INDEX

663

Volume 177, April-June 1971

Acetaldehyde-induced catecholamine secretionfrom cow adrenal medulla, 109

Acetylcholine

blocking action of benzyltrimethylammoniumbromide, 369

effects on reserpine-treated rabbit aortic strips,127

release from ileum, effects of germine-3-mono-

acetate, 181Acetyistrophanthidin, effect on carotid sinus reflex

mechanism, 650

Adenosine monophosphatedibutyryl cyclic, effect on tryptophan concen-

tration in rat brain, 475dibutyryl cyclic, -induced lipolysis in rat, effects

of cardiac glycosides, 284Adrenal gland

medulla, cow, acetaldehyde-induced catechola-

mine secretion, 109medulla, effect of coichicine, ymca alkaloids

and deuterium oxide on role of microtubules

in catecholamine release, 102

tyrosine hydroxylase, bovine, subcellular dis-

tribution and aggregation, 155Adrenergic neuron

blockers, reserpine and, antagonism of effects ofcocaine, norepinephrine and ionic stimulantson rat vas deferens, 136

sodium-dependent , optically specific and reser-pine-sensitive amine carrier mechanism at, 389

Adrenergic responses, of aortic strips from youngand old rabbits, cocaine-induced potentiation,

621Agonists

blocking action of benzyltrimethylammoniumbromide, 369

pharmacological estimation of drug-receptordissociation constants, 1

Alkaloids, ymca, colchicine, deuterium oxide and,effect on role of microtubules in catecholaminerelease from adrenal medulla, 102

Amine(s)carrier mechanism, sodium-dependent , optically

specific and reserpine-sensitive, at adrenergicneuron, 389

tricyclic, structure-activity relationship, 219Amino acids, transport and incorporation into

rabbit atrial tissue in vitro, effects of ouabain,calcium and potassium, 398

a-Aminoisobutyric acid, transport and incorpora-tion into rabbit atrial tissue in vitro, 398

Amphetamine, effects on dopamine synthesis in

rat striatum, 196

d-Amphetamine, effect on tryptophan concentra-

tion in rat brain, 475Amyl nitrite, nitroglycerin and, hemodynamic

effects in conscious dog, 426Analgesia

produced by optical isomers of pentazocine in

rat, 500

running, tolerance, physical dependence and,

opiate-induced, effects of p-chlorophenylala-nine, 309

Anesthetic agents, effect on calorigenic responses

to 2,4-dinitrophenol and L-thyroxine in rats,514

Angiotensin

ganglionic stimulation, mechanism of positiveinotropic and chronotropic effects of, 48

in dog hindpaw, effects of prostaglandins E1, E2,

Fia and F2,, on vasoconstrictor responses, 614interaction with norepinephrine on cat nicti-

tating membrane in vivo, 633Angiotensin I, conversion by kininase II, 291Antagonists , competitive , pharmacological esti-

mation of drug-receptor dissociation con-

stants, 13Aorta

rabbit, effects of lanthanum on 45Ca movements

and on contractions induced by norepineph-rine, histamine and potassium, 415

rat, rabbit and guinea pig, norepinephrine con-centrations, 119

strips, from young and old rabbits, adrenergicinnervation and cocaine-induced potentiationof responses, 621

strips , rabbit , reserpine -induced supersensitiv-

ity, 127

thoracic, rabbit, entry, accumulation and dis-

tribution of H-norepinephrine, 613Apomorphine, effect on tryptophan concentration

in rat brain, 475

Artery, wall, entry of ‘H-norepinephrine, 613Atria

guinea pig, electrically driven, propranolol-in-

sensitive effects on action potential repolari-zation, 85

guinea pig, isolated, negative chronotropiceffects of MeN A-343 and nicotine, insensi-tivity to blockade by tetrodotoxin, 40

rabbit, effects of ouabain, calcium and potas-sium on in vitro transport and incorporationof amino acids, 398

Atropine

effects on hypothermic responses in morphine-dependent rhesus monkey, 317

664 INDEX

influence on negative chronotropic effect ofMeN A-343, 40

Axelrod, J., see Lemberger, L., 169Axons, giant, squid, active form of pentobarbital

in, 25

Babington, R. G. and Wedeking, P. W. : The in-fluence of cinanserin and selected pharmaco-logic agents on experimental allergic enceph-alomyelitis (EAE), 454

Bachur, N. R. : Daunorubicinol, a major metabo-

lite of daunorubicin: Isolation from humanurine and enzymatic reactions, 573

Bachur, N. R. and Gee, M. : Daunorubicin metabo-11am by rat tissue preparations, 567

Bariumhypokalemic and cardiovascular effects, 433

ion, effects on reserpine-treated rabbit aorticstrips, 127

ion, responses of superfused rat vas deferens, 136Baur, E. W. : The structure-activity relationship

of tricyclic amines, 219Becker, B. A., see Gibson, J. E., 256Beck, L., see DuCharme, D. W., 565-Benzoyloxy-2-iminohexahydropyrimidine hy-

drochioride, interference with excitation, 34

Benzyltrimet hylammoni urn bro mide, studies mnonspecific blocking action of, 369

Berkowitz, B. A. and Way, E. L. : Analgesic ac-tivity and central nervous system distributionof the optical isomers of pentazocine in therat, 500

Berkowitz, B. A., Tarver, J. H. and Spector, S.:Norepinephrine in blood vessels : Concentra-tion, binding, uptake and depletion, 119

Berman, L. B., see Roza, 0., 433

Bernstein, J., see Poisner, A. M., 102Besson, M. J., Cheramy, A. and Glowinski, J.:

Effects of some psychotropic drugs on dopa-

mine synthesis in the rat striatum, 196Bevan, J. A., see T#{246}r#{246}k,J., 613Bhagat, B. D., see Dhalla, N. S., 96Biirubin, effects of dimethyl sulfoxide in rabbits,

520

Bishop, V. S., see O’Rourke, R. A., 426Blickens, D. A. and Riggi, S. J. : Carbohydrate

metabolism in normal and hyperglycemicanimals treated with 1-methyl-4-(3-methyl-5-

isoxazolyl)pyridinium chloride and phen-formin, 536

Bloodflow, hepatic, effect on removal rate of oxyphen-

butazone in dog, 246man, reactions between hydroxylamine and

hemoglobin derivatives, 440rat, pentazocine levels in, 332

Blood vessels, norepinephrine in, 119Bohn, D. L., see Fanelli, G. M., Jr., 591

Borzelleca, J. F., see Putney, J. F., 263Brain

cat, effects of a-methyl-meta-tyrosine on spon-taneous and caudate-induced electroenceph-alogram activity and regional catecholamines,

