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Jefferies London Healthcare Conference KRKA is one of the leading generic pharmaceutical companies with 65 years of experience in the industry. 21 st November 2019

Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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Page 1: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

Jefferies London Healthcare

Conference KRKA is one of the leading generic

pharmaceutical companies

with 65 years of experience in the industry.

21st November 2019

Page 2: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

www.krka.biz 2

History and Development Committed to Growth with In-House Knowledge and Dedicated to R&D

Growth Phase (1985–ongoing)

Development

Phase

1954–1984

In-licensed products Own products

Current: 3% Current: 97%

Growth on the basis of

numerous in-licensed

products from leading US,

EU and Japanese

originators

Construction of the first API

production plant and

production site for solid

dosage forms

Bridge to Eastern Europe

FDA registration for

production of antibiotics

First thirty years Continuous investments

Establishment of subsidiaries and

representative offices abroad

Accelerated development of own

branded generic medicines and

cooperation with leading international

pharmaceutical companies

Top-ranked in Central, Eastern

and South-Eastern Europe, and

penetrating Western European

markets

Modern Krka (new markets and therapeutic classes)

Expansion of marketing and sales network to

Western European markets by acquiring TAD

Pharma in Germany

Fixed-dose combinations, unique strengths,

unconventional FDFs and new therapeutic classes

(including biosimilars)

Entry into the Chinese market through

establishment of a joint venture – Ningbo Krka

Menovo – with a local partner

2001: 21% 2001: 79%

1984: 85% 1984: 15%

Page 3: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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0

1.000

2.000

3.000

4.000

5.000

6.000

7.000

8.000

9.000

10.000

11.000 Generics/Biosimilars/OTC sales in

million USD in 2018

World Generic Market

Source: Adopted from Generics Bulletin, July 2019.

19th

3

Page 4: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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0

1.000

2.000

3.000

4.000

5.000

Teva

Novart

is

Myla

n

Sta

da

San

ofi

Serv

ier

KR

KA

Auro

bin

do

Zentiva

Fre

se

niu

s

Me

rck K

GaA

Inta

s

Ric

hte

r

Pfizer

GS

K

Sun

Polp

harm

a

No

vo

Torr

en

t

Baye

r

Me

nari

ni

European Generic Market

Source: Morgan Stanley, IMS Health,

IQVIA

4

Ranking by 2018 generic sales

($ MM)

Countries include UK, Russia, Spain, Turkey, Switzerland, Romania, Sweden, Slovakia,

Slovenia, Germany, France, Italy, Poland, Netherlands, Austria, Belgium, Portugal,

Hungary, Greece, Czech Republic, Finland, Ireland, Bulgaria, Norway, Croatia. Richter was

added afterwards.

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www.krka.biz 5

Well-Diversified Activities Present in More than 70 Markets Across Europe and Central Asia

Each day 50 million patients use Krka medicines.

28 subsidiaries and 20 representative

offices

Manufacturing sites in Slovenia,

Croatia, Poland, Russia and

Germany

6 sales regions and more than 70 markets

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Marketing and sales

6

Vertically Integrated Model Advantageous and Effective Business Model

Developing APIs, pharmaceutical forms and analytical methods

Following patient and client requirements

Producing APIs

Producing pharmaceutical forms

Packaging, warehousing, distribution

Monitoring patient and client satisfaction

Quality management and quality control at all stages

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0

2

4

6

8

10

12

14

16

0

200

400

600

800

1.000

1.200

1.400

1.600

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019*

€ m

illi

on

Stable Sales Development

Sales revenue Pieces manufactured (billion)

Compound Annual Growth Rate (2009–2019) 6.5%

7

* Estimate

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6.4%

13.4%

31.2% 22.4%

23.2%

3.4%

Krka Group Sales by Regions Growth in All Regions and Most Markets

Jan–Sept 2019: €1,087.6 million

East Europe

€339.7 million

(+€52.1 million or

+18%)

West Europe

€243.1 million

(+€33.1 million or

+16%)

Slovenia

€69.9 million

(+€3.2 million or +5%)

South-East Europe

€145.6 million

(+€13.3 million or

+10%)

Central Europe

€252.0 million

(+€12.4 million or +5%)

(Growth compared to Jan–Sept 2018)

Krka Group sales of products and

services amounted to €1,087.6

million, up €118.7 million or 12%

compared to the same period last

year.

