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CURRICULUM VITAE Dr. Mahendra Pratap Singh
Principal Scientist, Toxicogenomics and Predictive Toxicology Laboratory
Systems Toxicology and Health Risk Assessment Group
CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg
Post Box No. 80, Lucknow 226 001, Uttar Pradesh, India
Telephone: +91-522-2217626
E-mail: [email protected]; [email protected]
Date of Birth:
September 05, 1970
Education:
2000: Doctor of Philosophy (Biochemistry), CSIR-Central Drug Research Institute (University
of Lucknow), Lucknow, India
1993: *Master of Science (Biochemistry), University of Allahabad, Allahabad, India (Degree was
awarded in 1994 due to delay in academic session of the university)
1991:*Bachelor of Science (Chemistry, Botany and Zoology), University of Allahabad,
Allahabad, India
1988: *Intermediate (Biology, Chemistry, Physics, English and Hindi), Uttar Pradesh Board of
High School and Intermediate Education, Allahabad, India
1986: *High School (Science-2, Social Science, Mathematics-2, Biology, English and Hindi),
Uttar Pradesh Board of High School and Intermediate Education, Allahabad, India(*First division)
Employment/Research Experience:
2009*-to date: Principal Scientist, CSIR-Indian Institute of Toxicology Research, Lucknow,
India
2006-2009: Senior Scientist, CSIR-Indian Institute of Toxicology Research, Lucknow, India
2002-2006: Scientist, CSIR-Indian Institute of Toxicology Research, Lucknow, India
2000-2002: Research Associate, CSIR-Centre for Cellular and Molecular Biology, Hyderabad,
India
1997-2000: Senior Research Fellow, CSIR-Central Drug Research Institute, Lucknow, India
1995-1997: Junior Research Fellow, CSIR-Central Drug Research Institute, Lucknow, India* Merit promotion from Senior Scientist to Principal Scientist
Academic/Scientific Honors:
1984-1986: College Merit Scholarship, J. Inter College, Khapraha, Jaunpur, Uttar Pradesh, India
1986-1988: State Merit Scholarship, Government of Uttar Pradesh, India
1994: Qualified the CSIR-University Grant Commission (UGC) (India)-National Test for Junior
Research Fellowship and Eligibility for Lectureship (under the CSIR Fellowship Category)
1995: Qualified Graduate Aptitude Test in Engineering (GATE) Conducted by the Indian
Institute of Technology, Kanpur, India
2001: Awarded Research Associateship of the Indian Council of Medical Research (ICMR),
India
2001: Awarded Research Associateship of the CSIR, India
2012: Certificate of Excellence from the CSIR-Indian Institute of Toxicology Research,
Lucknow, India
2013: Award of Excellence from the CSIR-Indian Institute of Toxicology Research, Lucknow,
India
Area of Research Interest:
Biochemical and Molecular Toxicology & Neurobiology of Parkinson’s disease
Membership in Professional Societies:
Life Member, Indian Society of Cell Biology & Member, American Chemical Society
Recognized Guide/Co-Guide to Supervise Doctoral Students:
(1) Biochemistry, Banaras Hindu University (BHU), Varanasi, India (2) Life Sciences
(Biochemistry), Chhatrapati Shahu Ji Maharaj (CSJM) University, Kanpur, India (3)
Biotechnology, Jamia Hamdard, New Delhi, India (4) Biomedical Sciences (Biochemistry), King
George’s Medical University (KGMU), Lucknow, India (5) Biotechnology, Babasaheb Bhimrao
Ambedkar University, Lucknow, India (6) Biotechnology, Jiwaji University, Gwalior, India (7)
Pathology, Sarojini Naidu Medical College (SNMC), Dr. B. R. Ambedkar University, Agra,
India (8) Biotechnology, Deen Dayal Upadhyay (DDU) Gorakhpur University, Gorakhpur, India
(9) Biochemistry, Babu Banarasi Das (BBD) University, Lucknow, India (10) Biological
Sciences, Academy of Scientific and Innovative Research (AcSIR), India
Invited Member on the Editorial Boards:
(1) Journal of Theoretical and Experimental Pharmacology (2010) (2) Proteomics Insights
(2008-to date) (3) Annals of Phytomedicine (2012-to date) (4) ISRN Toxicology/ISRN
International Scholarly Research Network (2013-to date) (5) World Research Journal of Cell
Biology (Associate Editor, 2013-to date) (6) Frontiers in Pharmacogenetics and
Pharmacogenomics (Reviews Editor, 2013-to date) (7) Journal of Metabolomics (2014-to date)
(8) Behavioral Neurology (2014-2017) (9) Journal of Toxicology and Health (2014-to date) (10)
Research Journal of Aging (2014-to date) (11) Therapeutic Targets for Neurological Diseases
(2015-to date) (12) Journal of Hematology and Blood Disorders (2015-to date) (13) Heliyon
(2015-to date) (14) Journal of Toxicology and Forensic Cases (2015-to date) (15) International
Journal of Bioinformatics and Biological Systems (2015-to date)
Invited Guest Editor:
