James Richard Goldenring MD, PhD · 2019-08-06 · Final position: Professor and Chief of Surgery, University of Rejkavik, Iceland. Deceased 2009 Masato Funasaka, MD 1990-1991 Present

GOLDENRING: Page 1

CURRICULUM VITAE

James Richard Goldenring MD, PhD

ADDRESS: Department of Surgery

Vanderbilt University School of Medicine

10435G MRB IV

2213 Garland Avenue

Nashville, TN 37232

TEL: (615) 936-3726

FAX: (615) 343-1591

EMAIL: [email protected]

PERSONAL: Date of Birth: December 24, 1958, New Haven, CT.

Children: Jessica (24 yo) and Kate (22 yo)

Married: Barbara M. Fingleton, PhD

EDUCATION: M.D. May 1986

Yale University School of Medicine

PhD. December 1984

Yale University

Molecular Biophysics and Biochemistry

Dissertation: Purification, characterization and distribution of a calmodulin-

dependent kinase from rat brain.

Advisor: Robert J. DeLorenzo, MD, PhD

M.Phil. May 1984

Yale University

Molecular Biophysics and Biochemistry

A.B. June 1980

Magna Cum Laude

Harvard University

Biochemical Sciences

Thesis: The effects of artificial food dyes on the developing nervous system:

Tartrazine and sunset yellow.

GOLDENRING: Page 2

Advisors: Bennett A. Shaywitz, MD and Ronald Harris-Warwick, PhD

EXPERIENCE: Scientific Director 2013-present

Translational Pathology Shared Resource

Digital Histology Shared Resource


Co-Director 2008-present

Epithelial Biology Center


Professor and Vice Chairman for Surgical Research 2002-present

Paul W. Sanger Chair in Surgical Investigation


Professor of Cell and Developmental Biology 2002-present


Staff Physician 2002-present

Nashville VA Medical Center

Chief, Program in Cell Signaling 1998-2002

Institute of Molecular Medicine and Genetics

Medical College of Georgia

Professor of Medicine, Surgery and Cellular Biology 1998-2002


Associate Professor of Cellular Biology and Anatomy 1994-1998


Director Georgia University System MD/PhD Program 1994-2002


Associate Professor of Medicine and Surgery 1993-1998

Institute of Molecular Medicine and Genetics


Staff Physician 1993-2002

Augusta VA Medical Center

Director, Laboratory of Molecular Gastroenterology 1993-2002

Augusta VA Medical Center

GOLDENRING: Page 3

Assistant Professor of Surgery 1990-1993

Department of Surgery


Assistant Professor 1993

Cellular and Molecular Physiology


Director 1989-1993

GI Surgical Research Laboratories

West Haven VA Medical Center

Postdoctoral Fellow 1988-1990



Resident (General Surgery) 1986-1988



Postdoctoral Associate 1985-1986

Surgical Service

West Haven VA Medical Center

HONORS: AGA Institute Council Cellular and Molecular Gastroenterology Research

Mentor Award, 2016

American Association for the Advancement of Science Fellow, 2014

Association of American Physicians, 2013

Takeda Distinguished Research Award, Amer. Physiol. Society, 2011

American Gastroenterological Association Fellow, 2006

American Society for Clinical Investigation, 2004

AGA Funderburg Research Scholar in Gastric Biology Related to Cancer,

2004

Distinguished Faculty Award for Basic Science Research, MCG, 2001

Outstanding Faculty Award, School of Graduate Studies, MCG, 1998

AGA/Abbott Industry Scholar Award 1990-1993

American College of Surgeons Scholarship 1988-1990

NIH NRSA Postdoctoral Fellowship 1988-1990

Sigma Xi 1988

Lange Book Prize 1986

Alpha Omega Alpha 1986

NIH Medical Scientist Training Program Fellowship 1980-1986

Harvard College Scholar 1977-1980

Kate and Max Greenman Medal (Oratory) 1979

GOLDENRING: Page 4

Kalombodavich Award; George Breed Medal;

Captain, Harvard Fencing 1980

SOCIETIES: American Society for Clinical Investigation

American Gastroenterological Association

American Association Cancer Research

American Society for Cell Biology

Association for Academic Surgery

Society for Surgeons of the Alimentary Tract

Gastroenterology Research Group

American Association for the Advancement of Science

American Society for Biochemistry and Molecular Biology

CERTIFICATION: National Board of Medical Examiners, No. 297811

Connecticut State Medical License, No. 029226

Georgia State Medical License, No. 37547

GOLDENRING: Page 5

ADMINSTRATIVE POSITIONS HELD:

Charles Ohse Research Fund Committee, Yale Department of Surgery 1988-1993

Medical Student Thesis Committee, Yale Department of Surgery 1990-1993

West Haven VAMC Scientific Projects Committee 1990-1993

West Haven VAMC Research and Development Committee 1991-1993

Steering Committee, Amer. Physiol. Soc. Parietal Cell Club. 1991-1993

Chairman, Amer. Physiol. Soc. Parietal Cell Club. 1993

MD/PhD Admissions Committee, Yale Medical School 1992-1993

Medical Student Thesis Awards Committee, Yale Medical School 1992-1993

Augusta VAMC Scientific Projects Committee 1993-2002

Augusta VAMC Research and Development Committee 1993-96, 97-00, 02

Chairman, Augusta VAMC Research and Development Committee 1994-1996

Nashville VAMC Research and Development Committee 2004-2007

Vice-Chairman, Nashville VAMC Research and Development Comm. 2005-2007

Nashville VAMC Safety Committee, Vice Chairman 2007-2012

Nashville VAMC Safety Committee 2014-present

MCGRI Grants Review Committee 1993-1996

Biosafety Committee, Medical College of Georgia 1993-1996

MD/PhD Advisory Committee, Medical College of Georgia 1993-2002

Director, Georgia University System MD/PhD Program 1994-2002

Anatomy and Cellular Biology Graduate Student Committee, MCG 1994-1997

Institute of Molec. Medicine and Genetics Exec. Council, MCG 1998-2002

Chief, Program in Cell Signaling, IMMAG, MCG 1998-2002

Cell and Devel. Biology Graduate Student Committee, Vanderbilt 2003-present

Research Enterprise Committee, Vanderbilt 2003-2012

Vanderbilt MD/PhD Committee 2005-2014

Vanderbilt MSTP College Advisor 2017-

Vanderbilt VPSD Oversight Committee 2004-2010

Vanderbilt IACUC 2006-2008

Program Director, Vanderbilt DDRC 2012-

Director, DDRC Enteroid Core Resource 2016-

AGA Abstract Review Committees 1994-2017

AGA Councilor, Intestinal Disorders Section 2005-2009

AGA Councilor, Hormones and Receptors Section 2006-present

Vice Chairman, AGA Hormones and Receptors Section 2009-2011

Chairman, AGA Hormones and Receptors Section 2011-2013

AGA Research Committee 2006-2009

Advisory Board Member, Johns Hopkins Digestive Disease Center 2003-present

External Advisory Board: UAB/UMinn SPORE in Pancreas Cancer 2011-2015

Steering Committee, Gastrointestinal Research Group 2004-2006

Steering Committee, Amer. Physiol. Soc. Parietal Cell Club. 2003-2006

GOLDENRING: Page 6

Executive Committee, International Carcinogenesis Society 2007-2015

External Advisory Board, Singapore Gastric Cancer Consortium 2014-present

International Scientific Comm., International Gastric Cancer Congress 2010-2016

Ad Hoc Member, NIH Clinical Sciences I Study Section 1991,1993

NIDDK Ad Hoc Review Committee, SRC-7 1995

NIH Special Study Section ZRG4 GRM(02)M 1998

NIH General Medicine A-2 Study Section (Ad Hoc) 1999, 2002, 2003

NIH General Medicine B Study Section (Ad Hoc) 2000

NIH Surgery and Bioengineering Study Section (Ad Hoc) 2004

NIH DDK-C Study Section (Ad Hoc) 2005,2006

NIH GCMB Study Section (Ad Hoc) 2006

NIH GCMB Study Section, Permanent Member 2007-2009

NIH CIMG Study Section, Permanent Member 2009-2011

VA Gastroenterology (GAST) Study Section 2011-2014, 2016-2018

Editorial Board, Scientific Reports 2015-2017

Editorial Board, Cellular Logistics 2010-2017

Editorial Board, Digestive Disease and Sciences 1995-2014

Editorial Board, American Journal of Physiology, GI 2003-2009

Editorial Board, Physiological Genomics 2006-2012

Editorial Board, Gastroenterology 2010-2014

Associate Editor, American Journal of Physiology, GI 2006-2009

Assoc. Editor, Cellular and Molecular Gastroenterology and Hepatology 2014-2019

GOLDENRING: Page 7

TRAINEES:

Previous trainees:

Postdoctoral Fellows:

Margret Oddsdottir, MD 1988-1989

Final position: Professor and Chief of Surgery, University of Rejkavik, Iceland.

Deceased 2009

Masato Funasaka, MD 1990-1991

Present position: Assistant Professor of Surgery, Kobe University

Yasuhiro Tsunoda, PhD 1990-1992

Deceased.

Laura H. Tang, MD,PhD 1990-1993

NIH NRSA Postdoctoral Fellowship

Present position: Associate Professor of Pathology, Memorial Sloan Kettering

Daniel T. Dransfield, PhD 1993-1996

NIH NRSA Postdoctoral Fellowship

Present position: Senior Vice President, Research & Development, Siamab

Therapeutics, Inc.

Patricia Cameron, PhD 1994-1995

Present position: Vice Dean Graduate Studies, Medical College of Georgia

Gregory S. Ray, MD 1995-1996

Present position: Pathologist, Atlanta, Georgia

Virendra Joshi, MD 1995-1996

Present position: Director, Endoscopy and Hepatobiliary Services, Tulane University

Hospital and Clinic

Sheela Bhartur, PhD 1996-1999

Present position: Assistant Professor of Nuclear Medicine, Univ. North Carolina

Kingsley Nwokeji, MD 1996-1998

NIH Minority Postdoctoral Fellow

Present position: Psychiatrist, Bronx-Lebanon Hospital

Lynne Lapierre, PhD 1997-1999

Present position: Research Assistant Professor, Vanderbilt

Ravin Kumar, PhD 1997-2000

Present position: Research Associate, Morehouse School of Medicine

Richard Griner, PhD 1999-2001

Present position: Professor and Chairman of Biology, Augusta State University

Hirokazu Yamaguchi, MD 2000-2002

Present position: Associate Professor of Surgery, University of Tokyo, Japan

Karen Hobdy-Henderson, DPharm. 2002-2004

NIH Minority Investigator Fellowship

Present Position: Practicing Pharmacist

Cecilia Larocca, PhD 2001-2004

Present position: Assistant Professor of Physiology, University of Rosario, Argentina

Sachiyo Nomura, MD, PhD 2002-2005

Present Position: Associate Professor of Gastrointestinal Surgery, University of Tokyo

Charles Leys, MD, MSCI 2003-2005

GOLDENRING: Page 8

Present Position: Associate Professor of Surgery, University of Wisconsin

Masako Ogawa, MD 2004-2006

Present Position: Assistant Professor in Gastrointestinal Surgery, University of Tokyo

Min Jin, MD, PhD 2003-2006

Present Position: Oncologist, Salinas Valley Memorial Hospital, Washington.

Koji Nozaki, MD, PhD, AGA J. Isenberg International Research Fellow, 2006-2008

Present Position: Assistant Professor of Gastrointestinal Surgery, University of Tokyo

Hyuk-Joon Lee, MD 2007-2009

Present position: Professor of Surgery, Division Chief, Gastrointestinal Surgery

Seoul National University

Joseph Roland, PhD, Kirchstein Individual F32 NIH NRSA Fellow 2006-2009

Present Position: Research Assistant Professor in Surgery, Managing Director, Digital

Histology Shared Resource, VUMC

Elena Kolobova, PhD 2006-2009

Present Position: Research Assistant Professor of Surgery, Vanderbilt University

Ki Taek Nam, DVM, PhD 2006-2009

Present Position: Associate Professor of Veterinary Medicine, Yonsei Med. Ctr, Korea

Janice Williams, PhD 2007-2011, IBSTO T32 NRSA Postdoctoral Fellow 2009-2011

Present Position: Director, Electron Microscopy Facility, Vanderbilt University

Moorthy Krishnan, PhD 2009-2012

Present Position: Assistant Project Scientist, Univ. California, Riverside

Nick Baetz, PhD 2009-2013

Present Position: Director of Cell and Tissue Biology in Research and Development,

Polarity TE

Jenny Schafer, PhD; 2009-2014; Kirchstein Individual F32 NIH NRSA Fellow, 2009-2011

Present Position: Managing Director, Cell Imaging Shared Resource, Vanderbilt

Josane Freitas-Sousa, PhD 2011-2015; Prevent Cancer Foundation Fellow

Present Position: Assistant Professor, Univ. Sao Paolo, Brazil

Eunyoung Choi, PhD 2012-2015

Present Position: Assistant Professor of Surgery, Vanderbilt

Victoria Weis, PhD 2014-2016

NIH T32 NRSA Postdoctoral Fellow

Present position: Instructor, Wake Forest University.

