Joint Research (JR) Training Rodent Research and General · PDF fileJoint Research (JR) Training Rodent Research and General JR ... **ICBs expected to take place in Russia starting

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Operations Laboratory

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NASA MSFC Huntsville, Alabama

Joint Research (JR) TrainingRodent Research and General JR

July 2016

Crew Training Coordinators (CTC)Kathy H. Brown and Nancy Horvath

[email protected]@nasa.gov

Approved for Public Release; Distribution is Unlimited

https://ntrs.nasa.gov/search.jsp?R=20160009685 2018-05-18T13:12:19+00:00Z

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Page 2NASA MSFCHuntsville, Alabama

Outline Flight changes for Rodent Research (RR) missions RR Operator training for cosmonauts Protocol affecting I53/54 (52S/53S) Training Proposal for I53/54 Backup slides

RR-5 Tasks Russian Rodent Mission Tasks Other Joint Research Tools Training and Support Payload Rack Training Rodent Research Training Flow Rodent Research Training Objectives Rodent Research Hardware

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Flight Changes for Rodent Missions

Changes in Flight schedules for Rodent Research (RR) RR5 has moved up to SpX-11 (from SpX-12)

Current Launch 2/1/17 – Increment 50/51 Russian Rodent mission and/or JAXA RR (TBD) SpX-12

Current Launch 6/1/17 – Increment 51/52 RR6 or Russian Rodent mission (TBD) SpX-13?

Current Launch Sept 2017 – Increment 52/53/54 All Joint Rodent Research missions beginning with RR5 will involve

special skills and will require operator level training for cosmonauts (as defined on the following slide).

Indications are that Rodent Joint Research is going to continue indefinitely and that the Rodent missions will alternate with each Space X flight between a Joint Research and a Russian Crew Ops missions. Example: SpX-11 is Joint Research; SpX-12 is expected to be a Russian Crew Ops flight; SpX-13 would be Joint Research (TBD); .….

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RR Operator Level training for Cosmonauts The following facility and Rodent Research classes are required for

operators (based on current RR5 & Russian Rodent Mission tasks)*: Animal Consent Briefing** (0.50 Hr.) Animal Care Briefing (0.50 Hr.) Generic Rodent Skills Lab (4.00 Hr.) Rodent Habitat Animal Transfer (1.25 Hr.) Rodent Habitat Familiarization (2.00 Hr.) Rodent Skills 1 (See backup for details) (3.00 Hr.) Rodent Skills 3 (See backup for details) (3.00 Hr.) Rodent Skills 4 (See backup for details) (3.00 Hr.) Rodent JR Increment Skills (3.00 Hr.)

Total Rodent Training 20.25 Hr.*** HRF Rack Familiarization (0.25 Hr.) support class HRF Refrigerated Centrifuge (0.50 Hr.) support class Cold Transfer Skills (1.00 Hr.) support class MSG Facility Familiarization (1.00 Hr.) support class

Total Support classes 2.75 Hr.

*If dissections or other TBD tasks are added, training hours could increase by 8 hours or more. (current tasks are in backup slides)**ICBs expected to take place in Russia starting in July/August 2016 with 51S & 52S cosmonauts***Interpretation time will be added – in general 30% overhead = total of 30 hrs.

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April 2016 ProtocolJR proposed training for 52S & 53S (I53/54) is based on April protocol list of science experiments. We need Energia to send I53/54 Research Program to GCTC to support training preparation in Aug and training start in September 2016.

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Proposed training for I53Joint Research training planned: (hours below do not include interpretation)All cosmonauts will receive payload rack training*. Both Skv & Vgn will have the below red text placeholders in their payload training plan until assignments &/or ICB are completed. GCTC concurrence needed by August 5, to support training start in Sept 2016.

Payload Rack training for cosmonauts has been approved via ITCB, ETRIP, and MPTP to begin with I53/54 (52S). Classes are scheduled in September for Skv & Vgn.

Payload Rack classes, 4.5 hrs. EXPRESS Rack, 1 hr. HRF Rack, .25 hr. HRF Refrigerated Centrifuge, .5 hr. HRF Ultrasound 2, .25 hr. MELFI, .75 hr. MSG, 1 hr. WORF, .75 hr.

Rodent Research (Operator) – 21.25 hrs. Consent Briefing, .5 hrs. ** Care Briefing, .5 hrs. (Sept 2016)

Generic Rodent Skills, 4 hrs. (Sept 2016)

Rodent Skills 1, 3 hrs. (Dec 2016)

Rodent Skills 3, 3 hrs. (May 2017)

Rodent Skills 4, 3 hrs. (May 2017)

Rodent JR Increment Skills, 3 hrs. (June 2017)

Rodent Habitat Animal Transfer, 1.25 hrs. (June)

Rodent Habitat Fam for JR, 2 hrs. (June 2017)

Support classes: Cold Transfer Skills, 1.0 hrs. (June 2017)

FCF Cool Flames/ACME JR, 3.5 hrs. Cool Flames/ACME specific, 2 hrs. (June 2017)

Support classes, 1.5 hrs. (MWA & ARIS) (May)** Expect ICBs to be in Russia in July/August 2016 – if not, Sept at JSC.

