Upload
others
View
4
Download
0
Embed Size (px)
Citation preview
Innovation | Creativity | Convergence
Innovation, Creativity, and Convergence are Pride of Department of Biomedical Sciences at the Graduate School of KU College of Medicine
We nurture core biomedical scientists who contribute to treatment of human diseases and improvement of health at the center of the world’s biomedical education.
Department of Biomedical Sciences at KU (affiliated with College of Medicine) has walked steadfast
along the path of biomedical science in respect for life and love for humanity. As a cradle cultivating
sophisticated biomedical scientists, and as one of the world’s best biomedical research institute that
trains leading global biomedical scientists, we are heading at the heart of the world’s biomedical science.
CONTENTS
04 Featured Research
06 Faculty & Research Units Basic Researchers
Clinical Researchers
Core Facilities
10 Curriculum
12 Scholarships
13 Admission Guide
14 Contact Information
15 Campus Map
Appendix I
17 Faculty & Laboratories
Appendix II
64 Curriculum (Full List)
Prologue 02 03
Discovery of a Novel Sensory Receptor
Neuronal sensory receptors are key contact
points to the environment, initiating
decisions for avoidance or preference.
Electrophysiology shows:
· TMC-1 is a novel ion channel.
· TMC-1 mediates high level sodium-
induced excitation.
· TMC-1 recording techniques may provide
a drug-screening platform.
Behavioral neuroscience shows:
· Nociceptor neurons express TMC-1.
· TMC-1 is necessary for nociceptive
behaviors against harmful levels of
sodium.
Chatzigeorgiou et al., 2013, Nature 494:95
Circadian Basis of Mood Regulation
Circadian molecular clockworks in
midbrain dopamine (DA) neurons:
Key regulators of mood
Impaired REV-ERBα actions
in DA neurons:
· Mania-like behaviors in mice
· HyperDAergic state:
Increased DA synthesis & release
Cooperation of REV-ERBα & NURR1:
· Circadian expression of tyrosine
hydroxylase (TH), a rate-limiting
factor of DA biosynthesis
· Competitive and rhythmic binding
onto TH promoter
Chung et al., 2014, Cell 157:858
Hematogenous Metastasis of Ovarian Cancer
ErbB3-neuregulin 1 (NRG1) axis is a
dominant pathway responsible for
hematogenous omental metastasis.
Elevated levels of ErbB3 in ovarian
cancer cells and NRG1 in the
omentum allowed for tumor cell
localization and growth in the
omentum. Depletion of ErbB3 in
ovarian cancer impaired omental
metastasis.
→ Ovarian cancer metastasis whereby
ErbB3 plays a critical role in
hematogenous dissemination of
ovarian cancer to the omentum.
Pradeep et al., 2014, Cancer Cell, 26(1):77
Featured Research01
Evolutionary Mechanism for Neuropeptide and GPCR Gene Families The vertebrate gene family
expands their members
through an evolutionary
mechanism including:
· local gene duplications
· 2 rounds (2R) of whole
genome duplication
Neuropeptides and their
G-protein-coupled receptors
coevolve through mutual
interactions
Understanding this mechanism
allows
· Identifi cation of novel
neuropeptide members
· Prediction of new peptide-
orphan receptor pairs
Hwang et al., 2013, Mol Biol Evol 30:1119
Cross-talk between Brain and Adipose Tissue Vasculature Apoptosis of endothelium in
white adipose tissue (WAT)
decreases body weight and food
intake independent of
hypothalamic leptin signaling.
Inhibition of WAT angiogenesis
rapidly improves glucose tolerance
independent of weight loss or
reduction in food intake.
Metabolomic and transcriptomic
studies suggest
· a novel role of the WAT
vasculature in glucose regulation
and lipid metabolism
· the existence of a previously
unknown player for the Brain-
WAT vasculature axis
Kim et al., 2012, Diabetes 61: 2299
Reliability and Performance of Different Stent Designs
A comparative reliability and performance study
of different stent designs: → To improve the mechanical performance of
stents
Conducting reliability performance testing
· Foreshortening, recoil, radial force and fl exibility
Finite element method(FEM) simulation
· Material properties for elasto-plastic analysis
· Coeffi cients of elasticity’s ratio was set to 13.22
Gpa
· Coeffi cients of poisson’s ratio was set to 0.30
We found that our design which was created
by a collaborative team from seven universities,
performed better than the commercial stents
across all parameter of foreshortening, recoil,
radial force, and fl exibility.
Choi et al., 2013, Arti� cial Organs 37:4
Featured Researches 04 05
Basic ResearchersProfessor Laboratory E-mail / Website
CHOI, Hyuk Lab of Biomedical Engineering [email protected] / ibr.korea.ac.kr
GEUM, Dongho Lab of Stem Cell Biology [email protected]
HAN, Hee Chul Neuroscience Research Institute [email protected]
HWANG, Jong-Ik Lab of GPCR and Signal Transduction [email protected] / gpcr.or.kr
HWANG, Sun Wook Lab of Sensory Neuroscience [email protected]
KEE, Sun-Ho Lab of Cell Biology [email protected]
KIM, Dong-Hoon Lab of Metabolic Disease [email protected]
KIM, Hyeon Soo Lab of AMPK Signal Transduction [email protected]
KIM, Hyun Lab of Molecular & Behavioral Neurobiology [email protected] / braingene.com
KIM, Tae Woo Lab of Tumor-Immune Dynamics [email protected]
KIM, Won-Ki Lab of Neuroscience [email protected]
KIM, Yang In Lab of Circadian Rhythm and Hypertension [email protected]
LEE, Eun Il Lab of Environment & Healthy Longevity [email protected]
LEE, Kyung-Mi Lab of Global Immunology Research [email protected]
MIN, Bon Hong Lab of Molecular Pharmacology [email protected]
NA, Heung Sik Lab of Sensory Abnormalities; Pain and Itch [email protected]
OH, Jun Seo Lab of Matrix Biology [email protected]
PARK, Hae Chul Lab of Neurodevelopmental Genetics [email protected]
PARK, Yongdoo Lab of Cell and Tissue Engineering [email protected] / cte.korea.ac.kr
RHYU, Im Joo Lab of Brain Structure and Neural Network [email protected]
SEONG, Jae Young Lab of GPCR and Signal Transduction [email protected] / gpcr.or.kr
SHIN, Ok Sarah Lab of Infection and Immunity [email protected]
SON, Gi Hoon Lab of Molecular Networks and Neurobiology [email protected]
SONG, Hoseok Lab of Cancer Biology [email protected]
SONG, Jin Won Lab of Molecular Virology [email protected]
SUL, Dong Geun Lab of Biomedical Proteomics [email protected]
SUN, Woong Lab of Neural Development and Stem Cell Research [email protected]
YOON, Young Wook Department of Physiology [email protected]
Faculty & Research Units02
Clinical ResearchersProfessor Laboratory E-mail / Website
CHO, Jae-Gu Department of Otorhinolaryngology-Head and Neck Surgery [email protected]
CHOE, Jae Gol Department of Nuclear Medicine [email protected]
HAM, Byung-Joo Interdisciplinary Affective Neuroscience Lab [email protected]
HONG, Soon Cheol Lab of Placenta Stem Cells [email protected]
KIM, Aeree Department of Pathology [email protected]
KIM, Byung Soo Department of Medical Oncology and Hematology [email protected]
KIM, Dong-Sik Lab of HBP Surgery & Liver Transplantation [email protected]
KIM, Hyun Koo Lab of Image-guided Cancer Surgery [email protected]
KIM, Min Ja Lab of Infection and Immunity [email protected]
KIM, Woo Joo Department of Infectious Diseases [email protected]
KIM, Yeul Hong Cancer Research Institute [email protected]
LEE, Chang Kyu Department of Lab Medicine [email protected]
LEE, Heon-Jeong Lab of the Circadian Rhythm & Mood Disorders [email protected] / kuhjnv.wix.com/circadianrhythmmood
LEE, Heung Man The Upper Airway Research Institute (TUARI) [email protected] / tuari.korea.ac.kr
LEE, Suk Lab of Medical Physics [email protected]
LIM, Chae Seung Lab of Biomedical Engineering [email protected]
LIM, Do-Sun Lab of Cardiac Regeneration [email protected]
OH, Sang Cheul Lab of Gastrointestinal Cancer Biology [email protected]
PARK, Jong Woong Hand Surgery & Reconstructive Microsurgery [email protected]
PARK, Kyong Hwa Department of Medical Oncology and Hematology [email protected]
RHA, Seung-Woon Cardiovascular Intervention and Research Institute [email protected] / www.ciri.or.kr
SEO, Jae Hong Lab of Breast Cancer Targeting Drug [email protected]
SHIN, Chol Korean Genome and Epidemiology Study (KoGES) [email protected]
SHIN, Sang-Wan Lab of Dental Research [email protected] / www.icdr.kr
SON, Sang Wook Lab of Cell Signaling and Nanomedicine [email protected]
SONG, Hae Ryong Lab of Bone Defect/Disease Fusion-Therapy Center [email protected] / www.kumcbone.or.kr
SUH, Seung-Wo Department of Orthopedic Surgery [email protected]
YOO, Hye Jin Lab of Diabetes & Atherosclerosis [email protected]
YOON, Soo-Young Lab of Diagnostic Technology Development [email protected]
※ Please see Appendix I for more detailed information on faculty members and their laboratories.
Faculty & Research U
nits 06 07
Medical Science Research Center
Main Research Facility in the KU College of Medicine The KU Medical Science Research Center (MSRC) was established to provide the up-to-date research and
educational facilities to the biomedical researchers in the KU College of Medicine for securing the research
competitiveness through this basic sciences infra.