Cameron Schlegel, MD 2015-2017

NIH T32 NRSA Postdoctoral Fellow

Present position: Surgical Oncology Fellow, University of Pittsburgh

Takahiro Shimizu, MD, PhD 2015-2017

Japan Society Research Fellow

Present position: Assistant Professor of Gastroenterology, Kyoto University, Japan

Carolina Pinzon-Guzman, MD, PhD 2016-2018

NIH T32 Postdoctoral Fellow

Present Position: Resident in General Surgery, VUMC

GOLDENRING: Page 9

Graduate Students:

Jonathan Lewis, MD, PhD 1989-1991

Present position: CEO Samus Therapeutics

Benjamin Calhoun, MD, PhD 1994-1997

Present position: Associate Professor, Director of Breast Pathology, University of North

Carolina

P. Hank Schmidt, MD, PhD 1997-2000

NIH NRSA Postdoctoral Fellow

Present position: Associate Professor of Surgery, Mt. Sinai Medical School

Ryan Shanks, PhD 1998-2002

Present position: Professor of Biology, University of North Georgia

Brent Steadman, MD, PhD 2000-2003

Present position: Diagnostic Radiologist, Morgantown, WV.

Chad Hales, MD, PhD 2000-2003

Present position: Assistant Professor in Neurology, Emory

Nicole Ducharme, PhD 2004-2008

Present Position: Scientific Editor, Bioscience Writers, LLC

Victoria Weis, PhD 2009-2013

Present Position: Senior Postdoctoral Fellow, Wake Forest University

Twila Mason, PhD 2009-2013

CBMS Institutional T32 NRSA Fellow

Present Position: Adjunct Assistant Prof., Southeast Missouri State University

Byron Knowles, MD, PhD 2010-2014

Present position: Resident in Dermatology, Univ. California, San Francisco

Christine P. Petersen, PhD 2011-2016

F31 NRSA Fellow

Present Position: Senior Scientist, VL51, Inc.

Rebecca McRae, MS

Present Position: High School Teacher, Nashville

Medical Thesis Students:

Valerie Asher, MD 1989-1990

American Heart Association Research Award

Present position: ENT Surgeon, Bethesda, MD

William Rodriguez, MD 1991-1992

Present position: CEO, Daktari Diagnostics

K. Robert Shen, MD 1991-1992

Present position: Professor of Thoracic Surgery, Mayo Clinic

Undergraduate Students:

Sanjay Iyer 1994

American Heart Association Summer Fellowship

GOLDENRING: Page 10

Present position: Director of Carolinas Center for Parkinson Disease and Movement

Disorders, Charlotte, NC

Joseph Kurkjian 1995

AGA Summer Student Fellowship

Present position: Radiologist, Upstate Carolina Radiology

Daniel Sheehan 1994-1996

AGA Summer Student Fellowship

Present position: Rehabilitation Medicine, Hartford, CT

Jason Burnette 1999-2000

Present position: Urology Specialists of Georgia

Karen Riggins 2003-2004

IMSD Predoctoral Fellow, Vanderbilt

Present position: Graduate Student in Cell and Developmental Biology, Vanderbilt

Present Trainees:

Postdoctoral Fellows:

Amy Engevik, PhD

NIH F32 Postdoctoral Fellow

Katherine Riera, MD

NIH T32 Postdoctoral Fellow

Colleen LeBlanc, MD

Se-Hoon Hong, PhD

Graduate Students:

Anne Meyer, Graduate Student, Cell and Developmental Biology

CBMS Institutional T32 NRSA Fellow

F31 Individual NRSA Predoctoral Fellow

Yoojin Sohn, Graduate Student, Cell and Developmental Biology

GOLDENRING: Page 11

PREVIOUS FUNDING:

American College of Surgery 1988-1990

American College of Surgery Scholarship

National Institutes of Health 1988-1990

Individual NRSA Postdoctoral Fellowship

Charles Ohse Research Award 1988-1989

Characterization of a manganese-dependent protein kinase.

Charles Ohse Research Award 1989-1990

Isolation of a histamine-stimulated phosphoprotein.

BRSG Award (Yale) 1990-1991

Characterization of calmodulin-dependent protein kinase II in parietal cells

American Gastroenterology Association 1990-1993

AGA/Abbott Industry Research Scholar

VA Merit Review 1990-1993

Cytoskeletal basis of parietal cell function.

MCG Research Institute 1993-1994

Small GTP-binding proteins in gastrointestinal mucosa: Rab11 and Rab25

American Heart Association, Georgia Affiliate 1994-1996

Isolation and cDNA cloning of smooth muscle relaxation-associated phosphoproteins.

NIH FIRST Award DK 38063 1991-1997

Cyclic AMP as a mediator of parietal cell secretion.

Veterans Administration Merit Review 1994-1997

Protein kinases in parietal cell function.

NIH RO1 DK48370 1994-1998

Small GTP-binding proteins in gastrointestinal mucosa.


Parietal cells, transforming growth factor-alpha and gastric mucosal homeostasis.

NIH RO1 DK 38063 1997-2002

Cyclic AMP as a mediator of parietal cell function.

NIH RO1 DK48370 1998-2003

Small GTP-binding proteins in gastrointestinal mucosa

GOLDENRING: Page 12

NIH R21 AR49311 2002-2004

Rab25 in the Pathogenesis of Ichthyosis Vulgaris

GI SPORE Pilot Project (1P 50 CA95103) 2003-2004

Characterization of genes expressed in Spasmolytic Polypeptide Expressing Metaplasia


Oxyntic atrophy and novel gastric lineages

AGA Funderburg Research Scholar in Gastric Biology Related to Cancer 2004-2005

Characterization of genes associated with gastric metaplasia and cancer.

NIH R56 DK070856 2005-2006

Molecular characteristics of the apical recycling system.

NIH RO1-DK43405 2002-2008

Cyclic AMP as a mediator of epithelial cell function.

NIH S10 RR023901-01 2007-2008

Olympus FV1000 Confocal Fluorescence Microscope

NIH T32 CA106183 2005-2010

Surgical oncology training grant



R01 DK070856 and R01 DK070856-S1 (ARRA) 2006-2011


NIH RO1 DK43405 2009-2012

Cyclic AMP as a mediator of epithelial cell function.

NIH RO1 DK48370 2008-2012


RO1 DK071590 and RO1 DK071590-S1 (ARRA Supplemental Revision) 2008-2013

Mechanisms of Gastric Mucous Cell Metaplasia

NIH R13 DK096906 2012

Gastrointestinal Stem Cell Meeting

RO1 DK071590 2008-2013

Mechanisms of Gastric Mucous Cell Metaplasia

GOLDENRING: Page 13

DDRC Translational Pilot Grant 2011-2013

Mapping the cell lineages of the normal and obese human stomach

NIH UL1 TR000445 2012-2013

Vanderbilt Institute for Clinical and Translational Research Grant (VICTR)

MicroRNA-Based Serum Screening for Gastric Pre-Cancer

1I01BX000930 2011-2015


Veterans Administration Merit Review

R24 DK093421 2013-2015

Molecular and Cellular Basis for the Efficacy of Bariatric Surgery

Principal Investigator: Roger Cone, PhD (Co-PI: Goldenring)

1IS1BX003154 2015

Arcturus XT-TI Laser Capture Microdissection Instrument

PI (VA Shared Instrumentation Grant)

1IS1BX003097 2015

Ariol SL200 Digital Imaging System

PI (VA Shared Instrumentation Grant)

R01 DK070856 2011-2016


Principal Investigator

NIH RO1 DK48370 2012-2017


Congenital and Infantile Diarrhea 2015-2017

DDRC Translational Pilot Grant

Co-Principal Investigator (Acra)

R43 DK109820 2016-2017

Generating a Porcine Model for Human Microvillus Inclusion Disease (MVID) by Gene Editing.

Co-Principal Investigator (Melamu)

R21 CA187307 2015-2017

Mouse model of invasive colon cancer


1I01BX000930 2015-2019


Veterans Administration Merit Review

GOLDENRING: Page 14

GOLDENRING: Page 15

PRESENT FUNDING:

1) Oxyntic atrophy and novel gastric lineages

Veterans Administration Merit Review 1I01BX000930-09


Term: 10/2019-9/2023 (Pending NOGA)

2) Small GTP-binding proteins in gastrointestinal mucosa

NIH RO1 DK48370-24


Term: 8/15/2018-7/30/2021

3) Surgical oncology training grant

NIH T32 CA106183-16

Program Director

7/2015-6/2020

4) Induction and Evolution of Metaplasia in the Stomach

RO1 DK101332-06


8/1/2018-6/30/2022

5) Bile Diversion: A Simple and Effective Method of Treating Obesity

R01 DK105847

Co-Principal Investigator (Abumrad)

3/01/2015-2/28/2020

6) Identification of Metaplastic and Pre-Neoplastic Stem/Progenitor Cells

DOD CA160479


7/1/2017-6/30/2019

7) Advancing the understanding of lymphatic metastasis in gastric and colorectal cancers

DOD CA170928

Co-Principal Investigator (Fingleton)

7/1/2018-6/30/2020

8) Supporting Careers in Research for Interventional Physicians and Surgeons (SCRIPS)

Burroughs Welcome Fund Physician Scientist Institutional Award


9/1/2018-8/30/2023

9) STrOmal ReprograMing (STORMing) Provides New Directions to Prevent and Revert

Chronic Inflammation-Associated Cancers.

Cancer UK Grand Challenge

GOLDENRING: Page 16

Co-Principal Investigator (Tlsty)

1/2019-12/2024

10) Modular Automated -80C Sample Storage System

S10 OD025092


6/1/20119-5/30/2020 (NOGA pending)

11) Evaluation of effects of test articles on gastric tubulovesicles.

ViiV Healthcare


9/1/2018-8/31/2019

Pending:

1) COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository

NIH RC2 DK118640

Co-Principal Investigator

9/2019-8/2024

GOLDENRING: Page 17

PATENTS:

1. “Method of detecting and grading dysplasia in epithelial tissue” US Patent No. 6,107,048.

Issued August 22, 2000.

2. “Screen for gastric adenocarcinoma”. US Patent 6,372,439. Issued April 16, 2002.

3. “Screen for risk of gastric adenocarcinoma.” US Patent #6,773,890. Issued August 10, 2004.

4. "Method for screening for risk of gastrointestinal cancer" Patent application Ser No.

11/850,555 filed 9/5/2007.

GOLDENRING: Page 18

PUBLICATIONS:

ARTICLES

1. Shaywitz, B. A., GOLDENRING, J. R. and Wool, R. S. (1979) Effects of chronic administration of food

colorings on activity levels and cognitive performance in developing rat pups treated with 6-

hydroxydopamine. Neurobehav. Toxicol. 1:41-47.

2. GOLDENRING, J. R., Wool, R. S., Shaywitz, B. A., Batter, D. K., Cohen, D. J., Young, J. G. and Teicher,

M. H. (1980) Effects of continuous gastric infusion of food dyes on developing rat pups. Life Sciences.

27: 1897-1907.

3. GOLDENRING, J. R., Batter, D. K. and Shaywitz, B. A. (1981) Effect of chronic Erythrosin B

administration on developing rats. Neurobehav. Toxicol. Teratol. 3:57-58.

4. GOLDENRING, J. R., Batter, D. K. and Shaywitz, B. A. (1982) Sulfanilic acid: Behavioral changes

related to azo food dyes in developing rats. Neurobehav. Toxicol. Teratol. 4: 43-49.

5. GOLDENRING, J. R., Shaywitz, B. A., Wool, R. S., Batter, D. K., Anderson, G. M. and Cohen, D. J.

(1982) Environmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated

with 6-hydroxydopamine. Devel. Psychobiol. 15: 297-307.

6. GOLDENRING, J. R., Gonzalez, B. and DeLorenzo, R. J. (1982) Isolation of a brain calcium-calmodulin

tubulin kinase containing calmodulin binding proteins. Biochem. Biophys. Res. Commun. 108: 421-428.

7. GOLDENRING, J. R., Gonzalez, B., McGuire, J. S., Jr. and DeLorenzo, R. J. (1983) Purification and

characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and

microtubule associated proteins. J. Biol. Chem. 258: 12632-12640.

8. GOLDENRING, J. R., McGuire, J. S., Jr. and DeLorenzo, R. J. (1984) Identification of the major

postsynaptic density protein as homologous with the major calmodulin-binding subunit of a calmodulin-

dependent protein kinase. J. Neurochem. 42: 1077-1084.

9. GOLDENRING, J. R., Casanova, J. E. and DeLorenzo, R. J. (1984) Tubulin associated calmodulin-

dependent kinase: Evidence for an endogenous complex of tubulin with a calcium/calmodulin-dependent

kinase. J. Neurochem. 43: 1669-1679.

10. GOLDENRING, R. J., Otis, L. C., Yu, R. K. and DeLorenzo, R. J. (1985) Calcium/ganglioside-dependent

protein kinase activity in rat brain membrane. J. Neurochem. 44:1229-1234.

11. Larson, R. E., GOLDENRING, J. R., Vallano, M. L. and DeLorenzo, R. J. (1985) Identification of

endogenous calmodulin-dependent kinase and calmodulin-binding proteins in cold-stable microtubule

preparations from rat brain. J. Neurochem. 44: 1566-1574.

12. Billingsley, M. L., Velletri, P. A., Lovenberg, W., Kuhn, D., GOLDENRING, J. R. and DeLorenzo, R. J.

(1985) Is calcium-calmodulin-dependent protein phosphorylation modulated by carboxymethylation. J.

