Introduction to Health Research for Ayurveda, Siddha and Unani Teachers

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    Introduction to

    Health Research Methods

    &A discussion on issues in

    Ayurveda, Siddha and Unani

    research

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    What we will look into

    Basic research methods in todays

    practice

    The gap between the fundamentals ofA.S.U. and the available research

    methods

    Required modifications A couple of examples

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    Before we enter

    The chorus is A.S.U. need to be moreevidence-based

    But A.S.U. systems were born out of attemptsof going beyond the body(after perfecting it)

    Unchanged concepts (over millenniums) ....

    Somewhere got interrupted

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    One Word Can SaveYour Life: No! - New

    research shows how

    some common testsand procedures arent

    just expensive, but

    can do more harmthan good.

    http://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.htmlhttp://www.thedailybeast.com/newsweek/2011/08/14/some-medical-tests-procedures-do-more-harm-than-good.html
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    "From the Vedas we learn a

    practical art of surgery,

    medicine, music, house

    building under which

    mechanized art is included.They are encyclopedia of

    every aspect of life, culture,

    religion, science, ethics, law,

    cosmology andmeteorology.

    William James (18421910)

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    Research defined

    Research is an organized and systematic

    way to find answers to questions

    WhatWhen

    Why

    Where

    Who

    How

    Research is a creative process

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    Research what is it all about?

    Central to the scientific enquiry.

    Seeing what others see and findingwhat others dont.

    Purpose: to add to knowledge

    that will better the lives of people

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    Research is a scientific process

    There is a need to demystify the scientific process. Scientific Inquiry is basically a potentiation of common

    sense ,which is one of the most equitably distributedhuman gifts.

    As Einstein said The whole of science is nothing morethan a refinement of everyday thinking.

    In a sense ,most of us conduct some research in our

    daily life.(e.g) ,if we want to buy a car in a proper way, wecollect information about the models anddealers,analyse it then try to reach the scientificconclusion on which one to buy.

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    Health Research

    Healthmost vital part of human life

    Health research & Medical research

    Cornerstone of all the advancements

    Health for all or Millennium

    Development Goalsonly through proper

    research

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    What health research has

    achieved so far

    Small pox

    Rheumatic fever & Rheumatic heart

    disease

    Iodine deficiency

    Tobacco use & cancer

    HIV/AIDS SARS/Avian flu/Swine flu

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    Is Health Research a luxury?

    Should Countries with scarce resources doresearch ?Yes

    Because we are a poor country , wecannot afford not to do research .

    (Jawaharlal Nehru) Clinical research needed, but with

    honest intentions: Harsh Vardhan

    Health researchA vital investment

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    Research provides the reliableevidence

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    Definition of levels of evidence and

    grading of recommendation

    Level Type of evidence available from Grade

    I a Meta-analysis of RCTsA

    I b At least one RCT

    I I a At least one well-designed controlled study withoutrandomization

    BI I b At least one other type of well-designed quasi-

    experimental study

    III Well-designed non-experimental descriptivestudies

    IV Expert committee reports or opinions and/or clinical

    experience of respected authoritiesC

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    Health research in India

    Since more than 2000 years

    1911 to 2011 (IRFA to ICMR)

    DHR - 2007 For mariginalized communities - priority

    Health research in India is poor: The

    Lancet * Research to achieve healthcare for all in India

    0.4% in 1988 to 1.8% in 2008*The Hindu, 04.04.2011

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    Research

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    Research in CCRAS

    Basic research

    Clinical research

    Drug research Literature research

    New drug development

    Collaborative research

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    Tools for health research

    Epidemiology

    Measures of disease frequency

    Causations & Associations

    Validity & reliability

    Study designs etc.,

    Biostatistics

    Descriptive statistics

    Sample size

    Tests of significance etc.,

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    Types of health research

    Basic and applied

    Empirical and theoretical

    Qualitative and quantitative

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    Types of Research Studies

    Research studies can be classifiedas:

    Wellness typeCausation type

    Disease type

    Prognosis type

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    Choosing a Research Topic

    FINER*Feasible

    InterestingNovel

    Ethical

    Relevant* Hulley et al, 2001

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    Study designs

    1. Different questions require different

    types of Study Designs.