481monoamines, relation with anticonvulsant ac-

tion of inhibitors of carbonic anhydrase, 206mouse, effect of decaborane on histamine forma-

tion, 177norepinephrine, sleep and, in cats, effects of

a-methyltyrosine, 188rat, effect of psychotropic drugs on tryptophan

concentration, 475rat, levels of optical isomers of pentazocine, 500

rat, pentazocine levels, 332rat, subcellular distribution of 4-’4C-diphenyl-

hydantoin, 342uptake of morphine, acute toxicity and, effect

of dactinomycin, 326Bretylium, responses of superfused rat vas defer-

ens, 136Brody, M. J., see Kadowitz, P. J., 641Buckley, J. P., see El Defrawy, S., 276Bulbocapnine , effect on tryptophan concentration

in rat brain, 475

Bush, M. T., see Gerber, N., 234

Calciumassociation with positive inotropic effect of

ouabain, 78effects on lipolysis in rats, 284

ion, effect on cocaine-induced potentiation ofadrenergic responses of aortic strips from

young and old rabbits, 621ion, responses of superfused rat vas deferens, 136

ouabain, potassium and, effects on transport andincorporation of amino acids into rabbit atrial

tissue in vitro, 398Calcium-45, movements, in vascular smooth mus-

cle, effects of lanthanum, 415Calorigenesis, responses to 2,4-dinitrophenol and

L-thyrOXine in rats, effect of sedating agents,

514

Carbohydrate, metabolism in normal and hyper-glycemic animals treated with 1-methyl-4-(3-methyl-5-isoxazolyl)pyridinium chlom ide andphenformin, 536

Carbonic anhydrase, relation between mono-amines in brain and anticonvulsant action of

inhibitors of, 206Carbon tetrachloride, effects on hepatic drug

metabolizing system, comparison with halo-

thane, 556Cardiac glycosides, mechanism of antilipolytic

effects, 284Cardiovascular system, effects of barium, 433Carinamide, renal effects in chimpanzee, 591

INDEX 665

Carotid sinus, reflex changes produced by digi.

talis, 650Cat(s)

brain, effects of a-methyl-mela-tyrosine onspontaneous and caudate-induced electro-encephalogram activity and regional cate-

cholamines, 481

carotid sinus reflex changes produced by digi-

talis, 650dissociation of cardiac inotropic and transmem-

brane action potential effects of ouabain, 78

effects of a-methyltyrosine on sleep and brainnorepinephrine, 188

nictitating membrane, interaction between an-giotensin and norepinephrine in vivo, 633

spinal excitatory and depressant effects of

sodium diphenylthiohydantoinate, 350

Catabolism, synthesis, binding and, of 3H-hista-mine in nonmast cells in vivo, 579

Catecholamine(s)biosynthesis, implications of subcellular die-

tribution of tyrosine hydroxylase, 155effects on action potential repolarization in

electrically driven guinea-pig atria, 85levels, brain, cat, effects of a-methyltyrosine,

188

positive inotropic effects, comparison with

ouabain, 78regional, in cat brain, effects of a-methyl-meta-

tyrosine, 481release from adrenal medulla, effect of colchi-

cine, ymca alkaloids and deuterium oxide onrole of microtubules, 102

secretion from cow adrenal medulla, acetalde-hyde-induced, 109

stores of isolated rat heart perfused with sub-

strate-free medium, 96Cell, nonmast, histamine kinetics, 579Central nervous system, rat, distribution of opti-

cal isomers of pentazocine, 500Cervoni, P. and Reit, E. : Interaction between

angiotensin and bloodborne exogenous nor-epinephrine on the cat nictitating membranein vivo, 633

Cheney, D. L. and Goldstein, A. : The effects ofp-chlorophenylalanine on opiate-induced run-ning, analgesia, tolerance and physical de-

pendence in mice, 309Cheramy, A., see Besson, M. J., 196Chimpanzee, renal effects of uricosuric agents, 591

p-Chlorophenylalanineeffect on opiate-induced running, analgesia,

tolerance and physical dependence in mice,309

effect on tryptophan concentration in rat brain,475

Chiorothiazide, renal effects in chimpanzee, 591Chiorpromazine

effect on tryptophan concentration in rat brain,475

inhibition of norepinephrine biosynthesis inguinea-pig vas deferens, 146

Cinanserin, influence on experimental allergic en-

cephalomyelitis, 454Cleaves, C. A., see Narahashi, T., 25

Cocaine-induced potentiation of adrenergic responses of

aortic strips from young and old rabbits,

adrenergic innervation and, 621inhibition of norepinephrine synthesis in guinea-

pig vas deferens, 146norepinephrine, ionic stimulants and, effects on

rat va,s deferens, antagonism by adrenergic

neuron blockers and reserpine, 136

Colasanti, B., see Khazan, N., 491Colchicine, ymca alkaloids, deuterium oxide and,

effect on role of microtubules in catechola-mine release from adrenal medulla, 102

Cook, C. E., see Freudenthal, R. I., 468

Cooper, T., see Dempsey, P. J., 78Cortex, cerebral, rat, subcellular distribution of

4J�C..diphenylhydantoin, 342Corticosterone, somatotropin and, role in stress-

mediated decrease in liver hexobarbital me-

tabolism, 227Cow

adrenal medulla, acetaldehyde-induced c ate-cholamine secretion, 109

adrenal medulia, effect of colchicine, ymcaalkaloids and deuterium oxide on role ofmicrotubules in catecholamine release, 102

adrenal tyrosine hydroxylase, subcellular die-tribution and aggregation, 155

Cranston, R. D. and Smith, R. P. : Some aspects of

the reactions between hydroxylarnine andhemoglobin derivatives, 440

Creatine phosphokinase, effects of dimethvl sulfox-

ide in rabbits, 520Cyclophosphamide , placental transfer in mice,

effect of phenobarbital and SKF 525A , 256

Cytoplasm, cell, localization of tyrosine hydroxyl-

ase, 155

Dactinomycin, effect on acute toxicity and brain

uptake of morphine, 326Daunorubicin

metabolism by rat tissue preparations, 567metabolite (daunorubicinol) , isolation from

human urine and enzymatic reactions, 573Daunorubicinol , metabolite of daunorubicimi , iSO-

lation from human urine and enzymatic reac-

tions, 573

Davis, D. C., Schroeder, D. H., Gram, T. E.,Reagan, H. I. and Gillette, J. R. : A compari-

son of the effects of halothane and CCL on thehepatic drug metabolizing system, 556

666 INDEX

Dayton, P. G., see Whitsett, T. L., 246Decaborane, effect on histamine formation in

mice, 177Deguchi, T., see Narahashi, T., 25Dempsey, P. J., McCallum, Z. T., Kent, K. M.

and Cooper, T. : Dissociation of cardiac mo-tropic and transmembrane action potentialeffects of ouabain, 78

2-Deoxyglucose, uptake mechanisms in guinea-pigseminal vesicles, 447

Deuterium oxide, colchicine, ymca alkaloids and,effect on role of microtubules in catecholaminerelease from adrenal medulla, 102

Dhalla, N. S., Bhagat, B. D., Sulakhe, P. V. andOlson, R. E. : Catecholamine stores of theisolated rat heart perfused with substrate-freemedium, 96

4,4’-Diacetamidodiphenylsulfone, action on Plas-

modium berghei, 3014, 4’-Diaminodiphenylsulfone, action on Plas-

modium berghei, 301Diaphragm, rat, glycogen content, effects of phen..