94% of overall sales of products and

services in the Krka Group were

generated on foreign markets.

The highest absolute sales growth

(by €52.1 million) as well as the

highest relative sales growth (by

18%) was recorded in Region East

Europe.

Krka's leading sales region is

Region East Europe, which

accounted for 31.2% of overall sales.

Overseas Markets

€37.3 million

(+€4.7 million or

+14%)

8

Page 9: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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Krka Group Sales by Product

and Service Groups

(Growth compared to Jan–Sept 2018)

Krka's most important

group of products in

terms of sales value

remain prescription

pharmaceuticals.

With prescription

pharmaceuticals, we

achieved the highest

absolute sales growth

(by €112.0 million) and

the highest relative

sales growth (by 14%).

All product and service

groups recorded an

increase in sales.

84.1%

8.4%

4.7%

2.8%

Non-prescription products

€91.7 million

(+€4.4 million or +5%)

Prescription

pharmaceuticals

€914,9 million

(+€112.0 million or

+14%)

Animal health products

€51.1 million

(+€0.7 million or +1%)

Health resorts and tourist

services

€29.9 million

(+€1.6 million or +6%)

9

Jan–Sept 2019: €1,087.6 million

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0 25 50 75 100 12510

Leading Products Diversified Product Portfolio

Krka’s

Brand

Generic

Name

Therapeutic

Group

1 VALSACOR valsartan Cardiovascular

2 PRENESSA perindopril Cardiovascular

3 LORISTA losartan Cardiovascular

4 ATORIS atorvastatin Cardiovascular

5 NOLPAZA pantoprazole Alimentary Tract

and Metabolism

6 ROSWERA rosuvastatin Cardiovascular

7 EMANERA esomeprazole Alimentary Tract

and Metabolism

8 ENAP enalapril Cardiovascular

9 ZYLLT clopidogrel Cardiovascular

10 DORETA tramadol Analgesic

Jan-Sept 2019 Sales in € million

Page 11: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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R&D spending in € million

170 products in pipeline

700 scientists in

R&D

Innovative generic manufacturer (10% of sales allocated to R&D)

First generic company in Europe to introduce various fixed-dose

combinations

First to offer unique strengths on global pharma markets

Medicines available in variety of unconventional dosage forms

Medicines clinically proven and made in EU

23 MAs for new products in

2018

13 MAs for new products in

Jan–Sept 2019

Target: launching of 20+ new

products per year

Committed to Product Development

0

50

100

150

2018

Jan–S

ept

2018

Jan–S

ept

2019

V m

ilijo

nih

11

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Ravalsyo, Ravalsya,

Valsaros

rosuvastatin/valsartan

Krka was the first to offer unique strengths on the global pharma market:

rosuvastatin atorvastatin tramadol/paracetamol

Atorcombo, Atoris Combi

amlodipine/atorvastatin

Rosmela

rosuvastatin/amlodipine

Please note that some products may not be available in all markets.

Krka’s fixed-dose combinations (FDCs) of antihypertensives and statins

allow for simultaneous treatment of two major risk factors for cardiovascular disease

(hypertension and hyperlipidemia) with a single tablet and ensure better patient compliance.

Krka's New Treatment Options Trailblazing to Accommodate Patient Needs

Innovative

generic

manufacturer

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www.krka.biz 13

Krka was the first generic manufacturer in the global pharma market to

offer the triple FDC of perindopril, indapamide and amlodipine.

Above 70 FDCs of different antihypertensives in various strengths

Co-Perineva,

Prenewel perindopril/indapamide

Telmista H, HD telmisartan/hydrochlorothiazide

Canocombi,

Candecor H, HD candesartan/hydrochlorothiazide

Valsaden, Valsacombi,

Valsacor H, HD valsartan/hydrochlorothiazide

Co-Dalneva, Co-Dalnessa,

Amlewel, Tonanda perindopril/indapamide/amlodipine

Dalneva, Dalnessa,

Tonarssa perindopril/amlodipine

Elyrno enalapril/lercanidipine

Niperten Combi,

BisoDipin bisoprolol/amlodipine

Valodip, Wamlox,

Amlo-Valsacor valsartan/amlodipine

Krka was the first generic manufacturer in Europe to introduce perindopril/amlodipine,

enalapril/lercanidipine, bisoprolol/amlodipine and many other FDCs.

Please note that some products may not be available in all markets.

