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INTERNATIONAL COLLABORATIVE
EXERCISES (ICE)
ICE
20
20
/2
Summary Report
ICE Round 2020/2
BIOLOGICAL SPECIMENS
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 1 of 62
ICE 2020/2-BS
Final summary report for ICE 2020/2 Biological Specimens Test Group
Original language: English
© United Nations, August 2021. All rights reserved, worldwide.
The designations employed and the presentation of material in this publication do not imply the expression of
any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any
country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries.
This publication has not been formally edited.
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 2 of 62
ICE 2020/2-BS
Acknowledgements
The Laboratory and Scientific Service (LSS) of the UNODC, headed by Dr. Justice Tettey, wishes to express its appreciation and thanks to all laboratories for participating in the International Collaborative Exercises (ICE) round 2020/2. The valuable comments and contribution from the following members of the International Panel of Forensic Experts are gratefully acknowledged: Mr. Benoit Archambault, Health Canada, Canada Mr. Elvio Dias Botelho, Brazilian Federal Police, Brazil Prof. Heesun Chung, Sungkyunkwan University, Republic of Korea Prof. Niamh Nic Daéid, University of Dundee, Scotland, UK Mr. Scott Oulton, Drug Enforcement Administration, USA Ms. Catherine Quinn, Victoria Police, Australia Prof. Franco Tagliaro, University of Verona, Italy Dr. Angeline Tiong Whei Yap, Health Sciences Authority, Singapore In addition, LSS would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme. The ICE is coordinated by Ms. Yen Ling Wong, Scientific Affairs Officer, a staff member of LSS. The assistance and the contributions of the following LSS staff members are gratefully acknowledged. Dr. Conor Crean, Scientific Affairs Officer Mr. Joao Rodrigues, Scientific Affairs Officer Ms. Romana Luger, Research Assistant Dr. Gerd Krapf, Laboratory Technician Mr. Michael Bell, Laboratory Technician Ms. Mikaela Edwards, Laboratory Team Assistant For additional information or comments, please contact: Ms. Yen Ling Wong ICE Coordinator Scientific Affairs Officer Laboratory and Scientific Service UNODC, Vienna International Centre Wagramer Strasse 5, P.O. Box 500 A-1400, Vienna, AUSTRIA Email: [email protected]
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 3 of 62
ICE 2020/2-BS
Contents
1. Codes and Abbreviations ..............................................................................................................................4
2. Test samples information .............................................................................................................................5
3. Introduction ..................................................................................................................................................6
4. Comments from the International Panel of Forensic Experts ......................................................................7
5. New Psychoactive Substances (NPS) reported .............................................................................................9
6. Summary of responses for Test Sample-1 ................................................................................................. 11
7. Summary of responses for Test Sample-2 ................................................................................................. 12
8. Summary of responses for Test Sample-3 ................................................................................................. 17
9. Summary of responses for Test Sample-4 ................................................................................................. 21
10. ANNEX 1: Participants’ results for Test Sample-1 ..................................................................................... 25
11. ANNEX 2: Participants’ results for Test Sample-2 ..................................................................................... 34
12. ANNEX 3: Participants’ results for Test Sample-3 ..................................................................................... 44
13. ANNEX 4: Participants’ results for Test Sample-4 ..................................................................................... 53
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 4 of 62
ICE 2020/2-BS
1. Codes and Abbreviations (+) “positive” Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates
that a positive reaction was obtained.
(-) “negative” Indicates that the analyte is not identified.
(ANP) Analysis not performed.
Tech Code Name
100 Agglutination techniques
110 Enzyme immunoassay techniques
120 Fluorescence polarization immunoassay
130 Radioimmunoassay
140 Colorimetric reactions
141 Marquis test
142 Cobalt thiocyanate test
150 Thin layer chromatography (TLC)
160 High/ultra high performance liquid chromatography with ultraviolet-visible spectroscopy (HPLC/UPLC)
161 High/ultra high performance liquid chromatography with diode array detection (HPLC-DAD or UPLC-DAD)*
170 Gas chromatography with nitrogen-phosphorous detection (GC-NPD)
171 Gas chromatography with flame ionization detection (GC-FID)
172 Gas chromatography with electron capture detection (GC-ECD)
180 Gas chromatography with mass spectrometry (GC-MS)
190 Fourier transform infrared spectrometry (FTIR)
200 Spectrophotometry (visible, UV)
210 Others
211 Nuclear magnetic resonance spectroscopy (NMR)
220 Microcrystal test
230 Liquid chromatography with mass spectrometry (LC-MS)
231 Liquid chromatography with tandem mass spectrometry (LC-MS/MS)
*similar to 160
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 5 of 62
ICE 2020/2-BS
2. Test samples information The following four (4) test samples for the Biological Specimens test group were prepared by a private company under subcontract with the Laboratory and Scientific Service, UNODC: Test Sample-1 (BS-1) To prepare BS-1, urine was spiked with an aqueous solution of morphine sulphate. The spiked urine was dispensed in 25 mL aliquots and lyophilised. Test Sample-2 (BS-2) To prepare BS-2, urine was spiked with an ethanolic solution of buprenorphine hydrochloride and a methanolic solution of norbuprenorphine to achieve final concentrations of 920 ng base/mL for both analytes. The spiked urine was dispensed in 25 mL aliquots and lyophilised. Test Sample-3 (BS-3) To prepare BS-3, urine was spiked with a methanolic solution of nordazepam to achieve a final concentration of 460 ng base/mL. The spiked urine was dispensed in 25 mL aliquots and lyophilised. Test Sample-4 (BS-4) To prepare BS-4, urine was spiked with a methanolic solution of MDMA hydrochloride to achieve a final concentration of 860 ng base/mL. The spiked urine was dispensed in 25 mL aliquots and lyophilised. All test samples were prepared from urine free of all major groups of abused drugs. Metabolites of caffeine may be present. No preservatives were added to the urine samples. All analytes spiked into the test samples were commercially sourced reference standards.
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 6 of 62
ICE 2020/2-BS
3. Introduction An important element of the UNODC International Quality Assurance Programme (IQAP) is the
implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both
developing and developed countries to continuously monitor their performance in drug testing on a truly
global scale. This report provides information on analytical results of laboratories participating in the Biological
Specimens (BS) test group. In order to maintain confidentiality, the participating laboratories have been
assigned random “Round Codes”, which change every round.
The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential
report is provided to each laboratory on its own performance. The overall analytical results are reviewed by
the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises,
and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of
the performance and capacity of participating laboratories and enable UNODC to tailor technical support in
the laboratory sector for greatest impact.
The ICE programme is a UNODC mandated activity and is implemented through regular budget funds and
through the UNODC Global Scientific and Forensic Programme – Support Project (GLOU54), which
operationalizes the forensic aspects of the UNODC Thematic Programme on Research, Trend Analysis and
Forensics". Figure 1 shows the growth of the programme in the last 10 years for both the Seized Materials (SM)
and the Biological Specimens (BS) test groups.
Note: Reduced participation rate in rounds 2020/1 and 2020/2 resulted from the challenges arising from the
COVID-19 pandemic.
Figure 1. Growth of the ICE programme (as of 5 August 2021)
100 102
116
129 132 131
151159
179173
184 185
204 204 204195
222 226
208
179
3747
5462 58 62
72 7486 90
95 92 96 97 9388
101106
96
84
0
50
100
150
200
250
No
. of
lab
ora
tori
es
ICE round
SM BS
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 7 of 62
ICE 2020/2-BS
4. Comments from the International Panel of Forensic Experts
4.1 Participation of Laboratories in ICE round 2020/2
In the 2020/2 round of the ICE programme, results were submitted within both the Seized Materials (SM)
and Biological Specimens (BS) test groups by 225 laboratories in 66 countries. Within the BS test group,
results were submitted by 84 participating laboratories from 39 countries and within the SM test group,
there were 179 laboratories from 57 countries. The reduced participation rate of this round and the
previous round is mainly due to shipping restrictions to a number of countries experiencing on-going
COVID-19 pandemic.
4.2 Qualitative Analysis
The analytical techniques most commonly used for screening of test samples in the BS test group were
immunoassays (61% of participants). GC-MS (79% of participants) was the most commonly used technique
for identification/confirmation of the components in the test samples, followed by LC-MS/MS (48% of
participants). The results for the qualitative identification of the sample components in the BS test group,
the number of false positive/negative results and the analyses not performed are shown in Table 1.
Table 1. Performance of participants in the 2020/2 round of ICE.
Test sample BS-1*
(Morphine)
BS-2 BS-3 BS-4
(Buprenorphine) (Norbuprenorphine) (Nordazepam) (MDMA)
Correct identification by participants
61.9% 78.6% 56.0%
90.5% 90.5% At least 1 component: 79.8%
Number of false positives
2 3 6 7
Number of false negatives
20 6 3 7
Number of analyses not performed
12 11 5 1
Overall, only a total of 45% of participants were able to identify all 4 test samples correctly. This was mainly
due to the low concentration of morphine (69 ng/mL) in test sample BS-1* which was below cut-offs set by
laboratories, resulting in 20 participants obtaining false negatives for this test sample. With regards to false
positive results, there were a total of 18 false positive results, which is a slight decrease in number
compared to the previous round. Nonetheless, laboratories reporting false positive or false negative results
should investigate the reasons for this and corrective actions should be taken as soon as possible in order
to continuously improve performance. A number of participants did not perform analysis on test samples
BS-1 and BS-2 containing morphine and buprenorphine/norbuprenorphine, respectively. ICE participants
are reminded that test samples can contain any of the substances in the ICE menu and as such if methods
are available, all substances should be considered.
Note: *The concentration of morphine in test sample 2020/1/BS-1 was found to differ considerably from the stated amount
prepared by a private contracted company. Hence for this test sample, only qualitative results were evaluated.
