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International/Global, Center for AIDS Research, & Public Health Collaborations
Sten H. Vermund, MD, PhDYale School of Public [email protected]
30 April 2019
Acknowledgment of Funding
• HIV Prevention Trials Network (S. Vermund, PI of Yale subcontract from FHI 360)
– NIH: UM1 AI068619
• Center for Interdisciplinary Research on AIDS (P. Cleary, PI)
– NIH: P30 MH062294
• Yale Cancer Center (C. Fuchs, PI)
– NIH: P30 CA006516
• New methods for design and evaluation of large HIV prevention interventions (D. Spiegelman, PI)– NIH: R01 AI112339
I. INTERNATIONAL RESEARCH
• Did you know that Yale has substantial NIH-funded research &/or training grants in these LMICs?
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CHINA
INDIA
MALAYSIA
NEPAL
KENYA
ETHIOPIA
UGANDA
GHANA
SENEGAL
LIBERIA
MOZAMBIQUE
SO AFRICA
ZAMBIA
BRAZIL
PERU
E.CARIBBEAN
MEXICO
UKRAINE
Nearly all global Yale CA grants are lab-based - I
Grants in –omics/basic science and infrastructureA new role for the PAX9 protein in ribosome biogenesis R01GM BASERGA SJGenomics; Genetics and Epigenetics Research Program P30CA BOSENBERG MWHigh-throughput in vivo genetics for immunotherapy target discovery DP2CA CHEN SYale Cancer Center NCTN LAPS UG1CA FUCHS CSMolecular mechanisms of the maternal to zygotic transition R35GM GIRALDEZ AJRole of clonal expansion in HIV-1 persistence R01AI HO YCCore C: RNA Sequencing Core P01AI LOVE JCElucidating KRAS-specific vulnerabilities in pancreatic cancer K08CA MUZUMDAR MD
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Grants in Therapy, more lab orientedYale SPORE in Lung Cancer (YSILC): The biology and personalized treatment of lung cancer P50CA HERBST RSMechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitors R01CA HEROLD KC Investigating targeted degradation of c-Met to realize more effective cancer treatment R50CA HINES JFMechanical self-assembly of dense fibrotic tumor microenvironment: Mechanisms, therapy R21EB MAK M The role of ALDH1B1 in ethanol metabolism and colon cancer R01AA VASILIOU VNucleoporin NUP205-driven novel pathway in melanoma tumor growth and metastasis R01CA WAJAPEYEE N
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Nearly all global Yale CA grants are lab-based-II
Grants in Therapy, more clinically orientedPersonalized Therapy for p16-Deficient Melanoma R03CA GUPTA RImmune biological differences: Triple Negative Breast CC in African American & non-AA women (immunotherapy) R01CA PUSZTAI LUsing the RE-AIM model to translate distress screening into cancer care R25CA MCCORKLE RA novel druggable genetic vulnerability pathway In melanoma R01CA WAJAPEYEE NExplore piRNA as a novel therapeutics for hepatocellular carcinoma R21CA ZHU Y
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Nearly all global Yale CA grants are lab-based-III
Neurosciences with CA relevance; Other CA-related topicsGABAergic contributions to neural circuit deficits in schizophrenia R01MH CARDIN JAObesity-driven endometrial hyperplasia in postmenopausal women: (insulin & estrone) R01HD FLANNERY CAMolecular mechanisms & social constructs: How genes & environment regulate rate of aging R00AG LEVINE ME2/2 Somatic mosaicism and autism spectrum disorder U01MH SESTAN N Effects of hepatic Acetyl-CoA Carboxylase inhibition on NAFLD and hepatic insulin resistance R01DK SHULMAN GIFood cues; stress; motivation for highly palatable foods and weight gain R01DK SINHA R
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Nearly all global Yale CA grants are lab-based-IV
YCC HAS IMMENSE GROWTH POTENTIAL
• Etiological studies: Compare and contrast
putative genetic, infectious, environmental, lifestyle causes of selected cancers in diverse ecological venues, e.g., higher vs lower income, tropical vs temperate climates, co-infection environments
• Clinical studies
– Lower toxicity, lower cost chemotherapy regimens suitable for resource-limited settings
– Protocols of dual US/LMIC relevance, e.g., China
• Outcomes research/Implementation sci.
