.Periodic iron mineralization …… in human serum transferrin fibrils has been observed by microscopy, as described byP. J. Sadler, S. Verma, and co-workers in the Communication on page 2217 ff. Thepicture shows transferrin as a ribbon structure, typical micrographs of the fibers, and thediffraction pattern of a fiber nanocrystallite (which resembles the iron oxide/hydroxidemineral shown in a space-filling representation). These findings suggest a previouslyunknown biological role for transferrin.

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Surajit Ghosh, Arindam Mukherjee, Peter J. Sadler,* andSandeep Verma*

Periodic iron mineralization in human serum transferrin fibrils has been observed bymicroscopy, as described by P. J. Sadler, S. Verma, and co-workers in theCommunication on page 2217 ff. The picture shows transferrin as a ribbon structure,typical micrographs of the fibers, and the diffraction pattern of a fiber nanocrystallite(which resembles the iron oxide/hydroxide mineral shown in a space-fillingrepresentation). These findings suggest a previously unknown biological role fortransferrin.