Introducing: SPEARTM Biopesticide Products

ABIM

October 20th, 2015

Basel, Switzerland

SPEAR™ Active Ingredient:GS-omega/kappa-Hxtx-Hv1a

Omega/Kappa - K+ & Ca++ CNS channel antagonist

GSQYCVPVDQPCSLNTQPCCDDATCTQERNENGHTVYYCRAH2N OH

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• Two modes of action – built in resistance management

– Voltage activated Calcium ion channel inhibitor

– Potassium ion channel inhibitor

• Two routes of entry– Contact – for existing insects at the

time of spray (through spiracles/surface to volume ratio)

– Oral ingestion – for insects that appear post-spray (synergistically enhanced by Bt)

Modes of Action/Exposure

Characteristics of the Biopesticide

• Broad pest killing spectrum

• Two novel modes of action

• Water soluble

• Resistant to extremes of pH, sunlight, temperature

• Non-toxic to mammals & birds, fish– Submitted pollinator & have beneficial data

• 0 Days Pre-harvest Interval

• 4 hr Re-entry Interval

• No toxic residues

• Effective for 7 – 10 days in the field

• EPA and California approved

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Initial Market Entry Point – SPEAR™-T

• Market launch in late 2015/early 2016

• Controls thrips and whiteflies in greenhouses

• Field trials (14,000 sq ft) have demonstrated that results are equivalent or superior to conventional control chemicals

Spear™-T will be priced comparably to conventional control chemicals

Greenhouse Grower Trials

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Days After Treatment

Kalamazoo Glasshouse Trial North Range VST 6330 and Overture + Enstar AQ vs. Western Flower Thrips

1st Spray Application September 2014

VST 6330

Overture + Enstar

Chitin inhib. + pyrethrin

Greenhouse Grower Trials

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Days After Treatment

Kalamazoo Glasshouse North Range VST6330 and Pedastel + Avid vs. Western Flower Thrips

2nd Spray Application September 2014

VST6330

Pedestal + Avid

IGR + Avermectin

Control of Thrips in Greenhouses

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Days After Treatment

Kalamazoo Glasshouse Trial South RangeVST 6330 and Pylon vs. Western Flower Thrips

1st spray application September 2014

SPEAR™-T

Pylon - BASF

Treatment Area 14, 000 square feet

chlorphenapyr

Onion Thrips Trials

Confidential - Do Not Duplicate

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Ranked Efficacy ResultsU of Wisconsin - Onion thrips

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Movento

Agri-mek

VST EP

Warrior II

Radiant

Exirel

Aug 18 (7 DAT)

• First outdoor trial against thrips

• Modest control but mid-pack with commercial synthetic standards

• Complementary control for potatoes

Tetramic acidAvermectinSPEAR™PyrethroidSpinetroramRyanodine

Innovation: Using Bt to Bite

• Mixing omega/kappa with Btyields a synergistic response –due to Bt’s effects on the gut

• The combination product:

– Longer duration than Bt alone

– Kills larger instars of insects than Btalone

– Kills more extensively than Bt alone

Early market prep will be with tank mix but full launch will be a co-formulation

Synergy With Bt

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24, 48 hr Mortality2nd Instar Beet Army Worm

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UTC SPEAR™ Bt Combination

24,48 hr Mortality2nd Instar Colorado Potato Beetle

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UTC SPEAR™ Bt Combination

24 hr MortalityMosqito Larvae

A difficult lab experiment!

Sub-lethal doses of Peptide and Bt, and the combination of the two at the same concentrations

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48 hr

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Combination product in the field

Mortality

Bt Levels Decreasing

Peptide Levels Decreasing

Peptide + Bt

7-10 days

Bt

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This is a reconstructed thought experiment, not an indictment.

2nd Instar H. zea on Tomatoes

UTC 1lb Btk 1lb Btk+0.2lb SPEAR™

1lb Btk+0.4lb SPEAR™

1 DAT3 DAT7 DAT10 DAT

Arizona Grower Trial - 2015

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Marketable Celery Heads

UTC Spear-C Coragen Radiant Proclaim

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Three consecutive sprays with Spear-C or industry standards at label rates followed by harvest and evaluation of marketable heads.

Ryanodine Spinetoram Avermectin

Peach Twig Borer in Almonds

Confidential - Do Not Duplicate

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Hull Damage Scores

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UTC Altacor3.5 oz

Intrepid12 0z

VST06330 + Javelin0.125 lb

VST06330 + Javelin0.250 lb

VST06330 + Javelin0.500 lb

Ryanodine IGR Bt

Colorado Potato Beetle – WI, USA

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8/11/2015 3 DAT 8/18/2015 1 DAT

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Assesment Dates and DAT Timing

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Btt + VST 0.1 lb

Rimon

Btt + VST 0.4 lb

Exirel

Besiege

Blackhawk

Belay

Agri Mekaa

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SPEAR™-PChitin Synthesis InhibSPEAR™-PRyanodineRyanodine + PyrethrinSpinosadNeonicAvermectin

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Colorado Potato Beetle - NY

Confidential - Do Not Duplicate

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Pre treat 2-Jul 8-Jul

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Assesment Dates

Novodor SC + VST 006330 EP CPB Efficacy vs Leverage 2.7

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Btt +VST 1.6 oz/a

Btt +VST 6.4 oz/a

Leverage 3 oz/a

Imidacloprid

Colorado Potato Beetle - Canada

Confidential - Do Not Duplicate

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Ontario Canada CPB Trials

1 DAT

2nd spray 3 DAT

7 DAT

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UTC0.1 Lbs + Novodor

0.4 Lbs +Novodor

CoragenRyanodine

Cabbage Trial- Cabbage Looper

Confidential - Do Not Duplicate

UTC

.125 lb Spear + 1lb DiPel

Coragen 5fl oz

.250 lb Spear + 1lb DiPel

.500 lb Spear + 1lb DiPel

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Cabbage Trial – Sanger, CA

Ryanodine

Product Comparison

Bt Alone SPEAR™ SPEAR™ + Bt

Spectrum Leps, Coleop & Diptera

Thrips, Whiteflies

Leps, Coleop & Diptera

%Control 70-80% >95% >95%

Instars 1st All Up to 3rd

Exposure Oral Contact Oral & Contact

Duration 1-3 days 7 days 7-10 days

Resistance Emerging None None

Application Spray Fogging Low to ULV spray

Re-entry 4hrs 4hrs 4hrs

Pre-harvest Int. 0 day 0 day 0 day

OMRI Some No No

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First A.I. – Multiple SPEAR™ Products

SPEAR™ - Three Biopesticide Sprays

– SPEAR-T™ – greenhouse thrips and whiteflies

– SPEAR-P™ – w/ Btt - Colorado potato beetle

– SPEAR-C™ – w/ Btk - Broad Lepidopteran control

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Transforming the R&D Model for InsecticidesMOA by MOA

•Single technology platform for multiple MOAs•Peptides for Na+, Cl-, Neonic, Ca++, etc

•Safety at first stage gate – No late stage product attrition•Proven modes of action with restart on resistance clock•Manufacturing, formulation and regulatory path largely solved

Why would anyone spend $300M and wait 10 years for a synthetic, when you could spend $10M over 5 years for an

equivalently effective and yet safer product platform?

VESTARON CORPORATION’sSPEAR™

Transforming Insecticide DevelopmentMOA by MOA

Robert M. Kennedy, PhDChief Scientific Officer

269-544-3007

www.vestaron.com

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Extras