency, 9, 1Reflexes, intrinsic intestinal, pharmacological analysis

of, 16, 301

Renal and cardiovascular actions of dopamine, poten-

tial clinical application, 24, 1Renal transport mechanisms, functional characteris-

tics of, 2, 227

Renal tubular excretion of organic bases, 12, 1Ream

-angiotensin-aldosterone, measurements of, 25, 249

-angiotensin system, 17, 143

hypertensin and, pharmacology of, 8, 25Reproduction

accessory organs of, in mammals, control of cell andtissue transport by sex hormones, 27, 207

autonomic nervous control of, circulatory and otherfactors, 24, 657

Reserpine

biological fate of, 28, 179norepinephrine depletion by, 18, 561

Respiratory tract fluid and expectorants, 6, 521Retina, localization of specific cholinesterase in, 6, 47Retinal tissues. See under Tissue(s)

Rhesus monkeys. See under Monkey(s)

Ryanodine, pharmacology of, 21, 1

Salicylates, pharmacology of, certain aspects, 1, 353Saxitoxin and tetrodotoxin, significance in the study

of excitation phenomena, 18, 997

Secretion, gastric. See Gastric secretion

Secretory cycle in the adrenal medulla, 24, 385

Sedative abuse, experimental human drug self-admin-

istration, methodology and application tostudy of, 27, 523

Senecio (pyrrolizidime alkaloids), toxic actions of, 22,429

Sensory and central transmission, 6, 85, 95, 103Sensory receptors, effect of acetylcholime-like sub-

stances on, 8, 97

Serotonin

catecholamines and, release of, by drugs, 14, 531

epinephrine and, actions on intact and broken cellpreparations from the liver fluke, Fasciola

hepatica, 11, 465

morphine, barbiturates, and, antibodies to, 25, 281

Serum dopamine $-hydroxylase, 30, 133

Sex hormones. See under Hormone(s)Sister chromatid exchange. See under Chromatid ex-

change

Shock, experimental traumatic, and hemorrhage, role

of fluids, electrolytes, and plasma proteins in,

6, 489

Sinus and carotid body, action of drugs on, 7, 119Sleep and drugs, 20, 273

Skeletal muscle. See under MuscleSnake venoms, actions of, on nerve and muscle, phar-

macology of phospholipase A and polypep-tide toxins, 17, 393

Sodium

-calcium interactions in mammalian smooth muscle,

30, 167-potassium adenosine triphosphatase, pharmacolog-

ical, physiological, and biochemical aspects,

27, 3

Spermatogenesis, actions of drugs on, biochemical as-

pects of, 19, 21Spermidine, spermine, and related amines, 16, 245Spermine, spermidine, and related amines, 16, 245

Spinal cord, depressant drugs, 1, 243

Spinal reflexes, action of anticholinesterases on, fol-

lowing intra-arterial injection, 6, 49

Spleen, drug action on smooth muscle of capsule and

blood vessels of, 25, 373Steroid(s)

adrenocortical. See Adrenocortical steroids

cortico-. See Corticosteroids

gonadotropin-, interrelationships, 25, 189hormones. See under Hormone(s)

pharmacology, selected aspects of, 15, 123

Stimulus-permeability coupling, role of calcium in thereceptor regulation of membrane permeabil-ity, 30, 209

Storage and metabolism of catecholamines, role ofmonoamine oxidase in, 16, 179

Structural analogues

synergism and potentiation with special reference tothe combination of, 8, 339

Sugar transport in red blood cell, structure-activity

relationships in substrates and antagonists,

13, 39Sulphides and bis(2-haloethyl) amines, pharmacology

of, 2, 281

Surface membranes, functional components of, poten-tial targets for pharmacological manipula-

tion, 30, 371Sweating, pharmacology of, 7, 365

Sympathectomy, immuno-, 18, 619Sympathectomy, surgical, and adrenergic function, 18,

611

Sympathetic activity and neurotransmitter depletionin congestive heart failure, 18, 685

Sympathetic ganglia, transmission and block in, 6, 69

Sympathetic nerve endings, release of norepinephrineand other amines from, biochemical aspects,18, 513