Neurochem. 44:1442-1450.

13. GOLDENRING, J. R. and DeLorenzo, R. J. (1986) Phosphorylation of MAP-2 at distinct sites by

calmodulin- and cyclic AMP-dependent kinases. Ann. N. Y. Acad. Sci. 466:457-459.

14. GOLDENRING, J. R., Vallano, M. L. and DeLorenzo, R. J. (1985) Phosphorylation of microtubule-

associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J.

Neurochem. 45:900-905.

GOLDENRING: Page 19

15. Vallano, M. L., GOLDENRING, J. R., Buckholz, T. M., Larson, R. E. and DeLorenzo, R. J. (1985)

Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc.

Natl. Acad. Sci., USA. 82:3202-3206.

16. GOLDENRING, J. R., Wasterlain, C. G., Oestreicher, A. B., de Graan. P. N. E., Farber, D. B., Glaser, G.

and DeLorenzo, R. J. (1986) Kindling induces a long lasting change in the activity of a hippocampal

membrane calmodulin-dependent protein kinase. Brain Res. 377:47-53.

17. Kim, J. Y. H., GOLDENRING, J. R., DeLorenzo, R. J. and Yu, R. K. (1986) Gangliosides inhibit

phospholipid-sensitive calcium-dependent kinase phosphorylation of rat meyelin basic proteins. J. Neurosci.

Res. 15:159-166.

18. GOLDENRING, J. R., Lasher, R. S., Vallano, M. L., Udea, T., Naito, S., Sternberger, N. H., Sternberger, L.

A. and DeLorenzo, R. J. (1986) Association of synapsin I with neuronal cytoskeleton: Identification in

cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J. Biol.

Chem. 261:8495-8504.

19. GOLDENRING, J. R., Modlin, I. M., Tyshkov, M., Zdon, M. J., Schafer, D. E., Ballantyne, G. H. (1986)

A manganese dependent protein kinase in gastric gland cytosol. Surgery. 100:181-187.

20. Sakakibara, M., Alkon, D. L., DeLorenzo, R. J., GOLDENRING, J. R., Neary, J. T. and Heldman, E.

(1986) Modulation of calcium-mediated inactivation of ionic currents by Ca2+/calmodulin-dependent

protein kinase II. Biophys. J. 50:319-327.

21. Oddsdottir, M., GOLDENRING, J. R., Tyshkov, M., Zucker, K. A., Zdon, M. J. and Modlin, I. M. (1986)

Characterization of a parietal cell cytosolic calmodulin-dependent kinase system. Surgical Forum. 37:177-

179.

22. Kreutter, D., Kim, J. Y. H., GOLDENRING, J. R., Rasmussen, H., Ukomadu, C., DeLorenzo, R. J. and Yu,

R. K. (1987) Regulation of protein kinase C by gangliosides. J. Biol. Chem. 262:1633-1637.

23. GOLDENRING, J. R., Oddsdottir, M., Modlin, I. M. (1987) A novel protein kinase activity in rabbit

gastric gland cytosol. Biochem. Biophys. Res. Commun. 142:559-566.

24. Modlin, I. M., Oddsdottir, M., Adrian, T. E., Zdon, M. J., Zucker, K. A. and GOLDENRING, J. R. A

specific histamine-stimulated phosphoprotein in isolated parietal cells. (1987) J. Surgical Res. 42:348-353.

25. Oddsdottir, M., Modlin, I. M., Zucker, K. A., Zdon, M. J. and GOLDENRING, J. R. (1987) A calmodulin-

dependent kinase in isolated parietal cells. Biochem. Biophys. Res. Commun. 148:1390-1397.

26. Oddsdottir, M., GOLDENRING, J. R., Adrian, T. E., Zdon, M. J., Zucker, K. A. and Modlin, I. M. (1988)

Identification and characterization of a cytosolic 30 kDa histamine stimulated phosphoprotein in parietal cell

cytosol. Biochem. Biophys. Res. Commun. 154:489-496.

27. GOLDENRING, J. R. and Cahow, C. E. Intrahepatic cholangiojejunostomy as a palliative procedure in

primary sclerosing cholangitis. (1989) Archives of Surgery. 124:565-567.

28. Adrian, T. E., GOLDENRING, J. R., Oddsdottir, M., Zdon, M. J., Zucker, K. A., Lewis, J. J., Modlin, I. M.

(1989) A micromethod for the assay of cellular secretory physiology: Application to rabbit parietal cells.

Anal. Biochem. 182:346-352.

29. Lewis, J. J., GOLDENRING, J. R., Asher, V. A. and Modlin, I. M. (1989) Pancreastatin: A novel peptide

inhibitor of parietal cell signal transduction. Biochem. Biophys. Res. Commun. 163: 667-673.

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30. Lewis, J. J., GOLDENRING, J. R., Asher, V. A. and Modlin, I. M. (1990) The effects of epidermal growth

factor (EGF) on signal transduction in the rabbit parietal cell. Amer. J. Physiol. 258:G476-483.

31. Lewis, J. J., GOLDENRING, J. R., Modlin, I. M. and Coffey, R. J., Jr. (1990) Inhibition of parietal cell H+

secretion by transforming growth factor-alpha: A possible autocrine regulatory mechanism. Surgery.

189:220-227.

32. Flint, J. S., Ballantyne, G. H., GOLDENRING, J. R., Fielding, L. P. and Modlin, I. M. (1990)

Neuropeptide Y inhibition of VIP stimulated ion transport in the rabbit distal colon. Archives of Surgery.

125: 1561-1563.

34. Basson, M. D., GOLDENRING, J. R., Tang, L. H., Lewis, J. J., Padfield, P., Jamieson, J. J. and Modlin, I.

M. (1991) Movement of a 23 kDa tubulovesicle-associated GTP-binding protein during parietal cell

stimulation. Biochem. J. 279: 43-48.

35. Nilsson, O., Bilchik, A. J., GOLDENRING, J. R., Ballantyne, G. H., Adrian, T. E. and Modlin, I. M.

(1991) Distribution and immunocytchemical colocalization of peptide YY and enteroglucagon in endocrine

cells of the rabbit colon. Endocrinology. 129: 139-148.

36. Tsunoda, Y. T., Funasaka, M., Modlin, I. M., Hidaka, H., Fox, L. M. and GOLDENRING, J. R. (1992) An

inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell

secretion. Amer. J. Physiol. 279: 43-48.

37. GOLDENRING, J. R., Asher, V. A., Barreuther, M. F., Lewis, J. J., Lohmann, S., Walter, U. and Modlin, I.

M. (1992) Stimulation of isolated gastric parietal cells activates dephosphorylation of membrane-bound

Type II regulatory subunit of cyclic AMP-dependent protein kinase. Am. J. Physiol. 279: 763-773.

38. Petzel, D., Ganz, M. B., Nestler, E. J., Lewis, J. J., GOLDENRING, J. R., Akcicek, F. and Hayslett, J. P.

(1992) Correlates of aldosterone-induced increases in Ca2+ and Isc suggest that Ca2+ is the second

messenger for stimulation of apical membrane conductance. J. Clin. Invest. 89: 150-156.

39. Tang, L. H., Stoch, S. A., Modlin, I. M. and GOLDENRING, J. R. (1992) Identification of rab2 as a

tubulovesicle-membrane associated protein in rabbit parietal cells. Biochem. J. 285: 715-719.

40. Reubi, J. C., Waser, B., Horisberger, U., Halter, F., Soroka, C. J., Kumar, R. R., GOLDENRING, J. R. and

Modlin, I. M. (1992) Enterochromaffin-like cells from mastomys gastric tumors possess receptors for

somatostatin and gastrin. Endocrinology. 131: 166-172

41. Funasaka, M., Fox, L. M., Tang, L. H., Modlin, I. M. and GOLDENRING, J. R. (1992) The major

calmodulin-binding protein in rabbit parietal cells is Ca2+- calmodulin-dependent protein kinase II.

Biochemistry Internat. 27: 1101-1109.

42. Modlin, I. M., Kumar, R., Soroka, C. J., Pasikhov, D., Nangia, A. and GOLDENRING, J.R. (1992) Gastrin

dependent inhibitory effects of Octreotide on the genesis of gastric ECLomas. Surgery. 112: 1048-1056.

43. Dempsey, P. J., GOLDENRING, J. R., Soroka, C. J., Modlin, I. M., McClure, R. W., Lind, C. D., Ahlquist,

D. A., Pittelkow, M. R., Lee, D. C., Sandgren, E. P., Page, D. L. and Coffey, R. J. (1992) Possible role of

TGF in the pathogenesis of Menetrier’s Disease: Supportive evidence from humans and transgenic mice.

Gastroenterology. 103:1950-1963.

44. Soroka, C. J., Chew, C. S., Modlin, I. M., Hanzel, D., Smolka, A. and GOLDENRING, J. R. (1993)

Characterization of membrane and cytoskeletal compartments in cultured parietal cells using

immunofluorescence and confocal microscopy. Eur. J. Cell Biol. 60: 76-87.

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45. Tsunoda, Y., Modlin, I. M. and GOLDENRING, J. R. (1993) Tyrosine kinase activities in the modulation

of stimulated parietal cell secretion. Am. J. Physiol. 264: G351-G356.

47. GOLDENRING, J. R., Tsunoda, Y., Stoch, S.A., Coffey, R. J. and Modlin, I. M. (1993) Transforming

growth factor-alpha (TGF) inhibition of parietal cell secretion: Structural requirements for activity.

Regulatory Peptides. 43: 37-47.

47. Matovcik, L., Haimowitz, B, GOLDENRING, J. R., Czernik, A. and Gorelick, F. S. (1993) Distribution of

the multifunctional calmodulin-dependent protein kinase in ileal mucosa. Am. J. Physiol. 264:C1029-C1036.

48. Ballantyne, G. H., GOLDENRING, J. R., Fleming, F. X., Rush, S., Flint, J. S., Fielding, L. P., Binder, H. J.

and Modlin, I. M. (1993) Inhibtion of vasoactive intestinal polypeptide-stimulated ion transport by a novel

Y-receptor phenotype in the rabbit distal colon. Am. J. Physiol. 264:G848-854..

49. Ballantyne, G. H., GOLDENRING, J. R., Savoca, P. J., Kranz, H. K., Adrian, T. E., Bilchik, A. J. and

Modlin, I. M. (1993) Cyclic AMP-mediated release of peptide YY (PYY) from the isolated perfused rabbit

distal colon. Regulatory Peptides. 47: 117-126.

50. GOLDENRING J.R., Shen, R.K., Vaughan, H.D. and Modlin, I.M. (1993) Identification of a small GTP-

binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney and lung. J. Biol. Chem. 268:

18419-18422.

51. Mamiya, N., GOLDENRING, J.R., Tsunoda, Y., Modlin, I.M., Yasui, K., Usuda, N., Ishikawa, T., Natsume,

A. and Hidaka, H. (1993) Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-

dependent protein kinase II inhibitor KN-93. Biochem. Biophys. Res. Commun. 195: 608-615.

52. Modlin, I. M., Kumar, R. R., Soroka, C. J. and GOLDENRING, J. R. (1994) Histamine as an intermediate

growth factor in the genesis of gastric ECLomas associated with hypergastrinemia in Mastomys. Dig. Dis.

Sci. 39:1446-1452.

53. Tang, L. H., Miller, M. D., GOLDENRING, J. R., Modlin, I. M. and Hersey, S. J. (1993) Partial agonism

by gastrin for a CCK receptor mediating pepsinogen secretion. Am. J. Physiol. 265:G865-G872.

54. GOLDENRING, J.R., Soroka, C.J., Shen, R.K., Tang, L.H., Rodriguez, W., Vaughan, H.D., Stoch, S.A. and

Modlin, I.M. (1994) Enrichment of rab11, a low molecular weight GTPase, in gastric parietal cells. Amer.

J. Physiol. 267:G187-G194.

55. Chough, S.P., GOLDENRING, J.R., Hurst, R.D., Ballantyne, G.H. and Modlin, I.M. (1994) Calcium

modulation of the effects of serotonin, carbachol and histamine on rabbit ileal ion transport. Yale J. Biol.

Med. 66:1-16.

56. Bergh, C.M., Brophy, C.M., Dransfield, D.T., Lincoln, T., GOLDENRING, J.R. and Rasmussen, H. (1994)

Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle. Amer. J.

Physiol. 268:H202-H212.

57. Quin, J.A., Sgambati, S.A., GOLDENRING, J.R., Basson, M.D., Fielding, L.P., Modlin, I.M. and

Ballantyne, G.H. (1995) PYY inhibition of VIP-stimulated ion transport in the rabbit distal ileum J. Surg.

Res. 58:111-115.

58. Tang, L.H., Modlin, I.M., Caulfield, T.A. and GOLDENRING, J.R. (1995) A novel serine kinase activity

associated with exocrine secretory granules. Am. J. Physiol. 269:G481-G489.

59. Dransfield, D.T., Bradford, A.J. and GOLDENRING, J.R. (1995) Characterization of A-kinase anchoring

proteins in parietal cells. Biochim. Biophys. Acta. 1269: 215-220.

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60. GOLDENRING, J.R., Smith, J., Vaughan, H.D., Cameron, P., Hawkins, W. and Navarre, J. (1996) Rab11

is an apically located small GTP-binding protein in epithelial tissues. Am. J. Physiol. 270:G515-G525.