I53 (52S) / Skvortsov and Vagner

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Proposed training for I54Joint Research training planned: (hours below do not include interpretation) Payload training plan will have the below red text placeholders for Ryz until assignments &/or ICB are completed. GCTC concurrence is needed in August, to support training start in Nov 2016.

Payload Rack classes, 4.5 hrs.(November 2016) EXPRESS Rack, 1 hr. HRF Rack, .25 hr. HRF Refrigerated Centrifuge, .5 hr. HRF Ultrasound 2, .25 hr. MELFI, .75 hr. MSG, 1 hr. WORF, .75 hr.

Rodent Research (Operator) – 21.25 hrs. Consent Briefing, .5 hrs. * Care Briefing, .5 hrs. (Nov 2016)

Generic Rodent Skills, 4 hrs. (Nov 2016)

Rodent Skills 1, 3 hrs. (Feb 2017)

Rodent Skills 3, 3 hrs. (June 2017)

Rodent Skills 4, 3 hrs. (June 2017)

Rodent JR Increment Skills, 3 hrs. (Aug 2017)

Rodent Habitat Animal Transfer, 1.25 hrs. (Aug)

Rodent Habitat Fam for JR, 2 hrs. (Aug 2017)

Support classes: Cold Transfer Skills, 1.0 hrs. (Aug 2017)

FCF Cool Flames/ACME JR, 3.5 hrs. Cool Flames/ACME specific, 2 hrs. (June 2017)

Support classes, 1.5 hrs. (MWA & ARIS) (Feb)* Expect ICBs to be in Russia in July/August 2016 – if not, Nov at JSC.

I54 (53S) / Ryazanskiy

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Backup

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RR-5 Tasks Transfer animals from 2 Transporters to 4 Habitats Initial MSG Set up for the mission duration Animal Transfer from Habitats to MSG (Multiple times) Cleaning of the Access Unit after activity Gather and organize operational support hardware in MSG for Operations Transfer animals from 2 Habitats to 1 Transporter (if Live Animal Return) Perform Bone Densitometry Insert science samples into MELFI Final MSG Clean up and Stow, post mission End of mission inventory check Habitat Preparation & Insert into Express Locker Bag and Stow Transporter Change out of food bars in Habitat Refresh Water Box checks Bag and Stow Habitat Perform Injections and Recovery in MSG Perform Euthanasia (Cardiac Puncture) in MSG

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Russian Rodent Research Mission Assumptions

All rodent on orbit operations will be done by cosmonauts. Animals up/down on the same flight (~30 days) No dissections Euthanize and freeze Bone densitometry and anything requiring anesthesia recovery

is TBD Other ops on-orbit (such as injections) – science objectives

and content are not fully defined and are still being discussed No new Experiment Unique Equipment or on-orbit operations Crew time target 50 – 100 hrs (depending on final science

objectives)Disclaimer: Tasks and science content of the mission is still being determined. The above is assumed but not confirmed. Long term goal is to have Russian crew only missions as a standard once per year. If dissections and other TBD tasks are added to mission tasks, the training time could increase by 8 hours or more.

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Other Joint Research Cool Flames & ACME (4.5 Hrs.) 3.5 Hrs. w/o Interpretation

2 Hrs. Cool Flames and/or ACME specific 1.5 Hrs. system prerequisites 1.0 Hrs. (30% for interpretation)

Fluid Shifts – (18.5 Hrs.)/14 Hrs. w/o Interpretation (completed with Increment 50 crewmembers) Hours do not include BDC 11.75 Hrs. Fluid Shifts payload training 2.25 Hrs. Med Ops prerequisites 4.5 Hrs. (30% for interpretation)

Robonaut – currently no ground training SPHERES-ZR – currently no ground training EarthKAM – currently no ground training

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Tools Training & Support Interpreters will be able to support Sims, crew training, and

other activities to prepare for Rodent missions Interpreters will be trained on all Joint Research payloads

so that they have a better understanding of concepts Interpreters will support on orbit operations All cosmonauts will receive payload rack training beginning

with I53/54 crews. (Details in next slide) Procedures for training and on orbit use are translated Crew training will be conducted over several US trips in

order to build required skills Time for interpretation will be added to all classes Cosmonauts will participate in RO Sims where extra tools

training will be provided – refresh and practice using IPV/PODF, OPTIMUS Viewer, Stowage Notes, and calls to POIC in Huntsville. (Lesson learned)

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Payload Rack Training Agreement in place to train all cosmonauts on payload racks as

follows – beginning with I53/54 cosmonauts: MELFI (.75 Hr.) EXPRESS RACK (1 Hr.) MSG (1 Hr.) HRF RACK (.25 Hr.) HRF Ultrasound 2 (.25 Hr.) HRF Refrigerated Centrifuge (.5 Hr) WORF (.75 Hr.) 30% interpretation = ~1.25

Total for above racks = 5.75 Hrs.