Two Special Issues for BioMed Research International (First Special Issue on
“Neurodegeneration: Etiologies and New Therapies” and the Second Special Issue on
“Neurodegeneration: Etiologies and New Therapies 2016”)
Invited Ad-hoc Reviewer of Scientific Journals:
(1) Indian Journal of Medical Research (2) Indian Journal of Biochemistry and Biophysics (3)
Proceedings of the National Academy of Sciences, India (Section B- Biological Sciences) (4)
Journal of Proteomics and Bio-informatics (5) Current Pharmacogenomics and Personalized
Medicine (6) Frontiers in Biosciences (7) Disease Markers (8) Expert Opinion on Drug
Metabolism & Toxicology (9) Proteomics (10) Journal of Proteomics (11) International Journal
of Cancer (12) Molecular Biology Reports (13) Drug News and Perspectives (14) Journal of
Cellular Biochemistry (15) Clinica Chimca Acta (16) Cancer Genetics and Cytogenetics (17)
Ecotoxicology and Environmental Safety (18) European Journal of Neurosciences (19) European
Journal of Pharmacology (20) Expert Review of Proteomics (21) Cellular and Molecular Biology
(22) Arabian Journal of Chemistry (23) Medical Hypotheses (24) Digestive and Liver Disease
(25) Journal of Neuroinflammation (26) Brain Research Bulletin (27) Neurotoxicity Research
(28) Food and Chemical Toxicology (29) Archives of Toxicology (30) Brain Research, (31)
Molecular Neurodegeneration (32) Pharmaceutical Biology (33) Scientific Reports (34) Human
and Experimental Toxicology (35) ACS Chemical Neuroscience (36) Oxidative Medicine and
Cellular Longevity (37) Neurochemical Research (38) Drug and Chemical Toxicology (39)
Cellular and Molecular Neurobiology (40) Journal of Environmental Biology (41) Journal of
Proteome Research (42) Neurochemistry International (43) Molecular and Cellular Biochemistry
(44) Evidence-Based Complementary and Alternative Medicine (45) Annals of Epidemiology
(46) Therapeutic Targets for Neurological Diseases (47) International Journal of
Occupational and Environmental Health (48) Molecular Neurobiology (49) BBA-Proteins
and Proteomics (50) Neurotoxicology (51) BioFactors (52) Tumor Biology (53) Letters in Drug
Design and Discovery (54) Interdisciplinary Sciences - Computational Life Sciences (55)
Neuroscience Letters (56) Journal of Neural Transmission (57) Neuropharmacology (58) Journal
of Chromatography B (59) Mutagenesis (60) Current Drug Targets (61) Journal of Chemical
Neuroanatomy (62) Journal of Neurophysiology (63) Dementia and Geriatric Cognitive
Disorders (64) Biomedicine & Pharmacotherapy (65) Oncotarget
Invited Ad-hoc Reviewer of Research Grants/Student Fellowships:
(1) Department of Biotechnology (DBT), India (2) Council of Science and Technology, Uttar
Pradesh, India (3) Dr. Hadwen Trust for Humane Research, United Kingdom (4) The Research
Council, Oman (5) Medical Research Council, South Africa (6) Department of Science and
Technology (DST), India (7) CSIR, India (8) ICMR, India
Invited Ad-hoc Reviewer of E-Book:
How Selegiline/(-)-Deprenyl Slows Brain Aging? (Bentham Science Publishers)
Grant-In-Aid Projects as the Principal Investigator:
1. Role of peroxiredoxin 3 and other redox sensitive proteins in pesticide-induced Parkinsonism
(Department of Biotechnology (DBT), India sponsored, 2018-2021)
2. An integrated approach to decipher the molecular mechanism of pesticide-induced Parkinsonism
(Science and Engineering Research Board (SERB), India sponsored 2017-2020)
3. Mitochondrial proteomics to unravel the role of novel proteins in cypermethrin-induced
nigrostriatal dopaminergic neurodegeneration (DBT, India sponsored, 2011-2014)
4. Neuroprotective potential of Cyp2d22 in pesticides-induced dopaminergic neurodegeneration:
Implications in antioxidants-mediated neuroprotection (DST, India sponsored, 2011-2014)
5. Effect of caffeine on microglial activation and secondary signaling mediators in maneb +
paraquat-induced Parkinson’s disease phenotype in mouse (DBT, India sponsored, 2008-2011)
6. Molecular mechanism of caffeine and nicotine mediated neuroprotection in MPTP-induced
Parkinson’s disease phenotype in mouse (DBT, India sponsored, 2005-2008)
7. Proteomics based approaches for the development of peripheral protein biomarkers and
assessment of contribution of selected environmental chemicals in the onset of Parkinson’s
disease (ICMR, India sponsored, 2004-2007)
8. Microarrays and proteomics based approaches to assess the modulation of multiple genes and
proteins involved in maneb and paraquat induced Parkinson’s disease phenotype in mouse (DBT,
India sponsored, 2004-2006)Grant-in-aid projects in which I was a Co-Principal Investigator (04)/ doctoral activity projects (03) are not included.
