Invitation to Multimodal Medical Imaging

For Experimental and Clinical Research

Collaboration Center for Medical Innovation

Intellectual Property Management Division

Medical Photonics Research Center

Translational Research Center

Hamamatsu University School of Medicine

Imaging Research at Hamamatsu University School of Medicine

Hamamatsu University School of Medicine has been focusing for over 20 years on basic experimental as well as clinical medicine using the leading-edge optical technologies (through exchanges with world-class companies). Currently, "Medical Photonics", the state-of-the-art researches for basic and clinical medicine employing optical technologies, is one of the major characteristics of the university.

Our university has multimodal research equipment and environments for Medical Photonics. A large number of researchers and doctors are engaged in diagnostic study on a wide variety of clinical conditions using optical technologies, pharmacokinetic study, drug discovery, and development of medical devices using imaging technologies.

Meanwhile, Translational Research Center ("TR Center") was established inside the University Hospital to allow Phase I clinical trial (�rst-in-human) in 2002. The Center serves as a bridge between animal study and human use, and has worked with pharmaceutical companies to actively conduct clinical trials.

Our university introduced animal MRI scanners, animal CT scanners, clinical PET-CT scanners, cyclotrons, and GMP-compliant hot labs from 2010 to 2011. At the same time, we also expanded the RI Experimental Animals Institute and established rental labs and the Collaboration Center for Medical Innovation. Now, we are set up to support research using imaging technologies that would serve as a bridge between experimental research and clinical trial (translational research).

Our university is a unique base for imaging technology research since it has equipment and facilities that allow study of small animals, primates, and humans in series, as well as researchers to carry out these studies. We hope that the equipment and facilities will be widely used in drug discovery using imaging technologies, diagnostic study on clinical conditions, and development of image processing technologies and also medical devices.

Imaging Facilities

� Imaging modalities are gathered in one place

� Clinicians and researchers work together in research projects

� Study can be conducted in series from experimental to clinical levels

� Active engagement in research and development of medical devices

Features of imaging research at Hamamatsu University School of Medicine

Point 1 All imaging facilities are inside a university campus

Collaboration Center for Medical Innovation

The Collaboration Center for Medical Innovation was established in April, 2011 as a one-window for industry-academic collaboration and medical-engineering collaboration. The Center includes the PET-CT building and the cyclotron building. Imaging devices in the university used with small animals and humans (MRI scanners for research, CT scanners, and animal PET scanners) are managed by this Center. The Center is also the core facility for "Hamamatsu Medical and Engineering Technology Innovation Core" which is a project to develop a local industry-academic collaboration base.

Medical Photonics Research Center

In April, 2011, the former Photon Medical Research Center and the former Molecular Imaging Frontier Research Center were integrated into the Medical Photonics Research Center. A wide variety of medical research is conducted using optoelectronics and electromagnetic waves with humans and model animals.At this Center, advanced research is now being conducted including: life phenomenon study through optical and molecular imaging at all developmental levels from cells to individuals; development of diagnostic techniques and labeling agents for clinical diagnoses using the imaging method, investigation of causes of diseases by the Omix method; and development and improvement of optical tumor treatment methods.

Experimental Animals Institute

The Experimental Animals Institute was established in 1979 to conduct animal study as experimental medical research. The facility not only provides specialized knowledge to researchers but also contributes to education through lectures on laboratory animal science and graduation thesis research. At the same time, the facility contributes to promoting the �eld of laboratory animal science by developing mutant mice as human disease-model animals by a uniquely developed method and providing them to researchers. One of the recent focuses now is breeding of common marmosets, and the facility is promoting the use of them at the school. At the facility, mice, primates, and animals in between are used in research.

Translational Research Center (TR Center)

Locations of Imaging Facilities and University Hospital

The Translational Research Center (TR Center) was established in March, 2002 as a facility specialized in clinical research in the University Hospital. At this Center, clinical trial (Phases I and II) for drug discovery through industry-academic collaboration and exploratory clinical trial to apply results of animal study to clinical trial are conducted. In April, 2011, GMP-compliant hot labs and clinical PET-CT scanners were introduced to the Center, enabling it to conduct clinical trials using imaging technologies. This facility was established owing to the grant from Hamamatsu Photonics K.K. (HAMAMATSU).

