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Article history:

Accepted 26 March 2010

Keywords:

Knee

Forces

a b s t r a c t

Morrison calculated joint forces of 200400% BW (percent of

ntactshaftatedlkingload

2005, 2006, 2007; Mundermann et al., 2008). One year post-

Contents lists available at ScienceDirect

lseBi

Journal of Bio

Journal of Biomechanics 43 (2010) 21642173data during walking and stair climbing, measured in two subjectsE-mail address: ines.kutzner@charite.de (I. Kutzner).body weight) during level walking (Morrison, 1970). Whilst more operatively peak tibial forces were 280% BW (level walking), 290%BW (stair ascending), 330% BW (stair descending) and 264% BW(chair rise). Most data is restricted, however, to total compressiveforces measured in one subject. Complete six component load

0021-9290/$ - see front matter & 2010 Elsevier Ltd. All rights reserved.

doi:10.1016/j.jbiomech.2010.03.046

n Corresponding author. Tel.: +49 30 450 559678; fax: +49 30 450 559980.and static optimization. However, large variations of reportedloading exist. Using gait analysis and a mathematical model,

data measured by instrumented total knee replacements duringactivities of daily living in vivo became available (DLima et al.,tissue structures. The net moment, caused by the external forces,is additionally counterbalanced by the moments exerted bymuscles, soft tissues, contact forces and frictional forces. Muscleand joint contact forces can be analysed using gait data togetherwith musculoskeletal modelling techniques e.g. inverse dynamics

trized implants were developed to measure the joint coforces in vivo. Taylor and co-workers measured loads in theof a distal femoral replacement (Taylor et al., 1998). The estimforces in the knee joint of 220250% BW during level wawere smaller than those determined analytically. Recently,1. Introduction

The knee joint is loaded by external forces (ground reactionforce, masses and acceleration forces of foot and shank). Theirsum is counterbalanced by the forces acting across the joint, i.e.the tibio-femoral contact forces, muscle forces and forces in soft

recently forces of approximately 310% BW were reported using asimilar computational approach (Taylor et al., 2004), other studiescalculated contact forces of up to 710% BW during level walkingand even 800% BW for downhill walking (Costigan et al., 2002;Kuster et al., 1997; Seireg and Arvikar, 1975).

To overcome uncertainties of mathematical models, teleme-as measured in vivo by others. Some of the observed load components were much higher than those

currently applied when testing knee implants.Moments

Telemetry

In vivo

Measurements

Load

ImplantDetailed knowledge about loading of the knee joint is essential for preclinical testing of implants,

validation of musculoskeletal models and biomechanical understanding of the knee joint. The contact

forces and moments acting on the tibial component were therefore measured in 5 subjects in vivo by an

instrumented knee implant during various activities of daily living.

Average peak resultant forces, in percent of body weight, were highest during stair descending

(346% BW), followed by stair ascending (316% BW), level walking (261% BW), one legged stance (259%

BW), knee bending (253% BW), standing up (246% BW), sitting down (225% BW) and two legged stance

(107% BW). Peak shear forces were about 1020 times smaller than the axial force. Resultant forces

acted almost vertically on the tibial plateau even during high exion. Highest moments acted in the

frontal plane with a typical peak to peak range 2.91% BWm (adduction moment) to 1.61% BWm(abduction moment) throughout all activities. Peak exion/extension moments ranged between

0.44% BWm (extension moment) and 3.16% BWm (exion moment). Peak external/internal torqueslay between 1.1% BWm (internal torque) and 0.53% BWm (external torque).

The knee joint is highly loaded during daily life. In general, resultant contact forces during dynamic

activities were lower than the ones predicted by many mathematical models, but lay in a similar range

& 2010 Elsevier Ltd. All rights reserved.Loading of the knee joint during activitive subjects

I. Kutzner a,n, B. Heinlein a,b, F. Graichen a, A. BendeA. Beier d, G. Bergmann a

a Julius Wolff Institute, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 1b ZHAW Zurich University of Applied Science, Biomechanical Engineering, Winterthur, Sc Berlin-Brandenburg Center for Regenerative Therapies, Charite Universitatsmedizind Hellmuth-Ulrici-Kliniken, Klinik fur Endoprothetik, Sommerfeld, Germany

journal homepage: www.ewww.Jof daily living measured in vivo in

,c, A. Rohlmann a, A. Halder d,

Berlin, Germany

zerland

in, Germany

vier.com/locate/jbiomechomech.com

mechanics

in vivo, was only published by Heinlein et al. (Heinlein et al.,2009). Peak axial forces of 208276% BW (level walking) and327352% BW (descending stairs) were reported.