CSIR Networked/Supra-Institutional Projects as the Principal Investigator for Specific
Research Activity
1. Toxicogenomics of genetic polymorphism in Indian population to industrial chemicals for
development of biomarkers (10th Five Year Plan: CSIR, India Networked Programme, 2002-
2007)
2. Investigative toxicology: new paradigms (11th Five Year Plan: CSIR, India Supra-institutional
Programme, 2007-2012)
3. Integrated NextGen approaches in health, disease and environmental toxicity (INDEPTH) (12 th
Five Year Plan: CSIR, India Networked Programme, 2012-2017)
4. Neurodegenerative diseases: causes and corrections (miND) (12th Five Year Plan: CSIR, India
Networked Programme, Institutional Nodal, 2012-2017)
Students Awarded the Doctoral Degree (Fifteen)
(1) Dr. Suman Patel (CSJM University, Kanpur, India) (2) Dr. Abhai Kumar (DDU Gorakhpur
University, Gorakhpur, India) (3) Dr. Ashima Sinha (Jiwaji University, Gwalior, India) (4) Dr.
Virendra Singh (SNMC, Dr. BR Ambedkar University, Agra) (5) Dr. Ghanshyam Upadhyay
(BHU, Varanasi, India) (6) Dr. Seema Singh (KGMU, Lucknow, India) (7) Dr. Anand Kumar
Singh (BHU, Varanasi, India) (8) Dr. Sharawan Yadav (BHU, Varanasi, India) (9) Dr. Naveen
Kumar Singhal (Jamia Hamdard, New Delhi, India) (10) Dr. Manindra Nath Tiwari (BHU,
Varanasi, India) (11) Dr. Garima Srivastava (BHU, Varanasi, India) (12) Dr. Anubhuti Dixit
(BHU, Varanasi, India) (13) Dr. Sonal Agrawal (AcSIR, CSIR-Indian Institute of Toxicology
Research, Lucknow) (14) Dr. Ashish Singh (BHU, Varanasi, India) (15) Dr. Satya Prakash
Gupta (Submitted to DDU Gorakhpur University, Gorakhpur, India)
Students Currently Enrolled for the Doctoral Degree (Seven):
(1) Ms. Pratibha Tripathi (BBD University, Lucknow) (2) Mr. Abhishek Kumar Mishra (AcSIR,
CSIR-Indian Institute of Toxicology Research, Lucknow) (3) Mr. Manish Kumar Tripathi
(AcSIR, CSIR-Indian Institute of Toxicology Research, Lucknow) (4) Mr. Mohd Sami ur
Rasheed (AcSIR, CSIR-Indian Institute of Toxicology Research, Lucknow) (5) Ms. Saumya
Mishra (AcSIR, CSIR-Indian Institute of Toxicology Research, Lucknow) (6) Ms. Charul Rajput
(AcSIR, CSIR-Indian Institute of Toxicology Research, Lucknow) (7) Ms. Alika Sarkar (AcSIR,
CSIR-Indian Institute of Toxicology Research, Lucknow)
Students Worked in Grant-In-Aid Projects/Short-Term Research Activities (Six):
Junior/Senior Research Fellow: (1) Ms. Sonam Tripathi
Project Assistant Level-II: (1) Ms. Kavita Singh (2) Ms. Divya Verma (3) Mr. Saurabh Shukla
(4) Ms. Toolika Ram
Post-Doctoral Fellow: (1) Ms. Smita Awasthi
Students Currently Working in Grant-In-Aid Project (One):
Junior Research Fellow: (1) Ms. Nidhi Sachan
Students Completed Training for Bachelor’s/Master’s Dissertation: Twenty Five
Research Publications:
1. Mishra AK, Mishra S, Rajput C, Ur Rasheed MS, Patel DK, Singh MP* (2018). Cypermethrin
activates autophagosome formation albeit inhibits autophagy owing to poor lysosome quality:
relevance to Parkinson's disease. Neurotox. Res. 33(2):377-387.