The PET-CT building is adjacent to the Radiology Department of the University Hospital and is connected with it via a hallway. The TR Center that uses clinical PET-CT scanners for clinical trials is located in front of the PET-CT building. Also, the cyclotron building for cell and animal research is adjacent to the Medical Photonics Research Center.

N P TR Center

P

P

Hamamatsu University School of Medicine crossing

P

University Hospital

Labs

Faculty of Nursing building

Administration building

Library

Lecture and practicum building

Welfare facility building

* All imaging facilities are located within a 5-minute walking distance from the University Hospital.

1 2

PET-CT building Cyclotron building

Cyclotron building

Medical Photonics Research Center

Outline of Hamamatsu University School of Medicine (as of May, 2011)

Foundation June, 1974

President Satoshi Nakamura, MD, PhD.

Department of Medicine Faculty of Medicine, Faculty of Nursing, and University HospitalDepartments Doctoral Degree Program in Graduate School of Medicine Master's Degree Program in Graduate School of Nursing

Number of 1,077 (971 undergraduates)students

Number of 1,174 (324 researchers) academic sta�

University 23,518,000,000 yen (FY2010 closing �gure)�nances

PET-CT building

Experimental Animals Institute

Field of view: approximately 10 cm of diameter, and approximately 10 cm of depth

Spatial resolution: 1.6 mm for PET, 0.5 mm for SPECT, and 50 μm for CT

*1 Since it is a clinical machine, animal testing can be carried out using a clinical imaging protocol.

Speed: as fast as 0.8 seconds per rotation

Output: up to 350 mA (120 kV)

Scan slice thickness (mm): 0.625, 1.25, 2.5, 5.75, and 10

Static magnetic field homogeneity: 0.25 ppm (40 cmDSV)

Maximum gradient magnetic field strength: 50 mT/m, and slew rate (SR) of 150

3 4

Imaging Modalities

PET/SPECT/CT system* at cyclotron building

PET, SPECT, and CT scanners are installed on one system. It can produce images in various modalities without having to move a subject animal. It can also fuse images of di�erent modalities.

16 channel X-ray CT scanner* at experimental animals institute

It is a multi detector-row CT (MDCT) scanner with 16 detector rows that realizes high image quality by a super high-pitch helical rotation of 50 cm in approximately 10 cm and by use of the Clear View Image Reconstruction (CViR) technology. With a sophisticated workstation and 3D application, it can quickly create 3D images and conduct a wide variety of analysis.

3T MRI system* at experimental animals institute

Magnetic �eld strength of 3T allows acquisition of high quality images. It has coils exclusively developed for small animals (rats and mice); therefore, it can create images of various sizes of animals from small animals to primates.

Hot lab for fundamental research and development at cyclotron building

A hot lab is a device for automatically synthesizing radioactive drugs to be used in PET scans by labeling radionuclides, generated by a cyclotron, on drugs.

This cyclotron system provides radioisotopes that are necessary for production of RI (radio isotope) labels (18F-FDG) for PET scans. It has two beam ports that can emit at the same time, and four targets can be attached to each port.

For experimental study and non-clinical study

For Clinical trial

GMI, "FX System" PET resolution: 4.2 mm FWHM @ 1 cm in the cross-section direction, and 4.7 mm FWHM @ 1 cm in the axis direction

CT scan slice thickness (mm): 0.6, 0.75, 1.0, 1.5, 2, 3, 4, 5, 6, 8, and 10

PET/CT system* at PET-CT building

This system is an integration of the 16-slide CT scanner "SOMATOM Emotion 16" and advanced PET function based on sensitive and high resolution LSO-HiRez detection. This system can handle a wide variety of activities such as phosphorus level analysis and research in the �elds of PET and/or CT scans of tumors, cranial nerves, and circulatory organs.