Krka's New Treatment Options Trailblazing to Accommodate Patient Needs

Page 14: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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• Diabetes continues to be a promising segment for innovative generic Krka products.

Example: Krka was the first manufacturer in Europe to market 90 mg gliclazide

prolonged-release tablets, which permit dose adjustment in patients with type-2

diabetes, and is among Europe’s leading generic manufacturers of gliclazide

prolonged-release tablets.

• Proprietary capacities for oncology medicines in Croatia (EU). Already at the end

of May 2017, we started transferring technologies and production of the first

oncology medicines to the dedicated plant. In the future, oncology products will be

supplemented with new molecules in parenteral and oral forms.

• As to similar biological medicines, focus is placed on evaluating and entry into

projects for medicinal products for the treatment of diabetes and autoimmune

diseases. Products will be developed in strategic cooperation with specialist partner

companies. The role of Krka will be to provide know-how in the area of quality,

clinical testing of efficacy and safety, preparing expert and regulatory documents,

and marketing authorisations.

14

Krka's New Treatment Options Trailblazing to Accommodate Patient Needs

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Research and Development

In the first nine months of 2019, we obtained marketing authorisations for 13 new products in 30 dosage

forms and strenghts:

antiviral Atazanavir Krka (atazanavir) for the treatment of HIV infections;

Sidarso/Silbesan (silodosin) indicated for the treatment of symptoms of an enlarged prostate;

Tadusta intended for treatment of moderate to severe symptoms of benign prostatic hyperplasia;

cinacalcet for regulating levels of parathyroid hormone, calcium, and phosphorus in the body. It is used

for the treatment of secondary hyperparathyroidism;

a new triple combination of perindopril, amlodipine and rosuvastatin;

nebivolol is used for the treatment of hypertension in adults;

Dasatinib Krka is used for to treat Philadelphia chromosome-positive (Ph+) acute lymphoblastic

leukemia (ALL);

Paracetamol Krka 1000 is indicated for the symptomatic treatment of mild to moderate pain and fever;

non-prescription product Vitamin D3 Krka is indicated for prevention of vitamin D deficiency;

non-prescription product KontrDiar is used for treating acute diarrhoea if it is presumed to be of

bacterial origin and is without complications;

non-prescription product Herbion Ivy (ivy leaf dry extract) lozenges, our new cough and cold product;

animal health product Awazom (amoxicillin) is indicated for the treatment of bacterial infections;

animal health product Milprazon/Milgusto/Mektix/Milpragold/Amcofen Chewable for treatment of

mixed infections in cats.

15

Page 16: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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Investments

In the first nine months of 2019, the Krka Group allocated €81.1 million to investments.

In October, Krka's key investment for the purposes of development and quality assurance in the following years, the

€55.6 million product development and quality control facility, Razvojno-kontrolni center 4 (RKC 4), was opened at the

production site in Novo mesto.

In October 2017, Krka started building a multipurpose warehouse to ensure additional storage rooms for incoming materials

and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The

entire investment is estimated at €36 million.

In order to meet the increasing demand and manufacture of new products, Krka is purchasing additional technological

equipment for Notol 2 plant. In 2019, this investment will total €16 million. When the plant is fully equipped, it will be able to

operate at its planned volume, i.e. 5 billion tablets per year.

In progress are preparations for the construction of a new hazardous materials warehouse in Krško. The new building will

store raw materials for chemical and pharmaceutical production. The construction of the €8.2 million building will be finished in

July 2020.

In February 2019, the EU introduced new rules regarding the protection of public health by preventing the entry of falsified

medicinal products into the pharmaceutical supply chain. The Directive introduces obligatory safety features on the outer

packaging of medicines, which prevent falsified medicines from reaching patients. In accordance with these requirements, we

upgraded the technological equipment and manufacturing procedures on many levels. Over the last three years, we

allocated approximately €20 million for the new equipment and technology. Safety measures required by Russian legislation as

of 2020 are also included in this investment.

The Krka-Rus plant, north-west of Moscow, is one of the key investments in Krka's subsidiaries. We are designing additional

manufacturing and laboratory capacities, which will be important for the future business development in Russia. The investment

is estimated at €33 million and will increase manufacturing capacities to 3 billion tablets per year.