61. GOLDENRING, J.R., Ray, G.S., Soroka, C.J., Smith, J., Modlin, I.M., Meise, K.S. and Coffey, R.J., Jr.

(1996) Over-expression of transforming growth factor-alpha alters the differentiation of gastric cell lineages.

Dig. Dis. Sci. 41:773-784.

62. Canfield, V.A., West, A.B., GOLDENRING, J.R. and Levenson, R. (1996) Targeted ablation of parietal

cells in transgenic mice. Proc. Natl. Acad. Sci., USA. 93:2431-2435.

63. GOLDENRING, J.R., Ray, G.S., Poulsom, R., Wright, N., Coffey, R.J., Jr. (1996) Distribution of trefoil

peptide expression in gastric mucosa of normal and MT-TGF mice. Growth Factors. 13:111-119.

64. Sheehan, D., Ray, G.S., Calhoun, B.C. and GOLDENRING, J.R. (1996) A somatodendritic distribution of

Rab11 in rabbit brain neurons. NeuroReport. 7:1297-1300.

65. Parente, J.A., GOLDENRING, J.R., Petropoulos, A.C., Hellman, U. And Chew, C.S. (1996) Purification,

cloning and expression of a novel endogenous, calcium-sensitive, 28 kDa phosphoprotein. J. Biol. Chem.

271:20096-20101.

66. Modlin, I.M., Zho, Z., Tang, L.H., Kidd, M., Lawton, G.P., Miu, K., Powers, R.E., GOLDENRING, J.R.,

Pasikhov, D. And Soroka, C.J. (1996) Evidence for a regulatory role for histamine in gastric

enterochromaffin-like cell proliferation induced by hypergastrinemia. Digestion. 57: 310-321.

67. Navarre, J., Bradford, A.J., Calhoun, B.J. and GOLDENRING, J.R. (1996) Quenching of endogenous

peroxidase in ECL western blot. Biotechniques. 21:990-992.

68. Matovcik, L.M., Maranto, A.R., Soroka, C.J., Gorelick, F.S., Smith, J. and GOLDENRING, J.R. (1996)

Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical

domain of gastrointestinal mucosal cells. J. Histochem. Cytochem. 44:1243-1250.

69. Ray, G.S., Jackson, M.W. and GOLDENRING, J.R. (1996) Foveolar hyperplasia following partial

gastrectomy results from expansion of the surface mucous cell compartment. Dig. Dis. Sci. 41: 2016-2024.

70. Calhoun, B. C. And GOLDENRING, J. R. (1996) Rab proteins in gastric parietal cells: Evidence for the

membrane recycling hypothesis. Yale J. Biol. Med. 69: 1-8.

71. Dransfield, D.T. , Bradford, A.J., Yeh, J., and GOLDENRING, J.R. (1997) Identification and

characterization of a novel A-kinase anchoring protein (AKAP120). Biochem J. 322:801-807.

72. Dransfield, D. T., Bradford, A.J., Martin, M., Mangeat, P.H. and GOLDENRING, J.R. (1997) Ezrin is a

cyclic AMP-dependent protein kinase anchoring protein (AKAP). EMBO J. 16:35-43.

73. Beall, A.C., Kato, K., GOLDENRING, J.R., Rasmussen, H. and Brophy, C.M. (1997) Cyclic nucleotide-

dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein. J.

Biol. Chem. 272:11283-11287.

74. Calhoun, B.C. and GOLDENRING, J.R. (1997) Two Rab proteins,VAMP-2 and SCAMPs are present on

immunoisolated parietal cell tubulovesicles. Biochem. J. 325:559-564.

75. Joshi, V., Ray, G.S. and GOLDENRING, J.R. (1997) Inhibition of parietal cell acid secretion is mediated

by the classical epidermal growth factor receptor. Dig. Dis. Sci. 42:1194-1198.

GOLDENRING: Page 23

76. Koh, T.J., GOLDENRING, J.R., Ito, S., Mashimo, H., Kopin, A.S., Varro, A., Dockray, G. and Wang, T.C.

(1997) Gasstrin deficiency results in altered gastric differentiation and decreased colonic proliferation.


77. Ray, G.S., Lee, J. Nwokeji, K., Mills, L., and GOLDENRING, J.R. (1997) Increased immunoreactivity for

Rab11, a small GTP-binding protein, in low grade dysplasic BarrettÕ s epithelia. Lab. Invest. 77:503-511.

78. Green, E.G., Ramm, E., Riley, N.M., Spiro, D.J., GOLDENRING, J.R. and Wessling-Resnick, M. (1997)

Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem. Biophys.

Res. Commun. 239:612-617.

79. Okamoto, C. T., Karam, S. M., Jeng, Y. Y., Forte, J.G. and GOLDENRING, J.R. (1998) Identification of a

clathrin adapter (AP-1)-related complex on tubulovesicles of gastric acid secretory (oxyntic) cells. Am. J.

Physiol. 274:C1017-C1029.

80. Wang, T.C., GOLDENRING, J.R., Dangler, C., Millar, A., Jeon, W.K., Ito, S., Koh, T.J. and Fox, J.G.

(1998) C57BL/6 mice deficient in secretory phospholipase A2 show increased apoptosis and altered cellular

differentiation during Helicobacter felis infection. Gastroenterology. 114:675-689.

81. Bhartur, S. G. and GOLDENRING, J.R. (1998) Mapping of ezrin dimerization using yeast two-hybrid

screening. Biochem. Biophys. Res. Commun. 243:874-877.

82. Calhoun, B.C., Lapierre, L.A., Chew, C.S. and GOLDENRING, J.R. (1998) Rab11 redistributes to the

apical secretory canaliculus during stimulation of gastric parietal cells. Amer. J. Physiol. 275: C163-C170.

83. Majumdar, A.P.N. and GOLDENRING, J.R. (1998) Localizaiton and significance of pp55, a gastric

mucosal membrane protein with tyrosine kinase activity. Amer. J. Physiol. 274:G863-G870.

84. Casanova, J.E., Wang, X., Kumar, R., Bhartur, S.G., Navarre, J., Woodrum, J.E., Ray, G.S. and

GOLDENRING, J.R. (1999) Rab11a and Rab25 association with the apical recycling system of polarized

MDCK cells. Mol. Biol. Cell. 10:47-61.

85. Schmidt, P.H., Dransfield, D.T., Claudio, J.T., Hawley, R.G., Trotter, K.W., Milgram, S.L. and

GOLDENRING, J.R. (1999) AKAP350: A multiply spliced A-kinase anchoring protein associated with

centrosomes. J. Biol. Chem. 274: 3055-3066.

86. Schmidt, P.H., Lee, J.R., Joshi, V., Playford, R.J., Poulsom, R., Wright, N.A. and GOLDENRING, J.R.

(1999) Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab.

Invest. 79:639-646.

87. Song, S.Y., Gannon, M., Washington, M.K., Scogins, C.R., Meszoely, I.M., GOLDENRING, J.R., Marino,

C.R., Sandgren, E.P., Coffey, R.J., Jr., Wright, C.V.E. and Leach, S.D. (1999) Expansion of pdx1-

expressing pancreatic epithelium and initiation of islet neogenesis in transgenic mice overexpressing TGF.


88. Lapierre, L.A., Tuma, P.L., Navarre, J., GOLDENRING. J.R. and Anderson, J.M. (1999) VAP-33

localizes to both an intracellular vesicle population and with occludin at the tight junction. J. Cell Sci.

112:3723-3732.

89. GOLDENRING, J.R., Ray, G.S. and Lee, J.R. (1999) Rab11 in dysplasia of Barrett’s epithelia. Yale J.

Biol. Med. 72:113-120.

90. Wang, T.C., Dangler, C.A., Chen, D., GOLDENRING, J.R., Koh, T., Raychowdhury, R., Coffey, R.J., Ito,

S., Varro, A., Cockray, G.J. and Fox, J.G. (2000) Synergistic interaction between hypergastrinemia and

Helicobacter infection in a gastric cancer mouse model. Gastroenterology. 118:36-47.

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91. Bhartur, S.G., Calhoun, B.C., Woodrum, J., Kurkjian, J., Iyer, S., Lai, F. and GOLDENRING, J.R. (2000)

Genomic structure of murine Rab11 family members. Biochem. Biophys. Res. Commun. 269:611-617.

92. GOLDENRING, J.R., Ray, G.S., Coffey, R.J., Jr., Meunier, P., Haley, P., Barnes, T.B., Car, B.D. (2000)

Reversible drug-induced oxyntic atrophy in rats. Gastroenterology. 118: 1080-1093.

93. Wang, X., Kumar, R., Navarre, J., Casanova, J.E. and GOLDENRING, J.R. (2000) Regulation of

membrane trafficking in MDCK cells by Rab11a and Rab25. J. Biol. Chem. 275:29138-29146.

94. Burdick, J.S., Chung, E., Lindberg, G., Tanner, G., Washington, K., GOLDENRING, J.R. and Coffey, R.J.

(2000) Treatament of Menetrier’s disease with a monoclonal antibody against epidermal growth factor

receptor. New Eng. J. Med. 343:1697-1701.

95. Lee, M.P., Ravenal, J.D., Hu, R., Lustig, L.R., Tomaeli, G., Brandenburg, S.A., Litzi, T.J., Bunton, T.E.,

Limb, C., Francis, H., Gorelikow, M., Gu, H., Washington, K., Argani, P., GOLDENRING, J.R., Coffey,

R.J., and Feinberg, A.P. (2000) Targeted disruption of the Kvlqt1 gene cause deafness and gastric

hyperplasia in mice. J. Clin. Invest. 106:1447-1455.

96. GOLDENRING, J.R., Aron, L.M., Lapierre, L.A., Navarre, J. and Casanova, J.E. (2001) Expression and

properties of Rab25 in polarized Madin-Darby canine kidney cells. Meth. Enzymol. 329:225-234.

97. Lapierre, L.A., Kumar, R., Hales, C.M., Navarre, J., Bhartur, S.G., Burnette, J.O., Provance, W., Jr., Mercer,

J., Bahler, M. and GOLDENRING, J.R. (2001) Myosin Vb is associated with plasma membrane recycling

systems. Mol. Biol. Cell. 12:1843-1857.

98. Wang, E., Pennington, J.G., GOLDENRING, J.R., Hunziker, W. and Dunn, K.W. (2001) Brefeldin A

rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells.

J. Cell Sci. 114:3309-21.

99. Hales, C.M., Griner, R., Hobdy-Henderson, K.C., Navarre, J., Dorn, M.C., Hardy, D., Kumar, R., Chan,

E.K.L., Lapierre, L.A. and GOLDENRING, J.R. (2001) Identification and characterization of a family of

Rab11 interacting proteins. J. Biol. Chem. 276:39067-75.

100. Yamaguchi, H., GOLDENRING, J.R., Kaminishi, M. and Lee, J.R. (2002) Identification of spasmolytic

polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy

biopsies. Dig. Dis. Sci. 47:573-8.

101. Steadman, B., Schmidt, P.H., Shanks, R.A., Lapierre, L.A. and GOLDENRING, J.R. (2002) A novel

TACC family member (TACC4) associates with AKAP350 at centrosomes. J. Biol. Chem. 277:30165-

30176.

102. Yamaguchi, H., GOLDENRING, J.R., Kaminishi, M. and Lee, J.R. (2002) Association of spasmolytic

polypeptide expressing metaplasia (SPEM) with carcinogen administration and oxyntic atrophy in rats. Lab.

Invest. 82:1045-1052.

103. Shanks, R.A., Schmidt, P.H., Steadman, B. and GOLDENRING, J.R. (2002) A-kinase anchoring protein

350 (AKAP350) at the Golgi apparatus. I. Identification of a Golgi apparatus targeting motif. J. Biol. Chem.

277:40967-40972.

104. Shanks, R.A., Berryman, M., Edwards, J.C., Urushidani, T., Navarre, J. and GOLDENRING, J.R. (2002) A-

kinase anchoring protein 350 (AKAP350) at the Golgi apparatus. II. Interaction with a novel chloride

intracellular channel (CLIC) protein family member. J. Biol. Chem. 277: 40973-40980.

GOLDENRING: Page 25

105. Volpicelli, L.A., Lah, J.J., Fang, G., GOLDENRING, J.R. and Levey, A.I. (2002) Rab11a and myosin Vb

regulate recycling of the M4 muscarinic acetylcholine receptor. J. Neurosci. 22: 9776-9784.

106. Hales, C.M., Vaerman, J-P. and GOLDENRING, J.R. (2002) Rab11-Family Interacting Protein 2 (Rab11-

FIP2) associates with myosin Vb and regulates plasma membrane recycling. J. Biol. Chem. 277: 50415-

50421.

107. Fan, G-H. Lapierre, L.A., GOLDENRING, J.R. and Richmond, A. (2003) Differential regulation of

CXCR2 trafficking by Rab GTPases. Blood. 101:2115-24.

108. Haldorsdottir, A.M., Siggurdsdottir, M., Jonasson, J.G., Oddsdottir, M., Magnusson, J., Lee, J.R. and

GOLDENRING, J.R. (2003) Spasmolytic polypeptide expressing metaplasia (SPEM) associated with

gastric cancer in Iceland. Dig. Dis. Sci. 48:431-441.

