-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
1/17
Less Until None:
A Planfor a Worldwithout T1D
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
2/17
2
LESS UNTIL NONE
2
JDRFs Vision for the Future
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
3/17
3
Mission: Less Until None
DangerLESS
ComplexityLESS
InvasiveLESS
BurdenLESS
UNTIL NONE
LESS UNTIL NONE
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
4/17
4
Therapies CureDelivery of Continuous
Therapeutic Improvements
Side-Effects
Complications
Patient Burden
Glycemic ControlSafety
Normal PhysiologyRestored
Better Safety, Fewer Side-Effects, Less Exposure to
Complications
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
5/17
5
$ $$$ $$$$$$
DiscoveryResearch
ClinicalDevelopment
RegulatoryDelivery
to Patients
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
6/17
6
DiscoveryResearch
ClinicalDevelopment
RegulatoryDelivery
to Patients
Investment
Investment
$ $$$ $$$$$$
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
7/177
Near Term Medium Term Long Term
Complications
Diabetic EyeDisease
Insulin Pumps
Infusion
Artificial Pancreas
Low GlucoseSuspend
Complications
PredictiveDiagnosis
Artificial Pancreas
Treat-to-Range
Prevention
SecondaryPrevention
Artificial Pancreas
Treat-to-Target
Artificial Pancreas
Multihormone
Encapsulation
Implantable Islets
Control
GlucoseResponsive Insulin
Prevention
Primary: Vaccine
Complications
ComprehensivePrevention Therapy
Regeneration
This timeline is based on clinical delivery goals of identified
therapies and will be updated as progress is achieved
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
8/178
Artificial PancreasAutomated technologies to helpmaintain better
control of blood-glucose levels
Integrated smart technology toautomate routine elements of
insulinmanagement
FDA released final guidance onpathway for commercialization
of
devices
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
9/179
Glucose Responsive Insulin(GRI)
Form of insulin that activated whenblood-glucose levels start to
rise
Simplifies life for and improves overallblood-glucose
controls
JDRF competition underway toaccelerate progress on GRI
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
10/1710
Encapsulation
Easily implantable Beta cells or isletssurrounded by a
protectiveshield/capsule
Able to sense glucose levels andproduce insulin as needed
Hidden from the immune system tosustain normal function
Eliminating the need for
immunosuppressive drug therapy
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
11/1711
Regeneration
Ability to create new insulin producingcells destroyed by
autoimmune attack
Creating abundant supply of Beta cells
through stem cells and regeneration
Immune therapy for suspected
triggers including viruses
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
12/1712
Secondary Prevention
Preserve beta cell function in thesenewly diagnosed
individuals
Approaches include:
Reducing inflammation
Boosting beta cell survival
Suppressing the autoimmune attack
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
13/1713
Primary Prevention
Prevent the autoimmune attack onbeta cells before it starts
Approaches include:
Viral vaccines
Beta Cell Autoantigen Vaccines
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
14/1714
Funding Scaleand Scope
IndustryInfluence
R&DExpertise
GovernmentAdvocacy
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
15/1715
Funding Scaleand Scope
R&DExpertise
IndustryInfluence
GovernmentAdvocacy
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
16/1716
More = LessT1DFunding $$$ Funding $$$Funding
Funding
FundingFunding
Funding
$$$LESS UNTIL NONEFundingFunding
-
7/30/2019 JDRF, Less Until None: A Plan for a World without
T1D
17/17
Thank you!