SIEMENS, "TruePoint Biograph 16"

Miscellaneous

Equipment available for external use

Acceleration energy: 12 MeV for protons and 6 MeV for deuterons

Maximum beam current: 100 μA

Ultra-small cyclotron for PET scanner at cyclotron building

Sumitomo Heavy Industries, "CYPRIS HM-12S"

GE, "BrightSpeed Elite SD" clinical machine *1 Static magnetic field homogeneity: 0.25 ppm (40 cmDSV)

Maximum gradient magnetic field strength: 50 mT/m, and slew rate (SR) of 250

3T MRI system at university hospital

It is the highest-end model of the GE 3T MR. It provides maximum reduction of image unevenness attributed to a magnetic �eld and can carry out high-speed and high-de�nition imaging of not only the head but also the entire body. It also allows vascular pathology assessment through 3D blood �ow analysis, higher brain function analysis through brain function imaging, and metabolism analysis through MR spectroscopy.

GE, "Discovery MR750"

Animal preparation / feeding rooms* at cyclotron building / experimental animals institute

There is an animal preparation room for feeding experimental animals in the I management section of the cyclotron building. Time changes in individual animals can be observed in this building.

GE, "Signa HDxt 3.0T" clinical machine *1

GMP-compliant hot lab at cyclotron building

A hot lab is an automatic drug synthesizer that has met the good manufacturing practice (GMP) standard for experimental drugs with regard to manufacturing equipment and quality control of pharmaceuticals. At the university, this system can be used in clinical trials and synthesis of drugs to be used in microdose approach.

Sumitomo Heavy Industries, "HOT CELL"Universal Giken, "4-Consecutive Hot Cell"

Luminescence and �uorescence imaging systems at RI management section of the cyclotron building

Caliper, "IVIS 200" (left)It is a high-performance in-vivo luminescence imaging system. It can carry out ultrasensitive luminescence imaging and 3D imaging of regular sensitivity.

CRi, "Maestro" (right) It is an in-vivo multispectral imaging system exclusively designed for �uorescence imaging. It detects target areas marked with �uorescence with high sensitivity while eliminating intrinsic �uorescence.

Sumitomo Heavy Industries, "Multipurpose synthesizing equipment"

Caliper IVIS 200 CRi Maestro

FDG -PET / CT images of an arteriosclerosis model rabbit (PET probe: 18F-FDG)

7 months 9 months 11 months 13 months 15 months

A myocardial perfusion image of a rabbit created by the 99mTc-MIBI SPECT

Hemodynamics analysis of a rabbit heart

In FY2011, equipment marked with an asterisk (*) became available for use by external parties without requiring them to enter into a joint study or contracted study agreement. Please refer to the attached

document for usage fees. We are able to give you advice on device selection or radiography methods for those who are carrying out imaging for the first time.

Note that use of equipment without the asterisk still requires entering into a joint study or contracted study agreement with our university.

5 6

From Experimental Study to Clinical Trial

Hamamatsu University School of Medicine has imaging modalities that can handle all levels of studies from Experimental to clinical trials, lecture and research centers for experimental studies, the University Hospital for clinical trials, the Clinical Trial Center for clinical trials, and TR Center. Therefore, complete research and development of pharmaceuticals and medical devices can be carried out at our university.

Hamamatsu University School of Medicine has been designated as a specialist training institute in the Japan Advanced Molecular Imaging Program (J-AMP) implemented by the Ministry of Education, Culture, Sports, Science and Technology. Our university is now promoting training of PET researchers who use small animals, primates, and other sizes of animals in between to develop imaging probes and design imaging technology applications.Our university works together with local companies and medical institutions to train the next-generation PET researchers. More specifically, we trains doctors and researchers who can use imaging technologies to contribute to medical practice and translational research.