The aim of this study was to examine the tibio-femoral contactforces and moments in the knee joint during daily life in vivoin a more representative cohort of 5 subjects and to examineinter-individual differences. All six load components (3 forces,3 moments) acting on an instrumented tibial tray were measured.

2. Materials and methods

2.1. Instrumented implant

Various forces and moments act across the knee joint, caused by external

forces, active muscles, soft tissue deformations and the contact forces and

moments acting directly between the condyles and the tibial plateau. The

instrumented knee implant measures the 3 contact forces and 3 contact moments,

acting on the tibial component, with a typical error below 2% (Heinlein et al.,

2007). Its design is based on the INNEX FIXUC total knee system (Zimmer GmbH,

Winterthur, Switzerland) with an ultra-congruent tibial insert and a standard

femoral component. From the load-dependent deformations of its stem, which are

component or by both factors and are only a fraction of the total knee moments.

The coordinate system is xed to the tibial tray and not to the instantaneous

Forces in the transverse plane, for example, changed from a

x

Fy

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 21642173 2165axis of the knee joint. Magnitudes of the exion/extension moments around the

knee axis, for example, may differ substantially from the ones acting around the

prosthesis x-axis (Heinlein et al., 2009).

F

Fz

MyMx

Mzmeasured by 6 semi-conductor strain gages (KSP 1-350-E4, Kyowa), the 6 load

components are calculated. All signals are sensed and transmitted by a custom-

made, inductively powered telemetry circuit (Graichen et al., 2007).

2.1.1. Coordinate system and nomenclature

The centre of the coordinate system is xed at the right tibial component on

the extended stem axis at the height of the lowest part of the polyethylene insert

(Fig. 1). Forces and moments measured in left knees were transformed to the right

side. Force components +Fx, +Fy and +Fz act in lateral, anterior and superior

direction on the tibial component. Moments +Mx, +My and +Mz act in the sagittal,

frontal and horizontal plane of the tibial component and turn right around their

respective axes. From the components, the resultant forces F and momentsMwere

calculated.

The moments are termed, according to clinical conventions, after the tibial

rotation they counterbalance. To give an example: if external or muscle forces act

as to abduct the tibia, the moment +My counteracts this rotation. This moment is

termed abduction moment (although it tries to adduct the tibia). In this sense all

moments are named: exion/extension moment +Mx/Mx, abduction/adductionmoment +My/My, external/internal rotation moment +Mz/Mz.

The contact moments can be caused by a distance between the resultant force

and the centre of the coordinate system, by friction between femoral and tibialFig. 1. Coordinate system of the instrumented tibial component.laterally directed force +Fx to a medially directed force Fx. Thissign inversion becomes obvious in Fig. 3 if all large symbols areabove zero and the small symbols are below zero. In the following,all values refer to typical peak loads if not stated otherwise.

3.1.1. Resultant forces F (Fig. 3A)

Smallest peak resultant forces of 107% BW were measuredduring 2LegSt. During SitD the values were about two times higher(225% BW). StUp, KneeB, 1LegSt and LevWalk caused nearly thesame forces (246261% BW). The highest forces acted during AscSt(316% BW) and DesSt (346% BW). The absolute maximum of Ffrom all subjects and trials was 400% BW, measured in K5R duringDesSt. Peak axial forces Fz were of similar magnitude as thestated resultant forces F.

3.1.2. Shear forces Fx and Fy (Fig. 3B and C)

Shear forces in the transverse plane were about 1020 timessmaller than the axial force Fz. In most subjects the largest shearforces Fx and Fy were found during LevWalk, AscSt and DesSt.Medial shear forces (Fx) ranged between 1% and 18% BW,forces in lateral direction (+Fx) between +1% and +16% BW.Highest medial forces were mainly observed in K4R, highestlateral forces mainly in K2L.

