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Introduction to Mendelian Genetics. Genetics: The study of heredity Heredity: How traits are passed down generation to generation History: Gregor Mendel is known as the father of genetics. Gregor Mendel/1850’s: Austrian monk Study mathematics and botany at the University of Vienna - PowerPoint PPT Presentation
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Introduction to Mendelian Genetics
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• Genetics:– The study of heredity
• Heredity:– How traits are passed down generation to
generation• History:
– Gregor Mendel is known as the father of genetics
• Gregor Mendel/1850’s:– Austrian monk– Study mathematics and botany at the
University of Vienna– Use both of these areas of study to analyze
genetic crosses using pea plants.
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Mendel worked with 7 pea plant traits:
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Mendel’s experiments:
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Important terms to know:• Gene:
– A segment of DNA that codes for a specific protein/trait.
• Allele:– A specific form of a gene
• Dominant:– The overpowering form of a gene– Occurs most often in a population– Represented by a capital letter
• Recessive:– The weaker form of a gene– Occurs less often in a population– Represented by a lower case letter
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Important terms to know:
• Phenotype:– A physical trait that you can see– Examples in peas: tall, short, wrinkled,
smooth• Genotype:
– The genetic make up /gene combination– Three types of genotypes:
• RR…..Homozygous dominant• Rr……Heterozygous• rr……. Homozygous recessive
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The law of dominance
• Simply stated: – Anytime a dominant allele is present the
dominant trait will be seen, it overpowers the recessive allele.
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• The ability to roll your tongue is dominant over the inability to roll your tongue.– Tongue roller …. T– Non tongue roller…t– Homozygous Dominant:
• TT• Tongue roller
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-Heterozygous•Tt•Tongue roller
-Homozygous Recessive•tt•Nontongue roller
Karyotype
- A diagram created from a picture of a person’s actual chromosomes.
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Use of the karyotype:
• Used to determine if a person inherited a certain gene or genetic disorder
• Used to determine the chance of passing a gene or genetic disorder on to their child
• Used to determine the sex of a child.
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It’s a male:
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Why?
XY
It’s a female:
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Why?
XX
Down Syndrome
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Edward’s Syndrome
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Creating a karyotype:
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-Look at the length of the chromosome
-Look for the position of the centromere
-Look at the repeating pattern of light and dark bands representing genes
-Look at the specific genes which have been identified and mapped/labeled through the Human Genome Project.
Punnett Squares
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A mathematical method to determine the chance of producing an offspring with a specific trait.
1 Trait Crosses
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Purple pea blossoms are dominant over white blossoms
Heterozygous purple flower crossed with another Heterozygous purple flower
Results:
Genotypic ratio:
- 25% BB - 50% Bb - 25% bb
Phenotypic ratio:
-75% purple -25% white
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In rabbits black fur is dominant over tan fur.
Cross a Homozygous dominant black fur male with a Homozygous recessive tan fur female.
2 trait crosses
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Yellow peas (Y) are dominant over green peas (y). Green pea pods (G) are dominant over yellow pods (g).
Cross a Heterozygous green pea pod, Heterozygous yellow pea with another Heterozygous green pea pod, Heterozygous yellow pea
GgYy x GgYy
2 trait cross
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In guinea pigs black fur is dominant over white fur and smooth fur is dominant over rough fur.
Cross a Homozygous recessive white, Heterozygous smooth fur female with a Heterozygous black fur, Homozygous dominant smooth fur male.
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