formin at simulated high altitude, 276Diazepam, calorigenic responses to 2, 4-dinitro-

phenol and L-thyroxine in rats, 514Diecke, F. P. J., see Dretchen, K., 3694,4’-Diformamidodiphenylsulfone, action on Plas-

modium berghei, 301Digitalis, carotid sinus reflex changes produced

by, 650Digitoxin, effects on lipolysis in rats, 284Dihydroergotamine, antagonism of effects of epi-

nephrine in electrically driven guinea-pig

atria, 8�5Dimethyl sulfoxide

-lenticular changes in rabbits, 528

toxicology, 5202,4-Dinitrophenol, L-thyroxine and, calorigenic

responses in rats, effect of sedating agents, 514Dipeptide hydrolase, characterization, 291

Diphenoxylate, biotransformation in rat and dog,

546

Diphenylhydantoin, effects in cat spinal cord,

comparison with diphenylthiohydantoinate,

3504..iOCDiphenylhydantoin, subcellular distribution

in rat brain, 342

Diphenyithiohydantoinate, spinal excitatory and

depressant effects, 350

Dog(s)

biotransformation of diphenoxylate, 546conscious, hemodynamic effects of nitroglycerin

and amyl nitrite, 426

direct and systemic effects of guanethidine on

renal function, 69

effect of L-dopa on chronotropic responses tocardioaccelerator nerve stimulation , 409

effect of hepatic blood flow on removal rate ofoxyphenbutazone, 246

effect of renal pressor and sympathetic nervoussystems on vascular capacity during hypo-tension, 56

heart, mechanism of positive inotropic andchronotropic effects of angiotensin, 48

hindpaw, effects of prostaglandins E1, E2, F1,,and F2,, on adrenergic vasoconstriction, 641

hypokalemic and cardiovascular effects of bar-

mm, 433

L-Dopa, effect on chronotropic responses to cardio-accelerator nerve stimulation in dogs, 409

Dopaminein brain, relation with anticonvulsant action of

inhibitors of carbonic anhydrase, 206in cat brain, effects of a-methyl-meta-tyrosine,

481synthesis, in rat striatum, effects of some psy-

chotropic drugs, 196Dretchen, K., Diecke, F. P. J. and Long, J. P.:

Studies on the nonspecific blocking action ofbenzyltrimethylammonium bromide (BTM),

369Drug-receptor dissociation constants

agonists, pharmacological estimation, 1competitive antagonists , pharmacological esti-

mation, 13

DuCharme, D. W. and Beck, L. : The relativeeffect of the renal pressor and sympatheticnervous systems on vascular capacity duringhypotension, 56

El Defrawy, S. and Buckley, J. P. : Metaboliceffects of phenformin at simulated high alti-

tude, 276Electroencephalogram

activity, spontaneous and caudate-induced, in

cat brain, effects of a-methyl-meta-tyrosine,

481voltage, decline during morphine abstinence in

rat, 491El-Mazati, A. M. and Way, E. L. : The biologic

disposition of pentazocine in the rat, 332

Embryo, mouse, effect of phenobarbital and SKF525A on cyclophosphamide levels, 256

Encephalomyelitis, experimental allergic, in-.fluence of cinanserin and pharmacologic

agents, 454

Enzymeangiotensin I converting, characterization, 291reactions, man, isolation of metabolite of dauno-

rubicin from, 573Epinephrine , propranolol-insensitive effects on

action potential repolarization in electricallydriven guinea-pig atria, 85

Erd#{246}s,E. G., see Yang, H. Y. T., 291Ernau, M. C., see Narahashi, T., 25

INDEX

Ethynodiol diacetate, metabolism by rat and

human liver, 468

Fanelli, G. M., Jr., Bohn, D. L. and Reilly, S. S.:Renal effects of uricosuric agents in thechimpanzee, 591

Farr, W. C. and Grupp, G. : Ganglionic stimula-tion : Mechanism of the positive inotropic andchronotropic effects of angiotensin, 48

dl-Fenfiuramine, effect on tryptophan concentra-tion in rat brain, 475

Fernandez, J. see O’Rourke, R. A., 426Forth, J., see Freudenthal, R. I., 468Frazier, D. T., see Narahashi, T., 25

Freudenthal, R. I., Cook, C. E., Forth, J., Rosen-feld, R. and Wall, M. E. : The metabolism ofethynodiol diacetate by rat and human liver,

468Frog

nicotine-induced depolarization and stimulationof potassium efflux in striated muscle, 377

sartorius muscle, effects of HM-197 on electricalproperties, 34

Fujiwara, M., see Shibata, S., 621

Gaffney, T. E., see Whitnack, E., 409

Galindo, A. : Procaine, pentobarbital and halo-thane : Effects on the mammalian myoneuraljunction, 360

Ganglia, sympathetic, dog, stimulation, mecha-nism of positive inotropic and chronotropic

effects of angiotensin, 48Garden, G., see Karim, A., 546Gee, M., see Bachur, N. R., 567

Gerber, N., Lynn, R., Holcomb, R., Weller, W. L.and Bush, M. T. : The metabolism of hexo-barbital in mice and methodology for isolationand quantitation of its metabolites in vivoand in vitro, 234

Germine-3-monoacetate, effects on isolated ratand guinea-pig ileum, 181

Gessa, G. L., see Tagliamonte, A., 475Gibson, J. E. and Becker, B. A. : Effect of pheno-

barbital and SKF 525A on placental transferof cyclophosphamide in mice, 256

Gillette, J. R., see Davis, D. C., 556Glue, R. A., see Quest, J. A., 650Gland

prostate, uptake of nonutiizable sugars, 447submaxillary, rat, distribution of i4C�alicylic

acid in vitro, 263

Gleason, L. N., see Vogh, B. P., 301Glowinski, see Besson, M. J., 196Gluckman, M. I., see Yu, D. H., 284Glucose, effects of dimethyl sulfoxide in rabbits,

520

Glycogen, rat liver, heart and diaphragm, effectsof phenformin at simulated high altitude, 276

Goldman, W. J. and Scriabine, A. : Some effects of

germine-3-monoacetate (GMA) on isolated ratand guinea-pig ileum, 181

Goldstein, A., see Cheney, D. L., 309Goodman, F. R. and Weiss, G. B. : Effects of

lanthanum on 4#{176}Camovements and on con-tractions induced by norepinephrine, hista-mine and potassium in vascular smooth mus-cle, 415

Gram, T. E., see Davis, D. C., 556

Gray, W. D. and Rauh, C. E. : The relation be-tween monoamines in brain and the anticon-vulsant action of inhibitors of carbonic an-hydrase, 206

