Upload
others
View
9
Download
0
Embed Size (px)
Citation preview
Hôpitaux
Universitaires
Genève
Innovations in multimodality
imaging devices
Habib Zaidi1,2,3
1Geneva University Hospital, Geneva, Switzerland 2University of Groningen, Groningen, Nethelands 3University of Southern Denmark, Odense, Denmark
Email: [email protected]
Web: http://pinlab.hcuge.ch
3rd Global Forum on Medical Devices, 10-12 May 2017
Convergence of multiple image-capture techniques, basic cell/molecular
biology, chemistry, medicine, pharmacology, medical physics,
biomathematics, and bioinformatics into a new imaging paradigm
Anatomic Physiologic Metabolic Molecular
PET/SPECT
x-ray CT
MRI
ultrasound
optical imaging
Molecular Imaging: Interdisciplinary!
From 2-D to 5-D multimodality imaging
5-D PET/CT
2-D projections
3-D CT
4-D CT
4-D PET
3-D PET
Zaidi H. Navigating beyond the 6th dimension: A challenge in the era of multi-parametric molecular imaging (2009) EJNMMI 36: 1025-28
Navigating beyond the 5th dimension …
Beyond pretty images …
Early references to emission/transmission imaging
Mayneord WV (1952) The radiology of the human body with radioactive isotopes. Br J Radiol 25: 517-525 Kuhl DE, J Hale, WL Eaton (1966) Transmission scanning: A useful adjunct to conventional emission scanning for accurately keying isotope deposition to radiographic anatomy. Radiology 87: 278-284 Anger HO, J McRae (1968) Transmission scintiphotography. J Nucl Med 9: 267-269 Sorenson JA, RC Briggs, JR Cameron (1969) 99mTc Point Source for Transmission Scanning. J Nucl Med 10: 252-253 Tothill P, JM Galt (1971) Quantitative profile scanning for the measurement of organ radioactivity. Phys Med Biol 16: 625-634 Budinger TF, GT Gullberg (1974) Three-dimensional reconstruction in nuclear medicine emission imaging. IEEE Trans Nucl Sci 21: 2-20
Description of a Simultaneous Emission-Transmission CT System Hasegawa BH et al SPIE Vol 1231 Medical Imaging IV Image Formation (1990)
UCSF Emission/Transmission CT (1993)
HPGe detector
LN2 cryostat
X-ray tube
Correlated Image
CT
X-Ray CT Radionuclide Emission
SPECT
Computer
Courtesy Dr Bruce Hasegawa
1951-2008
Anatomy
(CT)
Fusion
(SPECT/CT)
+
=
Function
(SPECT)
Scout Spiral CT PET PET/CT
Principles of PET/CT
Trimodality m PET/m SPECT/m CT
FLEX Triumph™ Tri-modality system
LabPET ™ - Gamma Medica
LabPETTM ~1 mm
Benefits of combined PET/MRI
Direct and accurate registration of molecular PET signal with high
resolution MR anatomy
Better soft tissue contrast than CT
No radiation dose
Anatomically-guided reconstruction of PET data
Improved quantification of PET data
Time correlation of PET and MRI or MRS signal
Interventional, therapeutic studies
Dual-labeled agents (64Cu, Gd)
Dual-agent molecular imaging/cell tracking
Reduced positron range – improvements in the in-plane spatial
resolution (high b+ energy)
Potential designs of combined PET-MRI
Full integration
Sequential (Tandem/docked)
PET insert within MRI
Zaidi and Del Guerra (2011) Med Phys
Commercially available PET-MRI scanners
GE SIGNA PET/MR
Patient Transfer Table Top (PTTP) PET/CT MRI
Clinical whole-body PET/MRI
SIGNA PET/MR
GEMINI TF PET/MR Biograph mMR
Summary
PET/MR is producing challenges in terms of software/hardware
development but also plenty of opportunities.
MR sequences is the key for providing answers to a number of
issues.
Existing approaches previously developed in PET/CT multimodality
imaging may be explored within the PET/MR field.
New software developments are necessary to efficiently explore the
multitude of information that may be available from PET/MR.
Presently available multimodality imaging systems:
PET/CT, SPECT/CT, PET/SPECT, PET/SPECT/CT, PET/MRI,
PET/Optical
From PET/CT … to PET-MR
Will PET/MRI replace PET/CT?
Zaidi and Mawlawi Med Phys 34: 1525-1528 (2007)
Clinical applications of PET-MRI
Still the bottleneck of PET-MRI …