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John P. Keady, PhD, 2nd PhD (Summer 2016) 8138 Crestridge Rd. Fairfax Station, Virginia 22039

571-606-1291 Home/Work, jkeady@gmu.edu (email) Expertise

I have experience in both experimental and computational biophysics. I have modelled bacteria and its interaction

with acoustical impulses and the effect on growth, designing/performing laboratory experiments (MTT tests,

Trypan blue surface integrity tests, OD measurements) with a focus currently with the DH5-alpha strain of E. coli.

Scientific/Engineering expertise is in experimental physics/mechanical/medical device engineering. Computational

expertise is in high performance scientific modeling and data mining.

Science/Engineering Education

Ph.D. Computational Sciences and Informatics (Biophysics), George Mason University, 2016, (4.0/4.0)

Ph.D. Experimental Physics, The University of Texas, Dallas, Advisor: Dr. Roderick Heelis, 1998

M.S. Physics, Auburn University, Advisor: Dr. Joseph Perez, 1995

B.S. Aerospace and Ocean Engineering, Virginia Tech, 1988

Ph.D. Committees to which I served as a PhD Advisor

2014-Present Virginia Tech, Industrial and Systems Engineering Dept., Ph.D. Com. Mem. for Derick Wang,

2009-2011 Virginia Tech, Industrial and Systems Engineering Dept., Ph.D. Com. Mem. for Kichol Lee

Professional Engineering/Science History

2014-Present: Instructor/(PW Lab Manager) for Experimental Physics 244 and 246, PW Campus Lab Mang.GMU

2013-2014: GRA, Capturing Upstream Turbulence Information by Modeling the Turbulent Generation Region

and Comparison of 0º and 30º Flow and Dispersion CFD Modeling and Macdonald's MUST

Experiment, Dr. Camelli

2012-2013: GTA, Teach Physics Labs 244, 246 and Intro to Computational Sciences

2011-2016: Ph.D. Student Computational Acoustics GMU

2011-2012: Natural Science Adjunct Professor: Strayer University

2010-2011: Acoustic Field Studies with IRDL, Etymotics, and Virginia Tech ISE Dept.

2008-2010: Chief Scientist/Consultant: Hearium LLC

2001-2007: Senior Technology/IP Advisor/ Inventor, BSKB Law Firm, and Canon USA Inc.

1998-2001: Scientist GPS: Geoloc Corporation

Patents and Patent Applications: (65+total, below only Biophysics related)

U.S. Patent No. 8,989,466, SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND

DISSOCIATION BEHAVIOR OF DNA MOLECULES

U.S. Patent No. 8,409,848, SYSTEM AND METHOD FOR RAPID THERMAL CYCLING U.S. Patent No. 8,306,294, SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES U.S. Patent No. 7,593,560, SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES Certifications/Honors/Awards: NASA Graduate Student Research Project Fellowship, Goddard Space Flight Center, 1996-1998 Texas Space Grant Fellowship Award 1996-1998 “The Outstanding Research Award in Physics”, Auburn University, 1995 NASA Graduate Student Research Project Fellowship, Marshall Space Flight Center, 1993-1995Sigma Pi Sigma Physics Honor Society Inductee, 1991

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John P. Keady, PhD, 2nd PhD (est. 2015), MBA, JD 8138 Crestridge Rd. Fairfax Station, Virginia 22039

571-606-1291 Home/Work, jkeady@gmu.edu (email)

TABLE OF CONTENTS

SECTION PAGE I. GENERAL INFORMATION 3

Personal

Education

Certifications

Honors/Awards

Military Experience

Current Teaching Interests

Current Research Interests

Virginia Tech PhD Committee Membership

References II. ACADEMIC EMPLOYMENT/RESEARCH 4

George Mason University

Strayer University

Northern Virginia Community College

NASA GSRP Fellowship, Goddard Space Flight Center

Richland College, Texas

University of Texas, Dallas

NASA GSRP Fellowship, Marshall Space Flight Center

Auburn University III. ENGINEERING/SCIENCE/MANAGEMENT EXPERIENCE 5

Acting CEO and Scientist, Hearing Ergonomics and Acoustic Resources LLC

Chief Scientist, Personics

Scientist, Geoloc IV. INTELLECTUAL PROPERTY CONSULTANT 6

Start-up Intellectual Property Consultant

Chief Intellectual Property Consultant, Personics

Senior Intellectual Property Consultant, Canon U.S.A. Inc.

Partner, Keady, Olds, Maier, Ciccozzi PLLC

Associate Attorney, Birch Stewart Kolasch and Birch V. PUBLICATIONS/PATENTS 7

Publications

Patents/Patent Applications VI. EXTERNALLY FUNDED RESEARCH 26

Due Diligence Study prior to Licensing Negotiations for U.S. Pat. No.

Situation Awareness: Threshold Detection, Innovation Labs-Client

Situation Awareness: Azmuthal Detection, Innovation Labs-Client

Blind Person GPS Navigation, Geoloc-NIH VII. CURRENT RESEARCH 26

Physical Virology/Particle Experiments/Modeling

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I. GENERAL INFORMATION Focus: To continue my biophysics related work and gain further experience in the field in either an academic setting or corporate. Current 2nd PhD Research Interests: My current research uses acoustic waves/pulses of a non lethal amplitude to disrupt bacteria growth and adhesins. The research uses various areas of physics and biology, experimental design (e.g., tunnel system, handheld pulser, bacteria lab protocol and testing). The most recent tests provide evidence of E. coli growth reduction at specific frequencies and amplitudes. Although the initial theory was developed for viruses, proof of concept studies focused on E. coli because of availability. Further tests are ongoing examining the surface leakiness in developing antibiotic resistant experimental strains. The research includes several unique models both in the acoustic forcing function and in the bacterial response function. Current Teaching Interests: I currently am the Experimental Physics Lab Manager at the Prince William George Mason University Campus, teaching introductory university laboratory physics for a select group of post-BS Military pre-med students. I have taught introductory physics lectures at the undergraduate level and introductory computational physics lectures at the undergraduate level. Statics, Dynamics, Thermodynamics, Newtons Laws, etc… Education: PhD Student in Computational Physics and Data Sciences, est. 2015, (4.0/4.0), George Mason Univ. PhD, Physics, 1998, The University of Texas, Dallas, NASA Fellow M.S. Physics, 1995, Auburn University (NASA Fellow) M.S. work in Aerospace Eng. 1988-1991, Virginia Tech B.S. Aerospace Eng., 1988, Virginia Tech M.B.A. Hi-Tech Management, 2006, The University of Maryland College Park J.D. Patent Law, 2001, Columbus School of Law Certifications/Honors/Awards: Virginia State Bar Registration Number 47027 The United States Patent Office Registration Number 56389 History Channel Honorable Mention (top 100 inventors), 2007 and 2006 "Who’s Who in American Universities and Colleges”, 1997 NASA Graduate Student Research Project Fellowship, Goddard Space Flight Center, 1996-1998 Texas Space Grant Fellowship Award 1996-1998 “The Outstanding Research Award in Physics”, Auburn University, 1995 NASA Graduate Student Research Project Fellowship, Marshall Space Flight Center, 1993-1995 Sigma Pi Sigma Physics Honor Society Inductee, 1991 Military Experience: Military Police, Army Reserves, 304th M.P. Co., 1985-1993 Virginia Tech PhD Committee Membership: ISE PhD Committee external member for Derick Wang, current 2014 . ISE PhD Committee external member for Kichol Lee who graduated from the ISE Department in May, 2011. (A patent application was filed with this student, based on his dissertation, through VTIP). ISE PhD informal external advisor for Kristen Talcott who graduated from the ISE Department in December, 2011. (I provided access to human subject and equipment funds from a corporate-funded research contract to my small company, Innovation Labs, to support this student’s dissertation. In the process, and based on my physics and consumer product background, I served as an external advisor to this student, though I came into the process too late to serve formally on her dissertation committee, as she already had 5 members.) References:

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Dr. Donna Fox, Associate Dean, College of Science, GMU, dfox1@gmu.edu, 703-993-8797 Dr. John G. Casali, Grado Professor, Industrial and Systems Eng., Virginia Tech, jcasali@vt.edu, 540-231-5073 Gary Hoshizaki, Director of IP, Orthosensor Inc., ghoshizaki@orthosensor.com,480-586-5376 Dr. Fernando E. Camelli, Assoc. Prof. Physics, George Mason Univ., fcamelli@gmu.edu, 703-993-4073