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 8 of 62
ICE 2020/2-BS
4.3 Quantitative Analysis
The test samples in the BS group for the 2020/2 round of ICE contained a total of four components for
quantification and 38 (45%) laboratories performed quantification. Of these laboratories, it is encouraging
to note that 87% of laboratories quantified at least two components and 45% performed quantification of
all four components. LC-MS/MS, used by 53% of participants, was the most commonly used technique for
quantitation, followed by GC-MS, which was used by 50% of participants. z-Scores obtained by participants
in quantification are shown in Table 2 below (percentage + no. of labs indicated).
Table 2. Quantitative performance of participants in the 2020/2 round of ICE.
In general, the performance of laboratories improved with more laboratories achieving acceptable z-scores.
According to the recommendations in ISO 13528:2015, an unacceptable z-score is considered to give an
action signal and a questionable z-score is considered to give a warning signal. A single action signal or
warning signal in two successive rounds shall be taken that an anomaly has occurred that requires
investigation. Participants with z-scores outside acceptable limits should review their quantification
procedures as soon as possible.
The following 2 laboratories obtained a single action signal or warning signal in the two successive rounds
of 2020/1 and 2020/2 and shall take this as anomaly, which requires further investigation: U4DAAJ and
VUASIY.
One laboratory, U4DAAJ, that obtained a single action or warning signal in ICE rounds 2019/2 and 2020/1,
was also found to obtained action or warning signals in this round.
Laboratories that need to perform quantitation routinely are encouraged to participate regularly in
external proficiency testing or collaborative exercises such as the ICE programme. This will enable
laboratories to assess the quality of their quantitative methods through the z-score values obtained.
Laboratories reporting false positive or false negative results should investigate the root causes and
corrective actions taken promptly in order to continuously improve performance. Participation in the ICE
programme also helps in monitoring the effect of corrective actions.
z-score
Test sample
BS-2 (920 ng/mL
Buprenorphine)
BS-2 (920 ng/mL
Norbuprenorphine)
BS-3 (460 ng/mL
Nordazepam)
BS-4 (860 ng/mL MDMA)
|z| ≤ 2.00, acceptable
89.3% (25) 95.0% (19) 88.2% (30) 94.1% (32)
2.00 < |z| < 3.00, questionable
3.6% (1) 0.0% (0) 2.9% (1) 5.9% (2)
|z| ≥ 3.00, unacceptable
7.1% (2) 5.0% (1) 8.9% (3) 0.0% (0)
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 9 of 62
ICE 2020/2-BS
5. New Psychoactive Substances (NPS) reported During the 2020/2 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 63 reports of 45 substances. As shown in Figure 2, the most commonly reported substances were synthetic cannabinoids (27%) and substances belonging to a group known as “other substances” (27%). These substances are structurally diverse and do not fit into the categories mentioned in the UNODC Early Warning Advisory on NPS.
Figure 2. Distribution of classes of NPS reported by ICE laboratories during the 2020/2 round of ICE
In terms of the mode of action of the NPS reported by ICE participants, the predominant substances reported were synthetic cannabinoid receptor agonists (27%) followed by dissociatives (18%) and hallucinogens (18%) as shown in Figure 3.
Figure 3. Distribution of NPS reported by ICE participants in the 2020/2 round of ICE according to the
mode of action
27%
13%
27%
9%
17%
5% 2%
Synthetic cannabinoids
Synthetic cathinones
Other substances
Phenethylamines
Phencyclidine-type substances
Tryptamines
Plant-based substances
27%
15%
18%
6%
18%
16%
Synthetic cannabinoid receptor agonists
Stimulants
Hallucinogens
Opioids
Dissociatives
Sedatives/Hypnotics
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 10 of 62
ICE 2020/2-BS
The substances most often reported by ICE participants were ketamine, MDMB-4en-PINACA and
flubromazolam. While ketamine is currently not under international control, MDMB-4en-PINACA and
flubromazolam were placed under international control under Schedule II and IV, respectively, of the
Convention on Psychotropic Substances, 1971, at the 64th session of the Commission on Narcotic Drugs
in April 2021. These decisions will come into force on 7 December 2021.
Name Convention Schedule Effective date of
international control
Flubromazolam 8-bromo-6-(2-fluorophenyl)-1-methyl-4H-benzo[f][1,2,4]-triazolo[4,3-a][1,4]diazepine
1971 IV 7th December 2021
Ketamine 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
Currently not under international control
MDMB-4en-PINACA methyl 3,3-dimethyl-2-(1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido)butanoate
1971 II 7th December 2021
For further details on these substances and others reported to the UNODC Early Warning Advisory, ICE
participants can log on to the UNODC ICE portal, www.unodc.org/lss, and select the icon for the Early
Warning Advisory on New Psychoactive substances as shown below.
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 11 of 62
ICE 2020/2-BS
6. Summary of responses for Test Sample-1
The summary of responses of all 84 participating laboratories for the identification of BS-1:
Correct identification of Test Sample-1:
False positives for Test Sample-1 (technique(s) used):
False negatives for Test Sample-1 with respect to Morphine (technique(s) used):
Round Code Tech Code Round Code Tech Code 55O3RU 180, 190 J0E7UI 180 5ZE565 230 JFDHCS 180
AXDW2N 180 JMIFJG 180 BIDPSO 180, 231 JOXEMT 231
BOCUHG 231 LCXPWI 150, 180 DEEJ5E 180 O66Z5F 150 DZYOGL 180 REBSFB 180 EENW2Z 180 SW25NX 231 GGCGG3 231 T7ZWMT 180, 231 GRIPEY 180 VUASIY 180
Analysis not performed for Test Sample-1 with respect to Morphine:
6UPYUO, 8Q9HHM, 9P9B97, AQAYT9, HJCDJ2, JMJLE1, LAAAAA, MCZMMA, PDDDDD, PJ6NX9,
Q33R30 and W8VSHC.
Frequency of use of screening, identification and quantification techniques:
Test Sample 1: Response Summary
No of Participants: 84 (Qualitative); 0 (Quantitative)
Technique 100 110 142 150 160 161 170 180 190 210 230 231
Screening (No.) 1 50 1 0 0 1 0 18 0 1 6 14
(%) 1.2 59.5 1.2 0.0 0.0 1.2 0.0 21.4 0.0 1.2 7.1 16.7
Identification (No.) 0 5 0 4 1 5 1 66 1 1 10 40
(%) 0.0 6.0 0.0 4.8 1.2 6.0 1.2 78.6 1.2 1.2 11.9 47.6
Quantification (No.) 0 0 0 0 0 0 0 0 0 0 0 0
(%) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Substance Name Number of laboratories Percentage Morphine 52 61.9%
Round Code Substance Reported Tech Code 55O3RU Benzodiazepine 180, 190 LHZ8CT Benzoylecgonine, oxymorphone 231
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
Page 12 of 62
ICE 2020/2-BS
7. Summary of responses for Test Sample-2
The summary of responses of all 84 participating laboratories for the identification of BS-2:
Correct identification of Test Sample-2:
False positives for Test Sample-2 (technique(s) used):
False negatives for Test Sample-2 with respect to Buprenorphine (and/or metabolite)
(technique(s) used):
Round Code Tech Code
55O3RU 180, 190 CAAEEE 180, 230 DZYOGL 180 GRIPEY 180 U4DAAJ 180, 231 UOKKUT 180
Analysis not performed for Test Sample-2 with respect to Buprenorphine (and metabolite):
5CHXK3, 5ZE565, 6UPYUO, 9NNWNO, 9P9B97, FCUPDY, GTNYPU, PJ6NX9, QDFCD8, REBSFB and VUASIY
Frequency of use of screening, identification and quantification techniques:
Test Sample 2: Response Summary
No of Participants: 84 (Qualitative); 28 (Quantitative)
Technique 100 110 142 150 160 161 170 180 190 210 230 231
Screening (No.) 1 50 1 0 0 1 0 18 0 1 6 14
(%) 1.2 59.5 1.2 0.0 0.0 1.2 0.0 21.4 0.0 1.2 7.1 16.7
Identification (No.) 0 5 0 4 1 5 1 66 1 1 10 40
(%) 0.0 6.0 0.0 4.8 1.2 6.0 1.2 78.6 1.2 1.2 11.9 47.6
Quantification (No.) 0 0 0 0 0 0 0 7 0 1 1 16
(%) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.0 0.0 3.6 3.6 57.1
Substance Name Number of laboratories Percentage Buprenorphine 66 78.6%
Norbuprenorphine 47 56.0% At least one component 67 79.8%
Round Code Substance Reported Tech Code
55O3RU Benzodiazepine 180, 190
B3EBPD Nordazepam 230
CAAEEE Paracetamol 180, 230
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
Round: 2020/2
Substance: BS-2; Buprenorphine
-2.4
5
-1.5
5
-1.4
5 -1.0
9
-0.8
4
-0.7
8
-0.7
8 -0.3
7
-0.3
0
-0.2
8
-0.1
6
-0.1
4
-0.1
3
-0.1
2
-0.1
0
0.0
4
0.0
5
0.1
6
0.3
4
0.3
9
0.5
4
0.5
5
0.5
7 0.9
6 1.4
5 1.7
6
6.9
8
16
.26
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
90
YC0
Z
LHZ8
CT
GG
CG
G3
EEN
W2
Z
JW3
GX
I
6SJ
6SS
SW2
5N
X
DM
UL5
S
BO
CU
HG
MC
ZMM
A
8V
4YG
Y
8H
6FT
6
LGN
UV
H
VLN
X9
X
YYX
EXU
HC
HYZ
Y
MFP
KC
L
0R
3C
HB
AP
EFD
F
HJC
DJ2
T7ZW
MT
DEE
J5E
AQ
AYT
9
66
6K
D9
E66
6O
G
X2
CTX
X
LPN
77
A
QM
PZY
H
Z-scores can be interpreted by participants in line with ISO 13528:2015*, section 9.4.2 as follows: IzI ≤ 2.00 is considered to be acceptable 2.00 < IzI < 3.00 is considered to be questionable (or warning signal) IzI ≥ 3.00 is considered to be unacceptable (or action signal)
A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occurred that requires investigation.