KU-MSRC has successfully achieved its goals through the procurement of research equipment and effi cient
operation of education and training programs.→ More information is also available at our website: http://msrc.korea.ac.kr/
Key Research Facilities of the KU-MSRC Microscopy Lab: Electron Microscope (EM), Confocal Microscope, Total internal refl ection fl uorescence
microscopy (TIRF), etc
Core Facility Lab: Providing key equipments required for advanced biomedical research
Lab for radioactive isotopic materials
Core Facilities
Laboratory Animal Research Center
Our Mission The primary task of the KUMC Laboratory Animal Research Center (KLARC) is to house and breed various
animal species and strains according to the needs of the scientists working at the KU College of Medicine.
KLARC also aims to provide an effi cient research environment, where researchers can carry out both in-vivo
and ex-vivo experiments at one-stop under clean condition.→ More information is available at our website: http://klarc.korea.ac.kr
TIRF Microscope (TIRF 3) Confocal Microscope (LSM 700) MicroCT (SKYSCAN)TEM (H-7500)
Integrated & Translational Research Program
Our Mission In cooperation with KLARC, KU Integrated & Translational Research Program (KU-ITRP) aims to promote
and support productive collaborations among basic and clinical scientists in the Korea University College of
Medicine.
Supporting: This program helps clinical scientists in KU to effi ciently achieve excellence in their research by
providing molecular and cellular biological technologies.
Mentoring: The program promotes more active collaborations between basic and clinical scientists linking
their idea and expertise to expand world-class leading biomedical sciences in KU.→ More information is available at the KLARC website: http://klarc.korea.ac.kr
KU Practical Anatomy Center
The Leading Anatomy Center & Research Institute in Korea The KU Practical Anatomy Center & Research Institute (KU-PARI) has been founded in 2012 to support
anatomical/surgical education as well as related researches.
KU-PARI offers distinctive hands-on programs to students, researchers and surgeons.→ More information is also available at our website: http://pari.korea.ac.kr
Key Labs in the KU-PARI Anatomy Lab for basic anatomy education and surgical training
Cadaver OP Lab for cadaver workshops and related research
Virtual Anatomy and Surgical Simulation Lab
Microsurgery Lab equipped by Zeiss surgical microscopes
“Toward Global Frontier of Creative Medical Research”
Faculty & Research U
nits 08 09
Curriculum03
Biomedical Science aims to protect humans
from diseases and supports well-being
of human life. To accomplish this goal,
biomedical science broadly covers basic
and applied research to understand
mechanisms of pathogenesis and to fi nd
novel methods for preventive, diagnostic,
and therapeutic treatment. Biomedical
science, in particular, is a typical fusion-
science, composed of many disciplines from
biology, pharmacology, physics, chemistry,
engineering, bioinformatics, nanosciences,
and social sciences. The importance of
biomedical science is increasing with social
demands. Accordingly need for experts is
expanding and specialized training systems
are becoming necessary to train leading
experts in the biomedical sciences.
The mission of the Department of
Biomedical Sciences in the Korea University
Graduate Program is to nurture future
leading biomedical researchers through
the provision of relevant, up-to-date
biomedical knowledge, the support of
student’s independent research activities,
and the facilitation of student-professor and
student-student collaboration.
Academic Goals
Code Course Syllabus
BMS
501
Human
Physiology
The objective of this course is to provide information on the mechanisms and physiological functions
of the human body.
BMS
503
Molecular and
Cell Biology
The objective of this course is to provide information on the mechanisms and physiological functions
of the human body.
BMS
504
Introduction to
Clinical Medicine
The objective of this course is to provide understanding of introductory level cell biology, molecular
biology, and biochemistry. This course will cover signal transduction and control mechanisms which are
involved in complex and combined cell states such as structure and function of cellular and biological
molecules, energy production, enzyme epidemiology, mechanism and control, structure and function
of cellular membranes, and structure, function and differentiation of cells. Also, this course will deal
with cellular compartmentalization, movement of macro-molecules, biogenesis of organelles, cell
differentiation, cell movement, and cell conjunction.
BMS
505 -508
Biomedical
Seminars
The aim of this course is to provide an introduction to clinical symptoms, diagnoses and therapies
for various diseases. Also, an objective of this course is to structurally understand diseases by
understanding their etiology.
BMS
509
Foundation of
Biomedical Research
This course introduces guidelines for safe laboratory procedures and ethics for research and laboratory
animals, which are the basis of good biomedical research work.
BMS
510
Advanced Molecular
and Cell Biology
The objective of this course is to study current important topics of molecular and cell biology.
BMS
511
Introduction to
Biomedical Engineering
The aim of this lecture is to learn about various technologies based on engineering for biomedical
research. In this lecture, major topics of biomedical engineering such as medical devices, artifi cial
organs, signal processing and tissue regeneration will be reviewed. Current research status and issues
will be discussed.
BMS
527
Human
Anatomy
The objective of this course is to provide understanding of structure-function relationships of cells,
tissues, and organs and to apply interpreted signs and symptoms in human diseases and injuries.
BMS
528
Omics Convergence
Biomedical Technology
The objective of this class is to understand the state-of-the-art technologies in the fi eld of biomedical
research with special emphasis on the Omics techniques.
BMS
529
Biomedical
Industry
The objective of this class is to provide basic knowledge on biomedical R&D and how to transfer
research fi ndings into industry application.
BMS
530
Introduction to
the Translational Medicine
The aim of this lecture is to learn about basic concepts comprising translational approaches from
views of medicine and basic sciences, and to introduce practical links between the two to accelerate
development of therapeutics.
BMS
531
Introduction to Molecular
and Cell Biology
The objective of this class is to understand the biological bases of cellular functions at a molecular level.
BMS
532
Introduction to human
structure and function
The objective of the class is to introduce the structure and function of the human body, including basic
concepts in human anatomy and physiology.
BMS
639
Medical
Physics
The objective of this course is to provide understanding of models of human body phenomena based
on physical knowledge. Studying physics provides understanding of the mechanisms of action of
medicine and related phenomena.
※ All courses and syllabuses are listed in Appendix II Core Courses
Curriculum 10 11
Tuition fee (waived)The Department of Biomedical Sciences in association with Korea University
Medical Center (KUMC) will provide a grant that equals the tuition fee.
Stipend (complemented)The policy of the department is to guarantee a minimum stipend as follows:
Integrated master and doctoral course: 800,000 KRW (800 USD) per month
for the fi rst 2 years and 1,000,000 KRW per month for the next 4 years
Doctoral course: 1,000,000 KRW per month for 4 years
※ Students have to contact their tentative supervisor before application to
confi rm his/her fi nancial support.
Scholarships04
Eligibility A: An applicant holding foreign citizenship whose parents are
foreign citizens (not Korean citizens).
B: An applicant who completed the entire 16-year education
from elementary school to university in foreign countries (not
Korea).
※ An applicant who would like to apply for the admission
application for foreign students must satisfy one of the
requirements above. An applicant who satisfies all of them is
considered to have the eligibility A. Different requirements will
demand different documents to verify eligibility. Please refer to
the following webpages for more details.
Application Deadline The end of September (Beginning in the following March)
The end of March (Beginning in September)
Requirements Please contact tentative supervisors before your application for
the specific requirements and information.