109. Lee, J.R., Baxter, T., Wang, T.C., GOLDENRING, J.R., and Anderson, M. (2003) Differential protein

analysis of spasmolytic polypeptide expressing metaplasia using laser capture microdissection and 2-

dimensional difference gel electrophoresis. Applied. Immunocytochem. Molec. Morphology. 11:188-193.

110. Lapierre, L., Dorn, M.C., Zimmerman, C.F., Navarre, J., Burnette, J.O. and GOLDENRING, J.R. (2003)

Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells.

Exp. Cell Res. 290:322-331.

111. Berryman, M.A. and GOLDENRING, J.R. (2003) CLIC4 is enriched at cell-cell junctions and colocalizes

with AKAP350 at the centrosome and midbody of cultured mammalian cells. Cell Motil. Cytoskel. 56:

159-172.

112. Hobdy-Henderson, K.C., Hales, C.M., Lapierre, L.A., Cheney, R.E. and GOLDENRING, J.R. (2003)

Dynamics of the apical plasma membrane recycling system during cell division. Traffic. 4:681-693.

113. Brock, S.C, GOLDENRING, J.R. and Crowe, J.E. (2003) Apical recycling systems regulate directional

budding of respiratory syncytial virus from polarized epithelial cells. Proc. Natl. Acad. Sci., USA. 100:

15143-8.

114. Provance, D.W., Jr., Gourley, C.R., Silan, C.M., Cameron, L.C., Shokat, K.M., GOLDENRING, J.R., Shah,

K., Gillespie, P.G. and Mercer, J.A. (2004) Chemical-genetic inhibition of a sensitized mutant myosin-Vb

demonstrates a role in peripheral-pericentriolar membrane traffic. Proc. Natl. Acad. Sci., USA. 101: 1868-

1873.

115. Fan, G-H., Lapierre, L.A., GOLDENRING, J.R., Sai, J. and Richmond, A. (2004) Rab11-family interacting

protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Mol. Biol.

Cell. 15:2456-2469.

116. Smolka, A.J., GOLDENRING, J.R., Gupta, S. and Hammond, C.E. (2004) Inhibition of gastric H,K-

ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC

Gastroeterology. 4:4.

117. Larocca, M.C., Shanks, R.A., Tian,, L, Nelson, D.L., Stewart, D.M., and GOLDENRING, J.R. (2004)

AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus. Mol. Biol. Cell. 15:2771-81.

118. Li, Y., Wandinger-Ness, A., GOLDENRING, J.R. and Cover T.L. (2004) Clustering and redistribution of

late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Mol. Biol. Cell.

15:1946-1959.

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119. Nomura, S., Baxter, T., Leys, C., Yamaguchi, H., Vartapetian, A.B., Lee, J.R., Wang, T.C. and

GOLDENRING, J.R. (2004) Relationship of Spasmolytic Polypeptide Expressing Metaplasia (SPEM) to

pre-neoplasia in H. felis-infected mice. Gastroenterology. 127:582-594.

120. Nomura, S, Yamaguchi, H.,.Wang, T.C., Lee, J.R and GOLDENRING, J.R. (2005) Alterations in gastric

mucosal lineages by acute oxyntic atrophy in wild type and gastrin deficient mice. Amer. J. Physiol.

288:G362-375.

121. Houghton, J., Stoicov, C., Nomura, S., Carlson, J., Li, H., Rogers, A., Fox, J.G., GOLDENRING, J.R. and

Wang, T.C. (2004) Gastric neoplasia originates from bone marrow derived stem cells. Science. 306:1568-

1571.

122. Greengauz-Roberts, O., Stoppler, H., Nomura, S., Yamaguchi, H., GOLDENRING, J.R., Podolsky, R.H.,

Lee, J.R. and Dynan, W.S. (2005) Saturation labeling of cysteine-reactive cyanine fluorescent dyes

provides increased sensitivity for protein expression profiling of laser microdissected clinical specimens.

Proteomics 5:1746-1757.

123. Nomura, S., Settle, S.H., Leys, C., Means, A.L., Peek, R., Leach, S.D., Wright, C.V., Coffey, R.J., and

GOLDENRING, J.R. (2005) Evidence for repatterning of the gastric fundic epithelium associated with

Menetrier’s disease and TGF overexpression. Gastroenterology. 128:1292-1305.

124. Lapierre, L.A. and GOLDENRING, J. R. (2005) Interactions of Myosin Vb with Rab11 family members

and cargoes traversing the plasma membrane recycling system. Meth. Enzymol. 403:715-23.

125. Ducharme, N.A., Jin, M., Lapierre, L.A. and GOLDENRING, J. R. (2005) Assessment of Rab11-FIP2

Interacting Proteins in vitro. Meth. Enzymol. 403:706-15.

126. Ogawa, M., Nomura, S., Carr, B.D., and GOLDENRING, J.R. (2006) Omeprazole treatment ameliorates

oxyntic atrophy induced by DMP-777. Dig. Dis. Sci. 51:431-9.

127. Robert ME, Washington MK, Lee JR, GOLDENRING JR, Bronner MP, Goldblum JR, Greenson JK, Haber

MM, Hart JA, Lamps LW, Lauwers GY, Lewin D, Lazenby AJ, Montgomery E, Crawford JM. (2006)

Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in

Barrett esophagus. Am. J. Clin. Pathol. 124:1-9.

128. Lise MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-

Husseini A. (2006) Involvement of myosin Vb in glutamate receptor trafficking. J. Biol. Chem. 281:3669-78.

129. Leys, C.M., Nomura, S., LaFleurr, B.J., Ferrone, S., Kaminishi, M., Montgomery, E., and

GOLDENRING, J. R. (2007) Expression and prognostic significance of prothymosin- and ERp57

in human gastric cancer. Surgery. 141:41-50.

130. Ogawa, M., Nomura, S., Varro, A., Wang, T.C. and GOLDENRING, J.R. (2006) Altered

metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Amer. J.

Physiol., 290:G793-804.

131. Welch DC, Wirth PS, Goldenring JR, Ness E, Jagasia M, Washington K. (2006)

Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic

gastric biopsy interpretation? Am J Surg Pathol. 30:444-449.

132. Varthakavi V, Smith RM, Martin KL, Derdowski A, Lapierre LA, Goldenring JR, Spearman P. (2006) The

pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release.

Traffic. 7:298-307.

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Trinh+A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Hines+RM%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Liu+L%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Kang+R%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Hines+DJ%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lu+J%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Goldenring+JR%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Wang+YT%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22El%2DHusseini+A%22%5BAuthor%5D

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133. Ducharme, N.A., Hales, C.M., Lapierre, L.A., Ham, A.L., Oztan, A., Apodaca, G. and GOLDENRING, J.R.

(2006) MARK2 phosphorylation of RAB11-FIP2 modulates the establishment of polarity in MDCK cells.

Molec. Biol. Cell. 17:3625-3637.

134. Larocca, M.C., Jin, M. and GOLDENRING, J.R. AKAP350 modulates microtubule dynamics. (2006) Eur.

J. Cell Biol. 85:611-619.

135. Leys, C.M., Nomura, S., Rudzinski, E., Kaminishi, M., Montgomery, E., Washington, M.K. and

GOLDENRING, J.R. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma.

(2006) Human Pathol. 37:1162-1168.

136. GOLDENRING, J. R. and Nomura, S. (2006) Differentiation of the gastric mucosa III. Animal models of

oxyntic atrophy and metaplasia. Amer. J. Physiol. 291:G999-G1004.

137. Pooley RD, Reddy S, Soukoulis V, Roland JT, Goldenring JR, Bader DM. (2006) CytLEK1 is a regulator of

plasma membrane recycling through its interaction with SNAP-25. Molec. Biol. Cell. 7:3176-3186.

138. Jin, M. and GOLDENRING, J.R. (2006) The Rab11-FIP1/RCP gene codes for multiple protein transcripts

related to the plasma membrane recycling system. Biochim. Biophys. Acta: Gene Express. Regul. 1759:281-

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139. Lang, M.R., Lapierre, L.A., Frotscher, M., GOLDENRING, J.R. and Knapik, E.W. (2006) Secretory COPII

coat component Sec23a is essential for craniofacial chondrocyte maturation. Nature Genetics. 38:1198-203.

140. Nedvetsky PI, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, Hammer JA 3rd, Nielsen S,

GOLDENRING JR, Rosenthal W, Klussmann E. (2007) A Role of myosin Vb and Rab11-FIP2 in the

aquaporin-2 shuttle. Traffic. 8:110-123.

141. Nam, K.T., Varro, A., Coffey, R.J. and GOLDENRING, J.R. (2007) Potentiation of oxyntic atrophy-

induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology. 132:1804-19.

142. Neel, N., Lapierre, L.A., GOLDENRING, J.R. and Richmond, A. (2007) RhoB plays an essential role in

CXCR2 sorting decisions. J. Cell. Science. 120:1559-71.

143. Lapierre, L.A., Avant, K., Caldwell, C.M., Ham, A.L., Hill, S., Williams, J., Smolka, A.J. and

GOLDENRING, J.R. (2007) Characterization of immmunoisolated human gastric tubulovesicles:

identification of regulators of apical recycling in gastric parietal cells. Amer. J. Physiol., Gastro. Liver

Physiol. 292:G1249-62.

144. Que, J., Okubo, T., GOLDENRING, J.R., Nam, K.T., Taranova, O., Pevny, L.H. and Hogan, B.L.M. (2007)

Sox2 plays a dose-dependent role in the differentiation and morphogenesis of anterior foregut endoderm.

Development. 134:2521-31.

145. Roland, J.T., Kenworthy, A.K., Peranen, J., Caplan, S. and GOLDENRING, J.R. (2007) Myosin Vb

interacts with Rab8a on a tubular network containing EHD1 and EHD3. Molec. Biol. Cell. 18:2828-37.

146. Ducharme, N., Williams, J.A., Oztan, A., Apodaca, G. and GOLDENRING, J.R. (2007) Dominant negative

Rab11-FIP2 mutants uncover differentiable steps in the apical recycling pathway. Amer. J. Physiol.-Cell

Physiol. 293:C1059-72.

147. Oztan, A., Silvis, M., Weisz, O.A., Bradbury, N.A., Hsu, S.H., GOLDENRING, J.R., Yeaman, C. and

Apodaca, G. (2007) Exocyst requirement for endocytic traffic directed toward the apical and basolateral

poles of polarized MDCK cells. Molec. Biol. Cell. 18:3978-92.

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148. Cresawn, K.O., Potter, B.A., Oztan, A., Guerriero, C.J., Ihrke, G., GOLDENRING, J.R., Apodaca,G. and

Weisz, O.A. (2007) Differential involvement of endocytic compartments in the biosynthetic traffic

of apical proteins. EMBO J. 26:3737-48.

148. Yoshizawa, N., Takenaka, Y., Yamaguchi. H, Tetsuya, T.,Tanaka, H., Tatematsu, M, Nomura, S.,

GOLDENRING, J.R. and Kaminishi, M. (2007) Emergence of Spasmolytic Polypeptide-Expressing

Metaplasia (SPEM) in Mongolian gerbils infected with Helicobacter pylori. Laboratory. Invest. 87:1265-

1276.

149. Donowitz, M., Singh, S., Salahuddin, F.F., Hogema, B.M., Chen, Y., Gucek, M., Cole, R.N,. Zachos, N.C.,

Kovbasnjuk, O., Lapierre, L.A., Broere, N., Ham, A., GOLDENRING, J., Dejonge, H. and Li, X. (2007)

Proteome of murine jejunal brush border membrane vesicles. J. Proteome Res. 6:4068-4079

150. Nozaki, K., Ogawa, M., Williams, J.A. Lafleur, B.J. Ng, V., Drapkin, R.I. Mills, J.C. Konieczny, S.

Nomura, S. and GOLDENRING, J.R. (2008) A molecular signature of gastric metaplasia arising in

response to acute parietal cell loss. Gastroenterology. 134:511-22.

151. Utley TJ, Ducharme NA, Varthakavi V, Shepherd BE, Santangelo PJ, Lindquist ME, GOLDENRING JR,

Crowe JE Jr. (2008) Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled

by Rab11-FIP2. Proc Natl Acad Sci U S A. 105:10209-14.

152. Schonteich, E., Wilson, G.M., Burden, J., Hopkins, C.R., Anderson, L., GOLDENRING, J.R. and Prekeris,

R. (2008) Rip11/Rab11-FIP5 and Kinesin II complex regulates endocytic protein trafficking. J. Cell Sci.

121:3824-3833.

153. Cao, Z., L, C., Higginbotham, J.N., Franklin, J.L., Tabb, D.L., Graves-Deal, R., Hill, S., Cheek, K.,

Lapierre, L.A., GOLDENRING, J.R., Ham, A.L. Coffey, R.J. (2008) Use of fluorescence-activated vesicle

sorting for isolation of Naked2-associated, basolaterally-targeted exocytic vesicles for proteomic analysis.

Molec. Cell. Proteomics. 7:1651-1657.

154. Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, GOLDENRING JR, Apodaca G. (2008)

Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci

U S A. 105:15773-8.

155. Kolobova, E., Efimov, A., Kaverina, I, Rishi, A, Schrader, J.W., Ham, A.L., Larocca, M.C. and

GOLDENRING, J.R. (2009) Microtubule-dependent association of AKAP350A and CCAR1 with RNA

stress granules. Exp. Cell Res. 315:542-545.