    2. It is essential to understand the

    structure of different Study Designs

    3. Choosing the correct study design is

    crucial to the success of the Research

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    Epidemiologic Study Designs

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    Research cycle

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    The life cycle of epidemiological

    investigations:

    The never ending story

    Identifying

    data needs

    Spelling out the

    research question

    Formulating the

    study objectives

    Planning the

    analysis

    Preparing data

    collection instruments

    Analysing data

    Drawing conclusions

    Formulating

    recommendations

    Involving the

    programme

    Collecting data

    Here we

    go again

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    Research question spells out the local

    public health problem

    Problem in district Xamong the populationreached levelduring

    Note: The statement specifies: What

    How much

    Who

    Where

    When

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    Good research & Bad research

    There is only one type of research - goodresearch .

    Bad research does not deserve the name -Research

    Badly done research is utter waste of time ,money and effort; it is unethical as it exposesresearch subjects to the inherent risk ofexperimentation with no reward to them ,to

    others or communities

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    Poor medical research is a

    SCANDAL!*

    Due to ignorance or willingly!

    Fear of Epidemiology / Biostatistics

    Unprofessional, unethical & unacceptable

    Very common!?

    *BMJ, 1994;308:283-284

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    Flawed research

    A triple waste

    Researchers

    Participants and the system!

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    To lose ones health renders science null,

    art inglorious, strength unavailing, wealth

    useless and eloquence powerless

    Herophilus, 300 BC

    Lets take up the challenge &

    RESPONSIBILITY!

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    Oilbath is the key to good health

    Be sure to take oilbath weekly

    Oilbath keeps you healthy

    Take regular oilbath

    Oilbath prevents &cures many ailments

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    Hypothetical Research Question

    Your mission:

    Reduce the incidence of DPN

    Your belief:

    Regular oilbath is the key to good health

    Your hypothesis

    Regular exercise decreases the risk of DPN

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    Example of a Cross-Sectional Study

    Association between regular oilbath and

    DPN in the among DM

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    Cross-sectional Study

    Sample of Population

    Oilbath + Oilbath -

    Prevalence of

    DPN

    Prevalence of

    DPN

    Time Frame = Present

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    Cross-sectional Study

    Regular oilbath

    + -

    D

    P

    N

    +

    - 90

    10 90

    10

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    Case-Control Study

    Patients with DPN

    Patients w/o DPN

    PresentPast

    Regular OILBATH +

    Regular OILBATH +

    Regular OILBATH -

    Regular OILBATH -

    Cases

    Controls

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    Example of a Case-Control Study

    Are those with DPN less likely to haveOILBATH regularly?

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    Prospective Cohort Study

    Regular

    OILBATH -

    Regular

    OILBATH +

    No DPN

    DPN

    DPN

    No DPN

    Present Future

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    Example of a Cohort Study

    To see the effects of regular

    OILBATHon DPN in a DM population

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    Experimental Studies

    Clinical trials provide the gold

    standard of determining the

    relationship between OILBATHand

    prevention of DPN.

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    Clinical Trial

    Study

    Population

    Treatment

    Group

    Control

    Group

    Outcomes

    Outcomes

    R

    a

    n

    d

    o

    m

    iz

    e

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    Clinical Trial

    Study

    Population

    R

    a

    nd

    o

    m

    iz

    e

    OILBATH

    No OILBATH

    DPN

    No DPN

    DPN

    No DPN

    E id i l i l St di

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    Epidemiological Studies:

    Summary

    Cross-Sectional

    Case-Control

    Cohort RCT

    Cost + ++ +++ ++++

    Duration + ++ +++ +++

    SampleSize

    Varies Small Large Varies

    Incidence,Prevalence

    Prevalence None Incidence Incidence

    MultipleOutcomes

    Yes No Yes Yes

    Bias Prone Yes Yes No No

    Causality No No No Yes

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