General information on the graduate programs in Korea
University (KU) is available from the following webpages:
In addition to general documentation, our department requires
following documents:
· A research proposal approved by the tentative supervisor in
the KU Department of Biomedical Sciences
· Two references from his/her current college supervisors
Admission Guide05
Graduate Schoolhttp://graduate2.korea.ac.kr/programs/programs01.jsp
Admissionshttp://graduate2.korea.ac.kr/admission/admission01.jsp
Scholarships / Adm
ission Guide 12 13
Contact Information06Department Offi ceName: KIM, Dong Soon / PARK, Gye Hwa
E-mail: [email protected] / [email protected]
TEL: +82-2-2286-1135, +82-2-2286-1087 FAX: +82-2-2286-1088
Webpage: http://kumcbk21.korea.ac.kr/
Korea University Admission Offi ceName: KIM, Jihyun
E-mail: [email protected]
TEL: +82-2-3290-1358 (English), +82-2-3290-1357 (Chinese)
Webpage: http://graduate2.korea.ac.kr/programs/programs01.jsp
Foreign Students’ Community (Dept of Biomedical Sciences)Name: Mohammed R. Shaker
Webpage: https://www.facebook.com/bk21Foreignstudents
Location
By Subway Line 6 Anam Station Exit 1By Bus 101, 101, 111, 144, 163, 1017, 7211, Seongbuk 04, 1222, 273, 1111
By Car 150m on Inchon-ro(street) and 20m to the rightKorea University College of Medicine Inchon-ro, Seongbuk-gu,Seoul 136-705,Korea
Tel 82-2-2286-1139 Fax 02-924-4958
A. Main Hall, College of Medicine 1st fl oor Laboratory Animal Research Center 2nd fl oor Yookwangsa Hall, Dean’s offi ce, Center for Teaching and Learning, Department of Academic Affairs for College of Medicine, Medical Academic & Student Affairs Team , Research Administrative Team, cafeteria 1, cafeteria 2 3rd fl oor Lecture room, Dean’s offi ce for graduate school of clinical dentistry, Gwanbo Lounge, Headquarter of Medical Center (President’s offi ce’, Hospital director’s offi ce, Head conference room) 4th fl oor Lecture room, Academic affairs department for graduate school of clinical dentistry, Academic affairs department for graduate school of public health, Dean’s offi ce for graduate school of public health, Lounge, Outdoor garden 5th fl oor Ca-daver OP Room, Anatomy Lab, Virtual Anatomy & Surgical Simulation Lab, Microsurgery Lab, Practical Anatomy Research Institute 6th fl oor Medical science research center (Anam), Faculty lab, Common equipment room, DNA bank (Depression center), Cancer Research Lab, Pharmacogenomic Research Center for Psychotropic Drug 7th fl oor Medical science research center, Anam research center, General Research Equipment Laboratory, Stem Cell Lab, BSL 3 Lab
B. Moonsook medical Science Hall 1st fl oor Lecture room, Club room, Conference room, Alumni offi ce, Donation offi ce 2nd fl oor Department of Pre-ventive Medicine 3rd fl oor Department of Biochemistry & Molecular Biology 4th fl oor Department of Pharmacology 5th fl oor Department of Anatomy 6th fl oor Department of Microbiology 7th fl oor Department of Physiology
C. Medical Hall 1 1st fl oor Administrative offi ce for Anam hospital, Cochrane offi ce 2nd fl oor KU-KIST graduate school, Fitness room, Club room 3rd fl oor Department of Biostatistics, Common research support offi ce, Microscope Room, Administrative offi ce for Medical Center 4th fl oor Department of Medical Humanities, Department of Parasitology, Lab, Lecture room 5th fl oor Department of Neural Sciences, Information data processing Lab, Department of Forensic Medicine, Department of Pathology, NFS local offi ce, Lecture room
D. Medical Library 1st fl oor Serials Room 2nd fl oor Seminar room, Electronic Information Room 3rd fl oor Monographs Room(Circulation/Cataloging), Reading room 1,2,3,4,5
Korea University Anam Hospital
KU
Seoul
AMain Hall,
College of Medicine
DMedical Library
BMoonsook
Medical Science Hall
CMedical Hall 1
Parking Lot
Entrance Anam Station
Campus Map 07Contact Inform
ation / Campus M
ap 14 15
Basic Research Units
Faculty & Laboratories01Appendix
Professor Laboratory
CHOI, Hyuk Lab of Biomedical Engineering
GEUM, Dongho Lab of Stem Cell Biology
HAN, Hee Chul Neuroscience Research Institute
HWANG, Jong-Ik Lab of GPCR and Signal Transduction
HWANG, Sun Wook Lab of Sensory Neuroscience
KEE, Sun-Ho Lab of Cell Biology
KIM, Dong-Hoon Lab of Metabolic Disease
KIM, Hyeon Soo Lab of AMPK Signal Transduction
KIM, Hyun Lab of Molecular & Behavioral Neurobiology
KIM, Tae Woo Lab of Tumor-Immune Dynamics
KIM, Won-Ki Lab of Neuroscience
KIM, Yang In Lab of Circadian Rhythm and Hypertension
LEE, Eun Il Lab of Environment & Healthy Longevity
LEE, Kyung-Mi Lab of Global Immunology Research
MIN, Bon Hong Lab of Molecular Pharmacology
NA, Heung Sik Lab of Sensory Abnormalities; Pain and Itch
OH, Jun Seo Lab of Matrix Biology
PARK, Hae Chul Lab of Neurodevelopmental Genetics
PARK, Yongdoo Lab of Cell and Tissue Engineering
RHYU, Im Joo Lab of Brain Structure and Neural Network
SEONG, Jae Young Lab of GPCR and Signal Transduction
SHIN, Ok Sarah Lab of Infection and Immunity
SON, Gi Hoon Lab of Molecular Networks and Neurobiology
SONG, Hoseok Lab of Cancer Biology
SONG, Jin Won Lab of Molecular Virology
SUL, Dong Geun Lab of Biomedical Proteomics
SUN, Woong Lab of Neural Development and Stem Cell Research
YOON, Young Wook Department of Physiology
Appendix 01 Faculty &
Laboratories 16 17
Lab of Biomedical Engineering
PI: Hyuk CHOI, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2626 3302 (Offi ce) / +82 2 2626 2420 (Lab) Website: http://ibr.korea.ac.kr
Professor Choi is interested in and recognized the needs of convergence of medicine, engineering, and life science. Var-ious convergence studies are lively being researched. Most of all, organ chip development using MEMS technology and application of this research to observe traction force between intervertebral disc cells is being studied. Also, micro fl uidics based cell mechanism through CFD simulation, rehabilitation robot development of senior patients, and reliability and performance evaluation of medical devices are actively being studied.
Convergence Medical Device and Robot DevelopmentGOAL
1 H.Choi et al (2014) Integration of microfl uidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration. J Biomed Mater Res A 102(4):1164-72.
2 H.Choi et al (2013) New computerized indices for quantitative evaluation of depression and asymmetry in patients with chest wall deformities. Artif Organs 37(8):712-8.
3 H.Choi et al (2013) Effect of biphasic electrical current stimulation on IL-1β-stimulated annulus fi brosus cells using in vitro microcurrent generating chamber system. Spine (Phila Pa 1976) 38(22):E1368-76.
4 H.Choi et al (2013) A comparative reliability and performance study of different stent designs in terms of mechanical properties: foreshortening, recoil, radial force, and fl exibility. Artif Organs 37(4):368-79.
5 H.Choi et al (2013) Reference values for nerve ultrasonography in the upper extremity. Muscle Nerve. 47(6):864-71.
Organ Chip Study Based on Micro Fluidics Traction Force Research Computational Fluidic Dynamics Cell kinetics analysis & molecular works
Development of Rehabilitation Robot & Devices Finite Element Analysis Hardware & Firmware development Software development
Research Interest
Reliability Evaluation of Medical Devices Life Data Analysis such as MTTF, RCA, and Hazard, etc. High Risk Devices SOP development
Featured Publications
Lab of Stem Cell Biology
PI: Dongho GEUM, Ph.D. Department of Biological Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 1091 (Offi ce) / +82 2 2286 1325 (Lab)
Professor Geum is interested in the function of adult neurogenesis on mood disorder. He uses genetically modifi ed mice to ablate neural stem cells in the adult brain, and examines the relationship between mood disorder and the fates of neu-ral stem cells, progenitors and mature neurons in the hippocampus. His research interest extends to bipolar disorder. He made iPS cells from bipolar disorder patients, and is now analyzing monoamine neurons differentiated from iPS cells and screening new drugs for bipolar disorder patients.
Molecular Mechanism of Depression and Bipolar DisorderGOAL
1 H. Lee et al (2013) Circadian rhythm hypothesis of mixed features, antidepressant treatment resistance and manic switching in bipolar disorder. Psychiatry Investig. 10(3):225-32.
2 Y. Park et al (2013) NonO binds to the CpG island of oct4 promoter and function as a transcriptional activator of oct4 gene expression. Mol Cells 35(1):61-9.
3 Y. Park et al (2011) Human feeder cells can support the undifferentiated growth of human and mouse embryonic stem cells using their own basic fi broblast growth facors. Stem Cells Dev. 20(11): 1901-10.
4 M. Hwang et al (2008) The neuronal differentiation potential of Ldb1-null mutant embryonic stem cells is dependent on extrinsic infl uences. Stem Cells 26(6):1490-5.
5 G. Son et al (2006) Maternal stress produces learning defi cits with impairment of NMDA receptor mediated synaptic plas-ticity. J. Neurosci. 26(12):3309-18.
Adult neurogenesis and mood disorder
Research Interest
Generarion of Bipolar disorder patients’ iPS cells and analyzing dopaminergic neurons differentiatiod for m iPS cells
Featured Publications
Appendix 01 Faculty &
Laboratories 18 19
Lab of GPCR and Signal Transduction
PI: Jong-Ik HWANG, Ph.D. DVM Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 1093 (Offi ce) / +82 2 2286 1092 (Lab) Homepage: http://gpcr.or.kr
JIH is interested in mechanisms underlying infl ammatory processes which are deeply related to various patho-physiolog-ical conditions, such as cancer, fi brotic organ failure, and transplantation. Particularly, G-protein coupled receptors (GP-CRs)-related signal transduction and NF-kB activation machineries are his main research topics. Using molecular and bio-chemical tools he is investigating molecular interaction of signaling proteins and the functional meaning of the interaction in terms of cellular responses. He is also interested in development of animal models of cancer progression and fi brosis.
Validation of therapeutic targets in infl ammation and cancersGOAL
1 You et al. (2014) A Splicing Variant of NME1 Negatively Regulates NF-kB Signaling and Inhibits Cancer Metastasis by Interacting with IKKb. J. Biol. Chem. 289: 17709.
2 Park et al. (2014) Apoptotic Death of Prostate Cancer Cells by a Gonadotropin-Releasing Hormone-II Antagonist. Plos ONE 9:e99723.
3 Hwang et al. (2013) Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplica-tions before and after two rounds of whole genome duplication. Mol Biol Evol 30:1119.
4 Hurh et al. (2013) Expression Analysis of Combinatorial Genes Using a Bi-Cistronic T2A Expression System in Porcine Fibroblasts. Plos ONE 8:e70486
5 Kim et al. (2011) Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation. Cell. Signal. 22:1645
Research Interest
Featured Publications
Lab of Sensory Neuroscience
PI: Sun Wook HWANG, Ph.D. Depts of Biomedical Sciences & Physiology
Contact Information E-mail: [email protected] Tel: +82 2 2286 1231 (Offi ce) / +82 2 2286 1204 (Lab)
Senses including touch and pain are the ways we feel the internal and external environment. SWH is studying the sensory mechanisms in the context of neurobiology. Particularly, he is focusing on the identities and functions of interface molecules located in the nerves and skin, transducing environmental changes into neural signals that eventually arrive at the brain. He is also trying to fi nd chemical modulators for these sensory molecules that may modify our sensation or alleviate pain.