II. ACADEMIC EMPLOYMENT/RESEARCH

George Mason University: 2011-present Prince William Campus Experimental Physics Lab Manager, design and choose physics/biophysics labs for academic year, design and build lab experiment if needed, order equipment if needed, set up lab description, teach one lab section, grade and lecture. Optics, Statics, Dynamics, Thermodynamics, Newtons Laws, etc… I also have taught PHYS 244 and 246 Labs: Sophomore Level Physics Lab with emphasis on topics of classical and modern physics of particular importance to science majors. Principles of mechanics, energy, momentum, fluids, and harmonic motion. I also have taught CDS 101: Introduction to Computational and Data Sciences, Introduction to the scientific method and how data sciences and computational sciences contribute to the scientific method. Students learn algorithmic methods of data sciences and computational sciences. I also have taught CDS 130: Computing for Scientist, Introduction to Computational Modeling using Matlab programming, and methods of computational sciences. PhD Research 2013-present: Developed pathogen disruption theory to disrupt pathogen adhesions using acoustic pulses to render them sterile. Designed/built proof of concept verification experiments (bacteria OD studies, two anechoic tunnels, water and air, 50+ ft) on known property particles and derived/coded verification computational models that predict disruption parameters (pulse width, pulse frequency, pulse amplitude, exposure times). Dr. Keady built the entire experimental setup from scratch from two large anechoic pipe tunnels, test tube sample chambers, fabricated the samples, calibration system, wrote the CFD code, analysis software, and has written proposals for continuing funding to carry forward with additional pathogens (influenza and VEE). Strayer University: Adjunct Professor; Jan. 2011- Jan. 2012, SCI110, (4 hours/week), Introduction to Physical Sciences introduces the student to basic concepts from the physical sciences such as motion, force, energy, heat, electricity, magnetism and the atomic theory of matter. Discusses the scientific principles that underlie everyday phenomena, modern technologies and planetary processes. Examines how the various branches of science, such as physics, chemistry, geology, meteorology, astronomy, relate to each other. Lab portion of the course reinforces basic concepts. Northern Virginia Community College: Adjunct Professor: 2001-2003, PHY 201 and 202, College Physics 1 and 2, Teaches fundamental principles of physics. Covers mechanics, thermodynamics, wave phenomena, electricity, optics, magnetism, and selected topics in modern physics. Lecture 3 hours. Laboratory: 3 hours. Total 6 hours per week. NASA GSRP Fellowship, Goddard Space Flight Center: 1996-1998: Satellite Data Analysis coupled with Mathematical Theory: Utilizing plasma physics theory to develop a relationship that can distinguish between Magnetospheric and Ionospheric energy coupling mechanisms, either field from plasma waves and plasma currents. Using satellite electric and magnetic field measurements to determine the relationships between spatial structure in the magnetic field perturbations and the electric field in the high latitude ionosphere. Electric and Magnetic fields can have dual contributions in the Ionosphere, from current and waves. In practice, waves and currents may exist simultaneously and waves may undergo multiple reflections between the magnetosphere and the ionosphere that reduce the clarity with which the relative field contributions can be determined. The study provided a mathematical framework and satellite data verification, to distinguish field contributions from currents and waves, and determine energy coupling between the

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Magnetosphere and Ionosphere, aiding in the development of Space Weather models. This work was conducted as a GSRP NASA Fellow in consultation with Dr. J. Slavin at Goddard Space Flight Center and with Dr. R. Heelis at the University of Texas at Dallas. Richland College, Texas: Astronomy Adjunct Professor: 1996-1997, PHYS 1411, Fundamentals of Astronomy (4). This course concerns fundamental aspects of the solar system and the historical development of astronomical ideas. Included are studies of the celestial sphere and motions of the earth, the moon, planets, and other minor bodies. The origin and evolution of the solar system are also covered. The laboratory includes outdoor viewing sessions and study of celestial motions, elementary navigation, constellation identification, and telescope construction. University of Texas, Dallas: GTA: 1995-1996: PHYS 1301 (PHYS 1301) College Physics I (3 semester hours) Algebra and trigonometry based basic physics. Topics include mechanics, heat and thermodynamics. PHYS 1302 (PHYS 1302) College Physics II (3 semester hours). Continuation of PHYS 1301. Topics include electricity and magnetism and optics NASA GSRP Fellowship, Marshall Space Flight Center: 1993-1995: Space Instrument Design coupled with Deconvolution Theory: Designed and developed electrostatic lens corrective systems for use in a NH rocket experiment, designed several neutral atom imaging sensors, developed the interpretive spline software for use in deconvolving the LENA space satellite images. This work was conducted as a GSRP NASA Fellow in consultation with T.E. Moore at NASA Marshall Space Flight Center and Dr. Perez at Auburn University. Auburn University: GTA: 1991-1993: PHYS 1500 GENERAL PHYSICS I (4). LEC. 3, LAB. 4. Pr., MATH 1130. Science Core. Introduction to Newton's Laws, gravitation and cosmology, concept of conservation laws, solids and fluids, thermodynamics. PHYS 1510 GENERAL PHYSICS II (4). LEC. 3, LAB. 4. Pr., PHYS 1500. Science Core. Electricity and magnetism, AC circuits, waves nuclear physics, radioactivity and particle physics.

III. ENGINEERING/SCIENCE/MANAGEMENT EXPERIENCE

Acting CEO/Engineer/Scientist, HEAR LLC/Innovation Labs LLC: 2010-present: I act as a consultant scientist to various companies such as Bose and Etymotics, manage projects, manage innovation development, perform scientific exploratory experiments, manage innovation protection, negotiate with business leaders in licensing and due diligence studies of innovation. Seek and negotiate research funding. Designed, built, and tested small medically related devices from scratch using several various curing polymers. Senior Scientist, Personics: 2007-2009: Inventor of inflation technology, an inventor on 30+ patents for Personics Holdings Inc. Discoverer and/or Co-Discoverer of Inflation vs. Attenuation, and Occlusion Effect Mitigation. Designed human factors related mechanical systems, built and developed prototypes (design molds (Pro-E), run and operate mold machines for fabrication of medical catheters, balloons). Developed and performed acoustic experiments, built sound isolation tests and chambers, transmission loss experiments, developed and designed earpieces, managed research personnel, ran human subject testing, created pro-E drawings of concepts, developed and managed rapid prototyping of designs. Developed and molded small parts, wired small transducers, designed pneumatic and earpiece couplings. Developed strategy, management, and development of businesses, active in new product development and testing, and new product IP strategy. Coordinated business strategy with marketing, customer feedback, and R&D. Provided strategic leadership for engineering teams. Directed the concept design, simulation, optimization and verification of products developed, including the specification and application of design capture and simulation tools. Led Engineering projects through all product development phases from concept to prototype, to include product documentation, and timely generation of Bills of Materials; worked closely with Marketing throughout the process. Ensured cost control and schedule performance of engineering tasks associated

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with product design and development. Managed design and development activities toward meeting system target cost objectives. Partnered with Marketing for new product development, design reviews, and actively participated in Product Life Cycle planning: contributing to the product definition and specification and prototype testing, and leading the effort to define process recipes and protocols. Scientist, Geoloc: 1998-2001: Develop novel GPS Products/Theories/Navigational Solutions, Kalman Filtering, Experiment Development, Prototype Development, Scientific Software Development, C++, FTP, Serial Port Code, TCP/IP, Database Development, Data Fusion, Ephemeris Software, and Solution of Non-Linear Equations. Developed theory, then software, then hardware prototype of backpack GPS system for use with blind or visually impaired individuals.

IV. INTELLECTUAL PROPERTY CONSULTING (NOTE: Although I have made the Transition back into Science and Technology as a Scientist I do have extensive experience in the Intellectual Property Field at the C-Level and Legal Partner Level as evidenced below)