Base for Molecular Imaging Specialist TrainingSupport for application of imaging technologies to clinical settings �

This network was created to support clinical trials of new drugs. The members of the network are Hamamatsu University School of Medicine, Seirei Hamamatsu General Hospital, Seirei Mikatahara General Hospital, Hamamatsu Medical Center, Iwata City Hospital, Enshu Hospital, and the Hamamatsu Medical Association. The member hospitals are all located in the western part of Shizuoka prefecture.

[Features of the network] � Central Institutional Review Board (IRB) (all examinations at a single IRB)

� Single contact point (the office makes all necessary adjustments among facilities and controls all information)

� Easy access (all facilities can be accessed within 1 hour from Hamamatsu station)

[Establishment] October, 2011

Chairman: Masahiro Takigawa, Director of Hamamatsu University School of Medicine

[Size of the network] 3,737 beds at six medical institutions

[O�ce] Center for Clinical Research, Hamamatsu University School of Medicine

Totoumi Clinical Trial NetworkSupport for application of imaging technologies to clinical settings �

Lecture on PET at the graduate school

Experimental study Non-clinical studyApplication

for approval

Manufacturing and saleClinical TrialExploratory

Clinical Study

Exploration of target molecules for drug discovery

Optimization of seed and lead compounds

Pharmacology study

Pharmacokinetic study

Safety pharmacology study

Toxicity study

Phase I Phase II Phase III Phase IV

Center for Clinical ResearchTranslational Research Center (TR Center)University Hospital

Faculty of Medicine (basic and clinical lecturers)Medical Photonics Research CenterResearch Center for Child Mental DevelopmentCollaboration Center for Medical InnovationUniversity Hospital

Number of joint and contracted studies (FY2011)

Features of clinical trials at Hamamatsu University School of Medicine

Has rich achievements and experience in clinical trials

Can conduct experimental studies and clinical trials (from Phase I to IV) in sequence

Can conduct early exploratory clinical studies and clinical trials (Phase I) on contract

Can conduct investigator-initiated trials

Has GMP-compliant hot labs

Can give advice on design and development of imaging probes

Has access to a local clinical trial network

Exploratory clinical study

POC study

Microdose approach

Number of clinical trials

Humans

Shizuoka Prefecture

For Tokyo

Hamamatsu

1 hour and half from Tokyo or Osaka by Hikari Tokaido Shinkansen

For Osaka

Central medical institutions are all located within a

9 km radius

Point 2 Experimental study, animal study, and clinical trial can be conducted in series.

Cells and animals

Joint studies 46

Contracted studies 5,067

General 54

Clinical trials 253

Pathological examination 4,760

FY 2010 253

FY2009 217

FY2008 190

FY2007 177Brain blood flow image of rat by 99mTc-HMPAO

TR Center – Testing Room TR Center – Trial Room

Development of Medial Devices through Medical-Engineering Collaboration

One of the characteristics of Hamamatsu University School of Medicine is active and frequent engagement in devel-opment of medical devices through collaboration with companies.In 2009, the research projects "the practical development of medical photonics-based products" in Hamamatsu University School of Medicine was selected as Privileged Area for Medical Research and Development by the Japanese Cabinet O�ce.Hamamatsu University School of Medicine is now engaged in joint research and development with companies with the goal of commercialization of new medical devices with imaging technologies.

[Projects of the Privileged Area for Medical Research and Development]

Development of a surgical navigator, a stereo endoscope, and an ultrasound probe to assist an minimally invasive endoscopic surgery

ResearchersSeiji Yamamoto (Professor, Medical Photonics Research Center)Hiroyuki Mineta (Director and professor of the Department of Otorhinolaryngology, University Hospital)

Cooperating companies

Nagashima Medical Instruments, Amelio, Pulstec Industrial, NST, Zodiac , and Honda Electronics

ResearchersYasuomi Ouchi (professor, Medical Photonics Research Center)Yasuhiro Magata (professor, Medical Photonics Research Center)

Cooperating company Hamamatsu Photonics (HAMAMATSU)