Exploring sensory mechanisms and developing their chemical modulatorsGOAL
1 Chiu et al. (2013) Bacteria activate sensory neurons that modulate pain and infl ammation. Nature 501:52
2 Chatzigeorgiou et al. (2013) tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Nature 494:95
3 Bang et al. (2012) Nociceptive and pro‐infl ammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. Br J Phar-macol 166:1433
4 Chatzigeorgiou et al. (2010) Specifi c roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat neurosci 13:861
5 Bang et al. (2010) Farnesyl pyrophosphate is a novel pain-producing molecule via specifi c activation of TRPV3. J Biol Chem 285:19362
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 20 21
Lab of Metabolic Disease
PI: Dong-Hoon KIM, M.D., Ph.D. Department of Pharmacology and Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 1237 (Offi ce) / +82 2 2286 1236 (Lab)
DHK is interested in the interaction between CNS and periphery in the control of food intake and glucose related to adi-pose tissue vasculature. He is studying “previously unknown” crosstalk between the status of adipose tissue vasculature and CNS. He is also focusing on identifying the role of new players in the regulation of energy andglucose homeostasis.
Identifi cation of Novel Players for Metabolic DiseaseGOAL
1 Kim et al. (2013) Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase. Am J Physiol Regul Integr Comp Physiol 305(5):R499.
2 Kim et al. (2013) Metformin decreases meal size and number and increases c-Fos expression in the nucleus tractus sol-itarius of obese mice. Physiol Behav 17;110-111:213.
3 Kim et al. (2013) Increased adipose tissue hypoxia and capacity for angiogenesis and infl ammation in young diet-sensi-tive C57 mice compared with diet-resistant FVB mice. Int J Obes 37(6):853.
4 Kim et al. (2012) Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes 61(9):2299.
5 Kim et al. (2010) Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight. Diabetes 59(4):907.
Research Interest
Featured Publications
Discovery of Novel Adipokines
Discovery of Predictors for Obesity and Diabetes
Mechanisms underlying the Benefi cial Effects of Bariatric Surgery
Role of Novel Player in Energy and Glucose Homeostasis
Brain-WAT Vasculature Axis
Kim et al., Diabetes 2010; Kim et al., Diabetes 2012
Molecular & Metabolic Phenotyping Approaches
Lab of AMPK Signal Transduction
PI: Hyeon Soo KIM, M.D & Ph.D. Department of Anatomy
Contact Information E-mail: [email protected] Tel: +82 2 2286 1151 (Offi ce) / Fax: +82 2929 5696
His research topic is AMPK, particularly in diabetes and cancer. His research aim is searching for new AMPK activator, inter-acting protein and substrate. His aim is to understand diabetes and cancer in the molecular level. Now, he identifi ed several novel AMPK activators, binding proteins, and substrates and characterizing its signal network analysis in vitro. His conclusive goal is to provide molecular candidate for the development of treatment dug for diabetes and cancer.
Molecular understanding of diabetes and cancerGOAL
1 Kim et al. (2014) AMPKα2 translocates into the nucleus and interacts with hnRNP H: Implications in metformin-medi-ated glucose uptake. Cell Signal 26:1800-6.
2 Lee et al. (2013) E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal mus-cle C2C12 cells. J Biol Chem 288: 4673-80.
3 Lee et al. (2012) Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activated protein ki-nase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells. J Biol Chem 287: 44121-9.
4 Kim et al. (2011) The glutamate agonist homocysteine sulfi nic acid stimulates glucose uptake through the calcium-de-pendent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells. J Bio Chem 286:7567-76.
5 Lee et al. (2008) Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells. J Bio Chem 283:33969-74.
Research Interest
Featured Publications
Role of AMPK regulator Novel AMPK activator In vitro glucose uptake Insulin s ensitizing effect
Novel nuclear role of AMPK Nuclear translocation Target gene Mutagenesis
novel substrate of AMPK 2-D + phospho staining MALDI-TOF/Blast search AMPK consensus motif
Appendix 01 Faculty &
Laboratories 22 23
Lab of Molecular & Behavioral Neurobiology
PI: Hyun KIM, M.D., Ph.D. Department of Anatomy & Neuroscience
Contact Information E-mail: [email protected] Tel: +82 2 2286 1153 (Offi ce) / +82 2 2286 1384 (Lab) Homepage: http://braingene.com
HK’s main research interests are in molecular and neural mechanisms underlying synaptic plasticity and psychiatric disor-ders. More specifi cally, he has focused on the neural activity-dependent protein in synapse and its physiological function. He is also trying to reveal depression-related genes in habenula and to implicate them to treatment of depressive disorder.
Understanding the Molecular and Neural Basis of Brain Function and DiseaseGOAL
1 Han et al. (2014) Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice. Mol Cells. 37(1):24-30.
2 Lee et al. (2013) MDGAs selectively interact with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. PNAS. 110(1): 336-341.
3 Mo et al. (2012) Preso regulation of dendritic outgrowth through PI(4,5)P2–dependent PDZ interaction betaPix. Eur. J. Neurosci. 36: 1960–1970.
4 Lee et al. (2012) Inositol 1,4,5 trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phos-phoregulation of microtubule binding affi nity. J Biol Chem. 287(19):15981-15995.
5 Kim et al. (2009) Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. J Neurosci. 29(44):14039-14049.
Research Interest
Featured Publications
Lab of Tumor-Immune Dynamics
PI: Tae Woo KIM, Ph.D. Depts. of Biomedical Sciences & Biochemistry
Contact Information E-mail: [email protected] Tel: +82 2 2286 1305 (Offi ce) / +82 2 2286 1301 (Lab.)
We are trying to understand tumor-immune dynamics to overcome immune resistance of tumors. Recent research clearly demonstrate that the immune system plays a fundamental role in combating tumors. However, fundamental questions how tumors acquire intrinsic and acquired resistance to immune-cell killing remain. Therefore, we aim to elucidate the multidimensional, nonlinear nature of the interaction between immune and tumor to realize the ideal goal of cancer immunotherapy.
Understanding of Tumor-Immune Dynamics for Better Cancer ImmunotherapyGOAL
1 Kim et al. (2003) Enhancing DNA Vaccine Potency by Co-Administration of DNA Encoding Anti-Apoptotic Proteins, J. Clin. Invest., 112(1):109.
2 Kang et al. (2010) Ectopic Expression of X-linked Lymphocyte-Regulated Protein pM1 (XLR) Renders Tumor Cells Resis-tant to Anti-Tumor Immunity, Cancer Res. 70(8):3062.
3 Noh et al. (2012) Cancer vaccination drives Nanog-dependent evolution of tumor cells towards an immune-resistant and stem-like phenotype, Cancer Res. 72(7):1717.
4 Noh et al. (2012) Nanog signaling in cancer promotes stem-like phenotype and immune evasion, J Clin Invest. 122(11):4077.
5 Noh et al. (2014) API5 confers tumor immune resistance through an FGF2/FGFR1/PKCδ-dependent cell survival pathway, (In press, Cancer Research).
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 24 25
Lab of Neuroscience
PI: Won-Ki KIM, Ph.D. Department of Neuroscience Director, Research Institute for Infl ammation Control
Contact Information E-mail: [email protected] Tel: +82 2 920 6094 (Offi ce) / +82 2 2286 1095,6 (Lab)
The study goal of our laboratory is to elucidate the cell death cascades in cerebral ischemia and to discover and develop novel neuroprotectants. We study the effi cacy and mechanism of action of the protectants in in vivo and in vitro exper-imental models. Additionally, we actively collaborate with pharmaceutical companies to evaluate the pharmacokinetic properties and toxicological activities of the drug candidates.
Drug Development for Ischemic Stroke TherapyGOAL
1 Kim C, Yun N, Lee YM, Jeong JY, Baek JY, Song HY, Ju C, Youdim MB, Jin BK, Oh YJ, Kim WK, Gel-based protease proteom-ics for identifying the novel calpain substrates in dopaminergic neuronal cell. J. Biol. Chem. 2013 Dec 20;288(51):36717-32
2 Choi et al (2013) Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury. Am. J. Pathol. 182(3):928-39
3 Cho et al. (2013) N-Methyl-D-aspartate receptor antagonists memantine and MK-801 attenuate the cerebral infarct ac-celerated by intracorpus callosum injection of lipopolysaccharides. Neurosci. lett. 538:9-14
4 Ju et al (2013) Up-regulation of astroglial heme oxygenase-1 by a synthetic (S)-verbenone derivative LMT-335 ameliorates oxygen-glucose deprivation-evoked injury in cortical neurons. Biochem. Biophy. Res. Comm. 431(3):484-9
5 Choi et al (2011) A3 adenosine receptor agonist reduces brain ischemic injury and inhibits infl ammatory cell migration in rats. Am. J. Pathol. 179(4):2042-52
Research Interest
Featured Publications
Animal Ischemic Stroke Model Life Data Analysis such as MTTF, RCA, and Hazard, etc. High Risk Devices SOP development
Cell Culture System Neuron, glia primary culture. Treatment: Oxygen glucose deprivation/Reperfusion, NMDA, Cytokine, LPS etc.
Assay: Cell viability, Ca2+ infl ux, Cell migration, Cytokine, ROS, NO, etc.
Lab of Environment & Healthy Longevity
PI: Eunil LEE, M.D., Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 6117 (Offi ce) / +82 2 2286 1348 (Lab)
Professor Lee is interested in novel environmental effects to human health. Main research topics are to evaluate the healthy longevity mechanisms under pressure environment and short & long term effects by light at night (LAN) environ-ment, and to estimate chronic diseases effects by weather conditions including climate change.
