Upload
phamanh
View
214
Download
0
Embed Size (px)
Citation preview
Institute of Organic Chemistry
with Centre of Phytochemistry
Bulgarian Academy
of Sciences
Institute of Organic Chemistry with Centre
of Phytochemistry
• The Institute was established in 1960.
• The Centre of Phytochemistry was
founded in 1977, within a joint project
of the Bulgarian Government, UNDP
and UNESCO for scientific and applied
research and training of specialists.
Natural Products
• Characterization of the chemical diversity and health promoting potential of Bulgarian flora
• Isolation of new biologically active natural compounds (alkaloids, terpenoids, flavonoids and other phenolics)
• Development of methods for standardization and quality control of Bulgarian medicinal plants and propolis
Natural Bioactive Products
• Studies of pectic substances and other bioactive polysaccharides
• Investigation of the antioxidant properties of fruits, vegetables, herbs and mushrooms.
• Development of new technologies for functional foods (Through contract with the small enterprise “VITANEA”)
Organic synthesis and Stereochemistry
Equipment for organic and organometallic
transformations; synthesis of natural
compound analogues and pharmaceutical
ingredients
Organic synthesis and Stereochemistry
• Rational design of chiral ligands based on readily available
natural chiral sources
• Development of metal-mediated and organocatalytic systems
for enantioselective transformations and synthesis of
terapeuticaly relevant structures
• Investigation of the stereochemical course of selective
transformations and configuration determinations
• Contract research collaborations with pharmaceutical
companies – design and synthesis of “compound-libraries” for
development of drug candidates
Organic Analysis Labs
• Bulgarian NMR Centre
• Laboratory “Mass spectrometry &
Instrumental chromatography”
• Electronic and vibrational spectroscopy
• Elemental analysis
NMR Spectroscopy
• Structural analysis and stereochemistry - small and medium
size molecules – conformation and configuration, mixture
analysis
• Molecular mobility - classic dynamic NMR, nuclear relaxation
methods, DOSY spectroscopy
• Supramolecular aggregates and complexes - molecular
recognition with cyclodextrines; structure and composition of
surfactant solutions; colloid and water soluble polymers as
drug delivery systems;
• Computer programs and spectral databases
Mass spectrometry & Instrumental
chromatography
High resolution magneto-sector mass spectrometer DFS HRGC/HRMS/DS
(CI, EI, ESI. APCI)
- Analysis of new compounds, mixtures, composits
of natural and synthetic origin
- New methods for determination of composition,
quality and authenticity of foods
- Expert evaluation of identity, purity and quality
parameters of chemical and pharmaceutical
products
Organic Analysis
Most important ongoing projects: • Chiral Cations and Ligands with Tunable Properties for
Asymmetric Synthesis and Catalysis (project funded by Swiss National Science Foundation, collaboration IOCCP-BAS and Department of Organic Chemistry, University Geneva)
• Bees in Europe and the decline of bee colonies (search for natural products active against bee pathogens) BEEDOC (project funded by FP-7)
• Innovative Chiral Catalysts Based on Auxiliaries from the “Chiral Pool” (project funded by Bulgarian National Science Fund)
• Infraspecific diversity, biologically active substances, selection of perspective habitats, cultivation and sustainable use of Tribulus terrestris L. for the pharmaceutical industry (project funded by Bulgarian National Science Fund)
• Design, synthesis and photophysical investigations of self organized nanoassemblies of noble metal nanoparticles and organic luminophores (project funded by Swiss National Science Foundation, collaboration IOCCP-BAS and Department Physical Chemistry, University Geneva)
Most important ongoing projects: • Fluorophore modified noble metal nanoparticles – new
materials for bio- and chemical sensors (project funded by Bulgarian National Science Fund)
• Study of the pharmacological potential of Bulgarian medicinal plants to treat experimental osteoporosis: taxonomic, phytochemical and in vivo/in vitro biomedical research (project funded by Bulgarian National Science Fund)
• Bulgarian NMR Centre – Development of Advanced and Effective Research Infrastructure for NMR Analysis of Bio- and Nanomaterials (project funded by Bulgarian National Science Fund)
• Enhancing Access and Services To East European users towards an efficient and coordinated pan-European pool of NMR capacities to enable global collaborative research and boost technological advancements – EAST-NMR (FP7 INFRA-2008-1.1.1)
• „European Phosphorus Sciences Network (PhoSciNet)” COST CM0802
Existing national co-operations
Joint
Genomic
Centre
Molecular
biology
Sofia
Medical
University
Sofia
University
Polymers
Micro-
biology
Biodiversity
IOCCP
Existing international co-operations
University
of Athens
University
of Malta
Vrije
Universiteit
Brussel
Romanian
Acad. Sci.
University
of Skopje
IOCCP
University
of Geneva
Slovak
Acad. Sci.