ResearchersKazuo Umemura (Professor of pharmacology, Department of Medicine)Teiji Nakayama (Director of the Emergency Care Center, Hamamatsu Medical Center)

Cooperating company Hamamatsu Photonics (HAMAMATSU)

Surgical navigator Stereo endoscope system

[Other Projects]

Development of a system to automatically measure lymphatic pressure in extremities using a near infrared light detection technology

Development and clinical assessment of an optical mammography system for breast cancer diagnosis

Research and Development of a next-generation PET diagnosis system for contributing to treatment of mental illnesses

Development of a colon cancer diagnosis system

Development of a molecular imaging system with a mass microscope

Development of a laser thrombolysis treatment systemLaser beam

Blood vessel walls

Optical fiberCatheter

* A part of the FY2010 Regional Innovation Creation R&D Program (Ministry of Economy, Trade and Industry

* A part of the industry-university-government collaboration research and development project using a FY2011 grant from the Shizuoka Organization for Creation of Industries

Development of a 3D X-ray assessment system for use in outpatient care

Development of a point-of-gaze detector for autistic infant diagnosis

Development of a high-accuracy, super wide field fiber confocal microscope

The Hamamatsu and Higashi Mikawa regions are strong in the field of optical and electronic engineering, which can provide basic technolo-

gies for almost any kind of industry. In a regional innovation strategy support program called "Hamamatsu and Higashi Mikawa Life Photon-

ics Innovation" that focuses on the field of optical and electronic engineering, these two regions are the bases for promotion of the health

and healthcare industry, which is one of the four industries that are becoming essential as new leading industries.

The base offers opportunities for doctors and local companies to exchange information and for local companies to see the site of medical

practice as a framework for creating a chain of continuous innovations by integrating high-level engineering and development skills

accumulated in Hamamatsu area, whose strength is production and manufacturing, and needs in the fields of medical practice and

medicine.

Hamamatsu Medical and Engineering Technology Innovation CoreFor promoting and supporting industry-academic collaboration

Industry-academia exchange of information Site visit and discussion in the university hospital (surgical unit / laboratory examination unit)

O�ce

2nd �oor, PET-CT building, Collaboration Center for Medical Innovation, HamamatsuUniversity School of Medicine1-20-1 Handayama, Higashi-ku, Hamamatsu city, Shizuoka, Japan 431-3192

Phone / Fax : +81-53-435-2438E-mail address: ikollabo@hama-med.ac.jp

7 8

Point 3 Active engagement in research and development of medical devices through medical-engineering collaboration

ResearchersHarumi Sakahara (Director and professor of the Department of Radiology, University Hospital)Hiroyuki Ogura (Vice-Director and assistant professor of the Department of Breast Surgery, University Hospital)Norihiko Shiiya (Director and professor of the Department of Breast Surgery, University Hospital)

Cooperating companies Hamamatsu Photonics (HAMAMATSU)

Researchers Hiroshi Koyama (Assistant professor of the Department of Orthopedics, University Hospital)Hironobu Hoshino (Vice-Director and associate professor of the Department of Orthopedics, University Hospital)Seiji Yamamoto (Professor, Medical Photonics Research Center)

Cooperating company Kamijima Denkosha

Researcher Naoki Unno (Director and associate professor of the Department of Vascular Surgery, University Hospital)

Cooperating companies NST, Hamamatsu Photonics (HAMAMATSU) and Zodiac

3-D

Sitting

Recumbent

Industry-Academia-Government Collaboration System University Hospital (as of May, 2011)

Inquiries

Collaboration Center Committee (monthly meeting)

About industry-academia collaboration, joint or contracted research, translational research, and use of devices

