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European Life Sciences Infrastructure for Biological Information www.elixireurope.org Introduction to ELIXIR Andy Smith, ELIXIR Hub 18 March 2015 ‐ Wageningen

Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

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Page 1: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

European Life Sciences Infrastructure for Biological Informationwww.elixir‐europe.org

Introduction to ELIXIR

Andy Smith, ELIXIR Hub 18 March 2015 ‐Wageningen

Page 2: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

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medicine

agriculture

bioindustries

environment

ELIXIR connects national bioinformatics centres and EMBL‐EBI into a sustainable  European infrastructure for biological research data

ELIXIR underpins life science research – across academia and industry

www.elixir-europe.org

Page 3: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

N Databases

Gig

abyt

esThe data challenge: Volume 

Page 4: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

The data challenge: Geographically disperse 

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• Data production sites increasing across Europe

• European Illuminasales up 20% 2o14

Source: http://omicsmaps.com

Page 5: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

databasesdatabases

Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2012. MY Galperin, GR Cochrane – Nucleic Acids Research, 2011

The data challenge: diversity

• Diverse• Plentiful• Disperse

Page 6: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

An international distributed infrastructure for

• Data

• Standards

• Tools

• Compute

• Training

• Industry

Page 7: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

A distributed infrastructure scales with the challenges 

• ELIXIR deliver services through national ELIXIR Nodes

• ELIXIR Nodes build local bioinformatics capacity throughout Europe

• ELIXIR Nodes build on national strengths and priorities

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Page 8: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR funding

Hub funded  jointly by 

ELIXIR member states

Joint applications 

to EU funding

Nodes funded by national agencies

Page 9: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR Nodes        

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• Over 100 institutes involved in ELIXIR Nodes

• Collaboration Agreements to be signed between Hub and Nodes

• Nodes that are national networks are developing own internal Node agreements 

Page 10: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR Core Data Resources

• Small subset of ELIXIR data resources and archives

• Fundamental importance to life science 

• Long term preservation and reuse of biological data

Focal point of ELIXIR’s technical and science policy actions for data sustainability

Page 11: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR Named Services

• Quality indicator of the Service or Tool • have clearly outlined terms of usage, 

• declared service levels and monitoring

• vetted by the ELIXIR SAB as part of Node application

• Sustainability & Commitment to Service• Described in Service Delivery Plans annexed to the Hub‐

Node Collaboration Agreements

Page 12: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR tools and data registry 

Page 13: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

Integration and interoperability of resources

• Formats, Ontologies, Guidelines, …

• Professional skills for managing and exploiting data

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“… typically 40% of our effort in biomarker discovery is data integration”J. Wojcik, CEO, Quartz Bio

Page 14: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

Data interoperability – Human Protein Atlas

The Human Protein Atlas portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in 46 different normal human tissues and 20 different cancer types, as well as 47 different human cell lines.

Page 15: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR pilots to address key challenges in biomedical research:

1. Cloud computing“Embassy cloud”: Access reference data in a virtual environment – work as though you are at EMBL-EBI or SIB, Switzerland

3. High-Performance Computing“Lightpath”: Connections for on-demand reference data to remote HPC centres at EMBL-EBI and CSC Finland

2. Authentication & AuthorisationImproved methods and processes for access to clinical data

Page 16: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR prioritised by ESFRI and Council of EU

Page 17: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR‐EXCELERATE 

• ELIXIR’s application following ESFRI Prioritisation in 2014

• Results expected in Spring; project start Summer

• Eur 19 million 4 year project

• Focus on accelerating the implementation of ELIXIR 

• Use case on Plant Sciences: Integrating Genomic and Phenotypic Data for Crop and Forest Plants 

Page 18: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR Industry Advisory Committee

• Philippe Sanseau, GlaxoSmithKline, UK

• Wendy Filsell, Unilever R&D, UK (Vice Chair)

• Angel Pizarro, Amazon Web Services, USA

• Jakob de Vlieg, Bayer CropSciences Innovation Center, Belgium

• Martin Ebeling, Hoffmann‐La Roche, Switzerland

• Anita Eliasson, Biocomputing Platforms Ltd, Finland

• Mark Forster, Syngenta, UK (Chair)

• Montserrat Vendrell, Biocat, Spain

• Natalia Jiménez Lozano, Bull and Atos, Spain

• Iain Hrynaszkiewicz, Nature Publishing Group ‐Macmillan, UK

• Claus Stie Kallesøe, Gritsystems A/S, Denmark

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Page 19: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

Industry Advisory Committee

Page 20: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

Public data: a foundation for  innovation

• Supporting Europe’s SMEs that build services on top of the public bioinformatics resources – understanding impact

• ELIXIR Core Resources and Named Services• Facilitating integration through Pilot Actions  

Page 21: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

Innovation and SME programme

Copenhagen, 24‐25 November 2014 

• Focussed on pharma and ELIXIR resources for drug discovery 

Wageningen, 18‐19 March 2015

• Data‐driven growth in the agri‐food industries

Basel, 9 June 2015

• Pharma and biotech 

Future events?

• Marine informatics 

• HPC suppliers

Page 22: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

Benefit of ELIXIR to industry ‐ supplier

• The life science sector as a consumer of HPC is already high and set to increase further

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Page 23: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR industry distribution channel 

• Mailing list of around 200 companies and SME Associations

• Events, news and industry/academia funding opportunities from across ELIXIR 

• Content, reach and frequency to expand through 2015

Page 24: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

ELIXIR webinars

• Regular series of updates from ELIXIR 

• Typically 3rd Wednesday of month

• 30 minute talk: 30 min questions 

• Future webinars:

• Data and Software carpentry ‐ Aleksandra Pawlik

• Marine metagenimics: towards user centric services –Nils Peder Willassen

• Run using WebEx ‐ for live or recorded viewing

• Full programme: elixir‐europe.org/webinar

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Page 25: Introduction to ELIXIR · ELIXIR webinars • Regular series of updates from ELIXIR • Typically 3rd Wednesday of month • 30 minute talk: 30 min questions • Future webinars:

www.elixir‐europe.org

Thank you