– Health systems research; workforce capacity
– Integration with existing Yale overseas projects
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II. EXAMPLE: Centers for AIDS Research
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19 CFARs funded by
NIH, with >34
participating
institutions & 12
major consortia,
including the
Inter-CFAR HIV/AIDS
Related Malignancy
(iCHARM) Working
Group
Yale U - UPR Developmental CFAR
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To date, not
participating is
the state of
Connecticut
and the
Commonwealth
of Puerto Rico
A natural link: Puerto Ricans
are a higher proportion of the
population of CT (7.1%) than
any other U.S. state.
Lacking a CFAR: a missing opportunity
• HIV/AIDS & Aging Chronic inflammation
– AIDS-related cancers
– Non-AIDS-related cancers
• Neurosciences/Cancer interface
– HIV is neurotropic and immunotropic
– Very strong Yale basic & clinical neurosciences
• Implementation science
– Better health outcomes through prophylaxis, screening, and access to care
– Reducing health disparities in both cancer and HIV outcomes
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III. YSPH Collaborations
• Brain tumor: diagnoses with novel MRI strategies
• Breast cancers: molecular expression
• Cervical cancer: control in LMICs
• Environmental/toxic exposures: synthetic rubber
• Esophageal squamous cell CA: molecular markers
• Exercise and cancer outcomes
• Gastric cancer risk
• Molecular epidemiology of key cancers
• Pancreatic cancer: H. pylori inflammation
• Pediatric cancers: risks, frequencies, etiologies
• And others!
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176 YSPH global CA articles, past 5 yrs
• Lu Lingeng (CDE): BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer. BMC Cancer 2019
• Yong Zhu (EHS): …CA stem cell molecular markers & effects of hsa-miR-21-3p on stemness in esophageal squamous cell carcinoma. Cancers 2019
• Baosen Zhou (EHS): Population susceptibility differences & effects of air pollution on CV mortality:… time-series study. Environ Sci Pollut Res Int 2019
• Yuqing Shang (CDE): MRI texture analysis based on 3D tumor measurement reflects the IDH1 mutations in gliomas. Eur J Radiol 2019;
• 2nd article: Meningioma grading using conventional MRI histogram analysis based on 3D tumor measurement.
More 2019 articles
• Raúl U. Hernández‐Ramírez (BIOST): Education and
gastric CA risk-An individual participant data meta-analysis…StoP project consortium. Int J Cancer 2019
• 2nd article: Citrus fruit intake and gastric CA: The stomach cancer pooling (StoP) project consortium.
• Yawei Zhang (EHS/Surgery): Predictors of 30 day readmission following percutaneous cholecystostomy. J Surg Res 2019
• Nicole Deziel, Caroline Johnson, Vasilis Vasiliou (EHS): Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber. Environ Res 2019
• Lu Lingeng (CDE): Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer. Clin Transl Oncol 2019
Take home messages
• YCC can leverage its basic science cancer portfolio and the clinical research excellence in the Smilow Cancer Hospital to engage key clinical oncology, outcomes research, and implementation science questions globally.
• We are making a serious move to get a CFAR to Yale. If you are interested, get in touch with me ([email protected]). Look for our internal RFA in May for small grants.
• The YSPH, as well as the YSM and YSN, have considerable global connectedness that can be exploited for cancer research partnerships.
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We can help you connect globally
• YIGH
– Saad Omer (July) and Mike Skonieczny (now)
• YSPH/CDE
– Melinda Irwin and Xiaomei Ma
• YSPH/EHS
– Yawei Zhang and Yong Zhu
• Developmental CFAR
– Amy Justice and Sten Vermund
• Many others in our wide YCC, YIGH, and other Yale global networks
Thank you! [email protected]
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