156. Roland, J.T., Lapierre, L.A. and GOLDENRING J.R. (2009) Alternative splicing in class V myosins

determines association with RAB10. J. Biol. Chem. 284:1213-1223.

157. Nam, K.T., Lee. H-J, Mok, H, Romero-Gallo, J, Crowe, J.E., Jr., Peek, R.M. Jr., and GOLDENRING, J.R.

(2009) Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia, intestinal

metaplasia and invasive neoplasia. Gastroenterology. 136:1288-96.

158 Nozaki, K., Weis, V., Wang, T.C., Falus, A and GOLDENRING, J.R. (2009) Altered gastric chief cell

lineage differentiation in histamine-deficient mice. Amer. J. Physiol., Gastrointest. Liver. Physiol.

296:G1211-20.

159. Aikou, S., Nomura, S., Fukushima, Y., Ogaswa, M., Ishikawa, T., GOLDENRING, J.R. and Kaminishi, M.

(2009) Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in Gastrin receptor and

H2 Histamine receptor deficient mice. Digest. Dis. Sci. 54:1625-35.

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160. Tzaban, S., Massol, R.H., Yen, E., Hamman, W., Frank, S.R., Lapierre, L.A., Hansen, S.H.,

GOLDENRING, J.R., Blumberg, R.S., Lencer, W.I. (2009) The recycling and transcytotic pathways for IgG

transport by FcRn are distinct and display an inherent polarity. J. Cell Biol. 185:673-84.

161. Eggers, C.T, Schafer, J.C., GOLDENRING, J.R., and Taylor, S.S. (2009) D-AKAP2 Interacts With Rab4

and Rab11 Through Its RGS Domains and Regulates Transferrin Receptor Recycling. J. Biol. Chem.

284:32869-80.

162. Fiske, W.H., Tanksley, J., Nam, K.T., GOLDENRING, J.R., Slebos, R.J., Liebler, D.C., LaFleur, B., Ayers,

G.D., Lind, C.D., Washington, M.K. and Coffey, R. J. (2009) Efficacy of Cetuximab in the treatment of

Ménétrier’s disease. Science Translational Medicine. 1:8ra18.

163. GOLDENRING, J.R. (2010) Innocence and due diligence: Dealing with unfounded accusations of

scientific misconduct. Acad. Med. 85:527-30.

164. Frasa, M.A.M., Francis, R., Betson, M.E., Lozano, E., Bleimling, N., GOLDENRING, J.R., Seabra, M.,

Rak, A., Ahmadian, M.R. and Braga, V.M.M. (2010) Armus is a novel Rac1 effector protein that

inactivates Rab7 and regulates E-cadherin stability at junctions. Curr. Biology. 20:198-208.

165. Nam, K.T., Lee, H, Smith, J.J. Lapierre, L.A., Kamath, V.P., Chen, X., Aronow, B.J., Yeatman, T.J.,

Bhartur, S.G., Calhoun, B.C., Condie, B., Manley, N.R., Beauchamp, R.D., Coffey, R.J. and GOLDENRING,

J.R. (2010) Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with

human colorectal adenocarcinoma. J. Clin. Invest. 120:840-9.

166. Lee, H, Nam, K.T., Park, H.S., LaFleur, B.J., Aburatani, H., Kim, W.H., Yang, H. and GOLDENRING,

J.R. (2010) Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in

early stage gastric cancer. Gastroenterology. 138:2207-10.

167. Matthies, H.M.G., Moore, J.L., Saunders,, C., Matthies, D.S., Lapierre, L.A., GOLDENRING, J.R., Blakely,

R.D., and Galli, A. (2010) Rab11a supports amphetamine-stimulated norepinephrine transporter trafficking.

J. Neuroscience. 30:7863-7877.

168. GOLDENRING, J.R. Nam, K.T., Wang, T.C., Mills, J.C. and Wright, N.A. (2010) Spasmolytic

polypeptide-expressing metaplasia and intestinal metaplasia: Time for re-evaluation of metaplasias and the

origins of gastric cancer. Gastroenterology. 139: 213-225.

169. Lennerz, J.K.M, Kim, S., Oates, E.L., Huh, W.J., Doherty, J.M., Tian, X., Bredemeyer, A.J..

GOLDENRING, J.R., Lauwers, G.Y., Shin, Y. and Mills, J.C. (2010) The transcription factor MIST1 is a

novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia and carcinoma.

Amer. J. Pathol. 177:1514-33.

170. Quante, M., Marrache, F., GOLDENRING J.R. and Wang, T.C. (2010) TFF2 mRNA transcript expression

marks a gland progenitor 1 cell of the gastric oxyntic mucosa. Gastroenterology. 139:2018-2027.

171. Shinohara, M., Mao, M., Keeley, T.M., El-Zaatari, M, Lee, H-J., Eaton, K.A., Samuelson, L.C., Merchant,

J.L. GOLDENRING, J.R. and Todisco, A. (2010) Bone Morphogenetic Protein Signaling Regulates

Gastric Epithelial Cell Development and Proliferation in Mice. Gastroenterology. 139:2050-2060.

172. Nam, K.T., Lee, H, Sousa, J.F., Weis, V.G., O’Neal, R., Finke, P.E., Romero-Gallo, J., Shi, G., Mills, J.C.,

Peek, R.M., Jr., Konieczny, S.F. and GOLDENRING, J.R. (2010) Mature chief cells are cryptic progenitors

for metaplasia in the stomach. Gastroenterology. 139:2028-2037.

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173. Roland, J.T.E., Bryant, D.M., Datta, A., Itzen, A., Mostov, K.E. and GOLDENRING, J.R. Rab GTPase-

Myo5B complexes control membrane recycling and epithelial polarization. (2011) Proc. Natl. Acad. Sci.,

USA. 108:2789-94.

174. Lapierre, L.A., Caldwell, C.A., Higginbotham, J.N., Avant, K.M., Hall, J., Beauchamp, R.D.

and GOLDENRING, J.R. (2011) Transformation of rat intestinal epithelial cells by over-expression of

Rab25 is microtubule dependent. Cytoskeleton. 68:97-111.

175. Mattaloni, S.M., Kolobova, E., Favre, C., Marinelli, R.A., GOLDENRING, J.R. and Larocca, M.C. (2012)

AKAP350 is involved in the development of apical “canalicular” structures in hepatic cells HepG2. J. Cell.

Physiology. 227:160-71.

176. Aikou, S., Ohmoto, Y., Gunji, T., Matsuhashi, N., Ohtsu, H., Miura, H., Yamagata, Y., Seto, Y.

GOLDENRING, J.R., Kaminishi, M. and Nomura, S. (2011) Tests for Serum Levels of Trefoil Factor

Family Proteins Can Improve Gastric Cancer Screening. Gastroenterology. 141:837-845.

177. Ducharme, N.A., Ham, A.L. Lapierre, L.A. and GOLDENRING, J.R. (2011) Rab11-FIP2 Influences

multiple components of the endosomal system in polarized MDCK cells. Cellular Logistics. 1:57-68.

178. Suh Y., Lee. H-J, Jung E-J., Kim M., Nam, K.T. GOLDENRING J.R Yang H-K, and Kim W.H. (2012)

The combined expression of metaplasia biomarkers predicts the prognosis of gastric cancer. Annals Surg.

Oncol. 19:1240-1249.

179. Nam, K.T., O’Neal, R.L. Coffey, R.J., Finke, P.E., Barker, N. and GOLDENRING, J.R. (2012)

Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from

Lgr5-expressing cells. Gut. 92:883-895.

180. Lapierre, L.A., Avant, K.M., Caldwell, C.M., Oztan, A Apodaca, G., Ducharme, N.A. and GOLDENRING,

J.R. (2012) Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Molec. Biol. Cell.

23:2302-2318.

181. Mason, T.A., Kolobova, E., Liu, J., Roland, J.T., Chiang, C. and GOLDENRING, J.R. (2012) Darinaparsin

is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules

and Shh signaling. PLOS One, 6:e27699.

182. Lapierre, L.A., Ducharme, N.A., Drake, K.R., GOLDENRING, J.R. and Kenworthy, A.K. (2012)

Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial

cells. Exp. Cell Res. 318:103-13.

183. Nam, K.T., O’Neal, R.L. Lee, YS, Lee, YC, Coffey, R.J. and GOLDENRING, J.R. (2012) Gastric tumor

development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser

curvature. Lab Investigation. 92:883-895.

184. Weis, V.G., Sousa, J.F., Lafleur, B.J., Nam, K.T. Weis, J.A., Finke, P.E., Ameen, N.A., Fox, J.G. and

GOLDENRING, J.R. (2013) Heterogeneity in mouse SPEM lineages identifies markers of metaplastic

progression. Gut. 62:1270-1279.

185. Yamagata, Y., Aikou, S., Fukushima, T., Kataoka, H., Seto, Y., Esumi, H., Kaminishi, M., GOLDENRING,

J.R. and Nomura, S. (2012) Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic

atrophy without altering gastrin levels. Amer. J. Physiol: GI Liver. 303:G1254-61.

186. Shaikh, F.Y., Utley, T.J., Craven, R.E., Rogers, M.C., Lapierre, L.A., GOLDENRING, J.R. and Crowe, J.E.,

Jr (2012) Respiratory syncytial virus assembles into structured filamentous virion particles independently of

host cytoskeleton and related proteins. PLOS One. 7: e40826.

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187. Xiao, C., Feng, R., Engevik, A.C., Martin, J.R., Tritschler, J.A., Schumacher, M., Koncar, R., Roland, J.T.,

Nam, K.T., GOLDENRING, J.R*. and Zavros, Y*. (2013) Sonic Hedgehog contributes to gastric mucosal

restitution after injury. Lab Investigation. 93:96-111. *Dual communicating authors.

188. O’Neal, R.L., Nam, K.T., Lafleur, B.J., Barlow, B., Nozaki, K., Lee, H., Kim, W.H., Yang, H., Shi, C.,

Maitra, A., Montgomery, E., Washington, M.K., El Rifai, W., Drapkin,, R.I. and GOLDENRING, J.R.

(2013) Human Epididymis Protein 4 (HE4) is upregulated in gastric and pancreatic adenocarcinomas.

Human Pathology. 44:734-42.

189. Chumbler, N.M., Farrow, M.A., Lapierre, L.A., Franklin, J., Haslam, D., GOLDENRING, J.R., and Lacy,

D.B. (2012) Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-

independent mechanism. PLOS Pathogens. 8(12):e1003072.

190. Sousa, J.F., Ham, A.L, Nam, K.T., Lee, H., Kim, W.H., Yang, H., Zhang, B., Li, M., Lafleur, B.J. Liebler, D.

and GOLDENRING, J.R. (2012) Proteomic profiling of metaplasia and cancer in the human stomach

reveals metaplastic-specific biomarkers. Amer. J. Pathol. 181:1560-72.

191. Krishnan, M., Lapierre, L.A., Knowles, B.C. and GOLDENRING, J.R. (2013) Rab25 regulates integrin

expression and trafficking in polarized colonic epithelial cells. Molec. Biol. Cell. 24:818-831.

192. Baetz, N.W. and GOLDENRING, J.R. (2013) Rab11-Family Interacting Proteins define spatially and

temporally distinct regions within the dynamic Rab11a-dependent recycling system. Molec. Biol. Cell.

24:643-658.

193. Noto, J.M., Khizanishvili, T., Piazuelo, M.B., Chaturvedi, R., Romero-Gallo, J., Delgado, A.G., Sierra, J.C.,

Krishna, U.S., Suarez, G., Powell, A.E., GOLDENRING, J.R., Coffey, R.J., Yang, V.W., Correa, P., Mills,

J.C., Wilson, K.T. and Peek, R.M., Jr (2012) Helicobacter pylori promotes the expression of Krüppel-like

factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLOS One. 8(1):e54344.

194. Qi, M., Williams, J.A., Chu. H., Chen. X., Wang, J., Ding, L., Akhirome, E., Wen, X., Lapierre, L.A.,

GOLDENRING, J.R.* and Spearman, P.* (2013) Rab11-FIP1C and Rab14 direct plasma membrane sorting

and particle incorporation of the HIV-1 envelope glycoprotein complex. PLOS Pathogens. 9(4):e1003278

*Dual communicating authors.

196. Khandelwal, P., Prakasam, P., Clayton, D.R., Ruiz, W.G. Gallo, L., van Roekel, D. Lukianov, S., Peränen, J.,

GOLDENRING, J.R. and Apodaca, G. (2013) A Rab11a, Rab8a, MYO5b network promotes stretch-

regulated exocytosis in bladder umbrella cells. Molec. Biol. Cell. 24:1007-19.

196. Farrow, M.A., Chumbler, N.M., Lapierre, L.A., Franklin, J.L., Rutherford, S.A., Craven, R.E.,

GOLDENRING, J.R. and Lacy, D.B. (2013) Clostridium difficile toxin B induced necrosis is mediated by

the host epithelial cell NADPH oxidase complex. Proc. Natl. Acad. Sci., USA. 110:18674-9.

197. Mattaloni, S.M., Ferretti, A.C., Tonucci, F.M., Favre, C. GOLDENRING, J.R. and Larocca. M.C. (2013)

Centrosomal AKAP350 modulates the G1/S transition. Cell. Logistics. 3(1):e26331.

198. Schafer, J., Baetz, N., Lapierre, L.A., Roland, J.E. and GOLDENRING, J.R. (2014) Rab11-FIP2 interaction

with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic. 15:292-308.

