296 instructions for earning self-assessment category I credit J. ALLERGY CLIN. IMMUNOL. SEPTEMBER 1991 INSTRUCTIONS FOR EARNING SELF-ASSESSMENT CATEGORY I CREDIT Pleasenote. The answersheets for receiving CME credit required, participants can call the American Academy of areno longer included with the self-assessment articles. The Allergy and Immunology office (414/272-6071) for answer self-assessment questions and answers, however,are printed sheets that should be completedand returned for receipt of for those wishing to assess themselves. If CME credit is Category I credit. CME examination Identification No. 099152 Vercelli D, Geha RS. Regulation of IgE synthesis in humans: A tale of two signals. J ALLERGY CLIN IMMUNOL 1991;88:285-95. Questions l-20 Choose correct answer(s) for each of the following questions: 1. The CD40 antigen is expressed on: a. Monocytes b. T cells c. B cells d. Mast cells e. Endothelial cells 2. Induction of IgE synthesis in B cells stimulated with IL-4 and anti-CD40 MAb or EBV results from: a. Isotype switching of sIgE- B cell precursors b. Expansion of an sIgE+ B cell population c. Expansion of sIgG+ B cell population 3, EBV infects and transforms: a. Monocytes b. B cells c. T cells d. Platelets 4. E Germ-line transcripts derive from: a. C, exons b. S, region c. I, exon d. S, region and the C, exons e. I, exon and the C. exons 5. The agentsthat regulate isotype switching mod- ulate: a. Translation of immunoglobulin heavy chain genes b. Accessibility of specific S regions to the re- combinase c. Glycosylation of IgE proteins d. Turnover of immunoglobulin 6. IL-4 by itself is able to induce: a. Mature E mRNA b. IgE isotype switching c. E Germ-line transcripts d. RNA transsplicing 7. Ongoing IgE synthesis in the HIE syndrome is: a. T cell dependent b. IL-4 dependent c . ILd-dependent d. T cell and lymphokine independent 8. Allergen-specific CD4 + T cell clones from atopic patients produce: a. High levels of IL-4 b. Low levels if IL-4 c. High levels of IL-2 d. Low levels of IL-2 9. CD40 is homologousto the receptor for: a. IL-2 b. TGF-P c. TNF-(w d. IL-6 e. IL-1 10. IgE synthesisby IL4-stimulated B cells requires endogenous: a. IL-2 b. IL-5 c. IL-3 d. IL-6 11. IgE synthesisrequires: a. IL-4 b. IL-5 c. B cell-activating signal d. IL-4 and IL-5 e. IL-4 and a B cell-activating signal 12. IFN-y: a. Inhibits IgE synthesis b. Enhances IgE synthesis c. Is required for IgE synthesis d. Has no effect on IgE synthesis 13. IL-6 acts on: a. B cell commitment b. Early stage in B cell differentiation c. IgE isotype switching

Instructions for earning self-assessment category I credit

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296 instructions for earning self-assessment category I credit J. ALLERGY CLIN. IMMUNOL. SEPTEMBER 1991

INSTRUCTIONS FOR EARNING SELF-ASSESSMENT CATEGORY I CREDIT

Please note. The answer sheets for receiving CME credit required, participants can call the American Academy of are no longer included with the self-assessment articles. The Allergy and Immunology office (414/272-6071) for answer self-assessment questions and answers, however, are printed sheets that should be completed and returned for receipt of for those wishing to assess themselves. If CME credit is Category I credit.

CME examination Identification No. 099152

Vercelli D, Geha RS. Regulation of IgE synthesis in humans: A tale of two signals. J ALLERGY CLIN IMMUNOL

1991;88:285-95.

Questions l-20

Choose correct answer(s) for each of the following questions:

1. The CD40 antigen is expressed on: a. Monocytes b. T cells c. B cells d. Mast cells e. Endothelial cells

2. Induction of IgE synthesis in B cells stimulated with IL-4 and anti-CD40 MAb or EBV results from: a. Isotype switching of sIgE- B cell precursors b. Expansion of an sIgE+ B cell population c. Expansion of sIgG+ B cell population

3, EBV infects and transforms: a. Monocytes b. B cells c. T cells d. Platelets

4. E Germ-line transcripts derive from: a. C, exons b. S, region c. I, exon d. S, region and the C, exons e. I, exon and the C. exons

5. The agents that regulate isotype switching mod- ulate: a. Translation of immunoglobulin heavy chain

genes b. Accessibility of specific S regions to the re-

combinase c. Glycosylation of IgE proteins d. Turnover of immunoglobulin

6. IL-4 by itself is able to induce: a. Mature E mRNA b. IgE isotype switching c. E Germ-line transcripts d. RNA transsplicing

7. Ongoing IgE synthesis in the HIE syndrome is: a. T cell dependent b. IL-4 dependent c . ILd-dependent d. T cell and lymphokine independent

8. Allergen-specific CD4 + T cell clones from atopic patients produce: a. High levels of IL-4 b. Low levels if IL-4 c. High levels of IL-2 d. Low levels of IL-2

9. CD40 is homologous to the receptor for: a. IL-2 b. TGF-P c. TNF-(w d. IL-6 e. IL-1

10. IgE synthesis by IL4-stimulated B cells requires endogenous: a. IL-2 b. IL-5 c. IL-3 d. IL-6

11. IgE synthesis requires: a. IL-4 b. IL-5 c. B cell-activating signal d. IL-4 and IL-5 e. IL-4 and a B cell-activating signal

12. IFN-y: a. Inhibits IgE synthesis b. Enhances IgE synthesis c. Is required for IgE synthesis d. Has no effect on IgE synthesis

13. IL-6 acts on: a. B cell commitment b. Early stage in B cell differentiation c. IgE isotype switching