INJECTABLE DERMAL FILLER - euromeda.bg

L I P A U G M E N TAT I O NWRINKLES SMOOTHENINGL I P A U G M E N TAT I O NWRINKLES SMOOTHENING

L C A P H A R M A C E U T I C A L

HYALUDERM®

FACIAL REJUVENATIONS o d i u m h y a l u r o n a t e

FACIAL REJUVENATIONI N J E C T A B L E D E R M A L F I L L E R

NaHANEW FORMULATION

PRODUCT ORIGIN

• HYALUDERM is an intradermal,viscoelastic, sterile, apyrogenic, transparentstructuring gel composed of geneticallyengineered sodium hyaluronate with ahigh molecular weight, in accordancewith the European Pharmacopeia. Noanimal protein is contained in HYALUDERM.

• HYALUDERM is a natural derivative ofhyaluronic acid found in the extracellularmatrix of various types of connective tissuein the human body, particularly the skin.The hyaluronic acid polymers (polysac-charides) are essential for the metabolismof skin and vital to its hydrationand elasticity.

COMPOSITION

Sodiumhyaluronate (FB)

Sodiumchloride

Water forinjection

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PRESENTATIONHYALUDERM comes in two concentrations of

sodium hyaluronate :- 2.0% for moderately deep wrinkles- 2.5% for more severe, longer and deeper wrinkles(below or equal to 2 mm)

HYALUDERM is used during intradermal proceduresfor lip augmentation.For the smoothing of wrinkles, HYALUDERM addsfullness to the wrinkle without spreading into thehypodermis. It immediately, easily and rapidlycorrects wrinkles and scars.HYALUDERM enhances the volume and contourof lips.

HYALUDERM®



L I P A U G M E N TAT I O NWRINKLES SMOOTHENING


INDICATIONSN

aHA

2.0

%

NaH

A 2

.5%

NaHA

MECHANISMOF ACTION

• HYALUDERM 2.0% is indicated for the treatment ofmoderate wrinkles and fine lines of the face and forthe enhancement of lips.

• HYALUDERM 2.5% is indicated for the treatment ofdeep wrinkles and folds of the face.

• HYALUDERM is specifically recommended for :• Smoothing wrinkles and folds- Infraorbital wrinkles- Perioral rhytides- Upper lip rhytides- Lower face- Crow’s feet - Marionette lines- Forehead lines- Glabellar lines- Nasolabial foldDeficient skin tissue should be supple and easilystretched for the defects to be observed.

• HYALUDERM 2.0% enhances the volume andcontour of the lips and cheeks.

• HYALUDERM is an intradermal, viscoelasticstructuring gel composed of geneticallyengineered sodium hyaluronate available ina single-use, luer lock, prefilled glass syringe :HYALUDERM 2.0% : 0.5 ml, 1.0 ml and 2.0 mlHYALUDERM 2.5% : 1.0 ml

HYALUDERM is sterilised by steam autoclavein an individual sterility protector.A single-use, sterile 30g intradermal injection needle is provided in an individualsterility protector.

Skin tests

are not

necessary

due to the

bio-

availability

of sodium

hyaluronate

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GHYALUDERM®





ADVANTAGESDoes not contain any

animal protein

NaHA

NaH

A

RESULTS

THE EPIDERMIS

THE DERMIS

THESUBCUTANEOUSTISSUE

• The rheological proper t ies ofHYALUDERM enable the intradermalanatomical space to be rapidlyreconstituted. HYALUDERM eliminatesfolds and reduces depressions in the skindue to wrinkles. T

HE

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EW

A

NT

I-

AG

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NG

W

EA

PO

N

ADVANTAGES100% bioavailableVery well-tolerated

• HYALUDERM is a solution of highviscosity for intradermal injection :

NO

N-C

ROSS

-LIN

KED

ADVANTAGESDoes not contain any

Chemical Agent or anyparticles in suspension

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Raw material : Sodium Hyaluronate. EuropeanPharmacopaeia Pharmaceutical Grade

Origin : Genetic engineering/Non-cross-linked

Perfectly clear and transparent

Sterile, apyrogenic and non-cytotoxicfor subcutaneous tissues

Physiological pH 7.2

Osmolarity : 360 mOs/kg

Sterile (autoclave / steam)

Dynamic viscosity at rest (25°C - 0.01 s-1) 100 000 mPa.s (NaHA 2.0%)170 000 mPa.s (NaHA 2.5%)

High molecular weight : 2 400 000 Daltons

High concentration : 2.0% NaHA (20 mg/mL)2.5% NaHA (25 mg/mL)

Volume per syringe : 0.5 mL ; 1.0 mL ; 2.0 mL

Storage : room temperature

NaH

A

RHEOLOGY AND BEAUTY• The innovative rheological propertiesof HYALUDERM provide excellent cosmeticresults and enable the intradermalanatomical space to be rapidlyreconstituted. HYALUDERM eliminatesfolds and reduces depressions in the skindue to wrinkles.To obtain an ideal degree of correction,one or several additional injections ofHYALUDERM may be necessary.Efficacy lasts 6 2 months. The treatmentcan be repeated according to needs.

• It is recommended that patients withvery damaged skin (over exposure tosunlight, smoking, medication or dieting)use HYALUDERM 2.5% as viscosupplementinjections to the intercellular spaces of thedeficient dermis.

Wrinkle smoothing implants Rheological comparison

10

100

1000

10000

100000

1000000

0,1 1 10 100 1000 10000

Shear rate (s-1)

Dyna

mic

vis

cosi

ty (m

Pa.s

)

RestylaneHylaformHyaluderm 2%Hyaluderm 2.5%

HYALUDERM®





ADVANTAGESEasy to inject due toadaptation viscosity(pseudoplasticity)

NaHA

+-

9, allée Prométhée - F - 28000 Chartres - France - Phone : (33) 02 37 33 39 30 - Fax : (33) 02 37 33 39 39l c a f i l e @ w a n a d o o . f rPublic limited company with capital of 185 164,57 € - R.C.S. : Chartres B 311 274 401 - N° VAT : FR 44 311 274 401 00042


1.0ml

The HYALUDERM range

BOX OF 6 SYRINGES

HYALUDERM 2.0% and HYALUDERM 2.5% - 1.0 ml1.0 ml sterile syringe with Needle 30 G

HYALUDERM 2.0% - 0.5 ml0.5 ml sterile syringe with Needle 30 G

HYALUDERM 2.0% - 2.0 ml2.0 ml sterile syringe with Needle 30 G

0.5ml

2.0ml

ISO90012000

Directive 93/42/CEE

ISO134852003

HYALUDERM Production

Reference HYALUDERM 2.0% RANGE Reference HYALUDERM 2.5% RANGE

VD112010 1.0 ml – box of 1 syringe VD112510 1.0 ml – box of 1 syringe

VD162010 1.0 ml – box of 6 syringes VD162510 1.0 ml – box of 6 syringes

VD112020 2.0 ml – box of 1 syringe

VD162020 2.0 ml – box of 6 syringes

VD112005 0.5 ml – box of 1 syringe

VD162005 0.5 ml – box of 6 syringes

BOX OF 1 SYRINGE

VD1

M03

3 05

0501

NaHA 2.0%

NaHA 2.5%

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INJECTABLE DERMAL FILLER - euromeda.bg