Promotion of Human Health by Environmental Modifi cationGOAL
1 S.Lee et al (2014) Short-term effect of temperature on daily emergency visits for acute myocardial infarction with thresh-old temperatures. PLoS ONE 9(4):e94070
2 E.Hong et al (2012) Tissue-specifi c and age-depedent expresssion of protein arginine methyltransferases (PRMTs) in male rat tissue. Biogerontology 13(3) 329
3 S.Oh et al (2010) Elevated pressure, an novel cancer therapeutic tool for sensitizing cislatin-mediated apotptosis in A549. BBRC 399: 91
4 S.Oh et al (2010) Role of elevated pressure in TRAIL-induced apoptosis in human lung carcinoma cells. Apoptosis 15(12):1517
5 Y.Lim et al (2010) Proteomic identifi cation and comparative analysis of asymmetrically arginine-methylated proteins in immortalized, young and senescent cells. Electrophoresis 31: 3823
Research Interest
Featured Publications
Research of the regulatory mechanisms by pressure Healthy longevity Cellular i ntegrity Epigenetic c hange
Development of Health Risk Assess-ment Technology and System of Light Pollution Human health risk assessment for Light pollution Light pollution related biomarkers discover-ing and development
Health Effects by Climate Change Time series analysis to evaluate(estimate) health effects Use of the various climate indices with GIS mapping
Appendix 01 Faculty &
Laboratories 26 27
Lab of Global Immunology Research
PI: Kyung-Mi LEE, Ph.D. Department of Biochemistry
Contact Information E-mail: [email protected] Tel: +82 920 6253 (Offi ce) / +82 920 6251 (Lab)
Tumor Immunotherapy employing NK and T cells Converging Biomedical Engineering with Cell Therapy Stem Cell Therapy for Knee regeneration Development of Cell-based combination therapies for resistant tumors Understanding Allergies/Infection/Autoimmune Diseases utilizing gene-defi cient mouse models, 2B4, CD160, BTLA, Light, HVEM..
To develop novel therapies of cancer and immune-related diseases by investigating the basis of immune dysregulation
GOAL
1 Seon Ah Lim, Tae-Jin Kim, Jung Eun Lee, et al.(2013) Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res. (IF 8.65)
2 Kim et al. (2014) Innate Lympoid cells control NK cell development through lymphotoxin mediated control of the stromal microenvironment. J Exp Med. (IF 13.214)
3 Kyung Hee Noh, Seok-Ho Kim, Jin Hee Kim, et al.(2014) API5 Confers Tumoral Immune Escape through FGF2-Dependent Cell Survival Pathway. Cancer Res. (IF 8.65)
4 Hwang et al. (2014) Dissolution Chemistry and Biocompatibility of Single-Crystalline Silicon Nanomembranes and Associ-ated Materials for Transient Electronics. ACS Nano. (IF 12.062)
5 Hwang et al. (2014) Materials for high performance biodegradable semiconductor devices. Advanced materials. (IF 14.829)
Research Interest
Featured Publications
Applying Biomedical Engineering tools into Cancer Immunotherapy
Cell-Based Combination Therapies for Resistant Tumors
NK cells and T cells for Cancer Immunotherapy
Lab of Molecular Pharmacology
PI: Bon Hong MIN, Ph.D. Department of Pharmacology
Contact Information E-mail: [email protected] Tel: +82 2 2286 1128 (Offi ce) / +82 2 2286 1401(Lab)
BHM’s research interest is to understand molecular mechanisms underlying cancer cell metastasis and chemo-resistance of clusterin that has been shown to be a stress-activated, antioxidant, and cytoprotective chaperone protein. We also investi-gate the role of clusterin as a modulator of microenvironment in cancer metastasis, infl ammation, and tissue regeneration processes. Presently, we reported that clusterin induces chemotatic migration of macrophages and regulates MMP-9 and TNF-a secretion via GPCR/TLR4 signal for ECM modulation and infl ammatory processes in microenvironment of tumor tissues using cell culture system and purifi ed clusterin protein. To further confi rm the roles of clusterin in vivo, we are now generating clusterin knock-in transgenic mice for tissue specifi c expression using Cre-lox system in ROSA-26 locus.
1 1. Kang et al. (2014) Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and Gβγ-dependent pathways. BBRC 445(3):645.
2 Kwon et al. (2014) Defi ciency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology 155(6):2089.
3 Shim et al. (2012) Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages. BBRC 422(1):200
4 Lee et al. (2012) Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster. BBRC 420(4):851.
5 Shim et al. (2011) Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages. J. Leukoc. Biol. 90(4):761.
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 28 29
Lab of Sensory Abnormalities; Pain and Itch
PI: Heung Sik NA, M.D., Ph.D. Department of Physiology
Contact Information E-mail: [email protected] Tel: +82 2 2286 1188 (Offi ce) / +82 2 2286 1202 (Lab)
Pain and itch are unpleasant sensations, accompanied with the withdrawal and scratching refl exes, respectively, which help us avoid harmful stimuli. However, these warning bells might comprise remarkably the quality of your life when they become chronic condition. We are interested in chronic pain and itch, particularly nerve injury-induced pain, called neuro-pathic pain and incessant itch in atopic dermatitis, and looking for the cellular or molecular basis for these chronic neural diseases using our own animal models.
1 Jeong et al. (2014) Juvenile obesity aggravates disease severity in a rat model of atopic dermatitis. AAIR (in press).
2 Back et al. (2012) Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis. J Dermatol Sci 67:111.
3 Kim et al. (2012) TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord. Neuron 74:640.
4 Back et al. (2006) Loss of spinal μ-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy. Pain 123:117.
5 Na et al. (1994) A behavioral model for peripheral neuropathy produced in rat’s tail by inferior caudal trunk injury. Neu-rosci Lett 177:50.
Research Interest
Featured Publications
Neuropathic pain Behavioral studies with several animal models Molecular and cellular mechanisms of central sensitization Pharmacological intervention
Chronic itch in atopic dermatitis Cross-talking mechanisms among keratino-cytes, immune cells and nerves in the skin
Development of novel analgesics and antipruritics Digging out the target molecules and development of new drug candidates Collaboration with domestic drug manufac-turers Omega conotoxins, Patent No: US08673856 (2014.03.18) Benzoxazole derivatives for pruritus amelio-ration, Application No: 10-2014-0011372 (2014.01.29)
Lab of Matrix Biology
PI: Junseo OH, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 1389 (Offi ce) / +82 2 2286 1396 (Lab)
Our laboratory has focused on two research area; fi brosis and cancer biology. Over the last three decades, much efforts have been paid to elucidate the molecular mechanism for the development of tissue fi brosis and develop the effective an-ti-fi brotic drug. Unfortunately, there is no appropriate therapy available at present. Cancer is likewise one of the obstinate diseases. We have previously demonstrated a novel role of albumin in hepatic stellate cells and proposed a recombinant fusion protein of albumin-RBP as a potential anti-fi brotic drug.
Development of anti-fi brotic therapyGOAL
1 Park S et al (2012) Retinol binding protein-albumin domain III fusion protein deactivates hepatic stellate cells. Mol Cells. 34(6), 517-22.2.
2 Choi S et al (2012) Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells. Biochem. Biophys. Res. Commun. 418(1), 191-7.
3 Erkan M et al (2012) StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 61(2), 172-8.
4 Kim N et al (2010) Albumin mediates PPAR-g and C/EBP-a -induced phenotypic changes in pancreatic stellate cells. Bio-chem. Biophys. Res. Commun. 391(1), 640-644.
5 Kim N et al (2009) Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin. Gut 58(10), 1382-90.
Research Interest
Featured Publications
Albumin inactivated stellate cells Construction of retinol-binding protein (RBP)-albumin fusion protein
RBP-albumin fusion protein reduces liver fi brosis
Appendix 01 Faculty &
Laboratories 30 31
Lab of Neurodevelopmental Genetics
PI: Hae Chul PARK, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 31 412 6712 (Offi ce) / +82 31 412 6725 (Lab)
Professor HCP is interested in neural development and related diseases in the central nervous system. His research is focused on oligodendrocyte developemt and multiple sclerosis, motor neuron development and amyotrophic lateral scle-rosis, and novel neuropeptide screening and functional analysis. Zebrafi sh is one of the most famous vertebrate anmimal model and Prof. Park’s lab established techniques for the generation of KO zebrafi sh and transgenic zebrafi sh to study CNS development and diseases.
Understanding CNS diseases and underling mechanismsGOAL
1 Chung et al. (2013) Generation of demyelination models by targeted ablation of oligodendrocytes in the zebrafi sh CNS. Molecules and Cells 36, 82-87.
2 Chung et al. (2013) Indian hedgehog B function is required for the specifi cation of oligodendrocyte progenitor cells in the zebrafi sh CNS. Journal of Neuroscience 33(4), 1728-1733.
3 Kim S et al. (2012) Antagonistic regulation of PAF1C and pTEF-b is required for oligodendrocyte Differentiation. Journal of Neuroscience 32, 8201-8207.