At the end of 2017, we established a joint venture Ningbo Krka Menovo with a local partner Menovo in the city of Ningbo,

China. In 2018 we obtained a GMP certificate for leased production facilities. Commercial manufacture of the first product

intended for markets outside China began at the end of 2018. At the same time, we filed all registration documents required to

sell the product in China. In 2019, we will file registration documents for another five MAs for our products in China. 16

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€ thousand

Jan–Sept

2019

Share

(%)

Jan–Sept

2018

Share

(%)

Index

2019/18

Revenue 1,090,721 100.0 971,570 100.0 112

Costs of goods sold 474,558 43.5 418,684 43.1 113

Gross profit 616,163 56.5 552,886 56.9 111

Other operating income 8,199 0.8 7,627 0.8 107

Selling and distribution expenses 261,423 24.0 244,223 25.1 107

R&D expenses 110,839 10.2 95,144 9.8 116

General and administrative expenses 60,520 5.5 57,325 5.9 106

Operating profit 191,580 17.6 163,821 16.9 117

Net financial result 9,961 0.9 -20,832 -2.1

Profit before tax 201,541 18.5 120,570 14.7 141

Income tax 29,611 2.7 22,228 2.3 133

Net profit 171,930 15.8 120,761 12.4 142

Basic earnings per share (in €) 5.50 3.77 146

17

Consolidated Income Statement

of the Krka Group

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Consolidated Statement Of Financial Position

of the Krka Group

€ thousand 30 Sept 2019

Share

(%) 31 Dec 2018

Share

(%)

Index

2019/18

ASSETS 2,129,863 100.0 1,985,069 100.0 107

Non-current assets 1,042,790 49.0 1,010,811 50.9 103

Current assets 1,087,073 51.0 974,258 49.1 112

Thereof:

- Inventories 408,341 19.2 365,149 18.4 112

- Trade receivables 424,172 19.9 438,291 22.1 97

EQUITY AND LIABILITIES 2,129,863 100.0 1,985,069 100.0 107

Equity 1,614,316 75.8 1,540,270 77.6 105

Non-current liabilities 153,600 7.2 123,058 6.2 125

Current liabilities 361,947 17.0 321,741 16.2 112

18

Page 19: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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Krka Group Operating Results

amounts in EUR thousand Jan–Sept

2019

Jan–Sept 2018

EBIT 191,580 163,821

- EBIT margin 17.6% 16.9%

EBITDA 274,233 246,434

- EBITDA margin 25.1% 25.4%

Net profit 171,930 120,761

- Profit margin 15.8% 12.4%

Return on equity (ROE) – annualised 14.5% 10.8%

Return on assets (ROA) – annualised 11.1% 8.4%

19

Page 20: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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-15%

-10%

-5%

0%

5%

10%

15%

20%

25%

30%

EBITDAmargin

Net margin ROE ROA Dividend yield Dividendgrowth

Five-year average

Krka Gedeon Richter Stada Pharma Industry

Strong Long-Term Results In the last five years, Krka outperformed its peers.

Sources: Annual reports. Reuters stock-screener for dividend yield and growth as at 29 March 2019.

20

Page 21: Jefferies London Healthcare Conference · and finished products. The entire transport system and warehouse are expected to become operational in January 2020. The entire investment

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Shareholder Structure

Ten largest shareholders as at 13 November 2019

*fiduciary account

As at 13 November 2019, Krka had 48,910 shareholders.

Shareholder

Shares in

equity (%)

Kapitalska družba, d. d. 10.65

Slovenski državni holding, d. d. 9.00

Republic of Slovenia 7.21

OTP banka, d. d.* 4.70

Addiko Bank d. d.* 3.65

Clearstream Banking SA* 2.76

Unicredit Bank Austria AG* 1.86

Luka Koper d. d. 1.32

Zavarovalnica Triglav, d. d. 1.18

Smallcap World Fund Inc. 1.02

Total 43.35

39.8% 39.7% 39.2% 39.2% 38.8%

8.2% 8.1% 7.7% 7.7% 7.7%

16.2% 16.2% 16.2% 16.2% 16.2%

11.0% 11.0% 11.0% 11.0% 11.0%

1.0% 1.5% 2.1% 2.7% 3.4%

23.8% 23.5% 23.8% 23.2% 22.9%

31 Dec 2015 31 Dec 2016 31 Dec 2017 31 Dec 2018 13 Nov 2019

International investorsTreasury sharesKAD and PPS fundsSDH and Republic of SloveniaSlovenian investment funds and companiesIndividual Slovenian investors

21

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2019 and 2020 Guidelines

Plan adopted by the Management and Supervisory Boards

on 20 November 2019.