Intellectual Property Consultant: 2010-Present: Provide Legal Opinion, Patent Portfolio Strategy, Litigation Support, Patent Prosecution Support, and Patent Drafting for Entrepreneurial Start-ups. Chief Intellectual Property Consultant, Personics: 2007- 2010: Managed over formation of over 150+ patent applications. Develop procedures and policies. Evaluate risks to the patent portfolio and advised CEO. Analyze and communicate complex technical and patent issues. Responsible for legal and technical support for patent licensing negotiations. Supervise, train, and mentor patent agents on claims, office actions and the appropriate patent office procedures. Provides technical consultation during the patent application process. Preparation and prosecution, U.S. and foreign patent applications as needed. Provided technical guidance to R&D staff, recommended necessary improvements and corrections to existing specifications, technical analyses, and designs, to insure successful project completion. Worked closely with research and development scientists to achieve patent application filings and agreements satisfying the business and legal objectives. Supervising outside counsel handling prosecution, opinion, and intellectual property matters. Assist business partners in achieving patent strategic objectives; Performing prior art and patentability analyses; Evaluating third party patents; Non-disclosure agreement and licensing agreement activities. Senior Intellectual Property Consultant, Canon U.S.A. Inc. 2005-2007: Reviewed and filed and managed over 100+ patent applications for Canon Inc. in 2006, prosecuted and advised Canon Inc. for over 100 cases, and performed the in person interviews for Canon Inc. cases at the USPTO. Inventor of 2 patent applications DNA analysis devices. Opened Washington DC Metro Area Office of Canon USA Inc’s Intellectual Property Division, Advise President and CTO at Canon Life Sciences Inc. on patent portfolio strategy and creation, patentability opinions, and developed tradesecret policies. Manage IP staff, coordinate outside counsel. Quality control for patent application filing in the United States for Canon Inc. (Japan), Draft patent applications for Canon Development Americas (Irvine CA), Canon Life Sciences Inc., participate in HR meeting concerning IP related issues to employee agreements, participate in licensing discussions, joint development agreements, and NDA construction. Advise President and CTO of best practices with regards to IP. Interact intensively with scientist to develop the most effective IP protection and value, and participate in actively contributing as an inventor. Partner, Keady, Olds, Maier, & Ciccozzi PLLC: (Currently MG-IP Law P.C.) 2003-2005: Form Law firm, advise clients on patent prosecution strategy, draft applications, advise and train patent agents. Establish docketing, procedures, budget, manage patent portfolios, drafting quality control, client counseling, patent strategy, and innovation management.

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Associate Attorney, Birch Stewart Kolasch and Birch: 2001-2003: Draft Patent applications, opinions, responses to office actions and manage portfolio.

V. PUBLICATIONS/PATENTS

Refereed Journal Publications John P. Keady, and Kylene Kehn-Hall, Disruption of growth rate of E. Coli strain DH5α using model predicted

acoustic waves, Journal of Molecular Microbiology and Biotechnology, (being prepared) John P. Keady, and Fernando Camelli, Acoustic attenuation in homogenous and particle doped samples: Part I Experimental description and analysis, Journal of the Acoustical Society of America (JASA) (being prepared) John P. Keady, and Fernando Camelli, Acoustic attenuation in homogenous and particle doped samples: Part II Model description and analysis, Journal of the Acoustical Society of America (JASA) (being prepared) John P. Keady, and Fernando Camelli, Acoustic pulse disruption of particle surfaces: Journal of the Acoustical Society of America (JASA) (being prepared) 1. Casali, J. G., Talcott, K. A., Keady, J. P. and Killion, M. C. Warfighter auditory situation awareness: Locating the shooter with and without hearing protection. Naval Engineers Journal, 2012, 124-1, 149-159. 2. Talcott, K. A., Casali, J. G., Keady, J. P. and Killion, M. C. Azimuthal auditory localization of gunshots in a realistic field environment: Effects of open-ear versus hearing protection-enhancement devices (HPEDS), military vehicle noise, and hearing impairment. International Journal of Audiology, 2012, 51, S20-S30. 3. Keady J.P. and R.A. Heelis, 'Regional, Scale Size and Interplanetary Magnetic Field Variability of Magnetic Field and Ion Drift Structures in the High Latitude Ionosphere', January, JGR 1999 4. Perez J.D., J.P. Keady, T.E. Moore and M.C. Fok, 'Microscale Effects From Global Hot Plasma Imagery', Cross-Scale Coupling in Space Plasmas, Geophysical Monograph 93, 1995 Conference Proceedings and Presentations 1. John P. Keady, P. Huq, W. G. K. Bradbury, P. E. Price, and F. E. Camelli, Capturing Upstream Turbulence Information by Modeling the Turbulent Generation Region and Comparison of 0º and 30º Flow and Dispersion CFD Modeling and Macdonald's MUST Experiment, AMS Conference Feb 2014, Atlanta GA 2. John P. Keady, Pablo Huq, Fernando E. Camelli, Comparison of Flow and Dispersion CFD Modeling and Macdonald’s MUST Experiment, Presentation, Summer 2013 CFD Conference GMU 3. Casali, J. G., Talcott, K., Keady, J. P., and Killion, M. C. Warfighter auditory situation awareness: Locating the shooter with and without hearing protection. Proceedings of the Human Systems Integration Symposium, American Society of Naval Engineers, Vienna, VA, October 25-27, 2011, https://www.navalengineers.org/Proceedings/HSIS2011/Papers/Casali.pdf 4. Clasing, J. E., Casali, J. G., and Keady, J. P. Military hearing protection devices and TCAPS: Can the soldier detect and identify gunshots and other threats? Spectrum, Vol. 29, Supplement 1, and Proceedings (on NHCA website) of the 37th Annual National Hearing Conservation Association Conference, New Orleans, LA, February 23-25, 2012. (extended abstract and powerpoint slide set) 5. Casali, J. G., Keady, J. P., Killion, M.C., and Talcott, K. Military hearing protection-enhancement devices: Protective, but can the soldier locate the shooter? Spectrum, Vol. 28, Supplement 1, and Proceedings (on NHCA website) of the 36th Annual National Hearing Conservation Association Conference, Phoenix, AZ, February 24-26, 2011. (extended abstract and powerpoint slide set)

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6. Keady J.P., “Plasma Boundary Layer Propulsion, AIAA Conference May 2002 Maui Hawaii. Technical Reports 1. Casali, J. G., and Keady, J. P. In-situ threshold detection and identification distances of gunshots,weapons preparation and spoken foreign language under hearing protection/enhancement devices intended for military ground forces applications. (ISE Department Technical Report 201102, IRDL-Audio Lab Number 1/15/11-1-HP), January 15, 2011. (39 pages) (Etymotic Research, Inc. contractor’s report.) 2. Casali, J. G. and Keady, J. P. In-field localization of gunshots in azimuth under two prototype Etymotic and two production AEARO-Peltor hearing protection enhancement devices intended for military ground soldier applications. (ISE Department Technical Report 201003, IRDL-Audio Lab Number 6/30/10-3-HP), June 30, 2010. (52 pages) (Etymotic Research, Inc. contractor’s report.) 3. Casali, J. G., Keady, J. P. and Goldstein, S. G. In-ear canal occlusion effect measurements: A comparison of balloon-based inserts against other commercial inserts and a circumaural device. (ISE Department Technical Report 201001, Audio Lab Number 5/18/10-1-HP), May 18, 2010. (14 pages) 4. Keady J.P., 'The Relationships Between Spatial and Temporal Variations in Magnetic and Electric Fields in the High Latitude Ionosphere', Ph.D. Dissertation, UTD 1998 5. J.P. Keady et al. ‘Space Based Laser Powered Orbital Transfer Vehicle’, NASA Design Project Publication, Virginia Tech, N89-15969, 1988 Patents and Patent Applications (70 +) Only a Sample List Provided Below Earplug and pumping systems Patent number: 9138353 Abstract: An earplug is provided. The earplug includes at least a partially flexible distal end; an inflatable element; and a flexible anti-distal end. The anti-distal end has at least one portion that is deformable. The inflatable element is operatively attached to the distal end by an inflation channel. When the at least one portion is deformed the inflatable element expands to an adjustable pressure. At least one portion of the anti-distal end provides a pressurizing force to maintain the expansion of the inflatable element. Type: Grant Filed: February 16, 2010 Issued: September 22, 2015 Assignee: Personics Holdings, LLC Inventor: John P. Keady Personalized sound management and method Patent number: 9129291 Abstract: Methods for personalized sound management are provided. A module comprising hardware and software is provided to manufacturers to build a device. A process is architected for remote enabling of a device with personalized sound management applications. Consumers select applications for managing their sound environment through purchased and subscription hardware and applications via a web environment. All products developed by manufacturers are tested and certified running the personalized sound management applications. Manufacturers and consumers may both be covered under liability insurance. Users may remotely purchase, update hardware, and add and download subscription based applications through the web environment. Type: Grant Filed: September 15, 2009 Issued: September 8, 2015 Assignee: Personics Holdings, LLC Inventors: Steven Goldstein, John P. Keady, Gary Hoshizaki