4 Kim S et al. (2010) Visualization of myelination in GFP-transgenic zebrafi sh. Developmental Dynamics 239, 592-597.
5 Chung et al. (2010) Neuron-specifi c expression of atp6v0c2 in zebrafi sh CNS. Developmental Dynamics 239, 2501-2508.
Research Interest
Featured Publications
Lab of Cell and Tissue Engineering
PI: Yongdoo PARK Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: 82 2 2286 1458 Homepage: http://cte.korea.ac.kr
The aim of my research is to investigate the morphogenic tissue regeneration, which is closely linked to cellular behavior in 3D. Engineering cellular environments such as chemical or physical factors determines the major factors for tissue mor-phogenesis in regeneration and development
From cells to Tissues for morphogenic regenerationGOAL
1 M. Song et al. (2014) Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP. Biomaterials 35(8): 2436-2445
2 Hong et al. (2013) Cellular behavior in micropatterned hydrogels by bioprinting system depended on the cell types and cellular interaction. Journal of Bioscience and Bioengineering 116(2): 224-230
3 Kim et al. (2011) The enhancement of mature vessel formation and cardiac function in infarcted hearts using dual growth factor delivery with self-assembling peptides. Biomaterials 32(26): 6080-6088
4 Park, et al. (2007) Carbone nanotube monolayer patterns for directed growth of mesenchymal stem cells. Advanced Ma-terials 19(18): 2530–2534
5 Kim et al. (2007) Bone regeneration using hyaluroic acid based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 28(10): 1830-1837
Research Interest
Featured Publications
Cell Engineering Tissue Engineering Collective cell migration
Appendix 01 Faculty &
Laboratories 32 33
Lab of Brain Structure and Neural Network
PI: Im Joo RHYU, M.D., Ph.D. Department of Anatomy & Neuroscience
Contact Information E-mail: [email protected] Tel: +82 2 2286 1149 (Offi ce) / +82 2 2286 1381 (Lab)
Professor Rhyu is a Neuroanatomist with a background in medicine. He is interested in macroscopic and microscopic plastic response of the nervous system in response to various situations, especially motor activities. He demonstrated mac-roscopic plastic change of athletes’ brains with MRI. He investigates the ultrastructure of synapse with various electron microscopic techniques to understand the synaptic machinery and its roles in physiological and pathological conditions of the living.
To understand brain function based on morphological evidencesGOAL
1 Lee et al. (2014) Synapses need coordination to learn motor skills. Rev Neurosci. 25(2):223-30.
2 Lee et al. (2013) Motor skill training induces coordinated strengthening and weakening between neighboring synapses. J Neurosci. 33(23):9794-9.
3 Park et al. (2013) Regional cerebellar volume refl ects static balance in elite female short-track speed skaters. Int J Sports Med. 34(5):465-70.
4 Kim et al. (2013) Three-dimensional imaging of cerebellar mossy fi ber rosettes by ion-abrasion scanning electron micros-copy. Microsc Microanal. 5:172-7.
5 Kim et al. (2012) Growth patterns for acervuli in human pineal gland. Sci Rep. 2:984.
Research Interest
Featured Publications
Neuropathic pain Synaptic plasticity in learning & memory Synaptic vesicle release mechanism
Motor Coordination Acrobat training model Cerebellum development & related disease Human MRI volumetric study
Electron Microscopic Analysis Electron tomography Serial sectioning Electron Microscopy High voltage electron microscopy
Lab of GPCR and Signal Transduction
PI: Jae Young SEONG, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 1090 (Offi ce) / +82 2 2286 1092 (Lab) Homepage: http://gpcr.or.kr
JYS is interested in G-protein coupled receptors (GPCRs), particularly, neuropeptide GPCRs and orphan GPCRs. He is searching for ligands for orphan GPCRs, and investigating molecular interaction between ligands and receptors to devel-op novel agonists and antagonists. He is also studying evolution of neuropeptides and GPCRs using comparative genom-ics and bioinformatics. Bioinformatic tools allow identifi cation of novel uncharacterized neuropeptides.
Development of Drug Candidates for the Treatment of Neuro/Endocrine DiseasesGOAL
1 Kim et al. (2014) Coevolution of the spexin/galanin/kisspeptin family: spexin activates galanin receptor type II and III. Endocrinology 155:1864.
2 Hwang et al. (2013) Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplica-tions before and after two rounds of whole genome duplication. Mol Biol Evol 30:1119.
3 Moon et al. (2012) Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-in-duced receptor activation. J Biol Chem 287:3873
4 Lee et al. (2009) Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. Endocrinol-ogy 150:2837.
5 Kim et al. (2009) A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells. Cancer Res 69:923.
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 34 35
Lab of Infection and Immunity
PI: Ok Sarah SHIN, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2626 3280
Our lab focuses on understanding the mechanisms of the innate immune defense against bacterial/viral pathogens, such as Staphlycoccus aureus, infl uenza virus, varicella zoster virus (VZV) and hantavirus. Our ultimate goal is to utilize the knowledge we gain through these areas of research in the rational design of effective vaccines/adjuvants or immunother-apeutics for the prevention of transmission bacterial/viral pathogens.
Understanding of Host-Pathogen Interaction and ImmunosenescenceGOAL
1 Shin et al (2014) Hantaviruses induce antiviral and pro-infl ammatory innate immune responses in astrocytic cells and the brain. Viral Immunology. 2014 Aug;27(6):256-66.
2 Shin et al (2013) Hantaviruses induce cell type- and viral species-specifi c host microRNA expression signatures. Virology. 2013 Nov;446(1-2):217-24
3 Karlsson et al (2013) Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Science Translational Medicine. 2013 Jul 3;5(192):192ra86
4 Shin et al (2012) Distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses. Virology. 2012 Dec 5;434(1):43-9.
5 Shin et al (2011) LPLUNC1 modulates innate immune responses to Vibrio cholerae. Journal of Infectious Diseases. 2011 Nov;204(9):1349-57.
Research Interest
Featured Publications
Application of Systems Biology to study host immune responses
Investigation of detailed roles and mechanisms of Immunosenescence
Identifi cation of Anti-bacterial/viral molecules and vaccine/adjuvant candidates
Lab of Molecular Networks and Neurobiology
PI: Gi Hoon SON, Ph.D. Department of Biomedical Sciences/Legal Medicine
Contact Information E-mail: [email protected] Tel: +82 2 920 6147 (Offi ce) / +82 2 2286 1158 (Lab)
GHS is mainly interested in circadian rhythm and its implications in psychiatric and metabolic disorders. He is focusing on the issues how molecular circadian clockworks are integrated into the key biological pathways underlying circadian rhythm-related human diseases. In this regard, he is also trying to develop novel small molecules to modulate molecular biological rhythms crucial for human health and diseases.
Developing novel diagnostic and therapeutic targets/strategiesGOAL
1 Chung et al. (2014) Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regula-tion. Cell 157:858.
2 Son et al. (2011) The adrenal peripheral clock: impacts on circadian rhythm of glucocorticoid and circadian timing system. Front Neuroendocrinol 32:451.
3 Lee et al. (2011) Impairment of fear memory consolidation in maternally stressed male mice offspring: Evidence for nonge-nomic glucocorticoid action on the amygdala. J Neurosci 31:7131
4 Jo et al. (2010) Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci 13:1216.
5 Son et al. (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhyth-mic steroid production. Proc Natl Acad Sci USA 105:20970.
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 36 37
Lab of Cancer Biology
PI: Hoseok SONG, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2626 3301 (Offi ce) / +82 2 2626 2419 (Lab)
Professor Song is interested in deciphering the roles of microRNAs in governing differentiation and tumorigenesis. He has been using a genetically modifi ed human embryonic stem cell (hESC) line as a model system to exploit its potential to differentiate into various types of cells. Combined with CrossLinking ImmunoPrecipitation (CLIP) and high throughput sequencing, the hESC-based system allows for unbiased, genome-wide analysis of microRNA-mRNA network, which will provide novel insights in the roles of miRNAs in various aspects of biological processes.
Systematic analysis of miRNA-mRNA networkGOAL
1 Seong et al. (2014) Global identifi cation of target recognition and cleavage by the Microprocessor in human ES cell, Nu-cleic Acids Res., in press
2 Jung et al. (2014) Cell cycle-dependent regulation of Aurora kinase B mRNA by the Microprocessor complex, Biochem Biophys Res Commun. 446(1):241
3 Song et al. (2010) Modeling Disease in Human ESCs Using an Effi cient BAC-Based Homologous Recombination System, Cell Stem Cell 6(1):80
4 Song and Xu (2007) Gain of Function of p53 Cancer Mutants in Disrupting Critical DNA Damage Response Pathways, Cell Cycle 6(13):1570
5 Song et al. (2007) p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM, Nat Cell Biol. 9(5):573
Research Interest
Featured Publications
Modifi cation of hESC by gene targeting
A hESC-based model system to analyze miRNA-mRNA network
CrossLinking ImmunoPrecipiation (CLIP) method to identify protein-bound RNAs
A target mRNA identifi ed by CLIP
Lab of Molecular Virology
PI: Jin-Won SONG, M.D., Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2286 6408 (Offi ce) / +82 2920 6353 (Lab)
Professor Song is interested in global emerging viruses including hantaviruses and polar viruses. For discovery of a new virus, he is conducting serological and molecular studies. Also the novel virus is isolated and mapped by full genome se-quencing. Finally, he analyzes phylogenetic tree of the viruses and establishes their genetic information database. These studies can contribute to develop diagnosis, vaccine and therapy of emerging viral diseases and reduce them.
Virus HunterGOAL
1 Shin OS et al. (2014) Hantaviruses induce antiviral and pro-infl ammatory innate immune response in astrocytic cells and the brain. Viral Immunology.27(6):256-66.
2 Arai.S et al. (2012) Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea. Virology.424(2):99-105.
3 Park YM et al. (2012) Full genome analysis of a novel adenovirus from the South Polar skua (Catharacta maccormicki) in Antarc-tica. Virology.422(1):144-50.
4 Song JW et al. (2009) Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocid-ura lasiura). Journal of Virology.83(12):6184-91.