Robust mean: 885 ng/mL Robust SD: 287 ng/mL Robust CV%: 32.4%
Prepared conc.: 920 ng/mL Max reported: 5549 ng/mL Min reported: 182 ng/mL No of labs: 28
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
Round: 2020/2
Substance: BS-2; Norbuprenorphine
-1.5
7
-1.5
7
-0.9
2
-0.9
2 -0.5
6
-0.5
3
-0.3
0
-0.2
5
-0.2
1
-0.1
3
0.0
1
0.1
2
0.1
4
0.2
3 0.5
9
0.6
3
0.6
8
1.4
1 1.8
5
10
.05
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
GG
CG
G3
90
YC0
Z
EEN
W2
Z
DM
UL5
S
0R
3C
HB
8V
4YG
Y
6SJ
6SS
LHZ8
CT
T7ZW
MT
BO
CU
HG
JW3
GX
I
SW2
5N
X
MC
ZMM
A
YYX
EXU
HJC
DJ2
HC
HYZ
Y
LGN
UV
H
X2
CTX
X
AP
EFD
F
LPN
77
A
Z-scores can be interpreted by participants in line with ISO 13528:2015*, section 9.4.2 as follows: IzI ≤ 2.00 is considered to be acceptable 2.00 < IzI < 3.00 is considered to be questionable (or warning signal) IzI ≥ 3.00 is considered to be unacceptable (or action signal)
A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occurred that requires investigation.
Robust mean: 841 ng/mL Robust SD: 403 ng/mL Robust CV%: 47.9%
Prepared conc.: 920 ng/mL Max reported: 4889 ng/mL Min reported: 208 ng/mL No of labs: 20
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
Copyright © 2021 UNODC
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
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ICE 2020/2-BS
Z-Scores for Test Sample-2
Code
Buprenorphine
Code
Norbuprenorphine
Concentration (ng/ml)
Deviation from robust
average (ng/ml)
z-score Concentration (ng/ml)
Deviation from robust
average (ng/ml)
z-score
90YC0Z 182 -703 -2.45 GGCGG3 208 -633 -1.57
LHZ8CT 440 -445 -1.55 90YC0Z 208 -633 -1.57
GGCGG3 470 -415 -1.45 EENW2Z 469 -372 -0.92
EENW2Z 571 -314 -1.09 DMUL5S 470 -371 -0.92
JW3GXI 644 -241 -0.84 0R3CHB 615 -226 -0.56
6SJ6SS 660 -225 -0.78 8V4YGY 629 -212 -0.53
SW25NX 662 -223 -0.78 6SJ6SS 720 -121 -0.30
DMUL5S 780 -105 -0.37 LHZ8CT 740 -101 -0.25
BOCUHG 800 -85 -0.30 T7ZWMT 755 -86 -0.21
MCZMMA 806 -79 -0.28 BOCUHG 790 -51 -0.13
8V4YGY 840 -45 -0.16 JW3GXI 846 5 0.01
8H6FT6 846 -39 -0.14 SW25NX 889 48 0.12
LGNUVH 849 -36 -0.13 MCZMMA 897 56 0.14
VLNX9X 850 -35 -0.12 YYXEXU 934 93 0.23
YYXEXU 855 -30 -0.10 HJCDJ2 1079 238 0.59
HCHYZY 896 11 0.04 HCHYZY 1094 253 0.63
MFPKCL 900 15 0.05 LGNUVH 1114 273 0.68
0R3CHB 930 45 0.16 X2CTXX 1410 569 1.41
APEFDF 982 97 0.34 APEFDF 1587 746 1.85
HJCDJ2 997 112 0.39 LPN77A 4889 4048 10.05
T7ZWMT 1039 154 0.54 DEEJ5E 1042 157 0.55 AQAYT9 1047 162 0.57 666KD9 1159 274 0.96 E666OG 1300 415 1.45 X2CTXX 1390 505 1.76 LPN77A 2887 2002 6.98 QMPZYH 5549 4664 16.26
International Collaborative Exercises (ICE)Summary report 2020/2- Biological Specimens
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ICE 2020/2-BS
8. Summary of responses for Test Sample-3
The summary of responses of all 84 participating laboratories for the identification of BS-3:
Correct identification of Test Sample-3:
False positives for Test Sample-3 (technique(s) used):
False negatives for Test Sample-3 with respect to Nordazepam (technique(s) used):
Round Code Tech Code 55O3RU 180, 190 O66Z5F 150 XEHBYJ 150
Analysis not performed for Test Sample-3 with respect to Nordazepam:
6SOTQX, 6UPYUO, 8Q9HHM, GTNYPU and LHZ8CT
Frequency of use of screening, identification and quantification techniques:
Test Sample 3: Response Summary
No of Participants: 84 (Qualitative); 34 (Quantitative)
Technique 100 110 142 150 160 161 170 180 190 210 230 231
Screening (No.) 1 50 1 0 0 1 0 18 0 1 6 14
(%) 1.2 59.5 1.2 0.0 0.0 1.2 0.0 21.4 0.0 1.2 7.1 16.7
Identification (No.) 0 5 0 4 1 5 1 66 1 1 10 40
(%) 0.0 6.0 0.0 4.8 1.2 6.0 1.2 78.6 1.2 1.2 11.9 47.6
Quantification (No.) 0 0 0 0 1 1 0 14 0 0 1 14
(%) 0.0 0.0 0.0 0.0 2.9 2.9 0.0 41.2 0.0 0.0 2.9 41.2
Substance Name Number of laboratories Percentage Nordazepam 76 90.5%
Round Code Substance Reported Tech Code 55O3RU Benzenethanamine derivative 180, 190
B3EBPD Buprenorphine 230
LHZ8CT MDPV 180, 231
O66Z5F Temazepam 150
VUASIY Alprazolam 180
XEHBYJ Temazepam 150
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
Round: 2020/2
Substance: BS-3; Nordazepam
Z-scores can be interpreted by participants in line with ISO 13528:2015*, section 9.4.2 as follows: IzI ≤ 2.00 is considered to be acceptable 2.00 < IzI < 3.00 is considered to be questionable (or warning signal) IzI ≥ 3.00 is considered to be unacceptable (or action signal)
A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occurred that requires investigation.
Robust mean: 461 ng/mL Robust SD: 175 ng/mL Robust CV%: 37.9%
Prepared conc.: 460 ng/mL Max reported: 6430 ng/mL Min reported: 217 ng/mL No of labs: 34
-1.4
0
-1.2
1
-1.0
1
-0.9
2
-0.9
2
-0.7
8
-0.7
6
-0.7
5
-0.7
5
-0.5
2
-0.5
2
-0.5
0
-0.3
9
-0.3
9
-0.3
4
-0.2
8
-0.2
4
-0.2
4
-0.1
1
-0.1
1
-0.1
1
-0.0
3
0.1
6
0.2
9
0.3
3 0.5
9 0.8
5 1.0
8 1.4
7 1.8
0
2.6
5
3.3
6
7.3
8
34
.11
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
8V
4YG
Y
BO
CU
HG
QD
FCD
8
0R
3C
HB
T7ZW
MT
QM
PZY
H
SW2
5N
X
REB
SFB
6SJ
6SS
LGN
UV
H
8H
6FT
6
RM
YQA
R
JMJL
E1
JW3
GX
I
AP
EFD
F
90
YC0
Z
GG
CG
G3
VLN
X9
X
MFP
KC
L
HC
HYZ
Y
66
6K
D9
YYX
EXU
8T2
0G
0
AQ
AYT
9
EEN
W2
Z
LPN
77
A
DM
UL5
S
E66
6O
G
DEE
J5E
X2
CTX
X
HJC
DJ2
DZY
OG
L
U4
DA
AJ
VU
ASI
Y
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Copyright © 2021 UNODC
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
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Copyright © 2021 UNODC
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ICE 2020/2-BS
Z-Scores for Test Sample-3
Code
Nordazepam
Concentration (ng/ml)
Deviation from robust
average (ng/ml)
z-score
8V4YGY 217 -244 -1.40
BOCUHG 250 -211 -1.21
QDFCD8 285 -176 -1.01
0R3CHB 300 -161 -0.92
T7ZWMT 301 -160 -0.92
QMPZYH 325 -136 -0.78
SW25NX 328 -133 -0.76
REBSFB 330 -131 -0.75
6SJ6SS 330 -131 -0.75
LGNUVH 370 -91 -0.52
8H6FT6 370 -91 -0.52
RMYQAR 374 -87 -0.50
JMJLE1 393 -68 -0.39
JW3GXI 393 -68 -0.39
APEFDF 402 -59 -0.34
90YC0Z 413 -48 -0.28
GGCGG3 420 -41 -0.24
VLNX9X 420 -41 -0.24
MFPKCL 442 -19 -0.11
HCHYZY 442 -19 -0.11
666KD9 442 -19 -0.11
YYXEXU 456 -5 -0.03
8T20G0 490 29 0.16
AQAYT9 512 51 0.29
EENW2Z 518 57 0.33
LPN77A 565 104 0.59
DMUL5S 610 149 0.85
E666OG 650 189 1.08
DEEJ5E 719 258 1.47
X2CTXX 776 315 1.80
HJCDJ2 925 464 2.65
DZYOGL 1050 589 3.36
U4DAAJ 1753 1292 7.38
VUASIY 6430 5969 34.11
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ICE 2020/2-BS
9. Summary of responses for Test Sample-4
The summary of responses of all 84 participating laboratories for the identification of BS-4:
Correct identification of Test Sample-4:
False positives for Test Sample-4 (technique(s) used):
False negatives for Test Sample-4 with respect to MDMA (technique(s) used):
Round Code Tech Code 55O3RU 180, 190 AN3H29 180 DZYOGL 180 EENW2Z 180 GRIPEY 180 GVGEP9 230 O2A2BN 210
Analysis not performed for Test Sample-4 with respect to MDMA:
FCUPDY
Frequency of use of screening, identification and quantification techniques:
Test Sample 4: Response Summary
No of Participants: 84 (Qualitative); 34 (Quantitative)
Technique 100 110 142 150 160 161 170 180 190 210 230 231
Screening (No.) 1 50 1 0 0 1 0 18 0 1 6 14
(%) 1.2 59.5 1.2 0.0 0.0 1.2 0.0 21.4 0.0 1.2 7.1 16.7
Identification (No.) 0 5 0 4 1 5 1 66 1 1 10 40
(%) 0.0 6.0 0.0 4.8 1.2 6.0 1.2 78.6 1.2 1.2 11.9 47.6
Quantification (No.) 0 1 0 0 0 0 0 13 0 0 1 16
(%) 0.0 2.9 0.0 0.0 0.0 0.0 0.0 38.2 0.0 0.0 2.9 47.1
Substance Name Number of laboratories Percentage MDMA 76 90.5%
Round Code Substance Reported Tech Code 55O3RU Opiates 180, 190
CAAEEE Quetiapine 180, 230
DZYOGL Amfetamine 180
GRIPEY Metamfetamine 180
GTNYPU 11-nor-∆9-THC-9-carboxylic acid, THC 180
GVGEP9 Morphine 230
O2A2BN Mephedrone 210
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Copyright © 2021 UNODC
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
Round: 2020/2
Substance: BS-4; MDMA
Z-scores can be interpreted by participants in line with ISO 13528:2015*, section 9.4.2 as follows: IzI ≤ 2.00 is considered to be acceptable 2.00 < IzI < 3.00 is considered to be questionable (or warning signal) IzI ≥ 3.00 is considered to be unacceptable (or action signal)
A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occurred that requires investigation.