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Method and structure for inducing acoustic signals and attenuating acoustic signals Patent number: 9123323 Abstract: At least embodiment is directed to an earpiece comprising a housing; and a field responsive fluid, where the field responsive fluid is in the housing, where the housing is part of the earpiece, and where the earpiece is configured to vary a field to vary an acoustical property of the field responsive fluid. Type: Grant Filed: June 6, 2011 Issued: September 1, 2015 Inventor: John P. Keady Acoustic sealing analysis system Patent number: 9113267 Abstract: A test signal emitted by an earpiece is compared against the acoustic signal to determine if a sealing section of the earpiece is sealed properly. The degree of acoustic sealing is used to adjust the attenuation level of a sealing section of the earpiece or alert the user that the sealing section of the seal status. Type: Grant Filed: October 15, 2013 Issued: August 18, 2015 Assignee: Personics Holdings, Inc. Inventors: John Usher, John P. Keady ACOUSTIC SEALING ANALYSIS SYSTEM Application number: 20150092948 Abstract: A test signal emitted by an earpiece is compared against the acoustic signal to determine if a sealing section of the earpiece is sealed properly. The degree of acoustic sealing is used to adjust the attenuation level of a sealing section of the earpiece or alert the user that the sealing section of the seal status. Type: Application Filed: October 15, 2013 Issued: April 2, 2015 Assignee: Personics Holdings Inc. Inventors: John Usher, John P. Keady Inverted balloon system and inflation management system Patent number: 8992710 Abstract: At least one exemplary embodiment is directed to a pressure management system for an earpiece comprising: a first valve, where the first valve allows air to pass from a first side of the valve to a second side more readily than from the second side to the first side an inflation channel, where the inflation channel has an outer diameter less than 5 mm; a pressure release mechanism; a pump; a stent, where the inflation channel is embedded; and a balloon, where the first valve, the inflation channel, the pressure release mechanism, the pump, and the balloon are operatively connected, where the first valve is positioned so that air from the pump passes through the first valve to inflate the balloon and where the leak rate of the air from the balloon back to the pump is less than 1% by volume per minute and where the pressure release mechanism is configured to release pressure from the balloon to the environment upon actuation, and where the pressure management system is configured to manage the inflation pressure. Type: Grant Filed: October 13, 2009 Issued: March 31, 2015 Assignee: Personics Holdings, LLC. Inventor: John P Keady Systems and methods for monitoring the amplification and dissociation behavior of DNA molecules Patent number: 8989466 Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. Type: Grant

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Filed: November 5, 2012 Issued: March 24, 2015 Assignee: Canon U.S. Life Sciences, Inc. Inventors: Kenton C. Hasson, Gregory A. Dale, John P Keady Method and System for the Visualization of Brain Activity Application number: 20150081225 Abstract: At least one embodiment is directed to a fusion of sensors that generate a data set, where the data set identifies a visual image, where the data set is transmitted to a remote display where the visual image is displayed for a user. Type: Application Filed: June 23, 2014 Issued: March 19, 2015 Inventor: John P. Keady METHOD AND STRUCTURE FOR ACHIEVEING ACOUSTICALLY SPECTRUM TUNABLE EARPIECES, PANELS, AND INSERTS Application number: 20140373854 Abstract: At least one exemplary embodiment is directed to an earpiece that includes a fluid in a reservoir where the composition of the fluid or the pressure of the fluid can be modified to vary the insertion loss value of the earpiece. Type: Application Filed: April 10, 2013 Issued: December 25, 2014 Inventor: John P. Keady Earhealth monitoring system and method I Patent number: 8917880 Abstract: Methods of operating an audio device are provided. A method includes calculating estimated sound pressure levels (SPLs) for drive signals directed to an ear canal receiver (ECR) during a time increment dt; calculating an estimated SPL_Dose during the time increment ?t using the estimated sound pressure levels; and calculating a total SPL_Dose at a time t of the audio device using the estimated SPL_Dose. Type: Grant Filed: March 21, 2012 Issued: December 23, 2014 Assignee: Personics Holdings, LLC. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady Method and device for acoustic sealing and occlusion effect mitigation Patent number: 8848939 Abstract: A system to occlude an ear canal is provided. The system includes an expandable device, a reservoir, a channel coupled between the expandable device and the reservoir, and a pump. The pump expands the expandable device such that a surface of the expandable device contacts an ear canal wall and imparts a force onto the ear canal wall, to produce a tensional strain in the ear canal wall. The strained ear canal wall impedes bodily- propagated sound from entering the ear canal through the ear canal wall, to reduce an occlusion effect by the bodily-propagated sound. Type: Grant Filed: May 24, 2010 Issued: September 30, 2014 Assignee: Personics Holdings, LLC. Inventors: John P. Keady, Gary Hoshizaki ELECTROACTIVE POLYMER SYSTEMS Application number: 20140216480

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Abstract: A device includes a core, a membrane, at least one first electrode coupled to the core, at least one second electrode coupled to the core or the membrane and a collapsible electroactive polymer element. The collapsible polymer element is configured to extend from or extend around at least a portion of the core where the element is in an expanded configuration without application of a voltage and in a collapsed configuration with the application of the voltage or in a collapsed configuration without application of a voltage and in an expanded configuration with the application of the voltage. The voltage is applied via the at least one first electrode and the at least one second electrode. Other embodiments are disclosed. Type: Application Filed: April 7, 2014 Issued: August 7, 2014 Assignee: PERSONICS HOLDINGS, LLC. Inventor: John P. Keady Electroactive polymer systems Patent number: 8718313 Abstract: Electroactive polymer devices are provided. A device includes a membrane and a collapsible electroactive polymer element. The element is in an expanded configuration without voltage application and is in a collapsed configuration with a voltage application. The element is covered by the membrane. Type: Grant Filed: November 10, 2008 Issued: May 6, 2014 Assignee: Personics Holdings, LLC. Inventor: John P. Keady Earpiece sealing system Patent number: 8657064 Abstract: Earphone devices with a sealing section for acoustically sealing the meatus of a human ear are provided. An earphone device includes an inner ear canal speaker and an inner ear canal microphone, each connected to a logic circuit which can include a digital signal processor (DSP). A sealant element is operatively attached to an outer section of the earphone and acoustically seals the meatus of a human ear canal. Type: Grant Filed: June 17, 2008 Issued: February 25, 2014 Assignee: Personics Holdings, Inc. Inventors: Wayne Staab, John P. Keady Acoustic dampening compensation system Patent number: 8625812 Abstract: An acoustic management system configured to compensate for acoustical dampening is provided. The system includes a microphone configured to detect a first acoustic signal from an acoustic environment and a logic circuit. The logic circuit detects an onset of the acoustical dampening between the acoustic environment and the microphone. The logic circuit generates an acoustic damping compensation filter, which is applied to the first acoustic signal to generate a drive signal. Type: Grant Filed: March 7, 2008 Issued: January 7, 2014 Assignee: Personics Holdings, Inc Inventors: Steven W. Goldstein, John Usher, John P. Keady DEVICE AND METHOD TO REDUCE EAR WAX CLOGGING OF ACOUSTIC PORTS, HEARING AID SEALING SYTEM, AND FEEDBACK REDUCTION SYSTEM Application number: 20140003644 Abstract: Devices and methods to reduce ear wax clogging of acoustic ports, hearing aid systems, and feedback reduction systems are provided. A conformal hearing aid includes a hearing aid body, where the hearing aid body

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houses a microphone and a receiver, where the microphone is positioned within the hearing aid body to measure acoustic signals from an ambient environment, and where the receiver is positioned within the hearing aid body to emit acoustic signals toward a tympanic membrane of a user; an expandable element, where the expandable element is operatively connected to the hearing aid body, and where the expandable element is configured to encompass a circumferential portion of the hearing aid body when expanded; and an inflation management system, where the inflation management system is configured to expand the expandable element when actuated. Type: Application Filed: September 4, 2013 Issued: January 2, 2014 Assignee: Personics Holdings Inc. Inventors: John P. Keady, Gary Hoshizaki, John Casali Acoustic sealing analysis system Patent number: 8600067 Abstract: A test signal emitted by an earpiece is compared against the acoustic signal to determine if a sealing section of the earpiece is sealed properly. The degree of acoustic sealing is used to adjust the attenuation level of a sealing section of the earpiece or alert the user of the seal status of the sealing section. Type: Grant Filed: September 9, 2009 Issued: December 3, 2013 Assignee: Personics Holdings Inc. Inventors: John Usher, John P Keady METHOD AND SYSTEM FOR SOUND MONITORING OVER A NETWORK Application number: 20130279703 Abstract: A mobile communication environment (100) can include a mobile device (160) to measure and send sound pressure level data. The mobile device (160) can initiate the collection of audio information responsive to detecting a trigger event. Mobile device (160) can measure or calculate the sound pressure level from the audio information. Metadata including time information and geographic location information can be captured with the collected audio information. Mobile device (160) can send the sound pressure level data and metadata through a wired or wireless communication path to a database (614). Type: Application Filed: June 13, 2013 Issued: October 24, 2013 Inventors: Steven Wayne Goldstein, Marc Boillot, Jason Mclntosh, John P. Keady Device and method to reduce ear wax clogging of acoustic ports, hearing aid sealing system, and feedback reduction system Patent number: 8554350 Abstract: Devices and methods to reduce ear wax clogging of acoustic ports, hearing aid systems, and feedback reduction systems are provided. A conformal hearing aid includes a hearing aid body, where the hearing aid body houses a microphone and a receiver, where the microphone is positioned within the hearing aid body to measure acoustic signals from an ambient environment, and where the receiver is positioned within the hearing aid body to emit acoustic signals toward a tympanic membrane of a user; an expandable element, where the expandable element is operatively connected to the hearing aid body, and where the expandable element is configured to encompass a circumferential portion of the hearing aid body when expanded; and an inflation management system, where the inflation management system is configured to expand the expandable element when actuated. Type: Grant Filed: October 15, 2009 Issued: October 8, 2013 Assignee: Personics Holdings Inc. Inventors: John P. Keady, Gary Hoshizaki, John G. Casali

