Pioneering Technologies For Lifestyle Based Medicine

Innovations in Hormone Testing

Mark NewmanFounder and CEO of Precision Analytical, Inc

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presents

Pioneering Technologies For Lifestyle Based Medicine

Mark NewmanFounder and CEO of Precision Analytical, Inc

Scientist Mark Newman is one of the foremost experts and an international speaker in the area of hormone testing. He has designed several hundred tests in multiple labs before starting his own lab, Precision Analytical, Inc.

Mark has educated thousands of physicians on hormone testing and best practices. He has particular expertise in the testing of adrenal and reproductive hormones, especially as it relates to the appropriate monitoring of hormone replacement therapy.

Mark has directed lab testing at multiple industry-leading hormone testing laboratories including Meridian valley Labs, ZRT Laboratory and Precision Analytical, Inc.

Saliva Serum 24-Hr Urine

TESTING MATRIX

See educational videos at dutchTest.com

Dried Urine Test for Comprehensive Hormones

What is ?

• 4 Easy, Dried Urine Collections

What is ?

Dried Collections are Easier

Unpublished data, Precision Analytical

• 4 Easy, Dried Urine Collections

• Individual Samples Tested for “Free” Cortisol• Correlates with salivary cortisol pattern

What is ?

Jerjes, (2005, 2006)

Urinary Free Cortisol

Salivary Free Cortisol

Do Urine & Saliva Free Cortisol Agree?

Urine (dried) Free Cortisol

• 4 Easy, Dried Urine Collections

• Individual Samples Tested for “Free” Cortisol• Correlates with salivary cortisol pattern

• Combined sample (weighted average) tested

for all metabolites• Estrogen, Androgen, Progesterone, Cortisol

• Strong 24-hr Correlation

What is ?

24-Hour Correlation

Saliva Serum 24-Hr Urine

What is hormone testing good for?

• Disease States

• Functional Endocrinology

• HRT Monitoring

What is hormone testing good for?

• “Disease States”• Opioid Hormonal Suppression

• Addison’s Disease

• Cushing’s Disease

• Congenital Adrenal Hyperplasia

Young Male Patient On An Opioid

What is hormone testing good for?

• “Disease States”• Opioid Hormonal Suppression

• Addison’s Disease

• Cushing’s Disease

• Congenital Adrenal Hyperplasia

CAH (Congenital Adrenal Hyperplasia)

What is hormone testing good for?

• Disease States

• Functional Endocrinology

DUTCH & Functional Endocrinology,

An ideal match!

“High Cortisol Associated withAnorexia”

Cortisol & DHEA Production are Low!

Hypersecretion or Impaired Metabolism?

“High free Cortisol Associated with Anorexia due to low

production and highly impaired metabolism”

Thyroid directly impacts cortisol clearance

Thyroid directly impacts cortisol clearance

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Hashimoto’s Patient

Before-and-after Reducing Thyroid

If patients have thyroid conditions, DUTCH is a better option for adrenal testing

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DUTCH Report

Hyperthyroid?

DUTCH Report

Patient is 5’2”, 250lbs

Obesity:What Generally Happens?

N>5,000Precision Analytical, Inc (unpublished)

N>5,000Precision Analytical, Inc (unpublished)

If patients are obese, DUTCH is a better option for adrenal testing

Fat Cells Trap & Metabolize Cortisol

THOUSANDS OF PATIENTS LIKE THIS HAVE BEEN TREATED FOR

“ADRENAL FATIGUE”

CAH

Obese

A DUTCH Case Study:• Female• Postmenopausal• Obese• Many symptoms (high androgens, fatigue, etc,)

Where is all that estrogen coming from?

Where is all that estrogen coming from?

Where is all that estrogen coming from?Where is all that estrogen going?

Where is all that estrogen going?

Option A

Option B

Postmenopausal, obese patientInflammation

• Increases estrogen• Blocks sulfation• Pushes cortisone cortisol

Functional Endocrinology - Androgens

Questions answered by most tests

• DHEA low/normal/high?

• Testosterone low/normal/high?

Questions answered only with metabolites

• Androgenic metabolism (5a)?

Functional Endocrinology - Estrogens

Questions answered by most tests

• Estradiol low/normal/high?

Questions answered only with metabolites

• Phase I metabolism (2-OH, 4-OH, 16-OH)?

• Phase II metabolism (methylation)?

BEFORE & AFTER D.I.M.

Expanding Estrogen Testing with Metabolites

The Genetic Connection

The Power of Testing Metabolites

What is hormone testing good for?

• Disease States

• Functional Endocrinology

• HRT Monitoring

HRT Monitoring

HRT Monitoring

HRT Monitoring

HRT Monitoring

HRT Monitoring

TESTING MATRIX

DUTCH – A great option

• Disease States

• Functional Endocrinology

• HRT Monitoring

Saliva Serum 24-Hr Urine

Cycle Mapping Option (premenopausal)

• Complete ($250)• Adrenal ($150)

• Sex Hormone Metabolites ($150)

• Cycle Mapping ($325, $425)

Sign up at dutchTest.com

If you would like a copy of this presentation, please contact: 1-855-667-1967

Thank You!Mark Newman

Founder and CEO of Precision Analytical, Inc