Shear forces Fy in posterior direction were highest forLevWalk (26% BW), AscSt (32% BW) and DesSt (34% BW).In K4R, however, high exion activities (SitD, StUp, KneeB) led toindividual posterior forces Fy of 46% BW. Shear forces inanterior direction (+Fy) typically lay between +2% and +18% BW.2.2. Subjects

After obtaining approval of the ethics committee and the subjects informed

consent to participate in the study and have their images published, the prosthesis

was implanted in 4 male and 1 female subjects with osteoarthritis (Table 1).

A medial parapatellar approach was used; the cruciate ligaments were sacriced.

Femoral and tibial component were cemented. The mechanical axis angles

between the tibial axis and an axis connection knee and hip joint centers were

determined by radiographs during two legged stance (Specogna et al., 2007;

Colebatch et al., 2009). No subject had further joint replacements except K2L,

whose contralateral knee had been replaced 6 months previously.

2.3. Activities investigated and data evaluation

Eight most frequent and strenuous activities of daily living were investigated

(Table 2, Fig. 2) and are further named by their abbreviations. Every activity was

repeated 5 to 25 times by each subject. Average time courses of resultant forces

from several trials were calculated using a dynamic time warping procedure

(Wang and Gasser, 1997). During 2LegSt, StUp, SitD and KneeB ground reaction

forces were measured to control an even body weight distribution. KneeB was

performed to self-selected exion angles: K1L (901001), K2L (1001051), K3R(90951), K4R (80851) and K5R (90951).

Ranges of forces and moments during complete loading cycles are stated by

their maximal (and minimal, if applicable) peak values. In different subjects these

peak values may occur at different time points. Peak forces during walking, for

example, can act either during the instants of contralateral toe off (CTO) or prior to

contralateral heel strike (CHS).

Individual forces or moments of each subject refer to the average peak values

from all investigated trials. Typical forces or moments are the averages of the

individual loads from all ve subjects. Absolute maxima/minima refer to the

highest/lowest value from all investigated subjects and trials.

In the following, peak forces are stated in percent of the body weight (%BW),

peak moments in percent body weight times meter (%BWm).

3. Results

3.1. Typical peak loads

During most activities (except static positions), shear forces andmoment components changed their sign during a loading cycle.During 1LegSt, Fy always acted in the posterior direction.

Body weight (kg) 100

Height (cm) 177

22 16 7 11

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 216421732166Time of measurement (months post-operatively) 10

Mechanical axis angle (deg.) preoperative 8 varus

Mechanical axis angle (deg.) postoperative 3 varus

Table 2Activities investigated.

Activity AbbreviationTable 1Subject data.

Subject K1L

Sex Male

Age at implantation (years) 633.1.3. Flexionextension moments Mx (Fig. 4A)

In the sagittal plane high exion moments +Mx (+0.53% to+3.16% BWm), but only small extension moments Mx (0.14%to 0.44% BWm) acted. Flexion moments +Mx were highestduring DesSt (3.16% BWm), followed by AscSt (2.29% BWm),LevWalk (1.92% BWm) and 1LegSt (1.81% BWm). Slightly lowerexion moments occurred during high exion and two-leggedactivities: StUp (1.24% BWm), SitD (1.35% BWm) and KneeB (1.39%BWm). With an absolute maximum of 6.00% BWm the highestexion moment (+Mx) was seen in K3R during DesSt.

3.1.4. Abductionadduction moments My (Fig. 4B)

In the frontal plane, abduction moments +My were highest duringKneeB (1.61% BWm) followed by StUp (1.39% BWm), AscSt (1.26%BWm), DesSt (1.04% BWm), SitD (1.14% BWm) and LevWalk (1.0%BWm).

High adduction moments My were observed duringall activities which include temporary single legged stance.

Two legged stance 2LegSt

Sitting down SitD

Standing up StUp

Knee bend KneeB

One legged stance 1LegSt

Level walking LevWalk

Ascending stairs AscSt

Descending stairs DesSt

Fig. 2. Subject K5R during the investigated activities. Body positions at peak resultantwalking, E: ascending stairs, F: descending stairs8 varus 9 varus 3 varus 11 varus

5 varus 4 varus 5 valgus 1 varus

Trials ConditionsK2L K3R K4R K5R

Male Male Female Male

71 70 63 60

90 92 97 100

171 175 170 175AscSt/DesSt led to moments of 2.58/2.57% BWm. During1LegSt/LevWalk slightly higher values of 2.88/2.91% BWmwere measured. Smaller moments acted during StUp (0.97%BWm), KneeB (0.91% BWm) and SitD (0.77% BWm). With anabsolute maximum of 4.62% BWm, the highest adductionmoment My was observed in K2L during DesSt. As seen for Fythe component My did not change its sign during 1LegSt.Throughout all activities, highest adduction moments (My)were observed in K2L, highest abduction moments (+My) in K4R.

