January 2013

C14:C14:

Microdosimetry in nuclear medicine:Microdosimetry in nuclear medicine:emerging importance of Auger-electronemerging importance of Auger-electron

datadata

Alan NicholsUniversity of Surrey, UK

& Manipal University, India

January 2013

Cancer Therapy with Auger Electrons: Are We Almost There?

A. I. Kassis, J. Nucl. Medicine 44 (2003) 1479-1481

The Problem of Auger Emitters for Radiological Protection

D. Bingham et al., Radiation Protection Dosimetry 92 (2000)

219-228

Radiotoxicity of Iodine-125 and Other Auger-electron-emitting

Radionuclides: Background to Therapy

S. Adelstein et al., Cancer Biother. Radiopharm. 18 (2003) 301-306

The Electron Spectrum from the Atomic De-excitation of 131Xe

A. Kovalik et al., J. Electron Spectrosc. Relat. Phenom. 95 (1998)

232-254

Auger electrons and dosimetry

January 2013

Immediate and future:

22-26 August 2011, IAEA Headquarters, Vienna, Austria

Intermediate-term Nuclear Data Needs for Medical Applications: Cross Sections and

Decay DataA.L. Nichols, S.M. Qaim and R. Capote Noy

IAEA report INDC(NDS)-0596, September 2011

January 2013

Radionuclide

Requirements Comments

67Ga, 111InAuger electrons may become an issue

Both 67Ga and 111In finding increased application in internal radiotherapy

71GeAuger electrons may become an issue

77BrAuger electrons may become an issue

99Tcm Auger-electron (Ee < 25 keV) and other low-energy electron (Ee < 1 keV) data for microdosimetry

Regularly used for diagnosis, but also increased application in therapeutics

103PdAuger electrons

January 2013

Radionuclide

Requirements Comments

123IAuger electrons Regularly used for diagnosis,

but also increased application in therapeutics

140NdAuger electrons may become an issue

Auger and EC decay; in-vivo generator (140Pr)

178TaAuger electrons may become an issue

Auger and EC decay; in-vivo generator (178W)

193Ptm, 195Ptm Auger electrons may become an issue

Large number of Auger electrons emitted

197HgAuger electrons may become an issue

January 2013

over to Filip and Tibor → C20