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SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES Application number: 20130244240 Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. Type: Application Filed: November 5, 2012 Issued: September 19, 2013 Assignee: Canon U.S. Life Sciences, Inc. Inventors: Kenton C. Hasson, Gregory A. Dale, John P. Keady EARHEALTH MONITORING SYSTEM AND METHOD IV Application number: 20130243206 Abstract: A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal microphone (ECM) for producing audio signals as a function of ambient sound received at the ambient sound microphone and a sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECM calculates a total SPL_Dose experienced by the ear at a time t. The total SPL_Dose is calculated by determining SPL_Dose for periods dt as measured at the ECM. The logic circuit may select an action parameter in response to the Total SPL_Dose. Type: Application Filed: May 2, 2013 Issued: September 19, 2013 Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady Method and system for sound monitoring over a network Patent number: 8488799 Abstract: A mobile communication environment (100) can include a mobile device (160) to measure and send sound pressure level data. The mobile device (160) can initiate the collection of audio information responsive to detecting a trigger event. Mobile device (160) can measure or calculate the sound pressure level from the audio information. Metadata including time information and geographic location information can be captured with the collected audio information. Mobile device (160) can send the sound pressure level data and metadata through a wired or wireless communication path to a database (614). Type: Grant Filed: September 8, 2009 Issued: July 16, 2013 Assignee: Personics Holdings Inc. Inventors: Steven Wayne Goldstein, Marc Boillot, Jason McIntosh, John P. Keady METHOD AND STRUCTURE FOR GENERATING AND RECEIVING ACOUSTIC SIGNALS AND ERADICATING VIRAL INFECTIONS Application number: 20130149192 Abstract: At least embodiment is directed to a method of viral eradication which includes: delivering an acoustic wave to a virally infected region; tuning a frequency of the acoustic wave to a resonance frequency of a target virus in the virally infected region; and applying the acoustic wave to the virally infected region for a period of time necessary to eradicate at least 25% of the target virus per cubic mm of the virally infected region. Type: Application Filed: September 10, 2012 Issued: June 13, 2013 Inventor: John P. Keady Earhealth monitoring system and method IV Patent number: 8462956 Abstract: A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal microphone (ECM) for producing audio signals as a function of ambient sound received at the ambient sound microphone and a sound signal received from an associated

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personal audio device. A logic circuit is operatively associated with the ASM and ECM calculates a total SPL_Dose experienced by the ear at a time t. The total SPL_Dose is calculated by determining SPL_Dose for periods ?t as measured at the ECM. The logic circuit may select an action parameter in response to the Total SPL_Dose. Type: Grant Filed: October 31, 2007 Issued: June 11, 2013 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady Ambient situation awareness system and method for vehicles Patent number: 8319620 Abstract: Methods and devices for situation awareness facilitation for a vehicle driver are provided. A method includes receiving a first acoustic signal from outside a vehicle that the driver is in and converting the first acoustic signal into a first acoustic electronic signal; sending the first acoustic electronic signal to a processor; matching the first acoustic electronic signal by the processor to stored reference electronic signals; and sending an acoustic message associated with a matched reference electronic signal to a speaker in the cab of the vehicle. Type: Grant Filed: June 18, 2009 Issued: November 27, 2012 Assignee: Personics Holdings Inc. Inventors: John Usher, John P Keady Occlusion effect mitigation and sound isolation device for orifice inserted systems Patent number: 8312960 Abstract: Methods and devices for sound isolation are provided. A sound isolation device includes an expandable element and an insertion element. The expandable element is operatively attached to the insertion element. The expandable element includes an expanding medium, where the pressure of the expanding medium is varied to vary a sound isolation across the expandable element. Type: Grant Filed: June 26, 2009 Issued: November 20, 2012 Assignee: Personics Holdings Inc. Inventor: John P. Keady Systems and methods for monitoring the amplification and dissociation behavior of DNA molecules Patent number: 8306294 Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. Type: Grant Filed: September 2, 2009 Issued: November 6, 2012 Assignee: Canon U.S. Life Sciences, Inc. Inventors: Kenton C. Hasson, Gregory A. Dale, John P. Keady Device and method for radial pressure determination Patent number: 8251925 Abstract: Methods and apparatus for measuring ear canal wall pressure comfort level are provided. An expandable pressure exertion device is inserted into an orifice. The device is expanded inside the orifice in increments of pressure. A threshold level is saved where a user indicates that the pressure exerted against the walls of the orifice is becoming at least one of uncomfortable, painful, and noticeable. Type: Grant Filed: December 31, 2008 Issued: August 28, 2012 Assignee: Personics Holdings Inc.

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Inventors: John P. Keady, Wayne Staab Earguard sealing system II: single-chamber systems Patent number: 8221861 Abstract: Single-chamber coatings are provided. The single-chamber coating includes a first medium, a second medium, and a ridge structure. The first medium covers at least a first portion of the second medium so as to form a chamber. At least one material property of the first medium is different than the second medium. The first medium forms a first wall of the chamber. The first wall is configured to apply a restorative force upon deformation of the chamber. The ridge structure is along a second wall of the chamber and is configured to direct the second medium substantially parallel to a ridge structure plane when the chamber is deformed. The chamber forms at least a portion of a coating. The coating is configured to be attached to an object that is configured to be inserted into an orifice. Type: Grant Filed: May 5, 2008 Issued: July 17, 2012 Assignee: Personics Holdings Inc. Inventor: John P. Keady Earguard sealing system I: multi-chamber systems Patent number: 8221860 Abstract: Multi-chamber coatings are provided. The multi-chamber coating includes a first medium and a second medium. The first medium covers at least a first portion of the second medium so as to form first and second chambers. At least one material property of the first medium is different than the second medium. The first chamber and the second chamber share a wall. The wall is configured to apply a restorative force upon deformation of the first or second chambers. The coating is configured to be attached to an object that is configured to be inserted into an orifice. Type: Grant Filed: May 5, 2008 Issued: July 17, 2012 Assignee: Personics Holdings Inc. Inventor: John P. Keady EARHEALTH MONITORING SYSTEM AND METHOD II Application number: 20120177210 Abstract: Methods of operating an audio device are provided. A method includes measuring sound pressure levels (SPLECM) for acoustic energy received by an ear canal microphone (ECM) during a time increment dt; and calculating a SPL_Dose during the time increment dt using SPLECM. Type: Application Filed: March 20, 2012 Issued: July 12, 2012 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady EARHEALTH MONITORING SYSTEM AND METHOD I Application number: 20120177209 Abstract: Methods of operating an audio device are provided. A method includes calculating estimated sound pressure levels (SPLs) for drive signals directed to an ear canal receiver (ECR) during a time increment dt; calculating an estimated SPL_Dose during the time increment dt using the estimated sound pressure levels; and calculating a total SPL_Dose at a time t of the audio device using the estimated SPL_Dose. Type: Application Filed: March 21, 2012 Issued: July 12, 2012 Assignee: Personics Holding Inc.