3.1.5. Externalinternal rotation moment Mz (Fig. 4C)

Highest rotation moments acted during LevWalk. Theytypically changed from +0.53% BWm during the early stancephase to 1.1% BWm at late stance. AscSt also caused highinternal rotation moments Mz of 0.92% BWm. For all otheractivities internal rotation moments Mz lay between 0.22%and 0.66% BWm. External rotation moments +Mz were typicallysmaller, and reached values between 0.07% and 0.53% BWm.

5 Equal load distribution

5 Seat height 45 cm, no support at armrest

5 Seat height 45 cm, no support at armrest

5 Self-selected exion angle

5 No or minimal support at ngertip

25 Self-selected comfortable speed on level ground

10 Stair height 20 cm, no support at handrail

10 Stair height 20 cm, no support at handrail

forces; A: one legged stance, B: standing up/sitting down, C: knee bend, D: level

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Fig. 3. Peak forces during investigated activities. Data from 5 subjects. Aresultant force F, Bmedio-lateral force Fx, Cantero-posterior force Fy. Large/smallsymbolsaverage maximum/minimum from several trials of 1 subject (individual forces). Thin linesaverage values from all subjects and trials (typical forces). Thicklinesabsolute maximum/minimum values from all subjects and trials. Peak values of component Fz are nearly identical to those of F.

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 21642173 2167

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Mz

[%B

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]

Fig. 4. Peak moments during investigated activities. Data from 5 subjects. Aexion/extension moment Mx, Babduction/adduction moment My, Cexternal/internalrotation moment Mz. Large/small symbolsaverage maximum/minimum from several trials of 1 subject (individual moments). Thin linesaverage values from allsubjects and trials (typical moments). Thick linesabsolute maximum/minimum values from all subjects and trials.

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 216421732168

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Fx Fy Fz F

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Fx Fy Fz F Fx Fy Fz F

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Fx Fy Fz F

Fig. 5. Load patterns during investigated activities. Upper diagrams forces, lower diagramsmoments. Exemplary trials from K5R. HS: heel strike; CTO: contralateral toeoff; CHS: contralateral heel strike; CSC: contralateral stair contact.

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 21642173 2169

of co-contraction in the models. The impact of co-contractions

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 2164217321703.2. Load patterns

The force- or moment-time courses for each activity weresimilar amongst the subjects. In the following, typical loadcharacteristics are described using exemplary trials from K5R(Fig. 5).

3.2.1. Two/one legged stance (Fig. 5A)

Changing from 2LegSt to 1LegSt led to about 2.5 timesincreased axial forces Fz as well as an increase of the adductionmoment My and exion moment +Mx. Shear forces Fx, Fyremained small during one and two legged stance.

3.2.2. Knee bend, standing up and sitting down (Fig. 5B and C)

During high exion activities, highest peak forces wereobserved at the instant of large exion (KneeB, Fig. 2C), shortlyafter loosing contact with the chair (StUp, Fig. 2B) and prior to theseated position (SitD, Fig. 2B). During high exion especially theabduction moments +My, but also the exion moments +Mx werehigh. These high values of +My indicate a pronounced load shift tothe lateral compartment.

3.2.3. Level walking (Fig. 5D)

Two main force peaks occurred at the instant of contralateraltoe off (CTO) and shortly before contralateral heel strike (CHS)(Fig. 2D). In K1L, K3R, K4R and K5R the second peak at CHS washigher than the rst one; in K2L both were of similar height. Amuch smaller force peak was furthermore seen immediatelybefore heel strike (HS). At CTO small shear forces Fy were actingin posterior and +Fx in lateral directions in most subjects. A shearforce Fx in medial direction was only observed in K4R.

In contrast to the high exion activities and similar to 1LegStand 2LegSt, an adduction moment My acted in the frontal planeduring stance phase, indicating a medial load shift. Flexionmoments +Mx reached their peak values around CTO and CHS.The axial torque changed from initial external rotation moments+Mz at CTO to pronounced internal rotation moments Mz atCHS.