Greenberg, S. and Long, J. P. : The effects of co-caine, norepinephrine and ionic stimulantsin the isolated, superfused rat vas deferens:Antagonism by “adrenergic neuron blockers”

and reserpine, 136Green, R. D., see Taylor, J., 127Grupp, G., see Farr, W. C., 48Guanethidine

direct and systemic effects on renal function, 69

effect on sodium-dependent, optically specificand reserpine-dependent amine carrier mech-anism in rabbit heart, 389

responses of superfused rat vas deferens , 136

Guinea pig(s)atria, electrically driven, propranolol-insensi-

tive effects on action potential repolarization,85

atria, isolated, negative chronotropic effects ofMcN A-343 and nicotine, insensitivity toblockade by tetrodotoxin, 40

ileu.m, rat and, some effects of germine-3-mono-acetate, 181

norepinephrine in blood vessels, 119

partially eviscerated, metabolic effects of 1-methyl -4 - (3-methyl -5-isoxazolyl)pyridinium

chloride, 536plasma and kidney, characterization of dipep-

tide hydrolase in, 291seminal vesicles, uptake of nonutiizable sugars

in vitro, 447studies on nonspecific blocking action of benzyl-

trimethylammonium bromide, 369vae deferens, inhibition of norepinephrine bio-

synthesis by chlorpromazine, 146

Halt, G., see Kypson, J., 398Haloperidol, effect on tryptophan concentration

in rat brain, 475Halothane

effects on hepatic drug metabolizing system,comparison with CC14, 556

procaine, pentobarbital and, effects on mam-malian myoneural junction, 360

Hancock, J. C., see Henderson, E. G., 377

668 INDEX

Hattori, K., see Shibata, S., 621Heart

dog, mechanism of positive inotropic and chron-otropic effects of angiotensin, 48

rat, glycogen content, effects of phenformin atsimulated high altitude, 276

rat, isolated, perfused with substrate-free me-dium, catecholamine stores, 96

slices, rabbit, sodium-dependent, opticallyspecific and reserpine-sensitive amine carriermechanism at adrenergic neuron, 389

Hemodynamics, effects of nitroglycerin and amylnitrite in conscious dog, 426

Hemoglobinderivatives, reactions with hydroxylarnine, 440

serum, effects of dimethyl sulfoxide in rabbits,520

Henderson, E. G. and Hancock, J. C. : Nicotine-induced depolarization and stimulation ofpotassium efflux in striated muscle, 377

Heroin, effect of dactinomycin on lethality inmice, 326

Hexamethonium

effect on acetaldehyde-induced catecholaminesecretion from cow adrenal medulla, 109

influence on negative chronotropic effect of

McNA-343,40Hexobarbital

metabolism, liver, role of corticosterone andsomatotropin in stress-mediated decrease, 227

metabolites, isolation and quantitation in mice,234

Hindpaw, dog, effects of prostaglandins E1, E,,F�, and F,,, on adrenergic vasoconstriction, 641

Histamineblocking action of benzyltrimethylammonium

bromide, 369effects on reserpine-treated rabbit aortic stripe,

127formation in mice, effect of decaborane, 177

kinetics, nonmast cell, interrelationship be-tween synthesis, binding and catabolism invivo, 579

norepinephrine, potassium and, contractions in

vascular smooth muscle, effects of lanthanum,415

HM-197 (5-benzoyloxy-2-iminohexahydropyrimi-dine hydrochloride), interference with excita-tion, 34

Hoch, F. L., see Petraitis, F. P., 514Holcomb, R., see Gerber, N., 234Holtzman, S. G. and Villarreal, J. E. : Pharmaco-

logic analysis of the hypothermic responses ofthe morphine-dependent rhesus monkey, 317

‘y-Hydroxybutyrate, effect on tryptophan concen-tration in rat brain, 475

Hydroxylamine, reactions with hemoglobin de-rivatives, 440

inbrain, rfa�on with anticonvulsant action of

inhibitors of carbonic anhydrase, 206in vivo formation in rabbit, 169

Hyperalgesia, morphine-induced, in rats testedon hot plate, 509

Hyperglycemia, carbohydrate metabolism after

treatment with 1-methyl-4-(3-methyl-5-isoxa-zolyl)pyridinium chloride and phenformin, 536

Hypertension, arterial, produced by barium, 433Hypokalemia, produced by barium, 433Hypotension, effect of renal pressor and sympa-

thetic nervous systems on vascular capacityduring, 56

Hypothermia, in morphine-dependent rhesus mon-

keys, 317

fleumguinea pig, blocking action of benzyltrimethyl-

ammonium bromide, 369rat and guinea pig, some effects of germine-3-

monoacetate, 181lodopyracet, renal effects in chimpanzee, 591

Isomers, optical, of pentazocine, analgesic activityand central nervous system distribution inrat, 500

Isoproterenol, effects on action potential repolari-zation in electrically driven guinea-pig atria,

85

Jewett, R. E., see King, C. D., 188Johnson, D. G., Thoa, N. B. and Kopin, I. J. : In-

hibition of norepinephrine biosynthesis bychlorpromazine in the guinea-pig vas deferens,146

Johnson, H. L. : Nonmast-cell histamine kinetics.IV. Interrelationship betweensynthesis, bind-

ing and catabolism of 8H-histamine in vivo, 579

Kadowitz, P. J., Sweet, C. S. and Brody, M. J.:Differential effects of prostaglandins E1, E1,F1,, and F2,, on adrenergic vasoconstriction in

the dog hindpaw, 641Kao, C. Y., see Spiegelstein, M. Y., 34Karim, A., Garden, G. and Trager, W. : Biotrans-

formation of diphenoxylate in rat and dog, 546Kayan, S., Woods, L. A. and Mitchell, C. L. : Mor-

phine-induced hyperalgesia in rats tested on

the hot plate, 509Kemp, J. W. and Woodbury, D. M. : Subcellular

distribution of 4.i4C�diphenylhydantomn in ratbrain, 342

Kent, K. M., see Dempsey, P. J., 78Khazan, N. and Colasanti, B. : Decline in the mean

integrated electroencephalogram voltage dur-ing morphine abstinence in the rat, 491

Kidneychimpanzee, effects of uricosuric agents, 591

INDEX 669

dog, release of pressor substances during hypo-

tension, 56function, direct and systemic effects of guaneth-

idine, 69hog and guinea pig, characterization of dipep-

tide hydrolase in, 291rat, pentazocine levels, 332

King, C. D. and Jewett, R. E. : The effects of a-methyltyrosine on sleep and brain norepineph-rine in cats, 188

Kininase II, angiotensin I converting enzyme, 291Kopin, I. J.

see Johnson, D. G., 146see Lemberger, L., 169

Kot, P. A., see O’Rourke, R. A., 426Kypson, J. and Halt, G. : The effects of ouabain,

calcium and potassium on the transport andincorporation of some amino acids into rabbit

atm! tissue in vitro, 398

Lactate, blood, rat, effects of phenformin at simu-lated high altitude, 276

Lactic dehydrogenase, serum, effects of dimethylsulfoxide in rabbits, 520

Landis, D. H., see Mass, J. W., 600Lanthanum, effects on “Ca movements and on

contractions induced by norepinephrine, his-tamine and potassium in vascular smoothmuscle, 415

I�eff, A., see Whitnack, E., 409Lemberger, L., Axelrod, J. and Kopin, I. J. : The

disposition and metabolism of tryptamine andthe in vivo formation of 6-hydroxytryptaminein the rabbit, 169

Lens, rabbits, dimethyl sulfoxide-induced

changes, 528i-Leucine, transport and incorporation into rabbit

atrial tissue in vitro, 398Levin, Y., see Yang, H. Y. T., 291Levitt, B., see Raines, A., 350Lipolysis, rat, effects of cardiac glycosides, 284