199. Choi, E., Roland, J.T., Barlow, B.J., O’Neal, R., Rich, A.E., Nam, K.T., Shi, C. and GOLDENRING, J.R.

(2014) Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the

gastric antrum. Gut 63:1711-1720.

200. Petersen, C.P., Weis, V.G., Nam, K.T., Sousa, J.F., Fingleton, B and GOLDENRING, J.R. (2014)

Macrophages promote progression of spasmolytic polypeptide expressing metaplasia (SPEM) following

acute parietal cell loss. Gastroenterology. 144:1727-38.

GOLDENRING: Page 32

201. Knowles, B.C., Roland, J.T., Krishnan, W., Tyska, M.J., Lapierre, L.A., Dickman, P.S., GOLDENRING,

J.R.* and Shub, M.* (2014) Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus

inclusion disease. J. Clin. Invest. 124:2947-62. *Dual corresponding authors.

202. Mason, T.A., GOLDENRING, J.R. and Kolobova, E. (2014) AKAP350C targets to mitochondria via a

novel domain and affects mitochondrial morphology. Cellular Logistics. e943597.

203. Yu, S., Nie, Y., Knowles, B., Sakamori, R., Stypulkowski, E., Das, S., Douard, V., Yang, C.S., Ferraris,

R.P., Bonder, E., GOLDENRING, J.R., Ip, T. and Gao, N. (2014) Sequestration of Toll-like receptor 9 by

Rab11 endosome maintains intestinal epithelial tolerance to microbiota. EMBO J. 33:1882-95.

204. Baetz, N.W. and GOLDENIRNG, J.R. (2014) Distinct patterns of phosphatidylserine localization within

the Rab11a-containing recycling system. Cellular Logistics. 4, e28680.

205. Sousa, J.F., Nam, K.T., Petersen, C,P., Lee, H-J., Yang, H-K., Kim, W.H. and GOLDENRING, J.R. (2016)

miR-30-HNF4γ and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia

markers in the stomach. Gut. 65: 914-924.

206. Weis, W. G., Petersen, C. P., Mills, J. C, Tuma, P.L., Whitehead, R. H. and GOLDENRING, J.R. (2014)

Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of

metaplasia in the stomach. Amer. J. Physiol: GI & Liver Physiol. 307:G777-92.

207. Knowles, B.C., Yu, S., Roland, J.T., Williams, J.A., Alvarado, G.S., Lapierre, L.A., Shub, M., Gao, N.. and

GOLDENRING, J.R. (2015) Rab11a regulates Syntaxin 3 localization and microvillus assembly in

enterocytes. J. Cell Sci. 128:1617-26.

208. Seishima R., Wada T., Tsuchihashi K., Okazaki S., Yoshikawa M., Oshima H., Oshima M., Sato T.,

Hasegawa H., Kitagawa Y., GOLDENRING J.R., Saya H. and Nagano O. (2015) Ink4a/Arf-dependent

Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-dependent Gastric Tumorigenesis.

Cancer Prev Res (Phila). 8:492-501.

209. Choi, E., Petersen, C.P. Lapierre, L.A., Williams, J.A., Weis, V.G. GOLDENRING, J.R. and Nam, K.T.

(2015) Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to

parietal cell loss is regulated by gastrin. Am. J Pathology. 185:2219-31.

210. Yu, S., Hwang, H., Yun, N., GOLDENRING, J. R. and Nam, K. T. (2015) The mRNA and protein levels of

tubulin and β-actin are greatly reduced in the proximal duodenum of mice relative to the rest of the small

intestines. Dig. Dis. Sci. 60:2670-6.

211. Singh, B., Bogatcheva, G., Starchenko, A., Sinnaeve, J., Lapierre, L.A., Williams, J.A., GOLDENRING,

J.R. and Coffey, R.J. (2015) Induction of lateral lumens by disruption of a monoleucine-based basolateral

sorting motif in betacellulin. J. Cell. Sci. 128:3444-55.

212. Tonucci, F.M., Hidalgo, F., Ferretti, A., Favre, C., GOLDENIRNG, J.R., Kaverina, I., Kierbel, A. and

Larocca, M.C. (2015) Centrosomal AKAP350 and CIP4 act in concert to define

centrosome/Golgi polarity in migratory cells. J. Cell Sci. 128:3277-89.

213. Choi, E., Hendley, A., Bailey, J.M., Leach, S.D. and GOLDENRING, J.R. (2016) Expression of activated

Ras activation in gastric chief cells of mice leads to the full spectrum of metaplastic lineage transitions.


214. Weis, V.G., Knowles, B.C., Choi, E., Goldstein, A.E., Williams, J.A., Manning, E.H., Roland, J.T., Lapierre,

L.A. and GOLDENRING, J.R. (2016) Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease

GOLDENRING: Page 33

and reveals an apical macropinocytosis pathway in the neonatal duodenum. Cell. Molec. Gastro. Hepatol.

2: 131-157.

215. Engevik, A.C., Feng, R., Li, J., Mahe, M.M., Oh, S., Aihara, E., Engevik, K.A., Montrose, M., Giraud, A.,

Choi, E., Helmrath, M.A., GOLDENRING, J.R. and Zavros, Y. (2016) The Development of Spasmolytic

Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.

Cell. Mol. Gastroenterol. Hepatol. 2:605-624.

216. Schafer, J., McRae, R. E, Lapierre, L.A. and GOLDENRING, J.R. (2016) Rab11-FIP1A regulates early

trafficking into the recycling endosomes. Exper. Cell Res. 340:259-73.

217. Jeong, S., Choi, E., Petersen, C.P., Roland, J.T., Federico, A., D'Armiento, F.P., Saya, H., Romano, M. and

GOLDENRING, J.R. (2017) Distinct metaplastic and inflammatory phenotypes are associated with

autoimmune versus chronic atrophic gastritis. UEG Journal. 5:37-44.

218. Shimizu, T., Choi, E., Petersen, C.P., Noto, J.M., Romero-Gallo, J., Piazuelo, M.B., Washington, M.K.,

Peek, R.M., Jr. and GOLDENRING, J.R. (2016) Characterization of progressive metaplasia in the gastric

corpus mucosa of Mongolian gerbils infected with Helicobacter pylori. J. Pathol. 239:399-410.

219. Lapierre, L.A., Manning, E.H., Mitchell, K.M., Caldwell, C.M. and GOLDENRING, J.R. (2017)

Interaction of Phosphorylated Rab11-FIP2 with Eps15 Regulates Apical Junction Composition. Molec.

Biol. Cell. 28:1088-1100.

220. Petersen, C.P., Meyer, A.R., De Salvo, C., Choi, E., Schlegel, C., Petersen, A., Prasad, N., Levy, S., Pizarro,

T. and GOLDENRING, J.R. (2018) A signaling cascade of IL-33 to IL-13 regulates metaplasia in the

mouse stomach. Gut. 67:805-817.

221. O’Neil, A. Petersen, C.P., Engevik, A.C., Choi, E. and GOLDENRING, J.R. (2017) Unique cellular

lineage composition of the first gland of the mouse gastric corpus. J. Histochem. Cytochem. 65:47-58.

222. McRae, R., Lapierre, L.A., Manning, E.H. and GOLDENRING, J.R. (2017) Rab11-FIP1 phosphorylation

by MARK2 regulates polarity in MDCK cells. Cell. Logistics. 7(1):e1271498.

223. Weis, V.G., Petersen, C.P., Weis, J.A., Meyer, A.R., Choi, E., Mills, J.C. and GOLDENRING, J.R. (2017)

Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Amer. J. Physiol.: GI &

Hepatol. 312:G67-G76.

224. Choi, E., Lantz, T.L., Vlacich, G., Keeley, T.M., Samuelson, L.C., Coffey, R.J., GOLDENRING, J.R. and

Powell, A.E. (2018) Lrig1+ gastric stem/progenitor cells restore normal gastric lineage cells during

damage recovery in adult mouse stomach. Gut. 67:1595-1605.

225. Burclaff, J., Osaki, L.H., Liu, D., GOLDENRING, J.R. and Mills, J.C. (2017) Targeted apoptosis of

parietal cells is insufficient to induce metaplasia in stomach. Gastroenterology. 152:762-766.

226. Bertaux-Skeirik, N., Wunderlich, M., Teal, E., Mahe, M., Sundaram, N., Gabre, J., Hawkins, J., Jian, G.,

Engevik, A.C., Yang, L., Wang, J., GOLDENRING, J.R., Qualls, J.E., Helmrath, M.A., Diwan, T., Mulloy,

J.C. and Zavros, Y. (2017) CD44 variant isoform 9 emerges in response to injury and contributes to the

regeneration of the gastric epithelium. J. Pathology. 242:463-475.

227. Feng, Q., Bonder, E., Engevik, A.C., Zhang, L., Tyska, M., GOLDENRING, J.R. and Gao, N. (2017)

Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. J. Cell.

Sci. 130:2491-2505.

228. Borza, C.M., Browning Monroe, M.B., Liao, H., Yao, B., Zhang, M., Meiler, J., Skwark, M.J., Harris, R.C.,

Lapierre, L.A., GOLDENRING, J.R., Mathew, S., Hook, M., Rivera, J., Brown, K.L., Leitinger, B., Tyska,

GOLDENRING: Page 34

M., Moser, M., Böttcher, R.T., Zent, R. and Pozzi, A. (2017) Talin regulates Discoidin Domain Receptor

1-mediated cell migration by influencing receptor localization, activation, and recycling. J. Cell. Biol.

Submitted.

229. Kim, S.W., Ehrman, J., Ahn, M., Kondo, J., Crawley, J., GOLDENRING, J.R., Tyska, M.J., Rericha, E.C.

and Lau, K.S. (2017) Microvillar sensation of shear stress induces autophagic flux in the intestinal

epithelium. Molec. Biol. Cell. 28:3043-3056.

230. Vogel, G.F., Janecke, A.R., Krainer, I., Gutleben, K., Witting, B., Mitton, S.G., Mansour. S., Ballauff, A.,

Roland, J.T., Engevik, A.C., Cutz, E., Muller, T., GOLDENRING, J.R., Huber, L.A., Hess, M.W. (2017)

Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with Microvillus Inclusion Disease.

Traffic. 18:453-464.

231. Choi B, Lee HJ, Min J, Choe HN, Choi YS, Son YG, Ahn HS, Suh YS, GOLDENRING JR, Yang HK.

(2017) Plasma expression of the intestinal metaplasia markers CDH17 and TFF3 in patients with gastric

cancer. Cancer Biomark. 19:231-239.

232. Bockerstett, K.A., Osaki, L.H., Peterson, C.P., Cai, C., Nguyen, T., Ford, E.L., Hoft, D.F., Mills, J.C.,

GOLDENRING, J.R. and DiPaolo, R. (2018) Interleukin-17A promotes parietal cell atrophy by inducing

apoptosis. Cell. Molec. Gastroenterol. Hepatol. 5:678–690.

233. Kolobova, E., Roland, J.T., Lapierre, L.A., Williams, J.A., Mason, T.A. and GOLDENRING, J.R. (2017)

The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-

nucleation centers and interacts with pericentriolar proteins. J. Biol. Chem. 292:20394-20409.

234. Schlegel, C., Weis, V.G., Knowles, B.C., Lapierre,, L.A., Martin, M.G., GOLDENRING, J.R. and Shub,

M.D. (2018) Apical membrane alterations in non-intestinal organs in Microvillus Inclusion Disease. Dig.

Dis. Sci. 63:356-365.

235. Kirschman, J., Qi, M., Ding, L., Hammonds, J., Dienger-Stambaugh, K., Wang, J., Lapierre, L.A.,

GOLDENRING, J.R. and Spearman, P. (2017) HIV-1 Envelope Glycoprotein Trafficking through the

Endosomal Recycling Compartment is Required for Particle Incorporation. J. Virology. 92:e01893-17.

236. Yu, S., Yang, M., Cho, Y., Kim, H., Lee, K., Jeong, S. Coffey, R.J., GOLDENRING, J.R., Lim, K. and

Nam, K.T. (2018) Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during

different stages of gastric carcinogenesis. Amer. J. Pathol. 188:2912-2923.

237. Means, A.L., Freeman1, T.J., Zhu, J., Woodbury, L.G., Wu, C., Meyer, A.R., Weaver, C.J., Padmanabhan,

C., An, H., Zi, J., Wessinger, B.C., Chari, T., Chaturvedi, R., Brown, T.D., Deane, N.G., Coffey, R.J.,

Wilson, K.T., Smith, J.J., GOLDENRING, J.R., Washington, M.K., Shi, C., and Beauchamp, R.D.. (2018)

SMAD4 pathways suppress induction of inflammatory genes and inflammation-induced carcinogenesis in

colon epithelial cells. Cell. Molec. Gastroenterol. Hepatol. 6:257-276.

238. Yamamoto, M., Nomura, S., Hosoi, A., Nagaoka, K., Iino, T., Yasuda, T., Saito, T., Matsushita, H., Uchida,

E., Seto, Y., GOLDENRING, J.R., Kakimi, K., Tatematsu, M. and Tsukamoto, T. (2018) Established

gastric cancer cell lines transplantable into C57BL/6 mice demonstrate FGFR4 promotion of tumor growth.

Cancer Science. 109:1480-1492.