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Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady Earhealth monitoring system and method III Patent number: 8208644 Abstract: A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal receiver (ECR) for producing audio signals as a function of ambient sound received at the ambient sound microphone and a sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECR and calculates a total SPL_Dose experienced by the ear for periods ?t. The logic circuit may select an action parameter in response to the Total SPL_Dose. Type: Grant Filed: October 31, 2007 Issued: June 26, 2012 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady Earhealth monitoring system and method II Patent number: 8199919 Abstract: Methods of operating an audio device are provided. A method includes measuring sound pressure levels (SPLECM) for acoustic energy received by an ear canal microphone (ECM) during a time increment dt; and calculating a SPL_Dose during the time increment ?t using SPLECM. Type: Grant Filed: October 30, 2007 Issued: June 12, 2012 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady Earhealth monitoring system and method I Patent number: 8194864 Abstract: Methods of operating an audio device are provided. A method includes calculating estimated sound pressure levels (SPLs) for drive signals directed to an ear canal receiver (ECR) during a time increment ?t; calculating an estimated SPL_Dose during the time increment ?t using the estimated sound pressure levels; and calculating a total SPL_Dose at a time t of the audio device using the estimated SPL_Dose. Type: Grant Filed: October 30, 2007 Issued: June 5, 2012 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady EARPLUG AND PUMPING SYSTEMS Application number: 20120103346 Abstract: At least one exemplary embodiment is directed to an earplug comprising: at last a partially flexible distal end; an inflatable element; and a flexible anti-distal end, where the anti-distal end has at least one portion that is deformable, where the inflatable element is operatively attached to the distal end by an inflation channel, where when the at least one portion is deformed the inflatable element expands to an adjustable pressure, where at least one portion of the anti-distal end provides a pressurizing force to maintain the expansion of the inflatable element. Type: Application Filed: February 16, 2010 Issued: May 3, 2012 Assignee: PERSONICS HOLDINGS INC Inventor: John P. Keady Methods and devices for hearing damage notification and intervention II Patent number: 8170228

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Abstract: Methods of monitoring sound pressure level are provided. A method of monitoring sound pressure level includes: measuring a first sound pressure level in the ear canal; measuring a second sound pressure level out of the ear canal; calculating a first sound pressure level dose using the first sound pressure level, where if the first sound pressure level is below a permissible sound level a recovery function is used to calculate the first sound pressure level dose; and calculating a second sound pressure level dose using the second sound pressure level. Type: Grant Filed: November 20, 2007 Issued: May 1, 2012 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John P. Keady METHOD AND DEVICE FOR ACOUSTIC SEALING AND OCCLUSION EFFECT MITIGATION Application number: 20120101514 Abstract: At least one exemplary embodiment is directed to a system configured to occlude an ear canal. The system comprises a support structure, an expandable device, a housing, a resilient reservoir, and a threaded device. Resilient reservoir resides within housing and is filled with a medium. The threaded device couples to a threaded region of support structure. Threaded device fits in an opening of housing. Rotating threaded device reduces an interior volume of housing thereby transferring the medium from resilient reservoir to expandable device. Threaded device is rotated to displace sufficient medium within resilient reservoir to expand expandable device to occlude the ear canal. Resilient reservoir is passively filled when expandable device is in an un-expanded state. Type: Application Filed: February 16, 2010 Issued: April 26, 2012 Assignee: Personics Holdings Inc Inventors: John P Keady, Gary Hoshizaki Sound pressure level monitoring and notification system Patent number: 8150043 Abstract: Methods of acoustic dose monitoring and acoustic dose systems are provided. An acoustic dose system includes a first device configured to measure sound pressure levels directed to an ear drum and a second device configured to convert the sound pressure levels into a sound pressure level dose. The second device sends a notification signal to a third device if the sound pressure level dose is larger than a threshold value. Type: Grant Filed: January 30, 2008 Issued: April 3, 2012 Assignee: Personics Holdings Inc. Inventors: Steven W. Goldstein, John Usher, John P. Keady Energy responsive conformal device Patent number: 8142870 Abstract: Sealing devices are presented. The sealing device includes a first material and a second material. The first material responds to energy inputs differently than the second material. The first and second material are operatively connected and configured to be inserted into an orifice. Type: Grant Filed: December 9, 2008 Issued: March 27, 2012 Assignee: Personics Holdings Inc. Inventor: John P. Keady METHOD AND STRUCTURE FOR INDUCING ACOUSTIC SIGNALS AND ATTENUATING ACOUSTIC SIGNALS Application number: 20110311079

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Abstract: At least embodiment is directed to an earpiece comprising a housing; and a field responsive fluid, where the field responsive fluid is in the housing, where the housing is part of the earpiece, and where the earpiece is configured to vary a field to vary an acoustical property of the field responsive fluid. Type: Application Filed: June 6, 2011 Issued: December 22, 2011 Inventor: John P. Keady METHOD AND DEVICE FOR ACOUSTIC SEALING AND OCCLUSION EFFECT MITIGATION Application number: 20110235843 Abstract: At least one exemplary embodiment is directed to a system configured to occlude an ear canal. The system comprises a support structure, an expandable device, a housing, a resilient reservoir, and a threaded device. Resilient reservoir resides within housing and is filled with a medium. The threaded device couples to a threaded region of support structure. Threaded device fits in an opening of housing. Rotating threaded device reduces an interior volume of housing thereby transferring the medium from resilient reservoir to expandable device. Threaded device is rotated to displace sufficient medium within resilient reservoir to expand expandable device to occlude the ear canal. Resilient reservoir is passively filled when expandable device is in an un-expanded state. Type: Application Filed: May 24, 2010 Issued: September 29, 2011 Assignee: PERSONICS HOLDINGS INC. Inventors: John P. Keady, Gary Hoshizaki INVERTED BALLOON SYSTEM AND INFLATION MANAGEMENT SYSTEM Application number: 20110085689 Abstract: At least one exemplary embodiment is directed to a pressure management system for an earpiece comprising: a first valve, where the first valve allows air to pass from a first side of the valve to a second side more readily than from the second side to the first side an inflation channel, where the inflation channel has an outer diameter less than 5 mm; a pressure release mechanism; a pump; a stent, where the inflation channel is embedded; and a balloon, where the first valve, the inflation channel, the pressure release mechanism, the pump, and the balloon are operatively connected, where the first valve is positioned so that air from the pump passes through the first valve to inflate the balloon and where the leak rate of the air from the balloon back to the pump is less than 1% by volume per minute and where the pressure release mechanism is configured to release pressure from the balloon to the environment upon actuation, and where the pressure management system is configured to manage the inflation pressure. Type: Application Filed: October 13, 2009 Issued: April 14, 2011 Assignee: PERSONICS HOLDINGS INC. Inventor: John P. Keady Acoustic Sensor Application number: 20110028839 Abstract: At least one exemplary embodiment is directed to an acoustic sensor, that can be used to identify various fluids as well as concentrations of compounds dissolved in fluids. Type: Application Filed: August 2, 2010 Issued: February 3, 2011 Inventor: John P. Keady METHOD OF MODIFYING AUDIO CONTENT Application number: 20100241256

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Abstract: At least one exemplary embodiment is directed to a method of generating a Personalized Audio Content (PAC) comprising: selecting Audio Content (AC) to personalize; selecting an Earprint; and generating a PAC using the Earprint to modify the AC. Type: Application Filed: December 7, 2009 Issued: September 23, 2010 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven Goldstein, John Usher, John P. Keady Device and Method to reduce Ear Wax Clogging of Acoustic Ports, Hearing Aid Sealing System, and Feedback Reduction System Application number: 20100177918 Abstract: At least one exemplary embodiment that is directed to a conformal hearing aid comprising: a hearing aid body, where the hearing aid body houses a microphone and a receiver, where the microphone is positioned within the hearing aid body to measure acoustic signals from an ambient environment, and where the receiver is positioned within the hearing aid body to emit acoustic signals toward a tympanic membrane of a user; an expandable element, where the expandable element is operatively connected to the hearing aid body, and where the expandable element is configured to encompass a circumferential portion of the hearing aid body when expanded; and an inflation management system, where the inflation management system is configured to expand the expandable element when actuated. Type: Application Filed: October 15, 2009 Issued: July 15, 2010 Assignee: PERSONICS HOLDINGS INC. Inventors: John P. Keady, Gary Hoshizaki, John G. Casali METHOD AND SYSTEM FOR SOUND MONITORING OVER A NETWORK Application number: 20100142725 Abstract: A mobile communication (100) can include a mobile device (160) to measure and send sound pressure level data. The Mobile device (160) can initiate the collection of audio information responsive to detecting a trigger event. Mobile device (160) can measure or calculate the sound pressure level from the audio information. Metadata including time information and geographic location information can be captured with the collected audio information. Mobile device (160) can send the sound pressure level data and metadata through wired or wireless communication path to a database (614). Type: Application Filed: September 8, 2009 Issued: June 10, 2010 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven Wayne Goldstein, Marc Boillot, Jason McIntosh, John P. Keady Sound Library and Method Application number: 20100142715 Abstract: At least one exemplary embodiment is directed to a website configured to collect sound signatures from around the world and beyond. A communication device automatically stores acoustic information received by a microphone of the communication device. The acoustic information is analyzed for a trigger event. The trigger event stores the acoustic information, attaches metadata, creates a Gaussian Mixture Model, and measures sound pressure level. The communication device automatically sends the sound signature to a database when a communication path is opened to communication device. Each sound signature has associated metadata including a time stamp and geocode. Automatically collecting sounds using a communication device adapted for the process enables a database that captures sounds globally on a continuous basis. Type: Application Filed: September 15, 2009 Issued: June 10, 2010 Assignee: PERSONICS HOLDINGS INC.