Lithium, effect on tryptophan concentration in rat

brain, 475

Liverblood flow, effect on removal rate of oxyphen-

butazone in dog, 246drug metabolizing system, effects of halothane

and CC14, 556hexobarbital metabolism, role of corticosterone

and somatotropin in stress-mediated decrease,227

mouse, isolation and quantitation of metabolites

of hexobarbital, 234

mouse, maternal, effect of phenobarbital and

SKF 525A on cyclophosphamide levels, 256

rat and man, metabolism of ethynodiol diace-

tate, 468

rat, glycogen content, effects of phenforinin at

simulated high altitude, 276rat, pentazocine levels, 332

Loh, H. H., Shen, F.-H. and Way, E. L. : Effect ofdactinomycin on the acute toxicity and brainuptake of morphine, 326

Long, J. P.see Dretchen, K., 369see Greenberg, S., 136

Lung, hog, characterization of dipeptide hydrolasein, 291

Lynn, R., see Gerber, N., 234Lysergic acid diethylamide, mescaline and, effect

On ificker discrimination in rat, 461

Mass, J. W. and Landis, D. H. : The metabolism ofcirculating norepinephrine by human sub-

jects, 600Maines, J. E., III, see Williams, R. L., 69Malaria, effects of 4,4’-cliformamidodiphenyl-

sulfone and related compounds, 301Man

blood, reactions between hydroxylamine andhemoglobin derivatives, 440

liver, metabolism of ethynodiol diacetate, 468metabolism of circulating norepinephrine, 600urine, enzymatic reactions and, isolation of

metabolite of daunorubicin from, 573

Mawhinney, M. G. and Thomas, J. A.: Uptake ofnonutiizable sugars by guinea-pig seminal

vesicles in vitro, 447McCallum, Z. T., see Dempsey, P. J., 78McN A-343, nicotine and, negative chronotropic

effects in isolated guinea-pig atria, insensitiv-ity to blockade by tetrodotoxin, 40

MoNay, J. L., see Whitsett, T. L., 246Medulla

adrenal, bovine, tyrosine hydroxylase, subcellu-lar distribution and aggregation, 155

adrenal, cow, acetaldehyde-induced catechola-mine secretion, 109

adrenal, effect of colch.icine, ymca alkaloids and

deuterium oxide on role of microtubules in

catecholamine release, 102Membrane, nictitating, cat, interaction between

angiotensin and norepinephrine in vivo, 633Mescaline, lysergic acid diethylamide, effect on

flicker discrimination in rat, 461

Metabolism

carbohydrate, in normal and hyperglycemic

animals treated with 1-methyl-4.(3-methyl.5-

isoxazolyl)pyridinium chloride and phen-

formin, 536

disposition and, of tryptamine and in vivo forma-tion of 6-hydroxytryptamine in rabbit, 169

drug, microsomal, hepatic, effects of halothane

and CC14, 556

670 INDEX

effects of phenformin at simulated high altitude,276

hexobarbital, liver, role of corticosterone andsomatotropin in stress-mediated decrease, 227

of circulating norepinephrine by human sub-jects, 600

of daunorubicin by rat tissue preparations, 567of ethynodiol diacetate by rat and human liver,

468of hexobarbital in mice, isolation and quantita-

tion of its metabolites in vivo and in vitro, 234of histamine in nonmast cells, 579of pentazocine in rat, 332

Metabolite (a)of daunorubicin in rat, 567of daunorubicin (daunorubicinol), isolation

from human urine and enzymatic reactions,573

of dimethyl sulfoxide, lenticular changes inrabbits, 528

of diphenoxylate in rat and dog, 546of ethynodiol diacetate in rat and human, 468of hexobarbital metabolism in mice, isolation

and quantitation, 234urinary, of norepinephrine in human subjects,

600Methazolamide, anticonvulsant action, relation

with monoamines in brain, 206

Methylatropine, effects on hypothermic responsesin morphine-dependent rhesus monkey, 317

3-c-Methyl glucose, uptake mechanisms in guinea-.pig seminal vesicles, 447

1-Methyl - 4 - (3 -methyl - 5 - isoxazolyl)pyridiniumchloride, phenformin and, effect on carbohy-drate metabolism in normal and hyperglyce-mule animals, 536

a-Methyltyrosineeffects on sleep and brain norepinephrine in

cats, 188effect on tryptophan concentration in rat brain,

475a-Methyl-meta-tyrosine, effects on spontaneous

and caudate-induced electroencephalogramactivity and regional catecholamines in cat

brain, 481Mice

action of 4,4’-diformamidodiphenylsulfone andrelated compounds on Plasmodium berghei, 301

effect of p-chlorophenylalanine on opiate-in-duced running, analgesia, tolerance andphysical dependence in, 309

effect of dactinomycin on acute toxicity andbrain uptake of morphine, 326

effect of decaborane on histamine formation, 177effect of phenobarbital and SKF 525A on placen-

tal transfer, 256isolation and quantitation of metabolites of

hexobarbital in vivo and in vitro, 234

obese diabetic, metabolic effects of 1-methyl-4-(3-methyl-5-isoxazolyl)pyridinium chloride,

536relation between monoamines in brain and

anticonvulsant action of inhibitors of carbonic

anhydrase, 206Microsomes, hepatic, drug metabolism system,

effects of halothane and CC14, 556Mitchell, C. L., see Kayan, S., 509Mohammed, S., see Whitnack, E., 409Monkey, rhesus, morphine dependent, hypo-

thermic responses, 317

Monoamines, in brain, relation with anticonvul-sant action of inhibitors of carbonic anhy-

drase, 206Mori, J., see Shibata, S., 621Morphine

abstinence i�. rat, decline in electroencephalo-gram voltage, 491

acute toxicity and brain uptake, effect ofdactinomycin , 326

-dependent rhesus monkey, hypothermic re-sponses, 317

effect in guinea-pig and rat ileum, antagonismby germine-3-monoacetate, 181

effect on tryptophan concentration in rat brain,475

-induced hyperalgesia in rats tested on hot plate,

509Musacchio, J. M., see Wurzburger, R. J., 155Muscle

papillary, cat, dissociation of inotropic and

transmembrane action potential effects ofouabain, 78

sartorius, frog, effects of HM-197 on electricalproperties, 34

sartorius, frog, effect of nicotine on potassium

efflux, 377smooth, vascular, effects of lanthanum on “Ca

movements and on contractions induced bynorepinephrine, histamine and potassium, 415

striated, nicotine-induced depolarization andstimulation of potassium efflux, 377

Nalorpine

effect on morphine-induced hyperalgesia in rats,509

hypothermic response in morphine-dependentrhesus monkeys, 317

Narahashi, T., Frazier, D. T., Deguchi, T.,

Cleaves, C. A. and Ernau, M. C. : The activeform of pentobarbital in squid giant axons, 25

Neostigmine, hypotherm.ic response in morphine-dependent rhesus monkeys, 317

Nervestimulation, cardioaccelerator, in dogs, effect of

L-dopa on chronotropic responses to, 409sympathetic, stimulation, in dog hindpaw,

INDEX 671

effects of prostaglandins E1, E,, F1,, and F2,, onvasoconstrictor responses , 641

Nervous system

central, rat, distribution of optical isomers ofpentazocine, 500

sympathetic, renal pressor system and, effecton vascular capacity during hypotension, 56