22

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2019 Guidelines

The Management Board updates the guidelines for the full 2019 business

year.

The 2019 plan projects:

• sales at €1.430 billion (+4%*);

• net profit at over €200 million (+16%*);

• we intend to allocate €114 million to investment projects, primarily to

increase and upgrade production facilities and the infrastructure;

• 10% of our revenue is allocated to research and development.

23

*compared to initial 2019 guidelines (sales €1.375 million and net profit €173 million)

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Guidelines for Krka′s 2020 performance Management Committed to Growth

The 2020 plan projects:

• sales at €1,520 million (+6%);

• net profit at over €210 million;

• CAPEX at €134 million.

The Management Board remains committed to pursuing

stable dividend policy and intends to allocate at least 50% of

net profit for dividends considering also financial needs,

investments and acquisitions.

The 2020 business plan is based on the Krka Group development

strategy for the period 2020–2024, which is based on the

expectations, estimates and forecasts, and other information

available to the Management Board. The management believes that

expectations are reasonable. If the operating conditions deviate

significantly more than expected in 2020, the operating results may

also deviate from the projections.

24

Sales in € million

1.266 1.331 1.430 1.520

0

400

800

1.200

1.600

2017

2018

2019

E

2020

F

Net income in € million

153 174 200 210

050

100150200250

2017

2018

2019

E

2020

F

2019=estimated, 2020=planed

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2020–2024 Strategy

Krka updates its Strategy biennially.

Strategy adopted by the Management and Supervisory Boards

on 20 November 2019.

25

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Germany

(83 million citizens)

€12.3 billion

+2.3%

among top 10 Gx

Russia

(149 million citizens)

€10.3 billion

+7.2%

3rd foreign

Slovenia

(domestic mkt.)

EUR 0.3 billion

+4.2%

1st overall

China

(1,385 million citizens)

€114.4 billion

+10.6%

established a joint-venture

Industry Trends Solid growth expected in Krka′s generic markets in the next three to five years

26 Source: Worldwide Generic Drug Market, and Krka‘s research.

Poland

(38 million citizens)

€5.7 billion

+9.5%

4th foreign

Ukraine

(42 million citizens)

€1.9 billion

+10.5%

among mkt. leaders

Hungary

(10 million citizens)

€1.3 billion

+4.5%

2nd foreign

Romania

(20 million citizens)

€1.6 billion

+7.4%

1st foreign

Czech r.

(11 million citizens)

€1.1 billion

+7.4%

3rd foreign

Slovakia

(6 million citizens)

€1.0 billion

+4.2%

3rd overall

Croatia

(4 million citizens)

€0.9 billion

+6.9%

2nd foreign

Uzbekistan

(33 million citizens)

€0.6 billion

+15.4%

among mkt. leaders

In the next five years, generic markets

are expected to grow at:

- 5% worldwide;

- 6% Europe;

- 9% Asia and Latin America;

- 1% North America;

- 8–10% MENA.

Key drivers:

- increase in standard of living;

- population growth;

- higher availability of medicines;

- new & niche products (mature

markets);

- life expectancy increase;

- increase of medicine use per capita.

Krka is among

generic market

leaders in many

important and

growing markets.

Market

(population)

mkt. value (2022)

mkt. growth (2022)

Krka‘s position

LEGEND

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From 2020 to 2024, patents for original products worth a total of

$159 billion at originator prices will expire: this is approximately a

quarter less than over the past five years.

The cost of discovering a new medicine has increased to $2.2 billion

per medicine, almost double from $1.2 billion in 2010, while sales of

new original products are decreasing in terms of value. Ability to

manage existing portfolio is thus becoming more important for the

industry as a whole.

Originators continue to extend the life cycle of products by changing

the existing products, by introducing new pharmaceutical forms, by

providing additional concentrations of active ingredients, and by

ensuring additional indications and advanced delivery systems.

Vertical integration allows for better management of development and

production stages, and thus more successful product lifecycle

management.

Industry Trends Fewer patents expiring in the next five years

put a greater emphasis on life-cycle management

27

Having always emphasized new

launches as well as managing the

life-cycle of an existing portfolio,

Krka is well positioned to benefit

from existing and new products in

the next five years due to key

advantages in the fields of:

NEW LAUNCHES

- Krka′s strong in-house R&D and

regulatory teams;

- good track-record of first-to-file and

first-to-market;

- Krka′s R&D, API and FDF vertical

integration.