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Typical Rodent Research Flow for USOS, page 1

Pre-assignment Generic Rodent training (includes consent briefings) 40 hours (one week) optimally 16 hours (2 days) minimally – when a crewmember is

identified too late to get the total week Cosmonauts are planned for 4 hours

Payload Facilities – Assigned Flow MELFI Fam – .5 Hr. MSG Fam – .75 Hr. HRF Rack – .25 Hr. HRF Refrigerated Centrifuge – .25 Hr Cold transfer Skills – 1 Hr.

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Typical Rodent Research Flow for USOS, page 2

Skills – Assigned Flow General Skills

Rodent Skills 1 – 3 Hrs. Rodent Skills 2 – 3 Hrs. Rodent Skills 3 – 3 Hrs. Rodent Skills 4 – 4 Hrs. Rodent Habitat & Animal Transfer – 1.25 Hrs.

Increment Specific Skills Increment Specific Skills – 4 Hrs. Increment JR Specific Skills – 3 Hrs.

Totals Pre-assignment: 40 Hours Increment Specific: 24 Hours

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Rodent Research Lesson Objectives, p. 1 Skills 1 Objectives (on bench top)

1. Animal handling/scruffing 2. Subcutaneous (SubQ) injection 3. Intraperitoneal (IP) injection, verify no toe pinch reflex4. Cardiac puncture (open-chest and closed-chest methods); 0.5 mL blood minimum5. Cervical dislocation6. Carcass preparation

Skills 2 Objectives (not required for Increment 51-54 cosmonauts, due to heavy dissection objectives of the class)

1. Animal handling/scruffing2. Subcutaneous (SubQ) injection refresher/practice3. Intraperitoneal (IP) injection refresher/practice; verify no toe pinch reflex4. Cardiac puncture (open-chest and closed-chest) refresher/practice; 0.5 mL minimum5. Cervical dislocation refresher/practice6. Removal of spleen7. Removal of liver8. Removal of bilateral hind limbs9. Removal of bilateral eyes10. Removal of brain11. Carcass preparation

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Rodent Research Lesson Objectives, p. 2 Skills 3 Objectives (Same as Skills 1, but inside MSG simulator. Skip Grip Strength for cosmonauts)

1. Animal handling/scruffing2. Grip Strength measurements3. Subcutaneous (SubQ) injection 4. Intraperitoneal (IP) injection; verify no toe pinch reflex5. Cardiac puncture (open-chest and closed-chest methods); 0.5 mL blood minimum6. Cervical dislocation7. Carcass preparation

Skills 4 Objectives (Inside MSG simulator; eliminate dissection skills for cosmonauts. Reduced time from 4 to 3 hours)

1. Animal handling/scruffing2. Subcutaneous (SubQ) injection refresher/practice3. Intraperitoneal (IP) injection refresher/practice; verify no toe pinch reflex4. Adhesion of animal to Exam Tray and use of the Exam Box for bone densitometry scanning; application

of eye ointment5. Use of the Anesthesia Recovery System (ARS) and recognition of recovery signs6. Cardiac puncture (open-chest and closed-chest) refresher/practice; 0.5 mL minimum7. Dissection and tissue collection practice

a. Spleen b. Liver c. Eyes d. Brain e. Hind limbs f. Tissue preparation/use of Rodent Tissue Box

8. Cervical dislocation9. Carcass preparation

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Rodent Research Lesson Objectives, p. 3 Increment Specific Skills (RR-5/UCLA, inside MSG simulator)

1. Animal handling/scruffing 2. Subcutaneous (SubQ) injection 3. Intraperitoneal (IP) injection 4. Adhesion of animal to Exam Tray and use of the Exam Box for bone densitometry scanning;

application of eye ointment5. Use of the Anesthesia Recovery System (ARS) and recognition of recovery signs6. Cardiac puncture (closed-chest); minimum of 0.5mL per animal7. Cervical dislocation (secondary method of euthanasia)8. Carcass preparation

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Rodent Research Hardware Overview

TRANSPORTER

• Up to 20 mice, up to 12 rats• Powered for ascent• Powered on ISS during Animal Transfer Operations• No visual checks of the animals (no cameras)• Lighting (Visible)• Returns passive for used Transporters, returns powered for live animal return

HABITAT

•10 mice or 3 – 6 rats•No thermal control•Video monitoring (4 cameras)•Lighting (Visible and IR)•In-flight access•Launches and returns passive

ACCESS UNIT

• Attaches to either Transporter or Habitat

• Provides for animal access and transfer of animals

• Remains on orbit in stowage between increments

US equipment operated in the USOS

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Operational Support Hardware Overview A fully set up MSG with Operational Support Hardware

(OSH)

Documents

Joint Research (JR) Training Rodent Research and General · PDF fileJoint Research (JR) Training Rodent Research and General JR ... **ICBs expected to take place in Russia starting