Robust mean: 880 ng/mL Robust SD: 257 ng/mL Robust CV%: 29.2%
Prepared conc.: 860 ng/mL Max reported: 1373 ng/mL Min reported: 189 ng/mL No of labs: 34
-2.6
9 -2.2
4
-1.4
8
-1.4
8
-1.2
1
-1.0
0 -0.6
2
-0.6
2
-0.6
1
-0.5
7
-0.4
4
-0.3
1
-0.2
2
-0.1
8
-0.1
5
-0.1
4
0.0
9
0.1
2
0.1
3
0.1
6
0.2
5
0.3
2
0.3
5
0.3
9
0.4
3
0.4
7 0.7
2
0.7
4 1.0
6
1.0
9 1.3
2
1.4
4
1.4
5 1.9
2
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
GG
CG
G3
QM
PZY
H
VU
ASI
Y
O6
6Z5
F
JW3
GX
I
66
6K
D9
6SO
TQX
LGN
UV
H
MC
ZMM
A
AQ
AYT
9
REB
SFB
6SJ
6SS
YYX
EXU
MFP
KC
L
U4
DA
AJ
8H
6FT
6
T7ZW
MT
8T2
0G
0
SW2
5N
X
90
YC0
Z
HJC
DJ2
HC
HYZ
Y
BO
CU
HG
DM
UL5
S
VLN
X9
X
LHZ8
CT
QD
FCD
8
X2
CTX
X
AP
EFD
F
DEE
J5E
0R
3C
HB
E66
6O
G
8V
4YG
Y
LPN
77
A
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ICE 2020/2-BS
Z-Score Report per Sample per Substance:
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ICE 2020/2-BS
Z-Scores for Test Sample-4
Code
MDMA
Concentration (ng/ml)
Deviation from robust
average (ng/ml)
z-score
GGCGG3 189 -691 -2.69
QMPZYH 305 -575 -2.24
VUASIY 500 -380 -1.48
O66Z5F 500 -380 -1.48
JW3GXI 569 -311 -1.21
666KD9 623 -257 -1.00
6SOTQX 720 -160 -0.62
LGNUVH 721 -159 -0.62
MCZMMA 724 -156 -0.61
AQAYT9 733 -147 -0.57
REBSFB 766 -114 -0.44
6SJ6SS 800 -80 -0.31
YYXEXU 824 -56 -0.22
MFPKCL 834 -46 -0.18
U4DAAJ 840 -40 -0.15
8H6FT6 844 -36 -0.14
T7ZWMT 902 22 0.09
8T20G0 910 30 0.12
SW25NX 914 34 0.13
90YC0Z 921 41 0.16
HJCDJ2 943 63 0.25
HCHYZY 961 81 0.32
BOCUHG 970 90 0.35
DMUL5S 980 100 0.39
VLNX9X 990 110 0.43
LHZ8CT 1000 120 0.47
QDFCD8 1065 185 0.72
X2CTXX 1070 190 0.74
APEFDF 1151 271 1.06
DEEJ5E 1160 280 1.09
0R3CHB 1220 340 1.32
E666OG 1250 370 1.44
8V4YGY 1252 372 1.45
LPN77A 1373 493 1.92
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ICE 2020/2-BS
10. ANNEX 1: Participants’ results for Test Sample-1
Identified substances for Test Sample 1
Code Identified Substances
0R3CHB Morphine
4GKVKL Morphine
55O3RU Caffeine and Benzodiazepine drug
5CHXK3 Morphine
666KD9 Morphine
6SJ6SS morphine
6SOTQX Morphine
6UPYUO NONE
7BXXXX Morphine
7V7ZMZ MORPHINE
8H6FT6 Morphine.
8Q9HHM Opiates
8T20G0 Morphine
90YC0Z morphine
9NNWNO Morphine
9NQ999 Morphine
AN3H29 Morphine
APEFDF morphine
AQAYT9 -
B3EBPD morphine
CAAEEE MORPHINE
DD6DWV morphine
DEEJ5E none
DMUL5S Morphine
E666OG Morphine
EENDPO Morphine
GTNYPU MORPHINE
GVGEP9 morphin
H8PYU5 Morphine
HCHYZY MORPHINE
HHT9JH morphine (total)
HJCDJ2 -
J0E7UI -
JFDHCS None
JOXEMT NO
JW3GXI Morphine
LCXPWI no
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ICE 2020/2-BS
Code Identified Substances
LGNUVH MORPHINE
LHZ8CT morphine, oxymorphone, benzoylecgonine
LPN77A morphine
MFPKCL Morphine
O2A2BN Morphine
O66Z5F none
PJ6NX9 None
PPQ4MN Morphine
QBVFBW Morphine
QDFCD8 Morphine
RMYQAR Morphine, total
T90OIT Morphine
TCP07X Morphine (Total)
U4DAAJ Morphine
UOKKUT Morphine (Total)
VLNX9X Morphine
W8VSHC No drugs
X2CTXX Morphine
XEHBYJ morphine traces
Y2QOYO Morphine
YYXEXU Morphine
ZQFW61 Morphine
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ICE 2020/2-BS
Statement of findings for Test Sample 1
Code Morphine (Total)
0R3CHB + -
4GKVKL + In the urine sample analyzed was detected and confirmed the presence of morphine.
55O3RU - On TLC & GC-MS examination, sample was found to contain Caffeine and Benzodiazepine drug.
5CHXK3 + Morphine was detected in sample BS-1
5ZE565 -
666KD9 + Specimen 2020/2/BS-1 is positive for drug Morphine
6SJ6SS +
6SOTQX + Consistent with use of morphine or heroin.
6UPYUO ANP SAMPLE 2020/2/BS-1 FOUND NOT TO CONTAIN ANY DRUGS
7BXXXX + Non-recent heroin/morphine use or prior consumption of food product containing poppy seeds
7V7ZMZ +
8H6FT6 + Probable medicinal use of morphine.
8Q9HHM ANP Presence of opiates in the sample 2020/2/BS-1. N.B: The analytical technique used is a semi-quantitaive technique; The opiates's amount found = 146 ng/ml. However, The analysis must be confirmed by a chromatographic method.
8T20G0 + Morphine results reported as free morphine
8V4YGY +
90YC0Z + this person consumed morphine or poppy seeds
9NNWNO +
9NQ999 + In the sample analyzed morphine was found.
9P9B97 ANP No common basic and acid drugs were detected in sample 2020/2/BS-1
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ICE 2020/2-BS
Code Morphine (Total)
A65OOQ +
AN3H29 + The coincidence between the relative retention time and mass-fragmentograms from a reference standard analyzed at the same conditions that the biological sample, indicates the detection of morphine and caffeine.
APEFDF + Presence of morphine
AQAYT9 ANP -
AXDW2N -
B3EBPD + morphine was found
BIDPSO - Examination and analyses performed on Exhibit "2020/2/BS1" did not reveal any positive findings of toxicological significance.
BOCUHG -
CAAEEE + CAFFEINE
DD6DWV + positive
DEEJ5E - blank control sample
DMUL5S +
DZYOGL -
E666OG + Morphine+ caffeine
EENDPO + Morphine was detected in BS-1 Sample.
EENW2Z - The simple not contains controlled drugs
FCUPDY +
GGCGG3 -
GRIPEY -
GTNYPU +
GVGEP9 +
H8PYU5 + It indicates the intake of morphine or the past use of heroin.
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ICE 2020/2-BS
Code Morphine (Total)
HCHYZY + La morphine est un analgésique (effet analgésique) de la famille des opiacés. La morphine est une molécule alcaloïde extraite de L'Opium. Elle agit directement sur le système nerveux central pour diminuer la sensation de douleur. elle est classée stupéfiant dans la plupart des pays
HHT9JH + in the urine morphine and caffeine were identified
HJCDJ2 ANP -
J0E7UI - we not found contain controlled drugs in BS-01
JFDHCS - No drugs that have been found in this test sample.
JMIFJG -
JMJLE1 ANP Drugs were not detected in 2020/2/BS-1
JOXEMT - no drug was identified - BLANK SAMPLE
JW3GXI + Morphine was detected in 2020/2/BS-1 sample.