About clinical testing and trials

At Hamamatsu University School of Medicine, various types of knowledge such as result of research, needs in medical practice, intellectual property, know-how, and implicit knowl-edge that is generated in daily activities such as education, research, and medical exami-nation are treated as valuable assets.Our university believes contribution to the future of human health and healthcare is university’s mission. Therefore, it serves as an educational, research, and medical examina-tion institution while promoting industry-academia-government collaboration such that the knowledge described above can be brought back to society through collaboration with other universities and companies. The Intellectual Property Management Division (IPMD) and the Collaboration Center for Medical Innovation (Collaboration Center) play the central role in the abovementioned industry-academia-government collaboration. For realization of this collaboration, we have unique human resource assignments in which the vice-president of the IPMD serves concurrently as the director of the TR Center, and a doctor with rich clinical experience as well as experience in medical device develop-ment is now serving as the director of the Collaboration Center.Because of this personnel allocation, the collaborative activities are always closely related to the fields of medical practice and a large number of clinical doctors can participate in a project based on industry-academia or medical-engineering collaboration.

Satoshi NakamuraPresident, Hamamatsu University School of MedicineDirector of the Intellectual Property Management DivisionFrom Saga Prefecture and a Keio University graduate

He became an assistant in the Second Department of Surgery of the Hamamatsu University School of Medicine. After serving as an assistant professor and then a professor, he became the director of the University Hospital. He has been the president of the Hamamatsu University School of Medicine since April, 2010.

Seiji Yamamoto

Professor, Hamamatsu University School of MedicineDirector, Collaboration Center for Medical InnovationResearch Supervisor for the Hamamatsu Medical-Engineering Innovation Core

Graduated from Hamamatsu University School of Medicine. Neurosurgeon.After working at Yaizu City Hospital and Cornell University, he became an associate professor at the former Photon Medical Research Center (currently the Medical Photonics Research Center) in 2000.He became a Professor in 2012.

The Collaboration Center Committee consists of members engaged in operations related to industry-academia-government collaboration (president of the university / director of the IPMD director of the Collaboration Center, director of the TR Center, et al.). This committee provides opportunities to all the members to check internal / external trends in industry-academia-government collaboration, check other members' operational progress, and discuss future actions for the university.

The Collaboration Center works together with the IPMD and serves as a one-window for implementa-tion of industry-academia collaboration and medical-engineering collaboration inside and outside the university. The Center provides support for development and commercialization of medical devices, answers questions about pharmaceutical regulations, collects needs for Clinical practice, and suggests partners in medical-engineering collaboration.

Hospital designations Approved as an advanced treatment hospital (March, 1995)

Designated as a regional disaster hospital (December, 1996)

Designated as a tuberculosis care institution (June, 1998)

Designated as a regional perinatal medical center (October, 1998)

Designated as an open system hospital (May, 2005)

Designated as a regional cancer care hospital (January, 2007)

Designated as an intractable disease treatment hospital (April, 2007)

Designated as a clinical trial medical center (July, 2007)

Designated as a Shizuoka hospital for collaboration in liver disease medical examinations (March, 2009)

Collaboration Center for Medical Innovation Phone: +81-53-435-2677 E-mail address: collabo@hama-med.ac.jpIntellectual Property Management Division Phone: +81-53-435-2230 E-mail address: chizai@hama-med.ac.jp[Persons in charge] Kiriko Abe (assistant professor) Yuichiro Onodera (assistant professor)

Clinical Research Management Center at University Hospital Phone: +81-53-435-2850