2. Ur Rasheed MS, Mishra AK, Singh MP* (2017). Cytochrome P450 2D6 and Parkinson's
disease: polymorphism, metabolic role, risk and protection. Neurochem. Res. 42(12):3353-3361.
3. Tripathi P, Singh A, Bala L, Patel DK, Singh MP* (2017). Ibuprofen protects from
cypermethrin-induced changes in the striatal dendritic length and spine density. Mol. Neurobiol.
DOI: 10.1007/s12035-017-0491-9.
4. Ur Rasheed MS, Tripathi S, Mishra S, Singh MP* (2017). Coherent and contradictory facts,
feats and fictions associated with metal accumulation in Parkinson's disease: epicenter or
outcome, yet a Demigod question. Mol. Neurobiol. 54(6):4738-4755.
5. Singh A, Tripathi P, Prakash O, Singh MP* (2016). Ibuprofen abates cypermethrin-induced
expression of pro-inflammatory mediators and mitogen-activated protein kinases and averts the
nigrostriatal dopaminergic neurodegeneration. Mol. Neurobiol. 53(10):6849-6858.
6. Tan EK, Srivastava AK, Arnold WD, Singh MP, Zhang Y (2016). Neurodegeneration:
etiologies and new therapies 2016. Biomed. Res. Int. 2016:8363179.
7. Gupta SP, Kamal R, Mishra SK, Singh MK, Shukla R, Singh MP* (2016). Association of
polymorphism of neuronal nitric oxide synthase gene with risk to Parkinson's disease. Mol
Neurobiol. 53(5):3309-3314.
8. Ur Rasheed MS, Tripathi MK, Mishra AK, Shukla S, Singh MP* (2015). Resveratrol protects
from toxin-induced Parkinsonism: plethora of proofs hitherto petty translational value. Mol.
Neurobiol. 53(5):2751-2760.
9. Agrawal S, Dixit A, Singh A, Tripathi P, Singh D, Patel DK, Singh MP* (2015). Cyclosporine
A and MnTMPyP alleviate α-synuclein expression and aggregation in cypermethrin-induced
Parkinsonism. Mol Neurobiol. 52(3):1619-1628.
10. Singhal NK, Agarwal S, Bhatnagar P, Tiwari MN, Tiwari SK, Srivastava G, Kumar P, Seth B,
Patel DK, Chaturvedi RK, Singh MP*, Gupta KC (2015). Mechanism of nanotization-mediated
improvement in the efficacy of caffeine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-
induced Parkinsonism. J. Biomed. Nanotechnol. 11: 2211-2222.
11. Tan EK, Srivastava AK, Arnold WD, Singh MP, Zhang Y (2015). Neurodegeneration:
etiologies and new therapies. Biomed Res Int. 2015:272630.
12. Mishra AK, Rasheed MS, Shukla S, Tripathi MK, Dixit A, Singh MP* (2015). Aberrant
autophagy and Parkinsonism: Does correction rescue from disease progression? Mol. Neurobiol.
51(3):893-908.
13. Agrawal S, Singh A, Tripathi P, Mishra M, Singh PK, Singh MP* (2015). Cypermethrin-
induced nigrostriatal dopaminergic neurodegeneration alters the mitochondrial function: a
proteomics study. Mol. Neurobiol. 51(2):448-465.
14. Tripathi P, Singh A, Agrawal S, Prakash O, Singh MP* (2014). Cypermethrin alters the status of
oxidative stress in the peripheral blood: relevance to Parkinsonism. J. Physiol. Biochem.
70(4):915-924.
15. Gupta SP, Yadav S, Singhal NK, Tiwari MN, Mishra SK, Singh MP* (2014). Does restraining
nitric oxide biosynthesis rescue from toxins-induced Parkinsonism and sporadic Parkinson's
disease? Mol. Neurobiol. 49(1):262-275.
16. Tiwari MN, Agarwal S, Bhatnagar P, Singhal NK, Tiwari SK, Kumar P, Chauhan LK, Patel
DK, Chaturvedi RK, Singh MP*, Gupta KC (2013). Nicotine-encapsulated poly(lactic-co-
glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced
Parkinsonism. Free Radic. Biol. Med. 65:704-718.
17. Singhal NK, Chauhan AK, Jain SK, Shanker R, Singh C, Singh MP* (2013). Silymarin- and
melatonin-mediated changes in the expression of selected genes in pesticides-induced
Parkinsonism. Mol. Cell. Biochem. 384(1-2):47-58.