KWLGGO +
LAAAAA ANP
LCXPWI -
LGNUVH + Morphine is detected in sample number one by LC-MS/MS
LHZ8CT + Negative (all analytes under cut-off)
LPN77A + morphine 60.03 ng/ml
MCZMMA ANP
MFPKCL +
O2A2BN +
O66Z5F -
PDDDDD ANP No drug detected
PJ6NX9 ANP None
PPQ4MN +
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ICE 2020/2-BS
Code Morphine (Total)
Q33R30 ANP No common drugs were detected in Sample 2020/2/BS-1.
QBVFBW +
QDFCD8 + Only free morphine was measured
QMPZYH +
REBSFB - Test sample 2020/2 BS-1 does not contain controlled drugs (Metamfetamine, Amfetamine, 11- nor-∆9-THC-9-carboxylic acid, 3,4-Methylenedioxymetamfetamine (MDMA), Morphine, Codeine, Oxazepam, Nordazepam and Benzoylecgonine), therefore Negative for Screening and Confirmatory analyses.
RMYQAR + Morphine, total ~0.09mg/L
SW25NX -
T7ZWMT - we only found traces of caffeine and theobromine
T90OIT + In sample BS-1 the drug morphine (total) was detected.
TCP07X +
U4DAAJ +
UOKKUT +
V4VTFQ +
VLNX9X +
VUASIY -
W8VSHC ANP
X2CTXX + 2020/2/BS-1 was containing morphine
XEHBYJ + Sample 2020/2/BS-1 contain morphine traces
Y2QOYO + Analytical Adverse Finding for Morphine
YYXEXU + Morphine
ZQFW61 + Morphine detected
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ICE 2020/2-BS
Identification methods for Test Sample 1
Analytical Technique Codes
Code 100 110 142 150 160 161 170 180 190 230 231 210
0R3CHB I SI
4GKVKL SI SI I
55O3RU SI I
5CHXK3 S SI SI
5ZE565 I SI
666KD9 S I I I
6SJ6SS S I SI
6SOTQX I SI
6UPYUO SI
7BXXXX SI SI
7V7ZMZ S I
8H6FT6 I I SI
8Q9HHM SI SI Immunochromatographic rapid tests
8T20G0 S I I
8V4YGY S I I
90YC0Z S I I
9NNWNO I
9NQ999 S I
9P9B97 I
A65OOQ S I I
AN3H29 I
APEFDF S S SI I
AQAYT9 S I
AXDW2N S I
B3EBPD I I S COBAS
BIDPSO I I
BOCUHG S SI
CAAEEE SI I
DD6DWV SI SI SFC-MS/MS
DEEJ5E SI
DMUL5S S I I
Legend: S ... used for Screening I ... used for Identification SI ... used for both
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ICE 2020/2-BS
Code 100 110 142 150 160 161 170 180 190 230 231 210
DZYOGL S I
E666OG S I SI
EENDPO I
EENW2Z S I
FCUPDY S I
GGCGG3 S I
GRIPEY S I
GTNYPU I
GVGEP9 S I
H8PYU5 S I SI
HCHYZY S I I
HHT9JH SI
HJCDJ2 S I I
J0E7UI S I
JFDHCS I I S Chemical immunoassay techniques
JMIFJG S I
JMJLE1 SI SI
JOXEMT SI
JW3GXI S I I I
KWLGGO S I I
LAAAAA S I SI
LCXPWI I I
LGNUVH S I I
LHZ8CT S I I
LPN77A I SI I
MCZMMA I I S KIMS and LC-Orbitrap MS
MFPKCL S I UHPLC-QTOF
O2A2BN SI LC TOFMS
O66Z5F I SI Dipro Drug Lab screen
PDDDDD I
PJ6NX9 I
PPQ4MN I
Q33R30 SI
QBVFBW S I I
QDFCD8 SI
QMPZYH S I I
REBSFB I S DTK
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ICE 2020/2-BS
Code 100 110 142 150 160 161 170 180 190 230 231 210
RMYQAR S I I
SW25NX S I
T7ZWMT SI I
T90OIT SI SI
TCP07X I
U4DAAJ I I S immunochromatographic test
UOKKUT S I
V4VTFQ SI S Immunochromatographic test
VLNX9X S I SI
VUASIY S I
W8VSHC S I
X2CTXX S I
XEHBYJ S I S Randox Biochip Technology
Y2QOYO SI SI
YYXEXU S I SI
ZQFW61 SI
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ICE 2020/2-BS
11. ANNEX 2: Participants’ results for Test Sample-2 Identified substances for Test Sample 2
Code Identified Substances
0R3CHB Buprenorphine, Norbuprenorphine
4GKVKL Buprenorphine, Norbuprenorphine
55O3RU Caffeine and Benzodiazepine drug
666KD9 Buprenorphine
6SJ6SS buprenorphine, norbuprenorphine
6SOTQX Buprenorphine and Norbuprenorphine
6UPYUO NONE
7BXXXX Buprenorphine/norbuprenorphine
7V7ZMZ BUPRENORPHINE, NORBUPRENORPHINE
8H6FT6 Buprenorphine, norbuprenorphine.
8Q9HHM Buprenorphine
8T20G0 Buprenorphine and norbuprenorphine
90YC0Z buprenorphine
9NQ999 Buprenorphine, Norbuprenorphine
AN3H29 Burprenorphine
APEFDF buprenorphine and norbuprenorphine
AQAYT9 Buprenorphine
AXDW2N Buprenorphine
B3EBPD Nordazepam
BIDPSO Buprenorphine and Norbuprenorphine
BOCUHG Buprenorphine and Norbuprenorphine
DD6DWV buprenorphine + norbuprenorphine
DEEJ5E buprenorphine
DMUL5S Buprenorphine, norbuprenorphine
E666OG Buprenorphine
EENDPO Burprenorphine
EENW2Z Buprenorphine
GGCGG3 buprenorphine, norbuprenorphine
GVGEP9 norbuprenorphine and buprenorphine
H8PYU5 Buprenorphine and Norbuprenorphine
HCHYZY Buprénorphine et norbuprénorphine
HHT9JH (nor)buprenorphine
HJCDJ2 Buprenorphine, Norbuprenorphine
J0E7UI buprenorphine and norbuprenorphine
JFDHCS Buprenophine and Norbuprenophine
JMIFJG Buprenorphine + Norbuprenorphine
JMJLE1 Buprenorphine
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ICE 2020/2-BS
Code Identified Substances
JOXEMT BUPRENORPHINE AND NORBUPRENORPHINE
JW3GXI Buprenorphine and norbuprenorphine
LAAAAA BUPRENORPHINE et NORBUPRENORPHINE
LCXPWI Buprenorphine, norbuprenorphine
LGNUVH BUPRENORPHINE and NORBUPRENORPHINE
LHZ8CT buprenorphine
LPN77A buprenorphine, norbuprenorphine
MCZMMA Buprenophine, Norburprenorphine
MFPKCL Buprenorphine and Norbuprenorphine
O2A2BN Buprenorphine
O66Z5F Buprenorfine
PDDDDD Buprenorphine
PJ6NX9 None
PPQ4MN Buprenorphine
Q33R30 Buprenorphine
QBVFBW Buprenorphine
RMYQAR Buprenorphine,Norbuprenorphine
SW25NX Norbup and Bup
T7ZWMT buprenorphine and norbuprenorphine
T90OIT Buprenorphine and norbuprenorphine
TCP07X Buprenorphine
VLNX9X Buprenorphine
W8VSHC Buprenorphine
X2CTXX Buprenorphine and Norbuprenorphine
XEHBYJ buprenorphine,norbuprenorphine
Y2QOYO Norbuprenorphine
YYXEXU Norbuprenorphine, Buprenorphine
ZQFW61 Buprenorphine and Norbuprenorphine
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ICE 2020/2-BS
Statement of findings for Test Sample 2
Code Buprenorphine Norbuprenorphine
0R3CHB + + -
4GKVKL + + In the urine sample analyzed was detected and confirmed the presence of Buprenorphine and Norbuprenorphine.
55O3RU - - On TLC & GC-MS examination, sample was found to contain Caffeine and Benzodiazepine drug.
5CHXK3 ANP ANP
5ZE565 ANP ANP
666KD9 + ANP Specimen 2020/2/BS-2 is positive for drug Buprenorphine
6SJ6SS + +
6SOTQX + + Concentrations of buprenorphine and metabolite were both >200ng/mL, these are high concentrations and consistent with use of buprenorphine.
6UPYUO ANP ANP SAMPLE 2020/2/BS-2 FOUND NOT TO CONTAIN ANY DRUGS
7BXXXX + + Immunoassay method used so neither analyte unequivocally confirmed (assay has cross-reactivity to both)
7V7ZMZ + +
8H6FT6 + + Use of buprenorphine.
8Q9HHM + ANP Presence of Buprenorphine in the sample 2020/2/BS-2. N.B: The analysis must be confirmed by a chromatographic method to quantify the found substance.
8T20G0 + + Only qualitative analysis has been carried out
8V4YGY + +
90YC0Z + + this person consumed buprenorphine
9NNWNO ANP ANP The substances that were tested are not present.
9NQ999 + + In the sample analyzed Buprenorphine and Norbuprenorphine were found.
9P9B97 ANP ANP No common basic and acid drugs were detected in sample 2020/2/BS-2
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Code Buprenorphine Norbuprenorphine
A65OOQ + +
AN3H29 + - The coincidence between the relative retention time and mass-fragmentograms from a reference standard analyzed at the same conditions that the biological sample, indicates the detection of Burprenorphine and caffeine.
APEFDF + + Presence of buprenorphine and its metabolite norbuprenorphine
AQAYT9 + ANP Buprenorphine was found qualitatively using GC-MS then confirmed quantitively using LC/MS/MS
AXDW2N + ANP Buprenorphine was identified by GC/MS analysis
B3EBPD + - nordazepam was found
BIDPSO + + Buprenorphine is an opioid medication. Norbuprenorphine is a metabolite of buprenorphine.