Neuronadrenergic, blockers, antagonism of effects of

cocaine, norepinephrine and ionic stimulantson rat van deferens, 136

adrenergic, sodium-dependent, optically specificand reserpine-sensitive amine carrier mecha-nism at, 389

Nicotine-induced depolarization and stimulation of

potassium efflux in striated muscle, 377MeN A-343 and, negative chronotropic effects

in isolated guinea-pig atria, insensitivity to

blockade by tetrodotoxin, 40sensitivity of aortic strips from young and old

rabbits, 621Nictitating membrane, cat, interaction between

angiotensin and norepinephrine in vivo, 633Nitrite, comparison with hydroxylamine, 440Nitroglycerin, amyl nitrite and, hemodynamic

effects in conscious dog, 426Norepinephrine

biosynthesis in guinea-pig vas deferens, in-hibition by chlorpromazine, 146

bloodborne exogenous, interaction with angio-tensin on cat nictitating membrane in vivo, 633

brain, sleep and, in cats, effects of a-methyl-

tyrosine, 188chronotropic responses to, before and after L-

dopa, 409circulating, metabolism by human subjects, 600cocaine, ionic stimulants and, effects on rat vas

deferens, antagonism by adrenergic neuron

blockers and reserpine, 136

content of aortic strips from young and old

rabbits, 621

effects on action potential repolarization in

electrically driven guinea-pig atria, 85histamine, potassium and, contractions in

vascular smooth muscle, effects of lanthanum,

415

in blood vessels, concentration, binding, uptake

and depletion, 119

in brain, relation with anticonvulsant action ofinhibitors of carbonic anhydrase, 206

in cat brain, effects of a-methyl-meta-tyrosine,

481

in dog hindpaw, effects of prostaglandins E1, E,,F1,, and Fe,, Ofl vasoconstrictor responses, 641

-induced lipolysis in rat, effects of cardiac

glycosides, 284

stores, cardiac, effects of perfusion with sub-

strate-free medium, 96

3H-norepinephrine, entry into arterial wall, 613

Olson, R. E., see Dhalla, N. S., 96Opiate-induced running, analgesia, tolerance and

physical dependence in mice, effect of p-

chlorophenylalanine, 309O’Rourke, R. A., Bishop, V. S., Kot, P. A. and

Fernandez, J. P. : Hemodynamic effects ofnitroglycerin and amyl nitrite in the conscious

dog, 426Ouabain

calcium, potassium and, effects on transport andincorporation of amino acids into rabbit atrial

tissue in vitro, 398dissociation of cardiac inotropic and trans-

membrane action potential effects of, 78

effect on carotid sinus reflex mechanism, 650

effects on lipolysis in rats, 284Oxyphenbutazone, removal rate in dog, effect of

hepatic blood flow, 246

Palmquist, M. A., see Wood, D. C., 520, 528Papillary muscle, cat, dissociation of inotropic and

transmembrane action potential effects ofouabain, 78

Pappano, A. J. : Propranolol-insensitive effects of

epinephrine on action potential repolarizationin electrically driven atria of the guinea pig,

85Pappano, A. J. and Rembish, R. A. : Negative

chronotropic effects of MeN A-343 and nico-

tine in isolated guinea-pig atria: Insensitivityto blockade by tetrodotoxin, 40

Parker, R. B. and Waud, D. R. : Pharmacologicalestimation of drug-receptor dissociation con-stants. Statistical evaluation. I. Agonists, 1

Parker, R. B., see Waud, D. R., 13Pearson, J. E., see Williams, R. L., 69Pentazocine

biologic disposition in rat, 332

optical isomers, analgesic activity and centralnervous system distribution in rat, 500

Pentobarbitalactive form in squid giant axons, 25procaine, halothane and, effects on mammalian

myoneural junction, 360Perez-Cruet, J., see Tagliamonte, A., 475Petraitis, F. P. and loch, F. L. : The effect of some

sedating agents on calorigenesis and its re-spouses to 2,4-dinitrophenol and L-thyroxinein rats, 514

pH, effects on potency of pentobarbital in squidgiant axons, 25

Pheneizine, effect on tryptophan concentration inrat brain, 475

Phenformin

672 INDEX

metabolic effects at simulated high altitude, 2761-methyl-4 - (3-methyl -5-isoxazolyl)pyridinium

chloride and, effect on carbohydrate metabo-lism in normal and hyperglycemic animals, 536

Pheniprazine, effects on levels of tryptamine inrabbit tissue, 169

Phenmetrazine, effect on tryptophan concentra-tion in rat brain, 475

Phenobarbitalpretreatment, influence on effects of halothane

and CCI4 on hepatic drug metabolizingsystem, 556

SKF 525A and, effect on placental transfer ofcyclophosphamide in mice, 256

Phenothiazines, structure-activity relationship,219

Phenoxybenzamine, pretreatment , influence oneffects of guanethidine, 69

Phentolamineantagonism of effects of epinephrine in elec-

trically driven guinea-pig atria, 85effects on reserpine-treated rabbit aortic strips,

127Phenylephrine, effects on reserpine-treated rabbit

aortic strips, 127Phosphodiesterase activity, theophylline-inhib-

ited, in rats, effects of cardiac glycosides, 284Phrenic nerve-diaphragm preparation, rat, effects

of procaine, pentobarbital and halothane, 360Physical dependence, running, analgesia, toler-

ance and, opiate-induced, in mice, effect ofp-chlorophenylalanine, 309

Physostigmine, hypothermic response in mor-phine-dependent rhesus monkeys, 317

Placenta, transfer of cyclophosphamide in mice,effect of phenobarbital and SKF 525A, 256

Plasmahog and guinea pig, characterization of dipep-

tide hydrolase in, 291mouse, maternal, effect of phenobarbital and

SKF 525A on cyclophosphamide levels, 256

rat, levels of optical isomers of pentazocine, 500

Pk�sinodium berghei, action of 4,4’-diformamidodi-phenylsulfone and related compounds on, 301

Poisner, A. M. and Bernstein, J. : A possible role ofmicrotubules in catecholamine release from

the adrenal medulla: Effect of colchicine,

ymca alkaloids and deuterium oxide, 102

Potassium

efflux in striated muscle, nicotine-induced

depolarization and stimulation, 377

ion, responses of superfused rat van deferens,136

norepinephrine, histamine, and, contractions

in vascular smooth muscle, effects of lantha-num, 415

ouabain, calcium and, effects on transport and

incorporation of amino acids into rabbit

atrial tissue in vitro, 398Potassium chloride

blocking action of benzyltrimethylammoniumbromide, 369

effects on reserpine-treated rabbit aortic strips,127

Probenecid

effect on tryptophan concentration in rat brain,475

renal effects in chimpanzee, 591Procaine, pentobarbital, halothane and, effects

on mammalian myoneural junction, 360Propranolol

-insensitive effects of epinephrine on actionpotential repolarization in electrically driven

guinea-pig atria, 85responses of superfused rat vas deferens, 136

Prostaglandins E1, E,, F1,, and F,,,, effects onadrenergic vasoconstriction in dog hindpaw,641