18. Dixit A, Srivastava G, Verma D, Mishra M, Singh PK, Prakash O, Singh MP* (2013).
Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of
MPTP and maneb and paraquat mice models of Parkinson's disease. Biochim. Biophys. Acta:
Mol. Basis Dis. 1832(8):1227-1240.
19. Yadav S, Dixit A, Agrawal S, Singh A, Srivastava G, Singh AK, Srivastava PK, Prakash O,
Singh MP* (2012). Rodent models and contemporary molecular techniques: notable feats yet
incomplete explanations of Parkinson's disease pathogenesis. Mol. Neurobiol. 46(2):495-512.
20. Tiwari MN, Singh AK, Agrawal S, Gupta SP, Jyoti A, Shanker R, Prakash O, Singh MP*
(2012). Cypermethrin alters the expression profile of mRNAs in the adult rat striatum: a putative
mechanism of postnatal pre-exposure followed by adulthood re-exposure-enhanced
neurodegeneration. Neurotox. Res. 22(4):321-334.
21. Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP* (2012). Resveratrol
potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced
Parkinsonism in the mouse. Free Radic. Biol. Med. 52(8):1294-1306.
22. Yadav S, Gupta SP, Srivastava G, Srivastava PK, Singh MP* (2012). Role of secondary
mediators in caffeine-mediated neuroprotection in maneb- and paraquat-induced Parkinson's
disease phenotype in the mouse. Neurochem. Res. 37(4):875-884.
23. Singhal NK, Srivastava G, Agrawal S, Jain SK, Singh MP* (2012). Melatonin as a
neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable
clinical translation? Mol. Neurobiol. 45(1):186-199.
24. Singh AK, Tiwari MN, Upadhyay G, Patel DK, Singh D, Prakash O, Singh MP* (2012). Long
term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult
rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiol. Aging
33(2):404-415.
25. Singh AK, Tiwari MN, Prakash O, Singh MP* (2012). A current review of cypermethrin-
induced neurotoxicity and nigrostriatal dopaminergic neurodegeneration. Curr. Neuropharmacol.
10(1):64-71.
26. Srivastava G, Dixit A, Prakash O, Singh MP* (2011). Tiny non-coding RNAs in Parkinson's
disease: implications, expectations and hypes. Neurochem. Int. 59(6):759-769.
27. Singh AK, Tiwari MN, Dixit A, Upadhyay G, Patel DK, Singh D, Prakash O, Singh MP*
(2011). Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration:
microglial activation-dependent and -independent regulations. Toxicol. Sci. 122(2):526-538.
28. Singhal NK, Srivastava G, Patel DK, Jain SK, Singh MP* (2011). Melatonin or silymarin
reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. J. Pineal Res.
50(2):97-109.
29. Lal K, Mani U, Pandey R, Singh N, Singh AK, Patel DK, Singh MP, Murthy RC (2011).
Multiple approaches to evaluate the toxicity of the biomass fuel cow dung (kanda) smoke.
Ecotoxicol. Environ. Saf. 74(7):2126-2132.
30. Singh V, Upadhyay G, Rastogi N, Singh K, Singh MP* (2011). Polymorphism of xenobiotic-
metabolizing genes and breast cancer susceptibility in North Indian women. Genet. Test. Mol.
Biomarkers 15(5):343-349.
31. Tiwari MN, Singh AK, Ahmad I, Upadhyay G, Singh D, Patel DK, Singh C, Prakash O, Singh
MP* (2010). Effects of cypermethrin on monoamine transporters, xenobiotic metabolizing
enzymes and lipid peroxidation in the rat nigrostriatal system. Free Radic. Res. 44(12):1416-
1424.
32. Gupta SP, Patel S, Yadav S, Singh AK, Singh S, Singh MP* (2010). Involvement of nitric oxide
in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: Is there any link with
lipid peroxidation? Neurochem. Res. 35(8):1206-1213.
33. Upadhyay G, Tiwari MN, Prakash O, Jyoti A, Shanker R, Singh MP* (2010). Involvement of
multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated
protection: evidence from gene expression profiles. Food Chem. Toxicol. 48(6):1660-1670.
34. Singh K, Singh S, Singhal NK, Sharma A, Parmar D, Singh MP* (2010). Nicotine- and
caffeine-mediated changes in gene expression patterns of MPTP-lesioned mouse striatum:
Implications in neuroprotection mechanism. Chem. Biol. Interact. 185(2):81-93.