BOCUHG + + Positive to Buprenorphine and its metabolite Norbuprenorphine
CAAEEE - - CAFFEINE, PARACETAMOL
DD6DWV + + positive
DEEJ5E + ANP subject in substitution treatment
DMUL5S + +
DZYOGL - -
E666OG + ANP Buprenorphine
EENDPO + ANP Burprenorphine was detected in BS-2 Sample.
EENW2Z + + The simple contains Buprenorphine and Norbuprenorphine
FCUPDY ANP ANP
GGCGG3 + + recent intake of buprenorphine.No information on the conditions of the subject at the time of sample collection.
GRIPEY - -
GTNYPU ANP ANP
GVGEP9 + +
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Code Buprenorphine Norbuprenorphine
H8PYU5 + + It indicates the intake of buprenorphine. Norbuprenorphine is the metabolite of buprenorphine.
HCHYZY + + La buprénorphine (DCI) est un médicament, agoniste partiel (ou agoniste-antagoniste) morphinique et se fixe au niveau des récepteurs cérébraux µ et k5. Cette substance a d'abord été produite comme analgésique dans les années 1980. Le médicament est réglementé. Il a secondairement été utilisé pour le traitement substitutif de la dépendance aux opiacés. En France, il est principalement utilisé dans cette indication à haut dosage actuellement.
HHT9JH + + in the urine buprenorphine en metabolite norbuprenorphine, caffeine were identified
HJCDJ2 + + screening and quantitation by GC-MS
J0E7UI + + we found buprenorphine as psychotropic substance and norbuprenorphine as uncontrolled substance
JFDHCS + + The drugs that have been found are synthetic opiates (Buprenophine and Norbuprenophine) that are confirmed by GC/MS analysis thechniques.
JMIFJG + +
JMJLE1 + ANP Buprenorphine was detected in 2020/2/BS-2
JOXEMT + + NORBUPRENORPHINE AND BUPRENORPHINE WERE IDENTIFIED IN THE SAMPLE 2
JW3GXI + + Buprenorphine and norbuprenorphine were detected in 2020/2/BS-2 sample.
KWLGGO + +
LAAAAA + + Il a été détecté la présence de la Buprenorphine et la Norbuprenorphine dans l'échantillon analysé.
LCXPWI + +
LGNUVH + + Buprenorphine and norbuprenorphine are detected in sample number two by EIA, GC/MS, and LC- MS/MS
LHZ8CT + + Positive for buprenorphine and metabolite
LPN77A + + buprenorphine 2887 ng/ml norbuprenorphine 4889 ng/ml
MCZMMA + +
MFPKCL + +
O2A2BN + -
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Code Buprenorphine Norbuprenorphine
O66Z5F + - Buprenorfine
PDDDDD + ANP Buprenorphine detected
PJ6NX9 ANP ANP None
PPQ4MN + ANP
Q33R30 + ANP Buprenorphine was detected in Sample 2020/2/BS-2.
QBVFBW + ANP
QDFCD8 ANP ANP
QMPZYH + +
REBSFB ANP ANP Test sample 2020/2 BS-2 does not contain controlled drugs (Metamfetamine, Amfetamine, 11- nor-∆9-THC-9-carboxylic acid, 3,4-Methylenedioxymetamfetamine (MDMA), Morphine, Codeine, Oxazepam, Nordazepam and Benzoylecgonine), therefore Negative for Screening and Confirmatory analyses.
RMYQAR + + Buprenorphine - Detected Norbuprenorphine - Detected
SW25NX + + Norbup is a metabolite of Bup
T7ZWMT + + we also found traces of caffeine and theobromine
T90OIT + + In sample BS-2 the drugs buprenorphine and norbuprenorphine were detected.
TCP07X + ANP
U4DAAJ - -
UOKKUT ANP -
V4VTFQ + -
VLNX9X + ANP
VUASIY ANP ANP
W8VSHC + ANP
X2CTXX + + 2020/2/BS-2 was containing Buprenorphine and Norbuprenorphine
XEHBYJ + + Sample 2020/2/BS-2 contain buprenorphine, norbuprenorphine
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Code Buprenorphine Norbuprenorphine
Y2QOYO - + Analytical Adverse Finding for norbuprenorphine
YYXEXU + + Norbuprenorphine, Buprenorphine
ZQFW61 + + Buprenorphine and Norbuprenorphine detected
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Identification methods for Test Sample 2
Analytical Technique Codes
Code 100 110 142 150 160 161 170 180 190 230 231 210
0R3CHB I SI
4GKVKL SI SI I
55O3RU SI I
5CHXK3 S SI SI
5ZE565 I SI
666KD9 S I I I
6SJ6SS S I SI
6SOTQX I SI
6UPYUO SI
7BXXXX SI SI
7V7ZMZ S I
8H6FT6 I I SI
8Q9HHM SI SI Immunochromatographic rapid tests
8T20G0 S I I
8V4YGY S I I
90YC0Z S I I
9NNWNO I
9NQ999 S I
9P9B97 I
A65OOQ S I I
AN3H29 I
APEFDF S S SI I
AQAYT9 S I
AXDW2N S I
B3EBPD I I S COBAS
BIDPSO I I
BOCUHG S SI
CAAEEE SI I
DD6DWV SI SI SFC-MS/MS
DEEJ5E SI
DMUL5S S I I
Legend: S ... used for Screening I ... used for Identification SI ... used for both
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Code 100 110 142 150 160 161 170 180 190 230 231 210
DZYOGL S I
E666OG S I SI
EENDPO I
EENW2Z S I
FCUPDY S I
GGCGG3 S I
GRIPEY S I
GTNYPU I
GVGEP9 S I
H8PYU5 S I SI
HCHYZY S I I
HHT9JH SI
HJCDJ2 S I I
J0E7UI S I
JFDHCS I I S Chemical immunoassay techniques
JMIFJG S I
JMJLE1 SI SI
JOXEMT SI
JW3GXI S I I I
KWLGGO S I I
LAAAAA S I SI
LCXPWI I I
LGNUVH S I I
LHZ8CT S I I
LPN77A I SI I
MCZMMA I I S KIMS and LC-Orbitrap MS
MFPKCL S I UHPLC-QTOF
O2A2BN SI LC TOFMS
O66Z5F I SI Dipro Drug Lab screen
PDDDDD I
PJ6NX9 I
PPQ4MN I
Q33R30 SI
QBVFBW S I I
QDFCD8 SI
QMPZYH S I I
REBSFB I S DTK
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Code 100 110 142 150 160 161 170 180 190 230 231 210
RMYQAR S I I
SW25NX S I
T7ZWMT SI I
T90OIT SI SI
TCP07X I
U4DAAJ I I S immunochromatographic test
UOKKUT S I
V4VTFQ SI S Immunochromatographic test
VLNX9X S I SI
VUASIY S I
W8VSHC S I
X2CTXX S I
XEHBYJ S I S Randox Biochip Technology
Y2QOYO SI SI
YYXEXU S I SI
ZQFW61 SI
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12. ANNEX 3: Participants’ results for Test Sample-3 Identified substances for Test Sample 3
Code Identified Substances
0R3CHB Nordazepam
4GKVKL Nordazepam
55O3RU Caffeine, Benzodiazepine drug, Benzenethanamine derivative
5CHXK3 Nordazepam
5ZE565 nordiazepam
666KD9 Nordazepam
6SJ6SS nodiazepam
6UPYUO NONE
7BXXXX Nordiazepam
7V7ZMZ NORDAZEPAM
8H6FT6 Nordiazepam.
8Q9HHM Benzodiazepines
8T20G0 Nordazepam
90YC0Z nordazepam
9NNWNO Nordazepam
9NQ999 Nordazepam
9P9B97 Nordazepam
AN3H29 Nordazepam
APEFDF nordiazepam
AQAYT9 Nordazepam
AXDW2N Nordazepam
B3EBPD buprenorphine
BIDPSO Nordazepam
BOCUHG Nordazepam
CAAEEE NORDAZEPAM
DD6DWV nordazepam
DEEJ5E nordiazepam
DMUL5S Nordazepam
DZYOGL nordazepam
E666OG Benzodiazepines
EENDPO Nordazepam
EENW2Z Nordazepam
GGCGG3 nordazepam
GRIPEY Нордазепам
GVGEP9 nordiazepam
H8PYU5 Nordiazepam
HCHYZY Nordazépam
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Code Identified Substances
HHT9JH nordazepam
HJCDJ2 Nordazepam
J0E7UI Nordazepam
JFDHCS Nordazepam
JMIFJG Nordazepam
JMJLE1 Nordiazepam
JOXEMT NORDAZEPAM
JW3GXI Nordazepam
LAAAAA Nordazepam
LCXPWI Nordazepam
LGNUVH Nordazepam
LHZ8CT MPDV
LPN77A nordazepam
MCZMMA Nordiazepam
MFPKCL Nordazepam
O2A2BN Nordazepam
O66Z5F Benzodiazepines
PDDDDD Nordazepam
PJ6NX9 Nordazepam
PPQ4MN Nordazepam
Q33R30 Nordazepam
QBVFBW Nordazepam
QDFCD8 Nordazepam
REBSFB Nordazepam
RMYQAR Nordiazepam
SW25NX Nordazepam
T7ZWMT nordazepam
T90OIT Nordazepam
TCP07X Nordazepam
U4DAAJ Nordazepam
UOKKUT Nordazepam
VLNX9X nordazepam
VUASIY alprazolam, nordazepam
W8VSHC Nordiazepam
X2CTXX Nordiazepam
XEHBYJ temazepam
Y2QOYO Nordiazepam
YYXEXU Nordazepam
ZQFW61 Nordazepam
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Statement of findings for Test Sample 3
Code Nordazepam
0R3CHB + -
4GKVKL + In the urine sample analyzed was detected and confirmed the presence of nordazepam.