5 Song JW et al. (1994) Isolation of pathogenic hantavirus from white-footed mouse (Peromyscus leucopus). Lancet.344(8937):1637
1998 Hantaan Prize, The Hantaan Life Science Foundation, Seoul, Korea2011 56th the National Academy of Sciences Award, Korea National Academy of Sciences, Seoul, Korea
Research Interest
Featured Publications
Honors and Awards
Appendix 01 Faculty &
Laboratories 38 39
Lab of Biomedical Proteomics
PI: Donggeun SUL, Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 920 6614
Professor Sul is interest in development of biomarkers related in biomedicine and toxicology using proteomic analysis. Human plasma proteins and cell secreted proteins are major target for proteomic study. Protein based Lab-on-a-chip has been developed to evaluate the exposure rate of environmental toxicants. Recently, IdMOC system has been focused on development of proteomic biomarkers of various drugs.
Development of Proteomic BiomarkersGOAL
1 Choi et al. (2014) Plasma proteomic analysis of patients infected with H1N1 infl uenza virus. Proteomics. In Press.
2 Park et al. (2012) Toxicological biomarkers of 2,3,4,7,8-pentachlorodibenzofuran in proteins secreted by HepG2 cells. Biochim Biophys Acta. 1824(4):656-66.
3 Choi et al. (2010) Identifi cation of toxicological biomarkers of di(2-ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis. Proteomics. 10(9):1831-46.
4 Jung et al. (2009) Analysis of low molecular weight plasma proteins using ultrafi ltration and large gel two-dimensional electrophoresis. Proteomics. 9(7):1827-40.
5 Im et al. (2006) Evaluation of toxicological monitoring markers using proteomic analysis in rats exposed to formalde-hyde. J Proteome Res. 2006 Jun;5(6):1354-66.
Research Interest
Featured Publications
Development of Lab-on-a-chip of PAH Toxicological biomarkers of drugs using IdMOC system
Lab of Neural Development and Stem Cell Research
PI: Woong SUN Departments of Anatomy and Neuroscience
Contact Information E-mail: [email protected] Tel: +82 2 2286 6404 (Offi ce)
WS has been exploring the molecular and cellular mechanisms of the programmed cell death of neurons in the embry-onic and adult nervous systems under the physiological or pathological settings, with special emphasis on the mitochon-dria-driven death signals. He is also interested in the multidisciplinary fusion researches for in vitro production of neural chips and 3D neuronal tissues from stem cells.
Knowledge-based R&D for brain diseasesGOAL
1 Kim et al. (2014) Surface-printed microdot array chips for the quantifi cation of axonal collateral branching of a single neuron in vitro. Lab Chip, Feb 21; 14(4):799-805.
2 Kim et al. (2013) (ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neu-ronal degeneration in a mouse model of Parkinson’s disease. Cell Death & Dis, 4:e919.
3 Moon et al. (2013) Function of Ezrin-Radixin-Moesin Proteins in Migration of Subventricular Zone-Derived Neuroblasts Following Traumatic Brain Injury. Stem Cells. 31:1696-705.
4 Choi et al. (2013) Drp1-mediated mitochondrial dynamics and survival of developing chick motoneurons during the period of neuronal programmed cell death. FASEB J 27:51-62.
5 Wenlin et al. (2011) Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. PNAS, 108(20):8299-304.
Research Interest
Featured Publications
Neuronal Cell Death and neurodegeneration Mechanism of developmental PCD MN death in ALS and PD
Stem Cell Biology of adult neurogenesis Neural stem cell for brain repair Engineering endogenous NSCs
Fusion Research for Neuron chip/3D culture Micro-contact surface pattering Neuronal spheroid culture
Appendix 01 Faculty &
Laboratories 40 41
Clinical Research Units
Professor Laboratory
CHO, Jae-Gu Department of Otorhinolaryngology-Head and Neck Surgery
CHOE, Jae Gol Department of Nuclear Medicine
HAM, Byung-Joo Interdisciplinary Affective Neuroscience Lab
HONG, Soon Cheol Lab of Placenta Stem Cells
KIM, Aeree Department of Pathology
KIM, Byung Soo Department of Medical Oncology and Hematology
KIM, Dong-Sik Lab of HBP Surgery & Liver Transplantation
KIM, Hyun Koo Lab of Image-guided Cancer Surgery
KIM, Min Ja Lab of Infection and Immunity
KIM, Woo Joo Department of Infectious Diseases
KIM, Yeul Hong Cancer Research Institute
LEE, Chang Kyu Department of Lab Medicine
LEE, Heon-Jeong Lab of the Circadian Rhythm & Mood Disorders
LEE, Heung Man The Upper Airway Research Institute (TUARI)
LEE, Suk Lab of Medical Physics
LIM, Chae Seung Lab of Biomedical Engineering
LIM, Do-Sun Lab of Cardiac Regeneration
OH, Sang Cheul Lab of Gastrointestinal Cancer Biology
PARK, Jong Woong Hand Surgery & Reconstructive Microsurgery
PARK, Kyong Hwa Department of Medical Oncology and Hematology
RHA, Seung-Woon Cardiovascular Intervention and Research Institute
SEO, Jae Hong Lab of Breast Cancer Targeting Drug
SHIN, Chol Korean Genome and Epidemiology Study (KoGES)
SHIN, Sang-Wan Lab of Dental Research
SON, Sang Wook Lab of Cell Signaling and Nanomedicine
SONG, Hae Ryong Lab of Bone Defect/Disease Fusion-Therapy Center
SUH, Seung-Wo Department of Orthopedic Surgery
YOO, Hye Jin Lab of Diabetes & Atherosclerosis
YOON, Soo-Young Lab of Diagnostic Technology Development
Appendix 01 Faculty &
Laboratories 42 43
Lab of Interdisciplinary Affective Neuroscience
PI: Byung-Joo HAM, M.D., Ph.D. Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 920 6843
Professor Ham’s research interest is combining interdisciplinary approaches for better understanding of both normal and abnormal affective processes. Various methods complementary to each other including structural/functional neuroimag-ing and epigenetics are adopted to more comprehensive understanding of human affection.
Understanding normal / abnormal mechanisms of human affectionGOAL
1 Han et al. (2014) Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their fi rst episode of major depression. Journal of Affective Disorders, 155:42-48.
2 Lee & Ham (2008) Serotonergic genes and amydala activity in response to negative affective facial stimuli in Korean women. Genes, Brain and Behavior, 7(8):899-905.
3 Lee et al. (2008) Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32(3):778-785
4 Seok et al. (2013) Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder. Neuroscience letters. 545(17):35-39.
5 Lee et al. (2011). DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli. Behavioural Brain Research. 223(1):36-41.
Research Interest
Featured Publications
Multimodal Imaging Voxel Volumetry Surface Thickness Analysis Diffuser Tensor Imaging Resting-state fMRI
Genetics & Epigenetics Gene variation & methylation analysis related to individual differences
Major Depressive Disorder & Bipolar Disorders Brain abnormalities related to affective disorders
Lab of Placenta Stem Cells
PI: Soon-Cheol HONG M.D. Ph.D Department of Obstetrics and Gynecology
Contact Information E-mail: [email protected] Tel: +82 2 920 6602
Prof. Hong is interested in the effect of folic acid for pregnancy women and cell therapy which is derived from human placenta. Especially, he is focused on new drug candidates, and has been continuing to study this experiment. Also, He has been studying developmental toxicity including Folic acid’s functions and cell availability for cell therapy.
To use the placenta stem cells as cell therapy and as the new test for reproductive toxicology
GOAL
1 Kim MW, Ahn KH, Ryu KJ, Hong SC et al. (2014)Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes, PLOS One 2014; 9(5):
2 Cho GJ et al.(2013)Trends in the rates of peripartum hysterectomy and uterine artery embolization ,PLoS One. 2013;8(4):e60512.
3 Postpartum uterine involution: sonographic changes in the endometrium between 2 and 6 weeks postpartum related to mode and gestational age at delivery. Ultrasound Obstet Gynecol 2012 Jun;39(6):727-8
4 Kim MW (2012) Homocysteine, folate and pregnancy outcomes.J Obstet Gynaecol. 2012 Aug;32(6):520-4
5 Hong SC (2010) Stemness Evaluation of Mesenchymal Stem Cells from Placentas According to Developmental Stage: Comparison to Those from Adult Bone Marrow. Journal of Korean Medical Science. 2010, JulyOct;25(10):1418-26
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 44 45
Lab of HBP Surgery & Liver Transplantation
PI: Dong-Sik KIM, M.D., Ph.D. Division of HBP Surgery & Liver Transplantation, Department of Surgery Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 920 6620
DSK is interested in translational research in the fi eld of hepatobiliary disease and liver transplantation. Recent research topics include primary hepatocyte culture using 3-D fl atform, effects of various drugs including immunosuppressives on hepatic steatosis and fi brosis, elucidation of mechanism and therapeutics development for liver regeneration and small-for-size syndrome, ischemia-reperfusion injury in animal models or human transplantation.