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Inventors: Steven Goldstein, John P. Keady, Gary Hoshizaki, Marc Boillot Personalized Sound Management and Method Application number: 20100076793 Abstract: At least one exemplary embodiment is directed to implementing personalized sound management applications. A module comprising hardware and software is provided to manufacturers to build a device. A process is architected for remote enabling of a device with personalized sound management applications. Consumers select applications for managing their sound environment through purchased and subscription hardware and applications via a web environment. All products developed by manufacturers are tested and certified running the personalized sound management applications. Manufacturers and consumers may both be covered under for liability insurance. Users may remotely purchase may update, purchase hardware, add and download subscription based applications, and replace consumable through the web environment. Type: Application Filed: September 15, 2009 Issued: March 25, 2010 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven Goldstein, John P. Keady, Gary Hoshizaki ACOUSTIC SEALING ANALYSIS SYSTEM Application number: 20100074451 Abstract: A test signal emitted by an earpiece is compared against the acoustic signal to determine if a sealing section of the earpiece is sealed properly. The degree of acoustic sealing is used to adjust the attenuation level of a sealing section of the earpiece or alert the user that the sealing section of the seal status. Type: Application Filed: September 9, 2009 Issued: March 25, 2010 Assignee: PERSONICS HOLDINGS INC. Inventors: John Usher, John P. Keady OCCLUSION EFFECT MITIGATION AND SOUND ISOLATION DEVICE FOR ORIFICE INSERTED SYSTEMS Application number: 20100012420 Abstract: At least one exemplary embodiment is directed to a sound isolation device comprising: an expandable element; and an insertion element, where the expandable element is operatively attached to the insertion element, where the expandable element includes an expanding medium, where the pressure of the expanding medium is varied to vary sound isolation across the expandable element. Type: Application Filed: June 26, 2009 Issued: January 21, 2010 Assignee: Personics Holdings Inc. Inventor: John P. Keady PRESSURE REGULATING SYSTEMS FOR EXPANDABLE INSERTION DEVICES Application number: 20100002897 Abstract: At least one exemplary embodiment is directed to an earpiece comprising: an ambient sound microphone (ASM); an ear canal microphone (ECM); an ear canal receiver (ECR); and an inflatable sealing section, where the sealing section includes at least one pressure valve, where the at least one pressure valve opens when the pressure in the sealing section is greater than an ambient pressure. Type: Application Filed: July 6, 2009 Issued: January 7, 2010 Assignee: PERSONICS HOLDINGS INC. Inventor: John P. Keady

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SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES Application number: 20090324037 Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. Type: Application Filed: September 2, 2009 Issued: December 31, 2009 Assignee: Canon U.S. Life Sciences, Inc. Inventors: Kenton C. Hasson, Gregory A. Dale, John P. Keady Systems and methods for monitoring the amplification and dissociation behavior of DNA molecules Patent number: 7593560 Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. Type: Grant Filed: November 29, 2007 Issued: September 22, 2009 Assignee: Canon U.S. Life Sciences, Inc. Inventors: Kenton C. Hasson, Gregory A. Dale, John P. Keady Earpiece Sealing System Application number: 20090214072 Abstract: At least one exemplary embodiment is directed toward an earphone device with a sealing section for acoustically sealing the meatus of a human ear, which includes an inner ear canal speaker; an inner ear canal microphone; connected to a logic circuit which can include a digital signal processor (DSP), where a sealant operatively attached to an outer section of the earphone acoustically seals the meatus of a human ear canal. Type: Application Filed: June 17, 2008 Issued: August 27, 2009 Assignee: PERSONICS HOLDINGS INC. Inventors: Wayne Staab, John P. Keady DEVICE AND METHOD FOR RADIAL PRESSURE DETERMINATION Application number: 20090192407 Abstract: At least one exemplary embodiment is directed to a method of measuring ear canal wall pressure comfort level comprising: inserting an expandable pressure exertion device into an orifice; expanding the device inside the orifice in increments of pressure; and saving a threshold level where a user indicates that the pressure exerted against the walls of the orifice is becoming at least one of uncomfortable, painful, and noticeable. Type: Application Filed: December 31, 2008 Issued: July 30, 2009 Assignee: PERSONICS HOLDINGS INC. Inventors: John P. Keady, Wayne Staab ENERGY RESPONSIVE CONFORMAL DEVICE Application number: 20090155518 Abstract: At least one exemplary embodiment is directed to a sealing device comprising, a first material; and a second material, where the first material responds to energy inputs differently than the second material, and where the first and second material are operatively connected and configured to be inserted into an orifice. Type: Application Filed: December 9, 2008 Issued: June 18, 2009 Assignee: PERSONICS HOLDINGS INC.

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Inventor: John P. Keady ELECTROACTIVE POLYMER SYSTEMS Application number: 20090130423 Abstract: At least one exemplary embodiment is directed to a device that includes a membrane and a collapsible electroactive polymer element, where the element is in an expanded configuration without voltage application and is in a collapsed configuration with a voltage application, where the element is covered by the membrane. Type: Application Filed: November 10, 2008 Issued: May 21, 2009 Assignee: PERSONICS HOLDINGS INC. Inventor: John P. Keady DEVICE AND METHOD FOR REMOTE ACOUSTIC PORTING AND MAGNETIC ACOUSTIC CONNECTION Application number: 20090067661 Abstract: An earpiece device includes a microphone and a speaker having a common acoustic channel to reduce complexity and minimize components in an ear canal region. The earpiece device also includes a logic circuit operatively connected into an earpiece, where the microphone is configured to sample an acoustic signal traveling from either end of an acoustic channel. The earpiece device further includes a selective attenuation mechanism for varying the acoustic energy from one end of the acoustic channel or combining the acoustic energies in a controlled ratio from both ends of the acoustic channel before reaching the microphone. Type: Application Filed: July 21, 2008 Issued: March 12, 2009 Assignee: Personics Holdings Inc. Inventors: John P. Keady, Robert Schulein ELETROFLUID COLLISIONAL ACCELERATOR AND FUSION REACTOR Application number: 20090065714 Abstract: At least one exemplary embodiment is directed toward accelerating charged hydrogenated fluid into collisions of sufficient energy to initiate at least partial fusion of the collisional hydrogenated fluid, where one of the products of the collision is a product including an element higher in the periodic tables than at least one of the colliding fluids, and where, optionally, the at least partial fusion heats a coolant loop which in turn generates electricity. Type: Application Filed: November 30, 2007 Issued: March 12, 2009 Inventor: John P. Keady EARGUARD SEALING SYSTEM II: SINGLE-CHAMBER SYSTEMS Application number: 20080311324 Abstract: At least one exemplary embodiment is directed to a single-chamber coating comprising: a first medium; a second medium; and a ridge structure, where the first medium covers at least a first portion of second medium so as to form a first chamber, where at least one material property of the first medium is different than the second medium, where the first medium forms a first wall the first chamber, where the first wall is configured to apply a restorative force upon deformation of the first chamber, where the ridge structure is along a second wall of the first chamber, where the ridge structure is configured to direct the second medium substantially parallel to the ridge structure plane when the first chamber is deformed, where the first chamber forms at least a portion of a coating, and where the coating is configured to be attached to an object that is configured to be inserted into an orifice. Type: Application Filed: May 5, 2008 Issued: December 18, 2008

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Assignee: PERSONICS HOLDINGS INC. Inventor: John P. Keady EARGUARD SEALING SYSTEM I: MULTI-CHAMBER SYSTEMS Application number: 20080299339 Abstract: At least one exemplary embodiment is directed to a multi-chamber coating comprising: a first medium; and a second medium, where the first medium covers at least a first portion of second medium so as to form a first and second chamber, where at least one material property of the first medium is different than the second medium, where the first chamber and second chamber share a wall, where the wall is configured to apply a restorative force upon deformation of the first or second chamber, where the first and second chamber form at least a portion of a coating, and where the coating is configured to be attached to an object that is configured to be inserted into an orifice. Type: Application Filed: May 5, 2008 Issued: December 4, 2008 Assignee: PERSONICS HOLDINGS INC. Inventor: John P. Keady ACOUSTIC DAMPENING COMPENSATION SYSTEM Application number: 20080219456 Abstract: At least one exemplary embodiment is directed to an acoustic management system configured to compensate for acoustical dampening comprising: a microphone configured to detect a first acoustic signal from an acoustic environment; and a logic circuit, where the logic circuit detects an onset of acoustical dampening between the acoustic environment and the microphone, and where the logic circuit generates an acoustic damping compensation filter, where the acoustic damping compensation filter is applied to the first acoustic signal generating a drive signal. Type: Application Filed: March 7, 2008 Issued: September 11, 2008 Inventors: Steven W. Goldstein, John Usher, John P. Keady EARHEALTH MONITORING SYSTEM AND METHOD I Application number: 20080212787 Abstract: At least one exemplary embodiment is directed to a method of operating an audio device comprising: calculating estimated sound pressure levels for drive signals directed to an ear canal receiver (ECR) during a time increment dt; calculating an estimated SPL_Dose during the time increment dt using the estimated sound pressure levels; and calculating a total SPL_Dose at the time t of the audio device using the estimated SPL_Dose. Type: Application Filed: October 30, 2007 Issued: September 4, 2008 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady

SOUND PRESSURE LEVEL MONITORING AND NOTIFICATION SYSTEM Application number: 20080181442 Abstract: At least one exemplary embodiment is directed to an acoustic Dose system comprising: a first device configured to measure sound pressure levels directed to an ear drum; and a second device configured to convert the sound pressure levels into a sound pressure level dose, where the second device sends a notification signal to a third device if the sound pressure level dose is larger than a threshold value. Type: Application Filed: January 30, 2008 Issued: July 31, 2008 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven W. Goldstein, John Usher, John P. Keady

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METHOD AND DEVICE OF CUSTOMIZING HEADPHONES Application number: 20080178088 Abstract: At least one exemplary embodiment is related to a method of device customization comprising: entering physiological data, where the physiological data is obtained from a visual image loaded by a web based software program; selecting device features using the web based software program; and selecting the device appearance using the web based software program. Type: Application Filed: July 27, 2007 Issued: July 24, 2008 Assignee: Personics Holdings Inc. Inventors: Steven W. GOLDSTEIN, John P. Keady

EARHEALTH MONITORING SYSTEM AND METHOD IV Application number: 20080144842 Abstract: A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal microphone (ECM) for producing audio signals as a function of ambient sound received at the ambient sound microphone and sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECM calculates a total SPL_Dose experienced by the ear at a time t. In one exemplary embodiment, the total SPL_Dose is calculated by determining SPL_Dose for periods dt as measured at the ECM. The logic circuit then may then select an action parameter in response to the Total SPL_Dose. Type: Application Filed: October 31, 2007 Issued: June 19, 2008 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady EARHEALTH MONITORING SYSTEM AND METHOD III Application number: 20080144841

Abstract: A system for monitoring sound pressure levels at the ear includes an ambient sound microphone for receiving ambient sounds and an ear canal microphone for producing audio signals as a function of ambient sound received at the ambient sound microphone and sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECR calculates a total SPL_Dose experienced by the ear at a time t. In one exemplary embodiment the total SPL_Dose is calculated by determining estimated SPL_Dose for periods dt. The logic circuit then may then select an action parameter in response to the Total SPL_Dose. Type: Application Filed: October 31, 2007 Issued: June 19, 2008 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady

EARHEALTH MONITORING SYSTEM AND METHOD II Application number: 20080144840 Abstract: At least one exemplary embodiment is directed to a method of operating an audio device comprising: measuring sound pressure levels (SPLECM) for acoustic energy received by an ear canal microphone (ECM) during a time increment dt; and calculating a SPL_Dose during the time increment dt using SPLECM. Type: Application Filed: October 30, 2007 Issued: June 19, 2008 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven W. Goldstein, John Usher, Brian Fligor, John P. Keady

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SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES Application number: 20080130971 Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. Type: Application Filed: November 29, 2007 Issued: June 5, 2008 Assignee: CANON U.S. LIFE SCIENCES, INC. Inventors: Kenton C. Hasson, Gregory A. Dale, John P. Keady

Methods and Devices for Hearing Damage Notification and Intervention II Application number: 20080130906 Abstract: At least one exemplary embodiment is directed to a method of monitoring sound pressure level comprising: measuring a first sound pressure level in the ear canal; measuring a second sound pressure level out of the ear canal; calculating a first sound pressure level dose using the first sound pressure level, where if the first sound pressure level is below a permissible sound level a recovery function is used to calculate the first sound pressure level dose; and calculating a second sound pressure level dose using the second sound pressure level. Type: Application Filed: November 20, 2007 Issued: June 5, 2008 Assignee: PERSONICS HOLDINGS INC. Inventors: Steven W. Goldstein, John P. Keady Devices and Methods for Automated Mobile BioDiesel Production Application number: 20070240362 Abstract: At least one exemplary embodiment is directed to a device that uses a co-axial oil and methoxide flow to near real time mix the two flows into biodiesel. Type: Application Filed: April 16, 2007 Issued: October 18, 2007 Inventor: John P. Keady

Plasma impulse device Patent number: 7096660 Abstract: A plasma impulse device/method has been developed to provide impulses that can be used for thrust. A field device produces electric and magnetic fields, which E×B drifts a charged portion in the ambient environment, resulting in thrust of the field device. Type: Grant Filed: May 20, 2003 Issued: August 29, 2006 Inventor: John P. Keady Plasma impulse device

Application number: 20040070349 Abstract: A plasma impulse device/method has been developed to provide impulses that can be used for thrust. A field device produces electric and magnetic fields, which E×B drifts a charged portion in the ambient environment, resulting in thrust of the field device. Type: Application Filed: May 20, 2003 Issued: April 15, 2004 Inventor: John P. Keady

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VI: EXTERNALLY FUNDED RESEARCH Bose Research Project: 04/2016-present Project involves evaluating prototype designs for use in military settings. Bose Research Project: 01/2016-04/2016 Project involved human subject testing to evaluate the use of a novel ear tip system for commercialization. Due Diligence Project prior to Licensing Negotiations of U.S. Patent No. 8,550,206: 03/2015 to 08/2015 Project from 03/2015 to 08/2015 to verify research covered by Patent No. 8,550,206, funded by third party interested in exclusively licensing technology, Dr. Keady is co-inventor. Device Design Evaluation and Redesign Recommendations: Usability Testing, Ratings, and Objective Measurement of Detection-Identification: (Note this study was the pioneering study for Military insistence of a standard testing method for current devices) 2010: The research had as its major objective to experimentally determine the effects of 2 currently-deployed military HPE devices (i.e., third generation Combat Arms level-dependent earplug and Peltor Com-Tac II electronic earmuff), as well as a prototype device that draws upon recent advancements in hearing aid technology with electronic adaptations for use in impulsive (e.g., gunfire) noise (Etymotic Research Electronic BlastPlgs, Model EB-15 set in a “Hi” gain position, described later). In accomplishing this major objective, the detection distance and identification threshold task was performed by all subjects in a rural quiet ambient noise. The combination of the three threat conditions with the 3 HPEs and the open ear condition comprised the experiment. Objective dependent measures of detection distance and identification threshold were derived from verbal responses from the subjects as they moved from marked position to marked position, where they stated when they could hear the particular threat being tested. The objective and results of this research project were to compare military available products, their performance, identify weaknesses and areas of possible improvement. Device Design Evaluation and Redesign Alternatives: Usability Testing, Ratings, and Objective Measurement of Localization: (Note this study was the pioneering study for Military insistence of a standard testing method for current devices) 2010: The objective was to evaluate localization of suprathreshold gunshot’s report (from blank ammunition) with one passive and three electronic level-dependent hearing protection enhancement devices (HPEDs), in comparison to the open ear in an in-field test environment with ambient outdoor noise and in heavy truck noise with normal and impaired hearing participants. Methods: Five measures of localization accuracy and response time for eight shooter positions in azimuth were measured for 9 normal hearing and 4 impaired hearing participants. Statistical analysis showed worse accuracy and response time performance with the electronic earmuffs (Peltor Com-Tac II) than with the other tested HPEDs (Etymotic EB 1 and EB 15, and 3M Combat Arms earplug). Performance with all HPEDs was worse than that with the open ear, except on right-left confusions, in which the earmuff stood alone as worst, and in response time, for which the EB 1 was equivalent to the open ear. The result of the project was the comparison of product weaknesses, and identification of needed areas of improvement. Blind Person GPS Navigation, Geoloc-NIH: 1998-2001 1998-2001: Developed the theoretical solution to the GPS position equations so that intentional error in the signal is removed, design and coded the software to test the theory with actual data, built a backpack prototype system, and tested the system in the real world environment. Error in position was reduced from 100m to 5m with a single frequency signal.

VII: CURRENT RESEARCH

Bacterial Resonance Disruption Modeling: 2012-present, this research examines the delivery of acoustic pulses to suspended particles/pathogen to disrupt capsid integrity and outer protein functionality to affect infectivity. Dr. Keady has designed and built the test equipment and is currently writing submission to peer reviewed journals. This project is described in more detail above.