Gastroenterology

Nephrology and diabetes

Neurology

Endocrinology and metabolism

Respiratory medicine

Hepatology

Cardiology

Hematology

Immunology and rheumatology

Clinical pharmacology

Psychiatry

Pediatrics

Dermatology

Radiology

Cardiovascular surgery

Thoracic surgery

Pediatric surgery

Breast surgery

General surgery

Upper alimentary tract surgery

Lower alimentary tract surgery

Liver, gallbladder, and pancreas surgery

Vascular surgery

Neurosurgery

Orthopedic surgery

Urology

Ophthalmology

Otorhinolaryngology

Obstetrics and gynecology

Anesthesiology and resuscitation

Oral and Maxillofacial surgery

Plastic surgery

Rehabilitation

Examination unit

Operation unit

Radiology unit

Material unit

Pathology unit

Emergency unit

Intensive care unit

Blood transfusion and cell therapy unit

Medical information unit

Endoscopy care unit

Blood puri�cation therapy unit

Rehabilitation unit

Pharmaceutical unit

Nursing unit

Clinical training center

Clinical research management center

Perinatal medical center

Chemotherapy unit

Gene therapy unit

Nutrition unit

Medical welfare support center

Cancer center

Intractable diseases information center

Liver disease counseling room

Infection control o�ce

Medical care safety management room

Tampopo class

Clinical departments Care units

Centers

Other

New hospital building (construction completed in June, 2009) Staff station Hospital room (with 4 beds)

Clinical needsMedical seeds

Company needsCompany seeds

University

Company

CompanyUniversity

Local government

Local government

CompanyHamamatsu Medical and

Engineering Technology Innovation Core

Collaboration Center for

Medical InnovationIntellectual Property

Management Division

Researcher (doctor)

Faculty of Medicine

Research centers

University Hospital

Clinical needsMedical seeds

Company needsCompany seeds

9 10

Foundation April, 1977

Director Masahiro Takigawa, MD, PhD.

Department See the list on the right

Number of beds 613

Number of healthcare personnel 1,169

Number of outpatients 1,194 (daily average in FY 2010)

Number of inpatients 486 (daily average in FY2010)

Hamamatsu University School of Medicine

Local Hospitals

University and institutions in other areas

One-windowfor Medical-Engineering

Collaboration

Ham

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Sch

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[Issued in] March, 2012[Issued by] Intellectual Property Management Division, Hamamatsu University School of Medicine

Hamamatsu University School of Medicine

Access and Location[By bus]Get on a bus from bus stop #13 at the bus loop outside the Hamamatsu station north exit, and get off at "Ika Daigaku Mae." The bus number is 50 (for City Hall, Yamanote, and Idai) and it takes approximately 40 minutes.

[By Shinkansen] *Only a few Hikari trains stop at Hamamatsu station.

From Tokyo to Hamamatsu: approximately 90 minutes by HIKARI, and approximately 120 minutes by KODAMAFrom Shin-Osaka to Hamamatsu: approximately 90 minutes by HIKARI, and approximately 120 minutes by KODAMA

[By car]From Tomei Expressway Tokyo interchange to Hamamatsu interchange: approximately 120 minutes From Tomei Expressway Nagoya interchange to Hamamatsu-Nishi interchange: approximately 45 minutes

Images in the cover page (in sequence from the left)• Mouse: Tumor imaging / SPECT-CT• Rat: Cardiac muscle imaging / PET-CT (18F-FDG)• Rabbit: Analysis of the hemodynamic status of the heart / MRI• Marmoset: Local FDG analysis of the brain / PET-CT (18F-FDG)• Cynomolgus monkey: Brain blood vessel MRA (MRA 2 slab)• Human: Serotonin receptor / PET-MRI (11C-DASB)

Hamamatsu station

Hamamatsu Castle

Hamamatsu Baseball Stadium

Hamamatsu Technical

High School

Takatsuka statio

Shinkansen

Sanaru Lake

Hamamatsu City Hall

Hamamatsu Medical Center

Tenryu-Gawa station

Tomei Expressway Hamamatsu interchange

Route 150

Tenryu River

Route 1

Tokaido Main Line

Kasa

i Kai

do

Shizuoka UniversityFaculty of Informatics and Faculty of Engineering

Hamamatsu City Rehabilitation Hospital

Tomei Expressway Hamamatsu-Nishi interchange

Tomei Expressway

Route 152

Route 257

Japan Air Self-Defense Force Hamamatsu Air Base

Hime Kaido

Aoi-Cho Hatsuoi-Cho

Handa Machi

Hamamatsu University School of Medicine

1-20-1 Handayama, Higashi-ku, Hamamatsu city, Shizuoka, Japan 431-3192Phone : +81-53-435-2677 E-mail address : chizai@hama-med.ac.jp