1 S. A. Lee, D. Y. No, E, Kang, J. Ju, D. S. Kim and S. H. Lee Spheroid-based three-dimensional liver-on-chip to investigate hepatocyte-hepatic stellate cell interaction and fl ow effects. Lab on a chip 2013; 13(18):3529-3537
2 J.H. Kwo, N. Lee, J. Y. Park, Y. S. Yu, J. P, Kim, J. H. Shin, D. S. Kim, J. W. Joh, D. S. Kim, K. Y. Choi, K. J. Kang, G. Kim, Y. H. Moon and H. J. Wang Actionable gene expression-based patient stratifi cation for molecular targeted therapy in hepatocellular carcinoma. PLoS One 2013;8(6):e64260
3 S. M. Kwon, D. S. Kim, N. H. Won, S. J. Park, Y. J. Chwae, H. C. Kang, S. H. Lee, S. Thorgeirsson, H. G. Woo Genomic copy number alter-ations with transcriptional deregulation at 6p identify an aggressive HCC phenotype. Carcinogenesis 2013;34(7):1543-50
4 D. Y. No, S. A. Lee, Y. Y. Choi, D. Park, J. Y. Jang, D. S. Kim, amd S. H. Lee Functional 3D human primary hepatocyte spheroids made by co-culturing hepatocyte from partial hepatectomy specimen and human adipose-derived stem cells. PLoS One 2012;7(12):e50723
5 Y. D. Yu, D. S. Kim, G. Y. Byun and S. O. Seo Can propranolol be a viable option for the treatment of small-foe-size syndrome? Liver Transpl 2012;18(6):747-8
Research Interest
Featured Publications
3D Primary hepatocyte culture Found a relationship between portal fl ow and hepatocyte Designing of 3D culture fl ow chip Improvement of hepatocyte function
Nonalcoholic-Steatohepatitis Development of NASH animal model In vivo, In vitro effi cacy of Immunosuppressives
Small-for-size syndrome Development of liver failure model Choosing the drug candidate In vivo effi cacy of drug candidates
Lab of Image-guided Cancer Surgery
PI: Hyun Koo KIM, MD, Ph.D Department of Thoracic and Cardiovascular Surgery
Contact Information E-mail: [email protected] Tel: +82 2 2626 3106
Prof. Kim’s research interests cover three areas : 1) Intralymphatics delivery system of nanoparticle based chemothera-peutics for cancer treatment, 2) Image-guided cancer surgery using NIR fl uorescent imaging system and 3) Development of smart surgical goggle for image guided cancer surgery. For various research, his lab have collaborated with Dept. of Biomedical Engineering of Korea University, Bio and Brain Engineering of KAIST and Nuclear Medicine of Seoul National University.
1 (2014) Thoracoscopic color and fl uorescence imaging system for sentinel lymph node mapping in porcine lung using indocyanine green-neomannosyl human serum albumin:intraoperative image-guided sentinel nodes navigation. Ann. Surg. Oncol. 6;21(4):1182-8.
2 (2014) Gallium-68 Neomannosylated Human Serum Albumin-Based PET/CT Lymphoscintigraphy for Sentinel Lymph Node Mapping in Non-Small Cell Lung Cancer. Ann Surg Oncol. In press
3 (2014) Needlescopic Resection of Small and Superfi cial Pulmonary Nodule After Computed Tomographic Fluoroscopy-Guided Dual Localization with Radiotracer and Hookwire. Ann Surg Oncol. In press
4 (2013) Intraoperative combined color and fl uorescent images-based sentinel node mapping in the porcine lung: Comparison of indo-cyanine green with or without albumin premixing. J Thorac Cardiovasc Surg 146(6):1509-15
5 (2012) Comparison between Preoperative Versus Intraoperative Injection of Technetium-99 m Neomannosyl Human Serum Albumin for Sentinel Lymph Node Identifi cation in Early Stage Lung Cancer. Ann Surg Oncol. 19:1343-1349
6 (2011) Sentinel node identifi cation using technetium-99m neomannosyl human serum albumin in esophageal cancer. Ann Thorac Surg. 91(5):1517-22.
Research Interest
Featured Publications
Intralymphatics chemotherapy NIR Fluorescent imaging system Smart Surgical Goggle System
Minimal Incision and Resection of Tumor using Image-guidance Surgery and Local Chemotherapy
GOAL
Appendix 01 Faculty &
Laboratories 46 47
Lab of Infection and Immunity
PI: Min Ja KIM, M.D., Ph.D. Dept. of Internal Medicine, Div. of infectious Diseases
Contact Information E-mail: [email protected] Tel: +82 2 920 5096 (Offi ce) / +82 2 920 6256 (Lab)
The major topics include elucidation of early host innate immune responses during severe bacterial infection and the related diagnostic, prognostic and therapeutic molecular biomarkers for control of severe bacterial infection. Using the differently susceptible mouse model of Legionnaires’ disease, role and dynamics of immune cells, together with various infl ammatory chemokines and cytokines profi les are being investigated. Especially, genetic difference in activation of infl ammasomes is under exploration as a cytoplasmic sensor for intracellular pathogen. Other topics are development of diagnostic bio-markers based on CGH data for Legionnairs’ disease and characterization of changing patterns of pneumococcal serotypes following pneumococcal vaccination in older people.
1 Yoon YK, Kim MJ et al. (2014) Multicenter prospective observational study of the comparative effi cacy and safety of vancomycin versus teicoplanin in patients with health care-associated methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 58(1):317-324.
2 Yoon YK, Kim MJ et al. (2012) Clinical prediction rule for identifying patients with vancomycin-resistant enterococci (VRE) at the time of admission to the intensive care unit in a low VRE prevalence setting. J Antimicrob Chemother. 2012 Dec;67(12):2963-9.
3 Park DW, Kim MJ et al. (2012) Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: a propensity-matched analysis*. Crit Care Med. 40(12):3140-3145.
4 Yoon YK, Kim MJ et al. (2011) Risk factors for prolonged carriage of vancomycin-resistant Enterococcus faecium among patients in intensive care units: a case-control study. J Antimicrob Chemother. 66(8):1831-1838.
5 Shim HK, Kim MJ et al. (2009) Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages. Exp Mol Med. 41(10):687-694.
NOD-like receptors and Innate immune responses Analysis of innate immune cell activation in mouse model of Legionnaires’ disease pneumonia
Insights into activation of infl ammasomes
Discovery of Diagnostic biomarkers for detection of Legionnaires’ disease CGH-based screening for specifi c candidate genes Development of multiplex real-time PCR assay for rapid detection and differentiation of Legionella species
Research Interest
Serotyping and Diagnostics of Streptococcus pneumoniae Diagnostic approaches to differentiate between invasive and noninvasive pneumococcal diseases and pneumonia and colonization
Multiplex pneumococcal serotyping assay using luminex
Featured Publications
Cancer Research Institute
PI: Yeul Hong KIM, MD, Ph.D, Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +829205569(Offi ce)/+82222861258(Lab)
Professor Kim (Director, Korea University Cancer Research Institute) is interested in translational research in lung and GI cancer. Since 2001, many study results was reported through cancer genome research. Recently, using next-generation sequencing (NGS) in lung adenocarcinoma with wild-type EGFR was discovered genomic alterations. Currently, NGS-based cancer panel using tissue and cell free DNA are developing, and carry out gastric cancer stem cell research for the elimina-tion of gastric cancer cells.
1 Jo et al. (2014) EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR. Oncotarget. 5:1265-78.
2 Kim et al. (2013) Predictive effi cacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma. PLoS One. 8:e81975.
3 Whang et al. (2013) Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. PLoS One. 8(1):e53012.
4 Ohtsu et al. (2013) Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study. J Clin Oncol. 31(31):3935-43.
5 Lan et al. (2012) Genome-wide association analysis identifi es new lung cancer susceptibility loci in never-smoking wom-en in Asia. Nat Genet. 44(12):1330-5.
Research Interest
Featured Publications
Appendix 01 Faculty &
Laboratories 48 49
Lab of the Circadian Rhythm & Mood Disorders
PI: Heon-Jeong LEE, M.D., Ph.D. Department of Psychiatry Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 920 6721 (offi ce) Homepage: http://kuhjnv.wix.com/circadianrhythmmood
Circadian rhythms are cyclic and persistent patterns of behavior, physiological changes, and mental characteristics exhibited by most living organisms on the Earth, from bacteria to humans. They occur with a 24-h period and are thus roughly refl ective of the time it takes for the Earth to complete a rotation. Prof. Lee has been interested in correlations of circadian rhythm with mood disorders. He recognized that patients suffering from mood disorders (e.g. bipolar disorder) are in disrupted circadian rhythm. Furthermore, his research team has found out that particular stress such as irregular sleep cycle and light pollution destroys healthy circadian rhythms in a group of people. The molecular mechanisms connecting circadian rhythm with stress and mood disorder are lively being investigated.
Development of new strategies for treating and preventing mood disorders by circadian rhythm consolidation.
GOAL
1 Jung et al. (2014) Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizo-phrenia. Chronobiol Int. epub.
2 Lee et al. (2013) Circadian rhythm hypotheses of mixed features, antidepressant treatment resistance, and manic switch-ing in bipolar disorder. Psychiatry Investig. 10:225-32.
3 Lee et al.(2013). A genome-wide association study of seasonal pattern mania identifi es NF1A as a possible susceptibility gene for bipolar disorder. J Affect Disord. 145(2): 200-7.
4 Lee et al. (2011). Delayed sleep phase syndrome is related to seasonal affective disorder. J Affect Disord. 133:573-9.
5 Lee et al. (2011). PER2 Variation is Associated with Diurnal Preference in a Korean Young Population. Behav Genet. 41:273-7.
Circadian Rhythm and Bipolar DisordersCircadian rhythm instability, imposed on the dysregulation of HPA axis and monoamine system, may in turn increase indi-vidual susceptibility for Bipolar disorders.
Polysomnography and Actigraphy Sleep study with full polysomnography and actigraphy are used for the circadian rhythm disturbances.
Circadian Rhythm Management for Mood disorders Invention of gene chip for circadian rhythm Invention of circadian manager using wearable devices
Research Interest
Featured Publications
The Upper Airway Research Institute (TUARI)
PI: Heung-Man LEE, M.D., Ph.D. Department of Otorhinolaryngology-Head and Neck surgery, Department of Biomedical Sciences
Contact Information E-mail: [email protected] Tel: +82 2 2626 3185 (Offi ce) / +82 2 2626 1986 (Lab) Homepage: http://tuari.korea.ac.kr/
Professor Lee is interested in therapeutic application and molecular mechanism of airway infl ammatory disease: epigen-etic regulation, natural product test, epithelial to mesenchymal transition, role of infl ammatory cytokine and chemokine, and preclinical study. He is d