35. Kumar A, Singh AK, Gautam AK, Chandra D, Singh D, Changkija B, Singh MP, Trivedi R
(2010). Identification of kaempferol-regulated proteins in rat calvarial osteoblasts during
mineralization by proteomics. Proteomics 10(9):1730-1739.
36. Singh S, Singhal NK, Srivastava G, Singh MP* (2010). Omics in mechanistic and predictive
toxicology. Toxicol. Mech. Methods 20(7):355-362.
37. Upadhyay G, Gupta SP, Prakash O, Singh MP* (2010). Pyrogallol-mediated toxicity and natural
antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations.
Chem. Biol. Interact. 183(3):333-340.
38. Srivastava G, Singh K, Tiwari MN, Singh MP* (2010). Proteomics in Parkinson's disease:
current trends, translational snags and future possibilities. Expert Rev. Proteomics 7(1):127-139.
39. Yadav S, Singhal NK, Singh V, Rastogi N, Srivastava PK, Singh MP* (2009). Association of
single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility
in Indian women. Dis. Markers 27(5):203-210.
40. Dangi A, Vedi S, Nag JK, Paithankar S, Singh MP, Kar SK, Dube A, Misra-Bhattacharya S
(2009). Tetracycline treatment targeting Wolbachia affects expression of an array of proteins in
Brugia malayi parasite. Proteomics 9(17):4192-4208.
41. Singh S, Singh K, Patel DK, Singh C, Nath C, Singh VK, Singh RK, Singh MP* (2009). The
expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation
in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and
nicotine-mediated neuroprotection. Rejuvenation Res. 12(3):185-197.
42. Singh S, Singh K, Gupta SP, Patel DK, Singh VK, Singh RK, Singh MP* (2009). Effect of
caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine
transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum.
Brain Res. 1283:115-126.
43. Sinha A, Srivastava N, Singh S, Singh AK, Bhushan S, Shukla R, Singh MP* (2009).
Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease
patients: a proteomic approach. Clin. Chim. Acta 400(1-2):14-20.
44. Swarnkar S, Tyagi E, Agrawal R, Singh MP, Nath C (2009). A comparative study on oxidative
stress induced by LPS and rotenone in homogenates of rat brain regions. Environ. Toxicol.
Pharmacol. 27(2):219-224.
45. Upadhyay G, Singh AK, Kumar A, Prakash O, Singh MP* (2008). Resveratrol modulates
pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and
oxidative stress. Eur. J. Pharmacol. 596(1-3):146-152.
46. Patel S, Singh K, Singh S, Singh MP* (2008). Gene expression profiles of mouse striatum in
control and maneb + paraquat-induced Parkinson's disease phenotype: validation of differentially
expressed energy metabolizing transcripts. Mol. Biotechnol. 40(1):59-68.
47. Singh V, Parmar D, Singh MP* (2008). Do single nucleotide polymorphisms in xenobiotic
metabolizing genes determine breast cancer susceptibility and treatment outcomes? Cancer
Invest. 26(8):769-783.
48. Singh S, Singh K, Patel S, Patel DK, Singh C, Nath C, Singh MP* (2008). Nicotine and
caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular
monoamine transporter-2 in 1-methyl 4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinson's
disease phenotype in mouse. Brain Res. 1207:193-206.
49. Singh V, Rastogi N, Mathur N, Singh K, Singh MP* (2008). Association of polymorphism in
MDM-2 and p53 genes with breast cancer risk in Indian women. Ann. Epidemiol. 18(1):48-57.
50. Kumar A, Upadhyay G, Modi DR, Singh MP* (2007). The involvement of secondary signaling
molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in
benzo(a)pyrene-treated rat polymorphonuclear leukocytes. Life Sci. 81(23-24):1575-1584.
51. Patel S, Sinha A, Singh MP* (2007). Identification of differentially expressed proteins in
striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse. Neurotoxicol.
Teratol. 29(5):578-585.
52. Upadhyay G, Kumar A, Singh MP* (2007). Effect of silymarin on pyrogallol- and rifampicin-
induced hepatotoxicity in mouse. Eur. J. Pharmacol. 565(1-3):190-201.
53. Sinha A, Patel S, Shukla R, Singh MP* (2007). Blood proteome profiling in case controls and
Parkinson's disease patients in Indian population. Clin. Chim. Acta 380(1-2):232-234.
54. Sinha A, Singh C, Parmar D, Singh MP* (2007). Proteomics in clinical interventions:
achievements and limitations in biomarker development. Life Sci. 80(15):1345-1354.