Prostate gland, guinea pig, uptake of nonutiiz-

able sugars, 447Psychotropic amines, tricyclic, structure-activity

relationships, 219Psychotropic drugs

effects on dopamine synthesis in rat striatum,196

effect on tryptophan concentration in rat brain,475

Putney, J. W., Jr. and Borzelleca, J. F. : On themechanisms of ‘�C-salicylic acid distributionin rat submaxillary gland in vitro, 263

Quest, J. A. and Gillis, R. A. : Carotid sinus reflexchanges produced by digitalis, 650

Rabbit(s)aortic strips, reserpine-induced supersensi-

tivity, 127atrial tissue, effects of ouabain, calcium and

potassium on in vitro transport and incorpora-tion of amino acids, 398

dimethyl sulfoxide-lenticular changes, 528disposition and metabolism of tryptamine and

in vivo formation of 6-hydroxytryptamine in,169

effects of lanthanum on “Ca movements and oncontractions induced by norepinephrine,histamine and potassium in vascular smoothmuscle, 415

entry of H-norepinephrine into arterial wall,613

norepinephrine in blood vessels, 119sodium-dependent, optically specific and reser-

pine-sensitive amine carrier mechanism atadrenergic neuron, 389

toxicology of dimethyl sulfoxide, 520

INDEX 673

young and old, aortic strips, adrenergic innerva-

tion and cocaine-induced potentiation ofresponses, 621

Raines, A., Sohn, Y. J. and Levitt, B. : Spinalexcitatory and depressant effects of sodium

diphenylthiohydantoinate, 350

Rat(s)alloxan or streptozotocin treated, metabolic

effects of 1-methyl-4-(3-methyl-5-isoxazolyl)-pyridinium chloride, 536

analgesic activity and central nervous systemdistribution of optical isomers of pentazocine,

500biologic disposition of pentazocine, 332

biotransformation of diphenoxylate, 546brain, effect of psychotropic drugs on trypto-

phan concentration, 475brain, subcellular distribution of 4-’4C-di-

phenylhydantoin, 342comparison of effects of halothane and CCI4 on

hepatic drug metabolizing system, 556decline in electroencephalogram voltage during

morphine abstinence, 491effect of dactinomycin on acute toxicity and

brain uptake of morphine, 326effect of mescaline and lysergic acid diethyl-

amide on flicker discrimination, 461effects of procaine, pentobarbital and halothane

on mammalian myoneural junction, 360effect of sedating agents on calorigenic re-

spouses to 2,4-dinitrophenol and L-thyrOxlne,514

heart, isolated, perfused with substrate-freemedium, cateoholamine stores, 96

ileum, guinea pig and, some effects uf germine-3-monoacetate, 181

influence of cinanserin and pharmacologic agents

on experimental allergic encephalomyelitis,454

liver, metabolism of ethynodiol diacetate, 468

mechanism of antilipolytic effects of cardiac

glycosides, 284

metabolic effects of phenformin at simulated

high altitude, 276

morphine-induced hyperalgesia, 509nicotine-induced depolarization and stimula-

tion of potassium efflux in striated muscle, 377

nonmast-cell histamine kinetics, 579

norepinephrine in blood vessels, 119

relation between monoamines in brain and anti-convulsant action of inhibitors of carbonic

anhydrase, 206

role of corticosterone and somatotropin in

stress-mediated decrease in liver hexobarbital

metabolism, 227

striatum, effects of some psychotropic drugs on

dopamine synthesis in, 196

studies on nonspecific blocking action of benzyl-

trimethylammonium bromide, 369submaxillary gland, distribution of 14C-salicylic

acid in vitro, 263tissue preparations, daunorubicin metabolism,

567vas deferens, antagonism of effects of cocaine,

norepinephrine and ionic stimulants byadrenergic neuron blockers and reserpine, 136

Rauh, C. E., see Gray, W. D., 206Reagan, R. I., see Davis, D. C , 556Reilly, M. A., see Schayer, R. W., 177Reilly, S. S., see Fanelli, G. M., Jr., 591Reit, E., see Cervoni, P., 633Rembish, R. A., see Pappano, A. J., 40Reserpine

adrenergic neuron blockers and, antagonism of

effects of cocaine, norepinephrine and ionicstimulants on rat vas deferens, 136

effects on dopamine synthesis in rat striatum,196

effects on levels of tryptainine in rabbit tissue,169

effect on norepinephrine content of bloodvessels, 119

effect on tryptophan concentration in rat brain,475

-induced supersensitivity in rabbit aortic strips,

127

-sensitive, sodium-dependent and opticallyspecific amine carrier mechanism at adrenergicneuron, 389

Riggi, S. J., see Blickens, D. A., 536Rosenfeld, R., see Freudenthal, R. I., 467Roza, 0. and Berman, L. B. : The pathophysiology

of barium: Hypokalemic and cardiovascular

effects, 433

Sakurai, L., see Shibata, S., 621Salicylate, renal effects in chimpanzee, 591

14C-Salicylic acid, distribution in rat submaxillary

gland in vitro, 263Sartorius muscle

frog, effects of HM-197 on electrical properties,34

frog, effect of nicotine on potassium efflux, 377Schayer, R. W. and Reilly, M. A.: Effect of dee-

aborane on histamine formation in mice, 177Schechter, M. D. and Winter, .1. C. : Effect of

mescaline and lysergic acid diethylamide onflicker discrimination in the rat, 461

Schneider, F. H. : Acetaldehyde-induced catechol-amine secretion from the cow adrenal medulla,109

Schroeder, D. see Davis, D. C., 556Scriabine, A., see Goldman, W. J., 181Seminal vesicles, guinea pig, uptake of nonutiiza-

ble sugars in vitro, 447

674 INDEX

Serotonin, brain, lowered, effect on opiate-in-duced running, analgesia, tolerance and

physical dependence in mice, 309

Shellenberger, M. K. : Effects of a-methyl -meta-tyrosine on spontaneous and caudate-induced

electroencephalogram activity and regionalcatecholamines in the cat brain, 481

Shen, F.-H., see Loh, H. H., 326

Shibata, S., Hattori, K., Sakurai, I., Mori, J.and Fujiwara, M. : Adrenergic innervationand cocaine-induced potentiation of adrener-gic responses of aortic strips from young and

old rabbits, 621Shore, P. A., see Sugrue, M. F., 389Sinus, carotid, changes produced by digitalis, 650SKF 525A, phenobarbital and, effect on placental

transfer of cyclophosphamide in mice, 256Smith, R. P., see Cranston, R. D., 440Smooth muscle, vascular, effects of lanthanum on

“Ca movements and on contractions inducedby norepinephrine, histamine and potassium,

415Sodium-dependent, optically specific and reser-

pine-sensitive amine carrier mechanism at

adrenergic neuron, 389Sodium pentobarbital, calorigenic responses to

2,4-dinitrophenol and L-thyroxine in rats, 514

Sohn, Y. J., see Raines, A., 350Somatotropin, corticosterone and, role in stress-

mediated decrease in liver hexobarbital

metabolism, 227Spector, S., see Berkowitz, B. A., 119Spiegelstein, M. Y. and Kao, C. Y. : Interference

with excitation by 5-benzoyloxy-2-imino-hexahydropyrimidine hydrochloride, 34

Spinal cord, cat, effects of sodium diphenylthio-hydantoinate, 350

Spleen, rat, pentazocine levels, 332Squid, giant axons, active form of pentobarbital

in, 25Stern, S., see Tagliamonte, A., 475Stomach, mouse, effect of decaborane on histamine

formation, 177

Striated muscle, nicotine-induced depolarizationand stimulation of potassium efflux, 377