Sympathetic nervesstorage of norepinephrine in, 18, 439

Sympathetic nervous system

molecular biology of, 24, 165

SUBJECT INDEX, VOLUMES 1-30 659

regulation of catecholamine metabolism in, 24, 365

Sympathetic neuron(s)

axons of, transport of enzymes in vivo and prop-erties of axonal sprouts in vitro, 24, 245

subcellular localization of noradrenaline in, 24,

435

Sympathetic outflow to adrenal medulla and adipose

tissue, effects of glucose deprivation on, 18,303

Sympathetic regulation of metabolism, 19, 367

Sympathetic tissues. See under Tissue(s)

Sympathomimetic amines

actions of, and their antagonists on skeletal muscle,

21, 27

effect of, on phosphorylase activity of isOlated ratheart, 11, 466

indirectly acting, 18, 551

mechanisms of hypersensitivity and subsensitivity,

18,629

supersensitivity and subsensitivity to, 15, 225

Symposia

Catecholamimes, 11, 233-566Catecholamines (second), 18, 1-804

Control of Drug-taking Behavior by Schedules ofReinforcement, 27, 291-545

Drug Antagonism, 9, 211-268Immunopharmacology, 25, 157-363Marihuana and Its Surrogates, 23, 263-380

Neurohumoral Transmission, 6,3-132

Regulation of Catecholamine Metabolism in theSympathetic Nervous System, 24, 163-431

Workshop on Cellular and Molecular Toxicology,30, 333-616

Synapseadrenergic

central, 18, 717

junction potential at, 18, 481

ganglionic, motor endplate and, transmission at, 6,71

nerve-muscle, acetylcholine receptors and acetyl-cholinesterase accumulation at newlyformed, 30, 411

Synaptic mechanisms in autonomic ganglia, modifi-cation by drugs, 18, 839

Synergism and potentiation, with reference to combi-nation of structural analogues, 8, 339

Synthesisdegradation and, of catecholamine, application of

immunological techniques to regulating en-zymes, 24, 349

Synthesisepinephrine, adrenocortical control of, 23, 1metabolism and, ofcatecholamines, influence of spe-

cific nutrients on, 24,349norepinephrine

effect ofneuronal activity and nerve growth factoron, 24, 255

in intact tissue, modification by drugs and during

short-term adrenergic nerve stimulation, 24,

203

protein. See Protein synthesis

Systems and organs, exchanges of potassium relatedto, 3, 42

Temperature regulation, physiology and pharmacol-

ogy of, 13, 361

Tetrahydrocannabinol(s)

biological disposition of, 23, 273

derivatives, synthetic, pharmacological actions of,23, 295

synthetic derivatives, central nervous system ac-

tions of, 23, 317

i�9-Tetrahydrocannabinol, metabolism and dispositionof, in man, 23, 371

Tetrahydropteridines, phenylalanime and tyrosine hy-

droxylases and, 18, 61

Tetrodotoxin and saxitoxin, significance in the study

of excitation phenomena, 18, 997THAM. See Tria(hydroxymethyl)aminomethane

Thirst and hunger, physiological and pharmacologicalaspects of the control of, 13, 1

Thromboxane A2 and prostacydlin, prostaglandin en-doperoxides, pharmacology and endogenousroles of, 30, 293

Thyroid function, factors controlling, with especialreference of views on antithyroid substances,7, 301

Thyroid tissue. See under Tissue(s)

Tin compounds, toxicology of, 11, 211Tissue(s)

adiposecyclic 3’,5’-AMP and lipolytic effects of hormones

on, 18, 237drug and hormone action on, biochemical aspects

of, 25, 67glucose deprivation effects on sympathetic out-

flow to, 18, 303and blood changes, induced by norepinephrmme-stim-

ulated mobilization of free fatty acid, 18,241chromaffim, 18,453

connective, metabolism of mucopolysaccharides of,7, 1

intact, catecholamine formation in, 11, 358

lungs and, inert gas exchange at, theory and appli-cations of, 3, 1

nervous

acetylcholine metabolism of, 6, 39adrenal medulla and, role ofL-dopa decarboxylase

in the biosynthesis of catecholamines in, 11,

317

neural and retinal, pineal-related, indole derivativesof, 17, 321

noradrenergic, storage particles in, 18, 425pineal and related neural and retinal, indole deriv-