3.2.4. Ascending/descending stairs (Fig. 5E and F)

Peak forces occurred at CTO and during or shortly aftercontralateral stair contact (CSC). In most subjects maximumforces acted around CSC when AscSt (Fig. 2E) and at CTO duringDesSt (Fig. 2F). In the sagittal plane exion moments +Mx actedthroughout the whole stance phase with peak values at CTO andCSC. In the frontal plane, adduction moments My acted betweenCTO and CSC, but abduction moments +My after CSC. The twopeak values of My occurred subsequently to CTO and CSC. Thesigns of My indicate an initially predominant force transfer by themedial compartment and a nal shift to the lateral side. DuringAscSt and DesSt mainly internal rotation moments Mz acted atthe tibia.

3.3. Force directions

Since both shear forces Fx and Fy were small for all activitiesand in all subjects, resultant forces in general acted almostvertically on the tibial plateau (Fig. 6). This was especially the casefor high resultant forces and surprisingly also seen to be the caseduring the high exion activities KneeB, StUp and SitD. Only in K4Rconsiderable shear forces in posterior direction at high exionwere apparent. In the frontal plane only small directiondifferences within subjects and activities were observed. In K2LFx was directed slightly laterally, in K4R slightly medially during

most activities.becomes obvious if a subject looses balance during 1LegSt. Forcesof more than 550% BW were observed on that occasion. During2LegSt the joint force is also higher than required statically.Whereas only about 44% BW would be required to support thebody weight by both legs, additional 60% BW act due to themuscle activities required to maintain equilibrium. In vivo loadmeasurements in combination with gait analyses are underway toimprove the existing models.

During high exion activities (StUp, SitD, KneeB) typical forcesbetween 210% and 260% BW were measured although the body issupported by both knee joints. Lower forces during KneeB in K4Rwith a exion angle of only 80851 indicate that the force leveldepends on the maximum exion. During high exion, mainlyabduction moments +My acted in the frontal plane whereasadduction moments My prevailed during all activities whichinclude temporary single legged stance. Negative My valuesindicate that the contact force is predominantly transferred bythe medial compartment and vice versa.

The limited data of our 5 subjects support the assumption thatabductionadduction moments and knee alignment are related.Highest adduction moments My and thus a more medial loadtransfer were observed in K2L with a varus alignment (Fig. 4).Highest abduction moments +My and thus a more lateral transferwere seen in K4R with a valgus alignment. The varus/valgusalignment may furthermore inuence the medio-lateral shear3.4. Load variations

Load variation within one subject was moderate. The intra-individual range of peak resultant forces F was typically around50% BW during LevWalk (Fig. 7A), AscSt and DesSt. Smaller rangesof about 30% BW were observed during all other activities(Fig. 7C), which implies an overall intra-individual variation ofpeak resultant forces of about 1020%.

Inter-individual variation of F was highest during KneeB(Fig. 7D). Peak values differed between 182% BW (K4R) and300% BW (K1L), reecting the variation of performing thismovement. With variations of about 70% BW, inter-individualvariation was moderate for StUp, SitD and LevWalk (Fig. 7B),smaller differences of about 50% BW were observed during AscSt,DesSt, 1LegSt and 2LegSt.

Even though the peak to peak range of shear forces andmoments were comparable between most subjects, the loadmagnitudes varied considerably (Figs. 4, 5). During most activitiesthe highest medial shear forces Fx, posterior shear forces Fy,extension moments Mx and abduction moments +My weremeasured in K4R. Highest lateral shear forces +Fx, adductionmoments My and external rotation moments +Mz were mostlyfound in K2L. Highest exion moments +Mx were measured inK3R.

4. Discussion

The knee joint is highly loaded during daily life. For mostactivities, resultant forces lay typically in the range 220350% BW.Similar values were reported in other in vivo studies usinginstrumented implants (DLima et al., 2007; 2005; Mundermannet al., 2008; Taylor et al., 1998). Greater discrepancies existbetween the forces actually measured and those obtainedanalytically. Many models overestimate the loads during dynamicactivities. For AscSt axial forces between 425% and 540% BW werecalculated (Morrison, 1969; Taylor et al., 2004), exceeding themeasured values by up to 40%. On the other hand models tend tounderestimate the loading during static activities due to the lackforces Fx. Highest lateral forces +Fx occurred in K2L, highest

One

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K2L K3R K5RK4R

Fig. 6. Force directions during investigated activities. Selected trials from all 5 subjects. For each activity (lines) and subject (columns) the force vectors are displayed in thefrontal (left) and the sagittal (right) plane. Individual peak resultant forces are indicated. Different scales are used.