239. Schlegel, C., Lapierre, L.A., Kaji, I., Weis, V.G., Williams, J.A., Pinzon-Guzman, C., Prasad, N., Boone, B.,

Jones, A., Correa, H., Levy, S.E., Han, X., Wang, M., Thomsen, K., Acra, S. and GOLDENRING, J.R.

(2018) Reversible deficits in apical transporter trafficking associated with DGAT1 deficiency. Traffic.

19:879-892.

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240. Pinzon-Guzman, C., Meyer, A.R., Wise, R., Choi, E., Muthupalani, S., Wang, T.C., Fox, J.G. and

GOLDENRING, J.R. (2019) Evaluation of lineage changes in the gastric mucosa following infection with

Helicobacter pylori and specified intestinal flora in INS-GAS mice. J. Histochem. Cytochem. 67:53–63.

241. Engevik, A.C., Kaji, I., Engevik, M.A., Meyer, A.R., Weis, V.G., Goldstein, A., Hess, M.W., Dudeja, P.,

Shub, M.D., Ameen, N. and GOLDENRING, J.R. (2018) Loss of MYO5B leads to reductions in Na+

absorption with maintenance of CFTR-dependent Cl- secretion in enterocytes. Gastroenterology. 155:1883-

1897.

242. Choi, E., Means, A.L., Coffey, R.J. and GOLDENRING, J.R. (2019) Active Kras-induced gastric

stem/progenitor cells develop foveolar hyperplasia, not metaplasia. Cell. Molec. Gastroenterol. Hepatol.

7:251-253.

243. Meyer, A.R., Engevik, A.C., Willet, S.G., Williams, J.A., Zhou, Y., Massion, P.P., Mills, J.C., Choi, E. and

GOLDENRING, J.R. (2019) Cystine/glutamate antiporter (xCT) is required for chief cell plasticity after

gastric injury. Cell. Molec. Gastroenterol. Hepatol. In Press.

244. Yang, Q., Yasuda, T., Choi, E. Toyoda, T., Roland, J.T., Uchida, E., Yoshida, H., Seto, Y.,

GOLDENRING, J.R. and Nomura, S. (2019) MEK inhibitor treatment reverses metaplasia and allows re-

emergence of normal lineages in H. pylori-infected gerbils. Gastroenterology. 156:577-581.

245. Pinzon-Guzman, C., Popova, E.Y., Sangadala, S., Huh, W.J., Alexander, M.S., Shelton, J.S..

GOLDENRING, J.R. (2019) Noggin Regulates Programming of Foregut Progenitor Cells and Mis-

expression Leads to Esophageal Atresia. Developmental Cell. Submitted.

246. Jeong, H., Lim, K., Kim, K.H., Cho, Y., Lee, B., Knowles, B.C., Roland, J.T., Zwerner, J.P.,

GOLDENRING, J.R. and Nam, K.T. (2019) Loss of Rab25 promotes the development of skin squamous

cell carcinoma through the dysregulation of integrin trafficking. J. Pathol. In Press.

247. Shimizu, T., Sohn, Y., Choi, E., Petersen, C.P., Prasad, N. and GOLDENRING, J.R.(2019) Alterations in

microRNA expression during initiation of chief cell transdifferentiation. Cell. Molec. Gastroenterol.

Hepatol. Submitted.

248. Choi, E., Vega, P.N., Min, J., Engevik, A.C., Williams, J.A., Yang, Q., Patterson, L.M., Simmons, A.J., Lau,

K.S., Magness, S.T. and GOLDENRING, J.R. (2019) Heterogeneity and dynamics of active Kras-induced

pre-neoplastic lineages from mouse stomach. Nature Commun. Under review.

249. Cao, Z., Singh, B., Li, C., Markham, N.O., Carrington, L.J., Franklin, J.L., Graves-Deal, R., Kennedy, E.J.,

GOLDENRING, J.R. and Coffey, R.J. (2019) PKA-mediated phosphorylation of NKD2 stimulates cell-

surface delivery of TGF-α for EGFR transactivation. Traffic. In Press.

250. Kassaa, E.G., Zlotkin-Rivkin, E., Friedman, G., Ramachandran, R.P., Melamed-Book, N., Weiss, A.M.,

Belenky, M., Reichmann, D., Breuer, W., Lapierre, L.A., GOLDENRING, J.R. and Aroeti, B. (2019)

Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown

of surface polarity PLoS Pathogens. In Press.

251. Tonucci, F.M., Almada, E., Borini-Etichetti, C., Pariani, A., Hidalgo, F., Jose Rico, M., Girardini, J., Favre,

C, GOLDENRING, J.R., Menacho-Marquez, M., and Larocca, M.C. (2019) Identification of a CIP4 PKA

phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis. Cancer Letters.

In Press.

252. Engevik, A.C, Kaji, I., Faust, J.J. Meyer, A.R., Williams, J.A., Tyska, M.J., Wilson, J.M. and

GOLDENRING, J.R. (2019) Loss of Myosin Vb Promotes Apical Bulk Endocytosis in Neonatal

Enterocytes. J. Cell Biol. Revised submission under review.

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253. Wroblewski, L.E., Choi, E. Petersen, C.P., Delgado, A.G., Piazuelo, M.B., Romero-Gallo, J., Lantz, T.L.,

Coffey, R.J. GOLDENRING, J.R., Zemper, A.E. and Peek, R.M., Jr. (2019) Targeted mobilization of

Lrig1+ gastric epithelial stem cell populations by a carcinogenic Helicobacter pylori type IV secretion

system. Proc. Natl. Acad. Sci., USA. Submitted.

GOLDENRING: Page 37

BOOK CHAPTERS ,REVIEWSAND OPINION PIECES

1. DeLorenzo, R. J., Gonzalez, B., GOLDENRING, R. J., Bowling, A. and Jacobson, R. (1983) Calcium-

calmodulin tubulin kinase system and its role in mediating the calcium signal in brain. Prog. Brain Res. 56:

256-286.

2. DeLorenzo, R. J. and GOLDENRING, J. R. (1984) Calmodulin in the nervous system. In Brain Receptor

Methodologies. Marangos, R. J., Campbell, I. C. and Cohen, R. M., eds.). pp. 191-207.

3. Vallano, M. L., GOLDENRING, J. R.. Lasher, R. S. and DeLorenzo, R. J. (1986) Association of

calcium/calmodulin-dependent kinase with cytoskeletal preparations: Phosphorylation of tubulin,

neurofilament, and microtubule- associated proteins. Ann. N. Y. Acad. Sci. 466:357-374.

4 Yu, R. K., GOLDENRING, J. R. and DeLorenzo, R. J. (1985) Effects of gangliosides on rat membrane

protein phosphorylation. In Cellular and Pathological Aspects of Glycoconjugates Metabolism. (Dreyfus,

H., ed.). INSERM 1984. 126:335-354.

5. Vallano, M. L., GOLDENRING, J. R. and DeLorenzo, R. J. (1985) Calcium and calmodulin-dependent

protein kinase: Role in memory. In Mechanisms of Conditioning and Neuronal Plasticity. (Alkon, D. L.

and Woody, C. W., ed.) pp. 383-396.

6. Vallano, M. L., GOLDENRING, J. R., Lasher, R. S. and DeLorenzo, R. J. (1985) Calcium/calmodulin-

dependent kinase II and cytoskeletal function. In Microtubules and Microtubule Inhibitors 1985. (De

Brabander, M. and De Mey, J., eds). pp. 161-170.

7. GOLDENRING, J. R., Vallano, M. L., Lasher, R. S., Ueda, T., and DeLorenzo, R. J. (1986) Association of

calmodulin-dependent kinase II and its substrate proteins with the neuronal cytoskeleton. Prog. Brain Res.

69:341-354.

8. Yu, R. K., GOLDENRING, J. R., Kim, J. Y. and DeLorenzo, R. J. (1986) Gangliosides as differential

modulators of membrane-bound protein kinase activities. Fidia Research Series. 6:95-104.

9. Modlin, I. M., Bilchik, A. J., Nilsson, O. and GOLDENRING, J. R. (1990) Enterochromaffin-like cell

tumor induction in Mastomys by insurmountable H2 receptor blockade. Research and Clinical Forums.

12:59-73.

10. Modlin, I. M., Esterline, W., Kim, H. and GOLDENRING, J. R. (1991) Enterochromaffin-like cells and

gastric argyrophil carcinoidosis. Acta Oncologica. 30:493-498.

11 Modlin, I.M., Kim, H., Bilchik, A. J., Nilsson, O., Esterline, W. J. and GOLDENRING, J. R. (1992)

Pathobiology of enterochromaffin-like tumor induction in mastomys. In The Stomach as an Endocrine

Organ. Eds. R. Hakanson and F. Sundler. In Press.

12. GOLDENRING, J. R., Tang, L. H. and Modlin, I. M. (1993) Low molecular mass GTP-binding proteins

in parietal cells: candidate modulators of parietal cell membrane regulation. Yale J. Biol. Med. 65:597-

605.

13. Modlin, I.M., GOLDENRING, J.R. and Hunt, R. (1993) Aspects of the theoretical basis and clinical

relevance of low acid states. Am. J. Gastroenterol. 89:308-318.

GOLDENRING: Page 38

14. GOLDENRING, J.R. (1995) Rab25. In Guidebook to the small GTPases. (Huber, L., Zerial, M. and

Tooze, J., eds). pp. 372-373.

15. Coffey, R. J., Romano, M. and GOLDENRING, J.R. (1995) Roles for Transforming growth factor-a in the

stomach. J. Clin. Gastroenterol. 21:S36-S39.

16. GOLDENRING, J.R. and Modlin, I.M. (1995) A practical approach to cloning strategies. In Clinical Gene

Analysis and Manipulation. (Ed: J. Jankowski and J. Polak). Cambridge Univ. Press. pp. 270-288.

17. GOLDENRING, J.R. and Nomura, S. (2008) Insights into the Development of Pre-neoplastic Metaplasia:

SPEM and oxyntic atrophy. Amer. J. Physiol, GI Liv. 291:G999-1004.

18. Weis, V.G. and GOLDENIRNG, J.R. (2009) Current Understanding of SPEM and its Standing in the

Preneoplastic Process. Gastric Cancer. 12:189-97.

19. GOLDENRING, J.R. and Nam, K.T. (2010) Oxyntic atrophy, metaplasia and gastric cancer. Prog. Mol.

Biol. Transl. Sci. 96:117-31.

20. GOLDENRING, J.R. and Nam, K.T. (2011) Rab25 as a tumour suppressor in colon carcinogenesis. Br. J.

Cancer. 104:33-6.

21. GOLDENRING, J.R., Nam, K.T. and Mills, J.C. (2011) The origin of pre-neoplastic metaplasia in the

stomach: Chief cells emerge from the Mist. Exp. Cell Res. 317:2759-64.

22. GOLDENRING, J.R. (2013) A central role for vesicle trafficking in epithelial neoplasia:

Intracellular highways to carcinogenesis. Nature Rev. Cancer. 13:813-20.

23. GOLDENRING, J.R. (2015) Recycling Endosomes. Curr Opin Cell Biol. 25:117-122.

24. GOLDENRING, JR. (2015) Referential Obfuscation: Contemplations on the Ethics of Impact. Cell Mol

Gastroenterol Hepatol. 2015 1(4):346-347.

25. GOLDENRING, JR. (2016) What Ever Happened to the Scientific Conversation? Cell Mol Gastroenterol

Hepatol. 2(3):251-252.

26. Petersen, C.P., Mills, J.C. and GOLDENRING, J.R. (2016) Murine Models of Gastric Corpus Preneoplasia.

Cell. Mol. Gastroenterol. Hepatol. 3:11-26.

27. Engevik, A.C. and GOLDENRING, J.R. (2017) Trafficking Ion Transporters to the Apical Membrane of

Polarized Intestinal Enterocytes. Cold Spring Harb Perspect Biol. In Press.

28. Mills JC and GOLDENRING, JR. (2017) Metaplasia in the Stomach Arises From Gastric Chief Cells.

Cell Mol Gastroenterol Hepatol. 4:85-88.

29. GOLDENRING, JR. (2017) The AGA/Funderburg Award in Gastric Cancer: Twenty-five Years of

Advances in Gastric Cancer Research. Gastroenterology. 152:1262-1266.

30. Meyer, A.R. and GOLDENRING, J.R. (2018) Injury, repair, inflammation and metaplasia in the stomach. J.

Physiol. 596(17):3861-3867.

31. GOLDENRING, J. R. (2018) Pyloric metaplasia, pseudopyloric metaplasia, ulcer-associated cell lineage

and spasmolytic polypeptide-expressing metaplasia: reparative lineages in the gastrointestinal mucosa. J.

Pathology. 245(2):132-137.

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32. Thiagarajah, J.R., Kamin, D.S., Acra, S., Goldsmith, J.D., Roland, J.T., Lencer, W.I., Muise, A.M.,

GOLDENRING, J.R., Avitzur, Y.A. and Martin, M.G. (2108) Advances in Evaluation of Chronic Diarrhea

in Infants. Gastroenterology. 154(8):2045-2059.

33. GOLDENRING, J.R. (2019) Membrane trafficking decisions regulate primary cilium formation. Trends

Cell Biol. In Press.

Documents

James Richard Goldenring MD, PhD · 2019-08-06 · Final position: Professor and Chief of Surgery, University of Rejkavik, Iceland. Deceased 2009 Masato Funasaka, MD 1990-1991 Present