55O3RU - On TLC & GC-MS examination, sample was found to contain Caffeine, Benzodiazepine drug, Benzenethanamine derivative
5CHXK3 + Nordazepam was detected in sample BS-3
5ZE565 + nordiazepam
666KD9 + Specimen 2020/2/BS-3 is positive for drug Nordazepam
6SJ6SS +
6SOTQX ANP
6UPYUO ANP SAMPLE 2020/2/BS-3 FOUND NOT TO CONTAIN ANY DRUGS
7BXXXX + Prior benzodiazepine use (N.B. no other benzos, such as oxazepam detected).
7V7ZMZ +
8H6FT6 + Use of some benzodiazepine type drug or drugs (e.g. chlordiazepoxide, diazepam, medazepam, tetrazepam).
8Q9HHM ANP Presence of Benzodiazepines in the sample 2020/2/BS-3. N.B: The analysis must be confirmed by a chromatographic method to identify and quantify the exact substance.
8T20G0 +
8V4YGY +
90YC0Z + this person consumed one of 1,4-benzodiazepines
9NNWNO +
9NQ999 + In the sample analyzed Nordazepam was found.
9P9B97 + Nordazepam was detected in sample 2020/2/BS-3
A65OOQ +
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Code Nordazepam
AN3H29 + The coincidence between the relative retention time and mass-fragmentograms from a reference standard analyzed at the same conditions that the biological sample, indicates the detection of Nordazepam and caffeine.
APEFDF + Presence of nordiazepam
AQAYT9 + Benzodiazepines was as a positive indicator in screening which then was analyzed quantitatively by LC/MS/MS to show that Nordazepam was present
AXDW2N + Nordazepam was identified by GC/MS analysis
B3EBPD + buprenorphine was found
BIDPSO + Nardazepam is a tranquilliser.
BOCUHG + Positivo to Nordazepam
CAAEEE + CAFFEINE
DD6DWV + positive
DEEJ5E + Subject assuming BDZ (diazepam)
DMUL5S +
DZYOGL + A solid phase extraction for benzodiazepines was performed and confirmed by a specific analysis method in GC/MS
E666OG + Nordazepam
EENDPO + Nordazepam was detected in BS-3 Sample.
EENW2Z + Nordazepam in concentration of 518.2+-8.8 ng/mL
FCUPDY +
GGCGG3 + recent intake of nordazepam. Possible presence in urine as metabolite of other benzodiazepines, although in absence of the parent compound.No information on the conditions of the subject at the time of sample collection.
GRIPEY +
GTNYPU ANP
GVGEP9 +
H8PYU5 + It indicates the past intake of diazepam or the intake of nordiazepam.
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Code Nordazepam
HCHYZY + Nordazepam est un dérivé de 1,4 benzodiazépine avec des propriétés amnésiantes, anticonvulsivantes, anxiolytique, relaxant musculaire et sédatives. Il s’agit d’un métabolite actif du diazépam, chlordiazépoxide, prazepam etc. utilisé principalement dans le traitement des troubles anxieux. Les effets secondaires courants du nordazepam incluent la somnolence et l'amnésie
HHT9JH + in the urine nordazepam and caffeine were identified
HJCDJ2 + screening with rapid test kit and quantitation by GC-MS
J0E7UI + we found Nordazepam as psychotropic substance
JFDHCS + The drug that has been found is Nordazepam. It belongs to the class of benzodiazepines.
JMIFJG +
JMJLE1 + 2020/2/BS-3 contains 393 ng/mL nordiazepam
JOXEMT + NORDAZEPAM WAS IDENTIFIED IN THE SAMPLE 3
JW3GXI + Nordazepam was detected in 2020/2/BS-3 sample.
KWLGGO +
LAAAAA + projection par confirmée par la technique HPLC
LCXPWI +
LGNUVH + Benzodiazepine is detected in sample number three by EIA, and confirmed by GC/MS, and LC- MS/MS as Nordazepam
LHZ8CT ANP Negative (MPDV under cut-off)
LPN77A + nordazepam 565 ng/ml
MCZMMA +
MFPKCL +
O2A2BN +
O66Z5F - Temazepam
PDDDDD + Nordazepam detected
PJ6NX9 + Nordazepam is a derivative of 1, 4-benzodiazepines and is prescribed in the First and Third Schedules (Psychotropic Substances), Poisons Act 1952.
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Code Nordazepam
PPQ4MN +
Q33R30 + Nordazepam was detected in Sample 2020/2/BS-3.
QBVFBW +
QDFCD8 +
QMPZYH +
REBSFB + Test sample 2020/2/BS-3 was found to contain controlled drugs for Nordazepam, therefore Positive for the Screening and Confirmatory analyses with concentration value of 329.87 ng/mL.
RMYQAR + Nordiazepam ~0.4mg/L
SW25NX + Nordazepam is a benzodiazepine
T7ZWMT + we also found traces of caffeine and theobromine
T90OIT + In sample BS-3 the metabolite nordazepam was detected.
TCP07X +
U4DAAJ +
UOKKUT +
V4VTFQ +
VLNX9X +
VUASIY +
W8VSHC +
X2CTXX + 2020/2/BS-3 was containing Nordiazepam
XEHBYJ - Sample 2020/2/BS-3 contain temazepam
Y2QOYO + Analytical Adverse Finding for nordiazepam
YYXEXU + Nordazepam
ZQFW61 + Nordazepam detected
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Identification methods for Test Sample 3
Analytical Technique Codes
Code 100 110 142 150 160 161 170 180 190 230 231 210
0R3CHB I SI
4GKVKL SI SI I
55O3RU SI I
5CHXK3 S SI SI
5ZE565 I SI
666KD9 S I I I
6SJ6SS S I SI
6SOTQX I SI
6UPYUO SI
7BXXXX SI SI
7V7ZMZ S I
8H6FT6 I I SI
8Q9HHM SI SI Immunochromatographic rapid tests
8T20G0 S I I
8V4YGY S I I
90YC0Z S I I
9NNWNO I
9NQ999 S I
9P9B97 I
A65OOQ S I I
AN3H29 I
APEFDF S S SI I
AQAYT9 S I
AXDW2N S I
B3EBPD I I S COBAS
BIDPSO I I
BOCUHG S SI
CAAEEE SI I
DD6DWV SI SI SFC-MS/MS
DEEJ5E SI
DMUL5S S I I
Legend: S ... used for Screening I ... used for Identification SI ... used for both
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Code 100 110 142 150 160 161 170 180 190 230 231 210
DZYOGL S I
E666OG S I SI
EENDPO I
EENW2Z S I
FCUPDY S I
GGCGG3 S I
GRIPEY S I
GTNYPU I
GVGEP9 S I
H8PYU5 S I SI
HCHYZY S I I
HHT9JH SI
HJCDJ2 S I I
J0E7UI S I
JFDHCS I I S Chemical immunoassay techniques
JMIFJG S I
JMJLE1 SI SI
JOXEMT SI
JW3GXI S I I I
KWLGGO S I I
LAAAAA S I SI
LCXPWI I I
LGNUVH S I I
LHZ8CT S I I
LPN77A I SI I
MCZMMA I I S KIMS and LC-Orbitrap MS
MFPKCL S I UHPLC-QTOF
O2A2BN SI LC TOFMS
O66Z5F I SI Dipro Drug Lab screen
PDDDDD I
PJ6NX9 I
PPQ4MN I
Q33R30 SI
QBVFBW S I I
QDFCD8 SI
QMPZYH S I I
REBSFB I S DTK
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ICE 2020/2-BS
Code 100 110 142 150 160 161 170 180 190 230 231 210
RMYQAR S I I
SW25NX S I
T7ZWMT SI I
T90OIT SI SI
TCP07X I
U4DAAJ I I S immunochromatographic test
UOKKUT S I
V4VTFQ SI S Immunochromatographic test
VLNX9X S I SI
VUASIY S I
W8VSHC S I
X2CTXX S I
XEHBYJ S I S Randox Biochip Technology
Y2QOYO SI SI
YYXEXU S I SI
ZQFW61 SI
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13. ANNEX 4: Participants’ results for Test Sample-4 Identified substances for Test Sample 4
Code Identified Substances
0R3CHB 3,4-Methylenedioxymetamfetamine (MDMA)
4GKVKL MDMA
55O3RU Caffeine and Opiates
5CHXK3 3,4-Methylenedioxymetamfetamine (MDMA)
5ZE565 amphetamines
666KD9 MDMA
6SJ6SS MDMA
6SOTQX MDMA
6UPYUO 3,4-Methylenedioxymetamfetamine (MDMA)
7BXXXX MDMA
7V7ZMZ MDMA
8H6FT6 MDMA
8Q9HHM 3,4-Methylenedioxymetamfetamine (MDMA)
8T20G0 MDMA
90YC0Z MDMA
9NNWNO MDMA
9NQ999 MDMA
9P9B97 MDMA
APEFDF MDMA
AQAYT9 MDMA
AXDW2N 3,4-Methylenedioxymetamfetamine (MDMA)
B3EBPD 3,4-Methylenedioxy-metamfetamine
BIDPSO 3,4-methelynedioxy-metamfetamine(MDMA)
BOCUHG 3,4-Methylenedioxymetamfetamine (MDMA)
CAAEEE MDMA
DD6DWV MDMA
DEEJ5E MDMA
DMUL5S MDMA
DZYOGL Anfetamine
E666OG MDMA
EENDPO MDMA
GGCGG3 MDMA
GRIPEY Метамфетамин
GTNYPU THC, MDMA
GVGEP9 morphin
H8PYU5 MDMA
HCHYZY MDMA
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Code Identified Substances
HHT9JH MDMA
HJCDJ2 3,4-Methylenedioxymetamfetamine (MDMA)
J0E7UI 3,4-methylenedioxymethamphetamine
JFDHCS 3,4- Methylenedioxy-methamfetamine(MDMA)
JMIFJG 3,4-Methylenedioxymetamfetamine (MDMA)
JMJLE1 Methylenedioxymethamphetamine
JOXEMT MDMA
JW3GXI MDMA
LAAAAA MDMA
LCXPWI 3,4-Methylendioxymetamfetamine (MDMA)
LGNUVH MDMA
LHZ8CT MDMA
LPN77A MDMA
MCZMMA MDMA
MFPKCL 3,4-Methylenedioxymetamfetamine (MDMA)
O2A2BN Mephedrone
O66Z5F Amfetamine grups
PDDDDD MDMA
PJ6NX9 3,4-Methylenedioxymetamfetamine (MDMA)
PPQ4MN MDMA
Q33R30 3,4-Methylenedioxymetamfetamine (MDMA)
QBVFBW MDMA (N-Methyl-3,4-methylenedioxyamphetamine)
QDFCD8 MDMA
REBSFB 3,4-Methylenedioxymetamfetamine (MDMA)
RMYQAR MDMA
SW25NX MDMA
T7ZWMT MDMA
T90OIT 3,4- Methylenedioxymetamfetamine (MDMA)
TCP07X 3,4-Methylenedioxymetamfetamine (MDMA)
U4DAAJ 3,4-Methylenedioxymetamfetamine (MDMA)
UOKKUT 3,4-Methylenedioxymetamfetamine (MDMA)
VLNX9X MDMA
VUASIY MDMA
W8VSHC MDMA
X2CTXX MDMA
XEHBYJ MDMA
Y2QOYO MDMA
YYXEXU 3,4-Methylenedioxymetamfetamine (MDMA)
ZQFW61 MDMA
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Statement of findings for Test Sample 4
Code 3,4-Methylenedioxymetamfetamine (MDMA)
0R3CHB + -
4GKVKL + In the urine sample analyzed was detected and confirmed the presence of MDMA.