55. Singh V, Rastogi N, Sinha A, Kumar A, Mathur N, Singh MP* (2007). A study on the
association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian
women. Breast Cancer Res. Treat. 101(1):73-81.
56. Singh MP*, Patel S, Dikshit M, Gupta YK (2006). Contribution of genomics and proteomics in
understanding the role of modifying factors in Parkinson's disease. Indian J. Biochem. Biophys.
43(2):69-81.
57. Kumar A, Patel S, Gupta YK, Singh MP* (2006). Involvement of endogenous nitric oxide in
myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury. Mol.
Cell. Biochem. 286(1-2):43-51.
58. Patel S, Singh V, Kumar A, Gupta YK, Singh MP* (2006). Status of antioxidant defense system
and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced
Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res.
1081(1):9-18.
59. Saini R, Patel S, Saluja R, Sahasrabuddhe AA, Singh MP, Habib S, Bajpai VK, Dikshit M
(2006). Nitric oxide synthase localization in the rat neutrophils: immunocytochemical,
molecular, and biochemical studies. J. Leukoc. Biol. 79(3):519-528.
60. Patel S, Parmar D, Gupta YK, Singh MP* (2005). Contribution of genomics, proteomics, and
single-nucleotide polymorphism in toxicology research and Indian scenario. Indian J. Hum.
Genet. 11(2):61-75.
61. Patel S, Sinha A, Parmar D, Singh MP* (2004). An update on the role of environmental factors
in Parkinson's disease. Ann. Neurosci. 12(4):79-86.
62. Singh MP, Sinha S, Raghavan SA, Dikshit M (2002). Inhibition of platelet aggregation by rat
globin. Thromb. Res. 107(5):201-207.
63. Tewari R, Singh MP, Farheen S, Dikshit M, Mehrotra PK (2002). Inhibition of platelet
aggregation by rat trophoblasts. Med. Princ. Pract. 11(2):100-104.
64. Saxena AK, Pandey SK, Seth P, Singh MP, Dikshit M, Carpy A (2001). Synthesis and QSAR
studies in 2-(N-aryl-N-aroyl)amino-4,5-dihydrothiazole derivatives as potential antithrombotic
agents. Bioorg. Med. Chem. 9(8):2025-2034.
65. Sethi S, Singh MP, Dikshit M (2000). Mechanisms involved in the augmentation of arachidonic
acid-induced free-radical generation from rat neutrophils following hypoxia-reoxygenation.
Thromb. Res. 98(5):445-450.
66. Sethi S, Singh MP, Dikshit M (1999). Nitric oxide-mediated augmentation of
polymorphonuclear free radical generation after hypoxia-reoxygenation. Blood 93(1):333-340.
67. Kumari R, Singh MP, Seth P, Dikshit M (1998). Inhibition of platelet aggregation by a protein
factor present in rat peripheral polymorphonuclear leukocyte supernatant. Thromb. Res.
91(2):75-82.
68. Tandon R, Singh MP, Haq W, Dikshit M, Patnaik GK, Dhar MM (1997). Synthesis of novel
tetra-peptides as potential ACE inhibitors. Indian J. Chemistry 36(B):386-390.*Corresponding author
Abstracts Published in National/International Journals:
1. Ur Rasheed MS, Singh MP (2017). Resveratrol restores CYP2D6 enzyme activity and
upregulates Nrf2-Keap1 pathway in maneb- and paraquat- treated SH-SY5Y cell line. J.
Neurochem. 142; Suppl. 1 (abstract no.: MTU04-13):110.
2. Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP (2013). Nicotine neuroprotects
against maneb- and paraquat-induced Parkinson’s disease phenotype in mouse by augmenting
cytochrome P450 2d22 expression. Mov. Disord. 28; Suppl. 1 (abstract no.:577): S204-S205.
3. Dixit A, Srivastava G, Verma D, Mishra M, Singh PK, Prakash O, Singh MP (2013). Effect of
minocycline, levodopa and MnTMPyP on maneb- and paraquat-induced Parkinson’s disease
phenotype: Role of mitochondria. Mov. Disord. 28; Suppl. 1 (abstract no.: 578): S205-S206.
4. Dikshit M, Seth S, Singh MP (1998). Involvement of nitric oxide in the hypoxia-reoxygenation
mediated augmentation of polymorphonuclear free radical generation. Nitric Oxide: Biol. Chem.
2(2): F9.
5. Singh MP, Seth S, Dikshit M (1997). Alteration in free radical generation and nitric oxide
release from rat peripheral polymorphonuclear leukocytes following hypoxia-reoxygenation.
Indian J. Pharmacol. 29 (1); (abstract no.: 35): 31.