Striatum, rat, effects of some psychotropic drugson dopamine synthesis in, 196

Strophanthin-K, effects on lipolysis in rats, 284Submaxillary gland, rat, distribution of 14C..

salicylic acid in vitro, 263Sugars, nonutiizable, uptake by guinea-pig

seminal vesicles in vitro, 447Sugrue, M. F. and Shore, P. A. : Further evidence

for a sodium-dependent, optically specific andreserpine-sensitive amine carrier mechanismat the adrenergic neuron, 389

Sulakhe, P. V., see Dhalla, N. S., 96Sulfinpyrazone, renal effects in chimpanzee, 591

Sweet, C. S., see Kadowitz, P. J., 641Swine, plasma, lung and kidney, characterization

of dipeptide hydrolase in, 291Sympathetic nerve, stimulation, in dog hindpaw,

effects of prostaglandins E1, E,, F1,, and F,.,, onvasoconstrictor responses , 641

Sympathetic nervous system, renal pressor sys-

tern and, effect on vascular capacity duringhypotension, 56

Tagliamonte, A., Tagliamonte, P., Perez-Cruet,J., Stern, S. and Gessa, G. L. : Effect ofpsychotropic drugs on tryptophan concentra-

tion in the rat brain, 475Tagliamonte, P., see Tagliamonte, A., 475

Tarver, J. A., see Berkowitz, B. A., 119Taylor, J. and Green, R. D. : Analysis of reserpine-

induced supersensitivity in aortic strips of

rabbits, 127Tetrabenazine, effect on sodium-dependent, op-

tically specific and reserpine-sensitive aminecarrier mechanism in rabbit heart, 389

Tetracaine, effect on acetaldehyde-induced cate-cholamine secretion from cow adrenal me-

dulla, 109

Tetrodotoxin

blockade, insensitivity to, negative chrono-tropic effects of MeN A-343 and nicotine inisolated guinea-pig atria, 40

responses of superfused rat vas deferens, 136Theophylline-induced lipolysis in rat, effects of

cardiac glycosides, 284Thioproperazin, effects on dopamine synthesis in

rat striatum, 196

Thoa, N. B., see Johnson, D. G., 146Thomas, J. A., see Mawhinney, M. G., 447L-Thyroxlne, 2,4-dinitrophenol, calorigenic re-

sponses in rats, effect of sedating agents, 514Tissue

parenchyrnatous, in rat, pentazocine levels, 332preparation, rat, daunorubicin metabolism, 567

rabbit, levels of tryptarnine, 169

T#{246}r#{246}k,J. and Bevan, J. A.: Entry of 8H-norepineph-rine into the arterial wall, 613

Toxicology of dimethyl sulfoxide, 520

Trager, W. , see Karirn, A. , 546Triester, S., see Yu, D. H., 284Tryptamine, disposition and metabolism in rab-

bit, 169Tryptophan, concentration in rat brain, effect of

psychotropic drugs, 475

d-Tubocurarine, effect on nicotine-induced de-polarization and stimulation of potassium

efflux in striated muscle, 377Tyramine

effects on rat heart perfused with substrate-freemedium, 96

responses of superfused rat vas deferens , 136

INDEX 675

Zoxazolamine, renal effects in chimpanzee, 591

sensitivity of aortic strips from young and old

rabbits, 621Tyrosine, effects on doparnine synthesis in rat

striatum, 196l-Tyrosine , transport and incorporation into

rabbit atrial tissue in vitro, 398Tyrosine hydroxylase, adrenal, bovine, subcellular

distribution and aggregation, 155

Urethane, calorigenic responses to 2,4-dinitro-phenol and L-thyrOxlne in rats, 514

man, enzymatic reactions and, isolation ofmetabolite of daunorubicin from, 573

man, metabolites of norepinephrine in, 600mouse, maternal, effect of phenobarbital and

SKF 525A on cyclophosphamide levels, 256Uterus, rat, blocking action of benzyltrimethyl-

ammonium bromide, 369

Van deferensguinea pig, inhibition of norepinephrine bio-

synthesis by chlorpromazine, 146rat, isolated, superfused, antagonism of effects

of cocaine, norepinephrine and ionic stimu-lants by adrenergic neuron blockers and

reserpine, 136Vasopressin, interaction with norepinephrine on

cat nictitating membrane in vivo, 633Villarreal, J. E., see Holtzman, S. G., 317Vogh, B. P. and Gleason, L. N. : Action of 4,4’-

diformamidodiphenylsulfone (DFD) and re-

lated compounds on Plasmodium berghei, 301

Wall, M. E., see Freudenthal, R. I., 468Waud, D. R. and Parker, R. B. : Pharmacological

estimation of drug-receptor dissociationconstants. Statistical evaluation. II. Corn-petitive antagonists, 13

Waud, D. R., see Parker, R. B., 1Way, E. L.

see Berkowitz, B. A., 500see El-Mazati, A. M., 332see Loh, H. H., 326

Weber, F. S., see Wood, D. C., 520, 528

Wedeking, P. W., see Babington, R. G., 454Wei, E. and Wilson, J. T. : Stress-mediated de-

crease in liver hexobarbital metabolism: Therole of corticosterone and somatotropin, 227

Weiss, G. B., see Goodman, F. R., 415Weller, W. L., see Gerber, N., 234Whitnack, E., Leff, A., Mohammed, S. and Gaff-

ney, T. E. : The effect of L-dopa on chrono-tropic responses to cardioaccelerator nerve

stimulation in dogs, 409

Whitsett, T. L., Dayton, P. G. and McNay, J. L.:The effect of hepatic blood flow on the hepaticremoval rate of oxyphenbutazone in the dog,246

Williams, R. L., Manes, J. E., III and Pearson,J. E. : Direct and systemic effects of guanethi-dine on renal function, 69

Wilson, J. T., see Wei, E., 227Winter, J. C., see Schechter, M. D., 461Wirth, N. V., see Wood, D. C., 528Woodbury, D. M., see Kemp, J. W., 342Wood, D. C., Weber, F. S. and Palmquist, M. A.:

Continued studies in the toxicology of di-methyl sulfoxide (DM50), 520

Wood, D. C., Wirth, N. V., Weber, F. S. andPalmquist, M. A. : Mechanism considerationsof dimethyl sulfoxide (DMSO)-lenticularchanges in rabbits, 528

Woods, L. A., see Kayan, S., 509

Wurzburger, R. J. and Musacchio, J. M. : Sub-

cellular distribution and aggregation of bovine

adrenal tyrosine hydroxylase, 155

Yang, H. Y. T., Erd#{246}s,E. G. and Levin, Y.:Characterization of a dipeptide hydrolase(Kininase II : Angiotensin I convertingenzyme), 291

Yu, D. H., Triester, S. and Gluckman, M. I.:Mechanism of antiipolytic effects of cardiacglycosides, 284