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Integrinactivation
Basement Membrane(e.g. Collagen IV and Laminin)
Transitional Matrix(e.g. Fibronectin and Fibrinogen)
ATHEROGENESIS
Flk1
VE-cadherin
PECAM-1
α2β1
IKK
JNK
Rac
MKK4
?
NF-κB
PECAM-1
Permeability
Pro-inflammatorygene expression
ICAM-1VCAM-1
Flk1
VE-cadherin
α5β1, αvβ3
NADPHoxidase
NADPHoxidase
PI 3-kinase
PI 3-kinase
Rac
Src
PAK
PAKSrc
Discover more at abcam.com/integrin
Integrin Signaling in Shear Stress-inducedEndothelial Cell Dysfunction Pathway
Produced in collaboration with Dr. A. Wayne Orr, LSU Health Sciences Center.
Discover more at abcam.com/integrin
080-09/09-PW
Copyright © 2013 Abcam. All Rights Reserved.
Integrin Signaling in Shear Stress-induced Endothelial Cell Dysfunction PathwayRelated antibodiesAntibody Clonality Applications Host Species Reactivity Product Code
Collagen IV P IHC-P, IHC-FoFr, IP, WB, ELISA, IHC-Fr Rb Hu, Ms, Rat, Cow ab6586
Fibrinogen P IHC-P, ELISA, ICC/IF, FuncS Rb Hu, Ms, Rb ab34269
Fibronectin M AP, ICC/IF, IHC-Fr, IHC-P, RIA, WB Ms Hu, Ms, Rat, Chk, Cow, Dog, Pig ab6328
FLk1 / VEGF Receptor 2 P IP, Flow Cyt, IHC-P, ICC/IF, IHC-Fr Rb Hu, Ms, Rat, Cow, Dog ab2349
ICAM1 M ELISA, Flow Cyt, IP, WB Ms Hu, Rat, Cow ab2213
IKK alpha + IKK beta P IHC-P, ELISA Rb Hu, Ms ab62481
Integrin alpha 2 M IP, Flow Cyt, IHC-P, IHC-Fr Ms Hu ab10800
Integrin alpha 2 + beta 1 M Flow Cyt, IP, WB, ELISA, ICC/IF, IHC-Fr Ms Hu ab30483
Integrin alpha 5 M Flow Cyt, ICC/IF, IP Ms Hu ab6131
Integrin alpha 5 + beta 1 M Flow Cyt, IP, Inhib, WB, IHC-Fr Rat Ms ab77981
Integrin alpha v M ELISA, Flow Cyt, ICC/IF, IHC-P, IP Ms Hu ab16821
Integrin alpha v + beta 3 M BL, IP, IHC-Fr Ms Hu ab78289
Integrin beta 1 M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IHC-P, WB Rb Hu, Ms, Rat ab52971
Integrin beta 3 M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, Inhib, WB Ms Hu ab7167
JNK1+JNK2 (phospho T183+Y185) P IHC-P, WB, ICC/IF, IHC-Fr Rb Hu, Ms, Predicted: Many ab4821
JNK1+JNK2+JNK3 P WB, ELISA Rb Hu, Ms, Rat ab59227
Laminin P Dot, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP Rb Hu, Ms, Mamm, Amph, Dog, Pig, Rept ab11575
MKK4 / MEK4 (phospho S80) P IHC-P, WB, ELISA Rb Hu, Ms, Rat ab39403
NFkB P ChIP, EMSA, ICC/IF, IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rat ab7970
PAK1 M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat ab40795
PAK1+PAK2+PAK3 P IHC-P, ELISA Rb Hu, Ms, Rat ab59248
PECAM1 / CD31 M IP, WB, ICC/IF Ms Hu, Ms, Rat ab24590
PECAM1 / CD31 (APC) M BL, Flow Cyt, IP, IHC-Fr Rat Ms ab25563
PI 3 Kinase p85 alpha M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Rat ab40755
Rac1 P IHC-P, WB, ICC/IF Rb Hu, Ms ab78139
Rac2 P IHC-P, WB, ELISA Gt Hu ab2244
Src P IHC-P, WB, ELISA, ICC/IF Rb Hu, Ms, Rat ab47405
Src (phospho Y529) M IP, WB, ICC/IF, Dot Rb Hu, Ms, Rat ab32078
VCAM1 (FITC) M Flow Cyt, ICC/IF, FuncS, IP Rat Ms ab24853
VE cadherin M Flow Cyt, IHC-P, IHC-Fr, IP, Neut, WB, P, ICC/IF Ms Hu, Ms ab7047
Product
highlights
Integrin alpha 5 (ab6131)Clonality Applications M Flow Cyt, ICC/IF, IP Host Species cross reactivity Ms Hu
Integrin beta 1 (ab52971)Clonality Applications P Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IHC-P, WBHost Species cross reactivity Rb Hu, Ms, Rat
PAK1 (ab40795)Clonality Applications M ICC/IF, IHC-P, IP, WB Host Species cross reactivity Rb Hu, Ms, Rat
Laminin (ab11575)Clonality Applications P Dot, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IPHost Species cross reactivity Rb Hu, Ms, Dog, Pig, Xl
Fibronectin (ab6328)Clonality Applications M AP, ICC/IF, IHC-Fr, IHC-P, RIA, WBHost Species cross reactivity Ms Hu, Ms, Rat, Chk, Cow, Dog, Pig