LIFE-CYCLE OF EXISTING PRODUCTS

- Krka′s recognition and experience in

new fixed dosages, unique delivery

systems, additional concentrations;

- strong M&S and brand awareness on

traditional markets;

- vertical integration.

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Many companies are facing challenges in launching new

products after they have already obtained all the necessary

approvals.

Up to 40% of delays are attributed to issues with supplies of

raw materials.

Following a number of product recalls, safety and quality

assurance are becoming decisive competitive advantages.

FMD is also challenging for many producers, causing delays,

and significantly lower output. Hardware and software upgrades

alone have cost those present in the EU market more than

€1 billion.

The Russian Federation has already been preparing to

introduce a similar system to FMD, but with more stringent

requirements.

28

Industry Trends Quality, Compliance and Vertical Integration Becoming Key Advantages

Krka as a vertically integrated company

will benefit from producing APIs and

FDFs in-house, as well as from having a

very strong QA/QC.

Due to fully compliant products, Krka

was able to offset market shortages

following certain product recalls.

Krka was one of the first producers to

fully prepare for FMD and has

established strong in-house teams with

solid know-how. Similar projects are

already under way in Krka for the

Russian Federation.

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Key Strategic Guidelines 2020–2024 Sales, CAPEX, R&D Expenditure, M&A

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Investments to amount to an average of €136 million per year

39% for FDF production;

37% for API and raw materials production;

24% for infrastructure, IT, and other.

Mergers & acquisitions, joint ventures

In addition to organic growth, Krka intends to expand through acquisitions and long-term business

partnerships, including joint ventures, in case of commercially appealing and available projects.

The primary objectives are to acquire new products and new markets.

Sales growth of at least 5% annually on average in terms of volume/value

R&D expenditure up to 10% of sales

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Key Strategic Guidelines 2020–2024 Performance, Margins

Performance objectives

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The projected average EBITDA margin is between 21% and 25%.

The projected ROE is between 9% and 12%.

Stable dividend policy

When determining dividend payout each year, the Group financial needs for investments and

acquisitions will be taken into account, with at least 50% of net profit of the majority owners being

allocated for dividends.

Process efficacy

Production processes to be additionally optimised (organisation, training) to gain as much output

and flexibility from existing production capacities as possible. Similarly also development.

Further digitalisation with new projects (G&A, M&S, laboratories, production, supply chain).

If needed (patent reasons, regulatory restrictions, large-scale products, niche technologies and

also greater cost-effectiveness), an increase in collaboration with outside partners in the field of

development and production.

Krka′s overall cost efficiency to be continued.

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Key Strategic Guidelines 2020–2024 Markets

31

Focus on European markets, Central Asia and China

In traditional markets of EE, CEE and SEE, Krka is one of the leading suppliers of Rx products for

CVS, gastrointestinal and CNS diseases. We plan also to increase sales of painkillers. A strong

M&S team for all mentioned segments in most cases enables Krka to grow faster than market. In

four key markets, due to the localization of production, Krka is recognized as a domestic

manufacturer, which is a particularly significant market advantage in the Russian Federation

(note: Krka-Rus plant to be significantly expanded) .

Key to successful sales in the highly diverse markets of Western Europe are competitiveness and

pharmacies (consultants). Krka will further increase sales through own M&S network and within

own product brands.

Increased focus on China

Increasing the use of modern generic medicines and changes in the regulatory environment in

China. At the beginning of 2018, a joint venture with a majority stake of Krka started operating in

China.

€25 million of CAPEX in 2020.

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Key Strategic Guidelines 2020–2024 Products

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Product portfolio

Strengthening the existing, golden standard product range in key therapeutic areas – CVS, CNS

and medicines for diseases of the alimentary tract and metabolism – while also entering new

therapeutic areas. Entry into biosimilars and complex peptides with partners. Due to the scale and

complexity, a separate team has been set up.

Innovative generic products and product life-cycle management

New innovative generic products will be introduced in key and other therapeutic areas.

Existing product range will be supported by M&S activities and by introducing new combinations,

strengths, forms and delivery systems.

Launching products on selected markets as one of the first generic suppliers

Maintaining the largest possible share of vertically integrated products

Maintaining the largest possible share of new products in overall sales