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 21642173 2171

I. Kutzner et al. / Journal of Biomechanics 43 (2010) 216421732172100

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Intra-individual rangemedial forces Fx in K4R (Fig. 3). No hint to a correlation betweenthe axis alignment and the axial force Fz, as expected by others(Heller et al., 2003), was found in the present cohort.

The data presented here conrm previous ndings (Heinleinet al., 2009) that the international standard protocol for wear testsof tibial inserts underestimates the axial torque Mz. Whereas apeak-to-peak moment of 7 N m is dened in the ISO standard(ISO14243-1, 2002) typical peak-to-peak moments of 15 N mwere now measured, with individual values of up to 19 N m andan absolute range of even 29 N m. The signs of the axial torque andall other load components change within each load cycle duringmost activities. This is detrimental for bone-implant interfacestresses and polyethylene wear and should be considered whentesting knee implants.

The reported data were obtained with a specic implantdesign and cannot be transferred directly to other implants or the

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Fig. 7. Variation of resultant force during level walking and knee bending. Left intra-inbending (C). Thick lineaverage from all trials. Right inter-individual variation betweewas averaged by time warping.100

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nt F

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Inter-individual rangenatural knee. The cruciate ligaments were sacriced andchanged gait patterns are possible. Changes of passive softtissue structures such as the collateral ligaments may alsoinuence the contact loads. The axial force Fz and the resultantforce F will most likely not be affected much by the type of TKR,however. In vivo load measurements in different, posteriorcruciate retaining TKR, indeed resulted in similar values of F(DLima et al., 2007, 2005; Mundermann et al., 2008). Because ofthe ultra-congruent tibial insert of our implant the largestdifferences were expected for the shear forces Fx and Fy.Surprisingly the anterior shear forces +Fy, which were measuredin the cruciate retaining implant (DLima et al., 2007), were also ina similar range as those from our data. This implies that only asmall part of +Fy is transferred trough the remaining cruciateligament. No nal conclusions, however, can be drawn due to thelimited number of subjects.

0 20 40 60 80 1000

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dividual variation between several trials of K5R during level walking (A) and knee

n average curves of 5 subjects during level walking (B) and knee bending (D). Data

The given information is the most comprehensive data set ofin vivo knee joint loading so far. Investigations in more subjectsare currently performed to even broaden this data collection andto deepen the understanding of knee joint biomechanics.

Conict of interest statement

This study was supported by Zimmer GmbH, Winterthur,Switzerland. Except from funding, the sponsor was not involvedin study design, collection, analysis and interpretation of data, oranything related to this manuscript.

Acknowledgments

The authors gratefully acknowledge the voluntary collabora-tion of all subjects and the technical support of Jorn Dymke. Thisstudy was supported by Zimmer GmbH, Switzerland.

References

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I. Kutzner et al. / Journal of Biomechanics 43 (2010) 21642173 2173measured in vivo after total knee arthroplasty. Journal of Arthroplasty 21,255262.Wang, K., Gasser, T., 1997. Alignment of curves by dynamic time warping. TheAnnals of Statistics 25, 168171.DLima, D.D., Patil, S., Steklov, N., Slamin, J.E., Colwell Jr., C.W., 2006. Tibial forces 625632.moments and shear after total knee arthroplasty. Journal of Biomechanics 40,S11S17.

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Loading of the knee joint during activities of daily living measured invivo in five subjectsIntroductionMaterials and methodsInstrumented implantCoordinate system and nomenclature

SubjectsActivities investigated and data evaluation

ResultsTypical peak loadsResultant forces F (Fig.3A)Shear forces Fx and Fy (Fig.3B and C)Flexion-extension moments Mx (Fig.4A)Abduction-adduction moments My (Fig.4B)External-internal rotation moment Mz (Fig.4C)

Load patternsTwo/one legged stance (Fig.5A)Knee bend, standing up and sitting down (Fig.5B and C)Level walking (Fig.5D)Ascending/descending stairs (Fig.5E and F)

Force directionsLoad variations

DiscussionConflict of interest statementAcknowledgmentsReferences