55O3RU - On TLC & GC-MS examination, sample was found to contain Caffeine and Opiates
5CHXK3 + 3,4-Methylenedioxymetamfetamine (MDMA) was detected in sample BS-4
5ZE565 + MDMA
666KD9 + Specimen 2020/2/BS-4 is positive for drug MDMA
6SJ6SS +
6SOTQX + Consistent with the use of MDMA
6UPYUO + SAMPLE 2020/2/BS-4 FOUND TO CONTAIN 3,4-Methylenedioxymetamfetamine (MDMA)
7BXXXX + Prior MDMA use
7V7ZMZ +
8H6FT6 + Use of Extasy.
8Q9HHM + Presence of 3,4-Methylenedioxymetamfetamine (MDMA) in the sample 2020/2/BS-4. N.B: The analysis must be confirmed by a chromatographic method to identify and quantify the found substance.
8T20G0 +
8V4YGY +
90YC0Z + this person consumed MDMA
9NNWNO +
9NQ999 + In the sample analyzed MDMA was found.
9P9B97 + MDMA was detected in sample 2020/2/BS-4
A65OOQ +
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Code 3,4-Methylenedioxymetamfetamine (MDMA)
AN3H29 -
APEFDF + Presence of MDMA
AQAYT9 + Amphetamine group was determined as a positive indicator in screening analysis which was then confirmed quantitively that the sample contained MDMA
AXDW2N + 3,4-Methylenedioxymetamfetamine (MDMA) was identified by GC/MS analysis
B3EBPD + MDMA was found
BIDPSO + 3,4-methylenedioxymetamfetamine is a stimulant and a hallucinogen.
BOCUHG + Positive to 3,4-Methylenedioxymetamfetamine (MDMA)
CAAEEE + QUETIAPINE, CAFFEINE
DD6DWV + positive
DEEJ5E + MDMA user
DMUL5S +
DZYOGL - A solid phase extraction for anfetamines was performed and confirmed by a specific analysis method in GC/MS
E666OG + MDMA
EENDPO + MDMA was detected in BS-4 Sample.
EENW2Z - None of the substances refered to in the list
FCUPDY ANP
GGCGG3 + recent intake of MDMA, noticeable the absence of MDA, its metabolite. No information on the conditions of the subject at the time of sample collection.
GRIPEY -
GTNYPU +
GVGEP9 -
H8PYU5 + It indicates the intake of MDMA.
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Code 3,4-Methylenedioxymetamfetamine (MDMA)
HCHYZY + La MDMA, aussi appelée ecstasy, est une drogue illicite que l’on trouve en France principalement sous forme de pilules. C’est un entactogène amphétamines utilisées dans les fêtes.
HHT9JH + in the urine MDMA and caffeine were identified
HJCDJ2 + screening with rapid test kit and quantitation by LC-MS
J0E7UI + we found 3,4-methylenedioxymethamphetamine as narcotic substance
JFDHCS + The drug that has been found is 3,4- Methylenedioxy-methamfetamine(MDMA). It belongs to the class of AMPHETAMINE.
JMIFJG +
JMJLE1 + Methylenedioxmethamphetamine was detected in 2020/2/BS-4
JOXEMT + MDMA WAS IDENTIFIED IN THE SAMPLE 4
JW3GXI + MDMA was detected in 2020/2/BS-4 sample.
KWLGGO +
LAAAAA + la présence de la MDMA dans BS4 a été identifiée par 161 technic
LCXPWI +
LGNUVH + Amphetamine-type stimulant drug is detected in sample number four, by both GC/MS and EIA, and confirmed as MDMA by LC-MS/MS
LHZ8CT + Positive for MDMA
LPN77A + MDMA 1373 ng/ml
MCZMMA +
MFPKCL +
O2A2BN -
O66Z5F + 3,4-Methylenedioxymetamfetamine (MDMA)
PDDDDD + 3,4-Methylenedioxymetamfetamine detected
PJ6NX9 + 3,4-Methylenedioxymetamfetamine (MDMA) is as listed in the First Schedule of Dangerous Drugs Act 1952.
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Code 3,4-Methylenedioxymetamfetamine (MDMA)
PPQ4MN +
Q33R30 + 3,4-Methylenedioxymetamfetamine (MDMA) was detected in Sample 2020/2/BS-4.
QBVFBW +
QDFCD8 +
QMPZYH +
REBSFB + Test sample 2020/2/BS-4 was found to contain controlled drugs for 3,4- Methylenedioxymetamfetamine (MDMA), therefore Positive for the Screening and Confirmatory analyses with concentration value of 765.78 ng/mL.
RMYQAR + MDMA Detected > 0.5mg/L
SW25NX + MDMA is a derivative of Amphetamine
T7ZWMT + we also found traces of caffeine and theobromine
T90OIT + In sample BS-4 the drug 3,4- methylenedioxymetamfetamine (MDMA) was detected.
TCP07X +
U4DAAJ +
UOKKUT +
V4VTFQ +
VLNX9X +
VUASIY +
W8VSHC +
X2CTXX + 2020/2/BS-4 was containing MDMA
XEHBYJ + Sample 2020/2/BS-4 contain MDMA
Y2QOYO + Analytical Adverse Finding for MDMA
YYXEXU + 3,4-Methylenedioxymetamfetamine (MDMA)
ZQFW61 + MDMA detected
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Identification methods for Test Sample 4
Analytical Technique Codes
Code 100 110 142 150 160 161 170 180 190 230 231 210
0R3CHB I SI
4GKVKL SI SI I
55O3RU SI I
5CHXK3 S SI SI
5ZE565 I SI
666KD9 S I I I
6SJ6SS S I SI
6SOTQX I SI
6UPYUO SI
7BXXXX SI SI
7V7ZMZ S I
8H6FT6 I I SI
8Q9HHM SI SI Immunochromatographic rapid tests
8T20G0 S I I
8V4YGY S I I
90YC0Z S I I
9NNWNO I
9NQ999 S I
9P9B97 I
A65OOQ S I I
AN3H29 I
APEFDF S S SI I
AQAYT9 S I
AXDW2N S I
B3EBPD I I S COBAS
BIDPSO I I
BOCUHG S SI
CAAEEE SI I
DD6DWV SI SI SFC-MS/MS
DEEJ5E SI
DMUL5S S I I
Legend: S ... used for Screening I ... used for Identification SI ... used for both
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Code 100 110 142 150 160 161 170 180 190 230 231 210
DZYOGL S I
E666OG S I SI
EENDPO I
EENW2Z S I
FCUPDY S I
GGCGG3 S I
GRIPEY S I
GTNYPU I
GVGEP9 S I
H8PYU5 S I SI
HCHYZY S I I
HHT9JH SI
HJCDJ2 S I I
J0E7UI S I
JFDHCS I I S Chemical immunoassay techniques
JMIFJG S I
JMJLE1 SI SI
JOXEMT SI
JW3GXI S I I I
KWLGGO S I I
LAAAAA S I SI
LCXPWI I I
LGNUVH S I I
LHZ8CT S I I
LPN77A I SI I
MCZMMA I I S KIMS and LC-Orbitrap MS
MFPKCL S I UHPLC-QTOF
O2A2BN SI LC TOFMS
O66Z5F I SI Dipro Drug Lab screen
PDDDDD I
PJ6NX9 I
PPQ4MN I
Q33R30 SI
QBVFBW S I I
QDFCD8 SI
QMPZYH S I I
REBSFB I S DTK
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Code 100 110 142 150 160 161 170 180 190 230 231 210
RMYQAR S I I
SW25NX S I
T7ZWMT SI I
T90OIT SI SI
TCP07X I
U4DAAJ I I S immunochromatographic test
UOKKUT S I
V4VTFQ SI S Immunochromatographic test
VLNX9X S I SI
VUASIY S I
W8VSHC S I
X2CTXX S I
XEHBYJ S I S Randox Biochip Technology
Y2QOYO SI SI
YYXEXU S I SI
ZQFW61 SI
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