atives of, 17, 321receptors, of circulating insulin and growth hor-

mone, application of radioreceptor assay to,

25, 179

660 SUBJECT INDEX, VOLUMES 1-30

Tissue(s)-continuedretinal and neural, pineal-related, indole derivatives

of, 17, 321

subcutaneous connective, absorption of drugs from,

13, 441

sympathetic, electron microscopy of, 18, 387

thyroid, intermediary metabolism of, and drug ac-tion, 15, 43

transport, control in mammals by sex hormones, 27,207

Toxic action of pyrrolizidine (Senecio) alkaloids, 22,429

Toxicitychronic, experimental methods used in determining,

6, 191

metabolism and, of methanol, 7, 399

pulmonary oxygen, 23, 37Toxicology

application of basic concepts to research in, 30, 605

drug metabolism, implications, 30, 457of herbicides, 14, 225of marihuana, 23, 279new era, 30, 351pharmacology and, of antibiotics, 2, 1

Toxins

bacterial, pharmacology of, 16, 1

ofAmanitaphalloides, chemistry and toxicology of,

11,87

polypeptide, phospholipase A and, pharmacology of,

actions ofsnake venoms on nerve and muscle,17, 393

Transferase, catechol-O-methyl. See Catechol-O-

methyl transferase

Transmitter reactivity, autonomic neuroeffectortrans-mission and, ontogenetic development of, inembryonic and fetal hearts, 29,3

Tranquilizers and anesthetics, membrane actions of,

24, 583Trihydroxyindole method

development and applications of, for catechol-amimes, 11, 262

estimation of epinephrine and norepinephrine con-

centrations in human plasma by, 11, 273

Trihydroxyimdole procedure, techniques to improve

the specificity of, 11, 269Triphosphatase, adenosine. See Adenosine triphos-

phatase

Tris(hydroxymethyl)aminornethane (THAM), phar-macology of, 14,447

Thberculosis

chemotherapy of, wider aspects of, 5, 421drug treatment of, 15, 169

Tumors

catecholamine-producing neural, other than pheo-

chromocytoma, 18,659catecholamine-secreting, chemistry and pharmacol-

ogy of, 18, 645

growth, hormonal regulation of, 9, 367Tyrosine hydroxylase(s) 18,43

dopa decarboxylase and, changes in, induced by

pharmacological agents, 24, 269

tetrahydropteridines and, 18,61

Uric acid, role in biological processes and influence

upon it of physiological, pathological, and

pharmacological agents, 5, 231

Urinary metabolite, 3-methoxy-4-hydroxy-D-mandelic

acid, of norepinephrine and epinephrine, for-

mation of, 11, 394

Urinebile and, secretion of organic anions in formation of,

11, 109

blood andadrenaline and noradrenaline in, 6, 35

catecholamine assays, spectrophotofluorimetricobservations on, 11, 296

estimation of metanephrine, normetamephrine, and3,4-dihydroxymandelic acid in, 18, 331

human, metabolic products of adrenaline and nor-adrenaline in, 11, 416

Uterus, rat, depolarized, calcium and the relaxant ef-

fect of isoproterenol in, 18, 495

Vascular permeability, increased, mediation of, in in-

flammation, 14, 251Vascular smooth muscle. See under Muscle

Vasodilatation, antidromic, in the paw of the cat, 6,99Venoms, snake. See Snake venom(s)Vertebrate mechanoreceptors, effects of drugs on, 16,

341

Vertebrates

evolution of autonomic innervation of visceral andcardiovascular systems in, 21, 247

poikilothermic, invertebrates and, pharmacology of,14, 281

Viral diseaseschemotherapy of, 15, 407

advances in, 19, 209influence of dietary, hormonal, and other factors

in, 8, 199

Virus infections, influence of dietary, hormonal, and

other factors, 8, 199

- Visceral and cardiovascular system, evolution of au-tonomic innervation of, in vertebrates, 21,247

Vitamin A, metabolism of, 19,559Vitamin B5, pharmacological aspects, 16, 113Vitamin E deficiency, influence of antioxidants and

redox substances on, 9, 1Vomiting, physiology and pharmacology of, 5, 193

Weil-Malherbe and Bone ethylenediamine method,suitability of and modifications for quantitat-

ing plasma presser amines, 11, 289