6. Sethi S, Singh MP, Dikshit M (1997). Effect of cyclic AMP and calmodulin antagonists on the
free radical generation from rat polymorphonuclear leukocytes following hypoxia and
reoxygenation. Indian J. Pharmacol. 29 (1); (abstract no. 34): 31.
Abstracts Presented in the National/International Conferences:
Fifty one (excluding invited lectures)
Invited Lectures in the Conferences/Symposia:
1. “Genomic approaches for predicting chemical exposure” at the All India Institute of Medical
Sciences (AIIMS), New Delhi, India during the “Symposium on Awareness Preparedness and
Mitigation off Exposure to Domestic and Industrial Chemicals” on August 30-31, 2007
2. “Genomics and proteomics in Parkinson’s disease research” at the AIIMS, New Delhi, India
during the “International Conference on Translational Pharmacology and 41st Annual Meeting of
Indian Pharmacological Society” on December 18-20, 2008
3. “Parkinson’s disease: development of peripheral biomarkers and insights of the molecular
mechanisms” at the Biochemistry Department, University of Allahabad, Allahabad, India during
the “National Conference on Emerging Trends in Biochemistry-2010” on January 23-24, 2010
4. “Pyrogallol-induced hepatotoxicity and naturally occurring antioxidants” at the Biochemistry
Department, BHU, Varanasi, India during the “International Conference on Role of Bio-
molecules in Food Security and Health Improvement (ICBFH), 2010” on February 17-20, 2010
5. “Cypermethrin and nigrostriatal dopaminergic neurodegeneration” at the CSIR-Indian Institute
of Toxicology Research, Lucknow, India during the “XXXII Annual Meeting of Society of
Toxicology (STOX) and International Symposium on New Paradigms in Toxicology” on
December 5-7, 2012
6. “Free radicals and pesticides-induced Parkinson’s disease” at the CSIR-Indian Institute of
Toxicology Research, Lucknow, India during the “International Conference on Advances in Free
Radicals, Redox Signaling and Translational Antioxidant Research and XII Annual Meeting of
the Society for Free Radical Research, India” on January 30-February 1, 2013
7. “Cypermethrin-induced neurodegeneration: An environmentally relevant model of Parkinson’s
disease” at the Environmental Science Department of BBA University, Lucknow, India during
the “1st Lucknow Science Congress” on March 20-21, 2013
8. “Resveratrol augments cytochrome P4502d22-mediated protection against maneb- and paraquat-
induced Parkinsonism” at the Biochemistry Department, Faculty of Science, Aligarh Muslim
University, Aligarh, India during the “National symposium on Advances in Free Radical Biology
and Biochemistry" on March 6, 2014
9. “Relevance of animal models in PD research” at the CSIR-Central Drug Research Institute,
Lucknow during the “National Symposium on Animals in Research and Testing: A Cross Talk
between Relevance and Ethics (NSART 2015)” on March 13-14, 2015
10. Naturally occurring antioxidants and Parkinsonism: Can Ayurveda everlastingly treat
Parkinson’s disease?” at the Banaras Hindu University, Varanasi, India during an international
conference on the “Role of Basic Sciences in Translational Research in Ayurvedic Medicine” on
October 28, 2017
11. “Cypermethrin-induced Parkinsonism: how close is it to an ideal model for Parkinson’s
disease?” at the Central Drug Research Institute, Lucknow, India during the “Symposium on
Molecular Medicines for Lifestyle Diseases: Emerging Targets and Approaches” on November
20-21, 2017
Scientific Session Chaired:
Scientific session on “Bio-molecules in amelioration of clinical disorders” at the Biochemistry
Department, BHU, Varanasi, India during the “International Conference on the Role of Bio-
molecules in Food Security and Health Improvement (ICBFH), 2010” on February 17-20, 2010
Special Guest of Honor:
An international conference on the “Role of Basic Sciences in Translational Research in
Ayurvedic Medicine” held at the Banaras Hindu University, Varanasi, India on October 28, 2017
Conference Organized:
1. Convener, International Toxicology Conclave-2017 held at CSIR-Indian Institute of Toxicology
Research, Lucknow, India on November 5-6, 2017
2. Joint Organizing Secretary, International Symposium on New Frontiers in Toxicology and
XXXII Annual Meeting of Society of Toxicology (STOX), India held at CSIR-Indian Institute of
Toxicology Research, Lucknow, India on December 5-7, 2012
3. Joint Organizing Secretary, International Symposium on Diet in Causation & Prevention of
Cancer and XXX Annual Conference of Environmental Mutagen Society of India held at CSIR-
Indian Institute of Toxicology Research, Lucknow, India on March 17-19, 2005
