Interventional MRIMagnetoencephalography

Verification of Functional Imaging with Interventional MRI: Mapping of Epilepsy and Eloquent Cortex

Steven Stufflebeam, M.D. (MGH)Ronald Kikinis, M.D. (BWH)

Partners Radiology Research Award

Interictal Spike Localization

MEG

Greg Sorensen

Structural Connectivity: DTI Tractography

Functional Connectivity:BOLD fMRI

Vincent & Buckner, 2006

Effective Connectivity:MEG dynamic SEM

Fa-Hsuan Lin

Brain Connectivity

Combining Advanced Imaging Technologies: Sum is greater than the Parts

Tumor, MEG, MRAngo, DTI fMRI

Stephen Piper, Ph.D.

DTI

T2 MRI Tumor

Isopoential Field Maps (MEG)

MEG Dipole For Language Stimuli

Language Mapping in Temporal Lobe Tumor

CDr. Alexandra Golby Dr. Ralph SuarezDr. Ronald Kikinis.Dr. Stufflebeam

Dr. Alex Golby Dr. Ralph Suarez.Dr. Stufflebeam

Why is this research important?

• Translational research: bench to bedside.• Multidisciplinary and cross-institutional: Physics, software

engineering, mathematics, neurosurgery, neurology.• Leverages the resources of the BWH & MGH to advance

researchdirectly to patients/physicians.– 250 epilepsy & brain tumor patients from MGH/BWH

– Awards at ISCAMEG, HBM, ISB

– HST.583 Imaging Biophysics & Clin Apps

– Grants R01, P41, K08, K25, CIMIT

Thanks

BWH

• Ron Kikikis

• Stephen Piper

• Ferenc Jolesz

• Ralph Suarez

• Alexandra Golby

• Joseph Madsen

• Ed Bromfield

• Barabara Dworetzky

• Jong Lee

MGH/Martinos Center• Emad Eskandar• Reese Cosgrove• Andy Cole• Ronan Kilbride• Matti Hamalainen• Fa-Hsuan Lin• Greg Sorensen• Randy Buckner• Gordon Harris• Giorgio Bonmassar